Analytical Chemistry News

Going where the imagination goes

Thu, 09 Jul 2009 10:00:00 EDT

Creative thinking has guided Mitch Zakin’s career from conducting experiments at the dining room table to managing chemistry programs at the Defense Advanced Research Projects Agency.

Infochemistry: the new word on the block

Thu, 02 Jul 2009 10:00:00 EDT

Programs at the Defense Advanced Research Projects Agency harness the combined powers of chemistry and information technology.

New analysis seen as validating dinosaur proteomics study

Thu, 18 Jun 2009 10:00:00 EDT

John Asara, Mary Schweitzer, and colleagues follow up their controversial 2007 T. rex study with collagen sequenced from a different dinosaur.

FluidFM: atomic force microscopy meets nanofluidics

Thu, 11 Jun 2009 10:00:00 EDT

Hollow cantilevers dispense liquids to stimulate single live cells under physiological conditions.

Slipping on a chip

Thu, 11 Jun 2009 10:00:00 EDT

The SlipChip, a microfluidic device for multiplexed reactions, lacks pumps and valves, which makes for easy fabrication and operation.

Developing air-quality measurements for the world

Thu, 04 Jun 2009 10:00:00 EDT

An unexpected ozone reaction helps researchers devise a simple, inexpensive technique that could make air-quality measurements routine throughout the world.

Keepers Of The Gate

Thu, 04 Jun 2009 10:00:00 EDT

Advanced imaging and detection technologies help root out threats of terrorism in airports.

A Historic Commitment

Thu, 04 Jun 2009 10:00:00 EDT

The Editor describes listening to Barack Obama’s speech at the National Academy of Sciences and discusses the president’s vision for future scientific research.

CE of fungal conidia

Thu, 28 May 2009 10:00:00 EDT

Researchers optimize CE methods to identify strains of microscopic filamentous fungi.

Finding the fat

Thu, 28 May 2009 10:00:00 EDT

Compound Raman microscopy not only reveals images of lipid droplets inside living cells and animals quickly but allows researchers to analyze the droplets’ compositions.

Microfluidic NMR comes to a good resolution

Thu, 21 May 2009 10:00:00 EDT

Arno Kentgens talks with AC about his group’s new miniaturized NMR flow probe.

Hard−soft microfluidic device bypasses drawbacks of PDMS

Thu, 21 May 2009 10:00:00 EDT

Researchers optimize CE methods to identify strains of microscopic filamentous fungi.

NSF Rolls Out Stimulus Plan

Thu, 21 May 2009 10:00:00 EDT

Agency will use money to support mix of new and existing programs.

Quantum Dots That Don't Blink

Thu, 21 May 2009 10:00:00 EDT

Core structure suppresses blinking and leads to unusual spectral behavior

Reading the blueprint of life with scanning tunneling microscopy

Thu, 14 May 2009 10:00:00 EDT

A conversation with Stuart Lindsay of Arizona State University. Lindsay describes work where he and his colleagues use scanning tunneling microscopy to read out DNA bases.

The secrets caves keep

Thu, 14 May 2009 10:00:00 EDT

Monitoring peptide cleavage with a nanopore

Thu, 14 May 2009 10:00:00 EDT

Researchers use α-hemolysin to follow proteolytic reactions.

Electrokinetics: it’s in their genes

Thu, 07 May 2009 10:00:00 EDT

Researchers perform a comprehensive study paving the way for aptamer arrays

Fully Automated Analysis of β-Lactams in Bovine Milk by On-Line Solid Phase Extraction LC/ESI-MS/MS

Thu, 07 May 2009 10:00:00 EDT

Researchers perform a comprehensive study paving the way for aptamer arrays

Collisions or Electrons? Protein Sequence Analysis in the 21st Century

Thu, 07 May 2009 10:00:00 EDT

Researchers perform a comprehensive study paving the way for aptamer arrays

Cell typing by aptamers: a cautionary tale

Thu, 30 Apr 2009 10:00:00 EDT

Researchers perform a comprehensive study paving the way for aptamer arrays

MALDI MS of an LSPR sample

Thu, 30 Apr 2009 10:00:00 EDT

Researchers use an off-line combination of SPR and MS to analyze Alzheimer’s oligomers.

