Alzforum - Papers of the Week: 24-30 Apr 2026

MMP9 as a shared immune-related gene in Alzheimer's and Huntington's diseases: a cross-tissue transcriptomic analysis.

Artif Cells Nanomed Biotechnol. 2026 Dec;54(1):316-331. Epub 2026 Apr 24
Authors: Li X, Zhang C, Ni H, Sun P, Ren J, Huang S
PubMed: 42030987
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Therapeutic effects of 40 Hz light stimulation on clinical and pathological features of Alzheimer's disease.

Dialogues Clin Neurosci. 2026 Dec;28(1):177-187. Epub 2026 Apr 26
Authors: Chou PS, Chien CF, Huang LC, Yang YH
PubMed: 42035365
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Convergent transcriptomic signature in iPSC-dopaminergic neurons of hereditary Parkinson's disease.

Life Sci Alliance. 2026 Jul;9(7) Print 2026 Jul
Authors: Kopylova IV, Ivanov AB, Eidelman LR, Zaitseva EN, Kulikova ED, Grehnyov DA, Bogomazova AN, Vigont VA, Kaznacheyeva EV, Lagarkova MA, Lebedeva OS, Olekhnovich EI
PubMed: 42031673
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Sex-dependent impact of Il6 deficiency in Parkinson's disease mice.

Genes Dis. 2026 Jul;13(4):101986. Epub 2025 Dec 15
Authors: Chen F, Duan Y, Wang M, Liu Z, Zhao J, Fan G, He Y, Dong H, Zhang X, Fang R, Zhang Y, Yan X, Shen C, Tang X, Ma Y, Yu M, Zhou R, Fei J, Huang F
PubMed: 42027807
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P2X7 receptor or TNAP genetic blockade prevents the reduction of neuronal CTCF detected in tauopathy.

Neuropharmacology. 2026 Jul 1;292:110948. Epub 2026 Mar 24
Authors: Aivar P, Sebastián-Serrano Á, Vincelle-Nieto Á, Collado-Cantero AC, Ouro-Corredera D, Soria-Tobar L, Reyes-Palomares A, Díaz-Hernández M
PubMed: 41881298
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Comparative Analysis of Deep Learning Techniques in Alzheimer's Disease Diagnosis: Trends, Challenges, and Future Directions.

MethodsX. 2026 Jun;16:103844. Epub 2026 Feb 21
Authors: Naik DR, Savyanavar DA
PubMed: 42027884
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Comment on "AlzStack: Forecasting early-onset Alzheimer's with an explainable AI system using multiple data balancing techniques".

Glob Epidemiol. 2026 Jun;11:100260. Epub 2026 Apr 20
Authors: Ailani T, Jauhari R, Rani A, Singh R
PubMed: 42051542
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Kaempferol Improves Alzheimer's Disease by Inhibiting Neuronal Ferroptosis via Activating GPX4/AKR1C3 Signaling Pathway.

Pharmacol Res Perspect. 2026 Jun;14(3):e70255.
Authors: Li L, Yang M, Tao J, Zhao Y, Zhao N, Sun S
PubMed: 42062795
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Cellular Senescence of Patient-derived Fibroblasts Reveals the Mid-old Stage as a Critical Window for Transcriptomic Signatures Linked to Alzheimer's Disease Biomarkers and Classification.

Clin Psychopharmacol Neurosci. 2026 May 31;24(2):353-367. Epub 2025 Dec 16
Authors: Cho YJ, Yoon S, Kim Y, Song HM, Nam YJ, Lee SH, Lee S, Shin D, Lee SM, Moon SY, Kim EJ, Cho SH, Kim BC, Choi SH, Seo SW, Kim JC, Park YJ, Kang HY, Lee SR, Hong S, Son SJ, Hong CH, Roh HW
PubMed: 42036745
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What Is the Potential Relevance of Hippocampal Area CA2 in Neurologic Disorders?

Neurology. 2026 May 26;106(10):e218096. Epub 2026 Apr 28
Authors: Benarroch E
PubMed: 42048628
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Phosphorylated TDP-43 Pathology in Skin and Muscle Tissue of Patients With Amyotrophic Lateral Sclerosis.

Neurology. 2026 May 26;106(10):e214940. Epub 2026 Apr 30
Authors: Nolano M, Provitera V, Caporaso G, Areniello AR, Borreca I, Stancanelli A, Senerchia G, Iuzzolino VV, Fasolino I, Vitale F, Ciccarelli G, Dell'Aversana D, Masciarelli F, Tozza S, Iodice R, Santoro L, Manganelli F, Dubbioso R
PubMed: 42060881
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Association of MRI-Visible Perivascular Spaces With Longitudinal Cognitive Decline Over a Decade.

Neurology. 2026 May 12;106(9):e214803. Epub 2026 Apr 24
Authors: Kohno K, Sun Y, LeFevre JD, Robb WH, Jackson TB, Liu D, Vyas Y, Sweely B, Pechman KR, Shashikumar N, Peterson A, Landman B, Davis LT, Hohman TJ, Jefferson AL
PubMed: 42030516
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Unveiling the glymphatic system's role in brain aging: A comprehensive biomarker and modifiable intervention target.

Proc Natl Acad Sci U S A. 2026 May 5;123(18):e2516601123. Epub 2026 Apr 27
Authors: Fang Y, Luo W, Huang H, Ran L, He Y, Cheng C, Yao Y, Hou Y, Zheng H, Pan D, Xu S, Luo X, Qin T, Hao X, Lu F, Wang W, Wang M
PubMed: 42044335
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Exploring PrPC unfolding as a critical step preceding its refolding in the context of PrPSc propagation.

Proc Natl Acad Sci U S A. 2026 May 5;123(18):e2529837123. Epub 2026 Apr 29
Authors: Sabzehei S, Rigoli M, Cacheiro R, Díaz-Arias I, Eraña H, Lago RP, Guerra A, Rezaei H, Castilla J, Biasini E, Sánchez-Pedregal VM, Martín-Pastor M, Requena JR
PubMed: 42054361
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Corrigendum to "The role of cannabinoid ligands in neurodegenerative diseases: Emerging anti-inflammatory, immunomodulation and disease-modifying perspectives" [Pharmacol. Res. 227 (2026) 108185].

Pharmacol Res. 2026 May;227:108206. Epub 2026 Apr 23
Authors: Baldasso GM, Paes RS, Moreira AG, Salvadori SG, Limberger C, Roviezzo F, Capasso R, Dutra RC
PubMed: 42031635
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Changes in Regional T1/T2-Weighted Ratio Index in Patients With Semantic Dementia.

Psychogeriatrics. 2026 May;26(3):e70170.
Authors: Ota M, Koshibe Y, Kitabatake A, Takahashi T, Nemoto K, Arai T
PubMed: 42029577
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The Myokine Irisin Represents an Indirect Pathway Linking Exercise to Hippocampal Subfields Relevant to Alzheimer's Disease and Neurogenesis.

Aging Cell. 2026 May;25(5):e70497.
Authors: Pace T, Levenstein JM, Quigley BL, Houston R, Bouças AP, Andrews SC
PubMed: 42033046
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Simultaneous Representation Learning of Multi-Omics and Clinical Outcome Data via a Supervised Knowledge-Guided Bayesian Factor Model.

Stat Med. 2026 May;45(10-12):e70570.
Authors: Zhang Q, Chang C, Jin C, Shen L, Long Q
PubMed: 42035335
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Structural Volumetric Alterations in Parkinson's Disease With Mild Cognitive Impairment.

Brain Behav. 2026 May;16(5):e71410.
Authors: Hu J, Lei P, Zhang J, Wu Q, Zhang Z, Zhu X, Li B
PubMed: 42043968
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GPND-AI NULISA: A 15-Protein AI classifier for diagnosis and co-pathology profiling across neurodegenerative diseases.

Alzheimers Dement. 2026 May;22(5):e71420.
Authors: Xu Y, Denkinger MN, Liu M, Gong K, Chen Y, Western D, Timsina J, Cheng Y, Xie Y, Mu R, Budde J, Beach TG, Serrano GE, Reiman EM, Singh A, Alfradique-Dunham I, Benzinger TL, Schindler SE, Morris JC, Holtzman DM, Perlumtter JS, Snider BJ, Campbell MC, Kotzbauer PT, Ashton NJ, Cruchaga C
PubMed: 42050390
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Designing a communication strategy to promote Alzheimer's disease prevention: The CULTIVAMENTE campaign.

Alzheimers Dement. 2026 May;22(5):e71448.
Authors: Aravena JM, Castro H, Poblete R, Saavedra G, Briceño R, Torres W, Vecchi M, Budinich M, Fuentes P, Albala C, Levy BR
PubMed: 42050370
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Peripheral vascular function, including endothelium-dependent measures, and dementia risk: The Framingham Heart Study.

Alzheimers Dement. 2026 May;22(5):e71396.
Authors: Tao Q, Han J, Ang TF, Hou L, Liu C, Murabito JM, Lunetta KL, Mez J, Alosco ML, Stein TD, Zhang X, Au R, Farrer L, Palmisano JN, Hamburg NM, Qiu WQ
PubMed: 42050369
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Reduced risk of dementia with recombinant zoster vaccine in US adults age 65 or older.

Alzheimers Dement. 2026 May;22(5):e71407.
Authors: Dos Reis S, Tran P, Mohanty K, Amill-Rosario A, Johnson A, Ryan K, Alsdurf H, Oraichi D, Yun H
PubMed: 42050365
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Identification of Alzheimer's disease subtypes and biomarkers from human multi-omics data using subspace merging algorithm.

Alzheimers Dement. 2026 May;22(5):e71292.
Authors: Song Z, Huang X, Jannu AJ, Johnson TS, Zhang J, Huang K
PubMed: 42056682
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Bibliometric analysis of Alzheimer's and dementia research in Latin America.

Alzheimers Dement. 2026 May;22(5):e71395.
Authors: Vazquez-Guajardo M, Mimenza-Alvarado AJ, Martinez-Zamora CA, Lee A, Padilla Solis OA, Parodi JF, Custodio Capuñay NS, Aguilar-Navarro SG
PubMed: 42056639
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Activities of daily living and their neural correlates across the Alzheimer's disease continuum: Evidence from a Latin American cohort.

Alzheimers Dement. 2026 May;22(5):e71445.
Authors: Henríquez F, Riquelme P, Forno G, Migeot J, Henríquez R, Lillo P, Thumala-Dockendorff D, Okuma C, Campo CG, Hornberger M, Aboitiz F, Slachevsky A
PubMed: 42056392
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Characterizing circadian rest-activity rhythm patterns across Alzheimer's disease continuum in Down syndrome.

Alzheimers Dement. 2026 May;22(5):e71409.
Authors: Giménez S, Vaqué-Alcázar L, Clos S, Benejam B, Carmona-Iragui M, Maure-Blesa L, Videla L, Zhu N, Altuna M, Arranz J, Barroeta I, Rodríguez-Baz Í, Bejanin A, Bueno A, Fernandez S, Del Hoyo Soriano L, Pertierra L, Alcolea D, Miller B, Grinberg LT, Ruiz J, Lisgaras CP, Wu HT, Lleó A, Osorio RS, Blessing EM, Fortea J
PubMed: 42056071
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RETRACTION: The 12-15-Lipoxygenase is a Modulator of Alzheimer's-Related Tau Pathology In Vivo.

Aging Cell. 2026 May;25(5):e70524.
Authors:
PubMed: 42053514
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Clinically Deployable Handwriting Biomarkers of Parkinson's Disease via Multiscale Attention and Bayesian-Genetic Optimization.

Brain Behav. 2026 May;16(5):e71457.
Authors: Rezaee K, Fakhrabadi AK
PubMed: 42050861
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Development and validation of MethylCog, a blood DNA methylation proxy for cognition.

Alzheimers Dement. 2026 May;22(5):e71421.
Authors: O'Shea DM, Wang L, Lukacsovich D, Dhanekula D, Zhang W, Galvin C, Joshi M, Besser L, Rundek T, Galvin JE
PubMed: 42062774
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Sex differences in Alzheimer's.

Nat Immunol. 2026 May;27(5):885.
Authors: Houston S
PubMed: 42062506
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When Viruses Talk through Extracellular Vesicles: a New Perspective on Sars-Cov-2-Induced Neurodegeneration.

J Extracell Vesicles. 2026 May;15(5):e70272.
Authors: Bawne G, Coenen L, Nutma E, Middeldorp J, Lorenowicz MJ
PubMed: 42060826
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RETRACTION: Antileukotriene Therapy by Reducing Tau Phosphorylation Improves Synaptic Integrity and Cognition of P301S Transgenic Mice.

Aging Cell. 2026 May;25(5):e70523.
Authors:
PubMed: 42060510
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Stress Accelerates Depressive-Like Behaviors through Increase of Notch2 Expression in N141I Mutation Presenilin-2 Transgenic Mice.

Biomol Ther (Seoul). 2026 May 1;34(3):544-555. Epub 2026 Apr 30
Authors: Yoo SS, Gu SM, Nam KT, Choi JS, Lee YS, Yeo IJ, Yu JE, Kim S, Lee DW, Ham HJ, Chang JY, Yun J, Son DJ, Han SB, Hong JT
PubMed: 42059026
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Real-world comparison of brain [18F]FDG-PET imaging with CSF Alzheimer's disease biomarkers in a tertiary memory clinic setting.

EClinicalMedicine. 2026 May;95:103910. Epub 2026 Apr 20
Authors: Rabaneda-Lombarte N, Ferrari-Souza JP, Celedon J, Zimmer ER, Dickerson BC, Arnold SE, Kivisäkk P, Serrano-Pozo A
PubMed: 42058506
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Prebiotic intervention changes host and microbe proteomes in plasma extracellular vesicles of Parkinson's disease.

Sci Rep. 2026 Apr 30; Epub 2026 Apr 30
Authors: Sharma D, Voigt RM, Hall DA, Cantu-Jungles TM, Shaikh M, Engen PA, Jones J, Li S, Hamaker BR, Forsyth CB, Bishehsari F, de Menezes EG, Norris PJ, Goetz CG, Keshavarzian A
PubMed: 42062487
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Characterizing the metabolomes of microglia, astrocytes and neurons in ageing and Alzheimer's brains.

Nat Cell Biol. 2026 Apr 30; Epub 2026 Apr 30
Authors: Yu J, Li F, Chen XJ, Mou C, Yao D, Bi Z, Chen X, Du L, Feng Z, Zhang X, Yu X, Zacharias LG, DeBerardinis RJ, Zhang L, Li Z, Luo B, Hu XL, Ge WP
PubMed: 42062482
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Correction: Post-mortem human Alzheimer's brain metallome depends on Braak stages and brain regions.

Sci Rep. 2026 Apr 30;16(1)
Authors: Parra-Martínez C, Callejón-Leblic B, Rodrigo-Lara H, Fernández-Vega I, Guerrero-Márquez MC, Rábano A, García-Barrera T
PubMed: 42062336
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Innovation in Alzheimer's disease needs more than pharmaceutical solutions.

BMJ. 2026 Apr 30;393:s788.
Authors: Brayne C, Richard E
PubMed: 42061951
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The World Federation of Neurology Specialty Group in ALS/MND: toward strategic partnership and new frontiers.

Amyotroph Lateral Scler Frontotemporal Degener. 2026 Apr 30;:1-3. Epub 2026 Apr 30
Authors: Kiernan MC, Genge A, Grosskreutz J, Kuwabara S, Lillo P, Rosenfeld J, Cummings C
PubMed: 42060866
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The Development of the Digital Cognitive Screen, Parkinson's Cognition (Par-Cog).

Appl Neuropsychol Adult. 2026 Apr 30;:1-12. Epub 2026 Apr 30
Authors: Craig SN, Dempster M, Curran D, Lyttle N
PubMed: 42060784
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Tracking the turning point in Alzheimer's disease.

Science. 2026 Apr 30;392(6797):468-469. Epub 2026 Apr 30
Authors: De Strooper B, Zetterberg H
PubMed: 42060745
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Multi-view Hilbert Curve-based Hierarchical Information Aggregation for Incomplete Multimodal Alzheimer's Disease Diagnosis.

IEEE Trans Med Imaging. 2026 Apr 30;PP Epub 2026 Apr 30
Authors: Liu C, Que Y, Wong WK, Liu Y, Luo X
PubMed: 42060436
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Factors influencing accelerated progression in behavioral variant frontotemporal dementia.

J Neurol. 2026 Apr 30;273(5)
Authors: Split M, Kunicki ZJ, Ross D, Keszycki R, Prieto S, Manoochehri M, De Vito AN, Appleby B, Hales CM, Onyike C, McMillan CT, Clark D, Irwin D, Knopman D, Galasko DR, Wint D, Roberson ED, Léger GC, Hsiung GR, Heuer HW, Rosen HJ, Grant IM, Mackenzie IR, Litvan I, Kornak J, Kwan J, Rascovsky K, Domoto-Reilly K, Massimo L, Honig LS, Forsberg LK, Tartaglia MC, Mendez MF, Graff-Radford N, Ghoshal N, Ljubenkov P, Darby RR, Barmada S, Weintraub S, Lee S, Sullivan AC, Boxer A, Staffaroni AM, Snyder A, Bozoki A, Pascual B, Dickerson BC, Boeve BF, Huey ED, Barker M
PubMed: 42060164
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Olfactory dysfunction as a marker of neurodegenerative disease in older adults.

Aging Clin Exp Res. 2026 Apr 30; Epub 2026 Apr 30
Authors: Klíčová K, Menšíková K, Šebelová D, Polčáková P, Kaleta M, Cook SE, Ildžová Z, Satke L, Zimek D, Kaňovský P
PubMed: 42060155
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Outcome associations of CSF total tau in suspected non-Alzheimer pathophysiology.

J Neurol. 2026 Apr 30;273(5)
Authors: Briel N, Borsi M, Schreiner SJ, Schneider T, Loosli SV, Togni C, Carta MC, Loosli J, Köpp A, Ziegler M, Nicoletti T, Weller M, Felbecker A, Weiss T, Jung HH
PubMed: 42060129
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Neural Stem Cell-Derived Extracellular Vesicles: The Next Frontier in Neurological and Neurodegenerative Diseases.

