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The Alzheimer's Reading Room

noreply@blogger.com (Alzheimer's Reading Room) — Thu, 08 Nov 2018 15:04:00 +0000

The goal of the Alzheimer's Reading Room is to help everyone to better understand, cope, and communicate with a person living with dementia.

About the Alzheimer's Reading Room

We help Alzheimer’s patients to live a better life. We accomplish this by providing excellent advice and practical solutions to the problems that caregivers face each day. Our solutions work and have been tested over time by millions of caregivers.

The Alzheimer's Reading Room is the publisher of the highest quality expert information currently available for the Alzheimer's those seeking information on: Alzheimer's care, dementia care, memory care, and for caregivers and dementia professionals.

The goal of the Alzheimer's Reading Room is to Educate and Empower Alzheimer's caregivers, their families, and the entire Alzheimer's and dementia community worldwide.

The Award Winning Alzheimer’s Reading Room Knowledge Base is considered to be the highest quality, deepest collection, of information on Alzheimer’s and dementia in the world.

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Originally published in the Alzheimer's Reading Room

Researcher developing novel therapy for Alzheimer's disease

noreply@blogger.com (Alzheimer's Reading Room) — Sat, 24 Jun 2017 16:49:00 +0000

A University of Oklahoma researcher is developing a novel therapy for Alzheimer's disease using "biopharmaceutical proteases" to attack the toxic plaque that builds up in the brain of an Alzheimer's patient.

This is an approach that he predicts will be lower in cost and higher in effectiveness than current therapies.

OU researcher developing novel therapy for Alzheimer's disease

Peter J. Heinzelman recently received a $75,000 grant from the Oklahoma Center for the Advancement of Science and Technology to pursue this research, which includes the development of a library of biopharmaceutical proteases for public use.

Heinzelman's previous research led to the idea that proteases, or proteins that degrade other proteins, would be more effective as a therapy for Alzheimer's disease than existing approaches.

The brain is surrounded by a barrier of cells that allows glucose to pass through but is resistant to drug molecules and therapeutic proteins.

What is the Difference Between Alzheimer’s and Dementia

By virtue of a single protease molecule able to degrade thousands of the plaque molecules, these proteases should be capable of delivering a catalytic benefit even if only small amounts pass through the cell barrier surrounding the brain.

"Digestive enzymes are promiscuous," says Heinzelman. "We can create catalytic proteases that attack the beta-amyloid plaque that cause neurons in the brain to die. Current therapies use amyloid-binding antibodies that are created by the body or injected to get rid of the plaque, but these antibodies used to attack the problematic Abeta molecules can only bind one time and clear one Abeta molecule, then they are done."

The delivery system is problematic, too. Heinzelman suggests an approach that addresses both therapeutic efficacy and delivery.

He wants to re-engineer an existing technology to link proteases with "ferrying" antibodies that can encourage passage of the proteases from the circulation side across the brain cell barrier and into the brain tissue.

This approach has been demonstrated in the laboratory.

Test Your Memory for Alzheimer's (5 Best Tests)

Another aspect of the OCAST grant is the development of a library of proteases that will be made freely available and could become a powerful tool for the scientific community.

Heinzelman is working with researchers from the University of Wisconsin-Madison and the Oklahoma Medical Research Foundation on this grant.

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How to Change Patterns of Behavior in Dementia Patients

noreply@blogger.com (Alzheimer's Reading Room) — Wed, 21 Jun 2017 18:42:00 +0000

Patterns. All dementia patients evidence patterns of behavior.

Some of the patterns are simple -- like asking over and over what day it is. Others are more complex. One reader told us her husband was shaving four times a day and his face was getting "raw". Others pace. The list goes on and on.

My mother was evidencing all kinds of patterns of behavior -- doing the same crazy things at the same time of day or night -- over and over.

Listen Here or Read the Article in The Alzheimer's Reading Room

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Contrary to what some people may think, dementia is not a less severe problem, with Alzheimer's disease being a more severe problem.

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Getting a person living with Alzheimer's or dementia to take a shower or bath is one of the most common problems we face as caregivers.

