Alzforum - Papers of the Week: 8-14 May 2026

Expression of concern: "Propofol improved neurobehavioral outcome of cerebral ischemia-reperfusion rats by regulating Bcl-2 and Bax expression" [Brain Res. 1410 (2011) 24-32].

Brain Res. 2026 Aug 15;1885:150342. Epub 2026 Apr 25
Authors: Xi HJ, Zhang TH, Tao T, Song CY, Lu SJ, Cui, Yue ZY
PubMed: 42106167
Submit Comment

Mapping the conformational variability in mutants of the amyloid precursor protein intracellular domain.

J Mol Biol. 2026 Jul 15;438(14):169806. Epub 2026 Apr 11
Authors: Mandal N, Skepö M
PubMed: 41967599
Submit Comment

NMR characterization of the structure and interaction of an RNA aptamer targeting α-synuclein.

Biochem Biophys Res Commun. 2026 Jul 9;821:153874. Epub 2026 May 4
Authors: Li X, Yamaoki Y, Nagata T, Murakami K, Katahira M
PubMed: 42114215
Submit Comment

Advanced diffusion MRI tract signatures in Alzheimer's disease, dementia with Lewy bodies, and the FTD/PPA spectrum.

Neuroimage. 2026 Jul 1;334:121984. Epub 2026 May 8
Authors: Tian Y, Whitwell JL
PubMed: 42107617
Submit Comment

LABMA: Latent-bottleneck attention-based multimodal architecture for integration of transcriptomics, proteomics, and MRI in neurodegeneration.

Comput Biol Med. 2026 Jul 1;210:111740. Epub 2026 May 12
Authors: Niwarthana A, Rajapakse JC
PubMed: 42114436
Submit Comment

Integrative systems pharmacology and experimental Assessment of hyaluronic Acid-Curcumin conjugate in an Alzheimer's disease model.

Comput Biol Med. 2026 Jul 1;210:111744. Epub 2026 May 12
Authors: Gayathri SV, Manjunatha PM, Pai P, Muzzammil Bahawuddeen Khalwathi M, Jana P, Akhila AV, Priya A, Prerna, Satvik, Marwein AS, Nchimbi AH, Atem AE, Sharma UR, Hari Babu T
PubMed: 42114435
Submit Comment

The Role of Clinical, Plasma, and Imaging Biomarkers in Assessing Future Dementia Risk in Individuals With Subjective Cognitive Decline.

Neurology. 2026 Jun 9;106(11):e214983. Epub 2026 May 14
Authors: Rivera Sánchez M, Mastenbroek SE, Janelidze S, Tideman P, Mattsson-Carlgren N, Van Westen D, Stomrud E, Hansson O, Palmqvist S, Ossenkoppele R
PubMed: 42133909
Submit Comment

Asymptomatic Versus Symptomatic Alzheimer's Disease Neuropathology: A Systematic Review of Differences Reported in Post-Mortem Studies.

Neuropathol Appl Neurobiol. 2026 Jun;52(3):e70077.
Authors: Barros TG, Grossi LB, da Silva Campos ML, Cardoso IB, Teixeira AL, de Miranda AS, de Brito Toscano EC
PubMed: 42103686
Submit Comment

Bridging the Funding Gap in Drug Development for Amyotrophic Lateral Sclerosis.

Neurol Clin Pract. 2026 Jun;16(3):e200623. Epub 2026 May 4
Authors: Bareamichael PI, Babu S, Hoang T, Socal MP
PubMed: 42114078
Submit Comment

Evaluating the Duke Iterative Cognitive Examination Against the Montreal Cognitive Assessment: Validity and Clinical Utility.

Neurol Clin Pract. 2026 Jun;16(3):e200617. Epub 2026 Apr 23
Authors: Park C, Farrer TJ, Stuart JZ, Johnson KG, Lutz MW, O'Brien RJ, Quiroga Del Rio CE, Chin PE, Koltai DC
PubMed: 42114070
Submit Comment

Clinical Meaningfulness of Donanemab in Early Symptomatic Alzheimer Disease: Data From the Randomized Phase 3 TRAILBLAZER-ALZ 2 Trial.

Neurol Clin Pract. 2026 Jun;16(3):e200621. Epub 2026 May 13
Authors: Atri A, Apostolova LG, Iwata A, Wessels AM, Atkins A, Lu M, Ye W, Ryan S, Doty EG
PubMed: 42128444
Submit Comment

New evidence on the clinical, genetic, and biochemical bases of GBA1-Parkinson's disease: prospects for treatment.

Lancet Neurol. 2026 Jun;25(6):602-614.
Authors: Menozzi E, Toffoli M, Deleidi M, Di Monte DA, Blandini F, Krainc D, Sidransky E, Schapira AH
PubMed: 42127935
Submit Comment

Identification of genetic modifiers of autosomal dominant Alzheimer's disease: a genome-wide association study.

Lancet Neurol. 2026 Jun;25(6):581-590.
Authors: Patel M, Feng W, Mckay NS, Millar PR, Liu M, Yang C, Cetin A, Johnson M, Budde J, Western D, Marsh TW, Saliu IO, Gordon BA, Guerra JJ, Morris JC, Bateman RJ, McDade E, Holtzman DM, Ryan NS, Benzinger TL, Renton AE, Goate AM, Ibanez L, Sung YJ, Zhao G, Cruchaga C, Pottier C, Dominantly Inherited Alzheimer Network
PubMed: 42127933
Submit Comment

Safety, tolerability, and efficacy of acetazolamide in idiopathic normal pressure hydrocephalus (DRAIN) in Sweden: a randomised, double-blind, placebo-controlled, phase 2 trial.

Lancet Neurol. 2026 Jun;25(6):550-559.
Authors: Virhammar J, Fasth O, Ekblom M, Ekman O, Holmstrand N, Fällmar D, Nyholm D
PubMed: 42127932
Submit Comment

Genetic modifiers in autosomal dominant Alzheimer's disease.

Lancet Neurol. 2026 Jun;25(6):537-538.
Authors: Kosik KS
PubMed: 42127918
Submit Comment

FTLD-TDP-43 With Motor Neuron Disease Pathology in an Autopsied Patient With Spastic Paraplegia-30B Harbouring a Homozygous KIF1A Variant.

Neuropathol Appl Neurobiol. 2026 Jun;52(3):e70079.
Authors: Saito R, Hasegawa A, Takahashi T, Koike R, Hara N, Gabdulkhaev R, Koh K, Kawakami A, Takiyama Y, Ikeuchi T, Kakita A
PubMed: 42130092
Submit Comment

Neuronal PRRT3 coordinates amyloidogenic processing and Tau phosphorylation via distinct Ras-ERK-AP-1 and CaMKII/PP2A pathways.

Acta Biochim Biophys Sin (Shanghai). 2026 May 25; Epub 2026 May 25
Authors: Chen F, Zhang H, Huang Y, Zhu J, Cui F, Liang S, Li Y, Wang Y, Xie X, Liu R
PubMed: 42130394
Submit Comment

Using iPSC models to examine neuron-glia interactions in neurodegenerative diseases.

Biosci Rep. 2026 May 20;46(5)
Authors: Lopez DM, Keavey LK, Bowles KR
PubMed: 42101666
Submit Comment

Integrated clinical and computational data-based repurposing of econazole as a novel autophagic activator in ULK1-related Parkinson disease.

Autophagy. 2026 May 17;:1-21. Epub 2026 May 17
Authors: Zhang J, Jin W, Fu Y, Zhen Y, Chen Y, Liu W, Huang W, Wang Z, Zhu HP, Yang QQ, Zhan G, Zhao Q, Peng C, Zhang L, Han B, Liu B
PubMed: 42112758
Submit Comment

Advances in modeling memory decline: A critical overview of current animal and human paradigms.

Ageing Res Rev. 2026 May 15;119:103172. Epub 2026 May 15
Authors: Peng Y, Li Y, Ma L, Wu T, Chen G
PubMed: 42114723
Submit Comment

Exposure to fibrillar proteins leads to widespread infiltration but only mild tau pathology in cortical organoids.

iScience. 2026 May 15;29(5):115819. Epub 2026 Apr 20
Authors: Dakhel A, Mothes T, Eltom K, Michno WP, Erlandsson A
PubMed: 42111182
Submit Comment

The intrinsic disorder challenge for AlphaFold: A case study of G3BP1 and pathogenic peptide.

iScience. 2026 May 15;29(5):115737. Epub 2026 Apr 15
Authors: Li Y, Yao Z, Song Z, Yang P, Huang J, Lei K, Xu Y
PubMed: 42111176
Submit Comment

Allele-specific splicing modulates protein isoforms and Alzheimer's risk.

Genome Res. 2026 May 15; Epub 2026 May 15
Authors: King AJ, Amoah K, Zhang L, Bahn JH, Barney RM, Quinones-Valdez G, Xiao X
PubMed: 42134986
Submit Comment

A human Staufen1 BAC transgenic mouse exhibits abnormal autophagy and neurodegeneration across the central nervous system.

Cell Death Dis. 2026 May 14; Epub 2026 May 14
Authors: Pulst SM, Paul S, Nguyen H, Dansithong W, Figueroa KP, Gandelman M, Bonini NM, Scoles DR
PubMed: 42129145
Submit Comment

Psychiatric and behavioral disorders in Parkinson's disease: co-pathogenic mechanisms of tau, Aβ, and α-synuclein proteins (narrative review).

Rev Neurosci. 2026 May 14; Epub 2026 May 14
Authors: Chai JY, Zhang Y, Zhang ZQ, Ma DR, Cao YH, Zhu SR, Ma YZ, Luo LL, Zhan YL, Fan ZY, Lan R
PubMed: 42125890
Submit Comment

Cellular state heterogeneity underlying sex differences in Alzheimer's disease based on single-cell transcriptome.

Alzheimers Res Ther. 2026 May 14; Epub 2026 May 14
Authors: Wu Z, Tan Q, Xue F, Jiang Z, Zhao H, Zhang Y, Liu Y, Zhang Y, Ding D, Chen H, Xu Y, Li F, Zhang C
PubMed: 42135783
Submit Comment

Maintenance and disruption of the physiological dimer structure of TDP-43 in amyotrophic lateral sclerosis and frontotemporal lobar degeneration.

BMC Med. 2026 May 14; Epub 2026 May 14
Authors: Tamaki Y, Kaneko S, Urushitani M
PubMed: 42135750
Submit Comment

Role of endolysosome iron in amyloid-β protein-induced increases in reactive oxygen species, mitochondrial depolarization, and cytotoxicity.

J Alzheimers Dis. 2026 May 14;:13872877261449714. Epub 2026 May 14
Authors: Quansah DN, Halcrow PW, Kumar N, Liang B, Geiger JD
PubMed: 42135618
Submit Comment

The bidirectional association of epilepsy with Alzheimer's disease and other neurodegenerative dementias: A longitudinal observational study on the UK Biobank.

J Alzheimers Dis. 2026 May 14;:13872877261450962. Epub 2026 May 14
Authors: Fratto E, Buonocore J, Fortunato F, Sammarra I, Calomino C, Vescio B, Quattrone A, Gambardella A, Quattrone A
PubMed: 42135610
Submit Comment

Reduced ULK1 links impaired autophagy and mitophagy to Alzheimer's disease pathology.

Nat Aging. 2026 May 14; Epub 2026 May 14
Authors: Pan JP, Wang PJ, Zhang J, Knapskog AB, Watne LO, Wang HL, Lagartos-Donate MJ, Lautrup S, Mao LP, Wang Q, Ling ZP, Zhang SQ, Schmauck-Medina T, Ai R, Edwin TH, Zhang T, Saltvedt I, Eldholm RS, Smith A, Veverová K, Caponio D, Kobro-Flatmoen A, Pang H, Wang Z, Wang H, Gao LJ, Halaas NB, Wong G, Vyhnalek M, Luo OJ, McEwan WA, Storm-Mathisen J, Gan L, Hu Z, Zetterberg H, Witter MP, Aarsland D, Selbæk G, Chen G, Fang EF
PubMed: 42135576
Submit Comment

Brain Amyloid Deposition Is Negatively Associated with Cardiac Amyloid Retention in Apo E4 Carriers: A Pilot Study.

Mol Imaging Biol. 2026 May 14; Epub 2026 May 14
Authors: Pak K, Kim J, Kim K, Kim K, Kim YJ, Lee H, Suh H, Moon E, Lee BD, Park JM, Choi JH, Lee YM
PubMed: 42135537
Submit Comment

Integrated single-cell and spatial transcriptomic profiling in ALS uncovers peripheral-to-central immune infiltration and reprogramming.

Nat Neurosci. 2026 May 14; Epub 2026 May 14
Authors: Zhang Z, van Olst L, Alessandrini F, Wright M, Edwards AJ, Boles J, Nalbandian A, Forsyth AV, Shepard N, Watson T, Kaspi E, Mittal A, Kuruvilla J, Piehl N, Ramakrishnan A, Appel S, Kiskinis E, Gate D
PubMed: 42135512
Submit Comment

Multi-locus genetic dosage shapes cognitive disease progression in Parkinson's patients: 15-year meta-analysis of 24 cohorts.

NPJ Parkinsons Dis. 2026 May 14; Epub 2026 May 14
Authors: Kang X, Lin Z, Calikusu FZ, Miller LA, Soriano S, Locascio JJ, Corvol JC, Maple-Grødem J, Fan Y, Mead K, Campbell MC, Elbaz A, Lesage S, Brice A, Hung AY, Schwarzschild MA, Hayes MT, Wills AM, Herrington TM, Liu G, Ravina B, Taba P, Kõks S, Simuni T, Forsgren L, Counsell C, Macleod AD, Beach TG, Alves G, Tysnes OB, Perlmutter JS, Heutink P, Kasten M, Mollenhauer B, Trenkwalder C, Klein C, Hepp DH, Backstrom D, Svenningsson P, Hu MT, Williams-Gray CH, Barker RA, International Genetics of Parkinson Disease Progression (IGPP) Consortium, Scherzer CR
PubMed: 42135313
Submit Comment

1-deoxysphinganine promoted microglial glycolytic reprogramming and neuroinflammation in alzheimer's disease.

Transl Psychiatry. 2026 May 14; Epub 2026 May 14
Authors: Ye T, Lv X, Fang Z, Li Q, Chen F, Dong Y, Xiang K, Yang Y, Dai C, Do QL, Sun J, Su KP, Liu J
PubMed: 42135307
Submit Comment

Single-nucleus epigenomic dysregulation unmasks genetic risk-associated neurodegenerative glia states.

Nat Commun. 2026 May 14; Epub 2026 May 14
Authors: Han X, Rosenberg GM, Kisling VM, Zhang T, Lee CY, Ravi A, Melnik M, Bilousova T, Spina S, Nana AL, Grinberg LT, Seeley WW, Gylys KH, Huckins LM, Raj T, Brennand KJ, Rexach JE
PubMed: 42135303
Submit Comment

Epigenetic noise in the aging brain: tuning neuronal vulnerability to neurodegeneration.

Trends Neurosci. 2026 May 14; Epub 2026 May 14
Authors: Yin X, Zhang H, Zhang R, Xue J, Hou Y
PubMed: 42135109
Submit Comment

Epigenetic aging and blood based neurodegeneration markers in LASI-DAD.

J Prev Alzheimers Dis. 2026 May 14;13(7):100595. Epub 2026 May 14
Authors: Kim JK, Arpawong TE, Thyagarajan B, Smith JA, Vivek S, Ratliff S, Dey S, Lee J, Crimmins EM
PubMed: 42134227
Submit Comment

Glucagon-Like Peptide-1 Receptor Agonists Inhibit the Initiation of Toxic Amyloid-β42 Aggregation.

J Am Chem Soc. 2026 May 14; Epub 2026 May 14
Authors: Fallot LB, Anderson CA, Pinc JR, Stevenson A, Schleck MC, Hawryschuk E, Li OZ, Palchak JC, Toole JR, Kubiak Ii RW, Dear AJ, Michaels TC, Limbocker R
PubMed: 42133988
Submit Comment

Dementia studies come to grips with overlapping diseases.

Science. 2026 May 14;392(6799):675-676. Epub 2026 May 14
Authors: Smith JE
PubMed: 42133777
Submit Comment

Exploring Lymphovenous Anastomosis for Alzheimer's Disease: Addressing Brain Lymphatic Dysfunction, Feasibility, and Outcome Metrics.

Plast Reconstr Surg. 2026 May 14; Epub 2026 May 14
Authors: Brown S, Klimitz FJ, Kipnis J, Benveniste H, Ringstad G, Eide PK, Azizi S, Mecca A, Haykal S, Pomahac B
PubMed: 42133667
Submit Comment

Regulation between LRRK2 and PP2A signaling in cellular models of Parkinsons disease.

Biochem J. 2026 May 14; Epub 2026 May 14
Authors: Athanasopoulos PS, Memou A, Ho FY, Soliman A, Pots H, Papadopoulou V, von Zweydorf F, Sriraman S, Thouin AM, Vandewynckel L, Sibran W, Chartier-Harlin MC, Nichols RJ, Greggio E, Taymans JM, Gloeckner CJ, Rideout HJ, Kortholt A
PubMed: 42133347
Submit Comment

Alterations of homotopic functional connectivity and correlates with core neuropsychological impairments in mild cognitive impairment: a resting-state fMRI study.

Brain Imaging Behav. 2026 May 14;20(3)
Authors: Guo Y, Gao Y, Liu Y, Nie X, Xiong Q, Ren Z
PubMed: 42133147
Submit Comment

Purinergic modulation in Parkinson's disease: the dual role of istradefylline in motor and cognitive outcomes.

Purinergic Signal. 2026 May 14;22(3)
Authors: Rejili M, Al-Kuraishy HM, Al-Gareeb AI, Albuhadily AK, Jabir MS, Shokr MM, Batiha GE
PubMed: 42133141
Submit Comment

From epigenetic scripts to kinase signals: linking DOT1L and RIPK1 in the neurobiology of degeneration.

Mol Biol Rep. 2026 May 14;53(1)
Authors: Kalra P, Grewal AK, Khan H, Chaturvedi D, Singh TG
PubMed: 42133133
Submit Comment

Detecting the seeds of Parkinson's disease: the evolution of α‑synuclein seed amplification assay as a clinical biomarker.