Stem Cell Rev Rep. 2026 Apr 30; Epub 2026 Apr 30
Authors: Marei HE, Cenciarelli C
PubMed: 42060081
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A Multimodal Latent Severity Axis for Alzheimer's Disease: Probabilistic PCA, Bayesian Trajectories, and Stage-Aware Timing Effects.

Neurol Ther. 2026 Apr 30; Epub 2026 Apr 30
Authors: Haji B, Tahami Monfared AA, Alzheimer’s Disease Neuroimaging Initiative
PubMed: 42060036
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Uncovering Spatiotemporal and Functional Dynamics of Long Non-coding RNAs During Alzheimer's Progression in the Human Brain at Single-Cell Resolution.

Mol Neurobiol. 2026 Apr 30;63(1)
Authors: de Carvalho A, Mamede I, Sanches L, Juvenal G, Viero FT, Franco GR, Tang Y, Reis EM, Ulrich H
PubMed: 42060014
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Subjective Sleep Traits and Cognition Across Mid- to Late-Adulthood: A Cross-Sectional Study of Gene-Environment Interplay.

Sleep. 2026 Apr 30; Epub 2026 Apr 30
Authors: Vo-Eckerle TT, Gillespie NA, Christensen K, Finkel D, Kremen WS, Nygaard M, Sachdev PS, Thalamuthu A, Reynolds CA
PubMed: 42059651
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Integrated multi-omics analysis reveals gut dysbiosis and altered energy metabolism in Chinese ALS patients.

Microbiol Spectr. 2026 Apr 30;:e0060926. Epub 2026 Apr 30
Authors: Ma X, Jiang Z, Yang T, Zhang H, Lu W, Liu K, Fan X, Yang G, Wu S
PubMed: 42059647
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Optimization and Characterization of SHIP1 Ligands for Cellular Target Engagement and Activity in Alzheimer's Disease Models.

J Med Chem. 2026 Apr 30; Epub 2026 Apr 30
Authors: Jesudason CD, Rangel-Barajas C, Beach CJ, Beck DE, Caballero-Floran IH, Clayton WB, Da Silva L, David JC, Doolen S, Faulkner AN, Hamdani AK, Huhe H, Huynh K, Imhoff RD, Javens-Wolfe J, Mason ER, Moussaif M, Singhal K, Soni DM, van Buuren-Milne M, Williams SP, Angus SP, Chu S, Dage JL, Hipskind PA, Johnson TS, Kaddurah-Daouk R, Lamb BT, Meikle PJ, Mesecar AD, Palkowitz AD, Quinney SK, Sukoff Rizzo SJ, Oblak AL, Richardson TI
PubMed: 42059452
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Neuro-reparative potential of hyperbaric oxygen therapy in animal models of Alzheimer's and Parkinson's diseases: systematic review and meta-analysis.

Neurodegener Dis Manag. 2026 Apr 30;:1-9. Epub 2026 Apr 30
Authors: Radhakrishnan A, Dutta D, Saha M, Venkatakrishnan S, Kulkarni A, Chandrachari KP, Salins PC, Suresh A
PubMed: 42057743
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The amplification of α-synuclein amyloid fibrils.

Biochem Soc Trans. 2026 Apr 30;54(4):427-435.
Authors: Buell AK
PubMed: 42057656
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Brain aging and neurodegenerative diseases: physiological insights from anti-aging protein Klotho.

Korean J Physiol Pharmacol. 2026 Apr 30; Epub 2026 Apr 30
Authors: Do PA, Nguyen HS, Cha SK
PubMed: 42057473
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Natural Products for Alzheimer's Disease: A New Twist Impacting Ferroptosis.

Am J Chin Med. 2026 Apr 30;:1-25. Epub 2026 Apr 30
Authors: Yi Y, Jia P, Xie P, Peng X, Zhu X, Yin S, Yan C, Yu G
PubMed: 42057258
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Variant-to-function dissection of the 17q21.31 locus resolves ANKRD1 as a convergent regulatory target.

BMC Med Genomics. 2026 Apr 30; Epub 2026 Apr 30
Authors: Olaoye OJ, Farrow SL, Cooper AA, Nyaga DM, O'Sullivan JM
PubMed: 42057133
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The Dementias Platform UK PET/MR harmonisation and test-retest study: assessment of PET repeatability and reproducibility across the national network.

Eur J Nucl Med Mol Imaging. 2026 Apr 29; Epub 2026 Apr 29
Authors: Markiewicz PJ, Thompson G, Wardlaw JM, Wimberley C, Ritchie C, Taylor JP, Brooks D, Maxwell R, Firbank M, Hoggard N, Su L, Wild J, Hillel P, Rhodes-Bradford V, Parkes LM, O'Brien JT, Carter SF, Aigbirhio FI, Fryer T, Matthews PM, Malhotra P, Grey G, Hallett W, Ocal D, Dickson JC, De Vita E, Thomas DL, Fox NC, Krokos G, Mackewn JE, Marsden P, Hammers A, Herholz K, Barkhof F, Matthews JC
PubMed: 42050257
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CD33 Isoform Splicing Dysregulation: A Molecular Determinant of Microglial Dysfunction in Alzheimer's Disease Pathology.

Mol Neurobiol. 2026 Apr 29;63(1)
Authors: Li XY, Zhang Y, Ran Z, Luo JX, Yu XQ, Lu MH
PubMed: 42050212
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Unveiling an ALS Blood Transcriptomic Signature: A Machine Learning Classifier Distinct from Neurodegenerative Controls.

Neuroinformatics. 2026 Apr 29;24(2)
Authors: Gascón E, Calvo AC, Zaragoza P, Osta R
PubMed: 42050008
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Electrochemical detection of miRNA-128 in Alzheimer's disease using (3-aminopropyl) triethoxysilane and citrate-capped green-synthesized silver nanoparticles.

Mikrochim Acta. 2026 Apr 29;193(5)
Authors: Rani S, Khatri A, Devi S, Mahesh KV, Sandhir R, Prabhakar N
PubMed: 42056645
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Author Correction: UK Biobank at 20 - a growing, global resource for dementia research.

Nat Rev Neurol. 2026 Apr 29; Epub 2026 Apr 29
Authors: Matthews PM, Allen NE, Debette S, Doherty A, Douaud G, Duff EP, Elliott P, Fulda ES, Ilina A, Le Grand Q, Lewandowski AJ, Mahoney R, Miller K, Rodriguez C, Rutter MK, Sandor C, Sims R, Smith SM, Wang C
PubMed: 42056554
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PET-guided Assessment of Amyloid Clearance and Outcomes in a Real-World Cohort of Patients with Alzheimer Disease undergoing Anti-Amyloid Therapy.

AJNR Am J Neuroradiol. 2026 Apr 29; Epub 2026 Apr 29
Authors: Ivanidze J, Gardella J, Olson A, Sun SM, Thomas C, Wong OL, Intorcia B, Moirano J, Tanavde V, Gershon B, Pahlajani S, Roytman M, Nordvig A, Lin M, Hamed M, Alport A, Salgado M, Keil S, O'Dwyer E, Lantos J, Huicochea Castellanos S, Ebani EJ, Agee M, Fink ME, Osborne JR, Chiang GC, Blum S
PubMed: 42055956
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Drug repositioning in Alzheimer's disease: a vascular perspective targeting the NO-cGMP pathway.

Eur J Hosp Pharm. 2026 Apr 29; Epub 2026 Apr 29
Authors: Caíña López S, Portela Sotelo A, Vázquez-Gómez S
PubMed: 42055793
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Low overlap of plasma and CSF protein quantitative trait loci affects protein discovery for neurological disease.

Sci Transl Med. 2026 Apr 29;18(847):eadz2016. Epub 2026 Apr 29
Authors: Western D, Yang C, Timsina J, Liu M, Wang C, Campbell MC, Kotzbauer P, Perlmutter JS, Schindler SE, Morris JC, Holtzman DM, Alvarez I, Pastor P, Wyss-Coray T, Marquié M, Cano A, Sung YJ, de Rojas I, Ruiz A, Budde J, Fernandez MV, Tarawneh R, Ibanez L, Cruchaga C
PubMed: 42054495
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A Polypharmacology-Driven Approach to Alzheimer's Disease and Tauopathies: Rational Design, Synthesis and Characterization of Amino-Pyrazole-Based Multikinase (GSK-3β/FYN-α/DYRK1A) Inhibitors.

J Med Chem. 2026 Apr 29; Epub 2026 Apr 29
Authors: Demuro S, Russo D, Penna I, Grabska S, Grabski H, Dalle Vedove A, Valeri A, Sauvey C, Ottonello G, Summa M, Bertozzi SM, Ortega J, Bertorelli R, Storici P, Girotto S, Cruciani G, Di Martino RM, Abagyan R, Cavalli A
PubMed: 42054438
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The association between neurofilament light chain and cognitive function: a UK Biobank cohort study.

J Neurol. 2026 Apr 29;273(5)
Authors: Niu Y, Chen Y, Li Y, Du Y, Li S, Gao T, Xu X
PubMed: 42053837
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Unravelling the spatiotemporal dynamics of amyloid- -induced astrocyte-neuron network model in Alzheimer's disease.

J Math Biol. 2026 Apr 29;92(5)
Authors: Pradhan D, Upadhyay RK
PubMed: 42053826
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Evolving 10-year epidemiological landscape of amyotrophic lateral sclerosis (ALS) in Ceará, Brazil.

Amyotroph Lateral Scler Frontotemporal Degener. 2026 Apr 29;:1-7. Epub 2026 Apr 29
Authors: Fernandes JM, Dutra Junior AM, Thomas FP, Gondim FA
PubMed: 42053785
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Therapeutic Mechanisms of Stem Cell-Derived Exosomes for Neurological Disorders: An Overview.

Mol Neurobiol. 2026 Apr 29;63(1)
Authors: Lin C, Qi L, Gao X, Hu L, Qian B, Deng Y, Zhou C, Wang C, Liu G, Ding Q, Lin Z, Zhu X, Zhang M
PubMed: 42053700
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Diagnosis of Alzheimer's disease based on particle swarm optimization EEG signal channel selection and gated recurrent unit.

Comput Methods Biomech Biomed Engin. 2026 Apr 29;:1-16. Epub 2026 Apr 29
Authors: Shen X, Ding L, Li X, Gu L, Yang J
PubMed: 42053612
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Effect of repeated hot water immersion on cognitive performance, cerebrovascular function, sleep and biomarkers of neurodegeneration in older adults.

Exp Physiol. 2026 Apr 29; Epub 2026 Apr 29
Authors: Piccolo DD, Corbett J, Costello JT, Williams TB, James TJ, Shute JK, Alnajjar MG, Hudson LC, Marsh PA, Praskacova V, Mayes HS, Tipton M, Perissiou M, McNarry MA, Mackintosh KA, Saynor ZL, Shepherd AI
PubMed: 42053510
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Real-world performance of Lumipulse G plasma p-tau217: a six-month experience of a specialized clinical neurochemistry laboratory.

Clin Chem Lab Med. 2026 Apr 29; Epub 2026 Apr 29
Authors: Arslan B, Gobom J, Simrén J, Fahlén H, Andreasson U, Andrea Lessa Benedet, Kvartsberg H, Zetterberg H
PubMed: 42053135
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Multi-target approaches to prion disease Drug discovery: a status update.

Expert Opin Drug Discov. 2026 Apr 29; Epub 2026 Apr 29
Authors: Nikolić L, Legname G
PubMed: 42053126
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Comparative transcriptomics reveal molecular convergence and divergence in parkinsonian disorders.

Brain. 2026 Apr 29; Epub 2026 Apr 29
Authors: Geithus S, Flønes IH, Alves G, Tysnes OB, van de Berg WD, Pihlstrøm L, Nido GS, Tzoulis C
PubMed: 42052893
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APOE shifts the tipping point: addressing pathological heterogeneity in Alzheimer's disease trials.

Brain. 2026 Apr 29; Epub 2026 Apr 29
Authors: Tosun D
PubMed: 42052872
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The caregiver's inventory neuropsychological diagnosis dementia (CINDD) as useful tool in differential diagnosis of dementias.

Clin Neuropsychol. 2026 Apr 29;:1-15. Epub 2026 Apr 29
Authors: Blundo C, Ricci M
PubMed: 42051176
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Multi-Target Neuroprotective Compound Exhibits EAAT2-Modulating and Alzheimer's Pathology-Attenuating Effects in In Vitro and In Vivo Models.

ACS Chem Neurosci. 2026 Apr 29; Epub 2026 Apr 29
Authors: Hacımüftüoğlu A, Saraçoğlu N, Saffour S, Abad N, Kesgun Y, Zegheb N, Gundeger E, Yeşilyurt F, Ataş MN, Bati-Ayaz G, Altunlu Ö, Çınar B, Yörük MA, Okkay U, Özkaraca M, Ateş O, Taghizadehghalehjoughi A, Lafzi F, Türkez H
PubMed: 42051019
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Endogenous Ecotropic Murine Leukemia Virus Promotes Prion Pathogenesis in Senescence-accelerated Mice.

Exp Neurobiol. 2026 Apr 29; Epub 2026 Apr 29
Authors: Choi MW, Mostafa MN, Kim MJ, Jang B, Choi MJ, Kim JI, Kim YS, Choi EK
PubMed: 42050988
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Amyloid pathology and modifiable risk factors in cognitive decline among cognitively unimpaired older adults.

J Prev Alzheimers Dis. 2026 Apr 29;13(6):100574. Epub 2026 Apr 29
Authors: Hsu YH, Liang CK, Chou MY, Davidson J, Wang YC, Nalls MA, Ferrucci L, Cookson M, Iwaki H
PubMed: 42060990
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Donepezil increases angiogenic potential in patients with Alzheimer's disease.

J Alzheimers Dis. 2026 Apr 29;:13872877261444020. Epub 2026 Apr 29
Authors: Lee M, Kim M
PubMed: 42057407
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Return of Individual Research Information in the Parkinson's Progression Markers Initiative.

Ann Neurol. 2026 Apr 29; Epub 2026 Apr 29
Authors: Tropea TF, Brodkin K, Brumm MC, Carley JK, Destro C, Flagg E, Heathers LE, Henry B, Lemon LP, Kuhl MM, McMahon BA, Miller M, Myers H, Stanley CE Jr, Talarico JM, Pico C, Chahine LM, Siderowf A, Marek K, Foroud T, Parkinson's Progression Markers Initiative
PubMed: 42057343
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Performance of plasma pTau217, pTau181 and their ratios to Aβ42 in detecting Aβ pathology using a China-developed direct chemiluminescence assay.

Alzheimers Res Ther. 2026 Apr 29; Epub 2026 Apr 29
Authors: Yang D, Ke Z, Chen N, Yue L, Chen S, Jiang M, Hu Z, Xie C, Zhu W, Xu J, Yu L, Tang L, Zhao H, Dong J, Li C, Chen G, Luo B, Zhang J, Xu Y
PubMed: 42057058
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PTP1B in astrocytes drives pathogen-induced neurodegeneration.

J Neuroinflammation. 2026 Apr 29; Epub 2026 Apr 29
Authors: He Z, Xing Y, Gu J, Xu D, He P, Lin X, Cui W, Lv H, Ding H, Sui K, Hao W, Zheng Y, Yang X, Huang X, Yin K, He C, Zheng K, Yu Y, Pan W
PubMed: 42057007
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Rational Design of a Multivalent RNA Combining Structural Motifs Tailored to Multiple Domains of Fused in Sarcoma for Potent Inhibition of Aggregation.

Chembiochem. 2026 Apr 28;27(8):e202500568.
Authors: Kuroiwa N, Sakaue F, Miura M, Go A, Iwase R, Iwata Hara R, Sanjo N, Ui-Tei K, Yokota T
PubMed: 42029573
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Molecular Dynamics Study of the Binding of Cationic, Anionic, and Neutral Luminescent Conjugated Ligands to the Alzheimer Folds of Aβ(1-42) and Tau Fibrils.

Chembiochem. 2026 Apr 28;27(8):e202500902.
Authors: Todarwal Y, Linares M, Norman P
PubMed: 42033067
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Atomic structures of medin and Aβ fibrils reveal polymorphic remodeling in mixed amyloid systems.

Nat Commun. 2026 Apr 28; Epub 2026 Apr 28
Authors: Pradhan B, Kumar ST, Wagner J, Gallardo R, Orlando G, De Vleeschouwer M, Zorzini V, Madine J, Louros N, Neher JJ, Rousseau F, Schymkowitz J
PubMed: 42045275
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Identification of Secondary Nucleation Inhibitors of Amyloid-β Aggregation by Cellular Selection of a SICLOPPS Library.

Chembiochem. 2026 Apr 28;27(8):e202500908.
Authors: Lee B, Flood B, Potter E, Wang T
PubMed: 42041135
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Retraction Note: A novel approach integrating topological deep learning from EEG Data in Alzheimer's disease.

Sci Rep. 2026 Apr 28;16(1)
Authors: Esteve M, Martinez-Gracia A, Rodríguez-Sala JJ, Brotons-Mas JR, Falcó A
PubMed: 42050120
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Diagnostic accuracy of digital clock drawing test for Alzheimer disease and mild cognitive impairment.

NPJ Digit Med. 2026 Apr 28; Epub 2026 Apr 28
Authors: Chang SH, Lin HL, Qian H, Liu ZT, Lu J, Zhong BL
PubMed: 42050061
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Associations of social isolation and loneliness with neurological disorders, psychiatric disorders, brain structures and behavioural phenotypes among UK Biobank participants.

Nat Commun. 2026 Apr 28; Epub 2026 Apr 28
Authors: Zhao YL, Zhang DD, Gao PY, Fu Y, Ge YJ, Chi HC, Guo ZX, Yu HH, Feng JF, Tan L, Cheng W, Zhang YR, Yu JT
PubMed: 42049746
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Are Cannabis and/or Cannabinoids a Potential Therapy for ALS?

Muscle Nerve. 2026 Apr 28; Epub 2026 Apr 28
Authors: Vrana KE
PubMed: 42049669
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[Clinical practice guideline for integrated PET/MRI in Parkinson's disease (2026 edition)].

