Big Pharma 411

Merck NEWS UPDATE

noreply@blogger.com (Adam Rubenstein - BOULDER, CO) — Tue, 30 Oct 2007 18:12:00 +0000

The National Institute of Allergy and Infectious Diseases (NIAID), part of the NIH, and the NIAID-funded HIV Vaccine Trials Network announced that vaccination in the STEP clinical trial of Merck's HIV vaccine candidate would be discontinued . The decision was based on recommendations made by an independent Data and Safety Monitoring Board for the STEP trial, which concluded that the vaccine could neither prevent HIV infection nor reduce the amount of virus in those who became infected with HIV.

Merck has been advised that the new drug application for over-the-counter MEVACOR (lovastatin) will be reviewed by the FDA Joint Meeting of the Nonprescription Drugs Advisory Committee and the Endocrinologic and Metabolic Drugs Advisory Committee on December 13, 2007. Merck is seeking approval of OTC MEVACOR (lovastatin) 20 mg taken once daily to help lower cholesterol, which may prevent a first heart attack.

In Phase IIb study results anacetrapib (formerly known as MK-0859), its investigational selective cholesteryl ester transfer protein inhibitor, significantly reduced LDL-cholesterol and Apolipoprotein B and increased HDL-cholesterol and Apolipoprotein A-1 both as monotherapy and in combination with atorvastatin 20 mg compared to placebo in patients with dyslipidemia.

CANCIDAS® (caspofungin acetate), given once daily, was evaluated as a treatment for patients three months to 17 years of age with documented or suspected fungal infections. The use of CANCIDAS in pediatric patients is investigational. Interim results from the first Phase II clinical trial to study this therapy in pediatric patients with invasive candidiasis, esophageal candidiasis or invasive aspergillosis (as salvage therapy only) will be presented.

Abbott Laboratories OVERVIEW SUMMARY

noreply@blogger.com (Adam Rubenstein - BOULDER, CO) — Thu, 18 Oct 2007 23:10:00 +0000

Abbott Laboratories (NYSE: ABT) operates in four segments: pharmaceutical products, diagnostic products, nutritional products, and vascular products.

The Pharmaceutical Products segment offers adult and pediatric pharmaceuticals for the treatment of dyslipidemia, cholesterol, rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, hypothyroidism, obesity, HIV infection, epilepsy and bipolar disorder, migraines, hyperparathyroidism, endometriosis and central precocious puberty, anemia, duodenal ulcers, gastric ulcers, erosive esophagitis, and hypertension.

The Diagnostic Products segment provides diagnostic systems and tests for blood banks, hospitals, commercial laboratories, physician's offices, alternate-care testing sites, plasma protein therapeutic companies, and consumers. Products include immunoassay systems, chemistry systems, assays for screening and diagnosis for drugs of abuse, cancer, therapeutic drug monitoring, fertility, physiological diseases, and infectious diseases, such as hepatitis and HIV, genomic-based tests, hematology systems and reagents, blood glucose monitoring meters, test strips, data management software, and accessories for people with diabetes, and point-of-care diagnostic systems and tests for blood analysis.

The Nutritional Products segment offers pediatric and adult nutritionals.

The Vascular Products segment provides a line of coronary, endovascular, and vessel closure devices for the treatment of vascular diseases.

Some deals and collaborations include:

A 50% owned joint venture with TAP Pharmaceuticals
A strategic alliance with Celera Diagnostics
A collaboration with Genentech (NYSE: DNA) to develop anti-cancer compounds

Merck NEWS

noreply@blogger.com (Adam Rubenstein - BOULDER, CO) — Tue, 16 Oct 2007 04:40:00 +0000

Genzyme (NASDAQ: GENZ) reported a Phase II trial of its leukemia drug Campath (monoclonal antibody targeting CD52) showed superiority at treating multiple sclerosis over Merck’s (NYSE: MRK) Rebif (Interferon beta-1a).