J Neural Transm (Vienna). 2026 May 14; Epub 2026 May 14
Authors: Bautista JM, Quanico CJ, Cataniag P, Guillermo JG, Hattori N
PubMed: 42133018
Submit Comment

The correlates of hyperechogenicity of the substantia nigra in subjects at risk of dementia with Lewy bodies.

J Neural Transm (Vienna). 2026 May 14; Epub 2026 May 14
Authors: Zelníčková K, Ondráček D, Mikulec M, Mekyska J, Farkaš J, Lamoš M, Rektorová I
PubMed: 42133012
Submit Comment

Visual memory in Parkinson's Disease: a non-graphomotor approach to assessment.

J Neural Transm (Vienna). 2026 May 14; Epub 2026 May 14
Authors: Bhardwaj M, Prasad S, Kumar KJ, Nagaraj T, Bhat SG, Mailankody P, Mahale RR, Holla VV, Kamble N, Yadav R, Pal PK
PubMed: 42133010
Submit Comment

From MRI to 3D printing: a tangible neuroeducational tool for visualizing hippocampal morphology and Alzheimer's disease progression.

J Neural Transm (Vienna). 2026 May 14; Epub 2026 May 14
Authors: Sodaei F, Vafaee MS, Michel TM, Rad HS, Noroozian M
PubMed: 42133009
Submit Comment

Oleic and omega-3 fatty acids buffer neuroinflammation in a scopolamine model with Alzheimer's-like features via target-level interactions.

Food Funct. 2026 May 14; Epub 2026 May 14
Authors: Albertuni M, Torrecillas-Lopez M, Gonzalez-de la Rosa T, Barrera-Chamorro L, Marquez-Paradas E, Del Rio-Vazquez JL, Navarro-Hortal MD, Claro-Cala CM, Montserrat-de la Paz S
PubMed: 42132882
Submit Comment

α-synuclein PET imaging: early human evidence and the path toward clinical proof-of-concept.

Expert Rev Mol Diagn. 2026 May 14; Epub 2026 May 14
Authors: Filippi L, Urbano N
PubMed: 42132158
Submit Comment

Photocontrollable Electrochemical Molecular Probe for the Detection of Cu2+ in Brain Dialysates of Alzheimer's Disease Mice.

ACS Sens. 2026 May 14; Epub 2026 May 14
Authors: Dong H, Zhao L, Guo G, Chang A, Cheng M, Qian Y, Hu L, Zhou J, Ye Y, Zhou Y, Ma Y, Li Z, Xu M
PubMed: 42132079
Submit Comment

Identification and Enrollment of Individuals Prior to Parkinson's Disease Diagnosis: Biomarker-Driven Adaptive Eligibility and Enrollment into the Parkinson's Progression Markers Initiative.

Ann Neurol. 2026 May 14; Epub 2026 May 14
Authors: Brown EG, Chahine LM, Dobkin RD, Simuni T, Foroud T, Heathers LE, Tropea TF, Stanley CE Jr, McMahon BA, Brüggemann N, Klein C, Postuma RB, Johnson NS, Gochanour C, Caspell-Garcia C, Kurth R, Brumm MC, Coffey CS, Marek K, Tanner CM, Parkinson's Progression Markers Initiative
PubMed: 42132059
Submit Comment

Gut Microbiota Dysbiosis Drives Early Alzheimer's Pathogenesis via Microglial TREM2/SYK/NF-κB Signaling Axis.

ACS Chem Neurosci. 2026 May 14; Epub 2026 May 14
Authors: Tian M, Wang D, Zhang C, Fan J, Li W, Liu X, Shi J
PubMed: 42130461
Submit Comment

Molecular Insights into Parkinson's Disease Progression: A Multi-omics Analysis of the Substantia Nigra Pars Compacta across Braak Stages.

Exp Neurobiol. 2026 May 14; Epub 2026 May 14
Authors: Kim S, Choi JG, Kim SW, Son M, Kim D, Nam SJ, Kim SJ, Kim S, Korea Brain Bank Network
PubMed: 42130054
Submit Comment

Emotion recognition deficits in Alzheimer's disease: A meta-analysis.

Neurosci Biobehav Rev. 2026 May 13;187:106745. Epub 2026 May 13
Authors: Zamora A, Balboa-Bandeira Y, Peña J, Ojeda N
PubMed: 42114728
Submit Comment

Investigating how changes in the levels of kinesins impact neuronal health in Drosophila and human iPSC-derived neurons AD model.

Open Biol. 2026 May 13;16(5)
Authors: Francis D, Paonessa F, Hewitt VL, Southall M, Peset I, Whitworth AJ, Livesey FJ, Fabre CC, Palacios IM
PubMed: 42120060
Submit Comment

Spatiotemporal brain transcriptomics reveal risk gene hot-spots in major neuropsychiatric disorders.

Commun Biol. 2026 May 13;9(1)
Authors: Liu W, Shimogori T
PubMed: 42129508
Submit Comment

Cytokine gene polymorphisms and serum cytokine levels identify a neuroinflammatory nexus in Alzheimer's disease.

Sci Rep. 2026 May 13; Epub 2026 May 13
Authors: Wang Z, Xia X
PubMed: 42129267
Submit Comment

Functional system-specific brain aging across the Alzheimer's disease continuum.

Transl Psychiatry. 2026 May 13; Epub 2026 May 13
Authors: Huo Y, Huang W, Liu Z, Chen H, Bai T, Wang Y, Wang K, Zhang D, Cheng J, Sun Y, Ma G, Zhao C, Zhang Z, Shu N
PubMed: 42129136
Submit Comment

Correction: EEG-based classification of alzheimer's disease and frontotemporal dementia using functional connectivity.

Sci Rep. 2026 May 13;16(1)
Authors: Mlinarič T, Van Den Kerchove A, Barinaga ZI, Van Hulle MM
PubMed: 42128892
Submit Comment

Interaction of diet and physical activity on dementia risk: the Rotterdam study.

J Prev Alzheimers Dis. 2026 May 13;13(7):100594. Epub 2026 May 13
Authors: Sambou ML, Ikram MA, Ikram MK, Labrecque JA, Wolters FJ
PubMed: 42128461
Submit Comment

Modeling Alzheimer's disease with human multi-omics profiles: Promise to personalized medicine.

Curr Opin Neurobiol. 2026 May 13;99:103210. Epub 2026 May 13
Authors: Ip NY
PubMed: 42127889
Submit Comment

Relationship between intracranial pressure waveform parameters and quantitative biomarkers of Alzheimer's disease from brain tissue and cerebrospinal fluid in idiopathic normal pressure hydrocephalus.

J Clin Neurosci. 2026 May 13;151:112082. Epub 2026 May 13
Authors: Jaeger M, McMahon S, Murambi RT, Chakravorty A, Ecroyd HW
PubMed: 42127521
Submit Comment

A phase 1, safety, tolerability, and pharmacokinetics study of bisnorcymserine, a highly selective inhibitor of butyrylcholinesterase.

Neurotherapeutics. 2026 May 13;23(3):e00918. Epub 2026 May 13
Authors: Tzieras I, Manolopoulos A, Tweedie D, Luo W, Maccecchini M, Egan JM, Greig NH, Kapogiannis D
PubMed: 42127455
Submit Comment

MusicAlzheimer: AI-Powered, Culturally Tailored Digital Music Therapy Prototype for Alzheimer Disease Care.

JMIR Form Res. 2026 May 13;10:e89535.
Authors: Yang S, Zhang DY, Zhang M, Yang H, Ma Y
PubMed: 42127381
Submit Comment

Conjugation of Dietary Carnosine to Phe-Leu Dipeptide Affords a Potent Inhibitor of Multifaceted Aβ-Induced Neurotoxicity.

Bioconjug Chem. 2026 May 13; Epub 2026 May 13
Authors: Singh K, Priyadarshi N, Goyal B, Singhal NK, Goyal D
PubMed: 42127283
Submit Comment

Cognitive and Neuroanatomical Effects of Fatty Acid Amide Hydrolase Polymorphism rs324420 in Aging and Alzheimer Disease.

Alzheimer Dis Assoc Disord. 2026 May 13; Epub 2026 May 13
Authors: Mori-Fegan DK, Wong YY, Noor S, Wu CY, Ryoo S, Mielnik C, Ross RA, Swardfager W
PubMed: 42127232
Submit Comment

Early Detection of Alzheimer's Disease and Related Dementias From Spontaneous Speech Using Foundation Speech and Language Models: Comparative Evaluation.

JMIR Form Res. 2026 May 13;10:e79411.
Authors: Li J, Mao L, Mao X, Wang H, Wang Z, Ni XS
PubMed: 42126910
Submit Comment

Subjective Cognitive Complaints and Hearing Loss in Older Adults-A Cross-Sectional Study on the Possible Association.

Scand J Psychol. 2026 May 13; Epub 2026 May 13
Authors: Vogel A, Hendel RK, Jørgensen M, Kressner AA
PubMed: 42126868
Submit Comment

Semaglutide ameliorates neuroinflammation and cognitive impairment in APP/PS1 mice.

Mol Cell Biochem. 2026 May 13; Epub 2026 May 13
Authors: Yuan Y, Zhang J, Zhang Z, Zhai Y, Cheng XJ, Xue L, Zhao F, Cao L, Wang H
PubMed: 42126676
Submit Comment

When bad turns good: a systematic review on cholesterol and LDL in longitudinal patient cohorts with Parkinson's disease.

Neurol Sci. 2026 May 13;47(6)
Authors: Lumi R, Tartakovskaja J, Ye L, Abraham B, Niesmann C, Greten S, Wegner F, Klietz M
PubMed: 42126660
Submit Comment

Engineered Exosomes: Innovative Strategies for Precision Drug Delivery in Parkinson's Disease.

Mol Neurobiol. 2026 May 13;63(1)
Authors: Yuan X, Wang C, Yan J, Wang J, Li F, You Y, Qi Z
PubMed: 42126515
Submit Comment

Comparing the value of dynamic versus static image-based tests of emotion recognition in neurodegenerative disease.

J Neuropsychol. 2026 May 13; Epub 2026 May 13
Authors: Ulugut H, Shany-Ur T, Quagletti A, Syed F, McEachen B, Callahan P, Rijpma MG, Antoniou R, Kramer JH, Miller BL, Rabinovici GD, Possin KL, Seeley WW, Rosen HJ, Gorno-Tempini ML, Sturm VE, Rankin KP
PubMed: 42126186
Submit Comment

Cognitive Impairment in Parkinson's Disease: Contributions from the Parkinson's Progression Markers Initiative.

Ann Neurol. 2026 May 13; Epub 2026 May 13
Authors: Weintraub D, Dobkin RD, York MK, Chahine LM, Tropea TF, Marek K, Parkinson's Progression Markers Initiative
PubMed: 42125954
Submit Comment

Comprehensive Characterization of 98 Chinese Cases of Genetic Creutzfeldt-Jakob Disease With T188K Mutation.

Ann Clin Transl Neurol. 2026 May 13; Epub 2026 May 13
Authors: Li CJ, Liang DL, Gao LP, Zhang WW, Zhou W, Ruhan A, Xu B, Cao RD, Xiao K, Chen C, Shi Q, Dong XP
PubMed: 42125878
Submit Comment

Effects of age and APOE ϵ4 genotype on the relationship between pulse pressure and executive function in older adults without Dementia.

J Int Neuropsychol Soc. 2026 May 13;:1-10. Epub 2026 May 13
Authors: Quiring ML, Edwards L, Bangen KJ, Ho EH, Carlsson CM, Galasko D, Weintraub S, Gershon R, Salmon DP
PubMed: 42124479
Submit Comment

The Glymphatic system: A dynamic regulator of brain health and therapeutic target.

Exp Neurol. 2026 May 13;:115825. Epub 2026 May 13
Authors: Wang X, Gao M, Sui S, Liu F, Tian W, Wu S, Ding J, Chao X, Xie X, Gu M, Hu T, Sun W
PubMed: 42134763
Submit Comment

Carboplatin alleviates astrocytic TDP-43 neurotoxicity by inhibiting NF-κB activation.

Eur J Pharmacol. 2026 May 13;1026:178968. Epub 2026 May 13
Authors: Song J, Lee S, Lee J, Gil Y, Kim T, Kim SY, Cha SJ, Kim HJ, Kim K
PubMed: 42134762
Submit Comment

The impact of long-term feeding with curcuminoids phospholipids enriched diet on disease progression of fALS.

Neurochem Int. 2026 May 13;197:106183. Epub 2026 May 13
Authors: Purushotham SS, Chesworth R, Keembiyage N, Münch G, Gyengesi E, Buskila Y
PubMed: 42134658
Submit Comment

TDP-43 expression in the cytoplasm leads to early synaptic and mitochondrial abnormalities in an inducible mouse model of ALS/FTD.

Neurochem Int. 2026 May 13;197:106180. Epub 2026 May 13
Authors: Vassallu F, López M, López Ambrosioni F, Casal J, Caltana L, Igaz LM
PubMed: 42134656
Submit Comment

Parkinson's Disease as a Disorder of Synaptic Raft Integrity: A Unified Explanation for Motor Subtypes and Non-motor Symptoms.

Neurochem Int. 2026 May 13;:106177. Epub 2026 May 13
Authors: Sakoda S
PubMed: 42134654
Submit Comment

The Influence of Blood Lipids on Cerebral Perfusion by Apolipoprotein E Status.

J Lipid Res. 2026 May 13;:101057. Epub 2026 May 13
Authors: Decker KP, Rizzi NA, Rigas Z, Awad C, Habash EM, Kramer MK, Cerjanic AM, Cohen ML, Johnson CL, Martens CR
PubMed: 42134547
Submit Comment

Tetramethylpyrazine improving cerebral microcirculation in Alzheimer's Disease mice.

Brain Res Bull. 2026 May 13;:111936. Epub 2026 May 13
Authors: Wu Q, Cui X, Liu X, Yuan X, Wang P, Li H, Xiu R
PubMed: 42134480
Submit Comment

Continuous-time causal distribution learning with identifiability for brain dynamic effective connectivity inference.

Med Image Anal. 2026 May 13;112:104124. Epub 2026 May 13
Authors: Wang Y, Chen L, Qiao C
PubMed: 42134283
Submit Comment

In vitro and in vivo inhibition of amyloid β aggregation by a Ru(II)-naphthalene diimide complex.

Dalton Trans. 2026 May 13; Epub 2026 May 13
Authors: Tiburcio MA, Cali MP, Pereira LM, Graminha AE, Atienza-Navarro I, Vendruscolo M, Garcia-Alloza M, Carlos RM
PubMed: 42132855
Submit Comment

Causal associations of dietary habits and blood metabolites with Parkinson's disease risk.

Food Funct. 2026 May 13; Epub 2026 May 13
Authors: Zhao J, Wei L, Zhao M, Sheng H, Yan X, Nie S, Huang Y
PubMed: 42132746
Submit Comment

Mutation-Driven Remodeling of the LRRK2 Kinase Free-Energy Landscape and Its Consequences for Conformational Transitions and Inhibitor Binding Affinity.

J Chem Inf Model. 2026 May 13; Epub 2026 May 13
Authors: Ghosh R, Bhanja KK, Patra N
PubMed: 42130234
Submit Comment

Age-dependent peripheral dissemination of α-synuclein seeds: mechanistic basis for blood-based early detection of Parkinson's disease.

Acta Neuropathol Commun. 2026 May 13; Epub 2026 May 13
Authors: Kuang Y, Mao H, Lin H, Dai W, Su Z, Luo Y, Zou WQ, Yang XL, Xu PY
PubMed: 42129944
Submit Comment

Clinical correlates of sleep profiles in dementia with Lewy bodies: a latent class approach.

Alzheimers Res Ther. 2026 May 13; Epub 2026 May 13
Authors: Renard L, Aveneau C, Götze K, Varnet O, Dieudonné A, Hourrègue C, Cognat E, Dumurgier J, Diard C, d'Ortho MP, Paquet C, Vrillon A
PubMed: 42129862
Submit Comment

Valosin-containing Protein is cargo in Amyloid Precursor Protein extracellular vesicles.

Cell Commun Signal. 2026 May 13; Epub 2026 May 13
Authors: Lu Y, Abdullah M, Healy LR, Yin T, Yesiltepe M, D'Adamio L, Tambini MD
PubMed: 42129847
Submit Comment

Molecular and statistical weaknesses of the p-tau217/Aβ1-42 plasma ratio for alzheimer's diagnosis.

J Mol Med (Berl). 2026 May 12;104(1)
Authors: Ferré CG, Pallàs M, Franco R
PubMed: 42115432
Submit Comment

α/Sulfonyl-γ-AApeptide foldamers mitigate Alzheimer's disease pathology by stabilizing transient helical domains in Aβ.

Nat Commun. 2026 May 12; Epub 2026 May 12
Authors: Liu H, Akhter F, Akhter A, Zhao X, Wang X, Yang H, Chen J, Xia X, Calcul L, He Y, Cao C, Ye L, Zhu D, Cai J
PubMed: 42115163
Submit Comment

Knockout of Rab27b exacerbates neuropathology in alpha-synuclein mouse models.

Acta Neuropathol Commun. 2026 May 12; Epub 2026 May 12
Authors: Scholz K, Gannon MA, Matheny L, Syed R, Stone WJ, Craig C, Ekkatine R, Yacoubian TA
PubMed: 42121002
Submit Comment

Porcine plasma-derived extracellular vesicles orchestrate multi-target neuroimmune reconfiguration to alleviate Alzheimer's disease pathology in a 5×FAD mouse model.

J Neuroinflammation. 2026 May 12; Epub 2026 May 12
Authors: Lu X, Jiang Y, Lin X, Zhang Y, Liu Q, Chen S
PubMed: 42120990
Submit Comment

Cell Cycle Dysfunction and Metabolic Alterations Consistent With Pathological Tau in Progressive Supranuclear Palsy Derived Fibroblasts.

Mol Neurobiol. 2026 May 12;63(1)
Authors: De Mori R, Ciaiola F, Nesci V, Gimenez J, de Bardi M, Pieroni L, de Stefano S, Borsellino G, Valle C, Ferri A, Stefani A, Mascioli D, Mancini M, Mercuri NB, Spalloni A, Schirinzi T, Longone P
PubMed: 42120786
Submit Comment

Early α-synuclein-mediated mitochondrial dysfunction in a human cell model of Parkinson's disease dementia.

