Alzforum - Papers of the Week: 2-8 Oct 2026

AA and Parkinson's Disease.

Rev Physiol Biochem Pharmacol. 2027;188:187-202.
Authors: Das UN
PubMed: 42834215
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AA in Brain-Memory, Dementia, Depression, Anxiety, Alzheimer's Disease, Affective and Psychiatric Disorders, and Coronary Heart Disease (CHD).

Rev Physiol Biochem Pharmacol. 2027;188:167-186.
Authors: Das UN
PubMed: 42834214
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Short-chain fatty acid-producing commensals: Key modulators of AD neuroinflammation via the microbiota-gut-brain axis.

Curr Res Microb Sci. 2026 Dec;11:100660. Epub 2026 Sep 10
Authors: Ling Z, Huang S, Cheng Y, Liu X, Xu X, Chen Y, Hu P, Wu L, Cai G
PubMed: 42827967
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Comment on: Association Between Calcium Supplement Use and Cognitive Impairment in Ageing Women: A Longitudinal Analysis.

Australas J Ageing. 2026 Dec;45(4):e70238.
Authors: Kucur Yonet C, Yilmaz Kars M, Cicek O, Turgut ZI, Akkar I, Uyar D, Kizilarslanoglu MC
PubMed: 42836637
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Integrating network medicine and foundation models reveals cell-type-specific regulatory alterations in Alzheimer's disease.

NAR Genom Bioinform. 2026 Dec;8(4):lqag116. Epub 2026 Oct 6
Authors: Álvarez-Pérez A, Rodríguez-González A, Baumbach J, Prieto-Santamaría L, Oubounyt M
PubMed: 42840584
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Machine learning-assisted modular triple-signal ratiometric ECL biosensor for multi-Alzheimer's biomarkers detection.

Anal Chim Acta. 2026 Nov 15;1423:346072. Epub 2026 Aug 4
Authors: Yuan W, Jin Q, Wang X, Wang X, Wang X
PubMed: 42838691
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Relationship Between Braak and Clinical Stage in Autopsy-Confirmed Parkinson Disease: A UK Brain Bank Study.

Neurology. 2026 Nov 10;107(9):e218469. Epub 2026 Oct 8
Authors: di Biase L, Pecoraro PM, Bugamelli F, Di Carluccio M, Marsili L, Espay AJ
PubMed: 42848968
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The Braak Paradox: When Parkinson Pathology and Clinical Progression Disconnect.

Neurology. 2026 Nov 10;107(9):e218535. Epub 2026 Oct 8
Authors: Rodríguez-Violante M
PubMed: 42848965
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[Corrigendum] Alteration of the Wnt/GSK3β/β‑catenin signalling pathway by rapamycin ameliorates pathology in an Alzheimer's disease model.

Int J Mol Med. 2026 Nov;58(5) Epub 2026 Oct 2
Authors: Chen J, Long Z, Li Y, Luo M, Luo S, He G
PubMed: 42825350
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Smoking Interacts With APOE ε4 to Influence Dementia: Evidence From the UK Biobank and Validation by Meta-Analysis of Longitudinal Studies.

Biol Psychiatry Glob Open Sci. 2026 Nov;6(6):100800. Epub 2026 Jul 30
Authors: Cong YL, Wang YC, Huang LY, Yang ZL, Tan L, Chu XH, Xu W
PubMed: 42828204
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Quantitative Relationship Between Lumipulse G Measures of pTau217 in Plasma and the Temporal Cortex.

Neurology. 2026 Oct 27;107(8):e218598. Epub 2026 Oct 5
Authors: De Meyer S, Tomé SO, Lahaije B, Vanbrabant J, Lambrechts C, Goossens J, Vanmechelen E, Sleegers K, Von Arnim CA, Tousseyn T, Poesen K, Thal DR, Vandenberghe R
PubMed: 42837647
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Neurofibrillary tangle deposition in primary idiotypic isocortices using flortaucipir PET in histopathologically confirmed Alzheimer's disease.

iScience. 2026 Oct 16;29(10):117530. Epub 2026 Sep 23
Authors: Josephs KA, Weigand SD, Satoh R, Lavrova A, Tapia AL, Graff-Radford J, Machulda MM, Kantarci K, Boeve BF, Petersen RC, Jack CR, Dickson DW, Nguyen AT, Reichard RR, Lowe VJ, Whitwell JL
PubMed: 42830961
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Brain weight across the adult lifespan in great apes.

Proc Natl Acad Sci U S A. 2026 Oct 13;123(41):e2609260123. Epub 2026 Oct 5
Authors: Hrvoj-Mihic B, Stimpson CD, Cree MA, Hillegas ME, Wicinski B, Preuss TM, Hof PR, Raghanti MA, Edler MK, Guevara EE, Hopkins WD, Sherwood CC
PubMed: 42832655
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Vaccine data suggest immunity could mitigate dementia. What's the biology behind these apparent effects?

Proc Natl Acad Sci U S A. 2026 Oct 13;123(41):e2633554123. Epub 2026 Oct 7
Authors: Madhusoodanan J
PubMed: 42842397
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The second assessment of the commutability of candidate reference materials for the harmonization of blood neurofilament light chain measurements.

Clin Chem Lab Med. 2026 Oct 9; Epub 2026 Oct 9
Authors: Andreasson U, Delatour V, Maceski A, Gobom J, Arslan B, Camporesi E, Giangrande C, Auclair G, Sandgren S, Noam Y, Wilson D, Polak M, Norgren N, Mersch G, Dauwe M, Sellner S, Liess A, Sigal GB, Demos C, Blennow K, Zetterberg H, Kuhle J
PubMed: 42848368
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Comparative diagnostic accuracy and clinical utility of the Mini-Addenbrooke's Cognitive Examination, ACE-III, and MMSE for functional staging across the Alzheimer's disease continuum.

Neurol Neurochir Pol. 2026 Oct 8; Epub 2026 Oct 8
Authors: Barczak A, Golan MP, Hintze B
PubMed: 42841817
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Remote Identification of APOE-ε4 Carrier Status in Cognitively Normal Adults via Speech Acoustics: Cross-Sectional Observational Study.

JMIR Form Res. 2026 Oct 8;10:e89830.
Authors: Tavakoli M, Dadgostar M, Green JR, Salat DH, Arnold SE, Connaghan KP, Richburg B, Barnett NV, Tkeshelashvili M, Eshghi M
PubMed: 42849896
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CXCL16-driven neutrophil extracellular traps promote osteoporosis in APP/PS1 mice by disrupting bone remodeling.

Bone. 2026 Oct 8;:118126. Epub 2026 Oct 8
Authors: Chen R, Sun X, Wu T, Tao L, Zhao L, Zhong X, Zhang Q, Yan Q, Lu S, Song Z, Song D, Li L, Niu J, Yang H, Teng Y, Zou J
PubMed: 42849643
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Intermittent Fasting as a Therapeutic Strategy in Alzheimer's Disease: Understanding of Brain-Derived Neurotrophic Factor Modulation.

Physiol Behav. 2026 Oct 8;:115522. Epub 2026 Oct 8
Authors: Shrirame D, Tatode A, Dabhade D, Taksande J, Taksande B, Kakade O, Umekar M
PubMed: 42849557
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Deciphering the heterogeneity of prodromal α-synucleinopathy: linking brain biotyping and gut dysbiosis in isolated REM sleep behaviour disorder.

EBioMedicine. 2026 Oct 8;133:106503. Epub 2026 Oct 8
Authors: Tang S, Yang Y, Wang Y, Gong S, Li N, He Z, Ni J, Wang J, Liu Y, Chan JW, Chu WC, Mok VC, Chen Z, Huang B, Wing YK
PubMed: 42849177
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Immune effects of faecal microbiota transplantation in amyotrophic lateral sclerosis: a pilot multicentre, randomised, masked, sham-controlled, proof-of concept trial.

EBioMedicine. 2026 Oct 8;133:106509. Epub 2026 Oct 8
Authors: Zucchi E, Niccolai E, De Maio F, Cuoghi Costantini R, Quaranta G, Guarnaccia A, Bibbò S, Martinelli I, Gianferrari G, Simonini C, Nannini G, Lulli M, Baldi S, Bartolucci G, Vicini R, Capasso M, Bisogni G, Conte A, Brunori P, Cammarota G, Paganoni S, D'Amico R, Amedei A, Masucci L, Mandrioli J, FETR-ALS Study Group
PubMed: 42849176
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Update on somatic mutations in major neurodegenerative diseases: mutational signatures in neurons and mosaicism.

Curr Opin Genet Dev. 2026 Oct 8;101:102549. Epub 2026 Oct 8
Authors: Freischmidt A, Weishaupt JH
PubMed: 42849148
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Biological amyloids: A scaffold with chemical reactivity.

Curr Opin Struct Biol. 2026 Oct 8;101:103410. Epub 2026 Oct 8
Authors: Buratti FA, Wittung-Stafshede P
PubMed: 42849105
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New studies probe how menopause puts brain at risk.

Science. 2026 Oct 8;394(6820):153-154. Epub 2026 Oct 8
Authors: Smith JE
PubMed: 42848874
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Nicotinamide Riboside for Patients With Early-Stage Parkinson Disease: Research Summary.

JAMA. 2026 Oct 8;:e2618859. Epub 2026 Oct 8
Authors:
PubMed: 42848414
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Nicotinamide Riboside for Patients With Early-Stage Parkinson Disease: The NOPARK Randomized Clinical Trial.

JAMA. 2026 Oct 8; Epub 2026 Oct 8
Authors: Brakedal B, Skeie GO, Derad C, Alstadhaug KB, Anundskås I, Berven H, Biermann M, Bjørnarå KA, Torres Cleuren YN, Dalbro SE, Eidelberg D, Foldnes K, Fortes G, Haugarvoll K, Herlofson K, Hustad E, HogenEsch RI, Johanson GA, Johnsen SH, Kunszt K, Kverneng S, Labusau A, Lie IH, Lilleng H, Lundervold K, Lundqvist C, Ma Y, McCann A, Njølstad TH, Pihlstrøm L, Riemer F, Rognerud AK, Sheard E, Simonsen AM, Storm E, Svensen M, Toker L, Tunold JA, Dölle C, Friede T, Tzoulis C
PubMed: 42848371
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Pre-diagnostic ALSFRS-R slope provides limited incremental information about the variability in subsequent functional decline in amyotrophic lateral sclerosis: a population-based study.

J Neurol. 2026 Oct 8;273(10)
Authors: Vasta R, Calvo A, Moglia C, Canosa A, Manera U, Gianferrari G, Zucchi E, Martinelli I, Mora G, Cabras S, Palumbo F, Matteoni E, Maccabeo A, Pellegrino G, Minerva E, Pascariu D, Callegaro S, D'Ovidio F, Mazzini L, De Marchi F, Mandrioli J, Chiò A
PubMed: 42848219
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Plant-derived phytochemicals for Alzheimer's disease: mechanisms of action, experimental evidence, and therapeutic perspectives.

J Nat Med. 2026 Oct 8; Epub 2026 Oct 8
Authors: Nimbalkar J, Shinde R
PubMed: 42848122
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Contrasting clinical trajectories in two ALS patients with rare FUS variants: implications for variant interpretation, penetrance, and trial readiness.

Neurogenetics. 2026 Oct 8;27(1)
Authors: Gaete PV, Preciado MP, Díaz JJ
PubMed: 42848030
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Disrupted synaptic vacuolar H+-ATPase renders synaptic vulnerability to Alzheimer's disease.

JCI Insight. 2026 Oct 8;11(19) Epub 2026 Oct 8
Authors: Chen Y, Emam KA, Yue S, Tian J, Wang T, Park A, Mishra S, Deep G, Wang ZJ, Du H, Guo L
PubMed: 42847994
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Cerebrospinal fluid surfactant protein-G in neurodegenerative dementia: A comparative study with idiopathic normal-pressure hydrocephalus.

J Alzheimers Dis. 2026 Oct 8;:13872877261487596. Epub 2026 Oct 8
Authors: Cattaldo S, Scarpina F, Prina E, Piterà P, Milesi A, Sabattini E, Bigoni M, Azzaro C, Pradotto LG, Mauro A, Priano L
PubMed: 42847983
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Limitations of current neuroprotective therapies in dementia with Lewy bodies.

