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    <title>Dana Foundation Blog</title>
    
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    <id>tag:typepad.com,2003:weblog-1873231</id>
    <updated>2013-05-23T09:21:18-04:00</updated>
    <subtitle>News and views on brain science, neuroethics, and neuroeducation  -  www.dana.org</subtitle>
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    <atom10:link xmlns:atom10="http://www.w3.org/2005/Atom" rel="self" type="application/atom+xml" href="http://feeds.feedburner.com/DanaFoundationBlog" /><feedburner:info uri="danafoundationblog" /><atom10:link xmlns:atom10="http://www.w3.org/2005/Atom" rel="hub" href="http://pubsubhubbub.appspot.com/" /><entry>
        <title>From the Archives: Brenda Milner</title>
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        <id>tag:typepad.com,2003:post-6a01156f9c01e7970c01901c7c4cfb970b</id>
        <published>2013-05-23T09:21:18-04:00</published>
        <updated>2013-05-23T09:27:08-04:00</updated>
        <summary>The researcher famed for her work with amnesiac Patient H.M. continues to advance the field.</summary>
        <author>
            <name>Dana</name>
        </author>
        <category scheme="http://www.sixapart.com/ns/types#category" term="Dana Alliance for Brain Initiatives" />
        <category scheme="http://www.sixapart.com/ns/types#category" term="From the Archives" />
        <category scheme="http://www.sixapart.com/ns/types#category" term="memory" />
        
        <category scheme="http://sixapart.com/ns/types#tag" term="DABI" />
        <category scheme="http://sixapart.com/ns/types#tag" term="from the archives" />
        <category scheme="http://sixapart.com/ns/types#tag" term="memory" />
        <category scheme="http://sixapart.com/ns/types#tag" term="Neuroethics" />
        
<content type="xhtml" xml:lang="en-US" xml:base="http://danapress.typepad.com/weblog/"><div xmlns="http://www.w3.org/1999/xhtml"><p>Most
of us know researcher and Dana Alliance member Brenda Milner from her
decades-long work with amnesiac Patient H.M. (Henry Molaison) and the peek into
memory he offered. While Mr. Molaison died in 2008, she still is at the lab
bench, continuing to delve into the mind and brain. </p>
<p>In
<a href="http://www.nytimes.com/2013/05/21/science/still-charting-memorys-depths.html?pagewanted=all&amp;_r=0" target="_blank">this week’s <em>New York Times</em></a>, she told interviewer Claudia Dreifus she’s working
to tease out what are left/right brain differences. Here’s my favorite
exchange:</p>
<blockquote>
<p>We all loved H.M. Yet it was very
strange, psychologically, because when he died we all felt as if we’d lost a
friend. And this is funny because one thinks of friendship as a bilateral
thing. He didn’t recognize us or know us, and we felt we’d lost a friend.</p>
</blockquote>
<p>
We also did a <a href="http://www.dana.org/news/features/detail.aspx?id=26086">Q&amp;A with Milner</a>, in 2010, with this fabulous photo of her: </p>
<div class="photo-wrap photo-xid-6a01156f9c01e7970c01901c7c45f8970b" id="photo-xid-6a01156f9c01e7970c01901c7c45f8970b" style="display: block; margin-left: auto; margin-right: auto; width: 294px;"><a class="asset-img-link" href="http://danapress.typepad.com/.a/6a01156f9c01e7970c01901c7c45f8970b-pi"><img alt="Brenda Milner" class="asset  asset-image at-xid-6a01156f9c01e7970c01901c7c45f8970b" src="http://danapress.typepad.com/.a/6a01156f9c01e7970c01901c7c45f8970b-320wi" title="Brenda Milner" /></a>
<div class="photo-caption caption-xid-6a01156f9c01e7970c01901c7c45f8970b" id="caption-xid-6a01156f9c01e7970c01901c7c45f8970b">Photographer: Owen Egan; Courtesy of the Montreal Neurological Institute, McGill University</div>
</div>