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I Think About Alzheimer's Caregivers Everyday - Caregiving

noreply@blogger.com (Alzheimer's Reading Room) — Tue, 07 Mar 2017 17:29:00 +0000

Read Article or Listen Now

I know what caregiving feels like. I took care of my mom, Dotty, for eight and a half years, 3,112 days.

Listen Now

*Read the article and get links to more information for caregivers.*

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FSU research links brain shape to personality differences

noreply@blogger.com (Alzheimer's Reading Room) — Fri, 27 Jan 2017 19:39:00 +0000

New research reveals the shape of our brain can provide surprising clues about how we behave and our risk of developing mental health disorders.

The traits include:

neuroticism, the tendency to be in a negative emotional state;

extraversion, the tendency to be sociable and enthusiastic;

openness, how open-minded a person is; agreeableness, a measure of altruism and cooperativeness; and conscientiousness, a measure of self-control and determination.

FSU research links brain shape to personality differences

*** Neuroticism is a long-term tendency to be in a negative emotional state. People with neuroticism tend to have more depressed moods - they suffer from feelings of guilt, envy, anger, and anxiety more frequently and more severely than other individuals. Neuroticism is the state of being neurotic.

*** Extraversion is one of the five personality traits of the Big Five personality theory. It indicates how outgoing and social a person is. A person who scores high in extraversion on a personality test is the life of the party. They enjoy being with people, participating in social gatherings, and are full of energy.

*** An open-minded person is willing to try new things or to hear and consider new ideas.

Why Do People Living with Alzheimer's Want to Go Home?

noreply@blogger.com (Alzheimer's Reading Room) — Tue, 24 Jan 2017 15:55:00 +0000

Do Alzheimer's patients want to go home? Or are they longing for a time and place when they were safe and secure and knew everyone's name and face?

Why Do People Living with Alzheimer's Want to Go Home?

I gave up my career to care for my grandmother who has Alzheimer’s

noreply@blogger.com (Alzheimer's Reading Room) — Thu, 12 Jun 2014 15:20:00 +0000

When her grandmother developed dementia, Sophie Howarth, 26, quit her job and moved in as her carer – it was the best decision she ever made.

Of all the things you expect to be doing when you’re a 23-year-old graduate with a great job (and even better prospects), giving it all up to move in with your gran to care for her full time isn’t one of them.

Learn More - How to Understand the Difference Between Dementia and Alzheimer's Disease

Especially if your 85-year-old gran has severe dementia.

But that’s what happened to me and what an eye-opener it has been, profoundly changing my personality, my career path and my whole attitude to life.

Dementia is relentless, depressing and debilitating. And that’s just for the carer.

There were days, in the months after I’d moved from a busy London life to be with my gran in Hadfield, a small Derbyshire village, that I wondered if I, myself, had done the right thing.

I was very low. Gran would ask the same question again and again and again.

If I dared have a quick shower, I would often get the inevitable phone call. ‘Your gran’s outside the post office in her nightie, love’.

This was a job harder than any employer could have thrown at me and it was 24/7, with a care allowance income of just £53 a week.

Continue reading at the Mirror

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New Lord Mayor wants dementia friendly streets

noreply@blogger.com (Alzheimer's Reading Room) — Thu, 12 Jun 2014 15:18:00 +0000

New Lord Mayor wants dementia friendly streets

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Steroids Prescribed in the ICU Linked to Delirium

noreply@blogger.com (Alzheimer's Reading Room) — Tue, 27 May 2014 20:05:00 +0000

Overall, up to 80 percent of ventilated patients develop delirium in the ICU, and researchers have been looking for risk factors.

New Johns Hopkins research suggests that critically ill patients receiving steroids in a hospital’s intensive care unit (ICU) are significantly more likely to develop delirium

Results of their research, they say, suggest minimizing the use of steroids could reduce delirium in the ICU.

Steroids Prescribed in the ICU Linked to Delirium

While it usually goes away after a few days, studies show delirium in the ICU has a long-term impact. It has been associated with worse functional recovery and cognitive impairments of a magnitude consistent with moderate traumatic brain injury or mild Alzheimer’s disease.

Overall, up to 80 percent of ventilated patients develop delirium in the ICU, and researchers have been looking for risk factors.