Commun Biol. 2026 May 12; Epub 2026 May 12
Authors: Alfaidi MS, Wenger LM, Szebényi K, Stoker TB, He X, Fazal SV, Sebestikova J, Jassim A, Gilbertson RJ, Garza R, Jakobsson J, Spillantini MG, Barker RA, Kuan WL
PubMed: 42120738
Submit Comment

Somatic variants in microglia-like cells linked to Alzheimer's disease pathology.

Nat Aging. 2026 May 12; Epub 2026 May 12
Authors: Walters H
PubMed: 42120736
Submit Comment

Brain endothelial cell-derived extracellular vesicles (c-BEEVs) as a promising biomarker for brain vascular pathology and cognitive decline.

Nat Aging. 2026 May 12; Epub 2026 May 12
Authors: You T, Wang Y, Xu J, Zhao Y, Peng S, Han Q, Wang X, Zhang M, Shen W, Guo M, Zhang J, Yu H, Yu J, Dong Q, Cui M
PubMed: 42120733
Submit Comment

Associations between REM sleep EEG slowing and brain cholinergic denervation in aging and Mild Cognitive Impairment.

Mol Psychiatry. 2026 May 12; Epub 2026 May 12
Authors: André C, Bédard MA, Daneault V, Wickens R, Fliaguine O, Soucy JP, Gauthier S, Lorrain D, Bastien C, Hudon C, Marchi NA, Montplaisir J, Gosselin N, Carrier J
PubMed: 42120556
Submit Comment

Preformed fibrils of α-synuclein rapidly activate LRRK2 on early endosomes, driving Rab5 phosphorylation and disrupting endolysosomal and synaptic function.

NPJ Parkinsons Dis. 2026 May 12; Epub 2026 May 12
Authors: Zuo X, Chen Z, Chen XQ, Guan D, Shaw PX, Johnstone A, Becker A, Das U, Mobley WC
PubMed: 42120407
Submit Comment

Gpnmb defines a phagocytic state of microglia linked to cell death in prion disease mouse model.

Nat Commun. 2026 May 12; Epub 2026 May 12
Authors: Caredio D, Mariutti G, Polzer L, Gatta B, Cerisoli M, Laimeche Y, Miracca G, Droux J, El Amki M, Emmenegger M, Hruska-Plochan M, Wegener S, Polymenidou M, Schmitz M, Zerr I, De Cecco E, Aguzzi A
PubMed: 42120390
Submit Comment

Patterns and Trends of Glucose-Lowering Therapy in Alzheimer's Disease and Related Dementias.

Diabetes Obes Metab. 2026 May 12; Epub 2026 May 12
Authors: Tang H, Zhang B, Lu Y, Lu Y, Amaro A, Lu Y, Wolk DA, Chen Y
PubMed: 42119996
Submit Comment

Postnatal particulate matter exposure alters developmental milestones and brain gene expression in apoE transgenic mice in a sex- and genotype-dependent manner.

Neurotoxicology. 2026 May 12;114:103466. Epub 2026 May 12
Authors: Rodulfo-Cárdenas R, Biosca-Brull J, Barberà-Parada S, Gabaldón-Díaz R, Ruiz-Sobremazas D, Blanco J, Cabré M, Domingo JL, López-Granero C, Sanchez-Santed F, Colomina MT
PubMed: 42119734
Submit Comment

Age-adjusted neurofilament light chain cutoffs for diagnosing neurodegenerative dementia: a two-threshold machine learning approach.

Geroscience. 2026 May 12; Epub 2026 May 12
Authors: Gallingani C, Maramotti R, Carbone C, Vinceti G, Cossutti S, Iacovino N, Ballotta D, Salemme S, Urbano T, Bedin R, Chiari A, Zamboni G, Tondelli M
PubMed: 42118476
Submit Comment

Elevated levels of circulating plasma sPDGFRβ in cognitively impaired APOE4 carriers.

Geroscience. 2026 May 12; Epub 2026 May 12
Authors: Sagare AP, Lohman T, Ramirez I, Joe EB, Harrington MG, Chui HC, Schneider LS, Yassine HN, Ringman JM, Toga AW, Nation DA, Zlokovic BV
PubMed: 42118474
Submit Comment

STAT6-Mediated SOCS2 Alleviates Cognitive Impairments and Neuronal Damage in Alzheimer's Disease Rat Models and Aβ1-42-Stimulated HT-22 Cells.

Mol Neurobiol. 2026 May 12;63(1)
Authors: Liu Y, Peng L, Li M, Yan W, Xiang Q
PubMed: 42118457
Submit Comment

Mechanism of the N87D mutation in SOD1-atypical amyotrophic lateral sclerosis case report and literature review molecular mechanism of N87D mutation in SOD1.

Neurogenetics. 2026 May 12;27(1)
Authors: Pi C, Liu Y, Jia Z, Zhang M, Wang X, Zhao H, Dong Z, Yu S, Liu R
PubMed: 42118400
Submit Comment

From Molecular Networks to Medicines: Targeting Complexity in Alzheimer's Disease (AD) Therapy.

Mol Neurobiol. 2026 May 12;63(1)
Authors: Kumar R, Patel S, Mishra PS, Srivastava S, Sridhar SB, Shareef J, Sahu R, Tariq M, Uddin J, Muhsinah AB
PubMed: 42118396
Submit Comment

Aspirin as a neuroprotective scaffold in Alzheimer's disease: inflammation, oxidative stress, and future directions.

Mol Biol Rep. 2026 May 12;53(1)
Authors: S K, L G, S PP, C K
PubMed: 42118381
Submit Comment

Gut Microbiota Dysbiosis and Neuroinflammation in Alzheimer's Disease: a Systematic Review of Mechanistic Insights.

Mol Neurobiol. 2026 May 12;63(1)
Authors: Katsigianni S, Koutsouraki E
PubMed: 42118364
Submit Comment

Modeling human neurodegenerative disorders in Drosophila: strategies and translational opportunities.

Mol Biol Rep. 2026 May 12;53(1)
Authors: Mohamed SA, Badr OA
PubMed: 42118343
Submit Comment

Molecular profiling of alpha-synuclein pathology and seeding activity in Parkinson's disease.

Acta Neuropathol. 2026 May 12;151(1)
Authors: Kaya ZB, Amerna D, Susarla A, Lim MJ, Bregendahl M, Sekiya H, DeTure M, Ross OA, Dickson DW, Boschen SL, McLean PJ
PubMed: 42118167
Submit Comment

Plasma Phosphorylated Tau217-A Pivotal Plasma Biomarker for Predicting the Progression of Mild Cognitive Impairment to Alzheimer's Disease: A Reanalysis of ADNI Data.

J Clin Exp Neuropsychol. 2026 May 12;:1-17. Epub 2026 May 12
Authors: Lian Q, Sun Q, Han X, Ma H, Guo J, Wen B, Wang P, Li R, Shan A, Cui T, Gong J, Sun W, Wei C, Alzheimer’s Disease Neuroimaging Initiative
PubMed: 42117479
Submit Comment

White matter lesions disrupt cholinergic pathways important for cognition in Parkinson's disease.

Brain. 2026 May 12; Epub 2026 May 12
Authors: Carli G, Brown T, Michalakis F, Biddix A, Roytman S, Vangel R, Van Hout A, Kanel P, Scott P, Albin RL, Bohnen NI
PubMed: 42117428
Submit Comment

Mechanism of Aggregation of the NACore of α-Synuclein: Stable Oligomer Formation Competes with Fibril Formation with Implications for the Etiology of Parkinson's Disease.

J Am Chem Soc. 2026 May 12; Epub 2026 May 12
Authors: Jin Y, Ganguly P, Wessel L, Zhu Z, Rijs AM, Shea JE, Buratto SK, Bowers MT
PubMed: 42117267
Submit Comment

[Effect of medicated-thread moxibustion of Zhuang medicine on amnestic mild cognitive impairment with sleep disorder and its influence on event-related potential P300].

Zhongguo Zhen Jiu. 2026 May 12;46(5):704-712. Epub 2026 Feb 26
Authors: Zhao L, Huang N, Zhou Y, Zhou L, Huang D, Huang X
PubMed: 42116773
Submit Comment

A novel nasal mucosal peptide-modified co-delivery system for ginsenoside Rg1, Rb1, and notoginseng saponin R1 in the amelioration of AD.

J Nanobiotechnology. 2026 May 12; Epub 2026 May 12
Authors: Li Y, Hu C, Xia C, Wang X, Zhou X, Xu R, Li Y, Mo F, Zhao B, Xu L, Zhu C, Chen Z
PubMed: 42116113
Submit Comment

Differential cholinergic white matter microstructural alterations in multiple system atrophy and Parkinson's disease.

Neurobiol Dis. 2026 May 12;:107449. Epub 2026 May 12
Authors: Rong S, Yang R, Li Z, Cui X, He C, Zhang P, Li Y, Luo Q, Gao Z, Du T, Zhang Y, Cai R, Liu Z, Vyslouzilova L, Teipel SJ, Ferreira D, Nemy M, Li H, Wang L, Cai M, Zhang Y
PubMed: 42128307
Submit Comment

Glycocalyx and Basal Lamina in Neurological Disorders.

Matrix Biol. 2026 May 12;:102015. Epub 2026 May 12
Authors: Nasrollahi A, Yurchenco PD, Yao Y
PubMed: 42128066
Submit Comment

Secreted GPNMB enhances uptake of fibrillar alpha-synuclein in a non-cell-autonomous process that can be blocked by anti-GPNMB antibodies.

Neuron. 2026 May 12; Epub 2026 May 12
Authors: Carceles-Cordon M, Brody EM, Boucher ML, Gallagher MD, Skrinak RT, Unger TL, Penner CK, Berndt AJ, Das S, Lam K, Jaenisch R, Van Deerlin V, Lee EB, Brunden K, Luk KC, Chen-Plotkin AS
PubMed: 42127911
Submit Comment

High-throughput screening approach identifies substrate-selective Hsp104 variants that counter amyloid seeding with diminished off-target effects.

Mol Cell. 2026 May 12; Epub 2026 May 12
Authors: Ryan JJ, Miller KR, Puri A, Sprunger ML, Bochantine MM, Lopez A, Chen S, Bao A, Ling C, Xu A, Bell B, Sohn BS, Li L, Chang C, Mohammed K, Staller MV, Jackrel ME
PubMed: 42127909
Submit Comment

S-acylation of TDP43 regulates its condensation in amyotrophic lateral sclerosis.

Mol Cell. 2026 May 12; Epub 2026 May 12
Authors: Xu W, Li H, Zhang W, Bai G, Shen C, Zhang K
PubMed: 42127907
Submit Comment

Integrating molecular representations for machine learning-based virtual screening of Glutaminyl Cyclase inhibitors.

J Mol Graph Model. 2026 May 12;146:109441. Epub 2026 May 12
Authors: Ha HM, Tung HT, Anh NV, Cong NT, Hang NT, Phuong NV
PubMed: 42127661
Submit Comment

AI for Relational Reconnection and Social Support in Alzheimer's Disease: A Conceptual Framework for Socially Embedded Systems.

Gerontologist. 2026 May 12; Epub 2026 May 12
Authors: Zhang C
PubMed: 42121397
Submit Comment

Neuroprotective effects of quercetin in animal models of neurodegenerative diseases: A systematic review and meta-analysis.

J Sci Food Agric. 2026 May 12; Epub 2026 May 12
Authors: Cho IH, Putra HM, Jung CW, Hyun GH, Jang HH, Hwang IG, Kwon SW
PubMed: 42121268
Submit Comment

Comparative performance of semi-quantitative methods for amyloid deposition in preclinical autosomal dominant Alzheimer's disease.

Alzheimers Res Ther. 2026 May 12; Epub 2026 May 12
Authors: Zhou Z, Gao J, Wang Q, Wang Q, Liu L, Zhang X, Li C, Liu J, Wei Y, Zhang S, Wang R, Jia J, Fu L
PubMed: 42121220
Submit Comment

Blood biomarkers of Alzheimer's disease and 15-year decline in cognitive and motor functions in older adults.

J Intern Med. 2026 May 12; Epub 2026 May 12
Authors: Pinardi E, Grande G, Ornago AM, Valletta M, Rizzuto D, Fredolini C, Dale M, Laukka EJ, Mecocci P, Winblad B, Fratiglioni L, Bellelli G, Vetrano DL
PubMed: 42121219
Submit Comment

Calbindin-D28k deficiency mediates tau-driven hippocampal hyperexcitement and cognitive impairment.

Transl Neurodegener. 2026 May 12;15(1)
Authors: Gao Y, Tao X, Wang Y, Wang Y, Li H, Yu Y, Tu M, Liu Y, Zhou J, Li Y, Wei W, Wang X, Zheng J, Zhang Y, Xu H, Wang JZ
PubMed: 42121190
Submit Comment

Residential green spaces and neurodegenerative diseases in middle-aged and older adults: a systematic review and dose-response meta-analysis.

Arch Public Health. 2026 May 12; Epub 2026 May 12
Authors: Shen C, Su J, Liu L, Li J, Zhao X, Wang Z, Jiang Y, Zhao D
PubMed: 42121182
Submit Comment

A deep hybrid CNN-BiLSTM-BiGRU architecture with explainability for mild cognitive impairment detection using EEG.

Brain Inform. 2026 May 11; Epub 2026 May 11
Authors: Tokdar A, Agarwal L, Chatterjee S, Sukriti
PubMed: 42108320
Submit Comment

iS2C2: a cointelligent platform for mechanistic discovery of disease cellular crosstalk.

Signal Transduct Target Ther. 2026 May 11;11(1)
Authors: Sheng J, Ahn JY, Yang L, Wan Z, Qi S, Yu X, Xu Z, Cao Y, Vasquez M, Irfan A, Zhu Y, Zhao H, Yin Z, Zhu Y, Ding Y, Faridar A, Wang L, Liu F, Wang H, Ji Z, Mao D, Chan M, Kermany D, Dong W, Kim DY, Zhang XH, Wong ST
PubMed: 42108258
Submit Comment

Beyond association: A quantitative analysis of the infectious burden in Alzheimer's disease.

J Alzheimers Dis. 2026 May 11;:13872877261447530. Epub 2026 May 11
Authors: Bender O, Shemesh OA, Bar DZ
PubMed: 42115784
Submit Comment

Resolving protein condensates and aggregates in vivo by boxcar-enhanced Fluorescence-detected mid-Infrared photothermaL Microscopy (FILM).

Commun Chem. 2026 May 11; Epub 2026 May 11
Authors: Weinberg B, Guo Z, Tang R, Ao J, Yin J, Ding G, Blute TA, Savini M, Chiesa G, Wang W, Good M, Wang MC, Cheng JX
PubMed: 42115735
Submit Comment

Shared and distinct lipid profiles in amygdala from sporadic and GBA-associated Parkinson's diseases.

NPJ Parkinsons Dis. 2026 May 11; Epub 2026 May 11
Authors: Muñoz SS, Marlet FR, Dreier JE, Bilgin M, Schott K, Neergaard KB, Bezard E, Dehay B, Jaunmuktane Z, Maeda K, Galvagnion C
PubMed: 42115606
Submit Comment

CPNE1 modulates Parkinson's disease risk through peripheral immune cell function: a cross-tissue and single-cell causal inference study.

Mamm Genome. 2026 May 11;37(1)
Authors: Zhao J, Fu J, Zhang J, Zhang Z, Bai X, Yao L
PubMed: 42115417
Submit Comment

Cognitive and behavioral disturbances in PSP and MSA: clinical features and imaging correlates.

J Neural Transm (Vienna). 2026 May 11; Epub 2026 May 11
Authors: Ruiz-Barrio I, Horta-Barba A, Martinez-Horta S, Kulisevsky J, Pagonabarraga J
PubMed: 42115350
Submit Comment

AI-powered evaluation of dementia severity based on clinical data and visual scoring systems (MTA, ERICA, GCA) from MRI.

Sci Rep. 2026 May 11; Epub 2026 May 11
Authors: Naing LT, Kunapinun A, Dailey MN, Patanasantichai R, Buathong S, Keatmanee C, Wongsripuemtet J, Rattanabannakit C, Senanarong V, Ekpanyapong M, Songsaeng D
PubMed: 42115238
Submit Comment

Application of resting-state EEG theta /alpha power ratio analysis for diagnosing amnestic mild cognitive impairment.

Sci Rep. 2026 May 11; Epub 2026 May 11
Authors: Liang Y, Li P, Wang Y, Jing F, Dong C, Zhao L
PubMed: 42115191
Submit Comment

Aggregation in gut: on the link between neurodegeneration and bacterial functional amyloids.

NPJ Biofilms Microbiomes. 2026 May 11; Epub 2026 May 11
Authors: Wojciechowska AW, Wojciechowski JW, Zielinska K, Soeding J, Kosciolek T, Kotulska M
PubMed: 42115189
Submit Comment

Nanoparticle-enriched mass spectrometry enables comprehensive plasma proteomics and reveals novel candidates for mild cognitive impairment.

Sci Rep. 2026 May 11; Epub 2026 May 11
Authors: Kim JH, Kwon OK, Jang WC, Jeong HK, Lee KJ, Oh C, Lee KM, Choi KH, Han X, Lee SJ, Lee SB
PubMed: 42115184
Submit Comment

Comparative effectiveness of recreational therapies on cognition, neuropsychiatric symptoms, and psychosocial outcomes in individuals with mild cognitive impairment and dementia: A network meta-analysis.

Int J Nurs Stud. 2026 May 11;180:105553. Epub 2026 May 11
Authors: Aini N, Su PY, Sung CM, Chen R, Chiang KJ, Chang LF, Maharani PA, Martini NM, Arifin H, Chou KR
PubMed: 42114453
Submit Comment

Mechanisms and Therapeutic Targeting of the Gut Microbiota-Immune-Brain Axis in Alzheimer's Disease.

Immunol Invest. 2026 May 11;:1-31. Epub 2026 May 11
Authors: Wang S, Yuan X, Wang T, Yang M, Dong P, Han H
PubMed: 42113681
Submit Comment

Incidence and Prevalence of Dementia With Lewy Bodies: A Systematic Review and Meta-Analysis.