    She
was generous with her time, and just as excited about her work. And she gave us
great quotes, like this one:
<blockquote>
<p>I had a chance to change fields at
the end of the first year, and I thought, ‘I’ll do philosophy!’ And then people
from my college said, ‘Brenda, don’t you have to earn a living?’ (I was as poor
as a church mouse then, I was on scholarships.) They said, ‘No one ever learned
a living doing philosophy, so forget that!’ And now comes the real bit of luck.
In England, in Cambridge pre-World War II, experimental psychology was grouped
with philosophy and ethics, under the “moral sciences.” Since I had mentioned
philosophy, they suggested psychology because [as a psychologist] you could
always get a job as a factory inspector.</p>
<p>Then I discovered I was good at
it. I was a good observer and I enjoyed working with people in the lab. But it
was luck, you see. I didn’t even know what psychology was!</p>
</blockquote>
<p>In
2007, a Dana Gray Matters radio segment featured her work with Mr. Molaison—you
can <a href="http://www.dana.org/swf/mp3pop.aspx?url=rtmp://media.dana.org/dana/audio/070107_patienthm.mp3" target="_self" title="Milner audio">listen to</a> or <a href="http://www.dana.org/WorkArea/showcontent.aspx?id=8798" target="_self" title="Milner transcript">read a transcript</a> of the segment, which includes the voices of
both Dr. Milner and Mr. Molaison. Following Mr. Molaison’s death, the Dana
Foundation partially funded the <a href="http://www.dana.org/news/publications/detail.aspx?id=20838#special_case_patient_hm" target="_self" title="dissection and digital preservation of his brain">dissection and digital preservation of his brain</a> as part of the Brain Observatory Project. Now we all
can be brain researchers. Investigate the micrometer-thin slices built into 3-D
images and see what in his surgically damaged anatomy could have led to the
extreme and specific memory losses he showed.</p>
<p>--Nicky
Penttila</p><xhtml:img xmlns:xhtml="http://www.w3.org/1999/xhtml" src="http://feeds.feedburner.com/~r/DanaFoundationBlog/~4/Oj3zUdHcofg" height="1" width="1" /></div></content>


        <link rel="enclosure" type="audio/mpeg" href="http://www.dana.org/swf/mp3pop.aspx?url=rtmp://media.dana.org/dana/audio/070107_patienthm.mp3" />

    <feedburner:origLink>http://danapress.typepad.com/weblog/2013/05/from-the-archives-brenda-milner.html</feedburner:origLink></entry>
    <entry>
        <title>Does 'Psychiatry's Bible' Need to Be Rewritten?</title>
        <link rel="alternate" type="text/html" href="http://feedproxy.google.com/~r/DanaFoundationBlog/~3/cz6G6GVFFNE/does-psychiatrys-bible-need-to-be-rewritten.html" />
        <link rel="replies" type="text/html" href="http://danapress.typepad.com/weblog/2013/05/does-psychiatrys-bible-need-to-be-rewritten.html" thr:count="1" thr:updated="2013-05-22T11:16:58-04:00" />
        <id>tag:typepad.com,2003:post-6a01156f9c01e7970c0192aa3255bc970d</id>
        <published>2013-05-22T10:56:13-04:00</published>
        <updated>2013-05-22T10:56:13-04:00</updated>
        <summary>Live chat tomorrow at 3pm about the controversy surrounding the new edition of the Diagnostic and Statistical Manual of Mental Disorders. Hosted by Science Magazine.</summary>
        <author>
            <name>Dana</name>
        </author>
        <category scheme="http://www.sixapart.com/ns/types#category" term="Events" />
        <category scheme="http://www.sixapart.com/ns/types#category" term="Media" />
        <category scheme="http://www.sixapart.com/ns/types#category" term="mental health" />
        <category scheme="http://www.sixapart.com/ns/types#category" term="Neuroethics" />
        