In a report published in the June issue of the journal Critical Care Medicine, the investigators said that in more than one-third of the ICU days evaluated, mechanically ventilated patients with acute lung injury were given systemic corticosteroids at a range of doses during their ICU stay.

For the study, researchers looked at the medical records of 330 acute lung injury patients with a collective 2,286 days in an ICU at four Baltimore hospitals between October 2004 and October 2007.
They found that patients were 52 percent more likely to newly develop delirium if they had been treated with steroids on the prior day.
Older age was also associated with an increased risk of developing delirium. Delirium can be marked by poor memory and thinking, sometimes with disorientation, hallucinations and agitation.

“We need to be cautious in our use of steroids in critically ill patients and weigh the risks and benefits of using them,” says study leader Dale M. Needham, M.D., Ph.D., an associate professor of medicine and of physical medicine and rehabilitation at the Johns Hopkins University School of Medicine. “Sometimes they are necessary, but we need to be thoughtful about minimizing the dose and duration of steroid use when possible.”

Needham says there are a wide variety of reasons why an ICU patient would receive steroids. They may be ordered to respond to inflammation in the lung or elsewhere in the body.

Steroids also were used frequently to treat septic shock in the ICU, but more recent studies have shown fewer benefits from steroids in this condition.

Other research being done by Needham and his group suggests that steroids may also have an effect on patients’ physical impairments after they leave the ICU.
Along with Needham, other Johns Hopkins researchers involved in the study include Elizabeth Colantuoni, Ph.D.; Oscar J. Bienvenu, M.D., Ph.D.; Karin J. Neufeld, M.D., M.P.H.; and Pedro A. Mendez-Tellez, M.D. Researchers from the University of Maryland School of Medicine, University of Nevada School of Medicine and Chang Gung University in Taiwan also contributed.
The research was supported in part by a grant from the National Institutes of Health’s National Heart, Lung and Blood Institute (P050 HL73994).

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Playing an Alzheimer's Sufferer Changed His Understanding of the Disease

noreply@blogger.com (Alzheimer's Reading Room) — Mon, 19 May 2014 13:04:00 +0000

"We have a fear of losing our minds, and I'm as bad as anyone else... But when you're going to commit yourself to making a film about the subject, you feel like you have a responsibility to know all you can about the subject," he said.

Ray Winstone has revealed how playing someone with Alzheimer's Disease has given him a new understanding of the condition, as Dementia Week launched.

Read the article.

Ray Winstone says playing a Alzheimer's sufferer changed his understanding of the disease

Bob DeMarco
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Walk, fest, music for Alzheimer’s awareness

noreply@blogger.com (Alzheimer's Reading Room) — Sun, 18 May 2014 12:10:00 +0000

For the first time, this Memorial Day the Alzheimer’s Awareness Group for Kids will have its own float and walkers in the Memorial Day parade.

Walk, fest, music for Alzheimer's awareness http://t.co/lN3NJzxpZQ #alzheimers #health — AlzheimersRead (@ALZHEIMERSread) May 18, 2014

Bob De Marco
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Dementia patients are being sent from hospital to homes without heating or food

noreply@blogger.com (Alzheimer's Reading Room) — Wed, 07 May 2014 15:48:00 +0000

Dementia sufferers are being sent from hospital to homes without heating or food.

A health watchdog has warned as it announces the first national inquiry into the way patients are discharged from wards.

Read the entire article written by Laura Donnelly in the Telegraph.

Hospitals send dementia patients to homes without food or heating

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why not try a free subscription to the Alzheimer's Reading Room email.

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Alzheimer's Reading Room

When is dementia not dementia?

noreply@blogger.com (Alzheimer's Reading Room) — Mon, 05 May 2014 13:28:00 +0000

Cognitive tests to help doctors diagnose the disease are claimed to be unreliable

Further to recent complaints by visitors to doctors’ surgeries that they are needlessly being ambushed with cognitive tests so that practitioners meet targets for dementia diagnoses, comes the claim that the tests themselves are unreliable.

“Most patients referred with a diagnosis of possible dementia don’t have it,” observes neurologist Dr Jan Coebergh, writing in the British Medical Journal.