Expert Rev Clin Pharmacol. 2026 Oct 8; Epub 2026 Oct 8
Authors: O'shea DM, Disla S, Gosling AE, Valdelamar GA, Ioana Tolea M, Galvin JE
PubMed: 42847732
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White matter hyperintensity burden in amyotrophic lateral sclerosis: motor and survival correlates.

Brain. 2026 Oct 8; Epub 2026 Oct 8
Authors: De Lorenzo A, Maranzano A, Cocuzza A, Gentile F, Passaretti M, Colombo E, Torre S, Aiello EN, Calcagno N, Gendarini C, Olivero M, Scheveger F, Patisso V, Spagliardi J, Di Maio A, Pierro S, Treddenti M, Gagliardi D, Comi GP, Corti S, Pereira JB, Agosti P, Peyvandi F, Messina S, Doretti A, Poletti B, Morelli C, Silani V, Cinnante CM, Verde F, Ticozzi N
PubMed: 42847641
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Considerations for therapeutic targets for clinical trials in biomarker-characterized prodromal Parkinson's disease populations.

J Parkinsons Dis. 2026 Oct 8;:1877718X261493297. Epub 2026 Oct 8
Authors: Schneider RB, Skibinski G, Fiske B, Kopil CM, Merchant K, Simuni T
PubMed: 42847638
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Subjective Cognitive Concerns and Cognitive Trajectories in Parkinson's Disease: Biomarker Impact.

Ann Clin Transl Neurol. 2026 Oct 8; Epub 2026 Oct 8
Authors: Lopez FV, Erani F, Bangen KJ, Coughlin DG, Galasko D, Thomas KR
PubMed: 42847555
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Profiling peripheral immune cells in Parkinson's disease: A scoping review.

J Parkinsons Dis. 2026 Oct 8;:1877718X261479505. Epub 2026 Oct 8
Authors: Recinto SJ, Jernigan Posey JE, Lefter N, Vitic Z, Overgaard MØ, Liu L, Howden AJ, Eyer K, Romero-Ramos M, Tansey MG, Stratton JA
PubMed: 42847443
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A randomized pilot trial of non-flickering 40 Hz light stimulation: EEG activity and cognitive outcomes in cognitively normal older adults.

J Alzheimers Dis. 2026 Oct 8;:13872877261494219. Epub 2026 Oct 8
Authors: Cheng CH, Lu H
PubMed: 42847333
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Greater amyloid burden in cognitive networks in preclinical Alzheimer's disease.

J Alzheimers Dis. 2026 Oct 8;:13872877261493984. Epub 2026 Oct 8
Authors: Nolin SA, Aghamoosa S, Rieter WJ, Jones A, Nietert PJ, Benitez A
PubMed: 42847330
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Melatonin as a potential biomarker for subclinical epileptiform activity in Alzheimer's disease: An exploratory study.

J Alzheimers Dis. 2026 Oct 8;:13872877261490539. Epub 2026 Oct 8
Authors: Nous A, Seynaeve L, Feys O, Wens V, De Tiège X, Van Mierlo P, Baroumand AG, Mangelschots S, Michiels V, De Witte S, Wittens MM, Bjerke M, Ceyssens S, Gordijn M, De Weerdt S, Van Eekchaut A, Nagels G, Smolders I, Engelborghs S
PubMed: 42847306
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Impact of dementia severity on efficacy of brexpiprazole for agitation in Alzheimer's dementia: A post hoc analysis of a randomized, double-blind, placebo-controlled study in Japan.

J Alzheimers Dis. 2026 Oct 8;:13872877261493010. Epub 2026 Oct 8
Authors: Nakamura Y, Seiyama Y, Shimizu K, Shibasaki Y, Toda R, Nakamichi N, Adachi J, Hirota N, Nakai M, Takahashi K
PubMed: 42847294
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Neuroanatomical correlates of the CDT-14: A voxel-based morphometry study exploring incremental information beyond conventional clock drawing scores.

J Alzheimers Dis. 2026 Oct 8;:13872877261493066. Epub 2026 Oct 8
Authors: Sawada Y, Satoh T, Saba H, Kato Y, Kuwada T, Shima S, Murakami K, Sasaki M, Abe Y, Harano K
PubMed: 42847293
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PET-based evaluation of short-term amyloid-β clearance and predictive factors in real-world Alzheimer's disease patients treated with lecanemab.

J Alzheimers Dis. 2026 Oct 8;:13872877261493063. Epub 2026 Oct 8
Authors: Qiao Z, Zhao X, Wang G, Li S, Lian T, Ai L
PubMed: 42847291
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Study on the global and national burden of Alzheimer's disease attributable to dietary fatty acids from 1990 to 2018: A combined analysis based on the global burden of disease and global dietary database.

J Alzheimers Dis. 2026 Oct 8;:13872877261492342. Epub 2026 Oct 8
Authors: Zhu L, Liu J, Chen J, Yang L, Li S, Yang X
PubMed: 42847287
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Harmonizing ALS research data across multimodal data sets using the OMOP Common Data Model.

Amyotroph Lateral Scler Frontotemporal Degener. 2026 Oct 8;:1-3. Epub 2026 Oct 8
Authors: Jernigan B, Walters HL, Corey D, Garcia A, Premasiri A, Roddy WT, Shearer D, Thompson TG, Tucker J, Vieira F, Boyce D
PubMed: 42847178
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Aqueous extracts of Phyllanthus amarus leaf mitigate cognitive impairments by enhancing neurotransmitter regulation and antioxidant defense mechanisms.

Neurodegener Dis Manag. 2026 Oct 8;:1-12. Epub 2026 Oct 8
Authors: Adedayo BC, Oyeleye IS, Oyelami OS, Aro OP, Ojo OR, Oboh G
PubMed: 42847130
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Building Scalable Recruitment Models for Precision Medicine in Parkinson's Disease: Insights from GBA1 Trials.

Mov Disord. 2026 Oct 8; Epub 2026 Oct 8
Authors: Corvol JC, Tesson C, Liot S, Carvalho S, Castelnovo G, Damier P, Defebvre L, Giordana C, Houeto JL, Marques A, Meissner WG, Remy P, Thobois S, Fabbri M, Rascol O, NS‐PARK cohort
PubMed: 42845097
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RVG29-functionalized nanocarriers for brain-targeted therapy of neurodegenerative diseases: mechanisms, therapeutic advances, and translational perspectives.

Naunyn Schmiedebergs Arch Pharmacol. 2026 Oct 8; Epub 2026 Oct 8
Authors: Gandhi SM, Patel S, Haswani NG, Wahab S, Sabah ZU, Kapoor DU
PubMed: 42844308
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Cognitive and linguistic impairments in adults with Down syndrome and Alzheimer's disease: a systematic review.

Aging Ment Health. 2026 Oct 7;:1-9. Epub 2026 Oct 7
Authors: Gaete-Espina M, Becerra-Quinteros A, Hermosilla-Navea C, Orellana-Rubilar J, López-Véliz X, Flores-Carrasco S
PubMed: 42844026
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Microbiota-Brain Interactions in Dementia: Role of Diet in Neuroinflammation.

Ann Geriatr Med Res. 2026 Oct 7; Epub 2026 Oct 7
Authors: Chakraborty A, Desai N, Kaxon-Rupp A, Lamichhane Khadka R, Mohaddes G
PubMed: 42843795
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Differential associations of PM2.5 and particulate manganese with blood-based amyloid and tau biomarkers in cognitively unimpaired older adults.

Environ Pollut. 2026 Oct 7;:129304. Epub 2026 Oct 7
Authors: Yeom J, Park H, Jang H, Noh Y, Koh SB, Lee JI, Kim HH, Kim SY, Kim C, Cho J
PubMed: 42843548
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ER-Nε-lysine acetylation machinery in neurological disorders: A context-dependent regulator of proteostasis.

Curr Opin Chem Biol. 2026 Oct 7;95:102786. Epub 2026 Oct 7
Authors: Di Martino E, De Vos R, Koenig Gimeno S, Ricciardi F, Luchicchi A, Orefice NS
PubMed: 42843274
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Baseline CSF and plasma glucocerebrosidase activity predict longitudinal cognitive decline in Parkinson's disease: A PPMI longitudinal cohort study.

J Clin Neurosci. 2026 Oct 7;154:112325. Epub 2026 Oct 7
Authors: Kazemi E
PubMed: 42843141
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From pathogenesis to non-medical therapy: A review of exploring sensory and multi-sensory stimulation as a non-invasive treatment approach for Alzheimer's disease.

Neurosci Biobehav Rev. 2026 Oct 7;191:107004. Epub 2026 Oct 7
Authors: Zhu Y, Jafari Z, Kolb BE, Mohajerani MH
PubMed: 42843100
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Alterations in diacylglycerol kinase θ define early pathological features of Alzheimer's disease in a mouse model.

J Alzheimers Dis. 2026 Oct 7;:13872877261490813. Epub 2026 Oct 7
Authors: Lanza M, Basilotta R, Scuderi SA, Giovani P, Caccamo A, Casili G, Oddo S, Esposito E
PubMed: 42842740
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Human microglia clear intraneuronal α-synuclein aggregates by GPNMB-mediated trogocytosis.

Sci Transl Med. 2026 Oct 7;18(870):eadz9258. Epub 2026 Oct 7
Authors: Chueh HJ, Katsikoudi A, Aragón-González A, Lam CL, Tamon L, Jainarayanan A, Agarwal D, Cowley SA, Sims D, Tofaris GK
PubMed: 42842725
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Advances in Extracellular Vesicle-Based Innovative Drugs Targeting Alzheimer's Disease.

Mol Neurobiol. 2026 Oct 7;63(1)
Authors: Liu S, Lu J, Liu J, Liu H, Liu Z, Yang D, Liang X, Xu J
PubMed: 42842141
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An integrated resource for systems-level analysis of aging hallmarks and associated genes.

Biogerontology. 2026 Oct 7;27(5)
Authors: Tiwari R, Balaji M, Chivukula N, Sil P, Samal A
PubMed: 42842105
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From a prion seed to a tree of discoveries: Byron Caughey's RT-QuIC legacy in protein misfolding research.

Acta Neuropathol. 2026 Oct 7;152(1)
Authors: Groveman BR, Vascellari S, Bongianni M, Hughson AG, Zanusso G, Orrú CD
PubMed: 42842018
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Amyloid-β plaque diversity across brain regions in Alzheimer's disease and its relation to major clinicopathological traits.

Acta Neuropathol. 2026 Oct 7;152(1)
Authors: Neubauer A, Feyen P, Pekrun S, Roeber S, Ruf V, Strübing FL, Herms J
PubMed: 42841982
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Depression and anxiety in vascular dementia: an update.

J Neural Transm (Vienna). 2026 Oct 7; Epub 2026 Oct 7
Authors: Jellinger KA
PubMed: 42841964
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N-terminal proVGF modifications related to Amyotrophic Lateral Sclerosis.

Amyotroph Lateral Scler Frontotemporal Degener. 2026 Oct 7;:1-9. Epub 2026 Oct 7
Authors: Anjum A, Manai AL, Noli B, Borghero G, Mascia MM, Meloni M, Kais H, Figorilli M, Puligheddu M, Cocco C
PubMed: 42841866
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Rifaximin ameliorates memory impairment and Alzheimer's pathological changes in APP/PS1 mice associated with changes in the gut microbiome-bile acids-serum metabolites networks.

Br J Pharmacol. 2026 Oct 7; Epub 2026 Oct 7
Authors: Wu D, Nie MT, Lin J, Liu Y, Wang Y, Chu M, Zheng L, Zhao J
PubMed: 42841516
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Nerve growth factor metabolic dysfunction in Down's syndrome brains.

Brain. 2026 Oct 7; Epub 2026 Oct 7
Authors: Iulita MF, Do Carmo S, Ower AK, Fortress AM, Flores Aguilar L, Hanna M, Wisniewski T, Granholm AC, Buhusi M, Busciglio J, Cuello AC
PubMed: 42841319
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Clinical and genetic characterization of FUS-associated ALS in a tertiary cohort.