        <category scheme="http://sixapart.com/ns/types#tag" term="Diagnostic and Statistical Manual of Mental Disorders" />
        <category scheme="http://sixapart.com/ns/types#tag" term="DSM 5" />
        <category scheme="http://sixapart.com/ns/types#tag" term="DSM-5" />
        <category scheme="http://sixapart.com/ns/types#tag" term="mental disorders" />
        <category scheme="http://sixapart.com/ns/types#tag" term="mental health" />
        <category scheme="http://sixapart.com/ns/types#tag" term="Science Magazine" />
        
<content type="xhtml" xml:lang="en-US" xml:base="http://danapress.typepad.com/weblog/"><div xmlns="http://www.w3.org/1999/xhtml"><p>During <a href="http://www.dana.org/news/cerebrum/detail.aspx?id=23560#McHugh_jump">the development</a> and now <a href="http://www.nytimes.com/2013/05/07/health/psychiatrys-new-guide-falls-short-experts-say.html?src=rechp&amp;_r=1&amp;">the release</a> of the Fifth Edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5), there has been a lot of debate among those in the neuroscience community about how disorders should be diagnosed and whether certain categorizations are too far-reaching. </p>
<p>Dana Alliance member and Director of the National Institutes for Mental Health Tom Insel <a href="http://www.nimh.nih.gov/about/director/2013/transforming-diagnosis.shtml">recently argued</a>:</p>
<blockquote>
<p>the DSM diagnoses are based on a consensus about clusters of clinical symptoms, not any objective laboratory measure. In the rest of medicine, this would be equivalent to creating diagnostic systems based on the nature of chest pain or the quality of fever… Patients with mental disorders deserve better.</p>
</blockquote>

    <a href="http://www.dana.org/media/detail.aspx?id=29478">Dana grantee</a> and bioethicist <a href="http://ideas.time.com/2013/05/21/viewpoint-stop-critiquing-the-dsm-5/">Art Caplan came to the defense of the manual</a>, offering a rebuttal to Insel’s argument,
<blockquote>
<p>The view that the only medical classifications that are valuable are those grounded in molecular biology can be dismissed out of hand. Meteorologists predicting the weather, climate scientists studying global warming, forestry experts, and those dealing with earthquakes do not have coherent explanations in atomic physics for their categories or for their causes. But their categories are accepted because they work—giving us predictable and actionable knowledge about the world. The same ought be the test of DSM 5.<br /><br /></p>
</blockquote>
<p>Clearly there are strong opinions surrounding the DSM-5, and the debate will surely continue. And you can participate, or at least listen in:  Tomorrow (Thursday), <a href="http://news.sciencemag.org/sciencenow/2013/05/live-chat-does-psychiatrys-bible.html#.UZpv5i1jJZI.twitter"><em>Science Magazine</em> will host a live chat at 3 pm</a>, featuring three experts with varying opinions. Submit your questions to them in the comments section <a href="http://news.sciencemag.org/sciencenow/2013/05/live-chat-does-psychiatrys-bible.html#.UZpv5i1jJZI.twitter">here</a>.</p>
<p>--Ann L. Whitman</p><xhtml:img xmlns:xhtml="http://www.w3.org/1999/xhtml" src="http://feeds.feedburner.com/~r/DanaFoundationBlog/~4/cz6G6GVFFNE" height="1" width="1" /></div></content>