Zhonghua Yi Xue Za Zhi. 2026 Apr 28;106(16):1541-1554.
Authors: Chinese Society of Medical Imaging Technology, Chinese Society of Radiology, Chinese Society of Nuclear Medicine, Beijing Society of Nuclear Medicine, Beijing Society of Radiology
PubMed: 42049519
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[Clinical practice guideline for integrated PET/MRI in Alzheimer's disease (2026 edition)].

Zhonghua Yi Xue Za Zhi. 2026 Apr 28;106(16):1527-1540.
Authors: Chinese Society of Medical Imaging Technology, Chinese Society of Radiology, Chinese Society of Nuclear Medicine, Beijing Society of Nuclear Medicine, Beijing Society of Radiology
PubMed: 42049518
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Predicting Peptide Aggregation with Protein Language Model Embeddings.

J Chem Inf Model. 2026 Apr 28; Epub 2026 Apr 28
Authors: Eschbach E, Deibler K, Korani D, Swanson S
PubMed: 42049499
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α,β-Dehydroamino-Acid-Containing Peptides Resist Proteolysis and Inhibit Aggregation of a Tau-Derived Model Peptide.

J Org Chem. 2026 Apr 28; Epub 2026 Apr 28
Authors: Garcia SG, Almardini AA, Pereira AJ, Xing H, Knox LJ, Jimenez JV, Webster-Ford JC, Moyá DA, Payne JC, Dawes CK, Conda-Sheridan M, Castle SL
PubMed: 42048649
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Disrupted emotion-memory interactions in behavioral variant frontotemporal dementia.

Neurol Sci. 2026 Apr 28;47(5)
Authors: El Haj M, Chapelet G, Hallit S, Boutoleau-Bretonnière C
PubMed: 42047896
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Association Between Blood-Brain Barrier Disruption and Gut Microbiota Dysbiosis in Parkinson's Disease.

Cell Mol Neurobiol. 2026 Apr 28; Epub 2026 Apr 28
Authors: Yao W, Liu L, Wang J, Chen S, Zhang C, Liao R, Wang Y, Ou K, Jiang L, Yu Y, Dong W
PubMed: 42047847
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Parkinson's disease and the concept of resilience, cognitive, and motor reserve.

J Parkinsons Dis. 2026 Apr 28;:1877718X261444486. Epub 2026 Apr 28
Authors: Hoenig MC
PubMed: 42047602
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Associations of circulating resistin with Alzheimer's disease biomarkers and cognitive function in the preclinical stage of Alzheimer's disease.

J Alzheimers Dis. 2026 Apr 28;:13872877261442230. Epub 2026 Apr 28
Authors: Eruysal E, Ravdin L, Iadecola C, Ishii M
PubMed: 42047539
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Charge-Based Discrimination of Amyloids Using an Amyloid-Targeting Chemiluminescent Probe.

Chembiochem. 2026 Apr 28;27(8):e202600008.
Authors: Chung J, Jessup RE, Yang J
PubMed: 42047469
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Integrating Acridinium Ester with a Soluble Macromolecular Amplification Carrier for Ultrasensitive Detection of Aβ1-42 in Plasma.

Anal Chem. 2026 Apr 28; Epub 2026 Apr 28
Authors: Guo C, Liu M, An Z, Li S, Cui M, Nie J, Sun Y, Bai Z
PubMed: 42047375
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Innovative therapies under clinical development for ALS treatment: Small molecules.

Expert Opin Investig Drugs. 2026 Apr 28; Epub 2026 Apr 28
Authors: Martinez-Gonzalez L, Sanchez-Santos C, Huang CS, Gil C, Martinez A
PubMed: 42046889
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Medial temporal lobe Tau-Neurodegeneration mismatch from structural imaging and plasma biomarkers.

Brain. 2026 Apr 28; Epub 2026 Apr 28
Authors: Lyu X, Mundada NS, Brown CA, Sadeghpour N, McGrew E, Xie L, Li Y, Wuestefeld A, Duong MT, Cook P, Gee J, Nasrallah IM, Chen-Plotkin AS, Shaw LM, Mechanic-Hamilton D, Wisse LE, Yushkevich PA, Das SR, Wolk DA
PubMed: 42046390
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A digital twin methodology using retrospective patient data for sample size reduction in Alzheimer's disease clinical trials.

Alzheimers Res Ther. 2026 Apr 28; Epub 2026 Apr 28
Authors: Andrews D, Golchi S, Collins DL, Alzheimer’s Disease Neuroimaging Initiative
PubMed: 42046101
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From necroptosis to neuroinflammation: Unraveling mechanisms and therapeutic targets in age-related cognitive decline.

Biomed Pharmacother. 2026 Apr 28;199:119326. Epub 2026 Apr 28
Authors: Biscetti L, Gambuzza ME, Princiotto M, Sabbatinelli J, Olivieri F, Fiorillo M, Chinigò C, Muglia L, Cozza A, Beccacece A, Gembillo G, Bruschetta G, Villalta Savedra E, Lattanzio F, Corsonello A, Soraci L
PubMed: 42054746
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Rational design of η6-arene Ru(II) complexes for amyloid-β targeting: influence of coordination lability and aromaticity.

Dalton Trans. 2026 Apr 28; Epub 2026 Apr 28
Authors: Florio D, De Simone C, Annunziata A, Ruffo F, Marasco D, La Manna S
PubMed: 42052711
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A microglia membrane biomimetic platinum-based MOF-loaded quercetin nanodrug delivery system for the treatment of Alzheimer's disease.

J Mater Chem B. 2026 Apr 28; Epub 2026 Apr 28
Authors: Zhao R, Guo M, Yang F, Yan Y, Tian D, Deng L, Wang Q, Xie M
PubMed: 42052655
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Women's reproductive life patterns, intrinsic capacity, and the risk of all-cause and cause-specific dementia: a prospective cohort study.

Alzheimers Res Ther. 2026 Apr 28; Epub 2026 Apr 28
Authors: Zhang Y, Tan Q, Wu S, Xu X
PubMed: 42050742
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Impact of appendicular skeletal muscle mass on Alzheimer's disease in relation to age and comorbidities: an 8-year longitudinal follow-up study of a nationwide cohort.

Alzheimers Res Ther. 2026 Apr 28; Epub 2026 Apr 28
Authors: Chung SJ, Kang M, Park YJ, Oh K, Koh SB, Kang SH
PubMed: 42050739
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Shared genetic architecture between Alzheimer's disease and psychiatric disorders revealed by multi-trait genome-wide analyses.

BMC Med Genomics. 2026 Apr 28; Epub 2026 Apr 28
Authors: Zhang H, Xie L, Meng F, Cui J, Ma B, Wang Y, Zhang K, Miao X
PubMed: 42050540
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The Davos Alzheimer's Collaborative Healthcare System Preparedness US Early Detection of Cognitive Impairment Program in primary care: Methodology.

BMC Prim Care. 2026 Apr 28; Epub 2026 Apr 28
Authors: Hornbecker M, Suchsland MZ, MacLeod T, Koppenhofer MJ, Selzler KJ, Ferrell P, Deckert A
PubMed: 42050423
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Lipoprotein lipase facilitates Aβ transport across the blood-brain barrier via LRP1: Validation of the obesity paradox in Alzheimer's disease.

J Adv Res. 2026 Apr 28; Epub 2026 Apr 28
Authors: Meng N, Li C, Bai F, Zhang J, Li X, Zhang J, Zhang C, Fu J, Fu J, An L
PubMed: 42061814
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UNEXPECTED MECHANISMS OF REPURPOSED DRUGS IN THE PATHOGENIC PATHWAYS OF NEURODEGENERATIVE DISEASES. DISCOVERING NEW NEUROPROTECTIVE THERAPIES IN CELLULAR MODELS.

Neuropharmacology. 2026 Apr 28;:110994. Epub 2026 Apr 28
Authors: Arasmou-Idrovo MS, Marín-Rodríguez B, Gironda-Martínez A, García AG, León R, Pascual-Guerra J, Torres-Rico M
PubMed: 42061810
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Apolipoprotein E4 and Synaptic Dysfunction in Alzheimer's Disease: Mechanisms and Therapeutic Implications.

Ageing Res Rev. 2026 Apr 28;:103153. Epub 2026 Apr 28
Authors: Yao Z, Godje IS, Jiao B, Shen L, Luo SL
PubMed: 42061654
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Quantitative imaging of iron dysregulation in multiple system atrophy.

Neuroimage. 2026 Apr 28;334:121965. Epub 2026 Apr 28
Authors: Trujillo P, Hett K, Cooper A, Brown AE, Donahue MJ, McKnight CD, Bradbury M, Wong C, Stamler D, Claassen DO
PubMed: 42061593
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Energy metabolic failure drives the selective degeneration of dopaminergic neurons in Parkinson's disease.

Prog Neuropsychopharmacol Biol Psychiatry. 2026 Apr 28;:111722. Epub 2026 Apr 28
Authors: Zhou Z
PubMed: 42061580
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Impaired sleep microarchitecture is associated with locus coeruleus degeneration in Parkinson's disease.

Parkinsonism Relat Disord. 2026 Apr 28;147:108339. Epub 2026 Apr 28
Authors: Doppler CE, Sembowski N, Plottka D, Hommelsen M, Röttgen S, Schwabedal JT, Schreiner SJ, Fink GR, Borghammer P, Bialonski S, Sommerauer M
PubMed: 42061026
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Correction to: Dementia risk across distinct metabolic profiles in the UK Biobank.

Geroscience. 2026 Apr 27; Epub 2026 Apr 27
Authors: Lumsden AL, Mulugeta A, Hyppönen E
PubMed: 42036541
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LRRK2 and GBA1 in Lewy body diseases: neuropathological subtypes at opposite ends of a spectrum?

Mol Neurodegener. 2026 Apr 27; Epub 2026 Apr 27
Authors: Jha V, Kalia LV
PubMed: 42045964
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An interpretable deep learning diagnostic framework for early Alzheimer's disease based on EEG microstate spectra and multi-branch CNN.

J Neuroeng Rehabil. 2026 Apr 27; Epub 2026 Apr 27
Authors: Li Z, Li X, Qu Z, Su R, Yin B, Yin L
PubMed: 42045954
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Peripheral blood biomarkers RCAN1, Clusterin, RAGE, and malondialdehyde for early diagnosis and progression of Alzheimer's disease.

BMC Med. 2026 Apr 27; Epub 2026 Apr 27
Authors: Román-Domínguez A, Mas-Bargues C, Pérez V, Medina M, Ávila J, Borrás C, Viña J
PubMed: 42045900
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Modulation of biomolecular condensation of alpha-synuclein variants by eprodisate.

Commun Chem. 2026 Apr 27; Epub 2026 Apr 27
Authors: Biswas S, Mavlankar NA, Panuganti V, Pal A, Roy I
PubMed: 42045548
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Alzheimer's disease-like brain pattern biomarker: capturing risks and predicting disease onset.

Mol Psychiatry. 2026 Apr 27; Epub 2026 Apr 27
Authors: Kochunov P, Gao S, Salminen LE, Jahanshad N, Nir TM, Thompson PM, Du X, Adhikari BM, Kochunov A, Cassidy R, Ma Y, Chiappelli J, Ament S, Pan Y, Chen S, Shuldiner AR, Mitchell BD, Soares LJ, Hong LE
PubMed: 42045435
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Estren prevents beta-amyloid-induced basal forebrain cholinergic loss and long-term spatial memory deficits in aged female mice.

Sci Rep. 2026 Apr 27; Epub 2026 Apr 27
Authors: McLoughlin J, Sayfullaeva J, Kiliç E, Carmody C, Grochowska N, Potapov K, Potapov D, Clarkson A, Peppercorn K, Tate W, Kwakowsky A
PubMed: 42045407
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Effects of exercise modalities on cognitive and muscle function in older adults with cognitive impairment: a systematic review and meta-analysis.

Sci Rep. 2026 Apr 27; Epub 2026 Apr 27
Authors: Choe YH, Cho EJ, Choi Y, Park DH, Kang JH, Kwak HB
PubMed: 42045298
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The PM20D1-OLE pathway induces microglia rewiring to ameliorate Alzheimer disease.

Cell Death Dis. 2026 Apr 27; Epub 2026 Apr 27
Authors: Pozzi-Ruiz V, Giner de Gracia A, Glauser L, Romani M, Gunter-Rahman F, González-Ramón A, Haj-Yahya M, Kolla R, Burns AM, Lashuel HA, Auwerx J, Gräff J, Sanchez-Mut JV
PubMed: 42045164
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Correction to "Discovery of Potent, Selective, CNS-Penetrant Macrocyclic LRRK2 Inhibitors for the Treatment of Parkinson's Disease".

J Med Chem. 2026 Apr 27; Epub 2026 Apr 27
Authors: Yu EC, Zhou H, Yan X, Logan KM, Li D, Gulati A, Poremba KE, Ardolino MJ, Su J, Xiao D, Palte RL, McMinn SE, Nogle LM, Adpressa DA, Burgess SA, Xiong T, Otte KM, Chobanian HR, Bass A, Lee S, Pearson K, Messina E, Parisi M, Barnum J, Sobol Z, Ciaccio PJ, DiMauro EF, Fell MJ, Fuller PH
PubMed: 42045162
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Cerebrospinal Fluid Amyloid-β Biomarkers Predict Future Hemorrhage in Patients with Cerebral Amyloid Angiopathy.

Ann Neurol. 2026 Apr 27; Epub 2026 Apr 27
Authors: Arndt P, Pfister M, Perosa V, Mattern H, Tas M, Holzheimer L, Engel J, Dörner M, Al-Dubai M, Garz C, Khadhraoui E, Müller SJ, Müller P, Meuth SG, Neumann K, Schreiber S
PubMed: 42045103
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Stimuli-Chromic Oxazolidine Derivatives as Highly Efficient Molecular Probes for Monitoring Fibrillation Kinetics and Intracellular Detection of Amyloid Fibrils.

Biochemistry. 2026 Apr 27; Epub 2026 Apr 27
Authors: Tondkar F, Rezaeifar F, Ghorbani M, Abdollahi A, Meratan AA
PubMed: 42044386
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Chronic traumatic encephalopathy neuropathologic change is associated with highest stage limbic-predominant age-related TDP-43 encephalopathy.

J Neuropathol Exp Neurol. 2026 Apr 27; Epub 2026 Apr 27
Authors: Song H, Ameen-Ali KE, Kennedy-Dietrich C, Dolle JP, Lee EB, Smith DH, Stewart W, CONNECT-TBI Investigators
PubMed: 42044052
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The central role of mitochondrial dysfunction in neurodegeneration: implications for therapy.

Mol Cell Biochem. 2026 Apr 27; Epub 2026 Apr 27
Authors: Raafat MA, Al-Hasnaawei S, Mousa HM, Hanumanthayya M, Sahoo S, Prathiba S, Singh G, Sinha A
PubMed: 42043769
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Chitosan-curcumin nanoparticles: a potential nano-therapeutic for cognitive restoration in a streptozotocin-induced rat model of Alzheimer's disease.

Inflammopharmacology. 2026 Apr 27; Epub 2026 Apr 27
Authors: Khozani MS, Palizvan M, Mosayebi G, Ganji A, Ghazavi A
PubMed: 42043712
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Twenty-four-hour blood pressure and CSF biomarkers of Alzheimer's disease and related dementias in a community cohort.

Geroscience. 2026 Apr 27; Epub 2026 Apr 27
Authors: Gibson M, O'Brien WT, Rowsthorn E, Franks KH, Cribb L, Cavuoto M, Campbell-Brown B, Harding I, Law M, Chong TT, McDonald SJ, O'Brien TJ, Vivash L, Yiallourou S, Pase MP
PubMed: 42043710
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Role of Folate Metabolism in Neurodegenerative Diseases: Insight from Experimental and Clinical Studies.

Curr Nutr Rep. 2026 Apr 27;15(1)
Authors: Umar M, Franjieh K, White AL, Ward-Dones E, Ismael S, Roskey RC, Courseault J, Bix GJ
PubMed: 42043709
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Signaling Pathways Triggering Therapeutical Potential of Marine-Derived Polysaccharides in Alzheimer's Disease: A Recent Review.

Mol Neurobiol. 2026 Apr 27;63(1)
Authors: Kumar D, Kondaveeti SB, Agrawal M, Kumar A, Awasthi A, Mahmood S, Singh TG, Kumar M
PubMed: 42043700
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FTDP-17T Mutations Promote Formation of Phosphorylated FTDP-17T TAU Oligomers That Cause Degeneration of Dopaminergic and Hippocampal Neurons via Activating ER Stress and Mitochondrial Pro-apoptotic Cascades.

Neurochem Res. 2026 Apr 27;51(3)
Authors: Wang HL, Weng YH, Chiu CC, Chen WS, Liu SY, Yeh TH
PubMed: 42043652
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Correction: Cutaneous α-Synuclein Pathology as a Differential Marker: A Histological and Statistical Comparison across Neurodegenerative Disease Groups.

J Mol Neurosci. 2026 Apr 27;76(2)
Authors: Šebelová D, Menšíková K, Kaiserová M, Satke L, Grambalová Z, Čížková K, Tauber Z, Klíčová K, Hraboš D, Cook SE, Zapletalová J, Kaňovský P
PubMed: 42043620
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Targeting the BDNF/TrkB/CREB pathway: emerging strategies for neuroprotection in Parkinson's disease.

Mol Biol Rep. 2026 Apr 27;53(1)
Authors: Ahire C, Kaur G
PubMed: 42043595
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Plasma biomarkers of neurodegeneration and intraindividual cognitive variability: Comparing variability across test at one time point and using repeated ecological momentary assessment.

Neuropsychology. 2026 Apr 27; Epub 2026 Apr 27
Authors: Fonseca LM, Weeks DL, Cleveland M, Hawks ZW, Jung L, Kudva YC, Rizvi S, Bulger J, Grinspoon E, Janess K, Sliwinski M, Pratley RE, Rickels MR, Weinstock RS, Chhatwal JP, Kivisäkk PW, Beeri MS, Germine LT, Chaytor NS
PubMed: 42043433
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Barriers and enablers to cognitive assessment in Parkinson's disease: A qualitative contextual inquiry.

J Parkinsons Dis. 2026 Apr 27;:1877718X261440707. Epub 2026 Apr 27
Authors: Brooks D, Shrubsole K, Sriram D, Yang J, Mitchell LK, Worthy P, Lobo E, Pourzinal D, Dissanayaka NN
PubMed: 42041287
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Probing Allosteric Kinase Modulators as Next Game-Changers in Fighting Neurodegeneration.

