Alzforum - Papers of the Week: 29 May - 4 Jun 2026

Leucine-rich repeat kinase 2 (LRRK2): balancing cellular homeostasis and Parkinson's disease (PD) pathogenesis.

Ann Med. 2026 Dec;58(1):2677288. Epub 2026 Jun 3
Authors: Aolymat I, Abu-Hassan DW, Oleimat AK, Sameer W, Wreikat B, Iqilan T, Al-Momani H, Ali H, Tahtamouni L, Iqsairi M, Albeik M, Debas O
PubMed: 42233523
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Treadmill exercise attenuates neuroinflammation in APP/PS1 mice via gut microbiota remodeling: Evidence from fecal microbiota transplantation.

Life Sci. 2026 Sep 1;400:124500. Epub 2026 May 28
Authors: Yuan S, Lin L, Liu J, Lin Q, Wang S, Wu J, Xu D, Liu Y, Lee JY, Qiu L
PubMed: 42214609
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An LC-MS-guided AI enabled serum molecule-interpretable SERS platform for exploratory metabolomic analysis in Alzheimer's disease.

Anal Chim Acta. 2026 Aug 15;1411:345637. Epub 2026 May 8
Authors: Wang Y, Zhang C, Liu T, Li Q, Guan X, Hu Y, Cao B, Wu X, Zhou Q, Cui F
PubMed: 42218000
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Influence of Cardiometabolic and Alzheimer Disease Genetics on Cognitive-Related Outcomes in a Diverse Population.

Neurology. 2026 Jul 14;107(1):e218163. Epub 2026 Jun 3
Authors: Kim D, McInerney K, Dagli C, Armstrong ND, Cushman M, Bennett A, Blue EE, Sofer T, Sawyer RP, Yuan Y, Crowe M, Judd SE, Olson NC, Irvin MR, Raffield LM
PubMed: 42234953
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Spatial transcriptomics and multi-omics approach to decipher age-related tissue microenvironments and therapeutics in neurodegeneration and aging.

Ageing Res Rev. 2026 Jul;119:103189. Epub 2026 May 28
Authors: Lakra A, Singh N, Vashisth S, Ambasta RK, Kumar P
PubMed: 42214504
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Elucidating the multitarget neuroprotective mechanisms of protocatechuic acid in neurological disorders (Review).

Mol Med Rep. 2026 Jul;34(1) Epub 2026 May 29
Authors: Xue X, Lai Y, Song S, Wu L, Wang L
PubMed: 42212363
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Repurposing GLP-1 receptor agonists and SGLT-2 inhibitors in neurodegeneration and metabolically at-risk populations: Myth or reality? An overview of randomized clinical trials.

Diabetes Res Clin Pract. 2026 Jul;237:113345. Epub 2026 May 27
Authors: Mourtzos MA, Patoulias D, Keklikoglou NM, Karakasis P, de Piñeres VG, Stefanakis K, Rizzo M, Mantzoros CS
PubMed: 42208664
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Time Distributed Classification of Alzheimer's Disease on MRI Scans.

NMR Biomed. 2026 Jul;39(7):e70322.
Authors: Dundar MS, Yilmaz B
PubMed: 42240570
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Intersectional effects of race/ethnicity, sex, and APOE4 on plasma inflammatory profiles in Hispanic and non-Hispanic white adults.

Brain Behav Immun Health. 2026 Jul;54:101256. Epub 2026 May 14
Authors: Contreras JA, Ortega NE, Hayes CA, Pa J, HABS-HD Study Team, HABS-HD MPIs: Sid E O'Bryant, HABS-HD Investigators: Meredith Braskie
PubMed: 42238522
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Longitudinal Change in Blood-Based Biomarkers and the Association With MRI-Measured Neurodegeneration in Cognitively Unimpaired Individuals.

Neurology. 2026 Jun 23;106(12):e218119. Epub 2026 Jun 1
Authors: Trieu C, Dicks E, de Leeuw D, de Wit KD, Van Leeuwenstijn MS, Schlüter LM, Boonkamp L, Barkhof F, Ten Kate M, van de Giessen E, Van Der Flier WM, Van Harten AC, Teunissen CE
PubMed: 42224636
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Associations of Anthropometry Measures Across 35 Years With Late-Life Plasma P-tau217 and Dementia: The HUNT Study.

Neurology. 2026 Jun 23;106(12):e218093. Epub 2026 Jun 2
Authors: Zotcheva E, Strand BH, Sunde A, Deckers K, Aarsland D, Ashton NJ, Zetterberg H, Skirbekk VF, Borda MG, Livingston G, Singh-Manoux A, Selbaek G
PubMed: 42228892
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Andrographolide attenuates microglial senescence in Alzheimer's disease mice by suppressing the STAT3 signaling.

iScience. 2026 Jun 19;29(6):116033. Epub 2026 May 20
Authors: Song H, Yang M, Wu S, Dai Q, Qin W, Xie W, Chen Y, Jiang X, Zhang X, Deng X, Ouyang C, Zhang Y, Liu X, Zhu Y, Huang G
PubMed: 42211120
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Global transcriptional changes across multiple isogenic C9orf72 patient iPSC-derived neurons.

iScience. 2026 Jun 19;29(6):116054. Epub 2026 May 22
Authors: Sreeram A, Baron DM, Brusati A, Stallworth K, Humphrey J, Landers JE
PubMed: 42221822
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High intensity 40 Hz flicker improves amyloid pathology and cognition with autophagy in 3xTg mice.

iScience. 2026 Jun 19;29(6):115994. Epub 2026 May 25
Authors: Gu Z, Fu Y, Huang Y, Zuo C, Song Y, Guo Y, Cao H, Jiang Y, Wang F
PubMed: 42239728
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HaloTag Fusion Enables Dynamic Analysis of Prion Protein Biosynthesis, Turnover, and Misfolding.

Chembiochem. 2026 Jun 15;27(11):e202500831.
Authors: Masone A, Busani E, Chiesa R
PubMed: 42220108
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Expression of Concern.

Biol Psychiatry. 2026 Jun 15;99(12):1166. Epub 2026 Apr 18
Authors:
PubMed: 42209047
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miR-146a is a pleiotropic regulator of motor neuron degeneration.

Proc Natl Acad Sci U S A. 2026 Jun 9;123(23):e2526314123. Epub 2026 Jun 1
Authors: Galloway DA, Patterson HL, Hoye ML, Shen T, Shabsovich M, Schoch KM, Ly CV, Miller TM
PubMed: 42224592
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RNA-centric approaches in amyotrophic lateral sclerosis: prospects for future therapeutics.

Expert Opin Ther Targets. 2026 Jun 8;:1-13. Epub 2026 Jun 8
Authors: La Cognata V, Gentile G, Morello G, Guarnaccia M, Cavallaro S
PubMed: 42215859
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Chitosan-based nanocarriers in Alzheimer's disease therapy: recent developments and future perspectives.

J Drug Target. 2026 Jun 7;:1-18. Epub 2026 Jun 7
Authors: Sharma DK, Prasad CS
PubMed: 42227779
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Reticulophagy limits Alzheimer's disease pathology through FAM134B-dependent APP clearance.

Autophagy. 2026 Jun 7;:1-3. Epub 2026 Jun 7
Authors: Zhang Y, Sun J, Cui Y
PubMed: 42237481
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Blood-based biomarkers for early diagnosis of Alzheimer's disease: a current systematic review of diagnostic accuracy studies.

BMC Neurol. 2026 Jun 5; Epub 2026 Jun 5
Authors: Efe JJ, Anibor E, Pandey P, Sunday OG, Innocent DC, Anyakorah PE, Emmanuel OI
PubMed: 42243744
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Hemispheric lateralization of Tau associations with visual and verbal memory in Alzheimer's disease.

Eur J Nucl Med Mol Imaging. 2026 Jun 5; Epub 2026 Jun 5
Authors: Arias JF, Aumont E, Therriault J, Trudel L, Margherita-Poltronetti N, Thomas E, Bezgin G, Servaes S, Wang YT, Rahmouni N, Macedo A, Quispialaya K, Hosseini SA, Hall B, Kunach P, Jia WL, Chan T, Zheng Y, Woo MS, Mathotaarachchi SS, Vitali P, Pascoal T, Iturria-Medina Y, Montembeault M, Rosa-Neto P
PubMed: 42243535
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CETP Inhibitors: Back With a New Target.

Circ Res. 2026 Jun 5;138(12):e327271. Epub 2026 Jun 4
Authors: Nicholls SJ, Ray KK, Nelson AJ, Kastelein JJ
PubMed: 42241518
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GWAS on short tandem repeats identifies genetic mechanisms in Alzheimer's disease.

Nat Commun. 2026 Jun 4;17(1)
Authors: Gmelin D, Ohlei O, Aslam MM, Junge MP, Parkkinen L, Mullin K, Prokopenko D, Lill CM, Tanzi RE, Dobricic V, Bertram L
PubMed: 42243151
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Multiscale characterization and classification of Alzheimer's disease via integration of brain fingerprint radiomics and graph‑theoretical network metrics.

Neuroradiology. 2026 Jun 4; Epub 2026 Jun 4
Authors: 张宇, 张静, 徐思
PubMed: 42236609
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Human microglial transitions at the Aβ-tau inflection point associate with divergent pathways to dementia and resilience.

Nat Med. 2026 Jun 4; Epub 2026 Jun 4
Authors: Lu A, Chen WT, Dalby M, Sainz Garcia D, Vanheusden M, de Vries LE, van Lieshout V, Martirosyan A, Craessaerts K, Moonen S, Zielonka M, Chrysidou I, Misbaer A, Wolfs L, Pavie B, Swaab D, Thal DR, Huitinga I, Rozemuller A, Rohde SK, Hulsman M, Holstege H, Balice-Gordon R, Plath N, Fiers M, De Strooper B
PubMed: 42243549
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Targeted metabolomics to assess positive effects of empagliflozin in a Parkinson's disease model: focused on the kynurenine pathway and oxidative stress.

Sci Rep. 2026 Jun 4; Epub 2026 Jun 4
Authors: Lénárt I, Horváth O, Molnár K, Bereczki C, Monostori P, Klivényi P, Galla Z
PubMed: 42243212
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Exercise and smoking: health rivals revealing shared protective mechanisms in Parkinson's?

NPJ Parkinsons Dis. 2026 Jun 4; Epub 2026 Jun 4
Authors: Janssen Daalen JM, Schootemeijer S, Oosterhof T, Ripping JM, Bloem BR, Gomperts SN, Schwarzschild MA
PubMed: 42243111
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ATP binding to lysozyme and superfolder GFP amyloid fibrils induces aggregate remodeling and attenuates their cytotoxicity.

Cell Death Discov. 2026 Jun 4; Epub 2026 Jun 4
Authors: Stepanenko OV, Sulatsky MI, Gridasova KG, Mikhailova EV, Sulatskaya AI, Stepanenko OV
PubMed: 42243086
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Deubiquitinases at organelle quality control bottlenecks in neurodegeneration.

Trends Mol Med. 2026 Jun 4; Epub 2026 Jun 4
Authors: Ellerby LM, Ashkenazi A
PubMed: 42243035
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Beyond replacement: Immature neurons as resilience partners in the aging hippocampus.

Cell Stem Cell. 2026 Jun 4;33(6):898-900.
Authors: Farmer WT, Song J
PubMed: 42242186
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Glycoengineered Host-Guest Nanoparticles Potentiate Alzheimer's Disease Therapy via Lesion-Specific Modulation of Tau Pathology.

J Am Chem Soc. 2026 Jun 4; Epub 2026 Jun 4
Authors: Lai Y, Pan J, Gu Y, Zhou C, Yang W, Zhao Q, Zhu Z, Duan Y, Lei L, Fu Y, Zhang H, Fang B, Xu T, Xu Z, Yu H
PubMed: 42241608
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Brain-mapping effort searches for roots of neurodegenerative diseases.

Science. 2026 Jun 4;392(6802):1007. Epub 2026 Jun 4
Authors: Smith JE
PubMed: 42241547
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Synaptic Plasticity Changes in the Somatosensory Cortex During Amyotrophic Lateral Sclerosis Progression and After Swim Training in SOD1-G93A Mice.

Mol Neurobiol. 2026 Jun 4;63(1)
Authors: Saadat A, Jasińska M, Cedro B, Piekarska A, Flis DJ, Ziółkowski W, Pyza E
PubMed: 42240799
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Bobcat-Optimized Hybrid Quantum-Classical Spike-Driven Network for MRI-Based Alzheimer's Stage Prediction.

Int J Neurosci. 2026 Jun 4;:1-30. Epub 2026 Jun 4
Authors: G D, K P, S R, Vijaya Lakshmi TR
PubMed: 42240303
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A Structured Consent Framework for Research of Electroconvulsive Therapy in Advanced Dementia: Consent Process for the ECT-AD Trial.

J ECT. 2026 Jun 4; Epub 2026 Jun 4
Authors: Holzman AL, Forester BP, Wilkins JM, Sanghani SN, Hermida AP, Petrides G, Mueller M, Patrick RE, Nykamp LJ, Gentry MT, Pagali SR, Kung S, Williams SM, Lapid MI
PubMed: 42240217
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Anti-amyloid immunotherapies in Alzheimer's disease: Are future prescribers prepared? Insights of a French national survey.

J Alzheimers Dis. 2026 Jun 4;:13872877261452180. Epub 2026 Jun 4
Authors: Götze K, Auboeuf-Dominguez F, Akroum M, Bellosta CT, Paquet C
PubMed: 42240184
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Fos regulates age-dependent neuroinflammation in VAPBALS.

Dis Model Mech. 2026 Jun 4; Epub 2026 Jun 4
Authors: Kulkarni NP, Thulasidharan A, Soory A, Goel P, Sarkar S, Kelkar V, Ratnaparkhi GS
PubMed: 42237814
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Neuroprotective Effects of RNS60 in TDP-43 Pathology-Associated Amyotrophic Lateral Sclerosis.

Muscle Nerve. 2026 Jun 4; Epub 2026 Jun 4
Authors: Vesevick DR, Ghosh S, Kalmes A, Ozdinler PH, Gautam M
PubMed: 42237658
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Hierarchical organization of tau topography across the Alzheimer's disease continuum integrates amyloid, connectome, and intrinsic molecular vulnerability.

Commun Biol. 2026 Jun 3; Epub 2026 Jun 3
Authors: Zeng ZM, Han SS, Liu Q, Zeng CD, Jia X, Bi J, Liu LC, Gao TA, Liang L, Cheng FX
PubMed: 42230978
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Early Gut Microbiome Alterations in Mild Cognitive Impairment Reflect Changes in Alzheimer Disease.

Alzheimer Dis Assoc Disord. 2026 Jun 3; Epub 2026 Jun 3
Authors: Brandt E, Koivisto A, Pereira P, Mustanoja E, Auvinen P, Saari T, Rusanen M, Leinonen V, Scheperjans F, Kärkkäinen V
PubMed: 42228448
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Consensus meta-analysis of genome-wide association studies for Alzheimer's disease and related dementias.

Nat Genet. 2026 Jun 3; Epub 2026 Jun 3
Authors: EADB, EADI, Bonn, ADGC, CHARGE, FinnGen, GERAD, GR@ACE/DEGESCO, PGC-ALZ
PubMed: 42237039
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AETA peptide contributes to Alzheimer's disease signature of synapse dysfunction.

Acta Neuropathol. 2026 Jun 3;151(1)
Authors: Dunot J, Gandin C, Truchi M, Pirro G, Moreno S, Launay A, Azoulay B, Landra H, Yishan SM, Buée L, Lebrigand K, Pousinha PA, Blum D, Mari B, Bethus I, Willem M, Marie H
PubMed: 42237024
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A human telomerase reverse transcriptase-derived peptide GV1001 rescues neurodegeneration in a mouse model of Alzheimer disease.

Exp Mol Med. 2026 Jun 3; Epub 2026 Jun 3
Authors: Lee Y, Nam H, Lee JW, Ko YJ, Kim EJ, Ha S, Kim N, Koo JW, Son T, Kim S, Yu SW
PubMed: 42236894
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Targeting mitophagy for neuroprotection: mechanisms and therapeutic opportunities.

NPJ Aging. 2026 Jun 3; Epub 2026 Jun 3
Authors: Yang J, Li J, Hou X, Zheng Y, Zhao Z, Zhou T, Jing T, Kong J, Zhang G, Guo Y
PubMed: 42236747
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In silico investigation of thiazole-semicarbazide hybrids as dual GSK-3β/Tau inhibitors for Alzheimer's disease.

Sci Rep. 2026 Jun 3; Epub 2026 Jun 3
Authors: Kumar D, Walhekar V, Shenoy KM, Kini SG
PubMed: 42236499
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Corrigendum to "Collective methodological emission assay of Thioflavin T for qualitative α-synuclein fibril structures discrimination" [Int. J. Biol. Macromol., volume 335, part 1, 2026, 148994].

Int J Biol Macromol. 2026 Jun 3;:152734. Epub 2026 Jun 3
Authors: Szwachta G, Sulskis D, Konopka A, Jałonicka E, Struniawski K, Mikalauskaite K, Sakalauskas A, Kozera R, Smirnovas V, Stsiapura V, Ziaunys M, Hanczyc P
PubMed: 42236422
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Temporal pattern of dementia with lewy bodies diagnostic labels around electroconvulsive therapy: A nationwide claims-based study.

Int Psychogeriatr. 2026 Jun 3;:100224. Epub 2026 Jun 3
Authors: Hata M, Miyazaki Y, Takahashi S, Ikeda M
PubMed: 42236351
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Neuronal Surface and Intracellular Antibodies in Mild Cognitive Impairment Due to Alzheimer Disease: Preserved Brain Metabolism on 18F-FDG-PET.

AJNR Am J Neuroradiol. 2026 Jun 3;47(6):1664-1671.
Authors: Luan H, Chen Z, Han X, Wang P, Sun W, Gong J, Li S, Li R, Xu C, Wen B, Lv S, Yan S, Wei C
PubMed: 42235964
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A cytoplasmic turn in TDP-43 toxicity.