    <feedburner:origLink>http://danapress.typepad.com/weblog/2013/05/does-psychiatrys-bible-need-to-be-rewritten.html</feedburner:origLink></entry>
    <entry>
        <title>Social and Emotional Learning</title>
        <link rel="alternate" type="text/html" href="http://feedproxy.google.com/~r/DanaFoundationBlog/~3/5u4YziyeA30/social-and-emotional-learning.html" />
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        <id>tag:typepad.com,2003:post-6a01156f9c01e7970c019102580d61970c</id>
        <published>2013-05-20T11:35:34-04:00</published>
        <updated>2013-05-20T11:35:34-04:00</updated>
        <summary>At a recent NYAS event, Amishi Jha, Ph.D., said that children should be given better mental training to help them absorb the information they are taught.</summary>
        <author>
            <name>Dana</name>
        </author>
        <category scheme="http://www.sixapart.com/ns/types#category" term="children" />
        <category scheme="http://www.sixapart.com/ns/types#category" term="Events" />
        
        <category scheme="http://sixapart.com/ns/types#tag" term="Amishi Jha" />
        <category scheme="http://sixapart.com/ns/types#tag" term="attention" />
        <category scheme="http://sixapart.com/ns/types#tag" term="children" />
        <category scheme="http://sixapart.com/ns/types#tag" term="education" />
        <category scheme="http://sixapart.com/ns/types#tag" term="NYAS" />
        
<content type="xhtml" xml:lang="en-US" xml:base="http://danapress.typepad.com/weblog/"><div xmlns="http://www.w3.org/1999/xhtml"><p>Formal education
often does not address the social and emotional backgrounds of children and
their ability to learn, according to Ingrid Wickelgren, moderator at a recent New
York Academy of Sciences (NYAS) event titled <em>Social and Emotional Learning: Preparing our Children to Excel</em>. She
argued that parents and other caregivers send children to school, assuming that
the teacher will pour math, reading, and science into their tiny little
brains. Bam! Done! In reality, learning is infinitely more
complicated—some students are better-behaved, pay closer attention, complete homework
assignments, and others don’t. The level of learning, she pointed out, is due
to differences in executive functions such as attention, memory, planning skills, problem solving, and task
switching in the brain. While
being presented with new information
and skills, children should also be given better ways such as mindfulness and
other mental training to absorb and learn that information.</p>
<p>One of the event’s speakers,
Amishi Jha, Ph.D., associate professor of psychology at the University of Miami, focused on the concept of mindfulness, defining it as
“a mental mode characterized by attention to present moment experience without
conceptual elaboration or emotional reactivity.” At first, I wondered: Is she
suggesting that we don’t use our brains to think? Am I “mindful”? Jha said mindfulness
can train our brains to function more efficiently and calmly, without analyzing
or thinking about the past or future. Most importantly, it can improve
attention and other executive functions.</p>