JAMA Neurol. 2026 May 11; Epub 2026 May 11
Authors: Urso D, Giannoni-Luza S, Giannelli T, Brayne C, Ray N, Logroscino G
PubMed: 42113545
Submit Comment

Genetic Testing by Age at Onset in Parkinson Disease.

JAMA Neurol. 2026 May 11; Epub 2026 May 11
Authors: Balck A, Vollstedt EJ, Westenberger A, Lange LM, Trinh J, Kasten M, Lohmann K, Brüggemann N, Trenkwalder C, Mollenhauer B, Alcalay R, Galvelis KG, Beck JC, Bauer P, Klein C, König IR, Global Parkinson’s Genetics Program (GP2), the ROPAD Study Group, and the PDGENEration Study
PubMed: 42113543
Submit Comment

Exploratory serum biomarker profiling in idiopathic REM sleep behavior disorder: evidence of early neurodegenerative signatures: a pilot study.

Sleep Breath. 2026 May 11;30(3)
Authors: Torres DM, Pereira FH, da Silva Viana M, Ramos MM, Cunha EG, de Araújo Melo LJ, Sobreira ES, Lopes FC, Frota AF, Soares MV, de-Almeida RT, Braga-Neto P, Macedo DS, Sobreira-Neto MA
PubMed: 42113395
Submit Comment

A53T α-Synuclein Expression is Associated with Altered Dopaminergic-Like Differentiation and Reduced DNA Topoisomerase IIβ Levels in an In Vitro Model of Parkinson's Disease.

Mol Neurobiol. 2026 May 11;63(1)
Authors: Selim A, Avşar T, Neğiş Y, Işık S
PubMed: 42113340
Submit Comment

Spastic paraparesis linked to a rare presenilin-1 mutation.

Neurogenetics. 2026 May 11;27(1)
Authors: Teles C, Durães J, Faustino P, Baldeiras I, Gens H, Pereira MT, Almeida MR, Santana I
PubMed: 42113316
Submit Comment

Exosomes in Amyloid Propagation-Roles in Neurodegeneration.

Mol Neurobiol. 2026 May 11;63(1)
Authors: Mishra R, Upadhyay A
PubMed: 42113315
Submit Comment

Subjective and objective cognition in early-stage, treatment-naïve Parkinson's disease: Relationships with mood.

Neuropsychology. 2026 May 11; Epub 2026 May 11
Authors: Varela JL, Margolis SA, Akbar U, Prieto S, Kenney LE, Daiello LA, Davis JD
PubMed: 42113176
Submit Comment

Fecal miRNome and Proteome Profiling Uncovers Stage-Specific Biomarkers of Alzheimer's Disease in 3×Tg-AD Mice.

Cell Mol Neurobiol. 2026 May 11; Epub 2026 May 11
Authors: Vitali R, Tanno B, Casciati A, Palone F, Pieroni L, Morotti M, Santoro M, Fratini E, Pazzaglia S, Podda MV, Mancuso M
PubMed: 42113045
Submit Comment

Perspectives in dementia risk reduction - food for thought.

Neurodegener Dis Manag. 2026 May 11;:1-12. Epub 2026 May 11
Authors: Rasmussen J
PubMed: 42112907
Submit Comment

Development and Evaluation of Intranasal Nanostructured Lipid Carriers Encapsulating Donepezil HCl and Caesalpinia bonduc Seed Extract for Targeting Alzheimer's Disease: in vitro and in vivo evaluation.

J Drug Target. 2026 May 11;:1-26. Epub 2026 May 11
Authors: Tekade A, Shinde R, Nimbalkar J, Kadam P, Aswar M, H N S
PubMed: 42112871
Submit Comment

Alzheimer's Disease Co-Pathology and Cognitive Impairment in Amyotrophic Lateral Sclerosis.

Ann Neurol. 2026 May 11; Epub 2026 May 11
Authors: Kasper E, Lehto A, Jürs A, Nordmann N, Peters O, Hellmann J, Priller J, Spruth EJ, Petzold GC, Voigt I, Weydt P, Bernsen S, Dinter E, Falkenburger B, Günther R, Düzel E, Glanz W, Synofzik M, Beichert L, Spottke A, Wagner M, Brosseron F, Schmid MC, Halle A, Herms J, Schneider A, Teipel S, Prudlo J, Neumann M, Hermann A
PubMed: 42112660
Submit Comment

Latinos' appraisals of and responses to memory problems.

J Health Psychol. 2026 May 11;:13591053261442545. Epub 2026 May 11
Authors: Siegel K, Cabán M, Wetmore JB, Ottman R
PubMed: 42109151
Submit Comment

The interplay of APOE genotype, plasma levels, and cognitive functions in middle-aged adults with a parental history of Alzheimer's disease.

World J Biol Psychiatry. 2026 May 11;:1-14. Epub 2026 May 11
Authors: Mattar YA, Refaat O, El-Makawi S, Medhat E, Khalifa D
PubMed: 42109080
Submit Comment

Influence of local spontaneous activity and hippocampal volume on the relationship between APOE genotype, ATN biomarkers, and cognitive function across the Alzheimer's disease spectrum.

Chin Med J (Engl). 2026 May 11; Epub 2026 May 11
Authors: Zhu Y, Wang A, Wu Y, Yang L, Duan Y, Zhao Y, Zhao X, Hu W, Qun S, Alzheimer’s disease Neuroimaging Initiative
PubMed: 42108496
Submit Comment

Neuroinvasion Pathways of Treponema denticola and Its Role in Amyloidogenesis and Neuroinflammation: A Systematic Review.

Microb Pathog. 2026 May 11;:108554. Epub 2026 May 11
Authors: Semnani PM, Afiyat S, Tabibian SS, Ariaee A, Keshtehgar H, Ahmadi S, Eslami M
PubMed: 42119956
Submit Comment

Plasma p-Tau217 and Aβ42/40 for Identifying Amyloid PET Positivity in Cognitively Unimpaired Asian Individuals: A Systematic Review and Meta-Analysis.

Ageing Res Rev. 2026 May 11;:103173. Epub 2026 May 11
Authors: Terao I, Kodama W
PubMed: 42119901
Submit Comment

Ameliorative effect of AYUSH formulation against scopolamine induced learning and memory impairment in rat via attenuation of oxidative stress, neuroinflammation, acetylcholinesterase inhibition and Aβ plaques.

J Ethnopharmacol. 2026 May 11;:121853. Epub 2026 May 11
Authors: Samal M, Zahiruddin S, Srivastava V, Penumallu NR, Parveen B, Parveen R, Ansari SH, Ahmad S
PubMed: 42119864
Submit Comment

Immune receptor LAG3 regulates microglia function during Alzheimer's disease.

Neurobiol Dis. 2026 May 11;:107447. Epub 2026 May 11
Authors: Perl AT, Wu J, Dong JD, Brooks AM, Yoblinski AR, Vierling TT, Li JL, Ruby DR, Radzicki D, Dudek SM, Cushman JD, Gjoneska E
PubMed: 42119858
Submit Comment

Offset Conduction Velocity Reveals Prognostic Slowing of Motor Axons in Amyotrophic Lateral Sclerosis.

Muscle Nerve. 2026 May 11; Epub 2026 May 11
Authors: Shimizu T, Myojin H, Bokuda K, Kawazoe T, Morishima R, Kimura H, Takahashi K, Nakayama Y
PubMed: 42116669
Submit Comment

Rituximab Beyond Oncology: Targeting B-Cell-Mediated Immunomodulatory Therapy in Neurodegenerative and Neuropsychiatric Disorders.

Immunopharmacol Immunotoxicol. 2026 May 11;:1-77. Epub 2026 May 11
Authors: Saha T, Vats T, Mehan S
PubMed: 42116599
Submit Comment

Systemic interleukin signaling and Alzheimer's disease risk: A two-sample cross-replication Mendelian randomization study.

J Alzheimers Dis. 2026 May 11;:13872877261449516. Epub 2026 May 11
Authors: Ahmed HM, Ali Siddique M, Shaheer Ul Islam M, Khan Lodhi AR, Owais M, Rehman UU
PubMed: 42116542
Submit Comment

Stakeholder perspectives on the potential benefits, risks, and implications of an interactive cognitive monitoring app for the identification and monitoring of cognitive decline in adults at risk of dementia.

BMC Health Serv Res. 2026 May 11; Epub 2026 May 11
Authors: Syukriyah D, Hulme C, Davis C, Llewellyn DJ, Allan L, Aarsland D, Ballard C, Fox C, Lamb SE, Corbett A
PubMed: 42116097
Submit Comment

A longitudinal analysis of T1-weighted MRI features associated with progression from mild cognitive impairment to Alzheimer's disease.

BMC Med Imaging. 2026 May 11; Epub 2026 May 11
Authors: Wang Y, Song W, Yang X, Meng W, Ma Y, Wang A, Guo G, Zhang Z, Li Z, Han H, Wang S, Shi F
PubMed: 42115951
Submit Comment

Comparison of hippocampus, entorhinal cortex, and amygdala volumes in individuals with Alzheimer's disease, mild cognitive impairment, and healthy individuals.

J Alzheimers Dis. 2026 May 11;:13872877261450574. Epub 2026 May 11
Authors: Senol D, Secgin Y, Kaya S, Ozturk O, Harmandaoglu O, Alzheimer’s Disease Neuroimaging Initiative
PubMed: 42115829
Submit Comment

Blood-based biomarkers for Alzheimer's disease. 'Treat the test, not the patient?'; are we ready to defy Osler?

Expert Rev Mol Diagn. 2026 May 10;:1-5. Epub 2026 May 10
Authors: Connon P, McKenna MC, Black SE, Masellis M
PubMed: 42107929
Submit Comment

A Skull Bone Marrow-to-Brain Axis Links Osteoblastic Activity to Myeloid Cell Trafficking, Cerebral Blood Flow, and Cognition in Alzheimer's Progression.

Adv Sci (Weinh). 2026 May 10;:e75622. Epub 2026 May 10
Authors: Xiong L, Sun D, Guo HH, Lee D, Liu Z, Mei L, Xiong WC
PubMed: 42107073
Submit Comment

Recruitment Strategies across the Spectrum of Neuronal Synuclein Disease.

Ann Neurol. 2026 May 10; Epub 2026 May 10
Authors: Siderowf A, Heathers LE, Fabrizio K, Kuhl MM, Kopil CM, Flagg E, McMahon BA, Coffey CS, Bright A, Totten M, Lemon LP, Bryan E, Prakash N, Pavese N, Bloem BR, Alcalay RN, Mirelman A, Stefanis L, Okubadejo N, Tolosa E, Tanner CM, Simuni T, Chowdhury S, Tropea TF, Marek K, Foroud T, Parkinson's Progression Markers Initiative
PubMed: 42108682
Submit Comment

Expanding PPMI through Remote Data Acquisition and Analysis: Early Success and Future Growth with myPPMI.

Ann Neurol. 2026 May 10; Epub 2026 May 10
Authors: Tanner CM, Stanley CE, Brown EG, Chahine LM, Weintraub D, Dobkin RD, Poewe W, Tolosa E, Marras C, Schade S, Chou KL, Pavese N, Coffey CS, Brumm MC, Kurth R, Noyce AJ, Gonzalez-Latapi P, Matthews-McGee A, Korell M, Meng C, Chen X, Racelo L, Ricci J, Fitzgerald C, Rigby NH, Battles JA, Carley JK, Singh Z, Kruchkow L, McMahon BA, Flagg E, Lemon LP, Talarico JM, Brodkin K, Destro C, Kuhl MM, Fabrizio K, Marek K, Tropea TF, Parkinson's Progression Markers Initiative
PubMed: 42108656
Submit Comment

The social value of lecanemab for patients with early Alzheimer's disease in Japan.

J Alzheimers Dis. 2026 May 10;:13872877261447312. Epub 2026 May 10
Authors: Igarashi A, Azuma-Kasai M, Tani M, Utsumi T, Shibahara H, Inoue S, Rothwell S, Kamanaka G, Sakata Y, Hiyoshi H, Tomita K
PubMed: 42108615
Submit Comment

A novel synaptic compartmentalization failure framework for neurodegeneration.

J Alzheimers Dis. 2026 May 9;:13872877261449379. Epub 2026 May 9
Authors: Panigrahi B
PubMed: 42104730
Submit Comment

A Systematic Review on Disease-Modifying Therapies in Parkinsonian Disorders.

Clin Pharmacol Ther. 2026 May 9; Epub 2026 May 9
Authors: Eijsvogel PP, Smits LM, Kremer PH, Groeneveld GJ
PubMed: 42104724
Submit Comment

Real-world clinical profile of individuals with cerebrospinal fluid Aβ-/pTau181.

J Alzheimers Dis. 2026 May 9;:13872877261445561. Epub 2026 May 9
Authors: Keret O, Xia T, Wilkins S, Ncube LN, Smaw B, Xiong Y, Gandy S, Pereira A, Georges N, Elahi FM
PubMed: 42104723
Submit Comment

Early diagnosis of Alzheimer's disease through handwriting analysis and deep learning: A review.

J Alzheimers Dis. 2026 May 9;:13872877261446573. Epub 2026 May 9
Authors: Tang Q, Liu J, Fan C, Zhang X, Zhang C, Qi H
PubMed: 42104715
Submit Comment

Letter to the Editor: Comments on "Neural network disruptions between default mode network and salience network in mild cognitive impairment with neuropsychiatric symptoms".

Int Psychogeriatr. 2026 May 9;:100219. Epub 2026 May 9
Authors: Harihar SA, Kurhade AS, Waware SY
PubMed: 42108145
Submit Comment

PACAP in Parkinson's disease: A multifunctional neuropeptide at the crossroad of autophagy, inflammation, and metabolic repurposing.

Neuropharmacology. 2026 May 9;296:111013. Epub 2026 May 9
Authors: Hassan ME, Al-Kuraishy HM, Fawzy MN, Hussain NR, Al-Gareeb AI, Rashwan EK, Albuhadily AK, Batiha GE
PubMed: 42107921
Submit Comment

Microglia crosstalk with T cells in neurodegenerative diseases: pathogenesis and treatment targets.

Int Immunopharmacol. 2026 May 9;182:116781. Epub 2026 May 9
Authors: Chen G, Zhao C, Wang C, Chen G, Shi J, Chen H
PubMed: 42107892
Submit Comment

Longitudinal metabolomic profiling of biogenic amines in plasma and CSF, and their correlation, reveals sex-specific and age changes in TgF344 Alzheimer's disease transgenic and wildtype rats.

Fluids Barriers CNS. 2026 May 9;23(1)
Authors: Yin C, Nelen I, Harms A, Hartman R, Bos S, Nijgh-van Kooij C, Hankemeier T, Kindt A, de Lange E
PubMed: 42106823
Submit Comment

A nomogram combined substantia nigra hyperechogenicity with third ventricular width assessed by transcranial sonography in prediction Parkinson's disease-related cognitive impairment.

BMC Med Imaging. 2026 May 9; Epub 2026 May 9
Authors: Yang QH, Hou C, Li MX
PubMed: 42106687
Submit Comment

Bacterial polar metabolites modulate β-amyloid toxicity and cholinergic dysfunction in models of Alzheimer's disease.

Sci Rep. 2026 May 9; Epub 2026 May 9
Authors: Santos AC, Corrêa JL, Duarte RM, Malta SM, Rodrigues TS, de Oliveira Santos D, de Faria PR, do Prado Mascarenhas FN, Zanon RG, Cassemiro NS, Carollo CA, Espindola FS, Martins MM, Mendes-Silva AP, Bonetti AM, Dos Santos AR, Ueira-Vieira C
PubMed: 42106468
Submit Comment

Sound-evoked auditory neurophysiological signals are a window into prodromal functional differences in a preclinical model of Alzheimer's disease.

Sci Rep. 2026 May 9; Epub 2026 May 9
Authors: Aydin AG, Manoj P, Ramadan F, Rajan S, Youssef E, Torres EB, Bieszczad KM
PubMed: 42106438
Submit Comment

Mapping research trends and gaps in cognitive dysfunction in Parkinson's disease: A bibliometric and scientometric analysis.

J Health Psychol. 2026 May 9;:13591053261442336. Epub 2026 May 9
Authors: Naeim M, Narimani M, Mikaeili N
PubMed: 42105346
Submit Comment

Neuroprotective role of phenolic acids: mechanistic insights into cognitive decline and neurodegenerative disorder.

Nutr Neurosci. 2026 May 9;:1-25. Epub 2026 May 9
Authors: Balwant Patil K, Sugunan S, Padiyar A, Mishra AK, Jain S
PubMed: 42105317
Submit Comment

Molecular and genetic landscape of amyotrophic lateral sclerosis in Latin America: a scoping review of pathogenic hypotheses and ancestral heterogeneity.

Amyotroph Lateral Scler Frontotemporal Degener. 2026 May 9;:1-9. Epub 2026 May 9
Authors: Flores SV, Lillo P, Briceño-Moya J, Pedro AP
PubMed: 42105306
Submit Comment

Targeting the NLRP3 inflammasome with antibody-based Therapeutics for chronic neurodegenerative diseases.

Expert Opin Ther Targets. 2026 May 9; Epub 2026 May 9
Authors: Sandhu JK, Tanha J, Arbabi-Ghahroudi M
PubMed: 42105291
Submit Comment

Lipid metabolism, neuroinflammation, and oxidative stress in Alzheimer disease: an integrated mechanistic review.

Acta Neurol Belg. 2026 May 9; Epub 2026 May 9
Authors: Lai L, Tang Y, Song G, Long Y, Chen C, Chen C, Li W
PubMed: 42105174
Submit Comment

Abnormal Amyloidogenesis Identified in Plasma of Patients with Spinocerebellar Ataxia Type 12.

Cerebellum. 2026 May 9;25(3)
Authors: Banerjee R, Sengupta S, Rungta J, Ansari S, Banerjee S, Biswas B, Pal R, Chattarji S, Choudhury S, Kumar H
PubMed: 42105155
Submit Comment

Differentiation of normal pressure hydrocephalus from alzheimer's and Parkinson's Diseases using the splenial angle measured on brain CT: diagnostic performance and reliability study.