Amyotroph Lateral Scler Frontotemporal Degener. 2026 Oct 7;:1-4. Epub 2026 Oct 7
Authors: Bettoni V, Nath SR, Johnson S, Oskarsson B, Bojko A, Salmaninejad A, Tan-Arroyo J, Cousin MA, Staff NP
PubMed: 42839902
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Mitochondrial DNA damage elicits PINK1 upregulation in pontine cholinergic neurons in Parkinson's disease.

Brain. 2026 Oct 7; Epub 2026 Oct 7
Authors: Lu H, Pyle A, Steyn JS, Lawless C, Hussain R, Falkenberg M, Elson JL, Pienaar IS
PubMed: 42839534
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Accelerated brain aging as a transdiagnostic biomarker: A lifespan MRI brain age study across seven disorders.

Psychol Med. 2026 Oct 7;56:e321.
Authors: Gupta Y, de la Cruz F, Geisler M, Rieger K, Schumann A, Bär KJ
PubMed: 42839301
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Cortical thickness signature of early-onset Alzheimer's disease across clinical stages and A/T1 biomarker profiles.

J Neurol. 2026 Oct 7;273(10)
Authors: Zilioli A, Mohanty R, Rosenberg A, Matton A, Granberg T, Hagman G, Spallazzi M, Kivipelto M, Westman E
PubMed: 42839194
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Alzheimer's disease and olfactory dysfunction: A 20-year systematic bibliometric and genomic analysis.

J Alzheimers Dis. 2026 Oct 7;:13872877261486344. Epub 2026 Oct 7
Authors: Yang G, Meng C, Zhu D
PubMed: 42844735
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High-resolution NMR spectroscopy of proteins in intact mitochondria.

Nat Chem Biol. 2026 Oct 7; Epub 2026 Oct 7
Authors: Zhang Z, Zhang C, Xu G, Du R, Yu J, Liu X, Chai Z, Wu Q, Jiang L, Liu M, Li C
PubMed: 42844454
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Astrocytes regulate axonal mitochondrial transport deficits in C9ORF72 amyotrophic lateral sclerosis motor neurons.

Nat Neurosci. 2026 Oct 7; Epub 2026 Oct 7
Authors: Stavrou M, Heffernan ÁB, Carter RN, Dando O, Jiwaji Z, Burr K, Nanda J, Villarroel-Campos D, Masoud Abdelhafid A, Cholewa-Waclaw J, Soong D, Story D, Schiavo G, Hardingham GE, Chandran S, Selvaraj BT
PubMed: 42844425
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Peripheral dendritic cell priming of CD8+ T cells drives tau-related neurodegeneration.

Nat Aging. 2026 Oct 7; Epub 2026 Oct 7
Authors: Aman Y
PubMed: 42844387
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Memantine in Korean Alzheimer's disease: A prospective real-world REMIND study.

Int Psychogeriatr. 2026 Oct 6;:100298. Epub 2026 Oct 6
Authors: Na S, Kim HS, Kim GH, Kwon OD, Shim YS, Lee CN, Rhee HY, Choi H, Hong YJ, Lee J, Moon SY, Park KH
PubMed: 42838860
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Erratum to "The PINK1-VCP-p47 pathway protects against tau-induced dendritic shrinkage in cortical neurons through interaction with STIP1" [Neurobiol. Dis. 229 (2026) 107592].

Neurobiol Dis. 2026 Oct 6;:107616. Epub 2026 Oct 6
Authors: Banerjee S, Wang KZ, DeChellis-Marks MR, Ross MR, Oury NH, Chu CT
PubMed: 42838796
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"Structural and Metabolic Reprogramming by Docosahexaenoic Acid in Neuronal Cell Models of Alzheimer's Disease".

Biochimie. 2026 Oct 6; Epub 2026 Oct 6
Authors: Rana A, Mélanie P, Van Amanda L, Nathalie BH
PubMed: 42838381
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Alzheimer's disease as progressive failure of dynamic memory architecture and conscious integration.

Ageing Res Rev. 2026 Oct 6;123:103397. Epub 2026 Oct 6
Authors: Parihar MS, Goplani V, Sharma G
PubMed: 42838291
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A silent RAGE: The inflammatory pathway to dementia in Parkinson's disease.

Ageing Res Rev. 2026 Oct 6;123:103392. Epub 2026 Oct 6
Authors: Peixoto DO, Gasparotto J, Ojo OR, Aro OP, Godswill US, de Abreu LF, Lopes LC, Moreira JC, Gelain DP
PubMed: 42838289
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Deep Learning-based Synthesis of Amyloid PET Images from Structural MRI in Alzheimer's Disease.

Mol Imaging Biol. 2026 Oct 6; Epub 2026 Oct 6
Authors: Zhang Z, Wu J, Wang P, Chai K, Jiang S, Onyike CU, Smith GS, Zhou J, Alzheimer’s Disease Neuroimaging Initiative
PubMed: 42837090
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A Live-Cell Imaging System for the Identification of Pro- and Anti-Aggregatory α-Synuclein Modulators.

Mol Neurobiol. 2026 Oct 6;63(1)
Authors: Tal T, Almog Y, Cohen OI, Radomir L, Bar-On D, Fishbein I, Meshorer E
PubMed: 42837064
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Glymphatic function in humans: indicators, modulators, and measurement strategies.

Neurol Sci. 2026 Oct 6;47(10)
Authors: Nyan TH, Park H, Baek HJ, Park E, Cho J
PubMed: 42837021
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SOD1 co-pathologies in the brain: insights from neuropathological evidence and implications.

Acta Neuropathol. 2026 Oct 6;152(1)
Authors: de Azevedo EM, Bernardo VS, Lima MM, Eleutherio EC, Outeiro TF
PubMed: 42837018
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TRICALS risk score augments but cannot replace neurofilament as a prognostic biomarker in ALS.

J Neurol. 2026 Oct 6;273(10)
Authors: Al Khleifat A, Malaspina A, Kirby J, Tree T, Shaw PJ, Leigh PN, Al-Chalabi A
PubMed: 42836993
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Does genetic testing remain relevant in advanced Parkinson's disease?

J Neural Transm (Vienna). 2026 Oct 6; Epub 2026 Oct 6
Authors: Westenberger A, Endaya NJ, Brüggemann N
PubMed: 42836964
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Genetic findings in a Turkish clinical cohort with hereditary Parkinson's disease.

Neurogenetics. 2026 Oct 6;27(1)
Authors: Ozata Aksoy D, Tunca Y, Sonkaya AR, Torun D, Korucu O
PubMed: 42836888
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Multiscale Transcriptomic Network Models of Parkinson's Disease at the Single Cell Level.

Gigascience. 2026 Oct 6; Epub 2026 Oct 6
Authors: Chu L, Yu G, Zhou X, Wang M, Yue Z, Zhang B
PubMed: 42836551
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Intranasal Artesunate Ameliorates Hippocampal LFP Abnormalities and Cellular Apoptosis in APP/PS1 Mice via a Mechanism Involving GHRH/PI3K/AKT Signaling.

Mol Neurobiol. 2026 Oct 6;63(1)
Authors: Jin Y, Gong X, Shen L, Zhang M, Song K, Yao H
PubMed: 42834252
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Design, synthesis, and biological evaluation of naphthalimide derivatives as dual monoamine oxidase-B and amyloid-β aggregation inhibitors for Alzheimer's disease.

RSC Adv. 2026 Oct 6; Epub 2026 Oct 6
Authors: Praveen R, Gadaleta A, Spada G, Miniero DV, Reza A, Chaudhari TY, Rahman A, Catto M, Hoda N
PubMed: 42840889
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Neuropsychiatric and Cognitive Symptom Evolution over the First Decade of Biomarker-Positive, Sporadic Parkinson's Disease.

Mov Disord. 2026 Oct 6; Epub 2026 Oct 6
Authors: Schoen I, Wang J, Xie SX, Caspell-Garcia C, Mamikonyan E, Stark M, Dahodwala N, Siderowf AD, Dobkin R, York MK, Weintraub D
PubMed: 42839627
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Correction: Semantic fluency predicts survival of memory clinic patients.

Alzheimers Res Ther. 2026 Oct 6;18(1)
Authors: Frings L, Brumberg J, Meyer PT
PubMed: 42839289
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Predictors of Seizure Occurrence After Mild Cognitive Impairment and Alzheimer's Disease in Older Adults in the Veterans Affairs Healthcare System: A Retrospective Cohort Study.

Neurol Ther. 2026 Oct 6; Epub 2026 Oct 6
Authors: Abdennadher M, Wang Y, Reisman J, Hu W, Morin P, Berlowitz DR, Mittler B, Tahami Monfared AA, Zhang Q, Xia W
PubMed: 42839211
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Periodontal disease and risk of dementia: a systematic review and meta-analysis.

Evid Based Dent. 2026 Oct 6; Epub 2026 Oct 6
Authors: D'Souza V, Bhagirath A, Verma I, Johnson J, Wang Y, Shenoy R
PubMed: 42839061
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Association among white matter lesions, rsEEG rhythms, amyloid tau markers, and cognitive status in mild cognitive impairment patients.

Clin Neurophysiol. 2026 Oct 6;193:2112432. Epub 2026 Oct 6
Authors: Del Percio C, Lizio R, Noce G, Carpi M, Lopez S, Carducci F, De Bartolo M, Afragola AP, Soricelli A, Salvatore M, Giubilei F, Güntekin B, Yener G, Massa F, Arnaldi D, Famà F, Pardini M, Ferri R, Lanuzza B, Stocchi F, Vacca L, Coletti C, Infarinato F, Marziali S, Marizzoni M, Taylor JP, Hanoğlu L, Yırıkoğulları H, Frisoni GB, Cuoco S, Cappiello A, Barone P, Bonanni L, Biundo R, Cauzzo S, Fiorenzato E, Antonini A, De Pandis MF, D'Antonio F, Bruno G, Babiloni C
PubMed: 42849193
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Retraction notice to "A computational approach to identify blood cell-expressed Parkinson's disease biomarkers that are coordinately expressed in brain tissue" [Computers in Biology and Medicine 113 (2019) 103385].

Comput Biol Med. 2026 Oct 5;:111969. Epub 2026 Oct 5
Authors: Moni MA, Rana HK, Islam MB, Ahmed MB, Xu H, Hasan MA, Lei Y, Quinn JM
PubMed: 42830240
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Corrigendum to "Nano-honokiol ameliorates the cognitive deficits in TgCRND8 mice of Alzheimer's disease via inhibiting neuropathology and modulating gut microbiota" [J. Adv. Res. 35 (2021) 231-243].

J Adv Res. 2026 Oct 5; Epub 2026 Oct 5
Authors: Qu C, Li QP, Su ZR, Ip SP, Yuan QJ, Xie YL, Xu QQ, Yang W, Huang YF, Xian YF, Lin ZX
PubMed: 42833976
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TDP-43 and ALS - what's wrong with my membranes?

Neurobiol Dis. 2026 Oct 5;230:107630. Epub 2026 Oct 5
Authors: Dahlhaus R, Yalcin I, Tischer J, Braun RJ
PubMed: 42833594
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Plasma PINK1/Parkin ratio and ATF5 as potential biomarkers associated with dyskinesia in Parkinson's disease.

Neurobiol Dis. 2026 Oct 5;230:107638. Epub 2026 Oct 5
Authors: Qian S, Xiang W, Chen K, Du Y, Xu B, Duan Q, Xiong X, Hou J, Jiang T, Xie D, Qian J, Xie C, Li J
PubMed: 42833593
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Mechanomarker-informed identification of Alzheimer's disease based on lateral ventricular deformation.

Brain Res Bull. 2026 Oct 5;:112146. Epub 2026 Oct 5
Authors: Cunniff L, Weickenmeier J
PubMed: 42833370
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Phase-locked closed-loop ultrasound stimulation of hippocampal slow gamma modulates CA3-CA1 coherence and improves spatial memory in APP/PS1 mice.

J Neural Eng. 2026 Oct 5; Epub 2026 Oct 5
Authors: Xie Z, Ji H, Karadas M, Zhang Y, Yuan Y
PubMed: 42833256
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Long-term exposure to ultrafine particles and mortality from neurodegenerative diseases: a population-based cohort study.

