https://scialert.net American Journal of Drug Discovery and Development en-us Science Alert Thu, 11 Jun 2026 18:11:57 +0200 Thu, 11 Jun 2026 18:14:14 +0200 RssPublisher 0.2.0 beta https://scialert.net/images/logo.gif https://scialert.net 41 233 American Journal of Drug Discovery and Development Leptadenia hastata Pers. (Decne) a Promising Source for Natural Compounds in Biomedical Applications Leptadenia hastata (Pers) Decne. of Apocynaceae family is an African plant which is used as nutriment as well as for medical purposes due to its health promoting properties. Traditional healers use L. hastata to treat many diseases as hypertension, sexual impotence, trypanosomosis, acute rhinopharyngitis. In quantitative and qualitative terms, the leaves of L. hastata contain significant quantities of secondary metabolites, as triterpenes, total flavonoids, tanins, which can be important in biomedical research. In vivo studies showed the antifertility effect of L. hastata leaves extracts which can be useful for hormonal therapy replacement. Herein, the ecology, traditional medicinal uses, phytochemistry, toxicity and pharmacology of L. hastata in consideration of its antifertility activity is reviewed. In view of its constituents such as steroidal glycosides, triterpenes and polyoxypregnane derivatives, further investigation on the effect of L. hastata on other hormonal endpoints like hormone dependent cancers appears promising.]]> https://scialert.net/abstract/?doi=ajdd.2018.1.10 11 June, 2026