Neuroradiology. 2026 May 9; Epub 2026 May 9
Authors: Kaya M, Konukoglu O, Genç H, Cindemir E, Onay M
PubMed: 42105113
Submit Comment

Efficacy and safety of GLP-1 receptor agonists in Parkinson's disease: a systematic review and meta-analysis of randomized clinical trials.

Neurol Sci. 2026 May 9;47(6)
Authors: Mendonça MF, Interaminense AC, do R Barros GS, Rabelo LA, de Oliveira PG, Sales RF, de C Lyra AM, de S E Silva HR
PubMed: 42105060
Submit Comment

Clinical patterns in social cognition & personality changes in progressive supranuclear palsy.

J Neurol. 2026 May 9;273(6)
Authors: Hebron LP, Wever LM, Callahan P, Rijpma MG, Antoniou R, Hirst RB, Brown LM, Kramer JH, Seeley WW, Gorno-Tempini ML, Rosen H, Miller BL, Rankin KP
PubMed: 42104994
Submit Comment

Galectin-3 in microglia mediates neuroinflammation-induced cognitive dysfunction via selective elimination of excitatory synapses in hippocampal CA1.

Brain Res. 2026 May 9;1887:150382. Epub 2026 May 9
Authors: Wu HP, Hu XY, Liu K, He QL, Zhu SY, Shi JY, Yang JJ, Fan D, Ji MH
PubMed: 42114797
Submit Comment

Proteomic analysis in Alzheimer's disease and other dementias: a focus on sex-specific differences.

Alzheimers Res Ther. 2026 May 8; Epub 2026 May 8
Authors: Comas-Albertí A, Lladó A, Esteller-Gauxax D, Borrego-Écija S, Falgàs N, Dakterzada F, Pérez-Millan A, Puey R, Collet-Romà T, Guillén N, Massons M, Tort-Merino A, Augé JM, Fernandez-Villullas G, Bosch B, Ruiz-García R, Naranjo L, Balasa M, Piñol-Ripoll G, Antonell A, Sánchez-Valle R
PubMed: 42104459
Submit Comment

ODIN Biobank: a Danish cohort for dementia research- cohort profile.

BMJ Open. 2026 May 8;16(5):e114084.
Authors: Laugesen K, Skjærbæk C, Okkels N, Møller HJ, Borghammer P, Gottrup H, Parkner T
PubMed: 42103387
Submit Comment

King's stages of amyotrophic lateral sclerosis: an 18F-FDG-PET study of brain connectivity.

Brain. 2026 May 8; Epub 2026 May 8
Authors: Di Pede F, Cabras S, Manera U, Vasta R, Zocco G, Minerva E, Matteoni E, De Mattei F, Pellegrino G, Palumbo F, Pascariu D, Callegaro S, Maccabeo A, Polverari G, Martino A, Giuliani A, Moglia C, Calvo A, Chiò A, Pagani M, Canosa A
PubMed: 42102258
Submit Comment

A Proline-Rich-Domain-Binding Single Domain Antibody Selectively Inhibits RNA-Induced Phase Separation of Tau.

ACS Chem Neurosci. 2026 May 8; Epub 2026 May 8
Authors: Thiou S, Martin L, Manousaki E, Nguyen M, Mortelecque J, Heidsieck L, Cantrelle FX, Blum D, Buée-Scherrer V, Buée L, Landrieu I, Dupré E, Danis C
PubMed: 42102067
Submit Comment

Utility of the 4-meter backward walking speed test in older adults with neurodegenerative diseases.

Ir J Med Sci. 2026 May 8; Epub 2026 May 8
Authors: Seydi KA, Kaya D, Yavuz I, Mahser AC, Mutlay F, Dost FS, Isik AT
PubMed: 42101771
Submit Comment

Plasma pTau181 is associated with subjective cognitive concerns but not objective cognitive decline or structural brain integrity measures in midlife.

Geroscience. 2026 May 8; Epub 2026 May 8
Authors: Barrett-Young A, Cawston EE, Ryan B, Abraham WC, Ambler A, Anderson T, Cheyne K, Goodin E, Hogan S, Houts RM, Ireland D, Knodt AR, Kokaua J, Melzer TR, Ramrakha S, Sugden K, Williams B, Wilson P, Caspi A, Hariri AR, Moffitt TE, Poulton R, Theodore R
PubMed: 42101744
Submit Comment

Placebo-controlled three-armed pilot trial of Escitalopram or Nortriptyline for depressive symptoms in Parkinson's disease (ADepT-PD).

J Neural Transm (Vienna). 2026 May 8; Epub 2026 May 8
Authors: Schrag A, Embleton-Thirsk A, Carroll C, Serfaty M, Duncan G, Molloy S, Whipps J, McLennan B, Lewis G
PubMed: 42101650
Submit Comment

Streamlining Alzheimer's disease diagnosis: real-world validation of two-cut-off diagnostic models based on plasma p-tau/Aβ42 ratios.

J Neurol. 2026 May 8;273(6)
Authors: Poli M, Bonomi CG, Di Donna MG, Barberis I, Ginevra EL, Nuccetelli M, Bernardini S, Centonze D, Martorana A, Motta C
PubMed: 42101517
Submit Comment

Compatibility of Acorus tatarinowii Schott and Polygala tenuifolia Willd. alleviate Alzheimer's disease through regulating Nos2-mediated calcium signaling pathway.

Neurochem Res. 2026 May 8;51(3)
Authors: Zhou B, Wu X, Wang J, Li L, Xu H, Shao W
PubMed: 42101516
Submit Comment

Biomaterials and Nanoparticle-Based Therapeutics in Neurodegenerative Diseases: Bridging the Gap Between Innovation and Translation.

ACS Chem Neurosci. 2026 May 8; Epub 2026 May 8
Authors: Panchal D, Solanki D, Solanki R, Yadav AK, Bhatia D, Yadav P
PubMed: 42101470
Submit Comment

A comprehensive systematic review of human trials investigating herbal treatments for Alzheimer's disease and dementia.

Acta Neuropsychiatr. 2026 May 8;:1-55. Epub 2026 May 8
Authors: Kaczmarek-Kryszak KA, Dobrzyńska M, Banaszak M, Drzymała-Czyż S
PubMed: 42100836
Submit Comment

Association of mitochondrial genome variants with Alzheimer's disease in a Chinese population.

J Alzheimers Dis. 2026 May 8;:13872877261442231. Epub 2026 May 8
Authors: Hao X, Jiao B, Wang Y, Xu T, Yang Q, Zhu Y, Liu Y, Zhang C, Liang X, Zhou Y, Liao X, Luo S, Tang B, Li J, Xiao X, Shen L
PubMed: 42104711
Submit Comment

Development of AI-assisted 3D-printed degradable hydrogel microneedles for transdermal delivery of progesterone-loaded solid lipid nanoparticles: a novel approach to slowing Alzheimer's disease progression.

Int J Pharm. 2026 May 8;698:126967. Epub 2026 May 8
Authors: Suriyaamporn P, Wongprayoon P, Pannakkong W, Pamornpathomkul B, Ngawhirunpat T, Rojanarata T, Opanasopit P
PubMed: 42107748
Submit Comment

The emerging role of polo-like kinase 2 in Alzheimer's disease.

Exp Neurol. 2026 May 8;403:115806. Epub 2026 May 8
Authors: Martínez-Drudis L, Sheta R, Musiol D, Teixeira M, Oueslati A
PubMed: 42107623
Submit Comment

Aluminum chloride in Alzheimer's disease: A dual focus on molecular mechanisms and rat experimental models.

Exp Neurol. 2026 May 8;403:115814. Epub 2026 May 8
Authors: Khattab NA, El Kadeem A, Goda AE, El-Mahdy NA, El-Shitany N
PubMed: 42107621
Submit Comment

Bayesian modelling of amyloid-beta dynamics and astrocyte influence in Alzheimer's disease.

J Neurosci Methods. 2026 May 8;433:110785. Epub 2026 May 8
Authors: Shaheen H, Melnik R
PubMed: 42107604
Submit Comment

Defective regulated secretion: A trigger for Alzheimer's pathology?

Prog Neurobiol. 2026 May 8;262:102926. Epub 2026 May 8
Authors: Verma B, Singh P, Goberdhan DC, Wilson C
PubMed: 42107515
Submit Comment

The design, synthesis and evaluation of the first carbon-11 positron emission tomography radiotracer for ASK1 imaging.

Bioorg Chem. 2026 May 8;178:109970. Epub 2026 May 8
Authors: Huang Y, Wang Y, Wang Y, Cheng H, Yang H, Wang C, Xu Y
PubMed: 42107260
Submit Comment

Restoring miRNA biogenesis in ALS: Enoxacin enhances DICER activity in a first-in-human trial.

Mol Ther. 2026 May 8; Epub 2026 May 8
Authors: Sivasubramanian R, Sterneckert J
PubMed: 42105767
Submit Comment

Head injuries as a risk factor for amyotrophic lateral sclerosis: A systematic review and meta-analysis.

Clin Neurol Neurosurg. 2026 May 8;267:109466. Epub 2026 May 8
Authors: Toubasi AA, Al-Sayegh TN
PubMed: 42119241
Submit Comment

Bidirectional mediation between microbiota and immune system in Parkinson disease: A two-sample Mendelian randomization study.

Medicine (Baltimore). 2026 May 8;105(19):e48681.
Authors: Qu T, Zhao Q, Fang J, Liang Z
PubMed: 42116350
Submit Comment

The causal relationship between neuroimaging and Parkinson's disease: A two-sample Mendelian randomization study.

Medicine (Baltimore). 2026 May 8;105(19):e48406.
Authors: Wang Y, Zhou S
PubMed: 42116305
Submit Comment

A validated ligand binding assay for the determination of etalanetug, a novel anti-tau therapeutic antibody, in rats and monkeys for nonclinical pharmacokinetic studies.

J Pharm Biomed Anal. 2026 May 8;279:117549. Epub 2026 May 8
Authors: Aoyama M, Noritake Y, Kita K, Mano Y
PubMed: 42127553
Submit Comment

Quantum dot-enhanced tunable FRET nanosensor for Alzheimer's-associated dual miR-34 detection.

Spectrochim Acta A Mol Biomol Spectrosc. 2026 May 8;360:128045. Epub 2026 May 8
Authors: Tu Y, Yang R, Li S, Huang R, Zhang Y, Yang Q, Li J, Zhou L, Zhang W
PubMed: 42127435
Submit Comment

Roles of RNA-Binding Nuclear Proteins in Alzheimer's Disease Pathophysiology.

ACS Pharmacol Transl Sci. 2026 May 8;9(5):1055-1067. Epub 2026 Apr 20
Authors: Kumar S, Upadhyay A
PubMed: 42130721
Submit Comment

Association of dietary copper intake with Alzheimer's disease, brain structure and cognitive function.

J Nutr Health Aging. 2026 May 7;30(7):100868. Epub 2026 May 7
Authors: Wu X, Chen Y, Liu H, Sun Z, Sun P, Liu Y, Shuai P, Yang H, Yang L, Wan Z
PubMed: 42102760
Submit Comment

CAR-A astrocytes for Alzheimer's: Promise and challenge.

Cell Stem Cell. 2026 May 7;33(5):720-721.
Authors: Lee SI, Luo W, Gan L
PubMed: 42102723
Submit Comment

Top five Alzheimer Disease trial eligibility criteria favor men compared to women in a clinic-based cohort.

J Prev Alzheimers Dis. 2026 May 7;13(7):100580. Epub 2026 May 7
Authors: Exalto LG, Syaziyah SS, Fang XT, Prins ND, Sikkes SA, van der Flier WM, Vijverberg EG, Lim YM
PubMed: 42102518
Submit Comment

RNA-based therapeutics for Alzheimer's disease and related tauopathies: challenges and opportunities.

J Prev Alzheimers Dis. 2026 May 7;13(7):100585. Epub 2026 May 7
Authors: Rajbanshi B, Brentari I, Denti MA, Cummings JL, Guruacharya A
PubMed: 42102517
Submit Comment

Beyond amyloid positivity: Biological heterogeneity in the real-world use of lecanemab.

J Prev Alzheimers Dis. 2026 May 7;13(6):100584. Epub 2026 May 7
Authors: Rafii MS
PubMed: 42102503
Submit Comment

SUMOylation in Neural Health and Disease: From Cellular Homeostasis to Neurodegeneration.

DNA Cell Biol. 2026 May 7;:10445498261444640. Epub 2026 May 7
Authors: Oriquat G, Jasim IK, Gajjar TB, Hanumanthayya M, Abdulhameed Ahmad I, Singh G, Maharana L, Bainsal N
PubMed: 42099104
Submit Comment

Methodological considerations on the network meta-analysis of brexpiprazole dosing for agitation in Alzheimer's disease.

J Alzheimers Dis. 2026 May 7;:13872877261449394. Epub 2026 May 7
Authors: Pereira da Silva AM, Haddad Santos D
PubMed: 42099051
Submit Comment

An RNA-Focused DNA-Encoded Library Platform for Discovering Ligands of Pathogenic r(G4C2)exp RNA.

ACS Chem Biol. 2026 May 7; Epub 2026 May 7
Authors: Yang X, Taghavi A, Akahori Y, Pedrini M, Ishii T, Disney MD
PubMed: 42099046
Submit Comment

The mitochondria-synapse axis in Alzheimer's disease: Lost coordination in early stages.

Ageing Res Rev. 2026 May 7;119:103168. Epub 2026 May 7
Authors: Sharma P, Kaur N, Vasal N, Solanki K, Sunkaria A
PubMed: 42106151
Submit Comment

Urolithin A: Potential to enhance autophagic clearance and mitigate neuroinflammation in Alzheimer's disease.

Ageing Res Rev. 2026 May 7;119:103157. Epub 2026 May 7
Authors: Xiang J, Xu J, Zhang Y, Liu X
PubMed: 42106150
Submit Comment

From mild cognitive impairment to normal cognition in Parkinson's disease: The role of brain network architecture.

Neurobiol Dis. 2026 May 7;225:107438. Epub 2026 May 7
Authors: Siciliano M, De Micco R, Pirozzi MA, Goldman JG, Sant'Elia V, Silvestro M, Chiorri C, Cirillo M, Trojano L, Caiazzo G, Esposito F, Tessitore A
PubMed: 42106118
Submit Comment

Multitarget pharmacological effects of Lawsone in mitigating Alzheimer's disease.

Eur J Pharmacol. 2026 May 7;1027:178920. Epub 2026 May 7
Authors: Bashir MA, Ullah I, Batool GA, Khan AU, Shah SU
PubMed: 42105996
Submit Comment

Cobalt and titanium levels in the brain are associated with Alzheimer's disease pathology but not cognition: A study of older adults with and without total joint replacement.

Acta Biomater. 2026 May 7; Epub 2026 May 7
Authors: Pourzal R, Agarwal P, Leurgans SE, McCarthy SM, Hall DJ, McDevitt CA, Ganio K, Ayton S, Bush AI, Grodstein F, James BD, Agrawal S, Hallab NJ, Bennett DA, Schneider JA, Jacobs JJ
PubMed: 42105933
Submit Comment

Spatiotemporal reconfiguration of functional networks by transcranial magnetic stimulation in Alzheimer's disease.

Neuroscience. 2026 May 7;607:123-132. Epub 2026 May 7
Authors: Guo M, Zou Y, Wang T, Wu H, Ji Y, Liu S, Xu G, Wang P
PubMed: 42105904
Submit Comment

A novel insight into the risk of depression and anxiety onset in Parkinson's disease: the implications of GBA1 and LRRK2.

Parkinsonism Relat Disord. 2026 May 7;148:108341. Epub 2026 May 7
Authors: Yang D, Wang J, Huang H, Lin S, Liu Z, Zhang S, Xu J, Zhang B, Cai H, Lin H, Huang S, Chen G
PubMed: 42114177
Submit Comment

Turning as a single and dual task-associations with alzheimer's and vascular pathologies in cognitively healthy older people.

J Gerontol A Biol Sci Med Sci. 2026 May 7; Epub 2026 May 7
Authors: Nilsson MH, Lindh-Rengifo M, Rochester L, Van Westen D, Smith R, Palmqvist S, Stomrud E, Mattsson-Carlgren N, Hansson O
PubMed: 42109046
Submit Comment

Microbiota-Gut-Brain Axis in Neurodegenerative diseases: The Role of Bacterial Amyloids.

Cell Mol Gastroenterol Hepatol. 2026 May 6;:101802. Epub 2026 May 6
Authors: Cissé M, Moullé V, Brossaud R, Oullier T, Neunlist M
PubMed: 42103282
Submit Comment

Mechanism-selective inhibition of α-synuclein aggregation by the chaperone-like BRICHOS domain.

J Biol Chem. 2026 May 6;:113117. Epub 2026 May 6
Authors: Adam L, Molenkamp WH, Nowak JS, Farzadfard A, Gaarthuis K, Kumar R, Nielsen J, Otzen DE, Johansson J, Abelein A
PubMed: 42103226
Submit Comment

The Role of Phospho-ubiquitin in Mitochondrial Health and Diseases.

J Biol Chem. 2026 May 6;:113128. Epub 2026 May 6
Authors: Suresh K, Rainvillee C, Sterner DE, Goldberg MS, Butt TR
PubMed: 42103223
Submit Comment

Targeted liposomal epigallocatechin delivery for Alzheimer's disease: Effect on amyloid β fibrillation and neutralization of free radicals.

Int J Biol Macromol. 2026 May 6;:152399. Epub 2026 May 6
Authors: Andrade S, Ferreira Â, Ramalho MJ, do Carmo Pereira M, Loureiro JA
PubMed: 42103123
Submit Comment

Molecular basis of BACE1 modulation revealed by machine learning, molecular simulations, and experimental validation.

Int J Biol Macromol. 2026 May 6;:152409. Epub 2026 May 6
Authors: Shahab M, Xiao J, Wang J, Huang Z
PubMed: 42103119
Submit Comment

Polyamine and tau: a chemical framework for understanding the hyperphosphorylated tau condensation.

Int J Biol Macromol. 2026 May 6;365:152366. Epub 2026 May 6
Authors: Lee J, Lee K, Kim M, Kim MW, Lim M, Yoo J, Lee SH
PubMed: 42103118
Submit Comment

Multimodal strategies for diagnosis, stratification, and therapeutic monitoring in ALS.

