CHEM243

Welcome Fall 05 class

bradlejc@drexel.edu (Jean-Claude Bradley) — Wed, 28 Sep 2005 17:48:00 -0400

A few notes for those of you taking this course fully online in the Fall of 2005.

1) Class announcements will be made to this blog.
2) Subscribe to the blog by clicking on the Subscribe with Bloglines button at the top of the blog.
3) Quizzes and tests are in WebCT. For now all students must login as guest to http://webct.drexel.edu. If you don't have the password email me. Do not go through one.drexel.edu until I let you know that it is ready.
4) The first test will be around week 5. That will show up in WebCT when it is set up through one.drexel.edu

list of student blogs

bradlejc@drexel.edu (Jean-Claude Bradley) — Tue, 7 Jun 2005 09:56:00 -0400

Here is the list of blogs generated by students for the extra credit assignment. The idea was to find an application of 2 reaction that we learned about in class. Most of the blogs were submitted right before the deadline so there was no time to give feedback. There are errors in many of these and several do not adhere to the guidelines (especially linking to online peer-reviewed articles). However they are listed here to highlight the multiple uses of organic synthesis and the interesting variety in the ways of presenting such information on blogs.

Akshay's Orgo Blog
Priyaabraham
Sandhyamanivannanorgo
Smitha's blog
Gwen1000
JaspreetOrgo
Jennifer's Blog
Andu's Blog
Hydroxylamine Sri
J.D.'s blog

Lecture 028: Wheel of orgo 5

bradlejc@drexel.edu (Jean-Claude Bradley) — Sat, 4 Jun 2005 06:41:00 -0400

There were no questions for the exam so we did one last Wheel of Orgo to practice reactions from the whole course. There were 3 enol reaction patterns to identify in the first 2 syntheses. Then we synthesized a cat from glycine.

mp3 podcast Right-click and select "save target as" if downloading manually.

pdf Right-click and select "save target as" if downloading manually.

streaming screencast Flash

Lecture 028 pdf

bradlejc@drexel.edu (Jean-Claude Bradley) — Sat, 4 Jun 2005 00:22:00 -0400

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Lecture 027: make-up test 2 review

bradlejc@drexel.edu (Jean-Claude Bradley) — Thu, 2 Jun 2005 09:10:00 -0400

We went over some common mistakes made in test 2, mainly on enol chemistry.

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pdf Right-click and select "save target as" if downloading manually.

streaming screencast Flash

Lecture 027 pdf

bradlejc@drexel.edu (Jean-Claude Bradley) — Thu, 2 Jun 2005 00:21:00 -0400

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Lecture 026: Extra Credit Help

bradlejc@drexel.edu (Jean-Claude Bradley) — Sat, 28 May 2005 09:54:00 -0400

Here are directions for completing the extra credit for this class. In the screencast I show how to:
1) Download ChemSketch (only for Drexel students)
2) Use wikipedia and Google scholar to find an article with a relevant synthetic step.
3) Draw out the single step reaction with ChemSketch.
4) Use Paint to convert the ChemSketch work into a bitmap file.
5) Create a Flickr account to upload the bitmap file and create a tag. (Everyone in my classes use at least the "orgo" tag in Flickr.)
6) Find the url referencing the picture in Flickr using properties and insert into a blog post. (I also go through creating a Blogger account)
7) Give a brief description of the reaction and link to at least one peer-reviewed article.

Notice that all the services are completely free. A freeware version of Chemsketch is available here. I don't know how it compares to the Drexel version.

The example I used was the last step in the synthesis of ibuprofen - the hydrolysis of a nitrile. This is what it looks like.

Remember the last day to have the extra credit work done is Friday June 3, 2005 at midnight.

mp3 podcast Right-click and select "save target as" if downloading manually.

There is no pdf for this lecture.

streaming screencast Flash

Lecture 025: test 2 review

bradlejc@drexel.edu (Jean-Claude Bradley) — Thu, 26 May 2005 11:37:00 -0400

I gave the solutions to the extra enol problems I posted on Monday and answered questions about the test.

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streaming screencast Flash

Lecture 025 pdf

bradlejc@drexel.edu (Jean-Claude Bradley) — Thu, 26 May 2005 00:19:00 -0400

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Lecture 024: prob 12 d-h

bradlejc@drexel.edu (Jean-Claude Bradley) — Tue, 24 May 2005 11:43:00 -0400

We finished problem 12 on enol chemistry and completed the list of the patterns to look for in these syntheses. At the end of class I put up a few more problems of varying difficulty then assisted students in small groups. I'll post the solution to these on Wednesday.