Merck FDA APPROVAL

noreply@blogger.com (Adam Rubenstein - BOULDER, CO) — Tue, 16 Oct 2007 04:37:00 +0000

The FDA granted Merck's (NYSE: MRK) Isentress™ (raltegravir) accelerated approval for use in combination with other antiretroviral agents for the treatment of HIV-1 infection in treatment-experienced adult patients who have evidence of viral replication and HIV-1 strains resistant to multiple antiretroviral agents. It is the first in a new class of drugs, which work to prevent HIV from inserting its DNA into human DNA, thereby inhibiting its ability to replicate and infect new cells. Merck has set the price for its newly approved AIDS drug Isentress at $27 a day wholesale, in the range of other popular medicines but lower than some at the highest end.

AstraZeneca NEWS

noreply@blogger.com (Adam Rubenstein - BOULDER, CO) — Tue, 16 Oct 2007 04:07:00 +0000

MedImmune an AstraZeneca (NYSE: AZN) subsidiary has licensed from Crucell (NASDAQ: CRXL) biologicals focused on hospital acquired bacterial infections. Note to Self: look at Methicillin-resistant Staphylococcus aureus market

Merck PRODUCTS Part II

noreply@blogger.com (Adam Rubenstein - BOULDER, CO) — Tue, 16 Oct 2007 03:21:00 +0000

Note to self: A look at AZ's products and pipline:

Vaccine products include:

Varivax to prevent chickenpox

MMRII for the treatment of measles, mumps, and rubella

ProQuad to prevent measles, mumps, rubella, and varicella

Gardasil to prevent cervical cancer and genital warts

Pneumovax to prevent pneumococcal diseases

RotaTeq to prevent rotavirus gastroenteritis

Zostavax to prevent of shingles UNIVERSITY COLORADO IP

Merck PRODUCTS Part I

noreply@blogger.com (Adam Rubenstein - BOULDER, CO) — Tue, 16 Oct 2007 03:10:00 +0000

Note to self: A look at AZ's products and pipline:

Therapeutic products include:

Singulair for chronic asthma, and allergic rhinitis

Cozaar and Vasotec for hypertension and heart failure

Fosamax for osteoporosis

Zocor for atherosclerosis

Primaxin & Cancidas anti-bacterial/anti-fungal products

Cosopt and Trusopt ophthalmological products

Proscar for benign prostate enlargement

Maxalt for acute migraines

Propecia for male pattern hair loss

Merck OVERVIEW SUMMARY

noreply@blogger.com (Adam Rubenstein - BOULDER, CO) — Tue, 16 Oct 2007 03:03:00 +0000

Merck (NYSE: MRK) headquartered in Whitehouse Station, NJ works in in both human and animal health (Merial).

Merck has agreements with:

Neuromed Pharmaceuticals for treatment of pain and neuro disorders

NicOx for the development of antihypertensive drugs

FoxHollow Technologies for atherosclerotic plaque analysis

Ariad Pharmaceuticals for AP23573, an mTOR inhibitor

AstraZeneca PIPELINE Part II

noreply@blogger.com (Adam Rubenstein - BOULDER, CO) — Sun, 14 Oct 2007 17:15:00 +0000

Note to self: A look at AZ's products and pipline:

AZD0530 Phase II for chemotherapy in patients with solid tumours

AZD1152 Phase II for Patients with advanced solid malignancies

AZD2171 (Recentin™) Phase III for non-small cell lung cancer or head and neck cancer

AZD2281 Phase II for advanced BRCA1 or BRCA2-associated ovarian cancer

AZD3480 Phase II for alzheimer's and schizophrenia

AZD4877 Phase II for recurrent or refractory (AML) excluding promyelocytic leukemia.

AZD6140 Phase III for non-ST or ST elevation acute coronary syndromes

AZD6244 Phase II for unresectable AJCC stage 3 or 4 malignant melanoma

AZD6765 Phase II for treatment-resistant major depressive disorders

AZD7762 Phase I for advanced solid malignancies

AZD8330 Phase I for advanced malignancies

AZD9056 Phase II for rheumatoid arthritis

ZD4054 Phase II for metastatic prostate cancer

ZD6474 ZACTIMA™ Phase II for metastatic breast cancer

AstraZeneca PIPELINE Part I

noreply@blogger.com (Adam Rubenstein - BOULDER, CO) — Sun, 14 Oct 2007 17:04:00 +0000

Note to self: A look at AZ's products and pipline:

Accolate™ (zafirlukast) Accolate™ (zafirlukast) an oral leukotriene receptor antagonist for the treatment of asthma

Arimidex™ (anastrozole) an aromatase inhibitor for use in postmenopausal women with hormone-sensitive early or advanced breast cancer.