Neuron. 2026 Jun 3;114(11):1879-1880.
Authors: Donnelly CJ
PubMed: 42235485
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[Herpes zoster, vaccination, and dementia risk: An unexpected opportunity for Primary Care].

Semergen. 2026 Jun 3;52(6):102758. Epub 2026 Jun 3
Authors: Alcántara Montero A, Mena Barra MP
PubMed: 42235304
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Psychometric properties of the Norwegian CAMDEX-DS-II and CAMCOG-DS-II for dementia assessment in adults with Down syndrome: A national multi-site clinical study.

Res Dev Disabil. 2026 Jun 3;175:105320. Epub 2026 Jun 3
Authors: Larsen FK, Medbøen IT, Strydom A, Selbæk G, Strand BH, Langballe EM
PubMed: 42235213
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Effects of fasudil on disease spreading in ALS - A MUNIX-based post-hoc analysis of the ROCK-ALS trial.

Neurotherapeutics. 2026 Jun 3;23(4):e00936. Epub 2026 Jun 3
Authors: Wolff AW, Leha A, Koch JC, Demleitner AF, Neuwirth C, Friede T, Weber M, Lingor P
PubMed: 42235092
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Cryptic splicing in synaptic and membrane excitability genes links TDP-43 loss to neuronal dysfunction.

Sci Transl Med. 2026 Jun 3;18(852):eaeb8517. Epub 2026 Jun 3
Authors: Guo C, Chen K, Vatsavayai S, Akiyama T, Liu C, Zeng Y, Sianto O, Yang E, Bombosch J, Powell R, Zhen S, Mekhoubad S, Morrie RD, Miller G, Ilic D, Boll M, Parnell E, Penzes P, Lipstein N, Green EM, Petrucelli L, Seeley WW, Gitler AD
PubMed: 42234776
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Soluble TREM1 Contributes to Aging-Related Neurodegeneration via ROBO2/ERK Pathway.

Mol Neurobiol. 2026 Jun 3;63(1)
Authors: Qi JW, He XY, Gu YC, Luo ZJ, Duan R, Zhang YD, Xie Y, Jiang T
PubMed: 42234329
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Biological pathways related to mirna-125a-5p in behavioral variant of frontotemporal dementia.

Mol Biol Rep. 2026 Jun 3;53(1)
Authors: Pereira JD, Silva LM, Ozawa M, Tosatti JA, Lima SP, Silva IR, Jeunon VR, das Graças Carvalho M, de Paula França Resende E, de Souza LC, Caramelli P, Gomes KB
PubMed: 42234230
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Circular RNA circTrpc6-induced tau phosphorylation contributes to neuronal injury and cognitive decline via miR-485-5p/eIF4E axis in senescence-accelerated mouse prone 8 mice.

Cell Biol Toxicol. 2026 Jun 3; Epub 2026 Jun 3
Authors: Huang JL, Yan QQ, Guo YB, Du YX, Liu LL, Sun XJ, Yu C, Wu DP
PubMed: 42234179
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The link between dental care use and incident diabetes, cancer, and Alzheimer disease among older Americans: the health and retirement study.

Saudi Dent J. 2026 Jun 3;38(6)
Authors: Agheshteh Sabzevar N, Musaie F, Ostovar Ravari A, Gharehdaghi N, Kianfar K, Ahmadi S, Irannejadrankouhi S, Fazel T, Sadeghi S, Yarahmadi D, Malekpour H, Deravi N
PubMed: 42234065
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An Activator of Tailless' Repressor Function Stimulates Anti-Neurodegenerative Gene Expression.

J Med Chem. 2026 Jun 3; Epub 2026 Jun 3
Authors: Hank EC, Busch R, López-García Ú, Kasch T, Knümann L, Morozov V, Höfner G, Marschner JA, Merk D
PubMed: 42233775
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Fluorescence spectroscopy and machine learning methods for detection of Alzheimer's disease from circulating white blood cells.

J Alzheimers Dis. 2026 Jun 3;:13872877261453512. Epub 2026 Jun 3
Authors: Tsutsui S, Stepanchuk AA, Stys JP, Black SA, Templeton GW, Greiner R, Stys PK
PubMed: 42231859
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A multimodal evaluation of transcranial photobiomodulation in mild cognitive impairment: Cognitive, metabolic, and neuroimaging outcomes of a pilot randomized controlled trial.

J Alzheimers Dis. 2026 Jun 3;:13872877261453911. Epub 2026 Jun 3
Authors: Rashidi-Ranjbar N, Churchill NW, Jerkic M, Zomorrodi R, Rotstein O, Schneider R, Andreazza AC, Rajji TK, Graham SJ, Munoz DG, Fornazzari L, Lim L, Norris M, Schweizer TA, Fischer CE
PubMed: 42231857
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Secoisolariciresinol diglucoside ameliorates Alzheimer-like lesions by increasing MKP-1.

J Alzheimers Dis. 2026 Jun 3;:13872877261450557. Epub 2026 Jun 3
Authors: Chen M, Xie Q, Yi F, Ma J, Lu S, Ouyang H, Qin Y, Yang S, Wei W, Liu Y
PubMed: 42231856
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Connected-speech digital biomarkers for monitoring transcranial pulse stimulation in Alzheimer's disease: A pilot study.

J Alzheimers Dis. 2026 Jun 3;:13872877261456294. Epub 2026 Jun 3
Authors: Wiechmann D, Günes A, Kerz E, Qiao Y, Köhne M, Sprick U
PubMed: 42231842
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Persistent PirB cleavage drives Golgi-directed trafficking deficits underlying neurodegeneration.

Transl Neurodegener. 2026 Jun 3;15(1)
Authors: Han WB, Liu XD, Tang CF, Zheng J, Xu TL, Xu NJ, Sun S
PubMed: 42231420
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Exercise Lowers Hepatic Amyloid β Concentrations in Alzheimer's Rodent Model.

Med Sci Sports Exerc. 2026 Jun 3; Epub 2026 Jun 3
Authors: Zarnashan A, Fazli F, Talebi V, Patel DI
PubMed: 42231099
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Microglial OTUD6A promotes neuroinflammation and Alzheimer's disease pathogenesis by deubiquitinating C/EBPβ.

Pharmacol Res. 2026 Jun 3;230:108280. Epub 2026 Jun 3
Authors: She L, Li M, Chen F, Wu X, Zhang J, Jiang W, Sun Z, Li L, Ren J, Chen D, Zhao X, Liang G
PubMed: 42242445
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Alzheimer's disease and cerebrovascular biomarkers in relation to odor identification in a naturalistic clinical cohort.

Alzheimers Res Ther. 2026 Jun 3;18(1)
Authors: Oltra J, Ištvánfyová Z, Kalpouzos G, Ekström I, Hagman G, Kivipelto M, Laukka EJ
PubMed: 42237406
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Insulin resistance alters cortical inhibitory neurons and microglia to exacerbate Alzheimer's knock-in mouse phenotypes.

Mol Neurodegener. 2026 Jun 3; Epub 2026 Jun 3
Authors: Nicholson L, Tang SJ, Karra T, Abouelatta H, Strittmatter SM
PubMed: 42237401
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Neuronal overexpression of Nrf2 reduces dystrophic neurites in 5XFAD Alzheimer's disease model mice.

Alzheimers Res Ther. 2026 Jun 3; Epub 2026 Jun 3
Authors: Sadleir KR, Gomez KP, Chandra S, Ley ML, Khatri AW, Guo J, Xue Y, Cepko CL, Vassar R
PubMed: 42237182
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Plasma Amyloid Beta and Tau Associations with Cerebral Amyloid Angiopathy Presence and Severity.

Ann Neurol. 2026 Jun 3; Epub 2026 Jun 3
Authors: Bax F, Liu L, van Harten TW, Gokcal E, Horn MJ, Warren A, Saba A, Shirzadi Z, DiPucchio ZY, Schwab KM, Gurol ME, Viswanathan A, Chhatwal JP, Greenberg SM
PubMed: 42237156
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BIN1 gain-of-function in the presynaptic compartment leads to isoform-specific synaptotoxicity.

Alzheimers Res Ther. 2026 Jun 3; Epub 2026 Jun 3
Authors: Lambert E, Gelle C, Leclerc V, Freire-Regatillo A, Liefooghe L, Barois N, Malfoi T, Hermant X, Demiautte F, Gallienne I, Lafont F, Amouyel P, Blary K, Kuenen S, Najdek C, Verstreken P, Siedlecki-Wullich D, Yger P, Lambert JC, Kilinc D, Dourlen P
PubMed: 42237143
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Lipoprotein(a) and risk of dementia: A propensity score-matched real-world analysis from a global federated research network.

Eur J Intern Med. 2026 Jun 2;:106984. Epub 2026 Jun 2
Authors: Rossi M, Tartaglia E, Askarinejad A, Serio L, Ferri C, Bucci T, Lip GY
PubMed: 42225501
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Improvements in Cogstate Test Performance Depend on Number and Frequency of Prior Tests: Evidence from a Randomized Follow-Up Design.

Alzheimer Dis Assoc Disord. 2026 Jun 2; Epub 2026 Jun 2
Authors: Murchland AR, Chen R, Blacker D, Kang JH, Glymour MM, Haneuse S
PubMed: 42224199
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DREAM repressive activity links somatic mutation, lifespan and disease.

Nat Aging. 2026 Jun 2; Epub 2026 Jun 2
Authors: Koch Z, Nandi SP, Licon K, Bujarrabal-Dueso A, Meyer DH, Saeed S, Perampalam P, Dick FA, Schumacher B, Alexandrov LB, Ideker T
PubMed: 42230995
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Sex-specific regulation of angiogenin in Alzheimer's disease.

Mol Psychiatry. 2026 Jun 2; Epub 2026 Jun 2
Authors: Jörg M, Walz L, Nathal S, Kristen M, Lietz C, Müller M, Nguyen VT, Ruffini N, Winz ML, Gerber S, Endres K, Helm M, Friedland K
PubMed: 42230965
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Exploring automated plasma phospho-tau217 assays for the diagnosis of Down syndrome-related Alzheimer's disease.

Commun Med (Lond). 2026 Jun 2; Epub 2026 Jun 2
Authors: Schlachetzki Z, Langford O, Zammit MD, Donohue MC, Zhou X, Sukreet S, Abdel-Latif S, Braunstein JB, Rissman RA, Rafii MS
PubMed: 42230953
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Brain pathology in relation to somatic diseases: Exploring the body-brain crosstalk.

J Intern Med. 2026 Jun 2; Epub 2026 Jun 2
Authors: Grande G, Valletta M, Gasparini F, Vetrano DL, Canevelli M, Bacci JR, Qiu C, Marengoni A, Blasi MT, Xu H, Fratiglioni L, Mielke MM
PubMed: 42230841
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Gain-of-function Modulation of TREM2 and its Impact on Amyloid-β and Tau Pathologies in Alzheimer's Disease: A Systematic Review and Meta-analysis of Animal Studies.

Mol Neurobiol. 2026 Jun 2;63(1)
Authors: Liao Y, Ye S, Zhao L, Zhou M, Wen Y, Zhu Y, Huang J, Zhang L, Zhang X, Guo P, Xie Y
PubMed: 42230432
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The test-retest reproducibility of [11C]PK11195 positron emission tomography using Biograph Vision Quadra scanner.

EJNMMI Res. 2026 Jun 2; Epub 2026 Jun 2
Authors: Sjöros T, Matilainen M, Saunavaara V, Wahlroos S, Rajander J, Koivumäki M, Honkonen E, Luoma A, Airas L
PubMed: 42230367
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Serum neurofilaments for motoneuron and dementia diseases: a German multicenter cohort study.

J Neurol. 2026 Jun 2;273(6)
Authors: Barba L, Steinacker P, Halbgebauer S, Oeckl P, Landwehrmeyer B, Weishaupt J, Verde F, Ticozzi N, Silani V, Levin J, Schönecker S, Kornhuber J, Prudlo J, Schroeter ML, Fassbender K, Fliessbach K, Diehl-Schmid J, Jahn H, Lauer M, Dorst J, Rosenbohm A, Abu-Rumeileh S, Anderl-Straub S, Söntgerth M, Böhm F, Wiltfang J, Otto M
PubMed: 42230361
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Sporadic Creutzfeldt-Jakob disease: a multidimensional review from epidemiology to treatment and prognosis.

J Neurol. 2026 Jun 2;273(6)
Authors: Gao Y, Li P
PubMed: 42230352
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Cerebellar rTMS ameliorates cognitive impairment in Alzheimer's disease: A randomized trial.

Brain Stimul. 2026 Jun 2;19(4):103138. Epub 2026 Jun 2
Authors: Wang D, Fan J, Wang T, Tang F, Yao Q, Ye X, Qi X, Tian M, Lin X, Shi J
PubMed: 42229579
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Lipid Droplet-Accumulating Microglia as a Therapeutic Node in Neurodegenerative Disease.

ACS Chem Neurosci. 2026 Jun 2; Epub 2026 Jun 2
Authors: Guo S, Zhang Q, Guo R, Fu L, Zhu H, Zhang Q
PubMed: 42228839
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A Reproducible Supermicrosurgical Model of Cervical Lymphatic-Venous Anastomosis in Transgenic Alzheimer.

J Craniofac Surg. 2026 Jun 2; Epub 2026 Jun 2
Authors: Jin L, Fang R, Wu J, Xie Q, Xiao M, Wang J, Yang X, Kueckelhaus M, Lu H
PubMed: 42228430
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Decoding neuroinflammation: the critical role of NLRP3 inflammasome in Alzheimer's disease.

Inflammopharmacology. 2026 Jun 2; Epub 2026 Jun 2
Authors: Chaudhary B, Kumari S, Sharma P, Dhapola R, Paidlewar M, Vellingiri B, Medhi B, HariKrishnaReddy D
PubMed: 42228338
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FUS modulates R-loops by functionally interacting with RNase H1.

Hum Cell. 2026 Jun 2;39(6)
Authors: Dey A, Das R, Uppal S
PubMed: 42228326
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Integrative Transcriptomic, Network, and Machine Learning Analyses Identify Genistein and Resveratrol-Associated Therapeutic Targets in Alzheimer's Disease.

Mol Neurobiol. 2026 Jun 2;63(1)
Authors: Isıyel M, Ceylan H, Demir Y
PubMed: 42228255
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A Biomarker Out of Context: Understanding High p-tau217 in the Developing Brain.

Mol Neurobiol. 2026 Jun 2;63(1)
Authors: Pal A, Yadav H, Yadav D, Goel F, Rajput MS
PubMed: 42228248
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Ultrasound-induced blood-brain barrier opening in Alzheimer's disease: a systematic review of clinical studies.

Aging Clin Exp Res. 2026 Jun 2; Epub 2026 Jun 2
Authors: Niknam N, Songhori N, Nekahi N, Kavian M, Khosravi F, Fard AM, Moshiri Y, Haghshenas N, Sadegh MH, Torabi P
PubMed: 42228053
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Mediating effect of Life's Essential 8 score in the associations of SES mobility with cognitive function, dementia incidence and neuroimaging markers.

Aging Ment Health. 2026 Jun 2;:1-14. Epub 2026 Jun 2
Authors: Liu G, Hong C, Huang Y, Liu Y, Guan B, Jin X, Dai W, Luo Y
PubMed: 42227878
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Site-Specific Raman Probes Reveal Droplet Aging and Residue-Level Fibril Polymorphism in TDP-43CTD.

J Am Chem Soc. 2026 Jun 2; Epub 2026 Jun 2
Authors: Watson MD, Lee JC
PubMed: 42227825
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Global research landscape of oligodendrocytes in Alzheimer's disease: A bibliometric and knowledge-mapping analysis from 1990 to 2025.

J Alzheimers Dis. 2026 Jun 2;:13872877261456313. Epub 2026 Jun 2
Authors: Zhang J, Teng Y, Li Y, Zhang M
PubMed: 42227745
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The Mind and Movement clinic: developing a new integrated cognitive-neuropsychiatric service for Lewy body dementia.

Ir J Psychol Med. 2026 Jun 2;:1-11. Epub 2026 Jun 2
Authors: Alexopoulos P, Frau L, Carroll E, Keane O, Panse A, Dignam H, Bradley D, Mullen A, Leroi I
PubMed: 42227417
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Cognitive and motor reserve in Parkinson's disease: Two sides of the same coin?

J Neuropsychol. 2026 Jun 2; Epub 2026 Jun 2
Authors: Anzuino I, Di Tella S, Tondinelli A, Scopetani Testa C, Petracca M, Lo Monaco MR, Bentivoglio AR, Silveri MC
PubMed: 42227225
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Speech-based machine learning for detecting neuropsychiatric symptoms in Alzheimer's disease.

J Alzheimers Dis. 2026 Jun 2;:13872877261456293. Epub 2026 Jun 2
Authors: Chen Y, Huang H, He Y, Chen S, Tan Y, Song J, Chen L, Wang X, Lü Y, Yu W
PubMed: 42227197
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Combining plasma biomarkers and cognitive challenge tests enhances prediction of functional trajectories of decline among older adults with cognitive impairment.

J Alzheimers Dis. 2026 Jun 2;:13872877261453396. Epub 2026 Jun 2
Authors: Diane Zheng D, Curiel Cid RE, Ortega A, Crenshaw KH, Crocco EA, Vaillancourt D, Armstrong MJ, Wang WE, Asken B, Adjouadi M, Marsiske M, Rosselli M, Barker WW, Smith G, Dekosky ST, Duara R, Loewenstein DA
PubMed: 42227192
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Gut-brain axis crosstalk in patients with Alzheimer's disease and high body mass index: Gut dysbiosis, blood-brain barrier disruption, and neuroinflammation.