J Med Chem. 2026 Apr 27; Epub 2026 Apr 27
Authors: Roggiolani E, Rosini M, Minarini A, Basagni F
PubMed: 42041106
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EXPRESS: Association Between PTEN-Induced Kinase 1 (PINK1) rs3738136 Polymorphism and Parkinson's Disease: A Meta-Analytic Study.

J Investig Med. 2026 Apr 27;:10815589261448841. Epub 2026 Apr 27
Authors: Shibi Anilkumar A, Thomas SM, Veerabathiran R
PubMed: 42037593
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Protective Effects of a Propolis-Petasites japonicus Mixture on Scopolamine-Induced Memory Impairment in Mice.

J Microbiol Biotechnol. 2026 Apr 27;36:e2602019.
Authors: Kim MY, Shin JY, Lim JH, Park JH, Hur YK, Yun SI, Cho BO, Jang SI
PubMed: 42049692
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Retraction notice to "Recent advancements of nanoparticles application in cancer and neurodegenerative disorders: At a glance" [Biomedicine & Pharmacotherapy 153 (2022) 113305].

Biomed Pharmacother. 2026 Apr 27;:119424. Epub 2026 Apr 27
Authors: Rahman MM, Islam MR, Akash S, Harun-Or-Rashid M, Ray TK, Rahaman MS, Islam M, Anika F, Hosain MK, Aovi FI, Hemeg HA, Rauf A, Wilairatana P
PubMed: 42049627
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Lipid-lowering regimens in Alzheimer's disease dementia: small effects with potential long-term benefit.

J Prev Alzheimers Dis. 2026 Apr 27;13(6):100576. Epub 2026 Apr 27
Authors: Hartmann T
PubMed: 42048844
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The Unusual Suspects: Macrophages in Parkinson's Disease?

Mov Disord. 2026 Apr 27; Epub 2026 Apr 27
Authors: Bhardwaj S, Stezin A
PubMed: 42046394
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N-terminally acetylated Met11-Tau: a new pathological truncated Tau species with functional relevance in Alzheimer's disease.

Transl Neurodegener. 2026 Apr 27;15(1)
Authors: Guedjdal S, Leghay C, Derisbourg M, Eddarkaoui S, Lecerf S, Vermon F, Caillierez R, Begard S, Regost C, Laloux C, da Costa PJ, Carvalho K, Chiappetta G, Verdier Y, Buée-Scherrer V, Deramecourt V, Schraen S, Blum D, Martin F, Buée L, Hamdane M
PubMed: 42046086
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Amyloid-beta statuses prediction with free water MR imaging features in Alzheimer's disease using machine learning models.

BMC Med Imaging. 2026 Apr 27;26(1)
Authors: Zhou R, Sun X, Chen S, Zhao S, Zhao C, Qu J, Zeng W, Li C, Zhang X, Li Z, Wang Y, Zhang T, Xu X, Jia J, Liang Y
PubMed: 42046023
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Essence: A benchmarking-validated transformer framework for early diagnosis of Parkinson's disease using cerebrospinal fluid protein biomarkers.

Int J Biol Macromol. 2026 Apr 27;:152244. Epub 2026 Apr 27
Authors: Zhou Z, Xie X, Hao Y, Han K, Wang T, Hong F, Wei Y, Xie S, Luo X, Li X, Liu L, Dao F, Lin H, Lai H, Lyu H
PubMed: 42055361
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A coherent structural picture of the interaction of Tau with tubulin provides a link to its aggregation.

J Biol Chem. 2026 Apr 27;:113086. Epub 2026 Apr 27
Authors: Gigant B, Khodja LA, Campanacci V, Lippens G
PubMed: 42055333
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Bridging the gaps in Alzheimer's disease biomarker research: From multi-omics integration to point-of-care diagnostics, a comprehensive review.

Clin Chim Acta. 2026 Apr 27;589:121046. Epub 2026 Apr 27
Authors: Khasanov S, Tolibov M, Daminova N
PubMed: 42055309
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Selective vulnerability of monoaminergic neurons and network spread of alpha-synuclein jointly explain pathology progression in Parkinson's disease models.

Neurobiol Dis. 2026 Apr 27;:107403. Epub 2026 Apr 27
Authors: Teshome S, Torok J, Mezias C, Gupta A, Raj A
PubMed: 42055257
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Cognitive trajectories in early Parkinson's disease: A multimodal MRI study of brain structure and cognitive decline.

Neurobiol Dis. 2026 Apr 27;:107407. Epub 2026 Apr 27
Authors: Wen C, Xing Y, Zhou H, Li J, Feng Y, Xu Y, Shi H, Hu X, Zheng J, Liu W
PubMed: 42055256
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Compensatory and impaired trust updating in mild cognitive impairment: Evidence from computational modeling and fMRI.

Neuroimage. 2026 Apr 27;:121956. Epub 2026 Apr 27
Authors: Chen Y, He H, Ding Y, Tao W, Guan Q, Krueger F
PubMed: 42055236
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Longitudinal Surface-Based Morphometry Changes in the Hippocampus in Dementia.

Neuropsychologia. 2026 Apr 27;:109470. Epub 2026 Apr 27
Authors: Aziz S, Penheiro R, Morrison C, Zhukovsky P, Anderson JA, Alzheimer's Disease Neuroimaging Initiative (ADNI)
PubMed: 42055188
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Icariin promotes lysosomal degradation of amyloid-β precursor protein via enhanced endosome-lysosome trafficking to reduce amyloid-β accumulation and improve cognitive function in Alzheimer's disease models.

Brain Res Bull. 2026 Apr 27;240:111906. Epub 2026 Apr 27
Authors: Lin C, Xu Z, Yan J, Liu B, Li F
PubMed: 42055146
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The role of ultrasound in addressing neurodegenerative diseases: A review of mechanisms, applications, and challenges.

Neuroscience. 2026 Apr 27;606:126-137. Epub 2026 Apr 27
Authors: Zhu Y, Zhang H, Zhang Z, Song G, Fu J, Wang H
PubMed: 42055109
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Tiny Titans, big promise: Nanotechnology and microRNA in the fight against Alzheimer's disease.

Ageing Res Rev. 2026 Apr 27;119:103149. Epub 2026 Apr 27
Authors: Nakum B, Vejpara D, Faldu K, Soni R, Shah J
PubMed: 42055093
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Serious side effects of Alzheimer's immunotherapy demand scrutiny.

Ageing Res Rev. 2026 Apr 27;119:103151. Epub 2026 Apr 27
Authors: Høilund-Carlsen PF, Alavi A, Andalib S, Castellani RJ, Costa T, de Girolamo G, Espay AJ, Neve RL, Perry G, Revheim ME, Robakis NK, Sensi SL, Vissel B, Barrio JR
PubMed: 42055092
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Poly-GR promotes ferroptosis-associated vulnerability in C9orf72-ALS.

Cell Biosci. 2026 Apr 26; Epub 2026 Apr 26
Authors: Lin CY, Hsieh WC, Wang SM
PubMed: 42036719
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Seeing Invisible Oligomers: Rethinking α-Synuclein Pathology Through Proximity Ligation Assay.

Mov Disord. 2026 Apr 26; Epub 2026 Apr 26
Authors: Sekiya H, Jensen NM, Dickson DW, Jensen PH
PubMed: 42036389
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Data-driven thresholds for standardized classification of severe Alzheimer's disease neuropathology using digital neuropathology.

Brain Pathol. 2026 Apr 26;:e70102. Epub 2026 Apr 26
Authors: Shahidehpour RK, Neltner AM, Klusty MA, Corbett C, Gonzalez AD, Gutman DA, Fardo DW, Bachstetter AD, Bumgardner C, Flanagan ME, Nelson PT
PubMed: 42035704
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Social dysfunction and default mode network functional integrity in neuropsychiatric disorders: A cross-disorder replication and generalization study.

Eur Neuropsychopharmacol. 2026 Apr 26;110:112847. Epub 2026 Apr 26
Authors: Braak S, Mennes M, Su T, Pijnenburg Y, Bakker G, Arango C, van der Wee N, Bauduin S, Ortiz-Tallo Moya A, Lopez-Morinigo JD, Dawson GR, Abrahams AB, Beckenstrom AC, Beckmann CF, Marston HM, Penninx BW, Kas MJ
PubMed: 42044556
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Insights Gained From the PPMI Brain Donation Program.

Ann Neurol. 2026 Apr 26; Epub 2026 Apr 26
Authors: Foroud T, Heathers LE, Bukhari S, Poston KL, Antonopoulos G, Mantravadi K, Rumbaugh M, Mac Donald CL, Latimer CS, Tropea TF, Marek K, Keene CD, Montine TJ, Parkinson's Progression Markers Initiative
PubMed: 42036930
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Guiding Approaches to Studying Alzheimer's Disease: A Scoping Review of Community Engagement, Health Communication, and Implementation Science Research.

Gerontologist. 2026 Apr 26; Epub 2026 Apr 26
Authors: Yelton B, Workman L, Schaurer L, Riccardi N, McCollum Q, Belza B, Ory MG, Thorpe RJ, Wheeler SB, Trinh-Shevrin C, Kreps GL, Langa KM, Friedman DB
PubMed: 42036812
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Plasma NfL, GFAP and pTau181 define distinct biological axes in amyotrophic lateral sclerosis.

Neurobiol Dis. 2026 Apr 26;224:107415. Epub 2026 Apr 26
Authors: Senerchia G, Iuzzolino VV, Spisto M, Panico F, Polito C, Aruta L, Fiorenza M, Sirica R, Terracciano D, Dubbioso R
PubMed: 42049146
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Humanized mice carrying a pathogenic GRN deletion as a pre-clinical platform for targeted gene therapies in frontotemporal dementia.

Neurobiol Dis. 2026 Apr 26;:107419. Epub 2026 Apr 26
Authors: Life BE, Kazemian P, Petkau TL, de Moura Gomes A, Thomson SB, Shen N, Myung J, Jayousi F, Lengyell TC, Lange PF, Simpson EM, Korthauer K, Leavitt BR
PubMed: 42049145
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Physiological and pathological functions of TAF15 in neurodegenerative diseases and cancers.

J Adv Res. 2026 Apr 26; Epub 2026 Apr 26
Authors: Liu C, Meng L, Zhang Z
PubMed: 42049092
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Does insomnia severity increase the risk of dementia? A 7-year longitudinal study.

Arch Gerontol Geriatr. 2026 Apr 26;148:106274. Epub 2026 Apr 26
Authors: Oo AT, Yamada T, Sato S, Takeda N, Nakamura M, Ueda T, Kitabatake Y, Maruo K, Arao T, Nemoto Y
PubMed: 42060953
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Association between amyloid-β deposition and cognitive function in cognitively normal adults: a multilevel meta-analysis.

Alzheimers Res Ther. 2026 Apr 25; Epub 2026 Apr 25
Authors: Huang Y, Gong Q, Zhong Z, Guo Q
PubMed: 42032771
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In silico design, chemistry and biological activity of thiazole-based azetidinone Schiff bases as potential anti-Alzheimer agents.

J Comput Aided Mol Des. 2026 Apr 25;40(1)
Authors: Johny ST, James JP, Cherangai ZF, Vasudevan R, Vidya VS, Dixit S, Parameswaran S
PubMed: 42032417
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Opportunities and challenges related to participant stratification and cohort enrichment in ALS clinical trials.

Amyotroph Lateral Scler Frontotemporal Degener. 2026 Apr 25;:1-10. Epub 2026 Apr 25
Authors: Yusuf S, Allen MD, Kang H, Phillips DE, Genge A
PubMed: 42033202
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Schedule-dependent neuroprotection by pioglitazone in a novel model of α-synucleinopathy in rats: Integrated behavioural and histological outcomes.

Br J Pharmacol. 2026 Apr 25; Epub 2026 Apr 25
Authors: Santiago-Balmaseda A, Villegas-Rojas MM, Pérez-Segura I, Espino-Cambrón M, Martinez-Fong D, Soto-Rojas LO
PubMed: 42033189
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Presenilin 1 is located in the mitochondrial inner inner membrane and regulates mitochondrial cristae junction protein arrangement and cristae formation in HEK293 cells.

Acta Biochim Biophys Sin (Shanghai). 2026 Apr 25; Epub 2026 Apr 25
Authors: You P, Zhu P, Yu H, Wang L, Su B
PubMed: 42033138
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In vivo tau in epilepsy reflects clinical severity and immune- and ageing-related proteomic changes.

Brain. 2026 Apr 25; Epub 2026 Apr 25
Authors: Hong SB, Shin YW, Moon J, Park KI, Jung KY, Cho K, Choi H, Chu K, Lee SK
PubMed: 42032827
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Genetic drivers of progression in Alzheimer's disease are distinct from disease risk.

Alzheimers Res Ther. 2026 Apr 25; Epub 2026 Apr 25
Authors: Cohen CE, Fernandez S, Yaman U, Ehyaei AR, Kodosaki E, Askarova A, Porter T, O'Brien E, Australian Imaging Biomarkers and Lifestyle Study, Alzheimer’s Disease Neuroimaging Initiative, Maruff P, Nott A, Hardy JA, Laws SM, A Salih D, Shoai M
PubMed: 42035106
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Lactate metabolism links reactive microglia, amyloid pathology, and Aβ dynamics.

J Neuroinflammation. 2026 Apr 25; Epub 2026 Apr 25
Authors: Ashley CC, Constantino NJ, Pettit-Mee RJ, Snipes JA, Saito K, Irmen RE, Zhang R, Neary EM, Lanning MJ, Karch CM, Johnson LA, Morganti JM, Macauley SL
PubMed: 42035056
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Targeting central immune signaling enhances the effects of methylphenidate in alleviating apathy-like behavior in 5xFAD mice.

Sci Rep. 2026 Apr 25; Epub 2026 Apr 25
Authors: Monteiro R, Dunn JT, Rodriguez G, Fisher DW, Dong H
PubMed: 42034805
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Passive digital health technologies for Alzheimer's disease screening and diagnosis: a systematic review.

NPJ Digit Med. 2026 Apr 25; Epub 2026 Apr 25
Authors: Matias I, Prociów P, Daza EJ, Kliegel M, Wac K
PubMed: 42034769
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Adaptive neighborhood aggregation graph neural network for early diagnosis of Alzheimer's disease.

Sci Rep. 2026 Apr 25; Epub 2026 Apr 25
Authors: Sheng J, Zhong H, Zhang Q, Zhang R, Gong Z, Lin J, Chen Z
PubMed: 42034728
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von Willebrand Factor fibers formed at pathological high shear provide a scaffold for α-synuclein binding and aggregation.

Sci Rep. 2026 Apr 25; Epub 2026 Apr 25
Authors: Rossi JM, Diamond SL
PubMed: 42034708
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Plasma proteomics for Parkinson's disease classification: cross-cohort benchmarking of proteomic, transcriptomic, and multimodal models.

NPJ Parkinsons Dis. 2026 Apr 25; Epub 2026 Apr 25
Authors: Minster N, Jafri S
PubMed: 42034648
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Mapping Neurodegenerative Changes in Clinically Uncertain Parkinsonian Syndrome Patients Using Fast MR Spin TomogrAphy in Time-Domain (MR-STAT) Relaxometry at 3T.

J Magn Reson Imaging. 2026 Apr 25; Epub 2026 Apr 25
Authors: Schilder MB, Wallert ED, Mandija S, van der Heide O, Liu H, Fuderer M, Versteeg E, Booij J, de Bie RM, Beudel M, Berendse HW, van Mierlo T, Blankevoort J, van den Berg CA, van de Giessen E, Sbrizzi A
PubMed: 42033789
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Reduced expression of SOCS1-5 and STAT5a genes in Parkinson's disease patients: evidence for dysregulated immune signaling.

Mol Biol Rep. 2026 Apr 25;53(1)
Authors: Salmani M, Rastegari-Pouyani M, Afshar S, Talebi-Ghane E, Eftekharian MM
PubMed: 42033629
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Unveiling the Gut-Brain Axis: Fusobacteriaceae Promotes Parkinson's Disease Development via CA9 Suppression-Induced Ferroptosis.

J Mol Neurosci. 2026 Apr 25;76(2)
Authors: Zihan R, Pengfei L, Jingsi C
PubMed: 42033567
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Brain PET in the era of anti-amyloid-β antibody therapy for Alzheimer disease.

Jpn J Radiol. 2026 Apr 25; Epub 2026 Apr 25
Authors: Ishii K
PubMed: 42033565
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Age-related macular degeneration and dementia: Association through pathogenesis or visual impairment?

J Alzheimers Dis. 2026 Apr 25;:13872877261438849. Epub 2026 Apr 25
Authors: Gu X, Terebuh P, Xu R, Kaelber DC, Davis PB
PubMed: 42033410
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Plasma phosphorylated tau 181, vascular risk factors, and cognition in elderly Hispanics.

J Alzheimers Dis. 2026 Apr 25;:13872877261443653. Epub 2026 Apr 25
Authors: Bahl A, Honig LS, Kang MS, Sanchez D, Reyes-Dumeyer D, Manly JJ, Lantigua RA, Brickman AM, Vardarajan BN, Mayeux R, Gu Y
PubMed: 42033409
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Dietary intervention and cognition across Alzheimer's disease biomarker levels: The MIND clinical trial.

J Alzheimers Dis. 2026 Apr 25;:13872877261442856. Epub 2026 Apr 25
Authors: Dhana K, Aggarwal NT, Arfanakis K, Sacks FM, Barnes LL
PubMed: 42033408
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Dementia screening with the Rivermead Behavioural Memory Test: A machine learning analysis.

J Alzheimers Dis. 2026 Apr 25;:13872877261443699. Epub 2026 Apr 25
Authors: Fujiwara Y, Toyoda K, Maruyama S, Kitano M, Toda H, Kanazawa T
PubMed: 42033406
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Lysosome-Acidifying Nanoparticles Rescue A30P α-Synuclein Induced Neuronal Death in Cellular and Drosophila Models of Parkinson's Disease.