Epidemiology. 2026 Oct 5; Epub 2026 Oct 5
Authors: Batisse E, Lloyd M, Renoux C, Ganji A, Xu J, Hatzopoulou M, Weichenthal S, Baumgartner J
PubMed: 42832702
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Earlier Disclosure of Blood-Based Biomarkers, Diagnostic Certainty, and Clinical Management: A Randomized Clinical Trial.

JAMA Neurol. 2026 Oct 5; Epub 2026 Oct 5
Authors: Estragués-Gázquez I, Contador J, Martínez LD, Fernández-Lebrero A, García-Escobar G, Navalpotro-Gómez I, Grau-Rivera O, Iaccarino G, Manero-Borràs RM, Ortiz-Romero P, Hernández-Villamizar F, Torres-Torronteras J, de Diego-Osaba M, Blasco-Forniés H, Jiménez-Moyano E, Hernández JJ, Padrós A, Del Campo M, Puig-Pijoan A, Suárez-Calvet M
PubMed: 42832237
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STZ‑induced sporadic Alzheimer's in rats: behavioral, histopathological, and MiRNA profiles.

J Mol Histol. 2026 Oct 5;57(5)
Authors: Moustafa N, Gaballa Z, Haiba S, Abdellatif A
PubMed: 42832125
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Electroacupuncture Targeting the NLRP3 Inflammasome in Senescence‑associated Cognitive Impairment: Mechanistic Synthesis and Meta‑analysis of Clinical Randomized Controlled Trials.

Neurochem Res. 2026 Oct 5;51(5)
Authors: Ma T, Zhou H, Liu Y, Cheng X, Li M
PubMed: 42831987
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The causal relationship between immune cells, white matter microstructure and dementia: a Mendelian randomization study and co-localization analysis.

Eur Arch Psychiatry Clin Neurosci. 2026 Oct 5; Epub 2026 Oct 5
Authors: Meng D, Liang P, Li P, Han Y
PubMed: 42831924
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Emerging therapeutic strategies to target APOE4 in Alzheimer's disease.

FEBS J. 2026 Oct 5; Epub 2026 Oct 5
Authors: Jiang WI, Wang B, Ma DK
PubMed: 42831701
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Reply: Is the entorhinal signal a tau origin or a treatment-relevant vulnerability map?

Brain. 2026 Oct 5; Epub 2026 Oct 5
Authors: Chaggar P, Alexandersen CG, Bassett DS, Goriely A
PubMed: 42831531
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Sciadonic acid ameliorates cognitive impairment in APP/PS1 mice with concomitant modulation of gut microbiota and brain metabolism.

Food Funct. 2026 Oct 5; Epub 2026 Oct 5
Authors: Xie S, Zheng B, Li M, Zheng B, Shen G, Xiang X, Chen L
PubMed: 42831322
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Exploratory Analysis of APOE ε4-Stratified Associations Between Plasma Alzheimer's Biomarkers and Retinal Imaging Metrics in Cognitively Normal Adults.

Transl Vis Sci Technol. 2026 Oct 5;15(10):6.
Authors: Choi A, Haystead A, D'Cunha R, Hsu J, Zhu M, Johnson KG, Lutz MW, Whitson H, Grewal DS, Fekrat S
PubMed: 42836717
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RIPK1 Links Metabolic Stresses to Inflammatory and Degenerative Pathways in Alzheimer's Disease.

Neurosci Bull. 2026 Oct 5; Epub 2026 Oct 5
Authors: Chen X, Zou C
PubMed: 42834253
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External validation of an integrative model of functional impairment in early-stage behavioral variant frontotemporal dementia (bvFTD).

J Neurol. 2026 Oct 5;273(10)
Authors: Chatzidimitriou E, Moraitou D, Ioannidis P, Aretouli E, Chen Y, Rosen HJ, Gorno-Tempini ML, Seeley WW, Miller BL, Rankin KP
PubMed: 42834227
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TBK1 eliminates aggregation-prone monomeric TDP-43 through an IFNβ-immunoproteasome pathway in ALS models.

EMBO Rep. 2026 Oct 5; Epub 2026 Oct 5
Authors: Sakai S, Oiwa K, Iguchi Y, Akcay IM, Watanabe S, Komine O, Nagata N, Horiuchi M, Sreedharan J, Katsuno M, Yamanaka K
PubMed: 42834122
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Retraction Note: LRRK2 kinase regulates α-synuclein propagation via RAB35 phosphorylation.

Nat Commun. 2026 Oct 5;17(1)
Authors: Bae EJ, Kim DK, Kim C, Mante M, Adame A, Rockenstein E, Ulusoy A, Klinkenberg M, Jeong GR, Bae JR, Lee C, Lee HJ, Lee BD, Di Monte DA, Masliah E, Lee SJ
PubMed: 42834056
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Cerebrospinal fluid inflammatory proteomic profiling identifies biomarkers linked to disease progression in amyotrophic lateral sclerosis.

J Neurol. 2026 Oct 4;273(10)
Authors: Lv C, Zhu W, Wen X, Wang Y, Xie N, Liu H, Jiang Y, Zou W, Liu Q, Gou J, Yu X, Di L, Lu Y, Wang M, Xu M, Chen H, Duo J, Huang Y, Da Y
PubMed: 42829893
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A LIFU-responsive phase-change nanoplatform enhances hippocampal galantamine exposure and cognitive outcomes in APP/PS1 mice.

J Biomater Sci Polym Ed. 2026 Oct 4;:1-23. Epub 2026 Oct 4
Authors: Chen Y, Liu Y, Xie J, Wang S, Zhou D, Song G, Dou Y
PubMed: 42830424
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Therapeutic potential of proline-rich peptide-1 (PRP-1) in counteracting amyloid-β-mediated cortical and hippocampal neurodegeneration in a rat model.

Neuroscience. 2026 Oct 3; Epub 2026 Oct 3
Authors: Stepanyan H, Ghorbani H, Poghosyan M, Danielyan M, Minasyan A, Hunanyan A, Hunanyan N
PubMed: 42829100
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A statistical framework for integrative imaging genomics with biclustering and ensemble penalized regression in Alzheimer's disease.

Neuroimage. 2026 Oct 3;341:122267. Epub 2026 Oct 3
Authors: Chen H, He Y, Hou L, Liu L, Ma C, Alzheimer’s Disease Neuroimaging Initiative
PubMed: 42829013
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Exercise, Glucose and Lactate Metabolism in Mild Cognitive Impairment: A Narrative Review.

Int J Sports Med. 2026 Oct 3; Epub 2026 Oct 3
Authors: Kim D, Moon HY, Lee M
PubMed: 42828991
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Corrigendum to "Surface-enhanced Raman spectroscopy of serum exosomes coupled with support vector machine for diagnosis of Parkinson's disease" [Spectrochim. Acta Part A: Molecul. Biomolecul. Spectrosc. 353 (2026) 127573].

Spectrochim Acta A Mol Biomol Spectrosc. 2026 Oct 3;366:128860. Epub 2026 Oct 3
Authors: Liu X, Wei X, Zheng X, Xu L, Wu G, Feng K
PubMed: 42828938
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Synucleins deficiency alter dopamine- and glutamate-induced calcium signal in neurons and astrocytes.

Neurochem Int. 2026 Oct 3;200:106269. Epub 2026 Oct 3
Authors: Fedulina AA, Baev AY, Emelyanov AV, Khizeva AA, Chaprov KD, Vinokurov AY, Abramov AY
PubMed: 42828908
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Improvement of Autonomic and Cognitive Dysfunction by Memantine in a Patient with Dementia with Lewy Bodies and Cardiac Conduction Defect: A Case Report.

Am J Health Syst Pharm. 2026 Oct 3; Epub 2026 Oct 3
Authors: Huang CC, Yeh YC, Hsu CL, Zeng YW, Chen CY, Kuo SC, Yeh YW
PubMed: 42828766
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Multimodal neuroimaging in dementia and neurodegenerative disorders: complementary roles of clinically available nuclear medicine and MRI in the era of disease-modifying therapies.

Jpn J Radiol. 2026 Oct 3; Epub 2026 Oct 3
Authors: Inui Y, Takechi H, Watanabe H, Kato T, Ito K, Kobayashi R, Toyama H, Inoue M
PubMed: 42828695
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Sensory gamma entrainment in older adults with or without cognitive impairment: a systematic review and exploratory meta-analysis.

Geroscience. 2026 Oct 3; Epub 2026 Oct 3
Authors: Hyun M, Park Y, Park SY, Kim KW
PubMed: 42828668
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The immunoproteasome in Alzheimer's disease: a dual regulator of tau pathology and microglial senescence.

Inflammopharmacology. 2026 Oct 3; Epub 2026 Oct 3
Authors: Shokr MM, Abdelaziz AM
PubMed: 42828662
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Stem cells and derived growth factors in Alzheimer's disease: mechanistic insights and translational perspectives.

Inflammopharmacology. 2026 Oct 3; Epub 2026 Oct 3
Authors: Dhapola R, Kumari S, Sharma P, Paidlewar M, Vellingiri B, Cho SG, Dayem AA, Medhi B, HariKrishnaReddy D
PubMed: 42828660
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The Therapeutic Potential of MicroRNAs Delivered By Mesenchymal Stem Cells in Parkinson's Disease, Alzheimer's Disease, and Stroke: A Systematic Review of Preclinical Studies.

Mol Neurobiol. 2026 Oct 3;63(1)
Authors: Przywara D, Petniak A, Gil-Kulik P
PubMed: 42828605
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Exploring the role of glymphatic system in Alzheimer's disease with insights from MRI-based studies: a systematic review.

Neuroradiology. 2026 Oct 3; Epub 2026 Oct 3
Authors: Bernetti C, Calandrelli R, Pilato F, Di Lazzaro V, Zobel BB, D'Amelio M, Mallio CA
PubMed: 42828568
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From Helicobacter pylori CagA to Cross-Kingdom Amyloid Control: Emerging Anti-amyloid Biology, Mechanistic Paradoxes, and Translational Opportunities.

Protein J. 2026 Oct 3; Epub 2026 Oct 3
Authors: Habib YH, Barakat YA
PubMed: 42829425
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Association between BDNF methylation and expression of the NLRP3 inflammasome in the brain is disrupted in Alzheimer's disease.

J Neural Transm (Vienna). 2026 Oct 3; Epub 2026 Oct 3
Authors: Tang H, Fachim HA, Harte MK, Reynolds GP
PubMed: 42829399
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Tyrosine nitration: An emerging mechanistic landscape in neurodegeneration and cardiopulmonary disease.

Redox Biol. 2026 Oct 3;97:104423. Epub 2026 Oct 3
Authors: Adrita N, Claassen I, Huerta M, Black SM, Estevez AG, Roberts BR, Beckman JS, Franco MC
PubMed: 42843275
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D90N and D90K mutations in the chaperonin OBP reduce its ability to induce fibrillation of the prion protein by decreasing ATPase activity.

Biochim Biophys Acta Gen Subj. 2026 Oct 2;:131012. Epub 2026 Oct 2
Authors: Pozdyshev DV, Orlov VN, Kirpichenko MV, Kudryavtseva SS, Oleynikov IP, Golyshev SA, Muronetz VI, Kurochkina LP
PubMed: 42826842
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Microglial GPR56 in synaptic pruning: mechanisms, comparative receptor biology, and context-dependent roles in brain disorders.

Biochim Biophys Acta Mol Cell Res. 2026 Oct 2;:120231. Epub 2026 Oct 2
Authors: Chaudhari A, Goyal S
PubMed: 42826818
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Mdivi-1 regulates mitochondrial fission and function via the CaMK2/Drp1 pathway in amyotrophic lateral sclerosis.

Neuroscience. 2026 Oct 2; Epub 2026 Oct 2
Authors: Shai Y, Alam M, Dong X, Zhang Y, Hu Y, He Z, Feng J, Chen Y, Zhou Z, Jiang H
PubMed: 42826761
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Identification of a shared blood-brain transcriptomic signature in Parkinson's disease using bioinformatic and network pharmacology approaches.