Neurosci Biobehav Rev. 2026 May 6;187:106727. Epub 2026 May 6
Authors: López-Blanch R, Oriol-Caballo M, Estrela JM, Obrador E
PubMed: 42103041
Submit Comment

Neural substrates of apathy in Parkinson's disease: A systematic review of structural and functional neuroimaging studies.

Brain Res Bull. 2026 May 6;240:111922. Epub 2026 May 6
Authors: Marafioti G, Culicetto L, Blundo C, Susinna C, Restuccia G, Di Lorenzo G, Quartarone A, Lo Buono V
PubMed: 42103035
Submit Comment

Lipid dysregulation as a central contributor of neurodegenerative diseases: Emerging therapeutic targets and strategies.

Ageing Res Rev. 2026 May 6;119:103159. Epub 2026 May 6
Authors: Zhang J, Wang C, Li Y, Xiao Z, Cai Z, Qian Y, Shi L, Zhang Q
PubMed: 42102977
Submit Comment

Differential confounds of identification methods in Parkinson's disease models: Neuroinflammatory aggravation by toe-clipping versus sensorimotor disruption by ear-tagging.

J Neurosci Methods. 2026 May 6;433:110790. Epub 2026 May 6
Authors: Jiang X, Wei Y, Wang R
PubMed: 42102894
Submit Comment

Cueing to facilitate naming in MAPT-associated behavioral variant frontotemporal dementia: a preliminary report.

Arch Clin Neuropsychol. 2026 May 6;41(4)
Authors: Barker MS, Mejia A, Zheng EZ, Rizer S, Reid SM, Holmes Iii U, Manoochehri M, Huey ED, Cosentino S
PubMed: 42119153
Submit Comment

[Establishment of reference intervals for plasma p-tau181, Aβ1-42, Aβ1-40, and Aβ1-42/40 ratio and a preliminary study of their correlation with corresponding cerebrospinal fluid reference intervals].

Zhonghua Yu Fang Yi Xue Za Zhi. 2026 May 6;60(5):784-790.
Authors: Zhang QT, Wu WQ, Deng YH, Dong L, Xu YM, Fu XJ, Jiang HQ
PubMed: 42128684
Submit Comment

Sleep quality is associated with default mode and salience network connectivity differently across age and sex.

Neurobiol Aging. 2026 May 6;165:76-91. Epub 2026 May 6
Authors: Tan S, Gourabi S, Cribbet MR, Cundiff JM, McDonough IM
PubMed: 42128467
Submit Comment

Astrocyte reactivity across the AD continuum measured by [18F]SMBT-1 and its relationship with the Aβ burden.

Eur J Nucl Med Mol Imaging. 2026 May 6; Epub 2026 May 6
Authors: Wu Y, Hiraoka K, Mesfin B, Kikuchi A, Watanuki S, Mugikura S, Tomita N, Ishiki A, Furukawa K, Funaki Y, Toyohara J, Kimura Y, Harada R, Furumoto S, Kikuchi A, Watabe H, Kobayashi R, Nihashi T, Kato T, Ishii K, Kawakatsu S, Okamura N, Tashiro M, SMBTSD study project group*
PubMed: 42126566
Submit Comment

Resilience to mid-to-late-life depression as a risk factor for Alzheimer's disease: Physiological factors and the role of neuroimaging.

Neurobiol Aging. 2026 May 6;166:1-13. Epub 2026 May 6
Authors: Chu TD, Hui LM, Khatri N, Jean Chen J
PubMed: 42134046
Submit Comment

Targeting Shared Mechanisms in Atherosclerosis and Alzheimer's Disease.

Curr Alzheimer Res. 2026 May 5; Epub 2026 May 5
Authors: Chaudhari DB, Barve K
PubMed: 42099166
Submit Comment

The Role of Ectopic Fat in Alzheimer's Disease.

Curr Alzheimer Res. 2026 May 5; Epub 2026 May 5
Authors: Yang Y, Huang X, Liu H, Yu C
PubMed: 42099165
Submit Comment

Comparative Efficacy and Safety of Cholinesterase Inhibitors and NMDA Receptor Antagonists in Alzheimer's Disease: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials.

Curr Alzheimer Res. 2026 May 5; Epub 2026 May 5
Authors: Li Y, Li L, Yang Q, Xiong J
PubMed: 42099163
Submit Comment

A Multimodal Framework for Alzheimer's Prevention: Diet, Exercise, Fasting, Sleep, and Gut Microbiota.

Curr Alzheimer Res. 2026 May 5; Epub 2026 May 5
Authors: Kurmi S, Shirodkar S, Parab SB, Doshi G
PubMed: 42099162
Submit Comment

Graphene field-effect transistor based multiplexed sensing platform for simultaneous detection of multiple Alzheimer's disease biomarkers.

RSC Adv. 2026 May 5;16(26):23937-23944. Epub 2026 May 7
Authors: Guo B, Wang J, Lou F, Yuan B, Chen Z, Tang C, Chen W, Yi F, Jiang J, Hu G, Cong C, Lu Y
PubMed: 42111521
Submit Comment

Rapid Detection of Amyloid β1-42 via PAMAM G4 Supported Molecularly Imprinted Sensor.

ACS Omega. 2026 May 5;11(17):25960-25968. Epub 2026 Apr 18
Authors: Ertuğrul Uygun HD, Demir MN
PubMed: 42110765
Submit Comment

Dietary Polyphenols in Brain Aging: Molecular Mechanisms and Implications for Neurodegeneration.

Nutrients. 2026 May 5;18(9)
Authors: Mózes N, Varga JT, Szwajgier D, Kryczyk-Poprawa A, Zábó V, Lehoczki A, Lipécz Á, Csípő T, Fazekas-Pongor V, Major D, Varga P, Matiscsák A, Fekete M
PubMed: 42124071
Submit Comment

Gut Microbiota Dysbiosis in Alzheimer's Disease and Possible Therapeutic Options.

Curr Alzheimer Res. 2026 May 4; Epub 2026 May 4
Authors: Nayak RK, Mohapatra SR, Sahoo SK, Sahu SK, Chowdhury B, Banu Z, Das NR
PubMed: 42099164
Submit Comment

Examining adverse effects in a large clinical trial of rTMS application as a treatment for Alzheimer's disease.

Psychiatry Res. 2026 May 4;362:117212. Epub 2026 May 4
Authors: Uehara MA, Bretecher CA, Teschuk JM, Verot A, Saha C, Fitzgerald PB, Koski L, Millikin C, Moussavi Z
PubMed: 42105452
Submit Comment

Non-Invasive Brain Stimulation in Frontotemporal Dementia: A Systematic Review of Non-Pharmacological Treatment Approaches.

Int J Mol Sci. 2026 May 4;27(9)
Authors: Dognini E, Cerino A, Manenti R, Cotelli M, Borroni B
PubMed: 42123695
Submit Comment

Fructose Intake Is Associated with Brain Metabolic Reprogramming and Exacerbation of Alzheimer-like Alterations in APP/PS1 Mice.

Int J Mol Sci. 2026 May 4;27(9)
Authors: Ormazabal P, Órdenes-Constenla P, Gherardelli C, Bastías-Pérez M, Brito-Valenzuela J, Flores-Opazo M, Inestrosa NC, Cisternas P
PubMed: 42123692
Submit Comment

Correction to: Factors influencing implementation of an Alzheimer's disease blood test among UK old age psychiatrists: mixed-methods study using the theoretical domains framework.

Age Ageing. 2026 May 4;55(5)
Authors:
PubMed: 42132921
Submit Comment

When complexity does not pay: benchmarking deep learning and ensemble methods for biomarker discovery.

Brief Bioinform. 2026 May 3;27(3)
Authors: Njume CM, Petracci I, Bellini S, Goljanek-Whysall K, Quinlan LR, Fiszer A, Borroni B, Ghidoni R, Kumbasar A, Cakmak A
PubMed: 42101927
Submit Comment

Limitations of Stem Cell Therapy for Parkinson's Disease.

Cells. 2026 May 3;15(9)
Authors: Li Z, Peng S, Ouyang J, Liu R
PubMed: 42121940
Submit Comment

Development of tacrine-based multitarget-directed ligands as dual AChE/EGFR inhibitors with neuroprotective activity.

Bioorg Med Chem. 2026 May 2;139:118677. Epub 2026 May 2
Authors: Wei Y, Zhang A, Qiu W, Xiong B, Song Z, Zheng N, Wu Y, Zhang C, Cao Z, Wang X, Xu C, Zhao Q, Wu Y, Liu Z, Chen Y, Sun H
PubMed: 42107267
Submit Comment

Cumulative Incidence in Monogenic Alzheimer's Disease and Frontotemporal Dementia: Gene-Gene Interaction Effect.

Int J Mol Sci. 2026 May 2;27(9)
Authors: Geviti A, Pagano L, Grassi M, Saraceno C, Facconi A, Fostinelli S, Laganà V, Giacomucci G, Cotelli MS, Cantoni V, Ingannato A, Bagnoli S, Bessi V, Longobardi A, Russotto A, Bellini S, Lagrotteria D, Paparazzo E, Binetti G, Montesanto A, Nacmias B, Maletta R, Borroni B, Ghidoni R
PubMed: 42123659
Submit Comment

Exceptional Longevity Modifying Allele APOE2 Promotes DNA Signaling Pathways Resisting Cellular Senescence in Human Neurons.

Aging Cell. 2026 May;25(5):e70494.
Authors: Gerónimo-Olvera C, Scheeler SM, Aguirre CG, Vega-Hormazabal G, Garcia D, Wu L, Murad N, Schneider K, Wilson KA, Markov NT, Song S, Simons J, Gerencser AA, Parlan E, Mooney SD, Verdin E, Campisi J, Tracy TE, Furman D, Melov S, Ellerby LM
PubMed: 42103698
Submit Comment

APOE4 Drives Sex- and Diet-Dependent Effects on AD-Like Pathology, Cognition, and Mitochondrial Function.

FASEB Bioadv. 2026 May;8:e70113. Epub 2026 May 6
Authors: Johnson CN, Lysaker CR, Cao X, Csikos V, Boakye F, Kueck PJ, Franczak E, Geiger PC, Morris JK, Thyfault JP, Wilkins HM
PubMed: 42100472
Submit Comment

Circulating Sphingomyelins Correlate With Plasma T-Tau in Cognitively Unimpaired Older Adults at Risk of Developing Alzheimer's Disease.

J Neurochem. 2026 May;170(5):e70436.
Authors: Sharmin T, Doecke JD, Chatterjee P, Pedrini S, Sohrabi HR, Ashton NJ, Zetterberg H, Garg ML, Blennow K, Martins RN
PubMed: 42104655
Submit Comment

Multiscale Approximations to Understand the Complex Role of Microglia in Alzheimer's Disease.

Eur J Neurosci. 2026 May;63(9):e70536.
Authors: Martínez-Tazo P, Mejias-Ortega M, López-López V, Bhojwani-Cabrera AM, Saxton E, Canals S, Hardingham G, Gutierrez A, Lopez-Atalaya JP, De Santis S
PubMed: 42104633
Submit Comment

Single-cell transcriptomic analysis reveals APOE genotype-dependent sex differences in Alzheimer's disease.

Alzheimers Dement. 2026 May;22(5):e71463.
Authors: Yu G, Thorpe A, Zeng Q, Wang E, Goate A, Cai D, Wang M, Zhang B
PubMed: 42108391
Submit Comment

Rethinking Alzheimer's disease susceptibility and heterogeneity. Comment on Miller et al.

Alzheimers Dement. 2026 May;22(5):e71456.
Authors: Frijo A, Mazzeo S, Filippi M, Salsone M
PubMed: 42108388
Submit Comment

Rational Design and Optimisation of CRISPR-Cas9 Delivery Systems for Targeted Genomic Transformation.

J Gene Med. 2026 May;28(5):e70095.
Authors: Pandya K, Jaisinghani LS, Tripathi A, Kumar D, Saraf SK, Sahoo J, Kumar D
PubMed: 42108387
Submit Comment

Response to rethinking Alzheimer's disease susceptibility and heterogeneity. Comment on Miller et al.

Alzheimers Dement. 2026 May;22(5):e71454.
Authors: Miller ZA, Miller BL, Rabinovici GD, Gorno-Tempini ML
PubMed: 42108385
Submit Comment

Correlation between in vivo 18F-flortaucipir PET and whole-brain postmortem histological tau signals in Alzheimer's disease.

Alzheimers Dement. 2026 May;22(5):e71453.
Authors: Chao Y, Chen Y, Chadwick TA, Harrison TM, Iaccarino L, Heinsen H, Ushizima D, Tosun D, Jagust WJ, Grinberg LT
PubMed: 42108381
Submit Comment

Disentangling amyloid polymorphs in normal aging and Alzheimer's disease using dual-probe spectral imaging.

Neurobiol Aging. 2026 May 1;165:51-59. Epub 2026 May 1
Authors: Stepanchuk AA, Joseph JT, Lashley T, Stys PK
PubMed: 42107415
Submit Comment

The role of quantitative susceptibility mapping in dementia with Lewy Bodies.

Neuroimage Clin. 2026 May 1;50:104000. Epub 2026 May 1
Authors: Capogna E, Venturi G, Motta L, Manners DN, Braghittoni D, Guidi L, Baldelli L, Calandra-Buonaura G, Sambati L, Venneri A, Tonon C, Mitolo M, Lodi R
PubMed: 42105648
Submit Comment

Racial and Ethnic Representation in Dementia Clinical Trials Registered on ClinicalTrials.gov in the United States, United Kingdom, and Canada.

Int J Geriatr Psychiatry. 2026 May;41(5):e70211.
Authors: Kramarczyk D, Ballard C, Corbett A, Da Silva MV, Mcleish KI, Cummings J, Khan Z
PubMed: 42104909
Submit Comment

Correspondence of Basal Forebrain Resting-State Functional Connectivity and Cerebral Glucose Metabolism Alterations With Neurotransmitter Maps in Alzheimer's Disease.

CNS Neurosci Ther. 2026 May;32(5):e70901.
Authors: He Y, Xue H, Bi S, Wang Y, Liu X, Li Y, Chen Z, Rong D, Cui B, Ma J, Yan S, Lu J
PubMed: 42104858
Submit Comment

The Montreal Cognitive Assessment at the Framingham Heart Study: A Re-Examination of the Norms.

Brain Behav. 2026 May;16(5):e71487.
Authors: Muller E, Guan C, Gifford KA, Sunderaraman P, Devine S, Liu Y, Hwang PH, Gurnani AS
PubMed: 42112960
Submit Comment

Corneal Immune Cell Alterations and Tau Pathology in a Mouse Model of Alzheimer's Disease.

Invest Ophthalmol Vis Sci. 2026 May 1;67(5):20.
Authors: Zhang D, Huang D, He J, Shen Y, Dai L, Shi L
PubMed: 42112683
Submit Comment

Commentary on "Peripheral Insulin Resistance and Alzheimer's Disease: Possible Mediators Including Extracellular Vesicles".

Geriatr Gerontol Int. 2026 May;26(5):e70529.
Authors: Zhang P
PubMed: 42108964
Submit Comment

Sphingosine-1-Phosphate as an Immune-Metabolic Biomarker in Neurodegenerative Diseases.

J Clin Neurol. 2026 May;22(3):264-267.
Authors: Kim SH, Jin HK, Bae JS
PubMed: 42108841
Submit Comment

Ginsenoside Rh2 Alleviates Alzheimer Disease Models via Effects on Ferroptosis-Related Neuroinflammation.

J Biochem Mol Toxicol. 2026 May;40(5):e70860.
Authors: Meng Q, Li J, Xu G, Zhang W, Cao R, Cai K
PubMed: 42108759
Submit Comment

Selective reduction of KCNA4 in vulnerable glutamatergic-serotonin neurons of the dorsal raphe nucleus in Alzheimer's disease.

Alzheimers Dement. 2026 May;22(5):e71317.
Authors: Kolling LJ, Balasubramanian N, Ismail S, Feller AJ, Alberhasky JM, Wang R, Jennings L, Hefti M, Marcinkiewcz CA
PubMed: 42117485
Submit Comment

Insulin Receptor Isoform Pattern in Aged Normal and Alzheimer's Human Cortex.

J Neurochem. 2026 May;170(5):e70455.
Authors: Webb-Robinson C, Murray H, Turner CP, Palpagama T, Faull RL, Curtis MA
PubMed: 42117240
Submit Comment

Disentangling treatment status from disease severity in studies of diabetes and Alzheimer's disease biomarkers.

Alzheimers Dement. 2026 May;22(5):e71465.
Authors: Fu Q, Yin X, Xu S
PubMed: 42115835
Submit Comment

Technology access and preferences for remote assessments at Alzheimer's Disease Research Centers.

Alzheimers Dement. 2026 May;22(5):e71467.
Authors: Chan CK, Lane KA, Gao S, Adeoye-Olatunde OA, Shih P, Johnson DK, Saykin AJ, Wang S
PubMed: 42115824
Submit Comment

Minor neuropsychological deficits and stage 2 of Alzheimer's disease.

Alzheimers Dement. 2026 May;22(5):e71458.
Authors: Stark M, Wagner M, Kuhn E, Roeske S, Amthauer H, Bartels C, Boecker H, Brosseron F, Buchert R, Buerger K, Daamen M, Drzezga A, Düzel E, Ersözlü E, Essler M, Ewers M, Fliessbach K, Glanz W, Hellmann-Regen J, Incesoy EI, Janowitz D, Kafali K, Kilimann I, Krause BJ, Kronmüller M, Laske C, Maier F, Maurer A, Michely J, Perneczky R, Peters O, Preis L, Priller J, Rauchmann BS, Reimold M, Rominger A, Schmid M, Schneider A, Sodenkamp S, Spottke A, Spruth EJ, Teipel S, Wiltfang J, Alzheimer´s Disease Neuroimaging Initiative (ADNI), Jessen F, Kleineidam L
PubMed: 42129577
Submit Comment

Mandarin speech-based early detection of SCD: a feature-fusion residual network method.