New Molecules In Space

Thu, 30 Apr 2009 10:00:00 EDT

Discovery of two complex compounds hints at more chemical diversity lurking in space

A marriage of convenience

Thu, 23 Apr 2009 10:00:00 EDT

Optoelectronic tweezers are combined with electrowetting-on-dieletric to manipulate particles inside moving droplets.

Microdroplets and MS: together at last

Thu, 23 Apr 2009 10:00:00 EDT

A new device couples MS to microdroplet microfluidics to provide label-free analysis.

LOT for brains

Thu, 23 Apr 2009 10:00:00 EDT

A lab-on-a-tube device is designed for implantation in patients with traumatic brain injuries.

Single-Molecule Fluorescence Events Seen In Real Time

Thu, 23 Apr 2009 10:00:00 EDT

Flashes of light help monitor electrocatalytic events that take place at discrete sites on the surface of single-walled carbon nanotubes

Improved Nanowire-Cell Connections

Thu, 23 Apr 2009 10:00:00 EDT

Versatile new design allows individual cells to be oriented over nanowire transistor arrays for better recording of the cells’ electrical activity

Stillness is golden

Thu, 16 Apr 2009 10:00:00 EDT

Researchers achieved unprecedented long-term stability of an atomic force microscope in air by using a laser stabilization technique.

Upcoming meetings

Thu, 16 Apr 2009 10:00:00 EDT

Two conferences highlight separations techniques.

Learning how the bonds break

Thu, 16 Apr 2009 10:00:00 EDT

Electron affinity tags provide insight on ECD/ETD mechanism.

A molecular force probe

Thu, 16 Apr 2009 10:00:00 EDT

Researchers design a series of strained molecules to study the kinetics of a molecular reaction.

A centuries-old love affair with hot chocolate

Thu, 9 Apr 2009 10:00:00 EDT

A conversation with W. Jeffrey Hurst at the Hershey Center for Health and Nutrition.

The shapes of little things

Thu, 9 Apr 2009 10:00:00 EDT

Researchers use centrifugation to separate nanorods from a mixture of particles.

CARS trumps spontaneous Raman scattering?

Thu, 9 Apr 2009 10:00:00 EDT

Signal strengths of the two methods may be comparable, despite assertions in the literature.

Nanospray current under control

Thu, 9 Apr 2009 10:00:00 EDT

Running at constant current improves nanospray performance.

April 1st Issue Podcast

Thu, 02 Apr 2009 10:00:00 EDT

Listen to Senior Associate Editor Rajendrani Mukhopadhyay discuss the cover article and other issue content.

Automated microfluidic phosphoprofiling

Thu, 02 Apr 2009 10:00:00 EDT

Researchers use a new chip platform to study phosphorylation in macrophage response.

Hurry for your chance at NIH and NSF stimulus funding

Thu, 02 Apr 2009 10:00:00 EDT

New funding opportunities exist as a result of the U.S. stimulus package.

Weathering The Crisis

Thu, 02 Apr 2009 10:00:00 EDT

Some instrument vendors skipped Pittcon 2009, but more than 19,000 attendees did not

Shining Light On Art

Thu, 02 Apr 2009 10:00:00 EDT

Conservators use intense light sources for everything from characterizing pigments to removing lichens

Food Analysis Gets A Boost

Thu, 02 Apr 2009 10:00:00 EDT

New methods offer simpler, faster, more convenient ways to characterize food

PALM reaches deep into 3D

Thu, 26 Mar 2009 10:00:00 EDT

Two groups demonstrate different approaches to imaging samples with a resolution of tens of nanometers in the z direction.

A temperature sensor for microfluidics

Thu, 26 Mar 2009 10:00:00 EDT

A fluorescent polydiacetylene polymer can be used to monitor temperature in microfluidic devices.

Chewing through a DNA sequence

Thu, 26 Mar 2009 10:00:00 EDT

Special protein nanopores can identify bases in a DNA strand continuously without any labels.

DNA aggregates detected as hot spots in electrofluorescence of SAMs

Thu, 26 Mar 2009 10:00:00 EDT

Sensor surfaces may not be as homogeneous as previously thought.