Neuroscience. 2026 Oct 2; Epub 2026 Oct 2
Authors: Mohammad H, Singh A, Bansal D
PubMed: 42826760
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Ruscus aculeatus Extract Inhibits Amyloid Beta Production and Upregulates the Active form of ADAM10 in Human Neural Progenitor Cells.

Planta Med. 2026 Oct 2; Epub 2026 Oct 2
Authors: Murata K, Mizushina Y, Izawa D, Matsui Y, Wakabayashi T, Hashimoto T, Iwatsubo T, Matsushima Y
PubMed: 42826722
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From patient cells to patient therapy: Twenty years of iPSC-based translation in neurodegenerative disease.

Cell Rep Med. 2026 Oct 2;:103104. Epub 2026 Oct 2
Authors: Cha Y, Kim KS
PubMed: 42826718
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Cyclic nucleotide signaling through phosphodiesterase 1 inhibition and its interaction with the competing endogenous RNA network regulates cognition.

Biomed Pharmacother. 2026 Oct 2;204:119963. Epub 2026 Oct 2
Authors: Xu F, Li H, Yan Y, Chen L, Sheng Z, Dou B, Yan C, Zhu X, Xu Y
PubMed: 42826681
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Systemic inflammation, gut microbiome composition, and cognitive performance among older Ugandans with Alzheimer's disease and related dementias: A cross-sectional study.

Medicine (Baltimore). 2026 Oct 2;105(40):e50956.
Authors: Lwere K, Nakasujja N, Muwonge H, Sendagire H, Gumikiriza-Onoria JL, Buwembo D, Buwembo W, Kabwigu S, Mukasa JK, Kirya F, Nazziwa A, Othieno E, Nassanga R, Nakimbugwe R, Munabi IG, Sajatovic M, Kaddumukasa M
PubMed: 42826310
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Prevalence of metabolic syndrome among patients with Alzheimer disease: A systematic review and meta-analysis.

Medicine (Baltimore). 2026 Oct 2;105(40):e50670.
Authors: Amouzad-Lichahi M, Petkov I, Smerat A, Alsarhan HW, Letafatkar N, Abbasnejad-Ardehroudkenari M, Mohammadi S, Jafari M, Ghodous S, Amini-Salehi E
PubMed: 42826267
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Bisphenol A Exposure Perturbs the Immune Microenvironment in Alzheimer's Disease: Insights from Network Toxicology and Single-Cell Transcriptomics.

J Mol Neurosci. 2026 Oct 2;76(4)
Authors: Wu J, Wang Y, Zhao M, Liu J, Zhao W
PubMed: 42825974
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Incidence, severity, and associated risk factors for amyloid-related imaging abnormalities in anti-amyloid monoclonal antibody therapy for early Alzheimer's disease: a systematic review and meta-analysis.

Neurol Sci. 2026 Oct 2;47(10)
Authors: Martinez Holst MA, Sierra Valiente AM, Garcia-Becerra CA
PubMed: 42825842
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Culture-Agnostic and Culture-Specific Analyses of Semantic Fluency in Korean and English Speakers With Alzheimer's Disease.

Am J Speech Lang Pathol. 2026 Oct 2;:1-14. Epub 2026 Oct 2
Authors: Shin J, García AM, Scimeca M, Kiran S, Sung JE
PubMed: 42825683
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Molecular and genetic basis of alzheimer's disease and emerging treatment Modalities.

Neurodegener Dis Manag. 2026 Oct 2;:1-21. Epub 2026 Oct 2
Authors: Varshney H, Siddique YH
PubMed: 42825454
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Associations Between Prediagnosis Plasma Neurofilament Light Polypeptide and Amyotrophic Lateral Sclerosis Risk in the Danish EPIC Cohort.

Ann Neurol. 2026 Oct 2; Epub 2026 Oct 2
Authors: Davias A, Hansen J, Akdis CA, Weisskopf MG
PubMed: 42825398
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Memory and Plasma pTau217 Refine Prognosis in Down Syndrome.

Ann Neurol. 2026 Oct 2; Epub 2026 Oct 2
Authors: Vanderlip CR, Hartley SL, Krinsky-McHale S, Hom C, Brickman AM, Petersen ME, Head E, Stark CE, Alzheimer's Biomarker Consortium—Down Syndrome (ABC‐DS) Study Team
PubMed: 42825390
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Gene regulatory co-expression networks decipher potential lncRNA-miRNA-mRNA interactions modulating transcription regulation in neurodegeneration.

Comput Biol Chem. 2026 Oct 2;126(Pt 2):109462. Epub 2026 Oct 2
Authors: Venkatesan A, Sinha P, Basak J, Bahadur RP
PubMed: 42843091
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Structural heterogeneity of CTE Type I tau filaments with an interface-shifted polymorph.

Biochem Biophys Res Commun. 2026 Oct 1;838:154679. Epub 2026 Oct 1
Authors: Watanabe R, Lee EB
PubMed: 42826653
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Progressive remodeling of global protein interaction networks in a mouse model of tauopathy.

Cell Rep. 2026 Oct 1;45(10):118084. Epub 2026 Oct 1
Authors: Lin W, Phanse S, van der Spek SJ, Lampl N, Stephens MC, Wang Z, Nigro JT, Ortiz AR, Hekman R, Cruz AL, Roberts R, Jiang L, Botas J, Emili A, Wolozin B
PubMed: 42826098
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AMPK Activator MK-8722 Improves Spatial Memory Deficit and Alters Metabolome in APP/PS1 AD Mouse Model.

J Neurochem. 2026 Oct;170(10):e70563.
Authors: Nicol NI, Li T, Su Q, Suhocki A, Dunlap E, Zhou X, Jester HM, Swift NA, Underwood E, Lee J, Cervera-Juanes R, Ma T
PubMed: 42825521
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In vivo detection of pathologic α- synuclein and TDP-43 in the skin and olfactory mucosa of a patient with Parkinson's disease-like phenotype carrying the p.Thr272Serfs*10 GRN mutation.

Mol Neurodegener. 2026 Oct 1;21(1)
Authors: Caroppo P, Aprea V, Villa C, Dellarole IL, Romeo A, Rossi G, Ciullini A, Burato A, Prioni S, Grisoli M, Legname G, Simmini G, Luppino A, Mazzetti S, Moda F, Devigili G
PubMed: 42823745
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From Design to Bedside: Brain-Targeted Engineered Nanoparticles and Predictive Modeling for Neurodegenerative Diseases Therapeutics.

Pharm Res. 2026 Oct 1; Epub 2026 Oct 1
Authors: Nguyen N, Yuan M, Wang Y
PubMed: 42823573
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Insertion or deletion variants in TAF15 exon 15 are genetic factors impacting the prognosis of amyotrophic lateral sclerosis in a Japanese cohort.

Eur J Hum Genet. 2026 Oct 1; Epub 2026 Oct 1
Authors: Hatano Y, Ishihara T, Tada M, Li Y, Hirokawa S, Uemura M, Ando S, Yokoseki A, Kakita A, Onodera O
PubMed: 42823490
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Different functional connectivity gradients reflect aging and Alzheimer's disease.

Nat Neurosci. 2026 Oct 1; Epub 2026 Oct 1
Authors: Rittmo J, Franzmeier N, Strandberg O, Chauveau L, Satterthwaite TD, Wisse LE, Spotorno N, Behjat HH, Dehsarvi A, van Westen D, Anijärv TE, Alzheimer’s Disease Neuroimaging Initiative, Landau SM, Palmqvist S, Janelidze S, Stomrud E, Ossenkoppele R, Mattsson-Carlgren N, Hansson O, Vogel JW
PubMed: 42823476
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Systems-level bioinformatics analysis of hsa-miR-132-3p targets identifies a conserved neuroimmune regulatory module relevant to Alzheimer's disease.

Comput Biol Chem. 2026 Oct 1;126(Pt 1):109445. Epub 2026 Oct 1
Authors: Soltani I, Bahia W, Slaymi C, Khemissi W, Rahali N, Bougatef H, Baazaoui N, Ferchichi S, Almawi WY
PubMed: 42828976
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Correction to 'Beyond Bulk: Cell-Type-Resolved Epigenomics as the Path Forward in Alzheimer's Disease Research'.

Eur J Neurosci. 2026 Oct;64(7):e70696.
Authors:
PubMed: 42834006
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Potential misclassification of probable sporadic Creutzfeldt-Jakob disease diagnosed without PRNP testing.

J Neurol Sci. 2026 Oct 1;491:126197. Epub 2026 Oct 1
Authors: Kosami K, Hamaguchi T, Kishida H, Kuwabara M, Satoh K, Kitamoto T, Yamda M, Mizusawa H, Ae R
PubMed: 42833012
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Why are some neurons spared in neurodegeneration? Cellular subtype identity maintenance as a candidate threshold-setting mechanism.

PLoS Biol. 2026 Oct;24(10):e3004014. Epub 2026 Oct 5
Authors: Kim DW
PubMed: 42832419
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[Two trials, one result: oral semaglutide does not slow cognitive decline in early Alzheimer disease.].

Recenti Prog Med. 2026 Oct;117(10):472-473.
Authors: Kurotschka PK, Barry H
PubMed: 42831714
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Structural compression and entorhinal vulnerability: Linking tentorial adjacency to tau burden and dementia progression.

Alzheimers Dement. 2026 Oct;22(10):e71827.
Authors: Zhang L, Franceschi AM, Crary JF, Provenzano FA, Alzheimer's Disease Neuroimaging Initiative
PubMed: 42831470
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Study design and results of the Wave VI Add Health Cognitive Assessment, Physical, and Sensory Function (Add CAPS) protocol.

J Gerontol B Psychol Sci Soc Sci. 2026 Oct 1;81(Supplement_2):S114-S124.
Authors: Aiello AE, Stebbins RC, Parker CN, Rob FI, Martin CL, Rojas NB, Bennett DA, Manly JJ, Plassman BL, Reed NS, Myers CA, Batsis JA, Hummer RA
PubMed: 42837504
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Insights Into the Role of Platelet Factor 4 in Neurodegenerative Diseases.

CNS Neurosci Ther. 2026 Oct;32(10):e71118.
Authors: Tian Q, Tong Y, Yu F, Hu X
PubMed: 42837273
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Cognitive impairment in Parkinson disease correlates with loss of cholinergic axon projections to cortex in an autopsy study.

Alzheimers Dement. 2026 Oct;22(10):e71868.
Authors: Miller R, O'Shea J, Rosok LM, Lim S, Franklin EE, Perrin RJ, Hwang H, Dhavale D, Perlmutter J, Campbell MC, Kotzbauer P
PubMed: 42836773
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A murine model of amyloid enhanced tauopathy: progressive changes in tau pathology and behavior.

Alzheimers Dement. 2026 Oct;22(10):e71839.
Authors: Finneran DJ, Desjarlais T, Jackman BM, Morgan D, Gordon MN
PubMed: 42836759
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Longitudinal untargeted metabolomics of cognitive impairment in Parkinson's disease.

Alzheimers Dement. 2026 Oct;22(10):e71890.
Authors: Lin Y, Yu Y, Zhang K, Del Rosario I, Duarte Folle A, Mayeda ER, Jones DP, Walker DI, Bronstein J, Keener AM, Paul KC, Ritz B
PubMed: 42836749
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A murine model of amyloid-enhanced tauopathy: Comparison of wild-type and P301L-tau.

Alzheimers Dement. 2026 Oct;22(10):e71788.
Authors: Finneran DJ, Desjarlais T, Jackman BM, Gordon MN, Morgan D
PubMed: 42836747
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Cell-based polygenic risk scores predict clinical progression and prioritize network-based therapeutic targets in Alzheimer's disease.

Alzheimers Dement. 2026 Oct;22(10):e71895.
Authors: Sahelijo N, Rajagopalan P, Qian L, Rahman R, Goldstein D, Thomopoulos SI, Bennett DA, Farrer LA, Stein TD, Shen L, Huang H, Nho K, Saykin AJ, Davatzikos C, Thompson PM, Tcw J, Jun GR
PubMed: 42836738
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Clusterin is enriched in plaque-associated astrocytes and localizes to synapses in Alzheimer's disease.

