Comments for TB R&D Matters Blog http://www.newtbdrugs.org/blog Working Towards a Faster Cure for Tuberculosis Sat, 14 Jan 2012 21:32:46 +0000 hourly 1 http://wordpress.org/?v=3.1.3 Comment on TB R&D Weekly Update: Totally Drug-Resistant TB by Nelly Solomonia http://www.newtbdrugs.org/blog/2012/01/tb-rd-weekly-update-totally-drug-resistant-tb/comment-page-1/#comment-1252 Nelly Solomonia Sat, 14 Jan 2012 21:32:46 +0000 http://www.newtbdrugs.org/blog/?p=3394#comment-1252 A new molecular line probe assay for detecting XDR-TB is urgently needed. A new molecular line probe assay for detecting XDR-TB is urgently needed.

]]> Comment on TB Researcher William Bishai Named to Head New TB-HIV Institute at Mandela School of Medicine in Durban, South Africa by ANAND http://www.newtbdrugs.org/blog/2010/05/tb-researcher-william-bishai-named-to-head-new-tb-hiv-institute-at-mandela-school-of-medicine-in-durban-south-africa/comment-page-1/#comment-1211 ANAND Wed, 07 Dec 2011 23:35:00 +0000 http://blog.newtbdrugs.org/?p=969#comment-1211 TODAY HIV TOMORROW CURE, C/O Dr.RM.GENGAN K.ANAND D.Tech, ORGANIC CHEMISTRY, DURBAN UNIVERSITY OF TECHNOLOGY SOUTHAFRICA TODAY HIV TOMORROW CURE,
C/O Dr.RM.GENGAN
K.ANAND D.Tech,
ORGANIC CHEMISTRY,
DURBAN UNIVERSITY OF TECHNOLOGY
SOUTHAFRICA

]]> Comment on TB R&D Weekly Update: Podcast interview with Dr. Gyanu Lamicchane by Nelly Solomonia http://www.newtbdrugs.org/blog/2011/11/tb-rd-weekly-update-podcast-interview-with-dr-gyanu-lamicchane/comment-page-1/#comment-1158 Nelly Solomonia Thu, 10 Nov 2011 11:55:29 +0000 http://www.newtbdrugs.org/blog/?p=3325#comment-1158 Information is very interesting! information! more details would be appreciated. Information is very interesting! information! more details would be appreciated.

]]> Comment on Interview with Gyanu Lamicchane by WGND http://www.newtbdrugs.org/blog/2010/05/interview-with-gyanu-lamicchane/comment-page-1/#comment-1152 WGND Tue, 08 Nov 2011 21:47:31 +0000 http://blog.newtbdrugs.org/?p=903#comment-1152 [...] WGND Interview with Gyanu Lamicchane (May 13, 2010) [...] [...] WGND Interview with Gyanu Lamicchane (May 13, 2010) [...]

]]> Comment on International TB Research Roadmap Launched! by Nelly Solomonia http://www.newtbdrugs.org/blog/2011/11/international-tb-research-roadmap-launched/comment-page-1/#comment-1148 Nelly Solomonia Tue, 08 Nov 2011 11:00:04 +0000 http://www.newtbdrugs.org/blog/?p=3309#comment-1148 Very good report, but more detailed information about researches methodologies, especially about statistical analysis of study results are needed. I would like to share some my ideas: Ideas for TB researches Basic/Fundamental researches: • To create specific primers and molecular probes for detection of Isoniazid (and/or Z, E, IA, Fq..) resistance conferring mutations by automated molecular diagnostic (Gene Xpert MTB) technology. • To identify the M. tuberculosis genes which are responsible to induce synthesis of enzymes for all components of Mtb's cell wall; To find difference in cell wall structures of Latent and Active forms of M. tuberculosis. • Observation on changes in quantity of specific immune cells (e.g. Th1, INF-µ, IL or TNFα factors) during the treatment of TB/HIV(-) and TB/HIV(+) cases. Clinical Trials: • Participation in Clinical Trials of New TB drugs (e.g. Delamanid (OPC-67683), PA-824, TMC-207 or SQ-109) and Novel treatment regimens. Operational Researches: • To define reasons of DST profile changes in time of M/XDR-TB standard treatment. • To compare treatment outcomes in M/XDR-TB New and Previuously treated cases (including pediatric M/XDR-TB cases, with accent on all Bacteriological, Clinical and Epidemiological aspects of M/XDR-TB management). • To compare results of all used standard TB diagnostic tests (routine and new/rapid) in any specimens of PTB and EPTB cases (including pediatric TB cases). Ready to discuss all aspects. In my opinion, realization of web based international network between research institutions will help. sincerely, Nelly Slomonia Very good report, but more detailed information about researches methodologies, especially about statistical analysis of study results are needed.

I would like to share some my ideas:

Ideas for TB researches

Basic/Fundamental researches:

• To create specific primers and molecular probes for detection of Isoniazid (and/or Z, E, IA, Fq..) resistance conferring mutations by automated molecular diagnostic (Gene Xpert MTB) technology.

• To identify the M. tuberculosis genes which are responsible to induce synthesis of enzymes for all components of Mtb’s cell wall; To find difference in cell wall structures of Latent and Active forms of M. tuberculosis.
• Observation on changes in quantity of specific immune cells (e.g. Th1, INF-µ, IL or TNFα factors) during the treatment of TB/HIV(-) and TB/HIV(+) cases.
Clinical Trials:
• Participation in Clinical Trials of New TB drugs (e.g. Delamanid (OPC-67683), PA-824, TMC-207 or SQ-109) and Novel treatment regimens.
Operational Researches:

• To define reasons of DST profile changes in time of M/XDR-TB standard treatment.