Two new methods for ricin detection

Thu, 26 Mar 2009 10:00:00 EDT

Making Diagnostics Affordable

Thu, 19 Mar 2009 10:00:00 EDT

Nonprofits and academics work toward tests that meet the needs of the developing world

Smooth or spiky? It’s in the fingertips

Thu, 12 Mar 2009 10:00:00 EDT

A biomimetic sensor reveals how fingertip ridges pick up information about fine textures on surfaces.

Key Advance In DNA Sequencing With Nanopores

Thu, 12 Mar 2009 10:00:00 EDT

High-quality detection takes the label-free, single-molecule technique closer to reality.

Seeing Proteins Inside Cells

Thu, 12 Mar 2009 10:00:00 EDT

For the first time, method yields a 3-D structure, reveals protein interactions in somatic cells.

ECD: not so random after all?

Thu, 12 Mar 2009 10:00:00 EDT

Electron capture dissociation ICR MS study of amphipathic peptides shows cleavage specificity.

Double duty: isodielectric technique simultaneously separates and characterizes particles

Thu, 05 Mar 2009 10:00:00 EDT

Researchers use a microfluidic device to analyze beads and cells with isodielectric separation.

Nanoparticles: An Emerged and Lasting Frontier

Thu, 05 Mar 2009 10:00:00 EDT

The Editor discusses the role that nanoparticles could play in measurement science.

DNA Sequencers: The Next Generation

Thu, 05 Mar 2009 10:00:00 EDT

The industry is striving to reach the frontier of affordable genomic sequencing.

Radiocarbon Dating of Ancient Rock Paintings

Thu, 05 Mar 2009 10:00:00 EDT

Radiocarbon dates have been taken on rock paintings that have no organic pigments. Marvin W. Rowe of Texas A&M University College Station and Qatar describes a technique in which argon and oxygen plasmas and accelerator MS are used to obtain radiocarbon dates on paintings with inorganic pigments.

New clues in contact lens solution fungal outbreak

Thu, 26 Feb 2009 10:00:00 EDT

A conversation with John Bullock at Wright State University. Bullock describes work that suggests improper storage of Bausch & Lomb’s ReNu with MoistureLoc may have caused a global fungal infection outbreak.

Pushing the limits of detection in capillary isoelectric focusing

Thu, 26 Feb 2009 10:00:00 EDT

Jennifer Griffiths reports from the 23rd International Symposium on MicroScale Bioseparations—Boston

Downsizing the optical trap

Thu, 26 Feb 2009 10:00:00 EDT

Nanoscale optical trap holds polystyrene particles and live bacteria for extended periods of time with moderate light intensities.

Imaging eukaryotic cells with liquid STEM

Thu, 26 Feb 2009 10:00:00 EDT

Liquid STEM allows direct imaging of fixed cells with nanometer resolution.

New members of the News and Features Advisory Panel

Thu, 26 Feb 2009 10:00:00 EDT

Seven researchers join Analytical Chemistry’s News and Features Advisory Panel.

Detecting hazardous chemicals from a distance

Thu, 19 Feb 2009 10:00:00 EDT

Thomas Thundat talks to AC about a new photoacoustic-spectroscopy-based technique developed by his group.

Predicting charges for ETD spectra

Thu, 19 Feb 2009 10:00:00 EDT

An interview with Paulo Carvalho at the Scripps Research Institute.

Measuring Cell Fever

Thu, 19 Feb 2009 10:00:00 EDT

Nanogel makes it possible to sense tiny temperature differences inside cells.

Learning how gold nanoparticles affect CE separations

Thu, 19 Feb 2009 10:00:00 EDT

Investigators study links between nanoparticle properties and analyte migration in CE.

A new method to analyze World Trade Center dust

Thu, 19 Feb 2009 10:00:00 EDT

Distinguishing dust produced by the disaster from background dust could help determine which areas of lower Manhattan need cleanup.

Magnetic resonance force microscope achieves nanoscale imaging

Thu, 12 Feb 2009 10:00:00 EDT

The combination of ultrasmall magnetic force measurements with 3D image reconstruction reveals biological structure on the low-nanometer scale

Hydrodynamic force microscopy goes with the flow

Thu, 12 Feb 2009 10:00:00 EDT

An extension of atomic force microscopy produces 3D profiles of gas microflows and maps substrate porosity on the nanoscale.

Optofluidics with subwavelength slot waveguides

Thu, 12 Feb 2009 10:00:00 EDT

Microfluidic device uses light to capture and transport particles.

