https://scialert.net Research Journal of Environmental Toxicology en-us Science Alert Thu, 11 Jun 2026 18:11:57 +0200 Thu, 11 Jun 2026 18:14:14 +0200 RssPublisher 0.2.0 beta https://scialert.net/images/logo.gif https://scialert.net 41 233 Research Journal of Environmental Toxicology Assessment of the Acute Toxicity of “Oxamax®”, Carbamate Insecticide Based Oxamyl (50 mg/kg) Background and Objective: Carbamate pesticides are recognized for their high acute toxicity with an inhibitory action on acetylcholinesterase activity. This study aims to evaluate the acute toxicity of “Oxamax^®”, a carbamate insecticide, an oxamyl-based formulation, in rats and rabbits. Materials and Methods: Oncins France Strain A (OFA) rats aged 8 to 12 weeks were used for acute oral and respiratory toxicity tests. For skin and eye toxicity tests, rabbits of the New Zealand breed with an average weight of 3 kg were used. The various tests were conducted according to OECD guidelines for chemical testing. Acetylcholinesterase activity was assessed in animals exposed to the respiratory route. Results: Animals treated orally showed clinical signs of toxicity (apathy, drowsiness, convulsions and death) at a dose of 300 mg/kg. With an oral Lethal Dose 50 (LD₅₀) in rats between 50 and 300 mg/kg, Oxamax^® can be classified in category 3 of the Globally Harmonised System of Classification and Labelling of Chemicals (GHS). The primary dermal irritation index (PDII) determined for this carbamate is 3.11. Oxamax^® is classified as moderately irritating to the skin. The maximum mean total score (MMTS) for “Oxamax^®” was 46.3, classifying the product as moderately irritating to the eyes. The rate of inhibition of cholinesterase activity varied from 23.9 to 83.17% for doses ranging from 0.5 to 5 mg/L following exposure for 4 hrs. Conclusion: Like most carbamate pesticides, “Oxamax^®” exerted high acute toxicity by the oral, dermal, ocular and respiratory routes. This molecule must be used in strict compliance with the instructions for use.]]> https://scialert.net/abstract/?doi=rjet.2024.1.7 11 June, 2026