J Alzheimers Dis. 2026 Jun 2;:13872877261441465. Epub 2026 Jun 2
Authors: Li J, Lian T, Guo P, Li J, Qi J, Luo D, Meng Y, He M, Zheng Z, Yue H, Liu Z, Zhang F, Wang R, Zhang W, Zhang W
PubMed: 42227185
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Naming performance in bilinguals with Alzheimer's disease and mild cognitive impairment.

J Alzheimers Dis. 2026 Jun 2;:13872877261452694. Epub 2026 Jun 2
Authors: Sainz-Pardo M, Hernández M, Suades A, Juncadella M, Ortiz-Gil J, Ugas L, Sala I, Lleó A, Calabria M
PubMed: 42227174
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Integrative genomic and transcriptomic analysis identifies microglia-expressed genes with causal links to Alzheimer's disease risk.

J Alzheimers Dis. 2026 Jun 2;:13872877261452242. Epub 2026 Jun 2
Authors: Zhao Y, Liu C, Yv K, Wang N, Li Z
PubMed: 42227173
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Overinvestment in ultra‑rare APOE variants and highly speculative apoE-inhibitor docking risks undermining translational progress in sporadic Alzheimer's disease.

J Biomol Struct Dyn. 2026 Jun 2;:1-9. Epub 2026 Jun 2
Authors: Gillet JN
PubMed: 42227120
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The gut-brain axis in Alzheimer's and Parkinson's diseases: a systematic review of microbiota-derived biomarkers and novel therapeutic approaches.

J Clin Exp Neuropsychol. 2026 Jun 2;:1-16. Epub 2026 Jun 2
Authors: Singh VK, Gupta P, Jain SK, Matreja PS
PubMed: 42227044
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Effects of apolipoprotein E ε4 on amyloid deposition and relative cerebral perfusion in cognitively normal individuals: a dual-phase 18F-florbetaben PET study.

Nucl Med Commun. 2026 Jun 2; Epub 2026 Jun 2
Authors: Kim JY, Kim D, Kim GH, Yoon HJ
PubMed: 42226517
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Single-trial assessment of gamma-frequency brain oscillations and their modulation using transcranial alternating current stimulation (tACS).

Brain Stimul. 2026 Jun 2;19(4):103139. Epub 2026 Jun 2
Authors: Jonany V, Haslacher D, Robinson SE, Sander T, Zerfowski J, Peekhaus N, Krüger P, Soekadar SR
PubMed: 42235884
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Robust end-to-end stratification of amyotrophic lateral sclerosis patients via recurrent variational autoencoder and consensus clustering.

J Biomed Inform. 2026 Jun 2;180:105059. Epub 2026 Jun 2
Authors: De Mori Bajolin F, Tavazzi E, Bianchi AM, Mendez MO
PubMed: 42235808
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Phytochemical engineered quantum dots as potential therapy to counter alpha synuclein aggregation in Parkinson's disease.

Neurochem Int. 2026 Jun 2;198:106194. Epub 2026 Jun 2
Authors: Shashwat P, Kirthi AV, Selvaraj M, Karnwal A, Dutta J
PubMed: 42235756
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Broussochalcone A alleviates cognitive impairment in scopolamine-induced mice as a potent β-amyloid aggregation inhibitor and changes blood and brain metabolite profiles.

J Ethnopharmacol. 2026 Jun 2;370:121958. Epub 2026 Jun 2
Authors: Oh JM, Jeong WK, Son HJ, Kwon YJ, Kim SY, Oh TW, Ji M, Baek M, Shin WH, Kim HJ, Choi B, Kim SH, Paik MJ, Kim H
PubMed: 42235718
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Stage-specific hippocampal network degeneration links amyloid-cognition relationships: Right subiculum as structural substrate for memory maintenance and biomarker in amyloid-positive mild cognitive impairment.

Neuroimage. 2026 Jun 2;:122022. Epub 2026 Jun 2
Authors: Wang Z, Huang L, Guan Y, Pan J, Yuan C, Xie F, Huang CC, Guo Q
PubMed: 42235661
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Pramipexole promotes CD8+ regulatory T cell-dependent neuroprotection in Parkinson's disease patients.

Brain Behav Immun. 2026 Jun 2;137:106840. Epub 2026 Jun 2
Authors: Gallegos-Altamirano E, Castillo-Arellano J, Pérez Figueroa E, Guevara-Salinas A, González-Vilchis E, Morales-Ruiz V, Álvarez-Luquin D, Rodríguez-Violante M, Ichikawa-Escamilla E, Regalado-Mustafa AY, Romero-Rodríguez D, Martínez-Martínez E, Velasco I, Adalid-Peralta L
PubMed: 42235653
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Exosome mimetic nanoparticles for siRNA based targeting of α-synuclein and neuroinflammation in Parkinson's disease.

J Pharm Pharmacol. 2026 Jun 2;78(6)
Authors: Shamim S, Singh AP, Sharma H, Gohri S, Taumar D, Chaudhary V
PubMed: 42234812
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Polymeric lysosome-targeting chimeras for extracellular α-synuclein degradation in Parkinson's disease.

Acta Neuropathol Commun. 2026 Jun 2; Epub 2026 Jun 2
Authors: Bhattacharya A, Almohaimeed HM, Aggad WS, Almars AI, Altowaijri OM, Waggas HA, Bauthman NM, Mohammedsaleh ZM, ALMatrafi TA, Saleh FM, Uti DE
PubMed: 42231395
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[Advances in Anti-Dementia Therapies in Older Adults].

Dtsch Med Wochenschr. 2026 Jun;151(12):606-611. Epub 2026 May 29
Authors: Schnieder M, von Arnim C
PubMed: 42214359
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5-Hydroxytryptamine Distribution Alteration in Both Neuron and Synapse of Tg(SOD1*G93A)1gur Mice: A Potential Intervention Candidate Strategy for Amyotrophic Lateral Sclerosis.

CNS Neurosci Ther. 2026 Jun;32(6):e70946.
Authors: Zhou L, Li M, Dai Q, Liu X, Li C, Jiao H, Pan H, Xu R
PubMed: 42212756
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Improving the Delivery of Brain Health Care to All. Keeping our Eye on the Main Prize in an Era of Emerging Anti-Amyloid Therapies.

Can Geriatr J. 2026 Jun;29(2):144-146. Epub 2026 Jun 3
Authors: Montero-Odasso M, Lee L, Hogan DB
PubMed: 42211445
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AlzStack: Forecasting early-onset Alzheimer's with an explainable AI system using multiple data balancing techniques.

Glob Epidemiol. 2026 Jun;11:100261. Epub 2026 May 5
Authors: Modali VA, Pavanya M, Arjunan V, Cenitta D, Sampathila N, Kamath R, Chadaga K
PubMed: 42211344
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Transposable element small RNAs and large RNAs in aging brains and implications in Huntington's and Parkinson's disease.

Genome Res. 2026 Jun 1;36(6):1125-1140.
Authors: Dayama G, Lee JR, Gupta S, Brion C, Connizzo BK, Labadorf AT, Myers RH, Lau NC
PubMed: 42209156
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Evidence for direct and sleep-moderated relationships between aquaporin-4 genetic variants and Alzheimer's disease phenotypes.

Alzheimers Dement. 2026 Jun;22(6):e71516.
Authors: Porter T, Armstrong AM, O'Brien EK, Doré V, Bourgeat P, Turner M, Maruff P, Rowe CC, Brown BM, Villemagne VL, Rainey-Smith SR, Laws SM, AIBL Research Group
PubMed: 42216479
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Sleep-like slow waves during resting-state: A promising EEG biomarker of amyloid and neurodegeneration in preclinical Alzheimer's disease.

Alzheimers Dement. 2026 Jun;22(6):e71514.
Authors: Champetier P, Albero C, Raposo Pereira F, Herzog R, Chaumon M, Houot M, Locatelli M, Kas A, Habert MO, Teichmann M, Epelbaum S, Arnulf I, Oudiette D, Andrillon T, INSIGHT‐preAD group
PubMed: 42216470
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Integration of TSPO PET and fluid biomarkers to assess neuroinflammation in Parkinson's disease.

Eur J Nucl Med Mol Imaging. 2026 Jun 1; Epub 2026 Jun 1
Authors: Yeh SH, Yu TH, Liu CJ, Fan SP, Chen PS, Li CH, Cheng MF, Lin CH
PubMed: 42219425
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Early and sustained Intervention with YKB Modulates the Cerebro-Retinal-Synaptic Network to Ameliorate Memory Deficits in Alzheimer's Disease.

Brain Res. 2026 Jun 1;1888:150396. Epub 2026 Jun 1
Authors: Liu Y, Li L, Pu J, Xiong Y, Feng T, Liu Z, Zhou C, Xu H, Sayami N, Yang J, Zhou H, Gan P
PubMed: 42219140
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GPR139-mediated cholinergic circuit from the medial septum to the ventral hippocampal CA3 modulates cognitive impairment in Alzheimer's disease.

Neuropharmacology. 2026 Jun 1;298:111043. Epub 2026 Jun 1
Authors: Li H, Hou X, Qin C, Li X, Wu X, Mu R
PubMed: 42218995
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Corrigendum to "Pathophysiological association between periodontal disease and Alzheimer's disease: Importance of periodontal health in the elderly" [Volume 63, Issue 4, 2021, Pages 351-359].

J Oral Biosci. 2026 Jun;68(3):100765. Epub 2026 Feb 26
Authors: Desta N
PubMed: 42218008
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The Role of Apathy in the Association Between Depressive Symptoms and Subjective Cognitive Complaints.

Int J Geriatr Psychiatry. 2026 Jun;41(6):e70223.
Authors: Barker MS, Joyce JL, Waltrip L, Chapman S, Gu Y, Sunderaraman P, Huey ED, Cosentino SA
PubMed: 42217241
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Targeting MAPK-dependent pathways to modulate reactive astrocyte pathology in neurodegeneration.

Commun Biol. 2026 Jun 1; Epub 2026 Jun 1
Authors: Pervaiz I, Blazier AS, Nyarko-Danquah I, Wesseling H, Ramos A, Woodworth L, Taksir TV, Ryan SK, Wirak G, Zhao Z, Hammond TR, Morel C, Bangari DS, Ofengeim D, Rapino F, Hagan N
PubMed: 42225893
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Longitudinal cognitive assessment using the Cumulus NeuLogiq platform in amyotrophic lateral sclerosis and frontotemporal dementia.

Sci Rep. 2026 Jun 1; Epub 2026 Jun 1
Authors: Costello E, Kiyui K, Brennan C, Obain NN, Leonard S, Heverin M, Barbey F, Dyer J, Rueda-Delgado L, Diggin S, Tunbridge E, Marston H, Lai RY, Hargreaves R, Shinobu L, Nguyen V, Hake AM, Dawson G, Latzman R, Buick A, Murphy B, Hardiman O, Pender N
PubMed: 42225765
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Effect of acute ischemic stroke in 3xTg-AD mouse model of Alzheimer's disease.

Sci Rep. 2026 Jun 1; Epub 2026 Jun 1
Authors: Yadav SK, Srivastava R, Yadawa AK, Gamiotea-Turro D, Verma R
PubMed: 42225737
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Dopamine-endocannabinoid crosstalk drives exercise-induced bidirectional plasticity in Parkinson's disease.

NPJ Parkinsons Dis. 2026 Jun 1; Epub 2026 Jun 1
Authors: Campanelli F, Marino G, Natale G, De Carluccio M, Rodriguez TN, Smeyne M, Smeyne RJ, Ghiglieri V, Calabresi P
PubMed: 42225705
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Nonconjugated Alkyl Chains in Ionic Molecular Rotor Fluorophores: An Effective Modulating Moiety for Amyloid-β Probes.

Anal Chem. 2026 Jun 1; Epub 2026 Jun 1
Authors: Zhang Z, Yi J, Lin Z, Wang Z, Wang YL, Du X, Qin T
PubMed: 42225417
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Apathy in dementia with Lewy bodies: Frequency, correlates, and impact on patient and caregiver experiences.

Parkinsonism Relat Disord. 2026 Jun 1;149:108373. Epub 2026 Jun 1
Authors: Barnes AL, Martinez-Nunez AE, Wang T, Li Z, Pontone GM, Armstrong MJ
PubMed: 42224876
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Identification of Functional lncRNAs in Alzheimer Disease by Integrative Analysis of lncRNA-mRNA Network Based on Competing Endogenous RNA Mechanism.

Alzheimer Dis Assoc Disord. 2026 Jun 1; Epub 2026 Jun 1
Authors: Su Y, Ren H, Huang S, Hao Y
PubMed: 42224107
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Variability in Clinical Performance of the FDA-Cleared Lumipulse P-Tau217/β-Amyloid 1-42 Plasma Ratio.

JAMA Neurol. 2026 Jun 1; Epub 2026 Jun 1
Authors: Algeciras-Schimnich A, Bornhorst JA, Figdore DJ, Rea Reyes RE, Ashrafzadeh-Kian S, Wilson R, Burkett BJ, Johnson DR, Botha H, McCarter SJ, Day GS, Graff-Radford J, Ramanan VK, Jack CR Jr, Johnson SC, Zetterberg H, Petersen RC
PubMed: 42223932
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Taliglucerase Alfa Reduces Amyloid-β Burden by Restoring Autophagic Pathways in a Neuronal Model of Alzheimer's Disease.

Neurochem Res. 2026 Jun 1;51(3)
Authors: Özkurt Ç, Köse S, Karasu Ç, Kortholt A, Kelicen-Uğur P
PubMed: 42223785
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APOE genotype, cardiovascular risk, and incident dementia in the Norwegian HUNT study.

Eur J Epidemiol. 2026 Jun 1; Epub 2026 Jun 1
Authors: Grøtting N, Wolford BN, Kvaløy K, Omland T, Selbæk G, Ernstsen L
PubMed: 42223769
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Glial fibrillary acidic protein (GFAP) in biofluids: analytical considerations and clinical relevance in neurodegenerative diseases.

J Neurol. 2026 Jun 1;273(6)
Authors: Hanin A, Quadrio I, Beaudeux JL, Lamari F
PubMed: 42223663
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The complex of gut microbial metabolites and sex hormones in Alzheimer's disease.

Semin Immunopathol. 2026 Jun 1;48(1)
Authors: Bahar A, Khazaei M, Tahmasebi H
PubMed: 42223629
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Energy Stress-Induced Neuroprotection Against Ferroptosis in Dopaminergic Neurons.

J Neurochem. 2026 Jun;170(6):e70487.
Authors: Jonneaux A, Laine W, Maboudou P, Kluza J, Bonte MA, Gouel F, Devos D, Marchetti P, Devedjian JC
PubMed: 42223207
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Disrupting the Heart-Brain Axis: The Combined Impact of Parental Obesity and Alzheimer Disease.

Am J Physiol Heart Circ Physiol. 2026 Jun 1; Epub 2026 Jun 1
Authors: Speretta GF
PubMed: 42223193
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Psychometric Evidence for an Augmented PDAQ for Improved Measurement of Cognition-Related IADLs in Parkinson's Disease.

Mov Disord Clin Pract. 2026 Jun 1; Epub 2026 Jun 1
Authors: Regnault A, Delbecque L, M'Hari M, Mazerolle F, Biglan K, Chandler J, Schoen I, Mamikonyan E, Siderowf A, Weintraub D
PubMed: 42223169
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Coarse-Grained Simulations Reveal Salt- and Length-Dependent Condensation of G4C2 RNA Repeats.

J Phys Chem Lett. 2026 Jun 1; Epub 2026 Jun 1
Authors: Zhang Q, Valério M, Grünewald L, Borges-Araújo L, Grünewald F, Wang S, Marrink SJ, Gong Y, Souza PC
PubMed: 42223083
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Cognitive, Motor and Oculomotor Contributions to the Trail Making Test in Progressive Supranuclear Palsy.

Mov Disord Clin Pract. 2026 Jun 1; Epub 2026 Jun 1
Authors: Garcia-Cordero I, Hadian M, Vargas-Gonzalez JC, Monteiro M, Gold D, Khoja A, Morales-Rivero A, Couto B, Tang-Wai D, Fox S, Kovacs GG, Lang AE, Tartaglia MC
PubMed: 42223071
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Multisite study: Predicting Lewy body disease using skin biopsy α-synuclein seed amplification assays.

J Neuropathol Exp Neurol. 2026 Jun 1; Epub 2026 Jun 1
Authors: Janarthanam C, Orrú CD, Hughson AG, Holzinger D, Taylor K, Kanthasamy AG, Caughey B, Heym RG, Adler CH, Shill HA, Mehta S, Driver-Dunckley E, Ho AH, Choudhury P, Shprecher DR, Belden CM, Atri A, Zhang N, Chen K, Serrano GE, Beach TG
PubMed: 42223057
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Ex vivo comparison of ACU193 and lecanemab reveals binding differences in mouse brain.

Alzheimers Dement. 2026 Jun;22(6):e71509.
Authors: Grenon MB, Cline EN, Jerecic J, Johnson E, Siemers E, Lemere CA
PubMed: 42222928
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Influence of an AQP4 haplotype and sleep duration on early Alzheimer's disease.

Alzheimers Dement. 2026 Jun;22(6):e71540.
Authors: Palatsides EL, Yiallourou S, Himali D, Cavuoto MG, Baril AA, Yang Q, Peloso GM, Ryan J, El Fakhri G, Ghosh S, Thibault E, DeCarli CS, Johnson KA, Beiser AS, Seshadri S, Himali JJ, Pase MP
PubMed: 42222915
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Correction to "CRISPR/Cas9 screen in human iPSC-derived cortical neurons identifies NEK6 as a novel disease modifier of C9orf72 poly(PR) toxicity".

Alzheimers Dement. 2026 Jun;22(6):e71488.
Authors:
PubMed: 42222906
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Expanding roles of cGAS-STING signaling in neuroinflammation.

J Clin Invest. 2026 Jun 1;136(11) Epub 2026 Jun 1
Authors: Feng W, Aikedan A, Sinha SC, Gan L
PubMed: 42222892
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Multimodal analysis of cell-free DNA identifies epigenetic biomarkers for amyotrophic lateral sclerosis diagnosis and progression.