Adv Healthc Mater. 2026 Apr 25;:e02906. Epub 2026 Apr 25
Authors: Lo CH, Ren M, Loi GW, Saipuljumri EN, Indajang J, Lim KL, Zeng J
PubMed: 42033266
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Large-Screen Group Digital Reminiscence Therapy Reduces BPSD in Dementia: Findings from a Crossover Comparative Study.

Clin Gerontol. 2026 Apr 25;:1-12. Epub 2026 Apr 25
Authors: Asano T, Izumi K, Ishikawa T
PubMed: 42033242
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Mitochondrial-nuclear crosstalk: A central axis in Alzheimer's disease.

Ageing Res Rev. 2026 Apr 25;119:103150. Epub 2026 Apr 25
Authors: Samantaray K, Sinha A, Tomar D, Jadiya P
PubMed: 42044748
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Reductions in regional cerebral blood flow and dopamine transporter uptake in a patient with Gerstmann-Sträussler-Scheinker disease harboring the prion protein gene P105L mutation.

J Neurol Sci. 2026 Apr 25;486:125941. Epub 2026 Apr 25
Authors: Ikeda M, Kuwabara T, Amari M, Ishiguro T, Inohana Y, Kasuga K, Hara N, Miyashita A, Higuchi T, Tsushima Y, Ikeuchi T, Okamoto K, Takatama M
PubMed: 42061151
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Olfactory radiomics signatures link pTau217 to cognitive impairment in probable Alzheimer's disease: a multi-cohort machine learning study.

Alzheimers Res Ther. 2026 Apr 24; Epub 2026 Apr 24
Authors: Chen B, Gao P, Liu H, Xu D, Wang Q, Yang M, Tan H, Xiao Z, Tian S, Wang Z, Zheng Y, Zheng X, Liang S, Liu Q, Li J, Zhong X, Ning Y
PubMed: 42032766
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Plasma proteomic signatures of preclinical Alzheimer's disease in clinically unimpaired older adults.

Mol Neurodegener. 2026 Apr 24; Epub 2026 Apr 24
Authors: Trelle AN, Cody KA, Nguyen TT, Winer JR, Weiss S, Sai I, Ward T, Cheng G, Channappa D, Mendiola J, Al-Rajhi A, Raghuraman K, Sha SJ, Wilson EN, Wyss-Coray T, Maecker HT, Wagner AD, Mormino EC
PubMed: 42032756
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Pathways to resilience: relationships between cognitive reserve, psychological debt, and Alzheimer's disease biomarkers.

Alzheimers Res Ther. 2026 Apr 24;18(1)
Authors: Boscheck H, Luft M, Mauer R, Senguel S, D'elia Y, Dechent P, Fliessbach K, Glanz W, Hetzer S, Janowitz D, Kilimann I, Kleineidam L, Kronmüller M, Lüsebrink F, Preis L, Rauchmann B, Rostamzadeh A, Schott BH, Sodenkamp S, Spruth E, Stoecklein S, Yakupov R, Ziegler G, Brosseron F, Buerger K, Hellmann-Regen J, Laske C, Perneczky R, Peters O, Priller J, Ramirez A, Schneider A, Spottke A, Teipel S, Wiltfang J, Jessen F, Düzel E, Röske S, Wagner M, Glöckner F, Marchant NL, Klimecki O, Wirth M, DELCODE study group
PubMed: 42032739
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Author Correction: Astrocytic Sox9 overexpression in Alzheimer's disease mouse models promotes Aβ plaque phagocytosis and preserves cognitive function.

Nat Neurosci. 2026 Apr 24; Epub 2026 Apr 24
Authors: Choi DJ, Murali S, Kwon W, Woo J, Song EC, Ko Y, Sardar D, Lozzi B, Cheng YT, Williamson MR, Huang TW, Sanchez K, Jankowsky J, Deneen B
PubMed: 42032434
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Application of a Three-Cell Blood-Brain Barrier Model to Assess Neurovascular Unit Cell Damage in Alzheimer's Disease.

Bull Exp Biol Med. 2026 Apr 24; Epub 2026 Apr 24
Authors: Rozanova NA, Averchuk AS, Kapkaeva MR, Zhdankina VI, Makarov VI, Skobeltsin AS, Romanishkin ID, Baranich TI, Salmina AB
PubMed: 42032403
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DeepDrugDiscovery identifies blood-brain barrier permeable autophagy enhancers for Alzheimer's disease.

Nat Biomed Eng. 2026 Apr 24; Epub 2026 Apr 24
Authors: Dong Y, Xiao X, Zhuang XX, Wu W, Wang ZY, Zhang S, Li JT, Zhang K, Fu WY, Chen JM, Xiong SH, Deng S, Li K, Ma C, Jin W, Jin X, Cai Q, Shen HM, Li M, Su H, Wan JB, Yu H, Ouyang D, Ye K, Fang EF, Tan CS, Yang G, Niu Z, Lu JH
PubMed: 42032039
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LASSO-HHO two-stage hybrid gene selection framework for accurate Alzheimer's disease diagnosis.

Sci Rep. 2026 Apr 24;16(1)
Authors: Asiry O, El-Gawady A, Eltoukhy MM, Mohamed MF
PubMed: 42031881
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Disruption of the LRRK2 substrate RAB12 facilitates neurotransmission and causes hyperactivity in mice.

NPJ Parkinsons Dis. 2026 Apr 24; Epub 2026 Apr 24
Authors: Li X, Chen Y, Wang H, Zhang X, Guiberson NG, Li X, Burré J, Peng J, Zhang H, Yue Z
PubMed: 42031745
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An Immuno-Infrared Sensor Detects Preclinical Alzheimer's and Parkinson's Disease by Protein Misfolding.

J Phys Chem B. 2026 Apr 24; Epub 2026 Apr 24
Authors: Gerwert G, Mann M, Langenhoff L, Woitzik N, Hubert D, Duman D, Höveler A, Budde S, Simon J, Beyer L, Schuler M, Weber S, Mollenhauer B, Kötting C, Güldenhaupt J, Gerwert K
PubMed: 42031363
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Modulation of Mitochondrial Dynamics by Loganic Acid Ameliorates Alzheimer's Disease Pathology: Evidence from In Vitro and In Vivo Studies.

ACS Chem Neurosci. 2026 Apr 24; Epub 2026 Apr 24
Authors: Panda SR, Soni U, Panja P, Rajdev B, Singh M, Kundu S, Ranade A, Pawar SD, Acharya R, Naidu VG
PubMed: 42030370
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Parental obesity exacerbates cognitive dysfunction and cardiac vulnerability in offspring of an Alzheimer disease model.

Am J Physiol Heart Circ Physiol. 2026 Apr 24; Epub 2026 Apr 24
Authors: do Carmo JM, Hall JE, Ladnier E, Dai X, Wang Z, Mouton AJ, Omoto AC, Jorge L, da Silva AA
PubMed: 42030244
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Toxic Alpha-Synuclein and the Opening of the Gate: Blood-Brain Barrier Damage and Stepwise Leukocyte Infiltration.

Cell Mol Neurobiol. 2026 Apr 24; Epub 2026 Apr 24
Authors: Wójcik P, Culmsee C, Adamczyk A
PubMed: 42029809
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TDP-43 Dysfunction Causes Hyper-Lactate State, Increased AARS1 Expression and Enhanced Protein Lactylation.

Neurotox Res. 2026 Apr 24;44(3)
Authors: Zhang T, Yan K, Liao Q, Liu R, Liu R, Zhou J, Liu Y, Bi F
PubMed: 42029805
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A perspective for alzheimer disease from gut microbiota-associated NMR-based fecal metabolomics: a study with 5XFAD mice.

Metab Brain Dis. 2026 Apr 24;41(1)
Authors: Tekin N, Şahin F, Şahin B, Kaya ZZ, Yılmaz A, Graham SF, Serteser M, Baykal AT
PubMed: 42029761
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Altered astrocyte-neuron crosstalk in progressive supranuclear palsy: integrated evidence from proteomics and magnetic resonance spectroscopy.

Acta Neuropathol. 2026 Apr 24;151(1)
Authors: Ono M, Kumagai Y, Hirata K, Maeda Y, Abe Y, Endo H, Shimizu H, Kakita A, Uchida Y, Takado Y
PubMed: 42029746
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The Development of the Novel Positron Emission Tomography Radiotracer for Selective HDAC8 Imaging.

ACS Chem Neurosci. 2026 Apr 24; Epub 2026 Apr 24
Authors: Huang Y, Wang Y, Wang Y, Cheng H, Yang H, Wang C, Xu Y
PubMed: 42029694
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Cause, consequence, or synergy: the role of T-cell infiltration across neurodegenerative diseases.

Brain. 2026 Apr 24; Epub 2026 Apr 24
Authors: Cullinane PW, Nelvagal H, Wong C, Curless T, Baranauskiene G, Jurkeviciene J, Farin Z, Pimparkar S, Bechtawi M, Chiraki N, de Pablo Fernandez E, Brandner S, Warner TT, Lim YM, Jaunmuktane Z
PubMed: 42028849
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Cross-sectional assessment of telephone- and computer-administered instruments in detection of cognitive impairment.

J Clin Exp Neuropsychol. 2026 Apr 24;:1-12. Epub 2026 Apr 24
Authors: Aaltonen A, Saari TT, Urjansson M, Palviainen T, Paajanen TI, FinnGen, Palotie A, Runz H, Kaprio J, Julkunen V, Vuoksimaa E
PubMed: 42027189
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Moiety-specific mechanism of ATP's hydrotropic action on α-synuclein.

Phys Chem Chem Phys. 2026 Apr 24; Epub 2026 Apr 24
Authors: Shuto Y, Mori T, Kohn B, Walinda E, Morimoto D, Scheler U, So M, Furukawa A, Yoshida N, Sugase K
PubMed: 42027070
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Synthesis and Evaluation of a PET Radiotracer [18F]LY3000328 Selectively Targeting the Cysteine Protease Cathepsin S.

ACS Chem Neurosci. 2026 Apr 24; Epub 2026 Apr 24
Authors: Yang H, Wang Y, Wang Y, Cheng H, Huang Y, Xu Y, Zhang C, Wang C
PubMed: 42032832
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Analysis of mitochondrial DNA heteroplasmy in sporadic ALS suggests technical limitations rather than disease association.

Neurobiol Dis. 2026 Apr 24;224:107412. Epub 2026 Apr 24
Authors: Codron P, Desquiret V, Prunier D, Amati-Bonneau P, Nguefackngoune V, Rapenne C, Legoff L, Cassereau J, Procaccio V
PubMed: 42035928
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Galectins as stress-integrating regulators of neuroimmune signaling and proteinopathy in the central nervous system.

Neurobiol Dis. 2026 Apr 24;224:107410. Epub 2026 Apr 24
Authors: Siew JJ, Chern Y
PubMed: 42035925
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Blood-based biomarkers of ferroptosis in Parkinson's disease.

Neurobiol Dis. 2026 Apr 24;:107414. Epub 2026 Apr 24
Authors: Huin V, Cailliau E, Poupelin C, Garcon G, Dutheil M, Simonin O, Beauval N, Labreuche J, Blum D, Moreau C, Hainque E, Marques A, Eusebio A, Benatru I, Brefel-Courbon C, Maltete D, Giordana C, Tir M, Thobois S, Brandel JP, Jarraya B, Hopes L, Rascol O, Corvol JC, Devos D, Rolland AS, PREDISTIM study group
PubMed: 42035924
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Challenging memory tests in early Alzheimer's disease: From research to clinical practice.

Neurosci Biobehav Rev. 2026 Apr 24;186:106701. Epub 2026 Apr 24
Authors: Horakova H, Fendrych Mazancova A, Vyhnalek M
PubMed: 42035900
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Vitamin E and melatonin synergistically attenuate sleep deprivation-induced Nrf2 dysregulation and hippocampal ferroptosis in Alzheimer's disease mouse models.

Exp Neurol. 2026 Apr 24;402:115781. Epub 2026 Apr 24
Authors: Gao Q, Sun J, Hei B, Zhou J, Wang B, Wang D, Hu S, Liu J, Wang D, Fan J
PubMed: 42035843
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Health-economic challenges for new Alzheimer's disease treatments.

J Prev Alzheimers Dis. 2026 Apr 24;13(6):100575. Epub 2026 Apr 24
Authors: Fu J, Sköldunger A, Bradshaw A, Broulíková HM, Brück CC, Chapel JM, Grimm S, Hansson A, Herring WL, Hlávka J, Hoang MT, Jönsson L, Landeiro F, Mar J, McKean A, Misik M, Neumann P, Rapp T, Ritchie C, Schiel A, Sun Y, Trépel D, Trueman D, van der Veere PJ, van Rosmalen L, Vonsy JL, Walker L, Wimo A, Winblad B, Xia X, Handels R
PubMed: 42034066
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Transcriptional profiles of immature neurons in aged human hippocampus track Alzheimer's pathology and cognitive resilience.

Cell Stem Cell. 2026 Apr 24; Epub 2026 Apr 24
Authors: Tosoni G, Ayyildiz D, Snoeck S, Moreno-Jiménez EP, Penning A, Santiago-Mujika E, Ruiz Ormaechea O, Lee H, Poovathingal S, Davie K, Bryois J, Macnair W, Anink J, De Vries LE, Farmand S, Nutma E, Swaab DF, Aronica E, Middeldorp J, Thuret S, Roybon L, Basak O, Fitzsimons CP, Lucassen PJ, Salta E
PubMed: 42034060
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Translating brain anatomy and disease from mouse to human in latent gene expression space.

EBioMedicine. 2026 Apr 24;127:106259. Epub 2026 Apr 24
Authors: Jaroszynski C, Amer M, Beauchamp A, Lerch JP, Sotiropoulos SN, Mars RB
PubMed: 42034047
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Multi-ancestry studies in multi-omics of Alzheimer's disease: Recent insights and future directions.

Curr Opin Neurobiol. 2026 Apr 24;99:103205. Epub 2026 Apr 24
Authors: Shir D, Seifar F, Ertekin-Taner N
PubMed: 42033978
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Complement C3aR deletion does not attenuate degeneration in a tauopathy model or alter acute inflammation-induced gene expression changes.

Cell Rep. 2026 Apr 24;45(5):117313. Epub 2026 Apr 24
Authors: Wang Y, Pandey S, Weber M, Choy MK, Wu T, Chernov-Rogan T, Adrian M, Tsai MC, Ngu H, Foreman O, Xie L, Hanson JE
PubMed: 42033726
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Safety and efficacy of the anti-α-synuclein monoclonal antibody amlenetug for the treatment of patients with multiple system atrophy (AMULET): a phase 2, randomised, double-blind, multicentre trial.

Lancet Neurol. 2026 Apr 24; Epub 2026 Apr 24
Authors: Kjærsgaard L, Wiedemann J, Singer W, Takeda A, Berger AK, Flensburg MF, Hansen L, Kallunki P, Kompus K, Nighah K, Schmidt SN, Jørgensen MN, Svanholm Fogh B, Zanigni S, Luthman J, AMULET Trial Group
PubMed: 42044642
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Comparative proteomic analysis of cerebrospinal fluid and brain tissue using Orbitrap Astral and timsTOF Pro 2 platforms with data-independent acquisition.

Diagnosis (Berl). 2026 Apr 24; Epub 2026 Apr 24
Authors: Chatanaka MK, Lorén MP, Wong CJ, Soosaipillai A, Boada M, Molina-Porcel L, Morató X, Prassas I, Diamandis EP
PubMed: 42044326
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The influence of beta-amyloid and tau proteins on cognitive changes in Parkinson's disease.

Parkinsonism Relat Disord. 2026 Apr 24;:108332. Epub 2026 Apr 24
Authors: Abraham B, Carl S, Ye L, Wegner F, Höllerhage M, Schulze Westhoff M, Konen F, Schneidereit IV, Skripuletz T, Klietz M
PubMed: 42062191
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Recent advances in the development of selective hMAO-B inhibitors for neurodegenerative diseases: An update from 2020 to present.

Eur J Med Chem. 2026 Apr 24;313:118893. Epub 2026 Apr 24
Authors: Salerno S, Fabbri G, Di Paolo ML, Piazzola F, Piccarducci R, Costa B, Castellano S, Dalla Via L, Taliani S, Da Settimo F
PubMed: 42060966
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LOESS-based normalization workflow for targeted HDL glycoproteomics in an Alzheimer's disease cohort.

RSC Adv. 2026 Apr 24;16(24):22252-22260. Epub 2026 Apr 28
Authors: Hong BV, Liu Y, Oloumi A, K Agus J, Bouchibti Y, Jin LW, Maezawa I, Harvey DJ, Lebrilla CB, Zivkovic AM
PubMed: 42058034
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Corrigendum to "Demethyleneberberine attenuates combined cognitive and metabolic dysfunctions in an insulin-resistance-induced Alzheimer's disease rat model: Synthesis, in-silico and in-vivo insights" [Experimental Neurology, 398 (2026) 115634].

Exp Neurol. 2026 Apr 23;:115774. Epub 2026 Apr 23
Authors: Kaur A, Singh S, Singh M, Silakari P, Mannan A, Vishwas S, Kumar P, Subramaniyan V, Singh TG
PubMed: 42031657
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Mild cognitive impairment: New directions in predictors, diagnosis and biomarkers.

Int Psychogeriatr. 2026 Apr 23;:100211. Epub 2026 Apr 23
Authors: Fischer CE
PubMed: 42031631
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Single-molecule detection methods to study alpha-synuclein aggregation in postmortem Parkinson's disease brains.

Cell Rep Methods. 2026 Apr 23;:101418. Epub 2026 Apr 23
Authors: Fertan E, Danial JS, Neame S, Lam JY, Cotton MW, Burke M, Xia Z, Wu Y, Powney B, Imaizumi Y, Quaegebeur A, Meisl G, Staddon J, Klenerman D
PubMed: 42030949
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Redox regulation of neuroinflammatory pathways contributes to damage in Alzheimer's disease brain.

Cell Chem Biol. 2026 Apr 23; Epub 2026 Apr 23
Authors: Carnevale LN, Banerjee P, Zhang X, Navarro J, Raspur CK, Patel P, Nakamura T, Schahrer E, Scott H, Lang N, Diedrich JK, Roberts AJ, Yates JR 3rd, Lipton SA
PubMed: 42030932
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Alzheimer's disease immunotherapy and the amyloid hypothesis: when aggregation obscures interpretation.