Continue reading in The Telegraph

Doctor's Diary: When is dementia not dementia?

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Bing Search - Killing neurons in the brain Alzheimer's disease

noreply@blogger.com (Alzheimer's Reading Room) — Wed, 30 Apr 2014 19:50:00 +0000

Exactly how Alzheimer's disease kills brain cells is still somewhat of a mystery, but University of Michigan researchers have uncovered a clue that supports the idea that small proteins prick holes into neurons.

A reader searching Bing using the following keywords was referred to this article in the Alzheimer's Reading Room.

Killing neurons in the brain Alzheimers disease

How Alzheimer's Disease Kills Brain Cells

“The better the research community understands how Alzheimer's operates, the more likely we are to develop an effective treatment.”

~ Michael Mayer

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The Alzheimer Society of Ireland - Volunteers needed for a new study that focuses on dementia care

noreply@blogger.com (Alzheimer's Reading Room) — Mon, 28 Apr 2014 12:17:00 +0000

De-Stress is a new three year study that will provide, for the first time in Ireland, information on the determinants of the health of spousal dementia caregivers.

The study is being carried out by researchers in Trinity College Dublin’s NEIL (NeuroEnhacement for Independent Lives) programme and is funded by The Alzheimer Society of Ireland and the Health Research Board.

Volunteers needed for a new study that focuses on the health and well-being of spousal dementia care

To learn more about Alzheimer's and Dementia care visit the Alzheimer's Reading Room

Art provides healing for Alzheimer's patients

noreply@blogger.com (Alzheimer's Reading Room) — Thu, 24 Apr 2014 12:07:00 +0000

For David, a resident at the Arbors of Bedford, the poem "The Sugar Maple Tree," by Diann Sheldon, inspired him to express himself through his painting "Embracing Branches."

Art provides healing for Alzheimer's patients in Bedford

To learn more about Alzheimer's and Dementia care visit the Alzheimer's Reading Room

How Sundowning affects me

noreply@blogger.com (Alzheimer's Reading Room) — Sun, 30 Mar 2014 18:20:00 +0000

Barry could you explain how you feel whilst Sundowning, does anything trigger it or does it just happen like clockwork?

The easy answer would have been to just to say yes (It happens like clockwork) but I think the subject is far more complex than that as it seems that Sundowning as it’s called can affect people with our illness at different times of the day, “in fact” a similar thing can also happen at the beginning of the day when the sun is rising, although the latter part of the day when the sun is setting seems to be the most significant time...

Continue Reading

How Sundowning affects me

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BLONDES VS. BRUNETTES LUBBOCK, TX

noreply@blogger.com (Alzheimer's Reading Room) — Thu, 27 Mar 2014 17:26:00 +0000

The funds raised through BvB benefit the care, support and research efforts of

the Alzheimer’s Association.

2014 BLONDES VS. BRUNETTES
LUBBOCK, TX

MORE INFORMATION

So far the Blondes have outraised the Brunettes by a 2 to 1 ratio.

TOP FUNDRAISERS
1 - Gridiron Self Donation Becky Fortenberry ($250.00)
2 - Gridiron Self Donation Heather Haynes ($250.00)
3 - First Down Self Donation Sarah Doerr ($135.00)
4 - First Down Self Donation Alexandra Galle ($125.00)
5 - First Down Kyriea Kana ($120.00)

To learn more about Alzheimer's and Dementia care visit the Alzheimer's Reading Room

Alzheimer's Patient Falls in Shower Forced to Wait 3 Hours Outside Hospital

noreply@blogger.com (Alzheimer's Reading Room) — Wed, 26 Mar 2014 16:35:00 +0000

Norma Leake called for an ambulance after her husband Raymond, who lives with Alzheimer's disease, fell in the shower and damaged his shoulder.

Raymond Leake, 82, who suffers from Alzheimer's, fell in the shower
Was left for three hours in the ambulance bay of University Hospital Wales
Mr Leake's family, from Penarth, were outraged after the incident
His son Andrew, 57, from Chester, called the incident 'unbelievable'
Hospital said their patient flow and emergency calls were unusually high

Read the complete story.