J Clin Invest. 2026 Jun 1;136(11) Epub 2026 Jun 1
Authors: Michels S, Chen C, Ruf WP, Garcia Garcia MM, Arnold FJ, Wu Z, Bennett CL, Shams D, Thompson LM, Walker AC, Dickson DW, Petrucelli L, Dorst J, Prudencio M, Li W, La Spada AR
PubMed: 42222887
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Do We Need to Monitor B-Vitamins and Homocysteine During Initiation of Foslevodopa/Foscarbidopa Therapy?

Mov Disord. 2026 Jun 1; Epub 2026 Jun 1
Authors: Shaghaghi-Zadeh A, Höllerhage M, Wegner F, Ye L, Schneidereit I, Hegelmaier T, Jacob R, Schrader C, Klietz M
PubMed: 42220319
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Disease-Specific Metabolic Patterns in Progressive Supranuclear Palsy with Richardson's Syndrome and Variants: A Longitudinal Study.

Mov Disord. 2026 Jun 1; Epub 2026 Jun 1
Authors: Jiao F, Lin H, Lu J, Liu F, Wang J, Wu J, Pang H, Wang J, Zuo C, Wu P, Progressive Supranuclear Palsy Neuroimage Initiative (PSPNI)
PubMed: 42220312
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EXPRESS: A perivascular perspective on the immune impacts in cerebral amyloid angiopathy.

J Cereb Blood Flow Metab. 2026 Jun 1;:271678X261454165. Epub 2026 Jun 1
Authors: Eyre B, Bonney SK
PubMed: 42220203
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Marine Algae and Neuroprotection: Unlocking the Therapeutic Potential Against Neurodegenerative Diseases.

Phytother Res. 2026 Jun 1; Epub 2026 Jun 1
Authors: Devi R, Temgire P, Kumar P
PubMed: 42220176
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EXPRESS: Quantification of 18F-SynVesT-1 binding in healthy aging and head-to-head comparison with 11C-UCB-J.

J Cereb Blood Flow Metab. 2026 Jun 1;:271678X261454164. Epub 2026 Jun 1
Authors: Vanderlinden G, Carron C, Van Opstal J, Cohilis M, Vandenberghe W, Koole M, Van Laere K
PubMed: 42219995
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Syndrome-specific vulnerability of neuronal and glial 4-repeat frontotemporal lobar degeneration-tau.

Brain. 2026 Jun 1; Epub 2026 Jun 1
Authors: Minogue G, Zouridakis A, Nelson C, Kawles A, Keszycki R, Macomber A, Weintraub S, Gill N, Mao Q, Jamshidi P, Castellani R, Mesulam MM, Geula C, Gefen T
PubMed: 42219867
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Neural Correlates of Anxiety in Alzheimer's Disease: An Analysis of the Amplitude of Low-Frequency Fluctuations in Resting-State fMRI.

J Coll Physicians Surg Pak. 2026 Jun;36(6):743-748.
Authors: Zhou B, He J, Wei F, Zhang Z, Chen B, Guo Z
PubMed: 42219832
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Reframing Alzheimer's Disease: An Energy Failure Rather Than a Memory Disorder.

J Coll Physicians Surg Pak. 2026 Jun;36(6):699-701.
Authors: Abdellah Ahmed MA, Shaikh AA
PubMed: 42219824
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Therapeutic Peptide SS-31 Modulates Membrane Binding and Aggregation of α-Synuclein and Restores Impaired Mitochondrial Function.

Chem Biol Drug Des. 2026 Jun;107(6):e70332.
Authors: Stefaniak E, Cui B, Yan X, Sun K, Teng X, Ying L
PubMed: 42219795
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Higher magnetic field NMR renders resolution enhancement on ganglioside GD3 catalyzed heterogeneous Aβ42 aggregates.

Solid State Nucl Magn Reson. 2026 Jun;143:102093. Epub 2026 Apr 25
Authors: Saha J, Ravula T, Ramamoorthy A
PubMed: 42061286
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Cell-specific energy crisis in the ageing brain: Mitochondrial dynamics drives neuron-glia metabolic uncoupling and neurodegeneration.

Mech Ageing Dev. 2026 Jun 1;232:112206. Epub 2026 Jun 1
Authors: Wang K, Liu Y, Zhang H, Li X, Zhou R, Shao W, Sun Z
PubMed: 42229862
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Engrailed, a target of the miR-92 family, attenuates Tau accumulation and associated memory deficits in Drosophila.

Biochim Biophys Acta Mol Cell Res. 2026 Jun 1;1873(6):120169. Epub 2026 Jun 1
Authors: Nguyen MN, Ryu TH, Lee JS, Hong SH, Yoon SE, Kim YJ, Yu K
PubMed: 42229860
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Engineered EV-mediated delivery of an anti-amyloid peptide provides neuroprotection in an in vitro Alzheimer's disease model.

Int J Pharm. 2026 Jun 1;700:127043. Epub 2026 Jun 1
Authors: Singh VB, Gupta S, Sella RN
PubMed: 42229832
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Exploratory multi‑omics analysis for candidate biomarker identification in Parkinson's disease.

Neuroscience. 2026 Jun 1; Epub 2026 Jun 1
Authors: Liu T, Cao S, Liang H, Wei J
PubMed: 42229831
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From capillaries to cognition: decoding neurovascular unit dysfunction and cerebrovascular contributions in Alzheimer's disease.

Biochem Pharmacol. 2026 Jun 1;251(Pt 1):118107. Epub 2026 Jun 1
Authors: Kumari N, Kumari S, Sharma P, Dhapola R, Paidlewar M, HariKrishnaReddy D
PubMed: 42229733
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Platelet-derived extracellular vesicles as neurodegenerative disease biomarkers.

Clin Chim Acta. 2026 Jun 1;:121130. Epub 2026 Jun 1
Authors: Alqahtani SM, Afzal M, Afzal O, Alabbas A, Phalak P, Goyal K
PubMed: 42229706
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Associations between posttraumatic stress and comorbidities of traumatic brain injury and substance use disorders with Alzheimer's disease in older veterans: A narrative review.

Ageing Res Rev. 2026 Jun 1;120:103188. Epub 2026 Jun 1
Authors: Reddy-Mazzitello RM, Alexander J, Skawratananond S, Sehar U, Mukherjee U, Brownell M, Ballada S, Reddy PH
PubMed: 42229590
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Mapping of motor and non-motor symptoms to 12-region dopamine transporter single-photon emission computed tomography in Parkinson's disease.

J Neurol. 2026 Jun 1;273(6)
Authors: Ozawa M, Ishii K, Yuzawa A, Yoshimaru D, Okano HJ
PubMed: 42228148
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Progress of Immunotherapies in Parkinson's Disease.

CNS Neurosci Ther. 2026 Jun;32(6):e70964.
Authors: Peng Y, Kang XH, Yao SY, Zhang X, Kazuo S, Liu J, Du MQ, Lin LX, Jiang DY, Chen Q, Jin H
PubMed: 42227981
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Planimetric and Linear MRI Markers for Progressive Supranuclear Palsy Classification: A Large Multicohort International Study.

Radiology. 2026 Jun;319(3):e251394.
Authors: Quattrone A, Bianco MG, Vescio B, Chimento I, Sacilotti A, Oliveti C, Arcuri PP, Stanà C, Tinelli E, Sabatini U, Kaasinen V, Franzmeier N, Stefanis L, Velonakis G, Boxer A, Constantinides VC, Höglinger GU, Quattrone A, PASSPORT Study Group, AL-108-231 Investigators, TAUROS MRI Investigators, DescribePSP group, AL-108-231 Study Group, Tau Restoration on PSP (TAUROS) MRI Investigators, DESCRIBE-PSP Study Group
PubMed: 42227858
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Improved Multiscale Structural Mapping with Supervertex Vision Transformer for the Detection of Alzheimer's Disease Neurodegeneration.

Hum Brain Mapp. 2026 Jun 1;47(8):e70548.
Authors: Baek G, Salat DH, Jang I, Alzheimer's Disease Neuroimaging Initiative
PubMed: 42227644
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Alcohol use and APOE ε4 interaction with cognitive domains among American adults from diverse racial/ethnic groups: A HABS-HD study.

Alzheimers Dement Behav Socioecon Aging. 2026 Jun;2(2) Epub 2026 Apr 14
Authors: Mendoza-Villena EP, Neelamegam M, Phillips N, Johnson L, Abdullah L, Hall J, O'Bryant S, Mun EY, Andrews SJ, Barber R, Pathak GA, Housini M, Zhang K, Zhou Z
PubMed: 42226812
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The CDK4/6 inhibitor abemaciclib attenuates cognitive impairment and neuroinflammation via DYRK1A in human tau transgenic mice.

Mol Brain. 2026 Jun 1; Epub 2026 Jun 1
Authors: Lee HJ, Hoe HS
PubMed: 42226198
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Distinct and combined interferon-ɑ/β-receptor-1 loss in neurons and astrocytes disrupt brain energy metabolism and drive Parkinsonian dementia.

J Biomed Sci. 2026 Jun 1;33(1)
Authors: Villanueva EB, Zebec Z, Cisquella-Serra M, Lundstrøm J, Andersen JV, Qvist FL, Westi EW, Marin A, Jimenez-Duran G, Riera-Ponsati L, Tresse E, Kretz O, Loreth D, Goldmann T, Blank T, Prinz M, Aldana BI, Mann M, Skotte NH, Issazadeh-Navikas S
PubMed: 42226039
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Emotion Perception in Behavioral Variant Frontotemporal Dementia and Alzheimer Disease: The Parahippocampal Conundrum.

Cogn Behav Neurol. 2026 Jun 1;39(2):43-52.
Authors: Morais RF, Duro D, Pires R, Lemos R, Lima M, Oliveira TG, Santana I
PubMed: 42235492
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LRRK2 G2019S as a shared mutation in two distinct double-mutant Parkinson's disease cases: First cases from Tunisia.

Parkinsonism Relat Disord. 2026 Jun 1;149:108375. Epub 2026 Jun 1
Authors: Mousli AA, Zouari R, Agrebaoui A, Zakaria S, Marzouki B, Nahdi H, Nabli F, Rachdi A, Ben Mohamed D, Ben Sassi S
PubMed: 42235482
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Reduction in hippocampal cholinergic neurostimulating peptide enhances memory impairment in AppNL-G-F KI mice.

Alzheimers Dement. 2026 Jun;22(6):e71531.
Authors: Tsuda Y, Madokoro Y, Suzuki K, Ooba T, Sato T, Uchida Y, Nagai-Arakawa I, Saito T, Hara H, Hida H, Matsukawa N
PubMed: 42233314
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Associations among sleep quality, cognitive decline, and Alzheimer's disease pathology in older adults: A longitudinal study.

Alzheimers Dement. 2026 Jun;22(6):e71470.
Authors: Shihadeh L, Rosselli M, Conniff J, Asken B, Goytizolo A, Barker W, Matusz EF, Collie A, Coombes SA, Armstrong M, Velez-Uribe I, Adjouadi M, Smith GE, Duara R, DeKosky SD, Loewenstein DA
PubMed: 42233291
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Stress, stress systems, and Alzheimer's disease.

Alzheimers Dement. 2026 Jun;22(6):e71542.
Authors: Eberly SG, Phumsatitpong C, Munro CE, Neylan TC, Kaufer D, Ehrenberg AJ
PubMed: 42233253
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Validity of the two different scoring methods of the Clinical Dementia Rating scale in staging and detection of cognitive impairment in the Peruvian population.

Alzheimers Dement. 2026 Jun;22(6):e71550.
Authors: Senador J, Montesinos R, Custodio B, Huilca J, Agüero K, Verastegui G, Bartolo P, Nuñez-Huanca M, Pereira MF, Custodio N
PubMed: 42233248
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Documented follow-up to memory concerns reported at the Medicare Annual Wellness Visit.

Alzheimers Dement. 2026 Jun;22(6):e71576.
Authors: Wec A, Wu M, Scerpella D, Zhang Z, Peereboom D, Colburn JL, Nothelle SK, Green AR, Wolff JL, Powell DS
PubMed: 42243620
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Aberrant tau accumulation caused by MAPT mutations induces early pathological changes in axonal transport that are rescued by p38α inhibition.

Nat Neurosci. 2026 Jun;29(6):1355-1368. Epub 2026 Jun 4
Authors: Moretto E, Masato A, Panzi C, Lopes AT, Stuart S, De La-Rocque S, Caso MG, White IJ, Harris SS, Busche MA, Schiavo G
PubMed: 42243402
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KGT: Knowledge-guided graph transformer for neurodegenerative disease diagnosis and brain age prediction with MRI.

Med Image Anal. 2026 Jun 1;113:104143. Epub 2026 Jun 1
Authors: Zhao J, Ding R, Liu M
PubMed: 42242081
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Deletion of Robo4 worsens neuroinflammation in a mouse model of Alzheimer's disease.

Physiol Rep. 2026 Jun;14(11):e70950.
Authors: Cullen AE, Winder NR, Lee B, Krishna Kumaran S, Arora N, Wolf JR, Henson GD, Woltjer RL, Walker AE
PubMed: 42237690
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Tramiprosate, the Active Agent of ALZ-801, Modulates Amyloidogenic APP Processing and Tau Phosphorylation in a Cellular Model of Alzheimer's Disease.

Drug Dev Res. 2026 Jun;87(4):e70330.
Authors: Biberoglu K, Tacal O
PubMed: 42237659
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AI-Driven discovery of brain-penetrant mTOR-independent autophagy enhancers for Alzheimer's disease.

Autophagy. 2026 May 31;:1-3. Epub 2026 May 31
Authors: Dong Y, Xiao X, Zhuang XX, Wu W, Fang EF, Yang G, Niu Z, Lu JH
PubMed: 42218670
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A Prodrug Approach for Activity-Based Chemical Modulation toward Multiple Pathological Targets in Alzheimer's Disease.

Small. 2026 May 31;:e74013. Epub 2026 May 31
Authors: Lee J, Hong E, Na C, Li Y, Go J, Kim JE, Seo HH, Suh JM, Kwak J, Lee YH, Kim KS, Lee CH, Kim M, Lim MH
PubMed: 42218630
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Stress Granules and Tau Pathology in Alzheimer's Disease: A Scoping Review of Bidirectional Interactions, Liquid-Liquid Phase Separation, and Proteostatic Consequences.

Brain Res Bull. 2026 May 31;:111974. Epub 2026 May 31
Authors: Kashtiban BA, Rezazadeh M, Gharesouran J, Jafari B, Ghafouri-Fard S
PubMed: 42225170
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Single-Nucleus Profiling Reveals a BBB Senescence Unit Driving AD Pathology in Human Brain.

Mol Neurobiol. 2026 May 31;63(1)
Authors: Zhang Y, Jin Z, Rao R, Si L, Zhang Z, Ma R, Min Y, Mei J, Yue Z, Fang X, Wei H
PubMed: 42223825
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LLPS Inflammasome Metabo-Proteostatic Failure Axis in AD: Mechanistic and Translational Insights.

Mol Neurobiol. 2026 May 31;63(1)
Authors: Bhatia V, Thakur T, Bisht G, Thakur H, Ashawat MS
PubMed: 42223531
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The skin as a sentinel organ for neurodegeneration: An underrecognized target for dementia prevention.

Intractable Rare Dis Res. 2026 May 31;15(2):156-165.
Authors: Han Y, Zhou C, Wang P, Karako K, Song P
PubMed: 42221048
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EXPRESS: Minute- and second-scale hippocampal network dysfunctions in the 3xTgAD mouse model of Alzheimer's disease are prevented by TSPO knockout.

J Cereb Blood Flow Metab. 2026 May 31;:271678X261454104. Epub 2026 May 31
Authors: Vidal B, Badina AM, Dorogan V, Schirmbeck G, Sanches E, Ceyzeriat K, Knoop M, Abjean L, Tsartsalis S, Sizonenko SV, Baud O, Millet P, Zerbi V, Tournier B
PubMed: 42219976
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[Progress in prognostic assessment methods for mild cognitive impairment].

Zhejiang Da Xue Xue Bao Yi Xue Ban. 2026 May 31;:1-16. Epub 2026 May 31
Authors: Lin J, Yu G
PubMed: 42226490
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AD-GPT: large language models in Alzheimer's disease.

BMC Med Inform Decis Mak. 2026 May 31; Epub 2026 May 31
Authors: Liu Z, Tang L, Sun Z, Liu Z, Lyu Y, Ruan W, Xu Y, Shan L, Shin J, Chen X, Zhu D, Liu T, Liu R, Huang C
PubMed: 42226232
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Mind-Body Interventions as Modulators of Neural Connectivity and Cognition in Individuals at Risk for Alzheimer's Disease: A Systematic Review.

Ann Neurosci. 2026 May 31;:09727531261441080. Epub 2026 May 31
Authors: Krishna D, Pandey AC, Nilesh S, Ananda S, Singh JA, Singh A
PubMed: 42238355
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Alzheimer's disease.

Lancet. 2026 May 30;407(10544):2241-2262.
Authors: Serrano-Pozo A, Escott-Price V, Grinberg LT, Pascoal T, Suárez-Calvet M, Dubois B, Sperling RA
PubMed: 42208565
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Efficacy and safety of intravenous prasinezumab in individuals with early-stage Parkinson's disease on stable symptomatic monotherapy (PADOVA): a phase 2b, multicentre, randomised, double-blind, placebo-controlled study.

Lancet. 2026 May 30;407(10544):2227-2240.
Authors: Nikolcheva T, Pagano G, Anzures-Cabrera J, Trundell D, Kustermann T, Simuni T, Marek K, Pavese N, Seppi K, Stocchi F, Postuma RB, Pross N, Monnet A, Respondek G, Schlegel V, Boak L, Rutten-Jacobs L, Kerchner GA, Brundin P, Svoboda H, Bonni A, PADOVA Investigators, Prasinezumab Study Group
PubMed: 42208564
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Comparison of [18F]flortaucipir and [18F]MK6240 for the detection of tau pathology in Alzheimer's disease (HEAD): a multicentre, prospective, cross-sectional, within-participant study.

