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	<lastBuildDate>Mon, 09 Dec 2024 09:06:48 +0000</lastBuildDate>
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	<itunes:explicit>no</itunes:explicit><copyright>www.dewabola.club</copyright><itunes:image href="https://lh3.googleusercontent.com/-zBcoYR9FdYA/V3uU9hzagrI/AAAAAAAAAMk/0HVQfGCsgUY7yGwV6ZNA36IxcdDh-d5OQCKgB/w140-h140-p/Livescore-Terbaru-Hari-Ini-Dewa-Bola.png"/><itunes:keywords>Dewa,Bola,Game,Bola,Online,Gadis,Bola,Pemain,Bola,Livescore,Terbaru,Prediksi,Skor,Pemain,Bola,Bookie</itunes:keywords><itunes:summary>Situs Game Bola Online, Prediksi Skor, Gadis Bola, Pemain Bola dan Livescore hingga Bookie terbaru Indonesia.</itunes:summary><itunes:subtitle>Dewa Bola - Club Bola Online</itunes:subtitle><itunes:category text="Sports &amp; Recreation"/><itunes:author>Dewa Bola</itunes:author><itunes:owner><itunes:email>dewabolanet@gmail.com</itunes:email><itunes:name>Dewa Bola</itunes:name></itunes:owner><item>
		<title>N.J. boys XC state champion earns Top 5 finish at Nike Nationals</title>
		<link>https://www.bookiebola.club/2024/12/09/n-j-boys-xc-state-champion-earns-top-5-finish-at-nike-nationals/</link>
		
		
		<pubDate>Mon, 09 Dec 2024 09:06:48 +0000</pubDate>
				<category><![CDATA[News]]></category>
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					<description><![CDATA[Christian Brothers, N.J.’s No. 1 team, took to the hills in one of the biggest meets of the nation and came away with a big-time finish despite the rainy conditions and muddy course. The Colts didn’t have their best race at Glendoveer Golf Course in Portland, OR as they competed for a national title at the Nike Cross Country Nationals (NXN), but they ultimately finishing fifth in the team standings, improving upon the sixth-place finish from 2023.]]></description>
										<content:encoded><![CDATA[<p>Christian Brothers, N.J.’s No. 1 team, took to the hills in one of the biggest meets of the nation and came away with a big-time finish despite the rainy conditions and muddy course.<br />
The Colts didn’t have their best race at Glendoveer Golf Course in Portland, OR as they competed for a national title at the Nike Cross Country Nationals (NXN), but they ultimately finishing fifth in the team standings, improving upon the sixth-place finish from 2023.</p>
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			<dc:creator>dewabolanet@gmail.com (Dewa Bola)</dc:creator></item>
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		<title>Auto sales in November up 8.8 per cent: DesRosiers</title>
		<link>https://www.bookiebola.club/2024/12/06/auto-sales-in-november-up-8-8-per-cent-desrosiers/</link>
		
		
		<pubDate>Fri, 06 Dec 2024 05:08:11 +0000</pubDate>
				<category><![CDATA[Business]]></category>
		<guid isPermaLink="false">https://www.bookiebola.club/2024/12/06/auto-sales-in-november-up-8-8-per-cent-desrosiers/</guid>