<p>She then addressed
the concept of “wandering attention,” a phrase coined by psychologist William
James, who believed taming wandering attention produces an excellent education.
Jha agrees. Wandering attention is a central issue in brain conditions such as
ADHD, but it also refers to losing one’s focus. To test our ability to manage
selective attention and resist distraction, Jha asked us to close our eyes,
select one aspect of our breathing, and focus on it. I thought about coffee,
the Lincoln biography I’m reading, how I would get home from the event, etc. She
prompted the audience to “gently return our attention” and remarked that we
probably weren’t aware that our thoughts had wandered – often a subconscious
action caused by the way our brains are wired. She told us that mind wandering can have
harmful effects on a person’s well-being when manifested as “rumination or
worry” but, positive effects when expressed as “constructive internal reflection.”</p>
<p><iframe frameborder="0" height="315" src="http://www.youtube.com/embed/0g6gOPXecqc" width="420" /><br /><br /></p>
<p>Clancy Blair, Ph.D,
professor of applied psychology at New York
University, focused
his discussion on executive functions, the
biochemical processes that occur between lymphatic structures in the brain and
the pre-frontal cortex, and the effects of stress on children. Stress that, like mind wandering, can have harmful
or beneficial effects on an individual, and has a motivating effect only when normal
stressors are managed properly and neuroendocrine hormones don’t surpass a personal
threshold. Stress physiology that involves hormones and glucocorticoids from
the hypothalamus affecting the pre-frontal lobe and vice versa is complex, and
yet to pinpoint the social and emotional causes of excess stress may be equally
as complicated. Executive functions are
affected by genes, stress physiology, environment, and other aspects of a
person’s life, but are also shaped by them. It is a highly reciprocal relationship. </p>
<p>Blair argued that in
many cases, severe poverty and reactive parenting are primary stressors for
young children and affect their ability to learn. He added that “the environment shapes brain
development in ways appropriate for the context.” Children
who are constantly under stress have biochemical and physiological responses
that are appropriate for survival, yet not ideal for learning. In “low quality environments,” children have
abnormally high baseline levels of cortisol and other stress hormones that
don’t peak drastically during highly stressful situations, unlike their counterparts
from “high-quality” environments.</p>
<p>To Blair,
resilience or coping with stress by exerting control over a seemingly
uncontrollable situation is the most important solution for improving executive
functioning. Many programs Blair and Jha
mentioned, including <a href="http://www.toolsofthemind.org/">Tools of the Mind</a> for Kindergarteners, SMART and <a href="http://www.care.org/index.asp">CARE</a> for adults
and <a href="http://www.susankaisergreenland.com/inner-kids.html">InnerKids</a>, for K-12 students, have shown
promise for improving attention and executive functioning. Mindfulness training and other techniques will
not only improve school-aged learning but also, as Jha put it, “reduce
suffering” for diverse groups of people, from returning war veterans, to college
students, to adults and seniors. Its potential is huge, she believes. To learn
more about <a href="http://www.nyas.org/Events/Default.aspx">upcoming events</a> at the New York Academy of
Sciences, visit their <a href="http://www.nyas.org/Events/Default.aspx">website</a>. </p>
<p>--Amanda Bastone</p><xhtml:img xmlns:xhtml="http://www.w3.org/1999/xhtml" src="http://feeds.feedburner.com/~r/DanaFoundationBlog/~4/5u4YziyeA30" height="1" width="1" /></div></content>



    <feedburner:origLink>http://danapress.typepad.com/weblog/2013/05/social-and-emotional-learning.html</feedburner:origLink></entry>
    <entry>
        <title>Dana Newsletter: May</title>
        <link rel="alternate" type="text/html" href="http://feedproxy.google.com/~r/DanaFoundationBlog/~3/Ikib8u6cAho/dana-newsletter-may.html" />
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        <id>tag:typepad.com,2003:post-6a01156f9c01e7970c017eeb450fe6970d</id>
        <published>2013-05-17T11:50:47-04:00</published>
        <updated>2013-05-17T11:50:47-04:00</updated>
        <summary>The Dana news email blast for May 2013.</summary>
        <author>
            <name>Dana</name>
        </author>
        <category scheme="http://www.sixapart.com/ns/types#category" term="Dana publications" />
        <category scheme="http://www.sixapart.com/ns/types#category" term="News" />
        
        <category scheme="http://sixapart.com/ns/types#tag" term="Dana news email blast" />
        <category scheme="http://sixapart.com/ns/types#tag" term="dana newsletter neuroscience" />
        
<content type="xhtml" xml:lang="en-US" xml:base="http://danapress.typepad.com/weblog/"><div xmlns="http://www.w3.org/1999/xhtml"><p>Below is the latest Dana email newsletter. You can sign up to receive this (and other Dana email alerts and/or print publications) by going <a href="http://dana.org/MemberLogin.aspx?ReturnUrl=%2fmembership%2fSubscriptions.aspx" target="_self">here</a>.</p>
<h2><a href="http://email.dana.org/c.html?ufl=3&amp;rtr=on&amp;s=awru,11arc,1age,4mdt,bfu5,55o7,cumu">Sound
the Alarm: Fraud in Neuroscience</a></h2>
<p><strong><span style="font-size: 8pt;">by Stephen G. Lisberger, Ph.D.</span></strong></p>
<p>
By all accounts, scientific misconduct over the
last decade is on the rise, especially in the area of journal retractions. In
neuroscience, our author -- both a leading academic and an experienced
neuroscience journal editor -- believes the field is detecting "only the
tip of the fraud iceberg." His story addresses the nature, detection, and
incentives for fraud, and suggests reforms. From <em><a href="http://email.dana.org/c.html?ufl=3&amp;rtr=on&amp;s=awru,11arc,1age,cg42,i6cp,55o7,cumu">Cerebrum</a></em>,
our online magazine of ideas.</p>