Lancet. 2026 May 30;407(10544):2217-2226.
Authors: Povala G, Bellaver B, Lussier FZ, Amaral L, Bauer-Negrini G, Ferreira PC, Rocha A, Ruppert E, Medeiros MS, Tissot C, Jagust WJ, Masdeu JC, Fortea J, Tudorascu DL, Soleimani-Meigooni DN, Lowe V, Oh H, Pascual B, Gordon BA, Rosa-Neto P, Baker S, Pascoal TA, HEAD Study
PubMed: 42208563
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Alzheimer's disease neuropathology plasma biomarkers and cognition in midlife: a community-based cohort study.

Lancet. 2026 May 30;407(10544):2208-2216.
Authors: Jiang X, Hoang TD, Shaw LM, Jacobs DR Jr, Nasrallah IM, Bryan RN, Yaffe K
PubMed: 42208562
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Reisa Sperling: getting ahead of Alzheimer's disease.

Lancet. 2026 May 30;407(10544):2164.
Authors: McLellan F
PubMed: 42208558
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Multi-arm multi-stage platform trials for neurological disease: accelerating progress.

Lancet. 2026 May 30;407(10544):2154-2156.
Authors: Malhotra P, Pal S, Tallantyre E, Foltynie T, Carroll C, Chandran S, Carpenter J, Parmar M, Scott S, Chataway J
PubMed: 42208555
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Blood biomarkers for Alzheimer's disease: from detection to decisions.

Lancet. 2026 May 30;407(10544):2151-2154.
Authors: Suárez-Calvet M, Salvadó G, de Fortuny BB, Del Campo M
PubMed: 42208554
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Prasinezumab: what have we learned from PASADENA and PADOVA?

Lancet. 2026 May 30;407(10544):2150-2151.
Authors: Foltynie T
PubMed: 42208553
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Advancing tau-PET imaging in Alzheimer's disease.

Lancet. 2026 May 30;407(10544):2148-2149.
Authors: Therriault J
PubMed: 42208552
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Plasma biomarkers for Alzheimer's disease among middle-aged individuals.

Lancet. 2026 May 30;407(10544):2146-2147.
Authors: Rosenberg A, Ngandu T
PubMed: 42208551
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Longitudinal amyloid PET changes by cerebrospinal fluid amyloid and tau profiles in individuals with normal cognition: Role of APOE ε4.

J Alzheimers Dis. 2026 May 30;:13872877261453099. Epub 2026 May 30
Authors: Rizzo M, Oomens JE, Jansen WJ, Visser PJ, Vos SJ, AMYPAD consortium
PubMed: 42216672
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Cannabinoids for Alzheimer's disease: A promising trial, although not yet ready for the prescription pad.

J Alzheimers Dis. 2026 May 30;:13872877261452183. Epub 2026 May 30
Authors: Dos Santos Silva J
PubMed: 42216668
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Bibliometric analysis of natural medicine in the treatment of Alzheimer's disease: Trends, hotspots, and emerging research fields.

J Alzheimers Dis. 2026 May 30;:13872877261451887. Epub 2026 May 30
Authors: Wen T, Zhu T, Zhou LY, Ran Z, Chen L, Wang WJ
PubMed: 42216664
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A century of coffee and tea research in cognitive health and Alzheimer's disease: Structural, thematic, and translational insights (1911-2025).

J Alzheimers Dis. 2026 May 30;:13872877261450996. Epub 2026 May 30
Authors: Taha MM, Abdelwahab SI, Sahli KA, Jeraiby M, Qadri M, Alarifi A, Farasani A, Moshi JM
PubMed: 42216624
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Blood-based biomarkers and the current landscape of Alzheimer's disease diagnosis: ethical considerations and practical guidance.

J Clin Exp Neuropsychol. 2026 May 30;:1-13. Epub 2026 May 30
Authors: Naini SM, Mantyh WG, Waldron EJ, Satin DJ, Basso MR, Garland M, McManimen S, Whiteside DM
PubMed: 42218590
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White matter 18F-florbetapir retention predicts cognitive decline and treatment response in Alzheimer's disease.

Alzheimers Res Ther. 2026 May 30; Epub 2026 May 30
Authors: Lin H, Zhang Y, Ni R, Wang M, Men J, Ge J, Lu J, Wang J, Zhang H, Yang Y, Zhang Z, Zhu Y, Zhao H, Yen TC, Wang J, Shi K, Rominger A, Guan Y, Fang M, Yu J, Jiang J, Zuo C
PubMed: 42218511
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Partnering with Latino communities for dementia research: a mixed-methods study of engagement.

Res Involv Engagem. 2026 May 30;12(1)
Authors: Masoud SS, Choi BY, Escareño J, Flores B, Lorenzo KD, White CL
PubMed: 42218508
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The vicious cycle: unraveling the interplay between α-synuclein, mitochondrial dysfunction, and neuroinflammation in Parkinson's disease.

J Neurol. 2026 May 30;273(6)
Authors: Liang YL, Yang FG, Tang Q
PubMed: 42218352
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Corrigendum to "Toll-like receptor-4 mediates neuronal apoptosis induced by amyloid β-peptide and the membrane lipid peroxidation product 4-hydroxynonenal" [Experimental Neurology, vol. 213,1 (2008): 114-21].

Exp Neurol. 2026 May 30;:115833. Epub 2026 May 30
Authors: Tang SC, Lathia JD, Selvaraj PK, Jo DG, Mughal MR, Cheng A, Siler DA, Markesbery WR, Arumugam TV, Mattson MP
PubMed: 42218080
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A combined neuronal extracellular vesicle-haematology panel for clinical stratification of Alzheimer's disease and dementia.

Metab Brain Dis. 2026 May 30;41(1)
Authors: Ganji P, G PR, N BK, Bendre RV, Ghosh A, Prabhakar S, K RM, Manda SV
PubMed: 42217083
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GRP78 associates with alpha-synuclein in vulnerable neurons of the Parkinson's disease brain.

Acta Neuropathol. 2026 May 30;151(1)
Authors: Hrabos D, Mrowiecova A, Cicmancova J, Ehrmann J
PubMed: 42217054
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Head-to-head comparison of [18F]CHL2205 versus [18F]T008 as PET radioligands to study brain cholesterol homeostasis in rodent models and nonhuman primates.

Eur J Nucl Med Mol Imaging. 2026 May 30; Epub 2026 May 30
Authors: Goutal S, Caille F, Piguet F, Goislard M, Amargier-Barrial S, Leterrier S, Marie S, Bottlaender M, Tournier N
PubMed: 42216974
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Cu(ATSM) Restores Blood-Brain Barrier Abundance of P-Glycoprotein and Improves Cognitive Function in the APP/PS1 Mouse Model of Alzheimer's Disease.

ACS Chem Neurosci. 2026 May 30; Epub 2026 May 30
Authors: Pyun J, Noor A, Runwal P, Mawal C, Fuller OK, Egan CL, Febbraio MA, Donnelly PS, Short JL, Bush AI, Nicolazzo JA
PubMed: 42216879
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Association of probiotic medication use with incident Parkinson disease and alzheimer disease: a nationwide nested case-control study.

J Neurol. 2026 May 30;273(6)
Authors: Ihara Y, Miyaue N, Ihara M, Kurata T, Nagai M
PubMed: 42223673
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Lysosome-targeted near-infrared fluorescent probes for monitoring aβ plaques in vivo and aβ monomers dynamic degradation in vitro.

Spectrochim Acta A Mol Biomol Spectrosc. 2026 May 30;362:128160. Epub 2026 May 30
Authors: Gong H, Li Z, Zhao Y, Wang Z, Luo W
PubMed: 42242142
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Multidimensional cognitive deficit in logopenic variant primary progressive aphasia: a case report.

J Med Case Rep. 2026 May 29;20(1)
Authors: Puspitasari V, Ramli Y, Lastri DN, Prawiroharjo P, Wijaya JH
PubMed: 42216192
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EEG biomarkers can predict early-stage Alzheimer's disease and correlate with intracerebral pathology: a multimodal machine learning study.

Alzheimers Res Ther. 2026 May 29; Epub 2026 May 29
Authors: Geng Z, Song W, Gao C, Zhu Y, Wu Y, Song B, Guo H, Wu J, Fang M, Yan Y, Zhou S, Hu P, Tian Y, Wu X, Wang K, Wei L
PubMed: 42216097
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Blocking estrogen receptors restores surface mGluR5 but not downstream signaling in female APP/PS1 Mice.

Mol Brain. 2026 May 29; Epub 2026 May 29
Authors: Ibrahim KS, Albaker A, Abd-Elrahman KS, Ferguson SS
PubMed: 42216035
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Physical exercise in combination with audiovisual stimulation alleviates cognitive and affective impairments in Alzheimer's disease model mice via restoring lysosomal membrane integrity.

Alzheimers Res Ther. 2026 May 29; Epub 2026 May 29
Authors: Jia J, Xie G, Zheng W, Xu C, Xia Y, Hu Q, Xiang B, Zhou X, Chen A, Chen X, Wang Q, Zhou Y, Xu S
PubMed: 42216028
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Convergence of neuroinflammation across major neurotropic viral exposomes in AD and ADRD.

J Neuroinflammation. 2026 May 29; Epub 2026 May 29
Authors: Harmouch J, Green R, Mayilsamy K, Tosi K, Mohapatra S, Mohapatra SS
PubMed: 42215997
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Explainable machine learning for the prediction of Alzheimer's disease-related cognitive impairment: a consensus feature selection approach.

BMC Med Inform Decis Mak. 2026 May 29; Epub 2026 May 29
Authors: Cantaş Türkiş F
PubMed: 42215935
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Correlation analysis of positive Alzheimer's disease plasma biological markers with plasma immune cell and clinical characteristics in mild cognitive impairment patients in China.

BMC Immunol. 2026 May 29; Epub 2026 May 29
Authors: Wang L, Zhang P, Gao S, Liu H, Qiu X, Yang S, Wei L, Li Y, Cai Y, Yang J
PubMed: 42215876
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The C9orf72/SMCR8 complex maintains microglial homeostasis via RAB8A-ESCRT-mediated lysosomal repair.

EMBO J. 2026 May 29; Epub 2026 May 29
Authors: Li S, Xu S, Li F, Zhao Q, Zhang P, Guan Q, Sun X, Bi J, Xiao H, Tang Y, Peng C, Chen Q, Wang Y, Yang M
PubMed: 42215790
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An unexpected molecular explanation for how tau aggregation begins in Alzheimer's disease.

Nat Neurosci. 2026 May 29; Epub 2026 May 29
Authors:
PubMed: 42215644
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Assessing the de novo paradigm in sporadic early-onset Alzheimer disease trios.

Mol Psychiatry. 2026 May 29; Epub 2026 May 29
Authors: Zarea A, Cassinari K, Lecoquierre F, Quenez O, Charbonnier C, Schramm C, Lacour M, Rousseau S, Richard AC, Rovelet-Lecrux A, Lecourtois M, Olaso R, Boland A, Deleuze JF, Gilissen C, Veltman JA, Vissers LE, Bellenguez C, Dols-Icardo O, Hardy J, Holstege H, Hulsman M, Lambert JC, Mead S, Ramirez A, Sims R, van Swieten J, Wagner M, Williams J, Bombois S, Boutoleau-Bretonniere C, Charmard-Witkowski L, de la Sayette V, Deramecourt V, Etcharry-Bouyx F, Gabelle A, Gueriot C, Le Guyader G, Le Ber I, Lebouvier T, Martinaud O, Michon A, Quelin C, Sarazin M, Sévin M, Thauvin-Robinet C, Wallon D, Nicolas G
PubMed: 42215639
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Association between microRNA 155 gene polymorphism and sporadic Parkinson's disease.

Per Med. 2026 May 29;:1-8. Epub 2026 May 29
Authors: Luo S, Li J, Zhang Y, Zou Y
PubMed: 42215422
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Comorbid neuropathologies but not Braak stage influence cognitive impairment in primary age-related tauopathy.

J Neuropathol Exp Neurol. 2026 May 29; Epub 2026 May 29
Authors: Kandoi S, Hiya S, Maldonado-Díaz C, Rohde SK, Bernardes C, Almeida FC, Samanamud J, Clare K, Virata MC, Slocum CC, Mir E, White CL 3rd, Daoud EV, Farrell K, Crary JF, Oliveira TG, Gonzales MM, Walker JM, Richardson TE
PubMed: 42215016
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Subjective cognition trajectories, Alzheimer biomarkers, and incident mild cognitive impairment.

J Prev Alzheimers Dis. 2026 May 29;13(8):100609. Epub 2026 May 29
Authors: Kuhn E, Kleineidam L, Stark M, Peters O, Hellmann-Regen J, Preis L, Gref D, Priller J, Spruth EJ, Gemenetzi M, Schneider A, Fliessbach K, Wiltfang J, Bartels C, Hansen N, Rostamzadeh A, Düzel E, Glanz W, Incesoy E, Buerger K, Janowitz D, Stöcklein S, Perneczky R, Rauchmann BS, Teipel SJ, Kilimann I, Laske C, Sodenkamp S, Spottke A, Kronmüller M, Roeske S, Brosseron F, Ramirez A, Synofzik M, Schmid MC, Jessen F, Wagner M, Alzheimer’s Disease Neuroimaging Initiative, DELCODE study group
PubMed: 42214902
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Physiological brain clearance architecture revealed by neuronal protein tracing.

Cell. 2026 May 29; Epub 2026 May 29
Authors: Chayama Y, Rao NR, Perla D, Zhang Z, Reid M, Nelson S, Wen X, Ding B, Blumenfeld J, Apolonio A, Doddipalli S, Zhou H, Turhan SG, Shih PY, Brendel M, Fu YH, Ertürk A, Kolabas ZI, Huang Y, Yang AC
PubMed: 42214342
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Can table tennis protect the aging brain? A systematic review and meta-analysis in neurodegenerative diseases.

Acta Psychol (Amst). 2026 May 29;267:107135. Epub 2026 May 29
Authors: Łosińska K, Maszczyk A
PubMed: 42214165
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Acceptability of Technologies to Support Early Dementia Detection: Qualitative Study With the Boston University Alzheimer's Disease Center Cohort.

J Med Internet Res. 2026 May 29;28:e84004.
Authors: Wilson S, Beswick E, Popp Z, Rahman S, Bhogal S, Whitfield T, Low S, Khan R, Tolley C, Walker Z, Au R, Slight SP
PubMed: 42213912
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Clinical markers of disease progression in the prodromal to overt alpha-synucleinopathy continuum.

Brain. 2026 May 29; Epub 2026 May 29
Authors: Roascio M, Antelmi E, Baldelli L, Biscarini F, Bonanni E, Brunetti V, Capriglia E, Geromino C, Casoni F, Cirillo F, Della Marca G, Di Laudo F, Ferini-Strambi L, Fernandes M, Figorilli M, Galbiati A, Gigli GL, Guarnieri B, Hoxhaj D, Lanza G, Liguori C, Tassoni MM, Maio S, Malomo G, Marelli S, Mattioli P, Mulas M, Orso B, Pardini M, Plazzi G, Provini F, Pellitteri G, Puligheddu M, Terzaghi M, Pelletier A, Postuma RB, Arnulfo G, Arnaldi D
PubMed: 42213896
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Reevaluating the role of beta2-microglobulin: new insights on selective vulnerability in ALS pathology.

Acta Neuropathol. 2026 May 29;151(1)
Authors: Leboeuf M, Nijssen J, Comley LH, Aguila Benitez JC, Mei I, Gómez Alcalde S, Muñoz de Bustillo-Alfaro RA, Radoi V, Nichterwitz S, Schweingruber C, Acevedo Arozena A, Hedlund E, Cullheim S
PubMed: 42213237
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Differential expression of PPAR isoforms in streptozotocin induced model of sporadic alzheimer's disease in zebrafish.

Mol Biol Rep. 2026 May 29;53(1)
Authors: Dhiman N, Patial K, Sandhir R
PubMed: 42213199
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Iatrogenic cerebral amyloid angiopathy: neuroinflammation and implications for future therapies.

Neurol Sci. 2026 May 29;47(6)
Authors: Frol S, Zupan M
PubMed: 42213169
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Beyond motor: a systematic review of multisensory integration deficits in Parkinson's disease.

J Neural Transm (Vienna). 2026 May 29; Epub 2026 May 29
Authors: Azizi Z, Setti A, Bruno V, Prehn JH, Idri A, Ward T
PubMed: 42213165
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Parkinson's disease-subjective cognitive decline and health-related quality of life.

J Neural Transm (Vienna). 2026 May 29; Epub 2026 May 29
Authors: Rodriguez-Antiguedad J, Puig-Davi A, Franch-Marti C, Bojtos L, Martínez-Horta S, Pagonabarraga J, Alonso Losada MG, Alonso Redondo R, Álvarez Sauco M, Ávila-Rivera MA, Borrué C, Cabo I, Caballol N, Cubo E, Dotor García-Soto J, Escalante S, García Caldentey J, García-Ramos R, Gastón I, González-Ortega G, Hernández-Vara J, Infante J, Kurtis M, Vives B, López Ariztegui N, López Manzanares L, Martínez Castrillo JC, Menéndez-González M, Ordás C, Pons Pons G, Puy Núñez A, Ruíz Martínez J, Sánchez-Alonso P, Seijo M, Solano Vila B, Valero Merino C, Vela L, Mir P, Santos-García D, COPPADIS Study Group, Kulisevsky J
PubMed: 42213164
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DNA nanocage-assisted multiplex fluorescence quantification of size-fractionated low-mass soluble amyloid-β oligomers.

Anal Bioanal Chem. 2026 May 29; Epub 2026 May 29
Authors: Chen J, Yu C, Xiang J
PubMed: 42213122
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Amyloid precursor protein ortholog Appl acts with Vnd during mushroom body axon growth in Drosophila.