					<description><![CDATA[TORONTO &#8211; DesRosiers Automotive Consultants says November auto sales were the best for the month since record-breaking sales in 2017. The agency says auto sales were up 8.8 per cent compared with the same time last year, as the market picked up in the fall. DesRosiers says there was an additional selling day in November this year compared with last year as 156,000 light vehicles were sold last month. Andrew King, managing partner at DesRosiers, says the market has already topped the 2023 year-end sales total of 1.72 million, with December expected to bring more sales. DesRosiers says while the…]]></description>
										<content:encoded><![CDATA[<p>TORONTO &#8211; DesRosiers Automotive Consultants says November auto sales were the best for the month since record-breaking sales in 2017.<br />
The agency says auto sales were up 8.8 per cent compared with the same time last year, as the market picked up in the fall.<br />
DesRosiers says there was an additional selling day in November this year compared with last year as 156,000 light vehicles were sold last month.<br />
Andrew King, managing partner at DesRosiers, says the market has already topped the 2023 year-end sales total of 1.72 million, with December expected to bring more sales.<br />
DesRosiers says while the total for the year will remain below pre-pandemic levels, strong fall sales have boosted results above those seen in the last three years.<br />
The firm added that easing supply chain woes in the auto sector helped push sales higher this year.<br />
This report by The Canadian Press was first published Dec. 4, 2024.</p>
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			<dc:creator>dewabolanet@gmail.com (Dewa Bola)</dc:creator></item>
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		<title>Nick Candy-backed miner eyes Condor Gold takeover</title>
		<link>https://www.bookiebola.club/2024/12/02/nick-candy-backed-miner-eyes-condor-gold-takeover/</link>
		
		
		<pubDate>Mon, 02 Dec 2024 17:16:36 +0000</pubDate>
				<category><![CDATA[EXPLORE]]></category>
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					<description><![CDATA[A London goldminer backed by the financier Nick Candy has made an offer for a rival in the latest example of the consolidation that has swept the sector as the price of gold has touched new highs this year. Metals Exploration, which trades on London’s junior Aim market and is 38 per cent owned by Candy’s investment vehicle, has said that it is in advanced discussions over a bid for Condor Gold, which would form a company worth about £150 million. Condor Gold, which is also listed on Aim as well as in Toronto, owns mines in Nicaragua and has…]]></description>
										<content:encoded><![CDATA[<p>A London goldminer backed by the financier Nick Candy has made an offer for a rival in the latest example of the consolidation that has swept the sector as the price of gold has touched new highs this year.<br />
Metals Exploration, which trades on London’s junior Aim market and is 38 per cent owned by Candy’s investment vehicle, has said that it is in advanced discussions over a bid for Condor Gold, which would form a company worth about £150 million.<br />
Condor Gold, which is also listed on Aim as well as in Toronto, owns mines in Nicaragua and has been focused on developing its La India project there. The loss-making company, which is chaired by the Scottish billionaire Jim Mellon, first sought a buyer for its La India assets in 2022.<br />
Metals Exploration is focused on assets in the Philippines and expects to produce more than 80,000 ounces of gold this year. It generated revenue of $91 million and a pre-tax profit of $58 million in the first six months of the year.<br />
Shares in Condor Gold were trading 22.5 per cent higher at 29½p in morning trading on Monday in London.<br />
Condor said it had also received another non-binding offer from Calibre Mining, a Canadian goldminer with assets across North America and Nicaragua.<br />
Calibre confirmed that it had been interested in acquiring the La India project but said it was not currently in discussions with Condor. “At this time, unless Condor is willing to re-engage in meaningful discussions, Calibre does not envision completing an acquisition,” the company said.<br />
Goldminers have sought to capitalise on the rally in the price of gold by snapping up assets in the sector. In September, Centamin, then a FTSE 250 goldminer, recommended a $2.5 billion takeover offer from AngloGold Ashanti, an American rival.<br />
The price of gold hit a record $2,790 per troy ounce in October and currently trades at about $2,651 after rallying 30 per cent since the start of the year.</p>
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			<dc:creator>dewabolanet@gmail.com (Dewa Bola)</dc:creator></item>
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		<title>No, Christine Lagarde doesn’t want to scrap cash for climate</title>
		<link>https://www.bookiebola.club/2024/11/29/no-christine-lagarde-doesnt-want-to-scrap-cash-for-climate/</link>
		