Lancet. 2026 Apr 23; Epub 2026 Apr 23
Authors: Fox NC, Kohlhaas S, Schott JM
PubMed: 42035783
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Functional Adaptive Longitudinal Reorganization of Superior Parietal Lobule Networks in Amyotrophic Lateral Sclerosis: Evidence Suggesting Compensatory Mechanisms.

Brain Res Bull. 2026 Apr 23;:111900. Epub 2026 Apr 23
Authors: Ghaderi S, Mohammadi S, Kalra S, Batouli SA
PubMed: 42034127
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Direct targeting of C9ORF72 repeat RNA with fluorinated antisense oligonucleotides.

Nucleic Acids Res. 2026 Apr 23;54(8)
Authors: Barber HM, Parasrampuria MA, Jurado-Arjona J, Gamir-Morralla A, Berninger B, González C, Gagnon KT, Damha MJ, Garavís M
PubMed: 42033225
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Divalent siRNA for prion disease.

Nucleic Acids Res. 2026 Apr 23;54(8)
Authors: Gentile JE, Corridon TL, Serack FE, Echeverria D, Kennedy ZC, Gallant-Behm CL, Hassler MR, Kinberger GA, Kelemen MN, Kamath NG, Lian Y, Gross KY, Miller R, DeSouza-Lenz K, Howard M, Guzman K, Chan N, Laversenne V, Curtis D, Fettes K, Lemaitre M, Jackson AL, Yamada K, Alterman JF, Coffey AA, Minikel EV, Khvorova A, Vallabh SM
PubMed: 42033217
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Glycolysis as a central pathological axis in neurodegenerative diseases.

Rev Neurosci. 2026 Apr 23; Epub 2026 Apr 23
Authors: Cheng T, Li M, Yang Y, Rao Z, Yang W
PubMed: 42043421
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Co-aggregation of amyloidogenic proteins in age-related neurodegenerative diseases.

Ageing Res Rev. 2026 Apr 22;118:103148. Epub 2026 Apr 22
Authors: Basha S, Nadkarni PP, Pai AR, Mahato KK
PubMed: 42031321
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Metabolic reprogramming and signalling networks in microglial activation: Implications for neurodegeneration.

Ageing Res Rev. 2026 Apr 22;118:103138. Epub 2026 Apr 22
Authors: El-Hamri MA, Abboussi O
PubMed: 42031319
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Robust validation of neuroimaging and clinical models via the SAR method: A case study based on the ADNI dataset.

Neuroimage. 2026 Apr 22;333:121917. Epub 2026 Apr 22
Authors: Hernández A, Illán IA, Ramírez J, Segovia F, Martínez-Murcia FJ, Levin J, Górriz JM, Alzheimer’s Disease Neuroimaging Initiative
PubMed: 42031084
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In vivo classification of neuropathological disease stages in Parkinson's disease by diffusion tensor imaging.

Neuroimage. 2026 Apr 22;333:121947. Epub 2026 Apr 22
Authors: Müller HP, Bârlescu LA, Sollmann N, Tredici KD, Braak H, Kassubek J
PubMed: 42031082
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Disulfidptosis in neurodegenerative diseases: From redox imbalance to neuronal dysfunction.

Behav Brain Res. 2026 Apr 22;509:116242. Epub 2026 Apr 22
Authors: Shi C, Jia K, Guo Y, Qian S, Wang B, Qiu Y, Dan L, Dang Z, Xue K, Gao F, Zhao L
PubMed: 42031063
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SEC62-mediated ER-Phagy activation alleviates Alzheimer's disease pathology and restores cognitive function in 5×FAD mice.

Mol Ther. 2026 Apr 22; Epub 2026 Apr 22
Authors: Huang J, Wang YB, Wu J, Qian PJ, Shao J, Cao DD, Liu Y, Luo ZG
PubMed: 42026868
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Disease duration-dependent alteration of regulatory natural killer cells in patients with Parkinson's disease.

Parkinsonism Relat Disord. 2026 Apr 22;147:108322. Epub 2026 Apr 22
Authors: Yamanishi Y, Miyaue N, Choudhury ME, Nagai M
PubMed: 42035741
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Astrocytes and Their Role in the Development and Progression of Alzheimer's Disease: Gatekeepers of Neurodegeneration.

J Integr Neurosci. 2026 Apr 22;25(4):49765.
Authors: Svobodova I, Bendova Z, Novotny J
PubMed: 42052757
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An exploratory analysis of plasma biomarkers associated with cerebral amyloid angiopathy.

Neurobiol Aging. 2026 Apr 21;165:1-7. Epub 2026 Apr 21
Authors: Ersözlü E, Meyer F, Preis L, Arslan O, Gref D, Droste L, Hellmann-Regen J, Alzheimer’s Disease Neuroimaging Initiative
PubMed: 42033997
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Microglial Innate Immune Memory: Implications and Research Advances in Central Nervous System Disorders.

Curr Issues Mol Biol. 2026 Apr 21;48(4)
Authors: Song Y, Shu S, Zeng X, Xia M, Liu J, Li L
PubMed: 42042086
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Plant-Derived Peptides with Neuroprotective Activity: Advances and Perspectives in the Prevention of Neurodegenerative Diseases.

ACS Omega. 2026 Apr 21;11(15):22458-22478. Epub 2026 Apr 8
Authors: Maia ME, Carvalho M, Sousa Gomes C, Arruda M, Antunes de Magalhães AJ, Farias D
PubMed: 42040397
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Targeting Lipid Metabolism in Alzheimer's Disease: Emerging Insights and Future Directions.

J Integr Neurosci. 2026 Apr 21;25(4):48436.
Authors: Balakrishnan J, Kannan S, Shanmugam K, Sugasini D
PubMed: 42052762
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Functional Connectivity Alterations in the Cholinergic Neural Circuits of Patients With Alzheimer's Disease: A Donepezil Intervention Study Using Resting-State Functional Magnetic Resonance Imaging.

J Integr Neurosci. 2026 Apr 21;25(4):50039.
Authors: Guo Y, Zhang Z, Chen B, Liu H, Wei F, Liu X, Guo Z
PubMed: 42052761
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A Perspective on Alzheimer's Therapeutics: A Multitarget Approach with Rho-associated Kinase and Histone Deacetylase Inhibitors.

Med Chem. 2026 Apr 21; Epub 2026 Apr 21
Authors: Lopes LF, Tolomeu HV, Vieira RP
PubMed: 42059217
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Polyphenols and physical activity stimulate gut microbiota mediated Nrf2 signaling to combat neurodegeneration.

Pathol Res Pract. 2026 Apr 20;283:156478. Epub 2026 Apr 20
Authors: Wang F
PubMed: 42033865
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Ginkgo Biloba for Alzheimer's Disease: From Mixed Dementia Trials to Biomarker-Confirmed Mild Cognitive Impairment-What Have We Learned over Two Decades, and Is There Finally a Bit of Hope?

Brain Sci. 2026 Apr 20;16(4)
Authors: Yang Y, Kwak YT
PubMed: 42041838
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Predicting future cognitive impairment in preclinical Alzheimer's disease using amyloid PET and MRI: A multisite machine learning study.

Neurobiol Aging. 2026 Apr 19;165:8-23. Epub 2026 Apr 19
Authors: Yang B, Earnest T, Bilgel M, Albert MS, Johnson SC, Davatzikos C, Erus G, Masters CL, Resnick SM, Miller MI, Bakker A, Morris JC, Benzinger TL, Gordon BA, Sotiras A, Alzheimer’s Disease Neuroimaging Initiative, Preclinical Alzheimer’s Disease Consortium
PubMed: 42033998
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Associations of obstructive sleep apnea with A/T/N biomarkers, neuroimaging abnormalities, neurodegenerative progression, and CPAP-related changes in Alzheimer's disease.

Sleep Med. 2026 Apr 18;144:108975. Epub 2026 Apr 18
Authors: Zheng W, Zhou Y, Lu M, Wang Y
PubMed: 42055498
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Design, synthesis and anti-Alzheimer's disease activity evaluation of dual 17β-HSD10 and CDK5/p25 inhibitors based on the naphtho[2,3-b]furan-4,9-dione scaffold.

Eur J Med Chem. 2026 Apr 17;313:118874. Epub 2026 Apr 17
Authors: Dao S, Cui C, He W, Liu E, Zhang L, Tang H
PubMed: 42035670
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MambaKAN: An Interpretable Framework for Alzheimer's Disease Diagnosis via Selective State Space Modeling of Dynamic Functional Connectivity.

Brain Sci. 2026 Apr 17;16(4)
Authors: Gao L, Hu Z
PubMed: 42041829
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Writing Abilities in Primary Progressive Aphasia: A Scoping Literature Review.

Brain Sci. 2026 Apr 17;16(4)
Authors: Esposito V, Conca F, Santi GC, Cappa SF, Catricalà E
PubMed: 42041828
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Brain Delivery of Antibody-Derived Biologicals for Alzheimer's Disease: An Updated Narrative Review.

Antibodies (Basel). 2026 Apr 17;15(2)
Authors: Sumbria RK, Boado RJ
PubMed: 42041396
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Keap1-Nrf2 Signaling Pathway-Mediated Antioxidant Defense in Neurodegenerative Diseases: Mechanisms and Traditional Chinese Medicine Therapeutic Strategies.

Front Biosci (Landmark Ed). 2026 Apr 17;31(4):45233.
Authors: Chen W, Wang J, Li Q, Zhang L, Wu X, Luo S, Xie Y, Guo P
PubMed: 42052844
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Explainable Patient-Level Cognitive Impairment Screening via Temporal, Semantic, and Psycholinguistic Multimodal AI.

J Intell. 2026 Apr 15;14(4)
Authors: Abdullah, Fatima Z, Ruiz MJ, Espinosa-Sosa O, Sánchez-Mejorada CG, Téllez RQ, Rodríguez JL, Sidorov G
PubMed: 42042246
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Sporadic Alzheimer's disease with bipolar-like features: a case report and a brief review of the current research status.

J Zhejiang Univ Sci B. 2026 Apr 15;27(4):416-425.
Authors: Kong L, Yang Y, Zhou W, Hu S
PubMed: 42046874
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Combining cannabidiol and delta-9-tetrahydrocannabinol at a 50:3 ratio - a new therapeutic strategy for APPSwe/PS1ΔE9 transgenic mice?

Neurobiol Aging. 2026 Apr 15;164:79-90. Epub 2026 Apr 15
Authors: Coles M, Rosa Porto R, Chesworth R, Steiner-Lim GZ, Karl T
PubMed: 42054867
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Platelet-Derived Granules and Extracellular Vesicles in Neurodegenerative Diseases: Neurovascular Mechanisms and Clinical Implications.

Cells. 2026 Apr 14;15(8)
Authors: Lee BK, Yoo JR, Jung YS
PubMed: 42041560
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Outer Membrane Vesicles as Systems-Level Drivers of Neuroinflammation, Metabolic Dysfunction, and Proteinopathy in Alzheimer's Disease.

Cells. 2026 Apr 14;15(8)
Authors: Delbaz A, St John JA
PubMed: 42041558
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Effect of α-Synuclein Overexpression on NAPP-129 and TLQP-62 in Rat Brain and Plasma.

Med Sci (Basel). 2026 Apr 13;14(2)
Authors: Manai AL, Noli B, Anjum A, Manca E, Casu MA, Pardon MC, Cocco C
PubMed: 42029619
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Zebrafish (Danio rerio) as a Model for Neurodegenerative Disease Research: Mechanisms, Biomarkers, and Translational Promise.

CNS Neurol Disord Drug Targets. 2026 Apr 13; Epub 2026 Apr 13
Authors: Khan N, Doshi G
PubMed: 42051098
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Therapeutic Innovations in Parkinson's and Alzheimer's Disease: Molecular Mechanisms and Emerging Strategies.

CNS Neurol Disord Drug Targets. 2026 Apr 13; Epub 2026 Apr 13
Authors: Kasthuri S, Padmavathi S, Jeevitha M, Rajangam J
PubMed: 42051097
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In Silico Design and Evaluation of Diosmin Analogs for Targeting Peroxisome Proliferator-activated Receptor γ (PPAR-γ) Against Alzheimer's Disease.

Curr Neuropharmacol. 2026 Apr 13; Epub 2026 Apr 13
Authors: Sun Y, Chan TW, Liao W, Li M, Mao X, Feng Y, Rong J, Zhao J
PubMed: 42051092
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Cognitive Testing in Spanish Older Adults: A Scoping Review.

Geriatrics (Basel). 2026 Apr 10;11(2)
Authors: Sáez-González L, Martínez LA, Blázquez-Abellán G, de Lara JA, Martinez-Garcia RM, Castro-Vázquez L
PubMed: 42042101
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Schisandra chinensis Pomace Attenuates Scopolamine-Induced Cholinergic Dysfunction Associated with Changes in BDNF and JNK Signaling.

Curr Issues Mol Biol. 2026 Apr 10;48(4)
Authors: Yoon JH, Lim SH, Lee IS, Jang YK, Park SJ, Lee SJ, Im S, Park JH, Park H, Maeng S, Shin J
PubMed: 42042048
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Deficient Visuospatial Incidental and Intentional Memory in Cognitively Healthy Middle-Aged First-Degree Descendants of Alzheimer's Disease Patients.

Brain Sci. 2026 Apr 10;16(4)
Authors: Álvarez-Huante CG, Rincón-Ortega MF, Palomares-Vallejo EJ, Téllez-Anguiano AD, Junco-Muñoz ML, López-Vázquez MÁ, Olvera-Cortés ME
PubMed: 42041814
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From Lipids to Mitochondria: Shared Metabolic Alterations in Obesity and Alzheimer's Disease.

Cells. 2026 Apr 10;15(8)
Authors: Uranga RM, Allani SK
PubMed: 42041540
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Association Between the Color Kanji Pick-Out Test App Performance and Cognitive Frailty as a Potential Early Screening Marker for Cognitive Decline.

Geriatrics (Basel). 2026 Apr 9;11(2)
Authors: Goda A, Nakano H, Kikuchi Y, Katsurasako T, Mori K, Kubo A, Nonaka K, Iwamoto K, Mitsumaru N, Shimura T, Murata S
PubMed: 42042097
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Integrated Analysis of Cerebral Small Vessel Disease and Facial Soft-Tissue Markers in the Alzheimer's Disease Continuum.

Brain Sci. 2026 Apr 9;16(4)
Authors: Bernetti C, Di Gennaro G, Roberti R, Ricci M, Pipitone F, Profilo M, Motolese F, Calandrelli R, Pilato F, Di Lazzaro V, Beomonte Zobel B, Mallio CA
PubMed: 42041811
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Sustained Palmitoylethanolamide Infusion Restores Incentive Motivation and Synaptic Plasticity in the Tg2576 Mouse Model of Alzheimer's Disease.

Cells. 2026 Apr 9;15(8)
Authors: Panuccio A, Yurtsever ZN, Cutuli D, Giacovazzo G, Decandia D, Tortolani D, Landolfo E, Oddi S, Maccarrone M, Petrosini L, Coccurello R
PubMed: 42041537
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Immunosenescence and Inflammaging as Drivers of Neurodegeneration: Cellular Mechanisms, Neuroimmune Crosstalk, and Therapeutic Implications.

Cells. 2026 Apr 8;15(8)
Authors: Bertoni G, Ristori S, Monti D
PubMed: 42041525
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Effect of High-Salt Diet on Memory and Behavior in Mice Expressing Human Apolipoprotein Epsilon-4 (APOE4) Allele.

NeuroSci. 2026 Apr 7;7(2)
Authors: Abdulmoniem R, Rivers M, Carter G, Khundmiri SJ, O'Neil JN
PubMed: 42042624
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Quinoline/thiazole compounds as selective acetylcholinesterase inhibitors: synthesis and biological assessment.

RSC Med Chem. 2026 Apr 7; Epub 2026 Apr 7
Authors: Kurban B, Osmaniye D, Levent S, Özkay Y, Kaplancıklı ZA
PubMed: 42037743
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mTOR Signalling in Neurodegenerative Disorders: Unveiling Key Factors, Mechanistic Insights, and Possible Therapeutic Interventions.

Cell Physiol Biochem. 2026 Apr 6;60(2):136-174.
Authors: Jha NK, Chauhan P, Abomughaid MM, Avinash D, Almutary AG, Lakhanpal S, Singh A, Sulaimani GM, Al-Kuraishy HM, Mohammed HA, Misra J, Thakur K, Kumar D
PubMed: 42057546
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Life course neighborhood conditions and change: a 20-year examination of neighborhood context and associations with Alzheimer's disease biomarkers in late life.

Alzheimers Dement. 2026 Apr;22(4):e71382.
Authors: Clark AL, Hamlin AM
PubMed: 42029424
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Visual memory correlates with AD biomarkers in cognitively unimpaired individuals.

Alzheimers Dement. 2026 Apr;22(4):e71417.
Authors: James TA, Zhao L, Xu H, Wu J, Schweidel DA, Goldstein FC, Levey AI, Qiu D, Loring DW, Hanfelt JJ, Lah JJ
PubMed: 42029420
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Locus coeruleus degeneration is associated with cortical tau deposition and cognitive decline in older adults at familial risk of Alzheimer's disease.

Alzheimers Dement. 2026 Apr;22(4):e71427.
Authors: Wearn A, Onuska KM, Shanks HR, Gaurav R, Lehéricy S, Baracchini G, Hughes C, Tremblay-Mercier J, Narayanan S, Breitner J, Poirier J, Schmitz TW, Turner GR, Spreng RN, PREVENT‐AD Research Group
PubMed: 42029407
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Beyond AUC: Clinical interpretability of depression-MRI-machine learning analyses in Alzheimer's disease.

Alzheimers Dement. 2026 Apr;22(4):e71435.
Authors: Deng W, Xie Y
PubMed: 42029395
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Infection of 5xFAD mice with a mouse-adapted SARS-CoV-2 does not alter Alzheimer's disease neuropathology yet induces widespread changes in gene expression across diverse cell types.

