1. Transbronchial biopsy performed with a cryoprobe demonstrated a significantly higher diagnostic yield compared to conventional forceps biopsy in patients undergoing evaluative bronchoscopy. 2. Cryobiopsy produced larger and higher-quality tissue samples with less crush artifact without increasing rates of major bleeding, respiratory failure, or pneumothorax requiring intervention. Evidence Rating Level: 1 (Excellent) Study Rundown: Transbronchial […]

The post Cryoprobe improves diagnostic yield compared with forceps in bronchoscopic lung biopsy first appeared on 2 Minute Medicine.

 

1. Lymph node sampling with the 3 + 1 rule was not associated with increased postoperative complications after lung cancer resection. Evidence Rating Level: 2 (Good) Non–small cell lung cancer (NSCLC) is the most common type of lung cancer, accounting for about 80-85% of all lung cancers. Surgical removal of the tumor with lymph node sampling (LNS) […]

The post Guideline-based lymph node sampling is not associated with increased postoperative complications in lung cancer first appeared on 2 Minute Medicine.

 

1. Gilead reported positive phase 3 IDEAL data for seladelpar (Livdelzi) in patients with primary biliary cholangitis who had persistent alkaline phosphatase elevation. 2. The findings support a broader treatment goal in primary biliary cholangitis, moving beyond partial biochemical improvement toward normalization of disease markers. Gilead has reported positive phase 3 IDEAL data for seladelpar […]

The post Seladelpar (Livdelzi) raises the bar for primary biliary cholangitis treatment first appeared on 2 Minute Medicine.

 

1. Prediagnostic statin use was not associated with higher survival among patients with early breast cancer. 2. Postdiagnostic statin use was associated with lower all-cause and breast cancer–specific mortality among early breast cancer patients with hormone receptor–positive intrinsic subtypes. Evidence Rating Level: 2 (Good) Although statins are commonly prescribed drugs to reduce the risk of […]

The post Statin use after but not before breast cancer diagnosis is associated with improved mortality in hormone receptor-positive early breast cancer first appeared on 2 Minute Medicine.

 

1. The European Commission has authorized expanded venetoclax (Venclyxto) combinations for previously untreated chronic lymphocytic leukemia. 2. The approval reinforces the continued movement toward fixed-duration, chemotherapy-free regimens in chronic lymphocytic leukemia care. AbbVie has received European Commission authorization for expanded use of venetoclax (Venclyxto) in previously untreated chronic lymphocytic leukemia. The updated indication includes venetoclax […]

The post Venetoclax (Venclyxto) expands treatment options as chronic lymphocytic leukemia care moves further from chemotherapy first appeared on 2 Minute Medicine.

 

Food Coloring Additives and Incidence of Type 2 Diabetes in the NutriNet-Santé Prospective Cohort 1. Several widely consumed natural and synthetic food coloring additives were associated with higher type 2 diabetes incidence. Evidence Rating Level: 2 (Good) Ultraprocessed foods (UPFs) have been linked to increased type 2 diabetes incidence independent of energy intake and adiposity. […]

The post 2 Minute Medicine Rewind June 8, 2026 first appeared on 2 Minute Medicine.

 

1. The FDA has expanded the label for guselkumab (Tremfya) to include evidence that it can inhibit progression of structural joint damage in adults with active psoriatic arthritis. 2. Phase 3b APEX data showed stronger clinical responses and less radiographic progression with guselkumab compared with placebo. Johnson & Johnson has secured an important FDA label […]

The post Guselkumab (Tremfya) strengthens its case for protecting joints in psoriatic arthritis first appeared on 2 Minute Medicine.

 

1. Pfizer has committed $650 million upfront in a collaboration with Innovent Biologics that could ultimately reach $10.5 billion in total value. 2. The agreement underscores the growing importance of China-based biotechnology companies as sources of globally competitive oncology innovation. Pfizer is making one of the largest oncology licensing bets seen this year through a […]

The post Why Pfizer Is Looking East for Its Next Generation of Cancer Drugs first appeared on 2 Minute Medicine.

 

Pfizer and Innovent deepen the China biotech licensing wave Pfizer is making another large oncology bet, this time through a broad collaboration with Innovent Biologics that could be worth up to $10.5 billion. The agreement includes $650 million upfront and covers 12 early stage cancer programs, including antibody drug conjugates and multispecific antibodies. That mix […]

The post 2MM: Pharma Roundup – Pfizer’s $10.5B Innovent oncology partnership, Guselkumab (Tremfya) gains a broader psoriatic arthritis label, Venetoclax (Venclyxto) expands first-line CLL options, and Seladelpar (Livdelzi) advances in primary biliary cholangitis first appeared on 2 Minute Medicine.

 

1. The Canadian Syncope Risk Score (CSRS) and FAINT score are effective at identifying which adult patients presenting to the emergency department (ED) are at low risk for short-term adverse outcomes. Evidence Rating Level: 2 (Good) Syncope and presyncope account for 2-3% of all ED visits, with approximately 10% of these patients having serious underlying […]

The post Two scores for risk stratification of adults presenting with syncope may be effective at identifying those with low risk first appeared on 2 Minute Medicine.