Family’s outrage after Alzheimer's sufferer, 82, forced to wait THREE hours outside hospital in ambulance

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Republican primary winner Atanus says dementia, autism caused by gays

noreply@blogger.com (Alzheimer's Reading Room) — Thu, 20 Mar 2014 12:40:00 +0000

SusanneAtanus said that God is punishing Americans for their support of marriage equality and women’s reproductive rights with scourges like dementia, autism, and severe weather.

Read more about this in the Wonkette.

Meet Your Newest GOP Congressional Nominee, Illinois: Wingnut Lady Who Says Gays Cause Autism, Dementia And Tornadoes

To learn more about Alzheimer's and Dementia care visit the Alzheimer's Reading Room

Google Keyword Search - free test for alzheimer's disease

noreply@blogger.com (Alzheimer's Reading Room) — Wed, 19 Mar 2014 13:49:00 +0000

A reader searching Google using the following keywords

free test for alzheimer's disease

clicked on the headline below to get the information they were seeking.

Test Your Memory for Alzheimer's (5 Best Memory Tests)

This is a list of the best free memory tests for Alzheimer's and dementia backed by reputable science. Alzheimers dementia tests online.

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The Eye May Provide a Window to the Brain and Early Onset Alzheimer's

noreply@blogger.com (Alzheimer's Reading Room) — Wed, 19 Mar 2014 12:33:00 +0000

By using the eye as a window to brain activity and function, we may be able to diagnose Alzheimer's and dementia patients sooner and give them more time to prepare for the future.

Alzheimer's Clips

Options may include earlier enrollment in clinical trials, developing support networks and dealing with any financial and legal matters.

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Variations in Eye Structure and Function May Reveal Features of Early-Stage Alzheimer’s Disease

Visual Disturbances May Be Seen in Alzheimer’s Disease Prior to Diagnosis

Investigators at the Cedars-Sinai Regenerative Medicine Institute have discovered eye abnormalities that may help reveal features of early-stage Alzheimer’s disease.

Using a novel laboratory rat model of Alzheimer’s disease and high-resolution imaging techniques, researchers correlated variations of the eye structure, to identify initial indicators of the disease.

Alzheimer’s disease is the leading cause of dementia, which is characterized by loss of memory and a progressive decline in cognitive function.

To date, more than 26 million people are estimated to suffer from the disease and the number is expected to quadruple by 2050. Despite the disease being described over a century ago, treatment and understanding of the disease remain rather limited.

“Detecting changes in the brain that indicate Alzheimer’s disease can be an extremely challenging task,” said Shaomei Wang, MD, PhD, lead author of the study and an associate professor in the Regenerative Medicine Institute and Department of Biomedical Sciences. “By using the eye as a window to brain activity and function, we may be able to diagnose patients sooner and give them more time to prepare for the future. Options may include earlier enrollment in clinical trials, developing support networks and dealing with any financial and legal matters.”

______________________________________

Using both animal models and postmortem human retinas from donors with Alzheimer’s disease, researchers found changes in the retinal pigment epithelial layer, which harbors the supportive cells located in the back of the eye, and in the thickness of the choroidal layer that has blood vessels providing nutrients to the retina. Changes in these two regions were detected using sophisticated, state-of-the-art imaging and immunological techniques.

With high-resolution, microscopic imaging and visual acuity measurements, investigators were able to monitor tissue degeneration in the cell layer and vascular layer at the back of the eye, as well as decline in visual function, that were strongly associated with Alzheimer's disease.

“Greater magnitude in these eye abnormalities may mean a greater chance of a patient having Alzheimer’s disease,” said Alexander Ljubimov, PhD, director of the Eye Program within the Regenerative Medicine Institute and co-author of the study. “We found that a rat model showed similar signs to the human ailment in the eye. If true in a larger number of humans, these findings may be used to study Alzheimer’s disease mechanisms and test potential drugs.”

Though additional research is needed to investigate the mechanisms of these ocular changes in relation to changes in the brain, investigators hope to ultimately aid early diagnosis of Alzheimer’s disease by studying the most approachable part of the central nervous system: the eye. Cedars-Sinai has been at the cutting edge of studies on the eye and Alzheimer’s disease with a previous report showing amyloid plaques, a hallmark of Alzheimer’s disease, also build up in the eye using a similar animal model of the disease.