• To compare treatment outcomes in M/XDR-TB New and Previuously treated cases (including pediatric M/XDR-TB cases, with accent on all Bacteriological, Clinical and Epidemiological aspects of M/XDR-TB management).

• To compare results of all used standard TB diagnostic tests (routine and new/rapid) in any specimens of PTB and EPTB cases (including pediatric TB cases).

Ready to discuss all aspects. In my opinion, realization of web based international network between research institutions will help.

sincerely,

Nelly Slomonia

]]> Comment on Winstone’s Voice by Kate Greenaway http://www.newtbdrugs.org/blog/2011/10/winstones-voice/comment-page-1/#comment-1108 Kate Greenaway Thu, 13 Oct 2011 16:48:54 +0000 http://www.newtbdrugs.org/blog/?p=3253#comment-1108 I'm at a real loss for words. Profoundly sad. He was one of the first people I met, back in the dark days when AIDS had Zambia firmly in its grip, when only a few had the courage to speak up. Winstone patiently and candidly articulated the experience of HIV for me (and so many others) who were floundering, grasping at straws, trying to understand HIV well enough to create programming that would respond... And he continued to do that over the years, first with promoting testing, then treatment, then TB/HIV which he represented from his heart as no one else could. The world is a better place because of his efforts. As we grieve, we must also rededicate ourselves to honoring his legacy, by reaching more people with better services. Rest in peace Winstone -- we'll take it from here! I’m at a real loss for words. Profoundly sad. He was one of the first people I met, back in the dark days when AIDS had Zambia firmly in its grip, when only a few had the courage to speak up. Winstone patiently and candidly articulated the experience of HIV for me (and so many others) who were floundering, grasping at straws, trying to understand HIV well enough to create programming that would respond… And he continued to do that over the years, first with promoting testing, then treatment, then TB/HIV which he represented from his heart as no one else could. The world is a better place because of his efforts. As we grieve, we must also rededicate ourselves to honoring his legacy, by reaching more people with better services. Rest in peace Winstone — we’ll take it from here!

]]> Comment on Press Release! WHO Warns of Consequences of Underfunding TB by Patrick Bertrand http://www.newtbdrugs.org/blog/2011/10/press-release-who-warns-of-consequences-of-underfunding-tb/comment-page-1/#comment-1107 Patrick Bertrand Thu, 13 Oct 2011 14:38:46 +0000 http://www.newtbdrugs.org/blog/?p=3247#comment-1107 How is it possible to have accurate data in countries where the health systems are not working properly? WHO should really focus its energy in strengthening health system and especially the reporting systems. How is it possible to have accurate data in countries where the health systems are not working properly? WHO should really focus its energy in strengthening health system and especially the reporting systems.

]]> Comment on Press Release! WHO Warns of Consequences of Underfunding TB by Christopher Locher http://www.newtbdrugs.org/blog/2011/10/press-release-who-warns-of-consequences-of-underfunding-tb/comment-page-1/#comment-1102 Christopher Locher Thu, 13 Oct 2011 14:33:06 +0000 http://www.newtbdrugs.org/blog/?p=3247#comment-1102 The WHO report may be true but remember what Ben Franklin said about statistics? The total number of TB cases may be declining; however, the number of multi-drug resistant and extensively drug resistant cases continues to rise each year. There are also geographical and lack of accurate reporting issues to be considered in the interpretation of the findings. The WHO report may be true but remember what Ben Franklin said about statistics? The total number of TB cases may be declining; however, the number of multi-drug resistant and extensively drug resistant cases continues to rise each year. There are also geographical and lack of accurate reporting issues to be considered in the interpretation of the findings.

]]> Comment on TB R&D Weekly Update: Early bactericidal activity of OPC-67683 by Nelly Solomonia http://www.newtbdrugs.org/blog/2011/07/tb-rd-weekly-update-early-bactericidal-activity-of-opc-67683/comment-page-1/#comment-990 Nelly Solomonia Thu, 14 Jul 2011 07:25:19 +0000 http://www.newtbdrugs.org/blog/?p=2928#comment-990 Good news. Early bacteriocidal activity of Delamanid is absolutely logical. This drug is very hopeful by affecting of Mtb cell wall (Mycolic acid) and inhibition of cell wall synthesis/respiration. I think it's will be critical to include Delamanid in novel combinations/regimens (as PA-824). Sincerely, Nelly Solomonia Good news. Early bacteriocidal activity of Delamanid is absolutely logical. This drug is very hopeful by affecting of Mtb cell wall (Mycolic acid) and inhibition of cell wall synthesis/respiration. I think it’s will be critical to include Delamanid in novel combinations/regimens (as PA-824).

Sincerely,

Nelly Solomonia

]]> Comment on TB R&D Weekly Update: Latent TB Treatment in HIV and Children by emedist.com http://www.newtbdrugs.org/blog/2011/07/tb-rd-weekly-update-latent-tb-treatment-in-hiv-and-children/comment-page-1/#comment-984 emedist.com Thu, 07 Jul 2011 11:09:00 +0000 http://www.newtbdrugs.org/blog/?p=2918#comment-984 <strong>Combination therapy as good as old regimen to prevent full-blown TB in people with/without HIV...</strong> ScienceDaily (July 6, 2011) — Johns Hopkins and South African scientists have further compelling evidence that new, simpler and shorter treatments with antibiotic drugs could dramatically help prevent tens of millions of people worldwide already infec.... Combination therapy as good as old regimen to prevent full-blown TB in people with/without HIV…

ScienceDaily (July 6, 2011) — Johns Hopkins and South African scientists have further compelling evidence that new, simpler and shorter treatments with antibiotic drugs could dramatically help prevent tens of millions of people worldwide already infec….

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