Atacand™ (candesartan cilexetil) Phase III for diabetic retinopathy

Casodex™ (bicalutamide) an oral non-steroidal anti-androgen for prostate cancer

Crestor™ (rosuvastatin) Phase III for primary hypercholesterolaemia non-diabetic, non-atherosclerotic, metabolic syndrome patients with raised LDL-C

Entocort™ (budesonide) a glucocorticosteroid for inflammatory bowel diseases, Crohn's disease, and topical treatment of ulcerative colitis.

Faslodex™ (fulvestrant) is a hormonal treatment for hormone receptor-positive metastatic breast cancer in postmenopausal women whose disease has returned or progressed following antiestrogen therapy.

Iressa™ (gefitinib) an orally active EGFR tyrosine kinase inhibitor. It is currently available for the treatment of advanced non-small cell lung cancer (NSCLC)

Losec™ (omeprazole) and Nexium™ (esomeprazole) are acid pump inhibitors (also known as a proton pump inhibitor) for acid reflux syndrome.

Merrem™ (meropenem) is an ultra-broad spectrum injectable antibiotic for a wide variety of serious infections, including meningitis and pneumonia.

Oxis™ (formoterol) is a beta 2-agonist for asthma.

Seroquel™ (quetiapine) for schizophrenia and bipolar mania.

Zoladex™ (goserelin acetate) a luteinising hormone-releasing hormone analogue used to treat hormone-sensitive cancers of the prostate and breast (in pre-/perimenopausal women) and some benign gynaecological disorders (endometriosis, uterine fibroids and endometrial thinning).

Zomig™ (zolmitriptan) an oral, selective 5-hydroxytryptamine receptor agonist or 'triptan' for acute treatment of migraine attacks

AstraZeneca OVERVIEW SUMMARY

noreply@blogger.com (Adam Rubenstein - BOULDER, CO) — Thu, 11 Oct 2007 18:18:00 +0000

AstraZeneca (NYSE: AZN) headquartered in London works in the areas of cardiovascular, gastrointestinal, neuroscience, oncology, respiratory inflammation, and anti-infectives.

Products include:

Arimidex for hormonal breast cancer
Crestor for cholesterol levels
Nexium for acid-related diseases
Seroquel for schizophrenia and bipolar mania
Symbicort for asthma

Other areas of foci include medical devices and implants for use in urology, surgery, and odontology. In addition, Astrazeneca develops and manages out-patient cancer centers in the US.

Some strategic alliances include:

Some collaborators include:

Big Pharma 411 Off to the Races!

noreply@blogger.com (Adam Rubenstein - BOULDER, CO) — Thu, 11 Oct 2007 17:02:00 +0000

QUESTION:

What do J&J (NYSE: JNJ), Pfizer (NYSE: PFE), GlaxoSmithKline (NYSE: GSK), Novartis (NYSE: NVS), Sanofi-Aventis (NYSE: SNY), Merck (NYSE: MRK), Abbott Labs (NYSE: ABT), AstraZeneca (NYSE: AZN), Eli Lilly (NYSE: LLY) and Wyeth (NYSE: WYE) have in common?

ANSWER:

They are the ten biggest of big pharma with a combined market cap of approximately 1.17 trillion, with a capital T, dollars!

So as I have stated in the description box, this blog has been architected for selfish purposes. That is, I do a lot of work in the early-stage biotech realm, and you can keep up with that portion of my life here at Colorado Life Science Deal Flow however, my knowledge-base of which big pharma is leader in what particular drug class(es) and technology(ies) is deficient and thus I intend to address that deficiency here by:

Breaking down each entity by products and pipeline, and
Then keep up with news and milestones

I will maintain all of my notes here and plan to create a smart indexing process that will allow me, and obviously anyone else who finds their way here, to search this aggregated content by Company, by Indication and by Technology. Feel free to pepper me with your big pharma of choice for inclusion here. Naturally, I welcome any and all suggestions. And here we go…