Alzheimers Dement. 2026 Oct;22(10):e71885.
Authors: Byrne RA, Veteleanu A, Cramp HL, Bacon OG, Baillie KL, Bright M, Cooke RS, Fenn GD, Flores Castelán M, Lee KY, Zelek WM, Morgan BP, Daskoulidou N
PubMed: 42836734
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Recent advances of GPR40 agonists as potential anti-Alzheimer's agents.

Future Med Chem. 2026 Oct;18(20):2953-2968. Epub 2026 Oct 6
Authors: da Silva JM, Kümmerle AE, Rodrigues DA, Bolognesi ML, Milelli A, Lima LM, de Sena Murteira Pinheiro P
PubMed: 42836463
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Investigating the molecular mechanisms underlying the neuroprotective potential of ellagic acid in scopolamine-induced learning and memory dysfunction.

Res Pharm Sci. 2026 Oct;21(5):566-581. Epub 2026 Sep 8
Authors: Rajabian A, Assaran AH, Mirzavi F, Akbarian M, Salmani H, Beheshti F, Rastegar-Moghaddam SH, Saberi R, Azadmanesh A, Hosseini M
PubMed: 42836188
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Genetic and Pharmacological Targeting of Hsp72 Overexpression/Induction in an Alzheimer's Disease Mouse Model With Combined Amyloid and Tau Pathology.

J Neurosci Res. 2026 Oct;104(10):e70161.
Authors: Marshall JP, Harutyunyan A, Ng J, West OM, Collins JM, King AE, Morizzi J, Wright P, Calkin AC, Drew BG, Jones NC, Adlard PA, Febbraio MA, Henstridge DC
PubMed: 42834737
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Multimodal PET/MRI radiomics model for the classification of Alzheimer's disease and other dementia subtypes: A multicenter study.

Med Phys. 2026 Oct;53(10):e70690.
Authors: Wang B, Bi S, Xu X, Zheng H, Liang D, Mok GS, Yan S, Hu Z
PubMed: 42834546
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Network-dependent remote effects and local tau burden jointly shape neuronal dysfunction in Alzheimer's disease.

Alzheimers Dement. 2026 Oct;22(10):e71914.
Authors: Frontzkowski L, Roemer-Cassiano S, Gnörich J, Janowitz D, Eyob H, Probst K, Dhoqina D, Dewenter A, Steward A, Zhu Z, Klonowski M, Hirsch F, Biel D, Paulus M, Vöglein J, Schönecker S, Rauchmann BS, Kurz C, Koriath C, Häckert J, Stöcklein S, Palleis C, Perneczky R, Levin J, Buerger K, Werner RA, Höglinger G, Brendel M, Franzmeier N
PubMed: 42842336
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The value of timely treatment with anti-amyloid therapy for Alzheimer's disease.

Alzheimers Dement. 2026 Oct;22(10):e71819.
Authors: Chapel JM, Tysinger B, Pourmand H, Goldman D, Aisen P, Alzheimer's Disease Neuroimaging Initiative
PubMed: 42841389
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Genetic evidence supports a cortical neuroprotective role of GLP-1 receptor activation in Alzheimer's disease: A drug-target Mendelian randomization study.

Alzheimers Dement. 2026 Oct;22(10):e71845.
Authors: Jiang L, Chen X, Qian J, Fang K, Dai C, Chang D, Jin L, Huang W, Wang Y, Duan X, Wan J, Li M, Zhang W, Li J, Xiao Z, Wu H, Meng Q, Tang B
PubMed: 42841315
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Longitudinal clinical outcomes after amyloid clearance in aducanumab phase 3 studies.

Alzheimers Dement. 2026 Oct;22(10):e71758.
Authors: Pang M, Brothers HM, O'Gorman J, Murphy J, Zabar Y, Lasky T, Shen C, Rubino I, Knopman D
PubMed: 42841310
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miR-214-3p and NCKAP1: A microglial functional dimension of Alzheimer's progression.

Alzheimers Dement. 2026 Oct;22(10):e71903.
Authors: Noh MY, Moon Y, Kang S, Moon WJ, Kim HJ, Seo SW, Ahn S, Kang MH, Kim YS, Kim H, Bae JS, Jin HK, Choi H, Koh SH, Park KH, Day GS, Bu G, Kim SH
PubMed: 42841306
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Profiling Gut Microbiome and Metabolites Aids Diagnosis and Prediction of Progression in Mild Cognitive Impairment.

MedComm (2020). 2026 Oct;7(10):e71045. Epub 2026 Oct 6
Authors: Zhang B, Brown R, Bayer A, Waring J, Morgan BP, Marchesi JR, Zhou Y
PubMed: 42840456
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Recalibration of the Frontal Behavioural Inventory Cut-Off for Behavioural Screening in Amyotrophic Lateral Sclerosis.

Eur J Neurol. 2026 Oct;33(10):e70778.
Authors: Iazzolino B, Palumbo F, Canosa A, Callegaro S, Passidomo V, Manera U, Vasta R, Matteoni E, Cabras S, Pellegrino G, Maccabeo A, Moglia C, Calvo A, Chiò A
PubMed: 42839768
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Increased Expression of α-Synuclein Impairs Trafficking of the Essential SNARE Protein Synaptobrevin-2.

J Neurochem. 2026 Oct;170(10):e70568.
Authors: Arvell EH, Carroll JP, Saito J, Melland H, Unnithan RR, French C, Hatters DM, Gordon SL
PubMed: 42847534
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Association of Reproductive Factors and Postmenopausal Sex Hormones With Cognitive Impairment in Postmenopausal Women With Parkinson's Disease.

CNS Neurosci Ther. 2026 Oct;32(10):e71182.
Authors: Hu WZ, Wang Q, Tang L, Wang JQ, Hu D, Wu TT, Huang Y, Shi ZH, Ren Y, Wan ZR, Xu PY
PubMed: 42847423
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Comorbidities and health-care use prior to early-onset Alzheimer's disease: A population-based case-control study.

Alzheimers Dement. 2026 Oct;22(10):e71831.
Authors: Leppänen L, Lehtonen A, Aaltonen M, Aho K, Kivisild A, Ullgren A, Rinnankoski I, Soppela H, Haapasalo A, Portaankorva AM, Hartikainen P, Katisko K, Solje E, Krüger J
PubMed: 42847312
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Trigonelline Alleviates Neuroinflammation in AAV-SynA53T Parkinson's Disease Model Mice: Involvement of PI3K/AKT-NF-κB Signaling and Gut Microbial-Metabolic Remodeling.

Food Sci Nutr. 2026 Oct;14(10):e72451. Epub 2026 Oct 6
Authors: Chen M, Dong Y, Zheng J, Lin Y, Li Q, Wei C, Zhuo L, He Y, Sun J, Fu F, Liu J
PubMed: 42846692
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Numeracy and recall of Alzheimer's disease risk information: Effects of risk format in a Latino community.

Patient Educ Couns. 2026 Sep 30;154:110330. Epub 2026 Sep 30
Authors: Rodriguez S, Wetmore JB, Diaz Caro D, Cabán M, Uhlmann WR, Roberts JS, Siegel K, Ottman R
PubMed: 42826610
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High-resolution genomic architecture of a 1.71-Mb inverted SNCA triplication in a patient-derived PARK4 model.

Biochem Biophys Res Commun. 2026 Sep 30;839:154675. Epub 2026 Sep 30
Authors: Okano A, Miya F, Kosaki K, Nakahara J, Ito D
PubMed: 42837812
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Quantitative handwriting measures discriminate between older adults with and without MMSE-defined cognitive impairment.

Arch Gerontol Geriatr. 2026 Sep 30;152:106436. Epub 2026 Sep 30
Authors: Devoli G, Alì PA, Schiavetti I, Balestrino M
PubMed: 42837746
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Structural optimization of donepezil-like hybrids toward an improved multi-target and ADME-related profile.

Bioorg Chem. 2026 Sep 29;183:110599. Epub 2026 Sep 29
Authors: Paparella M, Leuci R, Cerini M, Simic S, Chaves S, Carrieri A, Loiodice F, Tortorella P, Laghezza A, Wackerlig-Damle J, Santos MA, Piemontese L
PubMed: 42826663
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AI-driven transcriptomics for neurodegenerative disease research: A systematic review.

Comput Biol Chem. 2026 Sep 29;126(Pt 1):109448. Epub 2026 Sep 29
Authors: Tripathi A, Yadav AK, Kumar N
PubMed: 42826575
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Machine Learning-Guided Discovery of Natural BACE1 Inhibitors with Enzymatic and Cellular Validation.

ACS Omega. 2026 Sep 29;11(38):58100-58111. Epub 2026 Sep 16
Authors: Bai Y, Zhao J, Zhang S, Yan C, Chen Y, Du G, Liu A
PubMed: 42824999
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MRI-derived choroid plexus volume and longitudinal cognitive decline in Parkinson's disease.

Parkinsonism Relat Disord. 2026 Sep 28;153:109006. Epub 2026 Sep 28
Authors: Lv QK, Zhou ZQ, Shi LY, Gao F, Wang F, Cheng XY, Zhang JR, Chen Y, Mao CJ, Liu CF
PubMed: 42837908
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Portable microcontroller-based impedance analyzer equipped with molecularly imprinted polymer for sensitive and specific detection of amyloid beta.

Talanta. 2026 Sep 27;313(Pt A):130684. Epub 2026 Sep 27
Authors: Hongoeb J, Phopin K, Tantimongcolwat T, Ruankham W, Mukhopadhyay SC
PubMed: 42837779
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Individuals with dementia with lewy bodies exhibit worsened reactive walking balance responses to treadmill-induced perturbations than matched controls.

Gait Posture. 2026 Sep 26;132:110648. Epub 2026 Sep 26
Authors: Eichenlaub EK, Bozoki A, Mercer V, Franz JR
PubMed: 42832981
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CRISPR screening in neurodegeneration and lysosomal biology: Uncovering disease mechanisms and genetic modifiers.

Mol Genet Metab. 2026 Sep 24;149(3):110265. Epub 2026 Sep 24
Authors: Esmaeili H, Das S, Rytel K, Sidransky E, Chen Y
PubMed: 42826647
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Rational design, synthesis, and biological evaluation of indole-piperazine based α-ketoamide derivatives as dual Aβ and tau aggregation modulators for Alzheimer's disease.

Eur J Med Chem. 2026 Sep 24;320:119353. Epub 2026 Sep 24
Authors: Das B, Baidya AT, Chouhan D, Gupta HK, Thakur B, Darreh-Shori T, Chen G, Tiwari V, Kumar R
PubMed: 42826515
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Site-specific phosphorylation of Ser352 drives aggregation of Tau R4 under acidosis conditions.

Chem Sci. 2026 Sep 24; Epub 2026 Sep 24
Authors: Bressler SG, Blacher C, Harpaz KA, Grunhaus D, Rüdiger SG, Hurevich M, Shalev DE, Miller Y, Friedler A
PubMed: 42827801
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Gather-excite attention-driven deep learning model for Alzheimer disease detection from MRIs using adaptive residual-DenseNet strategy.

Psychiatry Res Neuroimaging. 2026 Sep 24;364:112344. Epub 2026 Sep 24
Authors: Mohan R, Mali S, Ilango P, Jainulabdeen J
PubMed: 42837878
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Sleep-dependent microglial functions in Alzheimer's disease.

Trends Neurosci. 2026 Sep 22; Epub 2026 Sep 22
Authors: Calafate S, Mancuso R
PubMed: 42850105
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Expression of Concern to "Increased expression of heat shock proteins in rat brain during aging relationship with mitochondrial function and glutathione redox state" [Mech. Ageing Dev. 125(2004) 325-35].

Mech Ageing Dev. 2026 Sep 12;:112256. Epub 2026 Sep 12
Authors: Calabrese V, Scapagnini G, Ravagna A, Colombrita C, Spadaro F, Butterfield DA, Stella AM
PubMed: 42805815
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Parkinson's disease-associated LRRK2 risk variant, G2385R, enhances Rab substrate phosphorylation and impairs neuronal integrity.

Hum Mol Genet. 2026 Sep 11;35(20)
Authors: Nguyen AP, Moser R, Bryant N, Cunningham LA, Worden EJ, Moore DJ
PubMed: 42837290
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Multisite Anodal Direct Current Stimulation Preserves Motor Function and Modulates Key Cellular Pathways in TDP-43 and SOD1 Mouse Models of Amyotrophic Lateral Sclerosis.

