#24 Genetic Testing on The John and Ken Show (May 5, 2008)
#23 Just Downloaded a File Containing my Raw Genome Data. Now What? (May 4, 2008)
#22 Visualization of My Genetic Similarity to People Around the World (Apr 30, 2008)
#21 How Heart Attack and Other Four Star-Rated Topics Relate to My DNA, Part 2 (Apr 24, 2008)
#20 Fun with Y Chromosomes: Exploring my Paternal Ancestry (Apr 16, 2008)
#19 Look Ma, I’m in Newsweek (Apr 14, 2008)
#18 Fun with mtDNA: Exploring my Maternal Ancestry (Apr 12, 2008)
#17 How Breast Cancer and Other Four Star-Rated Topics Relate to My DNA, Part 1 (Apr 11, 2008)
#16 Sharing My DNA Results (Apr 9, 2008)
#15 The Most Common Cancer (For Men) and Me (Apr 6, 2008)
#14 I Just Received an Exciting Email! (Apr 4, 2008)
#13 Bummer… I’m One of Those Customers (Apr 1, 2008)
#12 Still Waiting For My DNA Results (Mar 16, 2008)
#11 Demo 23andMe with the “Mendel Family” (Feb 23, 2008)
#10 We Joined The DNA Network plus Exciting Spit Challenge News (Feb 12, 2008)
#9 Spit Party Photos (Feb 10, 2008)
#8 Spit Challenge: Fill Tube With 2.5ml of Saliva in Under 146sec (Feb 7, 2008)
#7 FedEx Tracking Says DNA Kit Arrives Today (Feb 6, 2008)
#6 Saliva-Spitting 23andMe Party on Wednesday! (Feb 4, 2008)
#5 $1000 Raised! Just Ordered My 23andMe DNA Kit (Jan 22, 2008)
#4 Decoding My DNA Soon, $820 Raised So Far (Update: $1000 raised!) (Jan 11, 2008)
#3 Calling All 23andMe Saliva Spitting Bloggers! (Dec 16, 2007)
#2 Fundraising Updates for Andrew’s DNA Test (Dec 12, 2007)
#1 Help Me Decode My Genome by Christmas (Dec 6, 2007)

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Note: I tried to figure out a way to incorporate "100,000 watt blowtorch lighting the LA afternoon skies" into the above paragraph but gave up.

They invited Trish Brown, a VP at DNA Direct, and myself to talk during the segment. I guess someone over at The John and Ken Show found my blog while doing some random Googling.

During the interview, John & Ken were surprisingly quieter and less angry than I thought they were going to be. They asked me basic questions regarding the DNA test I chose, my test results and raising donations on my blog for the DNA test.

You can listen to the genetic testing segment on the podcast below. The genetic testing segment starts at 33:40min and goes to 59:40min (They talk to me at the 45:30min mark):

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23andMe lets you download a zipped, text file containing 500,000+ lines of your genotype call data. It's all the raw, uninterpreted data they pull from your saliva.

All. on. one. 5mb. zipped. file. And, about 14.2mb unzipped.

Why did I download the raw data file instead of keeping it protected behind the layers of encryption over on the 23andMe servers?

No particular reason. Just curious to see what a file containing 500,000+ lines of my genotype call data looks like.

Here's what it looked like when I opened it in TextEdit (Note: This is just the first 7 of 500,000+ lines):

I'll probably use the Promethease tool the guys over at SNPedia built as soon as they create a Mac version.

Does anyone know anything else I can do with my downloaded text file containing 500,000+ lines of my genotype call data?

I'm up for interesting suggestions.

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As you can see, I'm most similar to people from Northern Europe in the 23andMe visualization.

Here is how my genetic similarity to different global regions stacks up:

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They provide their own 1-4 star rating beside each Gene Journal topic letting users know how much research backs each specific topic and how much the general scientific community has accepted the research.

For instance, Heart Attack has a rating.

Whereas other topics might have a , or ratings.

23andMe provides a more detailed rating explanation:

Before I look at my Gene Journal topics D-H, I should note that 23andMe makes it very clear that their service is "Intended for research and educational purposes. Not for diagnostic use".

I'm pretty sure most of us who signed-up with 23andMe understood this fully before we shelled out $1000. But, we are curious consumers and enjoy the chance to learn a little more about ourselves no matter how young and immature the personal genomics space is.

Ok, let's look at four star-rated topics D-H in my Gene Journal (Check out Part 1 for topics A-C).

Earwax Type

Is wet earwax sexier than dry earwax (I have wet earwax)? Is earwax sexy at all?

After reading a little bit about the benefits of earwax I'm starting to see it through a more sexy tint. Why? Because stopping dust and shampoo from entering my inner ear is sexy.

Also, earwax might contain natural antibiotics to keep bacterial pirates from pillaging! Awesome. Earwax is getting sexier by the minute.

Eye Color

My eye color has been referred to as "Hazel" throughout my life, which is a variation of brown. I guess my eyes can't decide if they want to scatter or absorb light.

HIV/AIDS Infection

I really enjoy all the extra warnings and cautions attached to this one.

Pre-HIV this isn't very relevant. I don't see anyone changing their behavior based on which of the genotypes they have above. Post-HIV, I guess it might give you some sort of optimism to have Genotype DD rather than my II.

Heart Attack

Lifestyle, lifestyle, lifestyle.

You find Part 1 with topics A-C here. And, you can find more of my 'My Genome' posts here.

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If you want to get more specific, it looks like I'm part of the R1b1c9a branch.