Genetics. 2026 May 29; Epub 2026 May 29
Authors: Marquilly C, Busto GU, Pasquer L, Zinzen RP, Hassan BA, Fradkin LG, Preat T, Boulanger A, Dura JM
PubMed: 42213044
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Synaptic Vesicle Architecture Modulates α-Synuclein Conformation and Pathogenic Transitions in Parkinson's Disease.

Biosci Rep. 2026 May 29; Epub 2026 May 29
Authors: Ranjan P
PubMed: 42212534
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Associations between Alzheimer's disease blood biomarkers and neighborhood disadvantage: A HABS-HD community cohort study.

J Alzheimers Dis. 2026 May 29;:13872877261452660. Epub 2026 May 29
Authors: Miller JB, Rhoads T, Vintimilla R, Petersen M, Wong CG, Zhang F, Kind AJ, O'Bryant SE, HABS-HD Study Team
PubMed: 42212447
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Adolescent intermittent ethanol exacerbates amyloid-β with age in the dorsal hippocampus of female TgF344-AD rats.

J Alzheimers Dis. 2026 May 29;:13872877261453081. Epub 2026 May 29
Authors: Day SM, Reitz NL, Savage LM
PubMed: 42212444
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Exploratory study on the synergistic use of plasma neurofilament light chain, phosphorylated Tau181, and retinal examination for assessing the risk of Alzheimer's disease and mild cognitive impairment.

J Alzheimers Dis. 2026 May 29;:13872877261453611. Epub 2026 May 29
Authors: He X, Liu W, Liu R, Li B, Xu X, Cheng Y, Li Y, Jiang H
PubMed: 42212442
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Biomarkers of angiogenesis in Alzheimer's disease: Systematic review and meta-analysis.

J Alzheimers Dis. 2026 May 29;:13872877261453391. Epub 2026 May 29
Authors: Kapoor A, Nguyen AD, Joyce JL, Gaubert A, Duke Han S, Hughes CC, Nation DA
PubMed: 42212439
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Genetically prioritized druggable targets for amyloid-β pathology highlight ACE as a therapeutic candidate in Alzheimer's disease.

J Alzheimers Dis. 2026 May 29;:13872877261454540. Epub 2026 May 29
Authors: Kim JP, Lee H, Kim BH, Kang H, Shin D, Yim S, Kim S, Seo SW, Kim HN
PubMed: 42212431
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Xerogel-Engineered Graphitic Carbon Nitride Interfaces Enable Aptamer-Based Detection of Salivary Lactoferrin for Noninvasive Diagnosis of Alzheimer's Disease.

ACS Chem Neurosci. 2026 May 29; Epub 2026 May 29
Authors: Talukdar B, Verma D, Packirisamy G
PubMed: 42210866
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VAPB confers selective neuroprotection by driving autophagic degradation of pathogenic aggregates in ALS.

Acta Neuropathol Commun. 2026 May 29; Epub 2026 May 29
Authors: Tripathi P, Guo H, Yamoah A, Mathur R, Doukas P, Dreser A, Jesse CM, Aronica E, Hermann A, Steinbusch H, Brook GA, Weis J, Goswami A
PubMed: 42210413
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Early, sex-dependent and progressive proteomic imbalance in the amygdala during Alzheimer´s disease continuum.

Biol Sex Differ. 2026 May 29; Epub 2026 May 29
Authors: Romero-Murillo S, Lachén-Montes M, Cartas-Cejudo P, Anaya-Cubero E, de Miguel M, Extramiana L, Ferrer I, Fernández-Irigoyen J, Santamaría E
PubMed: 42210396
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Stage-specific regional distribution of amyloid and tau deposition across the Alzheimer's disease continuum revealed by tau-to-amyloid ratio imaging.

Eur J Nucl Med Mol Imaging. 2026 May 29; Epub 2026 May 29
Authors: Ishii K, Yamada T, Hanaoka K, Kojita Y, Kono A, Kaida H, Nihashi T, Sakurai K, Kato T, Nakamura A
PubMed: 42209819
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The physiological effects of APOE genotype in healthy young/middle-aged individuals.

Biol Rev Camb Philos Soc. 2026 May 29; Epub 2026 May 29
Authors: de Leeuw SM, Emrani S, Putter J, Nuriel T
PubMed: 42216420
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Common biomarkers of Alzheimer disease and postoperative delirium.

Medicine (Baltimore). 2026 May 29;105(22):e48921.
Authors: Fang Y, Zhang X, Zhan G
PubMed: 42216384
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Fluid-based biomarkers of amyotrophic lateral sclerosis: recent advances and future prospects.

Brain Res. 2026 May 29;1888:150395. Epub 2026 May 29
Authors: Jiang Y, Hu S, Yang B, Zhang L, Wang Y, Yang G, Zhang H
PubMed: 42217760
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Multi-functionalized chitosan-Extracellular vesicles nanohybrid system for intranasal delivery of pApoE2 to attenuate age-related inflammation.

Int J Biol Macromol. 2026 May 29;369:152803. Epub 2026 May 29
Authors: Gothwal A, Muolokwu CE, Belin MA, Tagoe BN, Frey WH 2nd, Zhao J, Parsons TM, Kanekiyo T, Singh J
PubMed: 42217698
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Enhancing the specificity of microglia genetic targeting using a CSF1R inhibitor.

Cell Rep. 2026 May 29;45(6):117411. Epub 2026 May 29
Authors: Babcock IW, Labuzan SA, Kelly AG, Schuster AE, Alemu S, Sibley LA, Marchildon AE, Harris TH
PubMed: 42217186
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Lecanemab promotes Fc receptor-dependent cell-mediated internalization and degradation of aggregated amyloid-beta in vitro and ex vivo.

Neurosci Lett. 2026 May 28;882:138645. Epub 2026 May 28
Authors: Fritz N, Johannesson M, Eriksson F, Osswald G, Lannfelt L, Möller C, Söderberg L
PubMed: 42214748
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Isoquercetin-ligustrazine co-polymorph attenuates hypoxia-accelerated Alzheimer's disease by suppressing PERK-CHOP-mediated ER stress.

Exp Neurol. 2026 May 28;404:115856. Epub 2026 May 28
Authors: Long X, Shen R, Yang Y, Xu Y, Wang Y, He Y, Xie Y, Xie X, Gao D, Pang X, Du L
PubMed: 42214747
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Yeast-derived vacuoles as potential therapeutic agents for modulating neuroinflammation in Alzheimer's disease.

Nanomedicine. 2026 May 28;75:102963. Epub 2026 May 28
Authors: Nguyen HT, Hwang YY, Park RM, Kim YH, Min J, Choi DW
PubMed: 42214647
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TGM2 drives microglial senescence by inhibiting autophagy via the PI3K/AKT/mTORC1 pathway.

Free Radic Biol Med. 2026 May 28; Epub 2026 May 28
Authors: Li Z, Tang Y, Zhang D, Li J, Wang T, Pan Q, Meng X, Tian X, Deng H
PubMed: 42214642
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Ext1-targeted gene therapy ameliorates tauopathy by inhibiting heparan sulfate-dependent tau propagation.

Pharmacol Res. 2026 May 28;230:108265. Epub 2026 May 28
Authors: Huang R, Ye X, Liu J, Yang C, Meng X, Dou T, Zhuang X, Yang J, Zheng N, Zhao Y, Wang Z, Wang Q, Hu J
PubMed: 42214573
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Neuroprotective effects of Uncaria rhynchophylla alkaloid extracts against amyloid-β toxicity via regulation of oxidative stress pathways.

J Ethnopharmacol. 2026 May 28;369:121918. Epub 2026 May 28
Authors: Zhong RF, Chen ZQ, Li SF, Jiang JG
PubMed: 42214568
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CD5L promotes phagocytic removal of amyloid β oligomers and improves cognitive function in a mouse model of Alzheimer's disease.

Cell Rep. 2026 May 28;45(6):117468. Epub 2026 May 28
Authors: Maehara N, Hattori S, Nakamura A, Nagatoishi S, Hirota A, Kudo K, Yoshikawa Y, Matsunaga R, Tsumoto K, Miyakawa T, Arai S, Miyazaki T
PubMed: 42213773
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Corrigendum to "Mini-Mental State Examination in Elderly Chinese: A Population-Based Normative Study.".

J Alzheimers Dis. 2026 May 28;:13872877261453263. Epub 2026 May 28
Authors:
PubMed: 42210671
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From phenotype to biology: a multi-modal roadmap of biofluid, tissue, imaging, and digital biomarkers in Parkinson's disease.

Transl Neurodegener. 2026 May 28;15(1)
Authors: Yu Z, Su D, Li S, Lin S, Ren K, Feng T
PubMed: 42210437
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Meprin-β levels are increased in the brain and the cerebrospinal fluid of Alzheimer's disease patients.

Alzheimers Res Ther. 2026 May 28; Epub 2026 May 28
Authors: Escamilla S, Avilés-Granados C, Márquez-Marco C, Keller M, Sánchez-Domínguez I, Cuchillo-Ibáñez I, Aguado F, Zetterberg H, Pietrzik CU, Sáez-Valero J
PubMed: 42210401
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Epigenetic brain reprogramming rejuvenates neuro-immune circuits to reverse Alzheimer's disease pathology and systemic bone loss.

J Neuroinflammation. 2026 May 28; Epub 2026 May 28
Authors: Wan MD, Liu XX, Wan TF, Liu YW, Jiang YL, Zou JT, Jiao B, Liu QQ, Jin L, Duan R, Wang Z, Hong CG, Wang X, Hu XY, Liao XX, Cao J, Shen L, Xie H, Wang ZX
PubMed: 42210397
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Examining the additive risk of TBI and comorbid conditions on dementia in military veterans: a retrospective cohort study.

Alzheimers Res Ther. 2026 May 28; Epub 2026 May 28
Authors: Clark AL, Valocchi E, McGill MB, Lopez FV, Chanfreau-Coffinier C, Thomas KR, Jester DJ, Logue MW, Merritt VC
PubMed: 42210358
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Plant-mediated green nanoparticles: combining nanometal and biometabolite potential for Alzheimer's treatment.

Biomed Eng Online. 2026 May 28; Epub 2026 May 28
Authors: Behzad F, Leili FR, Ebrahimi MJ, Moafi M, Kenari PB, Alizadeh A, Adeli S, Khosravani M, Jadidi Kouhbanani MA, Fahanik-Babaei J
PubMed: 42210357
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Integrated imaging and molecular profiling reveals APOE4-associated neurovascular and glial disruptions in young adult mice.

J Neuroinflammation. 2026 May 28; Epub 2026 May 28
Authors: Guan Y, Cheng CH, Khanna SD, Fader C, Ohene Y, Wells JA, Koo BB
PubMed: 42210271
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Molecular Imaging of Butyrylcholinesterase Associated with Amyloid-β Plaques Distinguishes 5XFAD from Wild-Type Mice: A Proof-of-Concept.

Mol Imaging Biol. 2026 May 28; Epub 2026 May 28
Authors: Reid GA, DeBay DR, Macdonald IR, Laouz AB, Pottie IR, Darvesh S
PubMed: 42209955
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Gut microbiome screens could identify risk of Parkinson's disease years before symptoms appear.

Nat Med. 2026 May 28; Epub 2026 May 28
Authors:
PubMed: 42209780
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Genetic-exposome interactions and aging clocks in dementia: the ReDLat2 initiative.

Nat Med. 2026 May 28; Epub 2026 May 28
Authors: Ibáñez A, Yokoyama JS, Duran-Aniotz C, Miller BL, Multi-Partner Consortium to Expand Dementia Research in Latin America (ReDLat)
PubMed: 42209779
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Convergent mitochondrial impairment and apoptosis driven by simultaneous down-regulation of multiple genes at 11p11.2 in Alzheimer's disease.

Mol Psychiatry. 2026 May 28; Epub 2026 May 28
Authors: Yu J, Xu M, Wu XR, Kang WB, Zou WY, Liu Q, Zhang DF, Yao YG
PubMed: 42209703
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Quantitative LC-MS/MS profiling reveals aberrant chondroitin sulfate in Alzheimer's disease.

Commun Biol. 2026 May 28; Epub 2026 May 28
Authors: Xu Y, Wang H, Wang Z, Zhang J, Stancanelli E, Xu Q, Hou Y, Wang C, Zhang P, Gearing M, Liu J
PubMed: 42209655
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Genetic variation in antidiabetic drug targets: associations with Parkinson's disease risk and age at onset.

NPJ Parkinsons Dis. 2026 May 28;12(1)
Authors: Vincze K, Szwajda A, Ploner A, Karlsson R, Kang X, Tang B, Qin C, Domenighetti C, Sugier PE, Ashok Kumar Sreelatha A, Schulte C, Portugal B, May P, Bobbili DR, Radivojkov-Blagojevic M, Lichtner P, Singleton AB, Hernandez DG, Edsall C, Mellick GD, Zimprich A, Pirker W, Rogaeva E, Lang AE, Koks S, Taba P, Lesage S, Brice A, Corvol JC, Chartier-Harlin MC, Mutez E, Brockmann K, Deutschlander AB, Burbulla LF, Hadjigeorgiou GM, Dardiotis E, Stefanis L, Simitsi AM, Valente EM, Petrucci S, Straniero L, Zecchinelli A, Pezzoli G, Brighina L, Ferrarese C, Annesi G, Quattrone A, Gagliardi M, Matsuo H, Nakayama A, Hattori N, Nishioka K, Chung SJ, Kim YJ, Kolber P, Van de Warrenburg BP, Bloem BR, Toft M, Pihlstrøm L, Correia Guedes L, Ferreira JJ, Bardien S, Carr J, Tolosa E, Ezquerra M, Pastor P, Ran C, Belin AC, Puschmann A, Clarke CE, Morrison KE, Tan M, Krainc D, Farrer MJ, Landoulsi Z, Kruger R, Gasser T, Elbaz A, Sharma M, Pedersen NL, Carlsson S, Hägg S, Wirdefeldt K, Comprehensive Unbiased Risk Factor Assessment for Genetics and Environment in Parkinson’s Disease (COURAGE-PD) Consortium, Domenighetti C, Sugier PE, Ashok Kumar Sreelatha A, Schulte C, Portugal B, May P, Bobbili DR, Radivojkov-Blagojevic M, Lichtner P, Singleton AB, Hernandez DG, Edsall C, Mellick GD, Zimprich A, Pirker W, Rogaeva E, Lang AE, Koks S, Taba P, Lesage S, Brice A, Corvol JC, Chartier-Harlin MC, Mutez E, Brockmann K, Deutschlander AB, Burbulla LF, Hadjigeorgiou GM, Dardiotis E, Stefanis L, Simitsi AM, Valente EM, Petrucci S, Straniero L, Zecchinelli A, Pezzoli G, Brighina L, Ferrarese C, Annesi G, Quattrone A, Gagliardi M, Matsuo H, Nakayama A, Hattori N, Nishioka K, Chung SJ, Kim YJ, Kolber P, Van de Warrenburg BP, Bloem BR, Toft M, Pihlstrøm L, Correia Guedes L, Ferreira JJ, Bardien S, Carr J, Tolosa E, Ezquerra M, Pastor P, Ran C, Belin AC, Puschmann A, Clarke CE, Morrison KE, Tan M, Krainc D, Farrer MJ, Landoulsi Z, Kruger R, Gasser T, Elbaz A, Sharma M, Wirdefeldt K
PubMed: 42209523
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Superior dorsal nigral hyperintensity depiction at 7 T MRI using CLEAR-DESS improves diagnosis performance of Parkinson's disease.

NPJ Parkinsons Dis. 2026 May 28; Epub 2026 May 28
Authors: Li S, Chen R, Li Q, Hsu Y, He J, Su Y, Wang D, Zhou H, Zhang W, Meng L, Liu S, Tang J, Li C, Lei P, Qian L, Qu J, Xing W, Bai HX, Liao W
PubMed: 42209516
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Distinctive characteristics of dopamine neuron release mechanisms: Insights into Parkinson's Disease.

Biomed Pharmacother. 2026 May 28;200:119534. Epub 2026 May 28
Authors: Martino ED, Maduro S, Luchicchi A, Wilhelmus MM, Orefice NS
PubMed: 42208351
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Advancing Alzheimer Disease Prediction With Large Language Model-Based Linguistic Feature Analysis: Development and Validation Study.

JMIR Med Inform. 2026 May 28;14:e86965.
Authors: Hsu MH, Hwang SY, Tsai YH, Chang YC, Liang CK, Chang CY
PubMed: 42208123
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Early α-Synuclein Heterodimerization Kinetics Predict Parkinson's Disease Onset.

J Phys Chem B. 2026 May 28; Epub 2026 May 28
Authors: Chaudhary S, Tammara V, Choudhary B, Das A
PubMed: 42207861
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Clinical presentation and diagnostic challenges of frontotemporal dementia in Brazil: A 15-year cohort study.

Neuroepidemiology. 2026 May 28;:1-23. Epub 2026 May 28
Authors: Queiroz EM, Couto CM, Ferreira AR, de Souza LC, Caramelli P
PubMed: 42207731
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Combined Olfactory Testing and Substantia Nigra Hyperechogenicity for Diagnostic Differentiation of Parkinson's Disease.

Eur Neurol. 2026 May 28;:1-21. Epub 2026 May 28
Authors: Kozel J, Augste E, Michalčová P, Šalounová D, Chalánková A, Bártová P, Szegedi I, Školoudík D
PubMed: 42207728
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RNA-binding protein diversity and NLS arginines regulate FUS mixing in mRNA-rich compartments.

Cell Rep. 2026 May 28;45(6):117430. Epub 2026 May 28
Authors: Valenti D, Joshi V, Pankivskyi S, Cai HH, Hamon L, Desforges B, Molliex A, Duez J, Bursztyka J, Davignon L, Maucuer A, Bollot G, Pastré D
PubMed: 42207631
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Bridging the gap in Alzheimer's therapy: strategic design and SAR evolution of coumarin-based hybrids as potent MTDLs.