Alzheimers Dement. 2026 Apr;22(4):e71394.
Authors: Furman S, Zayou L, Tsourmas KI, Javonillo DI, Olivarria GM, Cheng Y, Pachow C, Fernandez K, Le L, Edwards RA, Nicholas DA, Sanchez GP, Baric RS, Green KN, Lane TE
PubMed: 42029189
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[A "prion mechanism" involved in the progression of Parkinson's disease: towards innovative therapeutic approaches?].

Med Sci (Paris). 2026 Apr;42(4):385-388. Epub 2026 Apr 24
Authors: Baron T
PubMed: 42028943
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[Protein aggregation: at the origins of neurodegenerative diseases].

Med Sci (Paris). 2026 Apr;42(4):383-384. Epub 2026 Apr 24
Authors: Baron T
PubMed: 42028942
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[Protein aggregation: from the prion exception to a general paradigm of neurodegeneration].

Med Sci (Paris). 2026 Apr;42(4):323-324. Epub 2026 Apr 24
Authors: Beringue V
PubMed: 42028928
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Outreach, Recruitment and Engagement Cores of NIA-designated Alzheimer's Disease Research Centers: Current strategies and future directions.

Alzheimers Dement. 2026 Apr;22(4):e71238.
Authors: Chan CK, Glover CM, Parker M, Grill JD, Langbaum JB, Morhardt DJ, Okonkwo O, Farrar-Edwards D, Wang S
PubMed: 42028802
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Molecular Pathogenesis of Memory Impairment in Parkinson's Disease: An Exploration of Underlying Mechanisms.

Health Sci Rep. 2026 Apr;9(4):e72024. Epub 2026 Apr 21
Authors: Pourfridoni M, Hakemi Z, Mashayekhi-Sardoo H, Baghcheghi Y
PubMed: 42028419
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Structural and biochemical basis of ROC-dependent activation of LRRK2.

PNAS Nexus. 2026 Apr;5(4):pgag112. Epub 2026 Apr 9
Authors: Park Y, Wu C, Tennessen K, Wan L, Hoang NC, Hoang CW, Liao J, Hoang QQ
PubMed: 42028153
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Endothelial NAD+ depletion drives vascular senescence and neuroinflammation via mtDNA-cGAS/STING-CD38 signaling in Alzheimer's disease.

Alzheimers Dement. 2026 Apr;22(4):e71423.
Authors: Luo QH, Li F, Yang L, Pan HQ, Zhu WP, Hu P, Tao CM, Yin M, Zhang S, Liao QY, Chen ZH, Shu HX, Zhu XY, Yan TF, Liu X, Tu JL, Zhu XG
PubMed: 42033099
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Differential associations between traumatic brain injury severity and four dementia phenotypes in military veterans.

Alzheimers Dement. 2026 Apr;22(4):e71370.
Authors: Merritt VC, Valocchi E, Lopez FV, Asimakopoulos G, Clark AL, Kodama L, Jak AJ, Liu L, Chanfreau-Coffinier C
PubMed: 42033091
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Tau Oligomers Induce Brain Endothelial Cell Hyperpermeability and Increase NLRP3 Inflammasome Signaling and MMP-9 Activity.

Microcirculation. 2026 Apr;33(3):e70059.
Authors: Seplovich G, Muthusamy S, Anderson A, Waithe OY, Kobeissy F, Wang KK, Tharakan B
PubMed: 42035323
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Cold Climate and Alzheimer's Disease: A Narrative Review of Biomedical and Environmental Mechanisms.

Acta Neurol Taiwan. 2026 Apr 1;35(2):70-78. Epub 2026 Apr 24
Authors: Abdel-Sater KA
PubMed: 42033804
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Use of anti-amyloid-β monoclonal antibodies in persons with Down syndrome Alzheimer's disease.

Alzheimers Dement. 2026 Apr;22(4):e71404.
Authors: Farrell C, Saini F, Beidas MM, Ryan NS, Strydom A, Wiseman FK
PubMed: 42043831
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Genetic correlation analysis of Alzheimer's disease and stroke implicates PHLPP1 as a shared locus in individuals of African ancestry.

Alzheimers Dement. 2026 Apr;22(4):e71433.
Authors: Ray NR, Kurup J, Kumar A, Rajabli F, Wang L, Xu W, Jin F, Yilmaz E, Kizil C, Bertholim-Nasciben L, Moura S, Ramirez AM, Baiyewu O, Griswold AJ, Coker M, Scott KM, Akinwande K, Adams LD, Diala S, Whitehead PG, McCauley JL, Ogunronbi M, Hamilton-Nelson KL, Damasceno A, Zaman AF, Blanton SH, Akpalu A, Cuccaro ML, Wahab K, McInerney KF, Nuytemans K, Obiako R, Mena PR, Okubadejo N, Martinez IM, Zewde YZ, Gugssa SA, Sarfo FS, Kalaria R, Ndetei DM, Williams SM, Caban-Holt A, ADGC, AfDC, Tosto G, Haines JL, Akinyemi RO, Ogunniyi A, Byrd GS, Bush WS, Kunkle BW, Vance JM, Pericak-Vance MA, Reitz C
PubMed: 42043782
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Human iPSC-derived GABAergic interneuron transplantation restores circuit balance and cognitive function in an Alzheimer's disease model.

Alzheimers Dement. 2026 Apr;22(4):e71378.
Authors: Zhang X, Wang G, Chen H, Sun Y, Wangliu Z, Wang L, Sun M, Liu Q, Zhang X
PubMed: 42043780
Submit Comment

How PM2.5 drives dementia: emerging mechanisms and unanswered questions.

Life Med. 2026 Apr;5(2):lnag007. Epub 2026 Feb 2
Authors: Defrancesco AD, Yi C, Oliver BG, Chen H
PubMed: 42040207
Submit Comment

Feasibility of identifying factors related to Alzheimer's disease and related dementia in real-world data.

JAMIA Open. 2026 Apr;9(2):ooag060. Epub 2026 Apr 24
Authors: Huang Y, Li Q, Chen A, Li Y, Chuang YN, Hu X, Guo SJ, He X, Pang Y, Zhou J, Wu Y, Guo Y, Bian J
PubMed: 42040178
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The adherence of memory clinics to consensus recommendations for dementia diagnosis: A multicentric study in Italy.

Alzheimers Dement. 2026 Apr;22(4):e71432.
Authors: Festari C, Singh Solorzano C, Orini S, Castagna E, Cotta Ramusino M, D'Antonio F, Di Crosta A, Masòtino A, Massa F, Mazzonetto A, Panigutti M, Ravì N, Pievani M, Bonanni L, Bruno G, Cagnin A, Gatta R, Frisoni GB
PubMed: 42036798
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Sleep duration and amyloid status moderate the association between mood symptoms and amygdalar tau in preclinical Alzheimer's disease.

Alzheimers Dement. 2026 Apr;22(4):e71447.
Authors: Bonta KM, Li JS, Tun SM, Fredericks CA
PubMed: 42036797
Submit Comment

AS1842856 Reduces β-Amyloid Burden via Inhibiting PLA2G4A-Mediated Lysosomal Dysfunction in APP/PS1 Mice.

CNS Neurosci Ther. 2026 Apr;32(4):e70910.
Authors: He DL, Wu Z, Jia RJ, Wu TY, Qiu YM, Fan YG
PubMed: 42047940
Submit Comment

System changes to empower primary care in Alzheimer's disease detection and care.

Alzheimers Dement. 2026 Apr;22(4):e71276.
Authors: Phares S, Kremer I, Wall JK, Wood J, Baumgart M, Dickson S, Fickie M, Hubbard T, Jannati A, Monane M, Rivet C, Hirsch G
PubMed: 42047299
Submit Comment

Multiscale metabolic covariance networks uncover stage-specific biomarker signatures across the Alzheimer's disease continuum.

Alzheimers Dement. 2026 Apr;22(4):e71218.
Authors: Chong Chie JA, Persohn SA, Pandey RS, Simcox OR, Carter G, Salama P, Territo PR, Alzheimer's Disease Neuroimaging Initiative
PubMed: 42047294
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Plasma Biomarkers and Clinical Outcomes in Early-Onset Dementia.

JAMA Netw Open. 2026 Apr 1;9(4):e269687.
Authors: Jang H, Lee SM, Kim HJ, Jung NY, Zetterberg H, Blennow K, Apostolova LG, Moon SY, Kim EJ, Longitudinal Study of Early-Onset Dementia and Family Members (LEAF) Investigators
PubMed: 42054026
Submit Comment

Association Between Serum Adropin Levels and Cognitive Impairment in the Elderly: A Cross-Sectional Study.

Clin Neuropsychiatry. 2026 Apr;23(2):144-153.
Authors: Abousamra S, El Arman MM, Arafa Ghazi H, El-Sobky HS, Hatata E
PubMed: 42052221
Submit Comment

Dynamic trajectories of neuropsychiatric symptoms predict Alzheimer's disease risk and clinical phenotypes.

Gen Psychiatr. 2026 Apr;39:e70018. Epub 2026 Apr 26
Authors: Liu W, Wang Y, Shi Y, Huang L, Tan C, Tan L, Xu W, Alzheimer's Disease Neuroimaging Initiative
PubMed: 42052139
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The Need for Standardized Data Collection to Improve Harmonization and Pooling of Information About Modifiable Risk Factors for Alzheimer's Diseases in Italian Clinical Studies: A Systematic Review.

Geriatrics (Basel). 2026 Mar 31;11(2)
Authors: Allegra P, Lodico M, Migliazzo C, Tarantino D, Piccoli T, Vanacore N, Salemi G, Maniscalco L, Matranga D
PubMed: 42042094
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Exploring Early Neurodegeneration Through Fasting-Induced Metabolic Signatures and High-Sensitivity Biomarkers.

Curr Issues Mol Biol. 2026 Mar 28;48(4)
Authors: Cacciabaudo F, Agnello L, Gambino CM, Accardi G, Masucci A, Tamburello M, Vassallo R, Ciaccio M
PubMed: 42042018
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Alpha-Lipoic Acid and Biotin in Neurodegenerative Diseases: Convergent Mechanistic Insights from Preclinical Models to Clinical Perspectives.

Neurol Int. 2026 Mar 26;18(4)
Authors: Aguilera-Méndez A, Aguilera-Manuel K, Saavedra-Molina A, Ríos-Chávez P, Villafaña S, Nieto-Aguilar R, Godínez-Hernández D, Ortega-Cuellar D, Palomera-Sanchez Z, Gauthereau-Torres M
PubMed: 42042751
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Distant Origins of Local Pathologies: Rethinking the Systemic Roots of Alzheimer's Disease and Beyond.

Iran J Med Sci. 2026 Mar;51(3):157-159. Epub 2026 Mar 1
Authors: Ghasemi Y
PubMed: 42039220
Submit Comment

Non-fluent agrammatic variant of primary progressive aphasia in a bilingual Mandarin/English speaker: a case report.

Arch Clin Neuropsychol. 2026 Feb 27;41(3)
Authors: Zhang BY, Ortiz BL, Peery S
PubMed: 42041196
Submit Comment

Current perspectives on neurodegenerative diseases: from clinical autopsy to precision medicine.

Rev Esp Patol. 2026;59(2):100876.
Authors: Rábano A
PubMed: 42031434
Submit Comment

Lost before forgetting: objective driving metrics track navigation deficits tied to preclinical Alzheimer's disease.

Innov Aging. 2026;10(5):igag013. Epub 2026 Feb 18
Authors: Zhu Y, Singh RK, Bekena S, Brown DC, Chen C, Blake M, Trani JF, Babulal GM
PubMed: 42028229
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From clinical judgment to biology: a clinician's opinion on the use of blood-based biomarkers in Alzheimer's disease.

Front Neurol. 2026;17:1804163. Epub 2026 Apr 8
Authors: Medina-Rioja R, Llorente-Vidrio A, Ruiz-Garcia R, Rodríguez-Violante M
PubMed: 42028213
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Traditional Chinese Medicine for Alzheimer's Disease: Current Evidence and Chemometric Approaches for Multi-Target Evaluation.

Neuropsychiatr Dis Treat. 2026;22:590661. Epub 2026 Apr 18
Authors: Sun X, Yang L, Wang X
PubMed: 42028071
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Effects of exercise on cognitive function in older patients with Alzheimer's disease: a meta-regression and meta-analysis.

Front Public Health. 2026;14:1793973. Epub 2026 Apr 8
Authors: Xu F, Zhang Y, Tan D, He Y, Fei Q, Xu K
PubMed: 42027916
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Dementia screening protocol for primary care in South America: a Delphi consensus study.

Front Public Health. 2026;14:1798111. Epub 2026 Apr 8
Authors: Custodio B, Montesinos R, Caramelli P, Calandri I, Brucki SM, Suemoto CK, Allegri R, Slachevsky A, Parodi JF, Morsch P, Willets C, Cuba Fuentes MS, Custodio N
PubMed: 42027915
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Research progress on Alzheimer's disease vaccines: from Aβ-targeted approaches to clinical translation.

Front Aging. 2026;7:1794820. Epub 2026 Apr 8
Authors: Han Y, Luo G, Huang Y, Cai Z, Su W, Kuang X, Huang L, Wei L, Ming F, He Z, Yang Z, Wang J, Jiang W, Xiao C, Hu Q, Yan J
PubMed: 42027759
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Personalized audiovisual gamma stimulation enhances neural connectivity and entrainment beyond fixed 40 Hz protocols.

Front Neurosci. 2026;20:1787255. Epub 2026 Apr 8
Authors: Jeon JY, Lee H, Ji M, Kim JS, Ahn DH
PubMed: 42027686
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The role of nutrition and multimodal lifestyle interventions in Alzheimer's prevention and management: a mini-review.

Front Nutr. 2026;13:1818913. Epub 2026 Apr 8
Authors: Zhang H, Liu C, Yuan X, Yin H
PubMed: 42027570
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Bioactive compounds and exercise in aging and neurodegeneration: mechanistic insights from the gut-brain-metabolic axis.

Front Nutr. 2026;13:1781176. Epub 2026 Apr 8
Authors: Feng ZT, Zhang YY, Xue CX
PubMed: 42027568
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Fixel-based analysis and free-water metrics in subjective cognitive decline and cognitive impairment no dementia.

Alzheimers Dement (Amst). 2026;18:e70308. Epub 2026 Apr 21
Authors: Lee ZL, Tee M, Tan WY, Huang X, Cui J, Billaud CH, Yu J, Hilal S
PubMed: 42027252
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Brain atrophy and clinical diagnosis independently predict default mode network failure across the Alzheimer's disease continuum.

Alzheimers Dement (Amst). 2026;18:e70343. Epub 2026 Apr 21
Authors: Alghamdi M, von Wegner F, Chan DK, Green M, Alzheimer's Disease Neuroimaging Initiative
PubMed: 42027251
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Deep medullary vein abnormalities associated with cognitive function and Alzheimer's disease plasma biomarkers in dementia-free older adults: A population-based study.

Alzheimers Dement (Amst). 2026;18(2):e70320. Epub 2026 Mar 30
Authors: Yin D, Wang J, Li C, Wang X, Wang Y, Xie Q, Tian N, Chen Z, Sun X, Wang Y, Hou T, Cong L, Zhou L, Du Y, Song L, Qiu C
PubMed: 42040899
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Clinical staging in Swedish primary care using the Amsterdam Instrumental Activities of Daily Living Questionnaire.

Alzheimers Dement (Amst). 2026;18:e70344. Epub 2026 Apr 24
Authors: Fawad A, van der Landen SM, Tideman P, van der Putten-Toorenburg A, Butterbrod E, Smith R, van Westen D, Calling S, Midlöv P, Mattsson-Carlgren N, Borgström Bolmsjö B, Stomrud E, Nilsson MH, Hansson O, Sikkes SA, Palmqvist S
PubMed: 42040886
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MRI evaluation of cerebral perivascular spaces predicts amyloid-related imaging abnormalities risk in preclinical Alzheimer's disease.

Front Dement. 2026;5:1719740. Epub 2026 Apr 9
Authors: Bigjahan B, Cavallari M, Barisano G
PubMed: 42040755
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Beyond the cut-off: measurement bias, calibration, and fairness in mild cognitive impairment screening.

Front Med (Lausanne). 2026;13:1814214. Epub 2026 Apr 10
Authors: Jerjes W, Harding D
PubMed: 42040570
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Functional and genetic divergence of aging-related TOMM40 polymorphisms in Alzheimer's disease: an integrative bioinformatics and systematic review with meta-analysis and trial sequential analysis.

Front Neurosci. 2026;20:1772368. Epub 2026 Apr 10
Authors: Li S, Luo Y, Shi S, Ding Y
PubMed: 42040345
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Retraction: Early detection and classification of Alzheimer's disease through data fusion of MRI and DTI images using the YOLOv11 neural network.

Front Neurosci. 2026;20:1845919. Epub 2026 Apr 10
Authors: Frontiers Editorial Office
PubMed: 42040334
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Sleep phenotypes and subjective cognitive decline in the Hispanic Community Health Study/Study of Latinos.

Sleep Adv. 2026;7(2):zpag032. Epub 2026 Mar 12
Authors: González KA, Membreno R, Tarraf W, Stickel AM, DeCarli C, Marquez F, Agudelo C, Patel SR, Gallo LC, Bubu O, Daviglus M, Testai FD, Sotres-Alvarez D, Penedo FJ, Junco B, González HM, Ramos AR
PubMed: 42040192
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Monoclonal antibodies and small molecules: on the cutting edge of Alzheimer's disease therapy.

Front Cell Dev Biol. 2026;14:1766762. Epub 2026 Apr 9
Authors: Ouro A, Ben-Dor GA, Debasa-Mouce M, Gulkarov S, De Leon J, Castro-Mosquera M, Sobrino T, Bougea A, Reiss AB
PubMed: 42039150
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Restoring oscillatory dynamics in Alzheimer's disease: A laminar whole-brain model of serotonergic psychedelic effects.

Netw Neurosci. 2026;10(2):303-328. Epub 2026 Apr 22
Authors: Gendra JC, Lopez-Sola E, Castaldo F, Lleal-Custey È, Sanchez-Todo R, Vohryzek J, Salvador R, Andrzejak RG, Ruffini G, Alzheimer’s Disease Neuroimaging Initiative
PubMed: 42039100
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Research on Alzheimer's disease MRI image classification based on spatial attention mechanism.