23andMe says,

"Today R1b1c9a is found mostly on the fringes of the North Sea in England, Germany and the Netherlands, where it reaches levels of one-third. That distribution suggests that some of the first men to bear the haplogroup in their Y-chromosomes were residents of Doggerland, a real-life Atlantis that was swallowed up by rising seas in the millennia following the Ice Age."

Whoa. Doggerland? A real-life Atlantis? I got to look that up on Wikipedia.

I guess this doesn't sound too crazy since the only thing I remember from when my dad did the National Geographic Genographic Project was that at one time my paternal ancestors were Dutch Vikings.

I really hope this Doggerland myth isn't a myth since it sounds so cool. I'm going to try and not be too skeptical.

The map below shows where concentrations of R1b1c might have been located 500 years ago (Darker color equals more concentration).

Here is some of the R1bc1 story (I edited it down to the Introduction and R1bc19a part):

And, of course, famous people in my paternal haplogroup:

You can see my maternal ancestry post here. And, if you want me to share my 23andMe genetic profile with you than go here.

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The one with this cover (April 21, 2008 Issue):

Claudia Kalb did a great write-up of all the new-fangled personal genome services that have been popping up lately, like deCODEme, Navigenics and 23andMe (that's the one I did), and how they're being marketed.

The article is titled "May We Scan Your Genome?"

You can find the article on p.44 in the magazine and you can also read the full article on the Newsweek site here. The blurb from my interview is at the end of the article.

Update: View actual scans of the magazine article here.

Thanks to Hsien over at Eye on DNA for setting this up. She emailed me while I was driving, I answered back and like 5 minutes later Claudia Kalb called.

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Don't worry, I put this in the 'Disgusting Self-Promotion' category, too.

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My mtDNA determines that I belong to the PreHV maternal haplogroup (It sounds so all-encompassing, right?).

More specifically, I guess I'm part of daughter branches H and V, which are both most commonly found in Europe.

The map below shows where concentrations of PreHV might have been located 500 years ago (Darker color equals more concentration).

Supposedly, the PreHV haplogroup originated in Arabia and than spread to the Near East and than to Europe, Asia and northern Africa.

23andMe provides a fun little tool to explore "the tree of all maternal haplogroups".

It lets you expand and collapse subgroups, find your own haplogroup and the haplogroups of friends and family that you're sharing your genome with.

Oh yeah, how could any 23andMe blog post or article be complete without letting you know what famous people are in my haplogroup.

I think they need to add some more famous people to the PreHV haplogroup database, because these ones seem to pop up in everyone's 23andMe ancestry post or article.

All in all, this is a nice general overview of my maternal ancestry, but now I need to do some more digging. I will be posting about my paternal ancestry later this week.

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Each disease, condition etc is given a research confidence rating from 1-4 stars. A topic with four star rating means that they are "widely accepted by the scientific community".

Topics with lower ratings, 1-3 stars, means that they research "published in peer-reviewed journals but may not yet be widely accepted".

Here is a list of topics given four stars by 23andMe (Only topics A-C):

1) Age-related Macular Degeneration
2) Alcohol Flush Reaction
3) Bitter Taste Perception
4) Blood Groups
5) Breast Cancer
6) Colorectal Cancer
7) Crohn's Disease

Now here is how each of the above four star-topics apply to my own DNA:

Age-related Macular Degeneration

Can't remember my family history of developing AMD in older age, so I will probably be doing some family sleuthing on the subject.

The above average odds calculation will probably make me more likely to pay more attention to general antioxidant vitamin and zinc intake and more willing to say "yes" to the eye exam people when they want to do extra things to my eyes.

Alcohol Flush Reaction

Bitter Taste Perception

Looks like I have an 80% chance of not being able to taste certain bitter flavors. This probably correlates to why I don't put cream and sugar in my coffee when most of my friends load their coffees up.

My motto: The blacker and bolder the better.

Blood Groups

All this one does it show me how limited my knowledge is of blood "types" and blood in general. Man, I will be spending plenty more time on this one later.

Breast Cancer

I know men can develop breast cancer, too, but not to worried about this higher than average odds calculation.

Colorectal Cancer

Anyone know how this is usually detected? I know how prostate cancer is checked for, but not colorectal cancer (see my earlier post on prostate cancer).

Oh yeah, know I remember. Colonoscopy!

Crohn's Disease

I will be covering more four star-topics (D-Z) in later posts.

If you would like me to share my genetic profile with you, go here. You can also view all our 'My Genome' posts here.

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Lot's of people have been asking me if I got any interesting or bad news in my genetic profile. There's a handful of data packed into my genetic profile and I haven't yet gotten through all of it.

I think it would be a lot easier to just share my genome results with you guys so you can explore them yourself. Then we can all be on the same page and you can get a better feel for the service I'm experiencing.

This will also allow people like my mom to give me health advice tailored more to my actual genetic predispositions than general concerns.

I'm still going to post about my experiences and discoveries using 23andMe but now friends, family and readers can get up-close and personal with the company I've been talking about for the past few months.

Here's what you need to do so I can share my DNA results:

1) Sign up for a 23andMe demo account here.
2) Email me your 23andMe username at andrew@buzzyeah.com.
3) Or, instead you can just add "andrewmeyer".

Have fun exploring and let me know if you find anything interesting. Check out 23andMe's Help section if you have questions like "What information will other users see when I share with them?" or "How does genome sharing work?"

When you sign up for a 23andMe demo account the default is to let you explore genetic data for the fake Mendel family.

Hopefully, I'm more exciting than the Mendel family.

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