Alzheimers Dement. 2026 May;22(5):e71460.
Authors: Liu Z, Che C, He G, Wu H, Cai L, Cui L, Liang L
PubMed: 42129462
Submit Comment

Treating dementia with brain amyloid medications.

Can Fam Physician. 2026 May;72(5):330-331.
Authors: Kolber MR, Korownyk CS
PubMed: 42128656
Submit Comment

Metabolomic ageing (MileAge) in mid-life predicts incident vascular, unspecified and all-cause dementia.

Alzheimers Dement. 2026 May;22(5):e71280.
Authors: Mutz J, Gilchrist L, Pain O, Proitsi P, Lewis CM
PubMed: 42126002
Submit Comment

Value-based prices of emerging disease-modifying therapies for Alzheimer's disease in 174 countries: a cost-effectiveness and threshold analysis.

Alzheimers Dement. 2026 May;22(5):e71308.
Authors: Hoang MT, Kahn JG, Saha S, Trépel D
PubMed: 42125995
Submit Comment

Retinal Pathology and Synucleinopathy in the Visual Pathway of α-Synuclein Preformed Fibril Mouse Model of Parkinson's Disease.

Brain Behav. 2026 May;16(5):e71489.
Authors: Zhang Q, Qian XY, Peng T, Hou XO, Ma ZY, Huang J, Hu LF, Luo WF
PubMed: 42133544
Submit Comment

Exposure to Air Pollutants and Lewy Body and Parkinson Disease-Related Dementias.

JAMA Netw Open. 2026 May 1;9(5):e2612601.
Authors: Davydow DS, Pontone GM, Okun MS, Armstrong MJ, Böttger TW, Geels C, Frohn LM, Brandt J, Dreier JW, Christensen J, Pedersen CB, Horsdal HT
PubMed: 42133313
Submit Comment

Glial Fibrillary Acidic Protein and Neurofilament Light Reference Intervals in Healthy Individuals.

JAMA Netw Open. 2026 May 1;9(5):e2612793.
Authors: Rousset RZ, Honey MI, den Braber A, van der Flier WM, Holstege H, Lorenz L, Wessels MH, Killestein J, Huisman M, Kok A, Beekman M, Slagboom PE, Ligthart L, de Geus E, Verberk IM, Vermunt L, Teunissen CE
PubMed: 42133312
Submit Comment

Escin Attenuates Amyloid Beta 1-42-Induced Oxidative Stress, Apoptosis, and Neuroinflammation in Neuron-Like SH-SY5Y Cells.

J Biochem Mol Toxicol. 2026 May;40(5):e70903.
Authors: Akar S, Alvur O, Evyapan G, Ozdem B, Porsuk Doru I
PubMed: 42130250
Submit Comment

Brexpiprazole-Induced Pisa Syndrome in a Patient With Dementia With Lewy Bodies.

Am J Ther. 2026 May-Jun 01;33(3):e271-e273.
Authors: Wang CH, Chen CY, Kuo SC, Yeh YW
PubMed: 42101615
Submit Comment

Proteomic comparison of human neural cell-derived extracellular vesicles and parental cells from Alzheimer's disease and cognitively normal individuals.

Sci China Life Sci. 2026 Apr 30; Epub 2026 Apr 30
Authors: Xin JY, Liu J, Dong HM, Yu HL, Xiao ZS, Hu JN, Jiang Q, Zhu YP, Feng L, Feng Y, Jia YJ, Yuan ZY, Yu ZY, Shi AY, Zeng GH, Wang J, Wang WY, Cheng L, Vella LJ, Li FZ, Masters CL, Wang YJ
PubMed: 42113447
Submit Comment

The Gut Microbiota as a Mediator Linking the MIND Diet to Alzheimer's Disease.

Nutrients. 2026 Apr 30;18(9)
Authors: Ramezani F, Herfeh SS, Burke E
PubMed: 42124045
Submit Comment

Sex-Specific Patterns of Taste Dysfunction, Their Relationships with α-Synuclein Profiling, and Supervised Learning-Based Diagnosis in Parkinson's Disease (PD).

Int J Mol Sci. 2026 Apr 30;27(9)
Authors: Melis M, Angius F, Naciri LC, Sollai G, Deligia S, Fenu G, Mellino P, Pinna B, Crnjar R, Carta AR, Cossu G, Tomassini Barbarossa I
PubMed: 42123627
Submit Comment

The TREM2 R47H variant is associated with liver-plasma-brain axis dyshomeostasis in the 5xFAD mouse model of Alzheimer's disease.

Neurobiol Aging. 2026 Apr 29;165:24-37. Epub 2026 Apr 29
Authors: Faraci G, Goodfriend B, Bishop J, Vu M, Avelar-Barragan J, Dunham SJ, Rothman JA, Whiteson KL, Cheema AK, Milinkeviciute G, Tenner AJ, LaFerla FM, MacGregor GR, Green KN, Mapstone M
PubMed: 42102578
Submit Comment

Natural Products as a Pipeline for Next-Generation Neurodegenerative Drugs: From Single-Target Failure to Multi-Target Opportunity in Alzheimer's and Parkinson's Disease.

Molecules. 2026 Apr 29;31(9)
Authors: Habtemariam S
PubMed: 42123855
Submit Comment

Regulation of Tau Alternative Splicing: A Novel Role for the Ribonucleoprotein RBM20.

Int J Mol Sci. 2026 Apr 29;27(9)
Authors: Corsi A, Valentino A, Bruno MG, Menichetti G, Belpinati F, Pereira MP, Valenti MT, Ruggiero A, Trabetti E, Bombieri C, Romanelli MG
PubMed: 42123583
Submit Comment

Small-Molecule Targeting of the Iron-Responsive Element in the APP mRNA 5'-UTR to Control Amyloid Translation in Alzheimer's Disease.

Int J Mol Sci. 2026 Apr 29;27(9)
Authors: Khan MA, Shaibah HS
PubMed: 42123557
Submit Comment

Extracellular Vesicles in Alzheimer's Disease: Mechanisms, Biomarkers, and Therapeutic Engineering.

Int J Mol Sci. 2026 Apr 29;27(9)
Authors: Wang L, Mao L, Zong X
PubMed: 42123555
Submit Comment

The Role of Antidiabetic Therapies in Mild Cognitive Impairment and Alzheimer's Disease: A Systematic Review of Metformin, Pioglitazone, and GLP-1 Receptor Agonists.

Int J Mol Sci. 2026 Apr 29;27(9)
Authors: Mahoon DA, Hamad O, Butler AE
PubMed: 42123553
Submit Comment

Autophagy-Neuroinflammation Axis in Neurodegenerative Diseases: Mechanisms and Therapeutic Potential.

Cells. 2026 Apr 29;15(9)
Authors: Sun L, Zou Y, Wang L
PubMed: 42121914
Submit Comment

GLP-1 and Parkinson's Disease: A Comprehensive Review of Biology, Mechanisms and Efficacy.

Cells. 2026 Apr 29;15(9)
Authors: Mezabrovschi R, Gegg ME, Schapira AH
PubMed: 42121905
Submit Comment

Macro-event processing in Alzheimer's disease, mild cognitive impairment, and healthy aging: Evidence from a Turkish sample.

Cortex. 2026 Apr 28;200:216-236. Epub 2026 Apr 28
Authors: Karalı FS, Tosun S, Çınar N, Gerwien J
PubMed: 42105724
Submit Comment

Long-Chain Fatty Acids as Drivers of Neuroinflammation in Neurodegeneration: Mechanistic Links to Lipid Peroxidation, Ferroptosis, and Mitochondrial Dysfunction.

Nutrients. 2026 Apr 28;18(9)
Authors: Christodoulou RC, Lorentzen L, Eller D, Vassiliou E
PubMed: 42123994
Submit Comment

Serum Neurofilament Light Chain and GFAP Levels Are Associated with Structural Brain Connectivity in Parkinson's Disease.

Int J Mol Sci. 2026 Apr 28;27(9)
Authors: Bonacci MC, Buonocore J, Calomino C, Bianco MG, Battocchio M, Bontempi P, Daducci A, Cristiani CM, Quattrone A, Caligiuri ME, Quattrone A
PubMed: 42123514
Submit Comment

Genome-Wide CRISPR Screening Identifies Genetic Modulators of Amyloid Precursor Protein Processing.

Int J Mol Sci. 2026 Apr 28;27(9)
Authors: Li Y, Yao Y, Xu Z, Xiong Y, Zhang C, Yu L, Gao H, Fei T
PubMed: 42123509
Submit Comment

Re-Purposing a Rho-Associated Coiled-Coil Kinase (ROCK) Inhibitor for Alzheimer's Disease.

J Clin Med. 2026 Apr 28;15(9)
Authors: Cambi X, Liu Z, Guo K, Xia W
PubMed: 42123112
Submit Comment

Early Müller Glial Activation and Retinal Ganglion Cell Synaptic Dysfunction in APP/PS1 Mice.

Cells. 2026 Apr 28;15(9)
Authors: Zhou Y, Qi G, Zhou H, Gong P, Wang Z, Song X, Tian C, Wu H, Qin S
PubMed: 42121902
Submit Comment

Amyloid Precursor Protein Abnormalities Destabilize Membrane Ferroportin: A Novel Mechanism Underlying Early Brain Pathologies and Memory Impairment in Alzheimer's Disease.

Int J Mol Sci. 2026 Apr 27;27(9)
Authors: Xiao Y, Huang W, Chen L, Huang R, Guo Y, Liu W, Wang X, Wang J, Bao J, Shu X
PubMed: 42123478
Submit Comment

Suppression of Tau Phosphorylation Induces Neurotoxicity, Causing Developmental Defects and Degeneration in C. elegans.

Cells. 2026 Apr 27;15(9)
Authors: Lu MP, Rong Y, Wang J, Yu X, Liu H, Wu Y, Zhang M, Chen Y, Li Y, Yan Y, Liu A, Li Z
PubMed: 42121894
Submit Comment

Distinct Molecular Mechanisms Underlie Modulation of Seeded α-Synuclein Aggregation and Toxicity by Salvianolic Acid B and Dihydromyricetin.

Int J Mol Sci. 2026 Apr 26;27(9)
Authors: Vaikath NN, Achkar IW, Sudhakaran IP, Abdi IY, Ponraj J, El-Agnaf OM
PubMed: 42123431
Submit Comment

Anomic primary progressive aphasia with kanji-predominant dyslexia and dysgraphia.

Cortex. 2026 Apr 25;200:116-123. Epub 2026 Apr 25
Authors: Ota S, Kakinuma K, Katsuse K, Kawakami N, Morita A, Kawamura A, Ogawa N, Iseki C, Kanno S, Matsuda M, Suzuki K
PubMed: 42102541
Submit Comment

Baseline brain volumes predict cognitive decline more robustly than atrophy rates: Evidence for brain reserve.

Cortex. 2026 Apr 24;200:200-215. Epub 2026 Apr 24
Authors: Sambuco N, Scaramuzzi GF, Gasparre D, Cornacchia E, Bonvino A, Antonucci LA, Pergola G, Taurisano P
PubMed: 42105723
Submit Comment

Human and Mouse Alpha-Synuclein Fibrillation: Impact on h-FTAA Binding and Advancing Strain-Specific Biomarkers in PD Animal Models.

Int J Mol Sci. 2026 Apr 24;27(9)
Authors: Swaminathan P, Theologidis V, Gram H, Chatterjee D, Hammarström P, Van Den Berge N, Lindgren M
PubMed: 42123392
Submit Comment

Targeting Neuroinflammation and Oxidative Stress to Slow Neurodegeneration in the Visual System.

J Clin Med. 2026 Apr 24;15(9)
Authors: Shakaki N, Yu M
PubMed: 42122986
Submit Comment

Assessing the Relationship Between Volumetric Changes and Functional Connectivity in Patients with Mild Cognitive Impairment.

J Clin Med. 2026 Apr 23;15(9)
Authors: Machaj W, Podgorski P, Maciaszek J, Szczesniak D, Rymaszewska J, Piotrowski P, Zimny A
PubMed: 42122964
Submit Comment

The Possible Significance of Proteomics in Understanding Molecular Mechanisms of Progressive Supranuclear Palsy, Corticobasal Degeneration, Multiple System Atrophy, and Dementia with Lewy Bodies.

Cells. 2026 Apr 23;15(9)
Authors: Madetko-Alster N, Otto-Ślusarczyk D, Struga M, Alster P
PubMed: 42121860
Submit Comment

Cytoskeletal Imbalance and Axonal Vulnerability in Sporadic PSP-RS: Early Changes in a Human iPSC-Derived Neuronal Model with Altered mTOR Signaling.

Cells. 2026 Apr 23;15(9)
Authors: Covello R, Benedetto GL, Scalise S, Gabriele C, Valente D, Zannino C, Puccio B, Quattrone A, Guzzi PH, Gaspari M, Quattrone A, Cuda G, Parrotta EI
PubMed: 42121856
Submit Comment

Imaging Strategies for Acupuncture Intervention in Alzheimer's Disease Model Mice.

J Vis Exp. 2026 Apr 21;(230)
Authors: Sun R, Wang J, Liu S, Tian H, Wang X, Zhang Y
PubMed: 42113787
Submit Comment

Comment on "profiling mitochondrial DNA indices across whole blood, plasma, and CSF in amyotrophic lateral sclerosis".

J Neurol Sci. 2026 Apr 15;487:125920. Epub 2026 Apr 15
Authors: Shubham, Mathur A
PubMed: 42114311
Submit Comment

Piperine-loaded solid dispersions mitigate amyloid-β-mediated oxidative stress and mitochondrial dysfunction in SH-SY5Y cells: A possible therapeutic strategy for Alzheimer's disease.

J Pharmacol Exp Ther. 2026 Apr 8;393(5):104788. Epub 2026 Apr 8
Authors: Mishra J, Singh C, Bhatti JS
PubMed: 42119549
Submit Comment

Reduced CB1 Cannabinoid Receptor Expression in Alzheimer's Disease and Transgenic Mouse Models.

Aging Med (Milton). 2026 Apr;9(2):168-184. Epub 2026 Apr 24
Authors: von Borcke N, Purwien AV, Steiert A, Hasecke H, Bouter Y
PubMed: 42130756
Submit Comment

Neurodegenerative biomarkers and heart failure: is there a neurodegenerative cardiomyopathy? a systematic review and meta-analysis.

J Geriatr Cardiol. 2026 Mar 28;23(3):152-172.
Authors: Shokravi A, Luo Y, Rabkin SW
PubMed: 42109758
Submit Comment

[Preliminary validation of the Quebec French version of the Memory Binding Test: Comparison with the Rey Auditory Verbal Learning Test in adults aged 55 and older].

Geriatr Psychol Neuropsychiatr Vieil. 2026 Mar 1;24(1):90-101.
Authors: Laflamme E, Rioux É, Breton C, Brizard N, Desjardins S, Gagnon S, Laplante A, Pépin É, Boller B, Vallet GT
PubMed: 42112644
Submit Comment

[Historical approach to late visual hallucinations, from Charles Bonnet to Lewy body disease].

Geriatr Psychol Neuropsychiatr Vieil. 2026 Mar 1;24(1):60-70.
Authors: Albou P
PubMed: 42112641
Submit Comment

[Late-onset frontotemporal degenerations].

Geriatr Psychol Neuropsychiatr Vieil. 2026 Mar 1;24(1):42-58.
Authors: Bertrand F, Gaudiez A, Valadoux AS, Delbeuck X, Deramecourt V, Lebouvier T
PubMed: 42112640
Submit Comment

Biases and consistency of different assay methods for neurological biomarkers using Quanterix single-molecule-array technology: A secondary analysis method comparison study.

NeuroMarkers. 2026 Mar;3(1) Epub 2025 Nov 19
Authors: Go KD, Hutchison J, Wang K, Karikari TK, Mondello S, Diaz-Arrastia R, Puccio A, Stukas S, Cooper JG, Wellington CL
PubMed: 42131469
Submit Comment

Sleep quality metrics combined with virtual reality motion parameters enhance early detection of mild cognitive impairment.

Front Psychiatry. 2026;17:1727576. Epub 2026 Apr 22
Authors: Zhang R, Sun H, Di Y, Cao H, Zhang C, Yao H, Yan H, Ding D, He Q, Wu T
PubMed: 42100782
Submit Comment

Neuroprotective cellular and molecular mechanisms of physical exercise on neurodegenerative diseases.

ADMET DMPK. 2026;14:3058. Epub 2026 Mar 11
Authors: Sahoo SS, Sahu PK, Sa N, Behera A
PubMed: 42100633
Submit Comment

The characteristics and performance of health data domains in supporting dementia identification: A systematic review.

Alzheimers Dement (Amst). 2026;18(2):e70313. Epub 2026 May 6
Authors: Siette J, Kim JW, Zammit JL, Butt A, Sonego S, Ginige JA, Georgiou A, Low LF
PubMed: 42100599
Submit Comment

Social engagement, pleasure, and memory in musical reminiscence workshops for individuals with Alzheimer's disease.

Front Hum Neurosci. 2026;20:1803210. Epub 2026 Apr 22
Authors: Genguelou M, Platel H, Bourgeois C, Gambonnet M, Bayard S
PubMed: 42100568
Submit Comment

Secretory form of viral protease NIa ameliorates amyloid-β pathology and cognitive deficits in a mouse model of Alzheimer's disease.

Front Aging Neurosci. 2026;18:1720518. Epub 2026 Apr 22
Authors: Park EJ, Mun BR, Kim SY, Elangovan M, Kim SB, Choi WS, Park WJ
PubMed: 42100486
Submit Comment

Modulating the default mode network with deep TMS: a proof-of-concept framework with potential relevance to circuits implicated in lack of awareness of cognitive decline.

Front Aging Neurosci. 2026;18:1742759. Epub 2026 Apr 22
Authors: Bellaali Y, Sulcova D, Salatino A, Dricot L, Hanseeuw BJ, Woodard JL, Ivanoiu A
PubMed: 42100484
Submit Comment

Limbic-predominant neuroimaging correlates of plasma p-Tau217 in preclinical and clinical Alzheimer's disease.