The test will be available Wednesday afternoon, a little earlier because Sunday and Monday Korman is closed. I will answer questions on Wednesday concerning the test then if there is any time left we'll do another Wheel of Orgo. Online students make sure to email me your questions.

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pdf Right-click and select "save target as" if downloading manually.

streaming screencast Flash

Lecture 024

bradlejc@drexel.edu (Jean-Claude Bradley) — Tue, 24 May 2005 00:19:00 -0400

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Lecture 023: problem 12 a-d

bradlejc@drexel.edu (Jean-Claude Bradley) — Sat, 21 May 2005 08:28:00 -0400

We did some enol chemistry synthesis problems. If you are having trouble with this section make sure to see me after class or schedule an appointment so I can see how you are approaching the problems.

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pdf Right-click and select "save target as" if downloading manually.

streaming screencast Flash

Lecture 023 pdf

bradlejc@drexel.edu (Jean-Claude Bradley) — Sat, 21 May 2005 00:17:00 -0400

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Lecture 022: Wheel of Orgo 4

bradlejc@drexel.edu (Jean-Claude Bradley) — Thu, 19 May 2005 10:46:00 -0400

Another round of Wheel of Orgo. This time Sri won. All of the syntheses were designed to practice enol reactions.

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pdf Right-click and select "save target as" if downloading manually.

streaming screencast Flash

Lecture 022 pdf

bradlejc@drexel.edu (Jean-Claude Bradley) — Thu, 19 May 2005 00:16:00 -0400

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Lecture 021: rest of prob 11

bradlejc@drexel.edu (Jean-Claude Bradley) — Tue, 17 May 2005 09:58:00 -0400

We finished problem 11 (j-p) on enol reactions. It was a mix of Claisen condensations, malonate ester and acetoacetate ester syntheses. The last problem was an example of a Robinson annulation.

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pdf Right-click and select "save target as" if downloading manually.

streaming screencast Flash

Lecture 021 pdf

bradlejc@drexel.edu (Jean-Claude Bradley) — Tue, 17 May 2005 00:15:00 -0400

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Lecture 020: Wheel of Orgo 3

bradlejc@drexel.edu (Jean-Claude Bradley) — Sat, 14 May 2005 15:25:00 -0400

We played another Wheel of Orgo with the target products vanillin, TNT and DEET.
Mihir won this one.

I reduced the resolution of the Flash presentation to 800x600 so you don't need to scroll if you are running you desktop at 1024x768. For all prior lectures, you can avoid scrolling by increasing the resolution of your screen.

mp3 podcast Right-click and select "save target as" if downloading manually.

pdf Right-click and select "save target as" if downloading manually.

streaming screencast Flash

Lecture 020 pdf

bradlejc@drexel.edu (Jean-Claude Bradley) — Sat, 14 May 2005 00:13:00 -0400

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Lecture 019: prob 11

bradlejc@drexel.edu (Jean-Claude Bradley) — Thu, 12 May 2005 08:43:00 -0400

We covered most of problem 11 about enol reactions.
We will resume Wheel of Orgo on Friday.

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pdf Right-click and select "save target as" if downloading manually.

streaming screencast Flash

Lecture 019 pdf

bradlejc@drexel.edu (Jean-Claude Bradley) — Thu, 12 May 2005 00:12:00 -0400

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Lecture 018: Wheel of Orgo II

bradlejc@drexel.edu (Jean-Claude Bradley) — Sat, 7 May 2005 16:03:00 -0400

We played "Wheel of Orgo" again today, with the modification that I only counted a point for reactions only if they were correct. Again 3 points for completing the synthesis. We did 2 relatively simple syntheses then started one difficult one (vanillin). We didn't get the chance to finish that one so we'll resume next time. Again Sujeet ended up with the most points at the end.

I would encourage you to think of ways of finishing this synthesis with the reactions we have learned. It is a good way of consolidating the material in this class. You don't need to participate, you can pass your turn and you can join the game in progress.

If you are taking the class online and would like to participate in a future Wheel of Orgo session email me so that I can plan future sessions.

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pdf Right-click and select "save target as" if downloading manually.

streaming screencast Flash

Lecture 018 pdf

bradlejc@drexel.edu (Jean-Claude Bradley) — Sat, 7 May 2005 00:10:00 -0400

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Lecture 017: Review for Test 1 Make-up

bradlejc@drexel.edu (Jean-Claude Bradley) — Thu, 5 May 2005 08:03:00 -0400

Review from email questions, class questions and the questions most wrongly answered from test 1.

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streaming screencast Flash

Lecture 017 pdf

bradlejc@drexel.edu (Jean-Claude Bradley) — Thu, 5 May 2005 00:09:00 -0400

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