RSC Adv. 2026 May 28;16(32):29631-29660. Epub 2026 Jun 1
Authors: El-Mokaddem OK, Elmasry GF, Mahmoud WR, Abdel Ghany LM
PubMed: 42239568
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Ex vivo T2*-weighted MRI and quantitative susceptibility mapping reflect spatial iron accumulation observed on histology in frontotemporal lobar degeneration.

Neurobiol Dis. 2026 May 27;:107461. Epub 2026 May 27
Authors: Prinse FA, Dopper EG, Giannini LA, Bulk M, Suidgeest E, Dijkstra K, van Buuren R, Goeman JJ, Dekker N, Staring M, Najac C, van Swieten JC, Seelaar H, van der Weerd L
PubMed: 42208872
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Evaluation of the neuroprotective effects of ergosterol in a streptozotocin-induced Alzheimer's disease rat model: Insights into anti-inflammatory and antioxidant mechanisms.

Exp Neurol. 2026 May 27;404:115853. Epub 2026 May 27
Authors: Kulkarni R, Kumari S, Sharma P, Dhapola R, Medhi B, HariKrishnaReddy D
PubMed: 42208720
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Age-related changes to brain energetics revealed by PET/MRI imaging.

Neuroimage Clin. 2026 May 27;50:104014. Epub 2026 May 27
Authors: Bevington CW, Dhaliwal S, McKenzie J, Stoessl AJ, Sossi V
PubMed: 42217474
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The irony of Parkinson's disease: Converging mechanisms of redox imbalance and ferroptosis.

Redox Biol. 2026 May 27;95:104239. Epub 2026 May 27
Authors: Cooke LE, Rocha E, DiMaio R, Straub AC, Fazzari M
PubMed: 42224992
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Integrated single-nucleus transcriptomics reveals stage-dependent neuronal and oligodendroglial remodeling in the Alzheimer's disease prefrontal cortex.

Biochem Biophys Res Commun. 2026 May 27;827:154047. Epub 2026 May 27
Authors: Lu C, Wang Y, Zhang Z, Zhang X
PubMed: 42224827
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A Rigid Supramolecular Solution to a Flexible Problem: A Multifunctional Calix[4]arene-Based Strategy to Prevent α‑Synuclein Toxicity.

ACS Cent Sci. 2026 May 27;12(5):669-683. Epub 2026 May 4
Authors: Dell'Accantera D, Piccinini G, Ciabini C, Felli IC, Volpi S, Marmiroli N, Sansone F, Ruotolo R
PubMed: 42221573
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Aquaporin‑4 polarization and glymphatic function in Alzheimer's disease: Mechanisms, modulators, and therapeutic strategies.

Pathol Res Pract. 2026 May 26;286:156564. Epub 2026 May 26
Authors: Huang B, Tang G
PubMed: 42208357
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Cortical changes in amyotrophic lateral sclerosis: comparing biomarkers of glymphatic flow and cortical excitability.

Clin Neurophysiol. 2026 May 26;190:2111949. Epub 2026 May 26
Authors: Pavey N, Tu S, Foster S, Geevasinga N, Calma A, Tsuji Y, Kiernan MC, Vucic S, Menon P
PubMed: 42229207
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Local Organization of Biological Membranes Modulates Tau-Lipid Interactions and Fibril formation.

JACS Au. 2026 May 25;6(5):3014-3026. Epub 2026 Apr 22
Authors: Piersson C, Lublin V, Duttine M, Khemtemourian L, Loquet A, Mathelié-Guinlet M, Fichou Y
PubMed: 42212095
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Valacyclovir Treatment in Mild Cognitive Impairment: The VALMCI Randomized Clinical Trial.

Alzheimer Dis Assoc Disord. 2026 May 25; Epub 2026 May 25
Authors: Devanand DP, Huey ED, Qian M, Wei R, Motter JN, Nedic L, Andrews HF, Deliyannides DA, Maayan L, Graff J, Deehan E, Acosta EP, Zanderigo F, Goldberg TE
PubMed: 42210804
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Multilingualism and cognitive reserve in older adults with, or at risk for, Alzheimer's disease: Evidence from resting-state functional connectivity.

Neurobiol Aging. 2026 May 25;166:50-57. Epub 2026 May 25
Authors: Coulter K, Dash T, Best T, Grant N, Ansaldo AI, Phillips NA, CIMA-Q and CCNA COMPASS-ND groups
PubMed: 42208339
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Molecular Mechanisms and Potential Biomarkers of Neuropsychiatric Disorders in Parkinson's Disease.

J Integr Neurosci. 2026 May 25;25(5):50055.
Authors: Owecki W, Futyma A, Kokorniak O, Szczech A, Słowikowski B, Poszwa J, Szymanowicz O, Goutor U, Jagodziński PP, Kozubski W, Dorszewska J
PubMed: 42216636
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Monitoring Lysosomal Viscosity in Hyperglycemia in Association with Ca2+ Homeostasis and Alzheimer's Disease Using a Fluorescent Zn-Metal Complex.

Chem Biomed Imaging. 2026 May 25;4(5):812-822. Epub 2025 Dec 8
Authors: Salam A, Mukherjee B, Sapkal GT, Nandi CK
PubMed: 42222568
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Neuroprotective Phytochemicals Targeting Amyloid and Tau Pathologies.

Curr Top Med Chem. 2026 May 25; Epub 2026 May 25
Authors: Ahmed I, Ansari YA, Parveen G, Shukla K, Bhise M, Singh S, Shaikh UP, Ahmed R, Ansari I, Kumar A
PubMed: 42220141
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Development, Optimization, and Characterization of Donepezil Hydrochloride-loaded Emulsomes with Nigella Sativa Oil for the Treatment of Alzheimer's Disease.

Curr Neurovasc Res. 2026 May 25; Epub 2026 May 25
Authors: Singh I, Dheek M, Usmani A, Chauhan SB, Sinha A
PubMed: 42220134
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Research Progress on Alzheimer's Disease with Classical Traditional Chinese Medicine Formulas.

Curr Drug Deliv. 2026 May 25; Epub 2026 May 25
Authors: Zhao J, Tian G, Qu Y, Liu Y, Wu W, Dai L, Zhang G, An F
PubMed: 42220121
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Modeling stimulus-induced stress responses in microglia-like cells using a commercial iPSC-dCas9-KRAB line.

Stem Cell Res. 2026 May 23;94:104017. Epub 2026 May 23
Authors: Saunders DM, Kearns NA, Ng B, Sultan F, Vyas H, Vialle RA, Clark EM, Tissera S, Xu J, Bennett DA, Wang Y
PubMed: 42214129
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Phosphodiesterase-5 Inhibitors in Neurodegenerative Diseases: A Path to Cognitive Rescue.

Curr Protein Pept Sci. 2026 May 22; Epub 2026 May 22
Authors: Shankar M, Tiwari P, Dubey S
PubMed: 42227483
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Fisetin and Neurodegeneration: From Preclinical Studies to Potential Clinical Applications.

CNS Neurol Disord Drug Targets. 2026 May 22; Epub 2026 May 22
Authors: Amin MA, Zehravi M, Sweilam SH, Darwin R, Gupta JK, Bhargav E, Dharmamoorthy G, Kumar VV, Rao AA, Suliman M, Periyasamy T, Emran TB
PubMed: 42227472
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Mitochondrial Dysfunction in Alzheimer's Disease: Beyond Energy Failure Toward a Pathogenic Nexus.

Curr Alzheimer Res. 2026 May 22; Epub 2026 May 22
Authors: Sridhar SK, Goudanavar P, Naveen NR
PubMed: 42227471
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Immunotherapeutic Advances in Alzheimer's Disease: The Convergence of Vaccinology and Nanoscience.

Curr Alzheimer Res. 2026 May 22; Epub 2026 May 22
Authors: Chellammal HS, Janakiraman AK, Ramachandran D, Chellappan RD, Sheikuduman MS, Janakiram MK, Boyina HK, Abdul Kader MS, Kannan SK, Sugavasi R
PubMed: 42227470
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Immunotherapeutic Innovations in Alzheimer's Disease: A Bibliometric Landscape of Global Research Trends and Evolution.

Curr Neuropharmacol. 2026 May 22; Epub 2026 May 22
Authors: Sun N, Liu Q, Wu P, Qing L, Zeng L, Tang J
PubMed: 42227404
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Neuro-navigated rTMS Targeting Left Angular Gyrus Promotes White-Gray Matter Remodelling to Improve Cognitive Function in Amnestic Mild Cognitive Impairment Patients: Evidence for Early Alzheimer.s Intervention.

Curr Neuropharmacol. 2026 May 22; Epub 2026 May 22
Authors: Yang Z, Hou X, Tan Y, Tang L, Ke Z, Hu Z, Ye Q, Meng H, Xu Y, Chen H
PubMed: 42227403
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Hypertension acts together with Aβ pathology in late-life to promote memory loss.

J Prev Alzheimers Dis. 2026 May 22;13(7):100579. Epub 2026 May 22
Authors: Da Ros LU, Ferrari-Souza JP, de Bastiani MA, Hauschild LA, Bellaver B, Ferreira PC, Leffa DT, Povala G, Lussier FZ, Chamoun M, Bezgin G, Benedet AL, Rahmouni N, Macedo AC, Blennow K, Ashton N, Zetterberg H, Borelli WV, Souza DO, Pascoal TA, Rosa-Neto P, Zimmer ER, Alzheimer’s Disease Neuroimaging Initiative
PubMed: 42172885
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Astrocytic Ferroptosis: An Integrative Hub Linking Metabolic Dyshomeostasis, Glial Crosstalk, and Neurodegeneration in Alzheimer's Disease.

Aging Dis. 2026 May 21; Epub 2026 May 21
Authors: Lu Z, Meng C, Ren X, Zhang S, Xu X, Hao S, Wang Q, Zhou D
PubMed: 42234965
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The Relationship between Antibody-mediated Immune Responses and Four Types of Neurodegenerative Diseases: A Mendelian Randomization Analysis.

Comb Chem High Throughput Screen. 2026 May 20; Epub 2026 May 20
Authors: Li J, Rong C, Wei Z, Wang X, Zhao D
PubMed: 42227498
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GLP-1 Receptor Agonists in Neuropathic Pain and Neurodegenerative Diseases: Mechanisms, Therapeutic Potentials, and Future Perspectives.

Curr Neuropharmacol. 2026 May 20; Epub 2026 May 20
Authors: Grasso M, Fidilio A, Varrasi S, Chiechio S
PubMed: 42227394
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Lactobacillus mucosae Reduces Neuronal Oxidative Stress in Alzheimer's Disease via the Regulation of CB2 Signaling.

J Integr Neurosci. 2026 May 19;25(5):48598.
Authors: Kong Y, Lv X, Yang Y, Li Q, Dai C, Lin X, Liu J, Li J
PubMed: 42216640
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Transmembrane Proteins in Neurodegeneration: Pathophysiology from Alzheimer's to Parkinson's Disease.

Curr Neuropharmacol. 2026 May 19; Epub 2026 May 19
Authors: Wu X, Zhang K, Kan C, Sheng S, Jing D, Han F, Sun X
PubMed: 42227398
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The Translational Potential of Oligodendrogenesis-Based Therapies for the Recovery of Neurological Diseases.

Curr Neuropharmacol. 2026 May 19; Epub 2026 May 19
Authors: Xie JX, Feng XS, He Y, Xiong XY, Tang Y
PubMed: 42227397
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Harnessing Neuronal Autophagy: Bridging Mechanistic Breakthroughs to Therapeutic Interventions.

Aging Dis. 2026 May 19; Epub 2026 May 19
Authors: Ahsan N, Khan FB, Basu J, Shariq M, Zaidi N, Khan RH, Raj R, Ayoub MA, Surolia A, Ashraf GM
PubMed: 42234962
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Amyloid status as a moderator of the association between physical activity and progression of Parkinson's disease.

Parkinsonism Relat Disord. 2026 May 18;148:108361. Epub 2026 May 18
Authors: Lee MJ, Pak K, Kim M, Lee JH
PubMed: 42214116
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Comment on "Explainable machine learning on clinical features to predict and differentiate Alzheimer's progression by sex: Toward a clinician-tailored web interface".

J Neurol Sci. 2026 May 17;488:126006. Epub 2026 May 17
Authors: Mangala N, Amistapuram K, Garapati RS
PubMed: 42235139
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Comment on "deep learning in neuroimaging for neurodegenerative diseases: State-of-the-art, challenges, and opportunities".

J Neurol Sci. 2026 May 14;488:126003. Epub 2026 May 14
Authors: D C S, Jagadish RM, D GK
PubMed: 42208250
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Friend or foe? Glial-vascular interactions in health and neurodegenerative disease.

Pharmacol Rev. 2026 May 12;78(4):100143. Epub 2026 May 12
Authors: McQuaid C, Sewell M, Montagne A
PubMed: 42229063
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Nonclinical characterization of ACP-204, a novel selective serotonin receptor subtype 2A receptor inverse agonist.

J Pharmacol Exp Ther. 2026 May 5;393(6):104932. Epub 2026 May 5
Authors: Burstein ES, Olsson R, Skold N, Jansen KE, Azar M, Sandiego C, Ridler K, Rabiner EA, Rhodes G, Dey PM, Pathak S
PubMed: 42208178
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Peak width of skeletonized mean diffusivity reveals early and multifactorial white matter injury across sporadic and Down syndrome-associated Alzheimer's disease.

Alzheimers Dement. 2026 May;22(5):e71507.
Authors: Morcillo-Nieto AO, Franquesa-Mullerat M, Zsadanyi SE, Arriola-Infante JE, Vaqué-Alcázar L, Rozalem-Aranha M, Parra JA, Zhao Z, Arranz J, Rodríguez-Baz Í, Maure-Blesa L, Videla L, Barroeta I, Del Hoyo Soriano L, Benejam B, Fernández S, Sanjuan Hernandez A, Pertierra L, Giménez S, Santos-Santos M, Dols-Icardo O, Illán-Gala I, Alcolea D, Belbin O, Lleó A, Carmona-Iragui M, Fortea J, Bejanin A
PubMed: 42212383
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Dementia diagnostic deserts: workforce and geographic inequities in the diagnostic pathway for cognitive impairment.

Health Aff Sch. 2026 May;4(5):qxag109. Epub 2026 May 27
Authors: Xu Z, Xue Y, Zheng Y, Wu B
PubMed: 42211564
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Curated set of tool compounds to probe PYK2 and FAK signaling in Alzheimer's disease.

Alzheimers Dement. 2026 May;22(5):e71508.
Authors: Weerawarna PM, Jesudason CD, Lobb KL, Mason ER, Gu X, Chu S, Richardson TI
PubMed: 42210035
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Multidirectional Effects of SARS-CoV-2 Coronavirus Proteins on Amyloid Transformation of Alpha-Synuclein.

Biochemistry (Mosc). 2026 May;91(5):836-846.
Authors: Stroylova YY, Konstantinova AV, Pozdyshev DV, Katrukha IA, Yousefi R, Muronetz VI
PubMed: 42219393
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A Conjugate of Aminoadamantane and Tetrahydro-γ-Carboline Inhibits Accumulation of Mutant α-Synuclein A53T in the Cellular Model of Proteinopathy.

Biochemistry (Mosc). 2026 May;91(5):789-799.
Authors: Burak MV, Pukaeva NE, Kryshkova VS, Kukharskaya OA, Nazdracheva MR, Pukhov SA, Rachenkov KA, Stavrovskaya AV, Fisenko VP, Kukharsky MS, Bachurin SO
PubMed: 42219390
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Behavioral characterization of olfactory, auditory, and motor deficits in 5×FAD mice.

J Vet Sci. 2026 May;27(3):e35.
Authors: Jang H, Lee S, Kim Y, Lee J, Kim JC, Kim JS, Park JH, Kim J, Son Y, Moon C
PubMed: 42225606
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A framework of digital biomarkers for neurodegenerative diseases.

Nat Rev Bioeng. 2026 Apr 23; Epub 2026 Apr 23
Authors: Nerrise F, Schütz N, Zhao Q, Gould C, Milstein A, Schulman K, Henderson VW, Landay J, Fei-Fei L, Lin FV, Adeli E
PubMed: 42239941
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Peptide-mediated delivery of an α-synuclein-targeting antisense oligonucleotide: Pharmacokinetics, safety, and central nervous system efficacy in a synucleinopathy model.

Drug Metab Dispos. 2026 Apr 17;54(6):100304. Epub 2026 Apr 17
Authors: Ahammad RU, Quach B, Salehi S, Rissman RA, Spencer B
PubMed: 42172871
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The underlap coefficient as a measure of a biomarker's discriminatory ability.

Biometrics. 2026 Apr 9;82(2)
Authors: Zhang Z, Inácio V, de Carvalho M
PubMed: 42216963
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A three-groups non-local model for combining heterogeneous data sources to identify genes associated with Parkinson's disease.

Biometrics. 2026 Apr 9;82(2)
Authors: Wixson TP, Shaby BA, Philtron DL, Lima LA, Wyman SK, Kaye JA, Finkbeiner S
PubMed: 42216962
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Neuroinflammation at the Crossroads of Neurodegeneration: The Roles of Microglia and Astrocytes in Parkinson's Disease, Alzheimer's Disease, and Multiple Sclerosis.

Neurosciences (Riyadh). 2026 Feb;31(2):89-107. Epub 2026 Apr 30
Authors: Almikhlafi MA
PubMed: 42238675
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Targeting amyloid-β in Alzheimer's disease: A critical analysis of clinical trials and their implications for drug development.

Iran J Basic Med Sci. 2026;21(2):531-543.
Authors: Han M, Li Z, Sun T, Xiao B, Zhang J, Liu S, Yang J, Ma J, Wang P
PubMed: 42212298
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Multispectral 7 Tesla MRI as a potential predictor of dopamine transporter deficiency in Parkinson's disease.