Front Aging Neurosci. 2026;18:1657578. Epub 2026 Apr 10
Authors: Zhao S, Shi H, Guan C, Zeng Q, Zhang C, Wan Y
PubMed: 42038702
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Neuroprotective effects of isoflavone-enriched soybean leaves (Glycine Max) on scopolamine-induced memory deficits in C57BL/6 mice via antioxidative mechanisms.

Front Aging Neurosci. 2026;18:1787268. Epub 2026 Apr 10
Authors: Do YJ, Kim SY, Go Y, Lee YH, Park KH, Oh TW
PubMed: 42038699
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The therapeutic efficacy of transcranial direct current stimulation in managing Alzheimer's disease: a systematic review and meta-analysis.

Front Aging Neurosci. 2026;18:1726469. Epub 2026 Apr 10
Authors: Wang X, Tian L
PubMed: 42038695
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Dysregulated glucose metabolism in the visual cortex of human subjects with mild cognitive impairment and Alzheimer's disease.

Front Aging Neurosci. 2026;18:1710075. Epub 2026 Apr 9
Authors: Mjaaseth UN, Hsu MF, Arballo J, Haj FG, Patel V
PubMed: 42038694
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Pink1 at the crossroads of aging, exercise, and diet in Parkinson's disease: a mechanistic review.

Front Aging Neurosci. 2026;18:1738559. Epub 2026 Apr 10
Authors: Lin Y, Wen DT
PubMed: 42038693
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Development of Alzheimer's disease risk score for future integrated primary care: a white-box approach.

Front Aging Neurosci. 2026;18:1759273. Epub 2026 Apr 10
Authors: Wiranto Y, Setiawan D, Watts A, Ashourvan A
PubMed: 42038691
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Design of a deep learning prediction model for Alzheimer's and Parkinson's Disease using MRI images.

Front Artif Intell. 2026;9:1777236. Epub 2026 Apr 9
Authors: K V, Jaisankar N
PubMed: 42038539
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Cynanchum bungei Decne-derived extracellular vesicles alleviate cognitive impairment and pathological damage in Alzheimer's disease.

Front Cell Neurosci. 2026;20:1798965. Epub 2026 Apr 10
Authors: Hong R, Han J, Dong F, Kalsoom UE, Cao C, Zhou A, Wu Q, Qu X
PubMed: 42038337
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Intestinal inflammation promotes neuroinflammation and PD-associated nigrostriatal pathology independently of LRRK2 G2019S kinase activity.

Front Cell Neurosci. 2026;20:1794784. Epub 2026 Apr 10
Authors: Merchak AR, Herrick MK, Houser MC, Keating CE, Chang J, Tansey MG
PubMed: 42038336
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Correction to: A passive and objective measure of recognition memory in mild cognitive impairment using Fastball memory assessment.

Brain Commun. 2026;8(2):fcag147. Epub 2026 Apr 24
Authors:
PubMed: 42038258
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Depression as an early symptom and risk factor of dementia - a narrative review.

Front Psychiatry. 2026;17:1786179. Epub 2026 Apr 10
Authors: Permoda-Pachuta A, Obszanski P, Grad Z, Futyma-Jędrzejewska M, Ziemecki P, Dominiak M
PubMed: 42038088
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Research progress in neuroimaging of sporadic early-onset Alzheimer's disease.

Front Neurol. 2026;17:1788814. Epub 2026 Apr 10
Authors: Zhang X, Yang C
PubMed: 42037717
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Detecting CSF-validated Alzheimer's disease from spontaneous speech in German: an interpretable end-to-end machine-learning framework.

Front Neurol. 2026;17:1780783. Epub 2026 Apr 9
Authors: Wiechmann D, Kerz E, Albrecht M, Qiao Y, Pinho J, Reetz K, Costa AS
PubMed: 42037712
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Correction: The impact of bright light therapy on non-motor symptoms in patients with Parkinson's disease: a systematic review and meta-analysis.

Front Neurol. 2026;17:1823587. Epub 2026 Apr 10
Authors: Geng J, Yu H, Tan L
PubMed: 42037702
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Differential associations of NFL and GFAP with neuropsychiatric symptoms by amyloid status across the Alzheimer's disease continuum.

Front Neurol. 2026;17:1782816. Epub 2026 Apr 10
Authors: Wu J, Jiang H, Wang R, Lv X, Tang F, Chai X, Zhu Y, Cheng Z, Wu Y, Tang Q
PubMed: 42037699
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Frailty status and the risk of dementia, Alzheimer's disease: a meta-analysis of observational studies.

Front Neurol. 2026;17:1798080. Epub 2026 Apr 10
Authors: Zhao Y, Zeng M, Zhang S, Peng D
PubMed: 42037682
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Targeting VDR-RXR heterodimerization in neurodegenerative diseases: a hypothetical framework for combined vitamin D3 and vitamin A therapy.

Front Neurol. 2026;17:1754364. Epub 2026 Apr 10
Authors: Sirajo MU, Obie R, Mukhtar AI, Abdullahi NM, Taniyohwo EM, Oyem JC, Badamasi IM
PubMed: 42037680
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Novel insight into PINK1/parkin-associated autophagy implicated in Parkinson disease.

Transl Neurosci. 2026 Jan;17(1):20250386. Epub 2026 Apr 20
Authors: Stegmüller J
PubMed: 42046651
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Multi-omic phenotyping of MAPT V337M neurons reveals early changes in axonogenesis and tau phosphorylation.

NPJ Dement. 2026;2(1):24. Epub 2026 Apr 25
Authors: Mohl GA, Dixon G, Marzette E, McKetney J, Samelson AJ, Serras CP, Jin J, Ariqat N, Keys A, Chavira C, Li A, Boggess SC, Swaney DL, Kampmann M
PubMed: 42046563
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In-tissue structural biology of the brain: A focus on Alzheimer's disease pathology.

Methods Enzymol. 2026;729:69-106. Epub 2026 Feb 24
Authors: Jenkins J, Gilbert MA, Fatima N, O'Sullivan TJ, Thompson WG, Frank RA
PubMed: 42055645
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How to prepare Alzheimer's amyloid-β(1-42) oligomer samples with sufficient quantity and quality for biophysical and solid-state NMR measurements.

Methods Enzymol. 2026;729:419-433. Epub 2026 Feb 24
Authors: Dinakarapandian DM, Watzlawik JO, Sudarshan TR, Rosenberry TL, Paravastu AK
PubMed: 42055644
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All-atom MD simulations of amyloid-membrane interactions: Setup, execution, and analysis.

Methods Enzymol. 2026;729:389-417. Epub 2026 Mar 9
Authors: Bundschuh BF, Kley F, Fatafta H, Strodel B
PubMed: 42055643
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Application of EPR spectroscopy in the structural studies of Aβ oligomers and fibrils.

Methods Enzymol. 2026;729:361-388. Epub 2026 Feb 3
Authors: Portugal Barron D, Guo Z
PubMed: 42055642
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Cryo-EM structure determination of amyloid fibrils: Methodology, insights, and practical tools.

Methods Enzymol. 2026;729:35-68. Epub 2026 Mar 17
Authors: Sommerhage S, Lammert J, Camino JD, Schröder GF
PubMed: 42055641
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Single-molecule fluorescence spectroscopy and imaging of heterogeneous amyloid β aggregation.

Methods Enzymol. 2026;729:309-332. Epub 2026 Jan 28
Authors: Kim JY, Song E, Aniana A, Louis JM, Chung HS
PubMed: 42055639
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Methods for characterizing the individual filament structures of amyloid peptide assemblies using atomic force microscopy.

Methods Enzymol. 2026;729:281-308. Epub 2026 Feb 3
Authors: Shahbaz A, Weetman SL, Chitty C, Xue WF
PubMed: 42055638
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Time-resolved solid-state nuclear magnetic resonance studies of amyloid-β oligomer formation.

Methods Enzymol. 2026;729:259-280. Epub 2026 Jan 28
Authors: Tycko R
PubMed: 42055637
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Characterizations of the β-amyloid (Aβ)-membrane interaction intermediates.

Methods Enzymol. 2026;729:231-258. Epub 2026 Jan 28
Authors: Kengwerere MK, Wang T, Qiang W
PubMed: 42055636
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Opportunities and challenges in the use of pressure-jump NMR to study Aβ and protein oligomerization.

Methods Enzymol. 2026;729:179-230. Epub 2026 Feb 4
Authors: Gelenter MD, Li T, Anfinrud P, Bax A
PubMed: 42055635
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Dynamics studies of side-chains and hydration shells in amyloid-β fibrils using deuterium and oxygen-17 solid-state NMR.

Methods Enzymol. 2026;729:145-177. Epub 2026 Feb 5
Authors: Vugmeyster L, Ostrovsky D
PubMed: 42055634
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Cryo-EM methods to study binding between amyloid fibrils and chemical compounds.

Methods Enzymol. 2026;729:107-144. Epub 2026 Jan 28
Authors: Zhao Q, Liu K, Li D, Liu C
PubMed: 42055633
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Amyloid extraction from neurodegenerative disease tissues for structural studies.

Methods Enzymol. 2026;729:1-33. Epub 2026 Feb 3
Authors: Alhadidy MM, Hinton TV, Ernst KN, Yang Y
PubMed: 42055632
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[Efficacy of choline alfoscerate treatment for subjective cognitive impairment in first-degree relatives of patients with Alzheimer's disease: Results of a comparative 5-year study].

Zh Nevrol Psikhiatr Im S S Korsakova. 2026;126(4. Vyp. 2):92-99.
Authors: Selezneva ND, Roshchina IF, Gavrilova SI
PubMed: 42054337
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[Myoclonus in Alzheimer's disease].

Zh Nevrol Psikhiatr Im S S Korsakova. 2026;126(4. Vyp. 2):63-69.
Authors: Bogolepova AN, Burd SG, Lebedeva AV, Rubleva YV, Kovalenko EA, Machnovich EV, Osinovskaya NA, Pantina NV, Kovaleva II, Bokitko TA, Alexeeva GA
PubMed: 42054333
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[Sleep disorders in Alzheimer's disease].

Zh Nevrol Psikhiatr Im S S Korsakova. 2026;126(4. Vyp. 2):56-62.
Authors: Kolmakova KA, Lobzin VY, Emelin AY
PubMed: 42054332
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[Alzheimer's disease and bilingualism].

Zh Nevrol Psikhiatr Im S S Korsakova. 2026;126(4. Vyp. 2):40-46.
Authors: Syromyatnikov NN, Preobrazhenskaya IS
PubMed: 42054330
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[Alzheimer's disease: Diagnostic criteria and their evolution].

Zh Nevrol Psikhiatr Im S S Korsakova. 2026;126(4. Vyp. 2):29-39.
Authors: Vorobev SV, Emelin AY, Yanishevskiy SN, Tantasheva AM
PubMed: 42054329
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Brain network analysis in Alzheimer's disease and mild cognitive impairment using high-density diffuse optical tomography.

Imaging Neurosci (Camb). 2026;4 Epub 2026 Apr 24
Authors: Butters E, Collins-Jones L, Mesquita RC, Acharya D, McKiernan E, Laurell AA, Low A, Srinivasan S, O'Brien JT, Su L, Bale G
PubMed: 42052506
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Early detection of Alzheimer's disease via multimodal MRI and machine learning.

Front Aging Neurosci. 2026;18:1794982. Epub 2026 Apr 13
Authors: Yuan J, Liu Y, Jin J, Li S, Zhang Y
PubMed: 42052380
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Plasma chaperone-mediated autophagy associated protein HSPA8 combined with white matter hyperintensities serves as the predictive marker of early-stage Alzheimer's disease.

Front Aging Neurosci. 2026;18:1753692. Epub 2026 Apr 13
Authors: Yan X, Liang C, Zhou Y, Hong G, Li C, Wang K, Huang Y, Xiao X
PubMed: 42052379
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Brexpiprazole for Agitation in Patients with Alzheimer's Dementia with and without Co-Occurring Psychosis: Post Hoc Analysis of Short- and Long-Term Trials.

Neuropsychiatr Dis Treat. 2026;22:586701. Epub 2026 Apr 21
Authors: Tariot PN, Chumki SR, Wang D, Such P, Palma AM, Zhang Z, Montano CB
PubMed: 42052145
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Amyotrophic lateral sclerosis and chronic inflammatory demyelinating polyneuropathy coexistence in a patient with a C9orf72 variant: case report.

Front Dement. 2026;5:1785124. Epub 2026 Apr 13
Authors: File C, Price AM, Ahmad R, Shanina E, Sun RL
PubMed: 42051912
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Neutrophil-to-lymphocyte ratio in amyotrophic lateral sclerosis: a systematic review and meta-analysis.

Brain Commun. 2026;8(2):fcag132. Epub 2026 Apr 11
Authors: Eissazade N, Nazemi L, Haghi Ashtiani B, Moradi-Lakeh M
PubMed: 42051853
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Effect of traditional Chinese medicine non-pharmacological interventions on cognitive function in patients with mild cognitive impairment: a systematic review and network meta-analysis.

Front Med (Lausanne). 2026;13:1799759. Epub 2026 Apr 13
Authors: Dong Z, Li P, Xu J, Wang S, Li Z, Yang N, Zhang Z, Wu X
PubMed: 42051696
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Oropharyngeal dysphagia and amyloid beta pathology in the TgF344-AD rat model of Alzheimer's disease.

Front Behav Neurosci. 2026;20:1812480. Epub 2026 Apr 13
Authors: Cullins MJ, Converse AK, Rowe LM, Hoerst AG, Hibbard WK, Russell JA, Connor NP, Ciucci MR
PubMed: 42051629
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Interaction between Poly(ADP-ribose) polymerase-1 and α-synuclein pathology in Parkinson's disease.

Front Neurosci. 2026;20:1774158. Epub 2026 Apr 13
Authors: Zhang P, Li Q, Diao X, Zeng S
PubMed: 42051564
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APOE4 carriers resistant to cognitive decline show unique relationships between cerebrovascular response to exercise and dual-task cognitive-balance performance.

Front Neurosci. 2026;20:1716713. Epub 2026 Apr 13
Authors: Palmer JA, Billinger SA
PubMed: 42051551
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Gut microbiota and ALS: cause, consequence or correlation? - a systematic review.

Front Neurosci. 2026;20:1774417. Epub 2026 Apr 13
Authors: Chakraborty DK, Roy T, Ngo ST, Al-Chalabi A, Al Khleifat A
PubMed: 42051550
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Deciphering the peripheral immune landscape of Alzheimer's disease through integrated multi-omics research and cohort validation.

Front Immunol. 2026;17:1648591. Epub 2026 Apr 13
Authors: Lv S, Kuang JY, Wang TW, Zhang LP, Liu J, Wang WD, Yang MF, Ni QB, Sun BL, Sun JY
PubMed: 42051535
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Dietary restriction as a potential neuroprotective intervention: a narrative review of its impact on neuroinflammation across neurodegenerative diseases and other neurological disorders.

Front Nutr. 2026;13:1731416. Epub 2026 Apr 13
Authors: Liu B, Zhang Y, Deng W, Zhou YN, Cao Y, Xiong L, Shen R, Lee SM, Bian J, Bian Y
PubMed: 42051348
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Montreal Cognitive Assessment (MoCA) Scale: Strengths, Limitations, and Implication for Clinical Practice.

Iran J Psychiatry. 2026 Jan;21(1):140-150.
Authors: Hadinezhad P, Noroozian M
PubMed: 42051279
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Cell death detection in iPSC-derived cortical neurons as model of neurodegeneration.

Methods Cell Biol. 2026;206:217-233. Epub 2026 Mar 9
Authors: Colasuonno F, D'Eletto M, Bellanca V, Piacentini M, Di Sano F, Rossin F
PubMed: 42062001
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Interpretable multivariate survival models: Improving predictions for conversion from mild cognitive impairment to Alzheimer's disease via data fusion and machine learning.

PLoS One. 2026;21(4):e0321671. Epub 2026 Apr 30
Authors: Rosales-Gurmendi DS, Fumagal-González GA, Orozco J, Farber J, Treviño V, Martinez-Ledesma E, Martinez-Torteya A, Rosales-Gurmendi F, Tamez-Peña J, Alzheimer’s Disease Neuroimaging Initiative
PubMed: 42060649
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Application of Photostimulation Therapy in Cognitive Function of Alzheimer's Disease Patients: A Scoping Review.

Clin Interv Aging. 2026;21:600468. Epub 2026 Apr 24
Authors: Xu B, Wan H, Liu P, Zhao Z, Xie Y, Meng J, Qin Y
PubMed: 42058736
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Individualized phenotyping of functional amyotrophic lateral sclerosis pathology in sensorimotor cortex.

Brain Commun. 2026;8(2):fcag127. Epub 2026 Apr 9
Authors: Kalyani A, Northall A, Schreiber S, Brüggemann J, Vielhaber S, Al Dubai M, Bin Ramadan A, Mattern H, Speck O, Reichert C, Kuehn E
PubMed: 42058282
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Chronic rhinosinusitis and posterior cingulate hypoperfusion on SPECT in dementia diagnosis.

Front Neurol. 2026;17:1777862. Epub 2026 Apr 14
Authors: Kanazawa M, Hatakeyama M, Imamura T, Kobayashi T
PubMed: 42057932
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The Syn-Q study: detection of cutaneous phosphorylated alpha-synuclein in Parkinson's disease progression: a trial protocol.

Front Neurol. 2026;17:1823991. Epub 2026 Apr 14
Authors: Parent JH, Levine T, Freeman R, Gibbons CH
PubMed: 42057930
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Retrospective longitudinal analysis of blood microRNA-7-5p as a possible progression biomarker in people with Parkinson's disease.

Front Neurosci. 2026;20:1784013. Epub 2026 Apr 14
Authors: Zadegan SA, Hutchinson C, Onuigbo C, Martinez-Lemus JD, Talbot L, Metter EJ, Doursout MF, Tharp E, Suescun J, Shahnawaz M, Ellmore TM, Schiess M, Adams C
PubMed: 42057903
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Unveiling the Neuroprotective Role of Nutritional Supplements in Neurodegenerative Diseases.

Cent Nerv Syst Agents Med Chem. 2025 Dec 4; Epub 2025 Dec 4
Authors: Singh S
PubMed: 42051103
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