<h3><a href="http://email.dana.org/c.html?ufl=3&amp;rtr=on&amp;s=awru,11arc,1age,6qfb,2j07,55o7,cumu">Artificial
Sight</a></h3>
<p>The development of retinal prostheses to
generate artificial vision for blind people is a complex, long-term, expensive,
and interdisciplinary undertaking. The FDA has approved the first such device
and here's how it works. One of our series of <a href="http://email.dana.org/c.html?ufl=3&amp;rtr=on&amp;s=awru,11arc,1age,c5pw,77c6,55o7,cumu">Reports
on Progress</a>.</p>
<h3><a href="http://email.dana.org/c.html?ufl=3&amp;rtr=on&amp;s=awru,11arc,1age,lgsi,8tq0,55o7,cumu">Memory
-- A Primer</a></h3>
<p>Thanks to a century of memory research, we
know a good deal about its operation: what happens in the brain when we store
facts, experiences, and skills in memory; what happens when we recall them. One
of our series of <a href="http://email.dana.org/c.html?ufl=3&amp;rtr=on&amp;s=awru,11arc,1age,kolt,8bm9,55o7,cumu">Primers</a>.</p>
<h3><a href="http://email.dana.org/c.html?ufl=3&amp;rtr=on&amp;s=awru,11arc,1age,1ayf,8z6w,55o7,cumu">To
Stave off Alzheimer's, Stay Hungry?</a></h3>
<p>Researchers hope that the '5:2 diet' and
other eating-restriction techniques can prevent age-related neurodegeneration
and extend the working life of the brain.</p>
<h3><a href="http://email.dana.org/c.html?ufl=3&amp;rtr=on&amp;s=awru,11arc,1age,6748,tyj,55o7,cumu">The
Law to Neuroscience: Hold Up</a></h3>
<p>Much of what we "know" from
neuroscience research is not ready -- yet -- for use in the courtroom, argued
panelists during a forum April 25 in Washington, DC. A webcast from the
Neuroscience and Law series, sponsored by the Dana Foundation, AAAS, The
MacArthur Foundation Research Network on Law and Neuroscience, and the
International Neuroethics Society.</p>
See also: <a href="http://email.dana.org/c.html?ufl=3&amp;rtr=on&amp;s=awru,11arc,1age,gozf,bchd,55o7,cumu">Dana
blog: Write-up of the Neuroscience and the Law event</a><xhtml:img xmlns:xhtml="http://www.w3.org/1999/xhtml" src="http://feeds.feedburner.com/~r/DanaFoundationBlog/~4/Ikib8u6cAho" height="1" width="1" /></div></content>



    <feedburner:origLink>http://danapress.typepad.com/weblog/2013/05/dana-newsletter-may.html</feedburner:origLink></entry>
    <entry>
        <title>Are Genetics the Key to Solving Brain Disorders?</title>
        <link rel="alternate" type="text/html" href="http://feedproxy.google.com/~r/DanaFoundationBlog/~3/-JFHz88M30k/genetics-maria-karayiorgou.html" />
        <link rel="replies" type="text/html" href="http://danapress.typepad.com/weblog/2013/05/genetics-maria-karayiorgou.html" thr:count="1" thr:updated="2013-05-17T14:17:50-04:00" />
        <id>tag:typepad.com,2003:post-6a01156f9c01e7970c017eeb44c544970d</id>
        <published>2013-05-17T10:55:41-04:00</published>
        <updated>2013-05-17T11:13:41-04:00</updated>
        <summary>At a Dana-sponsored lecture, Maria Karayiorgou, M.D., spoke about her lab's often frustrating research into genetics.</summary>
        <author>
            <name>Dana</name>
        </author>
        <category scheme="http://www.sixapart.com/ns/types#category" term="Events" />
        