Getting the inside story on a single cell

Thu, 12 Feb 2009 10:00:00 EDT

A new method allows unprecedented control of the intracellular environment.

Old plutonium, new tricks

Thu, 05 Feb 2009 10:00:00 EDT

Researchers coat coverslips with clay nanoparticles to create a new kind of electrode.

A Conversation with Some Postdoctorals

Thu, 05 Feb 2009 10:00:00 EDT

The Editor’s Q&A with some young researchers.

Clay nanoparticles for spectroelectrochemistry

Thu, 29 Jan 2009 10:00:00 EDT

Researchers coat coverslips with clay nanoparticles to create a new kind of electrode.

NMR’s got sole

Thu, 29 Jan 2009 10:00:00 EDT

Analysis of shoe soles dating from the 13th to 18th centuries sheds light on the archaeological preservation of leather.

Raman sensitivity takes a quantum leap

Thu, 29 Jan 2009 10:00:00 EDT

Unlabeled molecules become visible inside cells, thanks to stimulated Raman spectroscopy.

New methods detect radionuclide contamination

Thu, 22 Jan 2009 10:00:00 EDT

Jay Grate talks with AC about his two papers.

A new way to attract SERS analytes

Thu, 22 Jan 2009 10:00:00 EDT

Researchers use an electric field to draw molecules to SERS hot spots.

Equilibrium sampling with mussel

Thu, 22 Jan 2009 10:00:00 EDT

Lipid raft theory holds water

Thu, 22 Jan 2009 10:00:00 EDT

STED microscopy detects individual membrane lipids and shows that some may be part of complexes.

Corralling steroid-laced cattle

Thu, 15 Jan 2009 10:00:00 EDT

Using blood-chemistry analyzers more familiar in a human hospital setting, researchers are developing methods to identify illegal hormone doping in cattle.

Simulated spectra extend the lifetime of NIR calibrations

Thu, 15 Jan 2009 10:00:00 EDT

NIR multivariate calibration protocol can bypass the need to measure calibration samples.

Sticking it to microfluidics

Thu, 15 Jan 2009 10:00:00 EDT

A new method to transfer cells and tissues into microfluidic channels avoids the need for special culture conditions.

Up-conversion in vivo imaging

Thu, 15 Jan 2009 10:00:00 EDT

Researchers develop a small-animal up-conversion imager.

CE describes protein complexes

Thu, 08 Jan 2009 10:00:00 EDT

A novel application for an existing analytical technique provides structural information about protein–surfactant interactions.

Bring on the world to digital microfluidic devices!

Thu, 08 Jan 2009 10:00:00 EDT

A conversation with Aaron Wheeler at the University of Toronto.

PCR to go

Thu, 08 Jan 2009 10:00:00 EDT

Monitoring by magnetic levitation

Thu, 08 Jan 2009 10:00:00 EDT

Baring the bones of a medieval Moorish wall

Thu, 01 Jan 2009 10:00:00 EDT

Investigators discover minerals from powdered, burnt bones on a rampart in Granada, Spain.

Editorial Advisory Board

Thu, 01 Jan 2009 10:00:00 EDT

New Editorial Advisory Board members are profiled, and current members are listed.

2009 New Year’s Resolutions for Analytical Chemists

Thu, 01 Jan 2009 10:00:00 EDT

To analytical chemists of various stripes, the Editor offers potential resolutions.

Electrokinetic Detection and Characterization of Intact Microorganisms

Thu, 01 Jan 2009 10:00:00 EDT

A technique for the analysis of intact bacteria should be fast, highly efficient, broadly applicable, reproducible, qualitative, and quantitative. Ewa Kłodzińska and Bogusław Buszewski of Nicolaus Copernicus University (Poland) describe a number of useful achievements in separating and identifying bacteria by capillary zone electrophoresis and possible applications in medical diagnosis, consumer-products analysis, food contamination, and sterility testing.

Optical tweezers: not just for physicists anymore

Thu, 01 Jan 2009 10:00:00 EDT

A new generation of commercial instruments makes optical tweezers more accessible.

Spectroscopic detection of genetic alterations in “normal” cells

Thu, 25 Dec 2008 10:00:00 EDT

Partial wave spectroscopy reveals nanoscale changes before they appear in cell histology.