Neuromodulation. 2026 Sep 3; Epub 2026 Sep 3
Authors: Morozova V, Hassieb M, Ahmed Z
PubMed: 42831851
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Dual effect of α-synuclein disease variants on condensate formation.

Nat Commun. 2026 Sep 2;17(1)
Authors: Chandran A, Agarwal A, Wang T, Amaral L, Chen S, Chaves SR, Outeiro TF, Lautenschläger J
PubMed: 42823411
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Integrative Transcriptomic Analysis Characterizes the Gene Expression Patterns of RNA G-Quadruplex-Associated Genes in Parkinson's Disease.

Cureus. 2026 Sep;18(9):e115629. Epub 2026 Sep 1
Authors: Barve A, Saini N
PubMed: 42828052
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DNA Methylation of the SNCA Intron 1 and Alpha-Synuclein Expression in the CD45+ Blood Cells in Parkinson's Disease.

Biochemistry (Mosc). 2026 Sep;91(9):1629-1643.
Authors: Lavrinova AO, Litusova EM, Dmitriev AA, Melnikova NV, Pidyurchina VN, Kulabukhova DG, Syreva OV, Miliukhina IV, Timofeeva AA, Berkovich OA, Pchelina SN, Emelyanov AK
PubMed: 42830106
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mTOR and STING Modulation Restores Hydrolase Activities and Decreases Alpha-Synuclein Pathology in the Cells from the Patients with GBA1-Associated Parkinson's Disease.

Biochemistry (Mosc). 2026 Sep;91(9):1596-1614.
Authors: Usenko TS, Bezrukova AI, Basharova KS, Grigor'eva EV, Pavlova SV, Baydakova GV, Miliukhina IV, Zakharova EY, Pchelina SN
PubMed: 42830104
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Astrocyte Structure-Function Relationship in Senescence and Neurodegeneration.

Biochemistry (Mosc). 2026 Sep;91(9):1522-1549.
Authors: Serebryanaya DV, Kolgaeva KA, Dya GA, Ermakov IM, Belousov VV
PubMed: 42830099
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Mapping Lymphatic Drainage from the Human Brain to the Head and Neck: Potential Surgical Implications for Dementia.

Arch Plast Surg. 2026 Sep;53(5):427-438. Epub 2026 Aug 21
Authors: Nguyen DH, Higueras C, Suami H, Carrera Burgaya A, Hong JP
PubMed: 42835887
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[Early Onset and Independence of Prospective Memory Impairments in Alzheimer's Disease - A Challenge for Diagnosis].

Geriatr Psychol Neuropsychiatr Vieil. 2026 Sep 1;24(3):289-301.
Authors: Eygasier J, Piolino P, Baudouin A
PubMed: 42842820
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Effects of an eight-week combined exercise program on functional and sarcopenia-related outcomes in institutionalized older adults with and without Alzheimer's disease: a comparative intervention study.

BMC Geriatr. 2026 Aug 31;26(1)
Authors: Kavlak Y, Yıldız S, Yıldız P, Kar F
PubMed: 42823667
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Forced treadmill running and ladder climbing physical activity attenuates cognitive decline and protein aggregates in aged 3xTg-AD mice.

Mol Brain. 2026 Jul 23;19(1)
Authors: Yang M, Ouyang X, Gautam S, Singleton M, Davydzenka V, Zhang J, Li Y
PubMed: 42844635
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Oral microbiome-metabolome axis links glycerophospholipid dysregulation to Alzheimer's disease.

J Oral Microbiol. 2026;18(1):2732297. Epub 2026 Sep 29
Authors: Jia M, Yang R, Xu Y, Wu Z, Lu J, Li Z, Yan Q, Fan G, Gui Y
PubMed: 42825245
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Cellular prion protein levels modulate nigrostriatal vulnerability to α-synuclein oligomers in Parkinson's disease.

Front Neurosci. 2026;20:1913279. Epub 2026 Sep 17
Authors: de Souza Júnyor F, Leser FS, de Souza Albuquerque S, de Barros-Telles R, Heimfarth L, da Silva Andrade B, Furtado CM, da Silva LF, Dos Santos FC, de Oliveira AL, Ferreira ST, Braga C, da Fonseca CG, Neves GA, Romão L, Lima FR
PubMed: 42824715
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From seeds to symptoms: the molecular landscape of tau seeding in Alzheimer's disease.

Front Neurosci. 2026;20:1927017. Epub 2026 Sep 17
Authors: Miao J, Xue C, Yan X, Gu J, Chu D, Sun H
PubMed: 42824632
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New Alzheimer's disease diagnostics and psychological clinical perspectives.

Front Psychol. 2026;17:1866853. Epub 2026 Sep 17
Authors: Aversi MT, Freitas PM, Aversi-Ferreira TA
PubMed: 42824359
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Evaluation of plasma neurofilament and glial fibrillary acidic protein to predict or detect amyloid related imaging abnormalities.

Alzheimers Dement (Amst). 2026;18(4):e70446. Epub 2026 Sep 30
Authors: Schwartz NU, Ellingson T, Nguyen H, Lin Z, Ashton NJ, Dage JL, Deniz K, Dietz CD, Ljubenkov PA, Miller BL, Nael K, Possin K, Rojas JC, Rosen HJ, Saloner R, Soleimani-Meigooni DN, Staffaroni AM, Stephens ML, Tammewar G, Wang Y, La Joie R, Rabinovici GD, Boxer AL, VandeVrede L
PubMed: 42824090
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Cerebral microbleed assessment on MRI in a memory clinic: Reliability, prevalence, and implications for anti-amyloid therapy.

Alzheimers Dement (Amst). 2026;18(4):e70472. Epub 2026 Sep 30
Authors: Privšek E, Marseglia A, Košutić I, Rosenberg A, Granberg T, Kramberger MG, Kivipelto M, Westman E
PubMed: 42824080
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Exploratory effects of coffee-derived exosome-like nanoparticles in a fibrillar amyloid-beta 1-42-induced neurodegenerative rat model: evidence from fluorodeoxyglucose positron emission tomography and phosphorylated tau/amyloid precursor protein expression.

PeerJ. 2026;14:e21739. Epub 2026 Sep 29
Authors: Kucukbagriacik Y, Saribas GS, Ates K, Ozturk C, Kahyaoglu E, Kislal S, Akgul CC, Karacalioglu AO, Goksoy C, Kantarcioglu M
PubMed: 42828019
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Diffusion tensor image analysis along the perivascular space (DTI-ALPS) in Parkinson's disease patients with subjective cognitive decline.

Front Aging Neurosci. 2026;18:1935631. Epub 2026 Sep 18
Authors: Wei S, Qiu M, Gong M, Zou W, Ren J, Qiu W
PubMed: 42827547
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SPORADIC CREUTZFELDT-JAKOB DISEASE: CLINICAL FEATURES, DIAGNOSIS AND THERAPEUTIC HORIZONS.

Georgian Med News. 2026;(376-377):181-189.
Authors: Shala A, Shala N, Jashari F, Jashari B, Jashari R
PubMed: 42830052
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Neutrophil Extracellular Traps Mediate in vitro and in vivo Degradation of α-Synuclein Amyloid Fibrils.

J Inflamm Res. 2026;19:610777. Epub 2026 Sep 29
Authors: Cardim-Pires TR, Martins AD, Guimarães FV, De Mattos TR, Lepinay E, Saint-Pierre M, Cicchetti F, Saraiva EM, Silva PM, Foguel D
PubMed: 42829700
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GLP-1 Receptor Agonists Versus DPP-4 Inhibitors and Incident Dementia Risk in COVID-19 Survivors with Type 2 Diabetes: A Target Trial Emulation Study.

Drug Des Devel Ther. 2026;20:638249. Epub 2026 Sep 30
Authors: Hung KC, Yu TS, Liu PH, Lai YC, Chen IW
PubMed: 42831108
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Utilizing a Drosophila Larval Model of Synucleopathy to Explore Mushroom Extract Treatments for Parkinson's Disease.

MicroPubl Biol. 2026;2026 Epub 2026 Sep 19
Authors: Perry S, Davis F, Patel V, Alvarado R, Black M, Bretanys Desca J, Briggs M, Buck J, Campbell J, Carter E, Clark D, Collins A, Curtis C, Denker S, Gillard M, Goldammer L, Gorman T, Grayson C, Heller D, Holmes Cerveny K, Izaguirre J, James C, Jeffries K, Johnson S, Keeler E, Kincade P, Lambert E, Malagon D, Marks E, Mcgeshick J, McKinney S, Melendrez Z, Mignano G, Miller J, Miller H, Perales J, Pun C, Rollet T, Ross S, Rourke D, Ryan C, Slinker C, Spann-Mcdonald Z, Spurk J, Steele M, Sylvester E, Turpen S, Upshaw T
PubMed: 42830874
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Salivary Extracellular Vesicle Proteome as a Molecular Bridge Between Periodontitis and Neurodegeneration: Mechanisms, Biomarkers, and Therapeutic Opportunities.

ASN Neuro. 2026;18(1):2736964. Epub 2026 Oct 6
Authors: Azhar M, Malviya R, Vandana, Chandra P, Sridhar SB, Shareef J, Wadhwa T, Arockiam D
PubMed: 42836857
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Engineered Source-Specific Extracellular Vesicles for Neurodegenerative Diseases: From Biological Barriers to Targeted Delivery Strategies.

Int J Nanomedicine. 2026;21:636187. Epub 2026 Sep 30
Authors: Li H, Jiang S, Liu X, Zhang J, Hu Y, Liu B, Wu M, Li H, Li B
PubMed: 42835648
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Exploring the role of infectious pathogens in Alzheimer's disease neuroinflammation.

Front Cell Infect Microbiol. 2026;16:1919289. Epub 2026 Sep 21
Authors: Vaiasicca S, Mangiaterra G, Citterio B, Piccioni G, Orlando F, Giorgetti B, Cianfruglia L, Giacconi R, Fumarola S, Cardelli M, Biscetti L, Pelliccioni P, Casoli T, Pelliccioni G
PubMed: 42835465
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Global research architecture of RNA-binding proteins in neurodegenerative diseases: a web of science bibliometric study with PubMed record verification, 2001-2025.

Front Aging Neurosci. 2026;18:1967205. Epub 2026 Sep 21
Authors: Zhu R, Li H
PubMed: 42835448
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Ultrasound neuromodulation in brain disorders: from mechanotransduction mechanisms to clinical translation.

Front Neurosci. 2026;20:1942293. Epub 2026 Sep 21
Authors: Zhang R, Li L, Tang J, Hu S, Zhang Q, Tan J
PubMed: 42835402
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Icariside II protects against neuronal injury by modulating PI3K/AKT-dependent mitochondrial dynamics and apoptosis in Alzheimer's disease models.

Front Pharmacol. 2026;17:1911518. Epub 2026 Sep 21
Authors: Shan SY, Bai JM, Tian Y, Shen YF, Zhang YX, Cheng YH, Liu Y, Ning HY, Min DY, Ren L, Xiao HH
PubMed: 42835365
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Editorial: Biofluid biomarkers for the diagnosis of neurodegenerative diseases: current status.

Front Neurosci. 2026;20:1985558. Epub 2026 Sep 21
Authors: Decourt B, Mielke MM, Slowey PD, Sabbagh MN
PubMed: 42835159
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Associations between cerebrospinal fluid biomarkers related to endothelial dysfunction and Alzheimer's disease.

Front Aging Neurosci. 2026;18:1744647. Epub 2026 Sep 21
Authors: Zhu YK, Zhu QJ, Wang LY, Hu HY, Wang XJ, Zhang ZH, Zhang W, Tan L, Hu H
PubMed: 42835131
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Burden-dependent associations of serum sTREM2 with white matter injury and cognitive heterogeneity in cerebral small vessel disease.

Front Aging Neurosci. 2026;18:1937413. Epub 2026 Sep 21
Authors: Gong Q, Yu X, Chen S, Wan K, Wang Z, Tian B, Zhu X, Zhou X, Sun Z
PubMed: 42835093
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REV-ERBs as regulators of circadian rhythm, neuroinflammation, and glial lipid homeostasis in Alzheimer's disease. A narrative review.