        <category scheme="http://sixapart.com/ns/types#tag" term="autism" />
        <category scheme="http://sixapart.com/ns/types#tag" term="Columbia University" />
        <category scheme="http://sixapart.com/ns/types#tag" term="genetics" />
        <category scheme="http://sixapart.com/ns/types#tag" term="human genome" />
        <category scheme="http://sixapart.com/ns/types#tag" term="Maria Karayiorgou" />
        <category scheme="http://sixapart.com/ns/types#tag" term="Mind Brain Behavior Institute" />
        <category scheme="http://sixapart.com/ns/types#tag" term="schizophrenia" />
        
<content type="xhtml" xml:lang="en-US" xml:base="http://danapress.typepad.com/weblog/"><div xmlns="http://www.w3.org/1999/xhtml"><p>A
Dana Foundation-sponsored lecture by Maria Karayiorgou, M.D., a professor of
psychiatry at Columbia University’s Mind Brain Behavior Institute, was a mind
boggling, roller coaster ride on the track where neuroscience is pinning much
of its hopes: genetics.</p>
<p>Karayiorgou’s
lecture was a bit like a trip down <em>Alice in
Wonderland’s</em> rabbit hole: the more she and her colleagues uncover, it
seems, the further away they are from definitive answers. One reason: The
average adult human brain has 80 billion neurons; each neuron has multiple
connections. Those connections may number in the trillions, or even
quadrillions. Meanwhile, of the 20,000 genes recently discovered in the Human
Genome Project, 80 percent relate to the brain.</p>

<p>First
trained as a medic and psychiatrist in Athens, Karayiorgou realized that the
genome was the key to unraveling the behavioral expressions that accompany so
many mental disorders. She studied genetics at M.I.T. and Rockefeller
University before landing at Columbia in 2006.</p>
<p>Last
night, she announced that her lab recently made an important discovery: a
chromosome (22-Q11) that potentially leads to schizophrenia in 30 percent of
all individuals. “This is a powerful discovery because it’s the first time we
have uncovered a genetic factor with such strong, predictive value,” she said,
adding that “it will inspire research programs around the world to try to focus
on predictive factors.” </p>
<p>Karayiorgou
said it was “a dream come true” to be the first lab to sequence the genes of
300 families. She looked at genes for schizophrenia and autism across all
20,000 genes and found that new mutations were not inherited, but generated
anew. But the biggest surprise was that the mutations occurred in many more
genes than expected. While they had given up on the idea of a single gene
disorder, the thinking was that maybe a dozen or two genes were involved in a
disorder such as schizophrenia. The new research put the number between 500 and
1,000.</p>
<p>She
compared the reaction to the findings as “hitting rock bottom,” followed by
denial, anger, and acceptance. But then came the positive spin: “It’s really
not so bad; maybe even empowering.”</p>
<p>On
the screen appeared the opening sentence of <em>Anna
Karana</em>, published in 1877: “Funny enough, Tolstoy may have predicted it
first when he wrote that ‘happy families are all alike; every unhappy family is
unhappy in its own way,’” she said. “Extrapolate that to mean that every
patient has their own disease-causing mutation.” </p>
<p>--Bill
Glovin</p><xhtml:img xmlns:xhtml="http://www.w3.org/1999/xhtml" src="http://feeds.feedburner.com/~r/DanaFoundationBlog/~4/-JFHz88M30k" height="1" width="1" /></div></content>



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