“It is fascinating that the eye may provide such a window to the brain and eventually predict diseases such as Alzheimer’s, although more human studies are now needed to confirm this animal work,” said Clive Svendsen, PhD, director of the Cedars-Sinai Regenerative Medicine Institute and a co-author on the study.

Other members of the Regenerative Medicine Institute Eye Program, include Yu Chun Tsai, PhD, a post-doctoral fellow; and Bin Lu, MD, PhD, and Sergey Girman, PhD, both project scientists.

Additional investigators include Fred N. Ross-Cisneros and Alfredo A. Sadun, both from the University of Southern California Keck School of Medicine, and Robert M. Cohen from Emory University.

Citation: Investigative Ophthalmology & Visual Science. 2014 January: Ocular Changes in TgF344-AD Rat Model of Alzheimer’s disease.

To learn more about Alzheimer's and Dementia care visit the Alzheimer's Reading Room

Alzheimer's Disease Summit The Path to 2025

noreply@blogger.com (Alzheimer's Reading Room) — Tue, 18 Mar 2014 15:26:00 +0000

Over 35 million people worldwide are living with Alzheimer's disease (AD) or a related disorder, and this number is expected to exceed 115 million by 2050.

In 2010, the worldwide costs of AD and related disorders (ADRD) were estimated at $604 billion, or 1% of GDP, and these costs are expected to reach $950 billion by 2025. These disorders thus represent a public health and fiscal crisis that is straining governments across the world.

The U.S. National Alzheimer's Plan aims to achieve effective prevention and treatment of Alzheimer's disease by 2025.

On November 6–7, 2013, the New York Academy of Sciences convened stakeholders from industry, academia, and government, as well as from nonprofit, advocacy, financial, and philanthropic organizations, to develop a research agenda focused on the 2025 goal of the U.S. National Plan.

The Alzheimer's Disease Summit: The Path to 2025 conference explored how to accelerate the development of new diagnostics and therapeutics, coordinating with government efforts to build research resources, reengineer drug-development systems, and identify innovative technologies and financing mechanisms.

The conference was jointly presented by the Academy's Alzheimer's Disease and Dementia Initiative, the Global CEO Initiative on Alzheimer's Disease, and the National Institute on Aging, National Institutes of Health.

Alzheimer's Disease Summit

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Just a Word - Alzheimer's

noreply@blogger.com (Alzheimer's Reading Room) — Mon, 17 Mar 2014 14:04:00 +0000

Just a Word is a book about the crushing realization of what happens when someone you love is diagnosed with Alzheimer's disease.

Just a Word: Alzheimer's

The most fascinating aspect of this book is that it reads very fast; and if, you are an Alzheimer's Care Partner you might find your heart pounding during certain real life episodes during the book.

Written by Rose Lamatt, this is a real life story that includes many of Rose's secret thoughts as she travels along a 14 year journey with her friend Carol.

I like this book because it made me think. Think about what I might be facing in the years ahead as an Alzheimer's caregiver for my mother, Dotty.

I found myself wondering what I would do if I found myself in situations similar to what Rose was facing?

The book helped me to prepare for the likely future and to develop strategies I would use when the time came.

The book reads like a wonderfully written play with the obvious sad conclusion.

One thing for certain this book is a lot more than Just a Word.

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Man with Alzheimer's found living with dead wife, dead dog

noreply@blogger.com (Alzheimer's Reading Room) — Fri, 14 Mar 2014 15:49:00 +0000

Rhode Island authorities say a 71-year-old man living with Alzheimer's disease and dementia had lived with his dead wife's body for at least two days.

Police in Johnston say the man's 67-year-old wife died a few days ago and he wasn't aware that she had passed. Authorities say there were no signs of foul play.

Authorities say the man called the Fire Department on Wednesday and officials found the woman's body and a dead dog. The home was condemned because of what authorities called deplorable living conditions.

The man was taken to a hospital for an evaluation and officials were trying to contact his family. The medical examiner's office is investigating how the woman died.

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