Br J Biomed Sci. 2026;83:16121. Epub 2026 Sep 21
Authors: Shabnam F, Singh M, Amin R, Griffett K
PubMed: 42835017
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Associations between obstructive sleep apnea and Alzheimer's disease-related biomarkers (amyloid-β and tau) in blood and cerebrospinal fluid: a systematic review and meta-analysis.

Front Neurol. 2026;17:1817426. Epub 2026 Sep 21
Authors: Wang J, Che L, Su R, Wang X
PubMed: 42834920
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Novel Therapeutic Strategies in Targeting Alpha Synuclein Dysfunction Pathways for Parkinson's Disease Treatment.

Drug Metab Bioanal. 2026;19(2):95-106.
Authors: Guduru KK, Gundawar R, Eranti B, Turaga K, S SA, Tadimarri P, Pujari HP, Mahasool WT, Arigela PP
PubMed: 42841465
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Natural Products Targeting Alzheimer's Disease via NF-κB Pathway: A Review.

CNS Neurol Disord Drug Targets. 2026;25(8):645-660.
Authors: Hasan F, Thippamma K, Kumar V, Baiseitova A, Ikram M, Shah AB
PubMed: 42841458
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Amyloid, p-tau, neurofilament light, and α-synuclein cerebrospinal fluid biomarkers across Alzheimer's disease, dementia with Lewy bodies, and Parkinson's disease.

Alzheimers Dement (Amst). 2026;18(4):e70498. Epub 2026 Oct 6
Authors: Rizzo M, Teunissen CE, Zetterberg H, Blennow K, Kollmorgen G, Krüger R, Fernandes SB, Aarsland D, Borejko O, Hu M, Chokoshvili D, Vijverberg JE, Lemstra AW, Tijms BM, Petzold GC, Brockmann K, Gasser T, Frisoni GB, Hort J, Nedelska Z, Hopøy AC, Fladby T, Jessen F, Düzel E, Spottke A, Höglinger GU, Mutel S, Chevalier C, Krishnan R, Visser PJ, Vos SJ, EPND consortium
PubMed: 42841041
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Effects of acute sleep deprivation on individuals across different APOE genotypes: a randomized controlled trial protocol.

Front Neurol. 2026;17:1805467. Epub 2026 Sep 22
Authors: Wang HJ, Liu LL, Li YH, Qiu YH, Xia X, Cai YF, Zhang SJ
PubMed: 42840968
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Ionizing radiation and Alzheimer's disease: epidemiology, mechanisms, and eCIRP-mediated tau pathology.

Front Immunol. 2026;17:1961728. Epub 2026 Sep 22
Authors: Brenner M, Sharma A, Wang P
PubMed: 42840967
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Association of apolipoprotein E genotype with cognitive performance: findings from the University of California, Davis Alzheimer's Disease Research Center longitudinal diversity cohort.

Alzheimers Dement (Amst). 2026;18(1):e70304. Epub 2026 Mar 19
Authors: Min E, Gavett B, Sapkota S, Farias ST, Johnson D, Jin LW, Maillard P, Fletcher E, Whitmer RA, DeCarli C
PubMed: 42840901
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Periodontitis and Parkinson's disease: a narrative review of associations, proposed mechanisms, and clinical considerations.

Front Oral Health. 2026;7:1926663. Epub 2026 Sep 22
Authors: Cheng J, Zhang X, Zhou J, Liu L, Feng J, Zhao L
PubMed: 42840879
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Dysregulated mRNA Translation in Alzheimer's Disease: Mechanisms, Therapeutic Opportunities, and Challenges for Clinical Translation.

Clin Interv Aging. 2026;21:626483. Epub 2026 Oct 2
Authors: Li L, Dai F, Liu H, He S, Zhang X, Tao QQ
PubMed: 42840727
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Cognitive reserve and adaptive resilience: a conceptual analysis of a cross-species framework for neuropsychology and cognitive aging.

Front Psychol. 2026;17:1948103. Epub 2026 Sep 22
Authors: Broche-Pérez Y, Díaz-Guerra DD, Hernández-Lugo MC, Ramos-Galarza C
PubMed: 42840685
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Cystatin F as a neuroimmune effector in CNS inflammation and neurodegeneration.

Front Cell Dev Biol. 2026;14:1959727. Epub 2026 Sep 22
Authors: Murray K, Fernandez K, Lane TE
PubMed: 42840580
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Deep cervical lymphovenous reconstruction in Alzheimer's disease: three target-defined interfaces with distinct mechanistic implications.

Front Aging Neurosci. 2026;18:1945322. Epub 2026 Sep 22
Authors: Sun K, Zheng Y, Deng L, Huang W, Lin W
PubMed: 42840558
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Subcortical correlates of sleep in aging and Alzheimer's disease: an in vivo study.

Brain Commun. 2026;8(5):fcag360. Epub 2026 Sep 24
Authors: Pérez-Millan A, Mayà G, Martín-Sobrino I, Peña-González M, Val-Guardiola A, Fernández-Villullas G, Bosch B, Tort-Merino A, Lladó A, Morales-Ruiz M, Walsh CM, Neylan TC, Gaig C, Muñoz-Moreno E, Sánchez-Valle R, Iranzo A, Grinberg LT, Falgàs N
PubMed: 42840459
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Reconsideration of the DTI-ALPS index as a glymphatic surrogate: disease-specific findings in small vessel disease due to cerebral amyloid angiopathy or arteriolosclerosis.

Front Aging Neurosci. 2026;18:1933808. Epub 2026 Sep 22
Authors: Zhou Y, Pan X, Xia Z, Sha Y, Sun G, Han F, Yao M, Zhou L, Tu L, Feng F, Wardlaw JM, Zhu YC, Ni J
PubMed: 42840269
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A computational-first proof-of-concept for dual-function metal chelation and aggregate neutralization in an Aβ42 Drosophila model.

Front Aging Neurosci. 2026;18:1912315. Epub 2026 Sep 22
Authors: Tsai E, Wang Z, Truglio J
PubMed: 42840164
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Epigenetic memory and allostatic integrity: a theoretical integration of the hierarchical-circular model using a longitudinal methylation signature of dementia.

Front Aging Neurosci. 2026;18:1919708. Epub 2026 Sep 22
Authors: Ruesga Mundo S
PubMed: 42840020
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Environmental epigenetic modifiers in neurodegenerative diseases: a systematic review of epigenomic mechanisms and therapeutic targets.

Front Epigenet Epigenom. 2026;4:1833533. Epub 2026 May 28
Authors: Wal P, Mishra S, Pradhan D, Wal A, Purohit D, Nainwal LM, Dhir V, Gasmi A
PubMed: 42839983
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Association between atherogenic dyslipidemia and DBS-derived p-tau217 in older adults: evidence from SHARE DBS data.

Front Aging Neurosci. 2026;18:1948518. Epub 2026 Sep 22
Authors: Wang Z, Liu Y, Sun X, Ling Y
PubMed: 42839948
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A Hierarchical Framework for In Vitro Models of Alzheimer's Disease.

WIREs Mech Dis. 2026;18(5):e70015.
Authors: Balverde-Caballero FB, Pérez-Tur J, Cardona F
PubMed: 42847459
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Association between BrainAGE and Alzheimer's disease biomarkers: Comment.

Alzheimers Dement (Amst). 2026;18(4):e70505. Epub 2026 Oct 7
Authors: Daungsupawong H, Wiwanitkit V
PubMed: 42846866
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Gut-brain immune dysregulation in Parkinson's disease: a hypothesis-forming narrative review of trained immunity.

Front Aging Neurosci. 2026;18:1973833. Epub 2026 Sep 23
Authors: Tang M, Li J, Zhang C, Tu R, Wang S
PubMed: 42846826
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Peroxisomes in Alzheimer's disease: emerging mechanistic insights and therapeutic opportunities.

Front Aging Neurosci. 2026;18:1960320. Epub 2026 Sep 23
Authors: Liu T, Liu Y, Zhang Y, Wang J, Ren Y, Fu S, Han L, Jiang P, Chen J, Li Y, Luo H
PubMed: 42846808
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From retina to brain: retinal dysfunction and dopaminergic neurodegeneration in Drosophila models of Parkinson's disease.

Front Cell Dev Biol. 2026;14:1929128. Epub 2026 Sep 23
Authors: Kadłuczka J, Dymek J, Pyza E, Damulewicz M
PubMed: 42846688
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The Cost of Safety: Balancing Biosafety and Histologic Integrity in Prion Research.

J Exp Neurol. 2026;7(3):120-124.
Authors: Seerley A, Panter AG
PubMed: 42846668
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Computational gait analysis in the 3xTg-AD mouse model: evidence of progressive alterations in locomotor coordination.

Front Aging Neurosci. 2026;18:1879487. Epub 2026 Sep 23
Authors: Castillo Mariqueo L, Valdivia Gallardo M, Giménez Llort L, Taramasco Toro C, Chahuan Moyano L, Robles Cruz D
PubMed: 42846493
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Head-to-head comparison of diffusion imaging markers for cognitive decline and risk of dementia: The population-based Rotterdam Study.

Imaging Neurosci (Camb). 2026;4 Epub 2026 Oct 6
Authors: Rosbergen MT, Wolters FJ, Ikram MA, Vernooij MW
PubMed: 42846338
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Targeting glymphatic-associated pathways for Alzheimer's disease: a review of non-invasive modulation strategies, mechanisms, and emerging evidence.

Front Immunol. 2026;17:1884893. Epub 2026 Sep 23
Authors: Chen J, Zhang W, Liu Q, Zhang Z
PubMed: 42846294
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Blood biomarkers and artificial intelligence: toward precision medicine in Alzheimer's disease.

Front Aging Neurosci. 2026;18:1937244. Epub 2026 Sep 23
Authors: Xu L, Tu J, Zhang J, Zhang C, Sun Y
PubMed: 42846288
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Monospecific antibodies reveal reduction of granulins in frontotemporal dementia caused by GRN mutations.

Mol Neurodegener Adv. 2026;2(1):47. Epub 2026 Oct 6
Authors: Merino P, Araujo LT, Mendsaikhan A, Taylor G, Heath C, Chung M, McEachin ZT, Kukar T
PubMed: 42846257
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Neuro-psycho MMSig: multimodal mechanism enrichment platform for neuropsychiatric disorders.

Front Bioinform. 2026;6:1898607. Epub 2026 Sep 23
Authors: Bharadhwaj VS, Shalaby KS, Guru Rao S, Schultz B, Zhang J, Domingo-Fernández D, Hofmann-Apitius M, Tom Kodamullil A
PubMed: 42846150
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Efficacy of anticoagulation therapy in elderly patients with clinically diagnosed Alzheimer's disease and atrial fibrillation: a clinical outcomes study.

Front Cell Neurosci. 2026;20:1874032. Epub 2026 Sep 23
Authors: Wang X, Yang X, Huang Y, Qian P, Duan H
PubMed: 42846079
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A multimodal machine-learning diagnostic model for Alzheimer's disease: integrating OCTA-derived retinal microvascular features and clinical variables.

Front Aging Neurosci. 2026;18:1911592. Epub 2026 Sep 23
Authors: Zhou Q, Tian Z, Zhao W, Chen X, Liu Y, Wang T, Chen J, Bi Y, Zhang L
PubMed: 42845983
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Exploratory associations between APOE-ε4 carrier status and facial neuromuscular activity in cognitively intact adults: a cross-sectional surface electromyography study.

Front Neurol. 2026;17:1740391. Epub 2026 Sep 23
Authors: Eshghi M, Rong P, Dadgostar M, Shin H, Richburg BD, Barnett NV, Salat DH, Arnold SE, Green JR
PubMed: 42845916
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Alzheimer's disease neuropathological characterization of the dog brain and relationship to biofluid biomarkers and cognitive function.

NPJ Dement. 2026;2(1):88. Epub 2026 Oct 6
Authors: Alsulami A, Bogdani M, MacLean EL, Keene CD, McGrath S, Dog Aging Project Consortium, Latimer CS, Moreno JA
PubMed: 42845905
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