Imaging Neurosci (Camb). 2026;4 Epub 2026 May 26
Authors: Özer M, Egger B, Mennecke A, Nagel A, Zaiss M, Laun FB, Dörfler A, Winkler J, German A
PubMed: 42212222
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Comparison of long non-coding RNA NEAT1 expression, P53, and anti-oxidant factors between Alzheimer's patients and healthy individuals.

Iran J Basic Med Sci. 2026;29(4):598-604.
Authors: Yarahmadi S, Alidoust L, Saberi A, Khakpour-Taleghani B, Rostampour M, Jafari A
PubMed: 42212212
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The inhibition of the Aβ-ASC interaction site suppresses β-amyloid aggregation and cytotoxicity.

Front Immunol. 2026;17:1748748. Epub 2026 May 13
Authors: Zhao L, Xia X, Wang S, Liu R, Liu Z, Sun D, Yu X, Wu H
PubMed: 42212154
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Targeting microglia-mediated neuroinflammation in Alzheimer's disease: mechanisms and therapeutic approaches.

Front Immunol. 2026;17:1818802. Epub 2026 May 13
Authors: Li BF, Chen XY, Xie R, Mo YF, Wu YZ, Meng Y, Han XL, Chen MH, Peng YJ
PubMed: 42212127
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From muscle to brain: the mediating effect of vitamin D in the relationship between muscle loss and cognitive function in Alzheimer's disease.

Front Aging Neurosci. 2026;18:1630798. Epub 2026 May 13
Authors: Ma X, Yao L, Li F, Cui C, Wang E, Wang C, Zhao P, Weng X, Liu C, Liu S, Hu H
PubMed: 42212002
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Peripheral immune cells and glycation indices as potential diagnostic biomarkers in amyotrophic lateral sclerosis.

Exp Biol Med (Maywood). 2026;251:10987. Epub 2026 May 13
Authors: Yang X, Yang J, Li R, Dong H, Liu Y
PubMed: 42211895
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Cannabinoids in Alzheimer's disease: animal-human evidence and clinical pharmacology challenges.

Front Behav Neurosci. 2026;20:1833021. Epub 2026 May 13
Authors: Komedera M, Wojda U, Kiryk A
PubMed: 42211879
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Reliability and diagnostic performance of an automated MRI-based classifier compared with radiologists in Alzheimer's disease.

Front Neuroinform. 2026;20:1821249. Epub 2026 May 13
Authors: Zholshybek N, Abdurakhmanova E, Bimakhan A, Jumadilova D, Baiturlin Z, Almazan J, Bolla SR
PubMed: 42211832
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Metagenomic profiling of ocular surface microbiome alterations in patients with progressive supranuclear palsy-Richardson's syndrome.

Curr Res Microb Sci. 2026;10:100605. Epub 2026 May 14
Authors: Zhang R, Chen YK, Zhu QY, Feng RY, Liu H, Ma MM, Wang XJ
PubMed: 42211787
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Soft tissue changes in Dementia: A comprehensive systematic review.

Aging Brain. 2026;9:100159. Epub 2026 May 19
Authors: Pipitone F, Bernetti C, Gennaro GD, Greco F, Pugliese L, Zobel BB, Mallio CA
PubMed: 42211428
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Disrupted sleep-wake cycles and circadian rhythms in a Drosophila model of C9orf72-FTD.

Front Neurosci. 2026;20:1814072. Epub 2026 May 13
Authors: Eby KE, Shields BR, DelNegro I, Morley S, Snodgrass-Belt PA, Tipping M
PubMed: 42211284
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Prescribing of anti-dementia medications in primary care: A retrospective cohort study in 1489 English General Practices.

PLoS One. 2026;21(6):e0347921. Epub 2026 Jun 1
Authors: Morris C, Mok PL, Robinson DL, Allan L, Ashcroft DM, Blakeman T, Kontopantelis E
PubMed: 42224406
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Review of deep learning models for Alzheimer's disease detection: MRI-centric approaches and multimodal extensions.

Front Artif Intell. 2026;9:1707043. Epub 2026 May 15
Authors: Resen RD, Alzubaidi LS, Alwzwazy HA, Capel MI
PubMed: 42222839
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ApoE expression across the CNS: Who, What, Where, When, and How (much)?

Mol Neurodegener Adv. 2026;2(1):24. Epub 2026 Apr 17
Authors: Nolt GL, Lucido CC, Smith LM, Johnson LA
PubMed: 42222651
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Toothache and Alzheimer's Disease: A Mendelian Randomization Study of the NAAG-CD33 Neuroimmune Axis.

J Pain Res. 2026;19:603587. Epub 2026 May 26
Authors: Wang Q, Xie Y, Wu X, Jin S, Zhen W, Yu S, Sun Y, Sun W, Xu J, Zhang H
PubMed: 42222647
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The Impact of Brain Auditory Stimulation in the Gamma Band on Cognitive Functions in Early-stage Alzheimer Patients.

Basic Clin Neurosci. 2026;17(1):85-95. Epub 2026 Jan 1
Authors: Fanid LM, Beyrami M, Asl MJ, Nikzad B, Dadashi S, Zehtabi Z, Rasouli H
PubMed: 42222549
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Stage-stratified benefits of AI-radiomics PET in early Alzheimer's disease: a systematic review and meta-analysis.

Front Neurol. 2026;17:1771993. Epub 2026 May 15
Authors: Duan J, Yang M, Wang Y
PubMed: 42222534
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RNA editing in Parkinson's disease: emerging mechanisms, translational potential, and current challenges.

Front Neurosci. 2026;20:1850954. Epub 2026 May 15
Authors: Liu S, Wu A
PubMed: 42222368
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Overcoming the blood-brain barrier in Alzheimer's disease: translational perspectives on advanced drug delivery platforms.

Front Neurosci. 2026;20:1810486. Epub 2026 May 14
Authors: Roamcharern N, Yubolphan R
PubMed: 42222363
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Molecular mechanisms of autophagy-lysosomal pathway dysfunction in neurodegenerative diseases and therapeutic strategies for lysosomal repair: a review.

Front Neurosci. 2026;20:1819002. Epub 2026 May 15
Authors: Wang W, Meng X
PubMed: 42222362
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Genomic and proteomic conversion of brain ischemia to Alzheimer's disease.

Front Cell Dev Biol. 2026;14:1804251. Epub 2026 May 14
Authors: Pluta R, Ułamek-Kozioł M
PubMed: 42222332
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Association of baPWV and CD34+ progenitor-derived exosomal hsa_circ_0093884 with Alzheimer's disease: mechanistic insights into the miR-375/SIX4 axis.

Front Cell Dev Biol. 2026;14:1764767. Epub 2026 May 14
Authors: Chen Y, Huang Y, Gao B, Zhao Y, Wei L, Ye G, Chen S, Shi X, Wang R, Wang F
PubMed: 42222331
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Higher plasma omega-6 fatty acids are associated with lower dementia risk: evidence from NMR metabolomics and Alzheimer's disease polygenic risk in the UK Biobank.

Front Public Health. 2026;14:1816467. Epub 2026 May 14
Authors: Luo L, Gong S, Liu D, Zhou K
PubMed: 42221673
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The Integrative Personalized Functional Medicine Approach to Reverse Cognitive Decline: Academic Experience of the First 51 Patients Case Series.

Glob Adv Integr Med Health. 2026;15:27536130261452680. Epub 2026 May 27
Authors: Kogan M, Frame LA, Fahim Devin M, Prather C, Alchalabi T, Ashraf U, Darling Luczak B, Fine H, Ifateyo A, Ledenac M, Novak SS, Yakel J
PubMed: 42221535
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Geographic Variation in ADRD Prevalence and Mortality and Their Association with Social Vulnerability across US Counties: A Spatial Epidemiological Analysis Using NORC and CDC SVI Data.

Dement Geriatr Cogn Dis Extra. 2026;16(1):56-70. Epub 2026 Apr 2
Authors: Kyne D
PubMed: 42221521
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Beyond Inhibition: Rebalancing the Hsp90 Chaperone Network as a Therapeutic Strategy for Alzheimer's Disease.

Drug Des Devel Ther. 2026;20:602287. Epub 2026 May 26
Authors: Tang Z, Xie H, Xu Y, Zhou Z, Lu F, Wu Q, Liang W, Zhong M, Li S
PubMed: 42221352
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Diagnosis of Alzheimer's disease in asymptomatic individuals: a historical perspective.

Dement Neuropsychol. 2026;20:e2026487. Epub 2026 May 29
Authors: Nitrini R
PubMed: 42221153
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Oligodendrocyte dysfunction in neurodegenerative diseases: pathological features, underlying mechanisms and therapeutic targeting.

Front Aging Neurosci. 2026;18:1843643. Epub 2026 May 15
Authors: Liu Z, Liu J, Liang J, Meng C, Wang Q, Luo Y, Zhang H
PubMed: 42221032
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Shaping the cognitive reserve: the role of lifelong enrichment and education in the Alzheimer's disease continuum.

Front Aging Neurosci. 2026;18:1736047. Epub 2026 May 14
Authors: Serra L, Bonarota S, Di Domenico C, Caruso G, Rizzuti M, Sperati S, Tamigi FM, Di Lorenzo F, Ricci F, Laudadio M, Koch G, Giove F, Caltagirone C, Bozzali M
PubMed: 42221031
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Retraction: Repurposing food molecules as a potential BACE1 inhibitor for Alzheimer's disease.

Front Aging Neurosci. 2026;18:1875922. Epub 2026 May 14
Authors: Frontiers Editorial Office
PubMed: 42221028
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Retrotransposons as both "architects" and "saboteurs" in the nervous system.

Adv Genet. 2026;116:101-123. Epub 2025 Dec 2
Authors: Izquierdo-Useros N, Dierssen M, Clotet B, Elizalde-Torrent A, Carriba P
PubMed: 42219645
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[Glial Progenitor Cell Therapy Improves Mitochondrial Function in the Hippocampus of 5xFAD Mice, but Does Not Restore the Multiscale Structure of Behavioral Stress Response].

Mol Biol (Mosk). 2026;60(2):328-344.
Authors: Andreev AI, Neganova ME, Aleksandrova YR, Salikhova DI, Belousova EV, Shedenkova MO, Sudina AK, Maksimov YM, Orlova EA, Lapshina MA, Popov VS, Ahremenko EA, Goldshtein DV, Ustyugov AA, Nebogatikov VO
PubMed: 42227129
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[Immunoglobulin-Like Domains Are the Key to Understanding Amyloid Aggregation].

Mol Biol (Mosk). 2026;60(2):235-247.
Authors: Bobyleva LG, Vikhlyantsev IM, Bobylev AG
PubMed: 42227123
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Linguistic-cognitive intervention in a case of early-onset Alzheimer's disease.

Codas. 2026;38(3):e20250126. Epub 2026 Jun 1
Authors: Souza BA, Freitas MI
PubMed: 42233874
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Retrospective validation of SATURN, a public domain self-administered cognitive screening test.

Front Psychol. 2026;17:1801901. Epub 2026 May 18
Authors: Pasao KA, Florendo MN, Bissig D
PubMed: 42233077
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Inner retinal layer thickness reflects plasma biomarkers in preclinical Alzheimer's disease.

Front Med (Lausanne). 2026;13:1800287. Epub 2026 May 18
Authors: Chan JW, Wang Z, Xu E, Abboud I, Alhasany A, Xu S, Wu X, Astraea N, Jiang F, Hu ZJ
PubMed: 42232963
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Amygdala subregional atrophy across ATN-defined Mild Cognitive Impairment subgroups.

Front Neurosci. 2026;20:1791269. Epub 2026 May 18
Authors: Yuan Q, Xue C, Qi W, Liang X, Tang Y, Ruan Y, Xiao C
PubMed: 42232655
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From autophagy-lysosomal deficits to neurodegeneration in Niemann-Pick type C1 disease: implications for age-related neurodegenerative disorders.

Front Neurosci. 2026;20:1857866. Epub 2026 May 18
Authors: Kawachi Y, Kocak G, Korolchuk VI, Kataura T, Sarkar S
PubMed: 42232651
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Genetic and clinical investigation of insulin-degrading enzyme in Parkinson's disease within the Chinese Han population.

Front Neurosci. 2026;20:1827842. Epub 2026 May 18
Authors: Zheng H, Guo Y, Zhou L, Su Y, Cui X, Zhang S, Hu Z, Li S, Shi C, Xu Y, Mao C, Wang Y
PubMed: 42232650
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Scalable biological-cognitive profiling for Alzheimer's disease in the population.

Brain Commun. 2026;8(3):fcag168. Epub 2026 Jun 1
Authors: Lohi K, Aaltonen A, Herukka SK, Kokkola T, Kärkkäinen S, Urjansson M, FinnGen, Palotie A, Runz H, Kaprio J, Julkunen V, Saari T, Vuoksimaa E
PubMed: 42232612
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Mesial temporal shape asymmetry as a neuro-imaging correlate of epilepsy in mild cognitive impairment and dementia.

Brain Commun. 2026;8(3):fcag179. Epub 2026 May 18
Authors: Zawar I, Zhu S, Quigg M, Kapur J, Lam AD, Sarkis RA, D'Abreu A, Manning C, Fletcher PT
PubMed: 42232611
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Considering prediagnostic environmental modifiers of progression in amyotrophic lateral sclerosis.

BMJ Neurol Open. 2026;8(1):e001702. Epub 2026 May 29
Authors: Chalitsios CV, Turner MR
PubMed: 42232333
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Anti-inflammatory and immunomodulatory therapies are associated with reduced risk of age-associated neurodegenerative diseases: impact of sex and treatment duration.

Front Aging Neurosci. 2026;18:1818660. Epub 2026 May 18
Authors: Cortes-Flores H, Torrandell-Haro G, Brinton RD
PubMed: 42232224
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The role and mechanisms of AMPK in neurovascular unit injury in Parkinson's disease.

Front Aging Neurosci. 2026;18:1790159. Epub 2026 May 18
Authors: Liu B, Li N, Fan G, Guo Z, Wang K, Kong L
PubMed: 42232223
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Efficacy of transcranial magnetic stimulation for mild cognitive impairment: a systematic review and meta-analysis of randomized controlled trials.

Front Neurol. 2026;17:1788223. Epub 2026 May 18
Authors: Lin Y, Tao Y, He Z, Wang H, Zheng Y, Jin Y
PubMed: 42232172
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The NLRP3-α-Synuclein Circuit: A Core Driver and Therapeutic Target in Parkinson's Disease.

J Inflamm Res. 2026;19:597280. Epub 2026 May 28
Authors: Liu K, He Z, Zhang L, Wu YM, Xiao L
PubMed: 42232153
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Early proteomic signatures of Alzheimer's disease in the retina and brain of 3xTg-AD mice.

Front Cell Dev Biol. 2026;14:1827348. Epub 2026 May 18
Authors: Puja A, McNeel R, Xu R, Zhu S, Hansman D, Du J
PubMed: 42232055
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Artificial intelligence techniques for classification of Alzheimer's disease using neuroimaging data: a review.

Front Artif Intell. 2026;9:1748985. Epub 2026 May 18
Authors: Nibila Y, Sivagami M
PubMed: 42231879
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Overview of subjective cognitive decline in Brazil: a narrative review.

Dement Neuropsychol. 2026;20:e2025416. Epub 2026 Jun 1
Authors: Soares IS, Studart-Neto A, Brucki SM
PubMed: 42239695
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Cellular senescence in brain aging and neurodegeneration: from molecular mechanisms to translational opportunities.

Front Cell Neurosci. 2026;20:1805691. Epub 2026 May 19
Authors: Cantero-Fortiz Y, Butler C, Montalbán X, Boada M
PubMed: 42239645
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Node-level inference and score construction may overstate the diagnostic utility of cervical lymph node ultrasound in Alzheimer's disease.

Cereb Circ Cogn Behav. 2026;10:100545. Epub 2026 May 22
Authors: Liu Y
PubMed: 42238816
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Predicting amyloid status in Primary Progressive Aphasia using explainable artificial intelligence.

NPJ Dement. 2026;2(1):41. Epub 2026 Jun 1
Authors: Robertson C, Hochberg D, Quimby M, Wolff P, Dickerson BC, Rezaii N
PubMed: 42238807
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Telehealth-delivered multimodal mind-body intervention for mild cognitive impairment: a randomized feasibility trial toward scalable dementia prevention.

NPJ Dement. 2026;2(1):39. Epub 2026 Jun 1
Authors: Liu Y, Hodges S, Wu J, Siegel B, Velev A, Yan K, Ma L, Vangel M, Dickerson BC, Wong B, Kong J
PubMed: 42238806
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Lifting the Veil on Neuroinflammation in Parkinson's Disease: A Bibliometric Analysis.

J Inflamm Res. 2026;19:607710. Epub 2026 May 29
Authors: Dong S, Li X, Wang S, Gong Y, Wu L, Hu J, Chen X
PubMed: 42238771
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Clinicoanatomic localization of iron-rich gliosis in aphasic presentations of globular glial tauopathy.

Brain Commun. 2026;8(3):fcag169. Epub 2026 Jun 2
Authors: Irwin DJ, Emrani S, Ohm DT, Trotman W, Bahena A, Teunissen-Bermeo E, Sabatini P, Das SR, Mizsei G, Prabhakaran K, Ittyerah R, Coslett HB, Massimo L, Wolk DA, Detre JA, Gee JC, Lee EB, Yushkevich P, McMillan CT, Tisdall MD
PubMed: 42238478
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Predicting the Conversion From Mild Cognitive Impairment to Alzheimer's Disease Using Graph Frequency Bands and Functional Connectivity-based Features.

Basic Clin Neurosci. 2025 Nov;16(6):1113-1130. Epub 2025 Nov 1
Authors: Zamani J, Talesh Jafadideh A
PubMed: 42238754
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Detecting Mild Cognitive Impairment to Alzheimer's Disease Progression by fMRI Using Convolutional Neural Network and Long-short Term Memory.

Basic Clin Neurosci. 2025 Nov;16(6):1051-1066. Epub 2025 Nov 1
Authors: Ghafoori S, Shalbaf A
PubMed: 42238745
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