Front Aging Neurosci. 2026;18:1748524. Epub 2026 Apr 22
Authors: Patel A, Guiler W, Pepper S, Kemna RE, Kueck PJ, Weidling IW, Mayfield HD, John CS, Mudaranthakam DP, Wilkins HM, Swerdlow RH, Burns JM, Morris JK, Honea RA
PubMed: 42100483
Submit Comment

Integrated transcriptomic profiling combined with in vitro validation reveals the involvement of TMEM140 in the link between periodontitis and brain aging.

Front Aging Neurosci. 2026;18:1761218. Epub 2026 Apr 22
Authors: Zhao H, Wang H, Li W, Su R, Li J, Liu Y, Wang L
PubMed: 42100482
Submit Comment

APOE ε4 as a predictor of cognitive decline and its interaction with hippocampal volume in Alzheimer's disease.

Front Aging Neurosci. 2026;18:1730265. Epub 2026 Apr 22
Authors: Khan FF, Kim JH, Kim JI, Kwon GR
PubMed: 42100481
Submit Comment

Modulation of programmed cell death by botanical drugs in Alzheimer's disease: a review from a traditional Chinese medicine perspective.

Front Pharmacol. 2026;17:1811185. Epub 2026 Apr 22
Authors: Li B, Cui Z, Xu Y, Xu M
PubMed: 42100327
Submit Comment

Correction: Edaravone plays protective effects on LPS-induced microglia by switching M1/M2 phenotypes and regulating NLRP3 inflammasome activation.

Front Pharmacol. 2026;17:1774570. Epub 2026 Apr 22
Authors: Li J, Dai X, Zhou L, Li X, Pan D
PubMed: 42100319
Submit Comment

Clinical outcomes and anti-inflammatory mechanisms of nucleus basalis of Meynert deep brain stimulation in Alzheimer's disease.

Front Neurol. 2026;17:1773910. Epub 2026 Apr 22
Authors: Chen Y, Du T, Lian T, Jiang Y, Yuan T, Li J, Meng F, Yang A, Zhang W, Zhang J
PubMed: 42099973
Submit Comment

The choroid plexus- cerebrospinal fluid axis as a lifespan regulator of neural stem cells and circuit plasticity.

Front Neural Circuits. 2026;20:1818927. Epub 2026 Apr 22
Authors: Rodrigues KS, Yamashita R, Katada S
PubMed: 42099804
Submit Comment

Scoping review of episodic future thinking and delay discounting observed in Alzheimer's disease, depression, and PTSD.

Front Psychol. 2026;17:1764387. Epub 2026 Apr 22
Authors: Dubois JR, Kim E, Pando-Bravo J, Martin LE, Yi R
PubMed: 42099715
Submit Comment

Nerve growth factor responsive elements modulate immune cell inflammation and are dysregulated in an Alzheimer's disease mouse model.

Front Immunol. 2026;17:1722477. Epub 2026 Apr 23
Authors: Gera R, Mocci G, Tambaro S, Vanlandewijck M, Nilsson P, Eriksdotter M, Mitra S
PubMed: 42112371
Submit Comment

Irisin hampers β-amyloid-induced microglial inflammation via the miR-451a/TLR4/NLRP3 axis.

Front Immunol. 2026;17:1761520. Epub 2026 Apr 23
Authors: Mancuso R, Saresella M, Nuzzi R, Agostini S, Marventano I, Hernis A, La Rosa F, Piancone F, Clerici M
PubMed: 42112331
Submit Comment

Investigating white matter functional network connectivity across the Alzheimer's disease spectrum using resting-state fMRI.

Front Neuroimaging. 2026;5:1796824. Epub 2026 Apr 23
Authors: Itkyal VS, LaGrow TJ, Jensen KM, Iraji A, Calhoun VD
PubMed: 42112106
Submit Comment

The modifier matrix: emerging roles of ubiquitin-like proteins in Alzheimer's disease.

Mol Neurodegener Adv. 2026;2(1):18. Epub 2026 May 8
Authors: Yan T, Vaquer J, Springer W, Fiesel FC
PubMed: 42111249
Submit Comment

Glial biomarkers improve classification of cognitive impairment: an explainable artificial intelligence study using CSF biomarkers.

Front Neurol. 2026;17:1787915. Epub 2026 Apr 23
Authors: Türkegün Şengül M, Nemutlu Samur D
PubMed: 42111079
Submit Comment

Efficacy and safety of pharmacological and biological therapies for amyotrophic lateral sclerosis: a network meta-analysis.

Front Neurol. 2026;17:1754716. Epub 2026 Apr 24
Authors: Zhou S, Li X, Jiao Y, Wu J
PubMed: 42111077
Submit Comment

Genetic susceptibility and environmental factors in dementia with Lewy bodies: Converging pathogenic mechanisms.

Front Neurol. 2026;17:1825397. Epub 2026 Apr 24
Authors: Berrios W, Golimstok A, Fernández MC
PubMed: 42111061
Submit Comment

Leveraging Hamiltonian neural flow for robust single-cell multi-omics integration: application to Alzheimer's disease.

Front Genet. 2026;17:1795752. Epub 2026 Apr 24
Authors: Huang Z, Kong W, Wang S
PubMed: 42110915
Submit Comment

The importance of TNF-α signaling: a potential risk factor in neurodegenerative and cardiovascular diseases.

Arch Med Sci. 2026 Jan;22(1):27-44. Epub 2025 Apr 20
Authors: Białecka M, Białecka M, Machoy-Mokrzyńska A, Malinowski D, Rać M
PubMed: 42110595
Submit Comment

Age- and sex-related glymphatic differences and hemispheric asymmetry in healthy adults at 7.0T magnetic resonance imaging.

Psychoradiology. 2026;6:kkag012. Epub 2026 Mar 10
Authors: Yue Y, Tang X, Shen T, Qu B, Lv W, Zhang W, Feng S, Lai HY
PubMed: 42110580
Submit Comment

Efficacy and possible mechanism of Kai-xin-san in animal models of Alzheimer's disease: a systematic review and meta-analysis of preclinical studies.

Front Pharmacol. 2026;17:1806181. Epub 2026 Apr 23
Authors: Wang Y, Wang Q, Xie H, Liu X, Ju Y, Liu X, Sun S
PubMed: 42110549
Submit Comment

Unraveling the anti-neuroinflammatory mechanisms of Cervus cucumis polypeptide injection in Alzheimer's disease: insights from network pharmacology, molecular docking, molecular dynamics simulation, and experimental validation.

Front Aging Neurosci. 2026;18:1797302. Epub 2026 Apr 22
Authors: Fu X, Huang J, Liu Y, Li H, Zhang Y
PubMed: 42109914
Submit Comment

Editorial: Unravelling Aβ toxicity: implications for Alzheimer's cognitive and behavioral deficits.

Front Aging Neurosci. 2026;18:1848776. Epub 2026 Apr 23
Authors: Sharoar MG, Singh N, Hu XY
PubMed: 42109913
Submit Comment

Effects of Baduanjin exercise on working memory in mild cognitive impairment: an fNIRS-based randomized controlled trial.

Front Aging Neurosci. 2026;18:1829586. Epub 2026 Apr 23
Authors: Duan C, Chong Y, Zheng C, Li Z, Ai H, Sun Y, Zhang P, Zou G, Zhang Y, Xia W
PubMed: 42109910
Submit Comment

Noninvasive Terahertz Wave Binocular Stimulation Improves Cognition in Amyloid-β-Related Dementia.

Research (Wash D C). 2026;9:1268. Epub 2026 May 7
Authors: Wu H, Zhang T, Ma J, Yin J, Liu J, Lin H, Yu Y, He Y, Cheng W, Song Z, Chang C
PubMed: 42109888
Submit Comment

Predicting progression of Alzheimer's disease using blood-based multi-omics data.

Bioinform Adv. 2026;6(1):vbag085. Epub 2026 Mar 28
Authors: Vashishath Y, Pijani BA, Goud Baddam N, Saeed F, Bozdag S, Alzheimer’s Disease Neuroimaging Initiative
PubMed: 42109582
Submit Comment

Peripheral oxidative stress related biomarkers in Alzheimer's disease: A systematic review of their implications for diagnosis and disease monitoring.

Alzheimers Dement (Amst). 2026;18:e70354. Epub 2026 May 6
Authors: Osei GN, Kpelle L, Appiah F, Nartey K, Adu AM, Simpong DL, Afrifa J
PubMed: 42109539
Submit Comment

RETRACTION: Aβ-Induced Repressor Element 1-Silencing Transcription Factor (REST) Gene Delivery Suppresses Activation of Microglia-Like BV-2 Cells.

Neural Plast. 2026;2026(1):e9758713.
Authors: Plasticity N
PubMed: 42117260
Submit Comment

RETRACTION: Repressor Element 1 Silencing Transcription Factor (REST) Governs Microglia-Like BV2 Cell Migration via Progranulin (PGRN).

Neural Plast. 2026;2026(1):e9896268.
Authors: Plasticity N
PubMed: 42117219
Submit Comment

Integrative Transcriptomics Identifies Ubiquitination-Related Genes BIRC2, COPS5, and TBK1 as Novel Biomarkers of T-Cell Dysregulation in Amyotrophic Lateral Sclerosis.

J Inflamm Res. 2026;19:585872. Epub 2026 May 5
Authors: Jiang A, Huang Y, Que X, Li C, Lin Z, Huang W
PubMed: 42117108
Submit Comment

Clinical recognition memory testing in older adults should move beyond accuracy alone.

Front Psychol. 2026;17:1764573. Epub 2026 Apr 24
Authors: Kuruvilla MV
PubMed: 42117071
Submit Comment

Methodology for human-induced pluripotent stem cell-derived excitatory and inhibitory neuron coculture with astrocytes for Alzheimer's disease modelling.

Brain Commun. 2026;8(3):fcag135. Epub 2026 May 11
Authors: Li J, Brown LE, Rambarack N, Chan A, Prakash P, Arber C, Wray S, Ali AB
PubMed: 42117065
Submit Comment

Targeting α-Synuclein: Current Strategies and Emerging Therapies for Synucleinopathies.

Protein Pept Lett. 2026;33(1):258-274.
Authors: Bala VC, Singh MK, Kumar A, Tiwari SK, Gupta AK, Chawla R, Kumar S
PubMed: 42116584
Submit Comment

Community-Based Physician Attitudes Related to the Diagnosis and Treatment of Early Alzheimer's Disease in the United States.

Am J Alzheimers Dis Other Demen. 2026;41:15333175261433309. Epub 2026 May 13
Authors: Juday TR, Holub A, Mattke S, Betts KA, Kitchen SA, Liu H, Frech FH, Khachaturian AS
PubMed: 42125963
Submit Comment

Reliability of remote self-administered Web-based digital cognitive measures and comparison to in-person neuropsychological tests: Stricker Learning Span, Symbols Test, and the Mayo Test Drive Screening Battery Composite.

Alzheimers Dement (Amst). 2026;18:e70338. Epub 2026 May 10
Authors: Hughes MA, Frank RD, Taylor RL, Fan WZ, Christianson TJ, Kremers WK, Stricker JL, Machulda MM, Hassenstab J, Mielke MM, Lucas JA, Aduen PA, Day GS, Graff-Radford NR, Jack CR Jr, Graff-Radford J, Petersen RC, Stricker NH
PubMed: 42125541
Submit Comment

Novel insights into early Alzheimer's disease: quantitative gradient recalled echo MRI reveals preatrophic neuronal and myelin injury concurrent with emerging amyloid pathology.

Alzheimers Dement (Amst). 2026;18:e70355. Epub 2026 May 10
Authors: Kothapalli SV, Benzinger TL, Bateman RJ, Li M, Eldeniz C, Morris JC, Yablonskiy DA
PubMed: 42125540
Submit Comment

Characterization and evaluation of the ability of graphene quantum dots to affect α-synuclein aggregation in synucleinopathy models.

Sci Technol Adv Mater. 2026;27(1):2662693. Epub 2026 May 7
Authors: Oz T, Alwani A, Kamińska A, Jachimska B, Timmon Tanaka M, Miki Y, Wakabayashi K, Maziarz K, Kaushik Bhardwaj S, Kaushik A, Figiel M, Chmielarz P, Kujawska M
PubMed: 42125450
Submit Comment

Integrating acoustic, prosodic, and phonological features for automatic Alzheimer's detection.

Front Aging Neurosci. 2026;18:1786269. Epub 2026 Apr 16
Authors: Zakaria Kurdi M
PubMed: 42125251
Submit Comment

Light-based 40 Hz sensory therapy for brain disorders: physiological basis, therapeutic mechanisms, and future prospects.

Front Med (Lausanne). 2026;13:1730333. Epub 2026 Apr 27
Authors: Zhao C, Peng X, Cheng Z, Yue S, Wang Z, Ma L, Li J, Shang M
PubMed: 42125083
Submit Comment

Antioxidants as immunomodulators for Tau and Amyloid-β in Alzheimer's disease.

Adv Protein Chem Struct Biol. 2026;151:303-365. Epub 2025 Nov 7
Authors: Chinnathambi S, Rangappa N, Chandrashekar M
PubMed: 42134891
Submit Comment

Therapeutics immunotargets for Tauopathy.

Adv Protein Chem Struct Biol. 2026;151:267-302. Epub 2025 Nov 4
Authors: Chinnathambi S, Rangappa N
PubMed: 42134889
Submit Comment

Antibodies targeting amyloid-β and Tau oligomers in Alzheimer's disease.

Adv Protein Chem Struct Biol. 2026;151:225-265. Epub 2025 Nov 5
Authors: Chinnathambi S, Rangappa N, Chandrashekar M
PubMed: 42134888
Submit Comment

Induced-pluripotent stem cell-derived immunotherapy for Tau and Alzheimer's disease.

Adv Protein Chem Struct Biol. 2026;151:197-224. Epub 2025 Nov 4
Authors: Chinnathambi S
PubMed: 42134887
Submit Comment

Biosimilars: Antibody and nanobody-based therapeutic approaches towards protein misfolding diseases.

Adv Protein Chem Struct Biol. 2026;151:157-195. Epub 2025 Nov 4
Authors: Chinnathambi S, Rangappa N
PubMed: 42134886
Submit Comment

Treatment of Clinically Diagnosed Alzheimer's Disease by External Counterpulsation A Randomized Clinical Trial.

Am J Alzheimers Dis Other Demen. 2026;41:15333175261451918. Epub 2026 May 14
Authors: Juni JE, Burns JM, Salat DH, Hill D, Tally S, Martin JS, Devous MD, Moriarty PM
PubMed: 42133852
Submit Comment

Retraction: Bioassays guided isolation of berberine from Berberis lycium and its neuroprotective role in aluminium chloride induced rat model of Alzheimer's disease combined with insilico molecular docking.

PLoS One. 2026;21(5):e0349363. Epub 2026 May 14
Authors: PLOS One Editors
PubMed: 42133594
Submit Comment

[Gerstmann-Sträussler-Scheinker disease].

Zh Nevrol Psikhiatr Im S S Korsakova. 2026;126(4):143-149.
Authors: Katunina EA, Putyatin IA, Dolgushin MB, Nadelyaev RV
PubMed: 42133427
Submit Comment

[Choline alfoscerate in the treatment of cognitive impairment].

Zh Nevrol Psikhiatr Im S S Korsakova. 2026;126(4):48-55.
Authors: Shavlovskaya OA
PubMed: 42133414
Submit Comment

[Acteoside: neurobiological activity spectrum, potential in the treatment of age-associated neurodegenerative diseases].

Zh Nevrol Psikhiatr Im S S Korsakova. 2026;126(4):41-47.
Authors: Berezutsky MA, Andronova TA, Belonogova YV, Durnova NA
PubMed: 42133413
Submit Comment

AI-driven telerehabilitation for older adults with mild cognitive impairment: a randomized controlled trial.

Front Neurol. 2026;17:1813694. Epub 2026 Apr 28
Authors: Kim M, Kim DY, Jeong T, Park SW
PubMed: 42131831
Submit Comment

Decoding Pathogenic Mutational Landscapes in Alzheimer's Disease Through Integrated Transcriptomics.

Hum Mutat. 2026;2026:6627566. Epub 2026 May 12
Authors: Ma W, Zhou F, Cai H, Fang L
PubMed: 42131724
Submit Comment

Oxygen extraction fraction is differentially associated with pathological biomarkers in Alzheimer's disease and non-Alzheimer's dementias.

Front Neurosci. 2026;20:1754415. Epub 2026 Apr 28
Authors: Misra A, Wang Y, Taheri MR, Chiang GC, Cho J
PubMed: 42131707
Submit Comment

Glycemic dysregulation and cognitive impairment in aging adults: a cross-sectional study with amyloid biomarker correlation.

Front Aging. 2026;7:1696711. Epub 2026 Apr 28
Authors: Rajalakshmi R, Ramya CM, Naaz R, Madhunapantula SV, Uthaiah CA, Salimath PV
PubMed: 42130812
Submit Comment

Evaluation of conductivity tensor image along the perivascular space in the brains of patients with cognitive impairments.

Front Aging Neurosci. 2026;18:1794175. Epub 2026 Apr 28
Authors: Ahn J, Kim SY, Lee MB, Kwon OI, Rhee HY, Jung YJ, Kim Y, Park S, Ryu CW, Lee J, Jahng GH
PubMed: 42130761
Submit Comment

Functional connectome metrics reveal distinct prognostic subtypes in two Phase 3 gantenerumab trials.

Alzheimers Dement (N Y). 2026;12:e70259. Epub 2026 May 11
Authors: Gobbi S, Silvestri E, Tonietto M, Klein G, van den Heuvel M, Magon S
PubMed: 42130609
Submit Comment

Neuroengineering Frontiers: A Selective Review of Neural Interfaces, Brain-Machine Interactions, and Artificial Intelligence in Neurodegenerative Diseases.

Appl Sci (Basel). 2025 Nov;15(21) Epub 2025 Oct 22
Authors: Usman M, Ashebir S, Okey-Mbata C, Yun Y, Kim S
PubMed: 42112453
Submit Comment

N-Amino Peptide-Graphene Quantum Dot Loaded Small Extracellular Vesicles for Targeted Therapy of Tauopathies.

Adv Nanobiomed Res. 2025 Nov;5(11) Epub 2025 Jul 22
Authors: Zhu R, Kim G, Wang Y, Rajewski BH, Angera IJ, Del Valle JR
PubMed: 42131476
Submit Comment