		
		<pubDate>Fri, 29 Nov 2024 03:19:47 +0000</pubDate>
				<category><![CDATA[Green]]></category>
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					<description><![CDATA[A video is being shared on social media which allegedly shows Christine Lagarde, president of the European Central Bank, calling for the abolition of cash in order to reduce our carbon footprint. Christine Lagarde, president of the European Central Bank (ECB) in Frankfurt, is hoping to stop climate change by overhauling the entire economy, including eliminating cash completely, according to claims made in a social media post. Similar posts suggest that the European Central Bank (ECB) is planning to replace cash entirely with a digital euro, which is currently under consideration. One post on X (formerly Twitter) describes this as…]]></description>
										<content:encoded><![CDATA[<p>        A video is being shared on social media which allegedly shows Christine Lagarde, president of the European Central Bank, calling for the abolition of cash in order to reduce our carbon footprint.</p>
<p>Christine Lagarde, president of the European Central Bank (ECB) in Frankfurt, is hoping to stop climate change by overhauling the entire economy, including eliminating cash completely, according to claims made in a social media post.<br />
Similar posts suggest that the European Central Bank (ECB) is planning to replace cash entirely with a digital euro, which is currently under consideration.<br />
One post on X (formerly Twitter) describes this as the biggest &#8220;scam&#8221; on the planet, but in fact, the closest thing to a scam here is what it is claiming.<br />
In the attached video, Lagarde does indeed mention reevaluating the use of banknotes to improve our carbon footprint, but her words have been taken out of context.<br />
She never suggested eliminating cash altogether. Instead, a look at the ECB&#8217;s climate plans, published on its website in early 2024, clarifies that Lagarde was likely referring to efforts aimed at making the financial system more environmentally friendly, rather than phasing out cash altogether.<br />
Instead, a look at the ECB&#8217;s climate plans, posted on its website in early 2024, clarifies what Lagarde was likely referring to.<br />
As part of its 2030 carbon reduction targets, the ECB will work to &#8220;include eco-design principles for the future euro banknote series and incorporate environmental footprint considerations into the design of a digital euro that is currently in the preparation phase&#8221;.<br />
This means the ECB plans to produce banknotes made entirely from organic cotton by 2027, according to the bank&#8217;s climate and nature plan.<br />
Other measures the bank is taking as part of its carbon reduction targets include a deeper analysis of the impact of extreme weather events on inflation and the financial system and looking at how nature loss and degradation affect the economy.<br />
Last December, an ECB study showed that the average environmental footprint of banknote payments was 101 micro points per euro area citizen in 2019.<br />
That&#8217;s the equivalent of driving a car for 8 kilometres, or 0.01% of the total environmental impact of a European’s annual consumption activities, according to the study.<br />
By comparison, producing a cotton T-shirt and washing it once a week for a year is the equivalent of driving 55km, and the amount of manufactured water bottles consumed by a citizen in a year works out at the same as driving 272km, the ECB said.<br />
The main factors contributing to the environmental footprint of banknotes include the energy consumption of ATMs, their transportation, processing by national central banks, paper manufacturing, and the authentication of banknotes in stores.<br />
The ECB has also made clear that it wants to make euro banknotes as environmentally friendly as possible while ensuring cash is widely available and accepted. <br />
There&#8217;s no evidence of it aiming to get rid of cash for good, or fully replace it with the digital euro.<br />
In October 2021, the ECB launched a study phase on the possibility of issuing a central bank digital currency, known as the digital euro, to provide an additional form of public money in the euro area.<br />
In June 2023, the European Commission proposed a legal framework that could pave the way for the ECB to make the digital euro a reality, but the currency is yet to be finalised.<br />
The digital euro would be public money issued by the central bank, unlike bank deposits or cryptocurrencies, which carry financial risk.  It&#8217;s intended to be more of an electronic equivalent of cash rather than something akin to a crypto asset.<br />
EU officials have repeatedly stressed that it would complement, not replace, cash payments.<br />
It would be free to use across the entire eurozone, which is made up of 20 of the EU&#8217;s 27 member states, for everyday expenses like shopping and rent.</p>
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			<dc:creator>dewabolanet@gmail.com (Dewa Bola)</dc:creator></item>
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		<title>Drones hover over three US air force bases in UK – What’s behind the incursion?</title>
		<link>https://www.bookiebola.club/2024/11/25/drones-hover-over-three-us-air-force-bases-in-uk-whats-behind-the-incursion/</link>
		
		
		<pubDate>Mon, 25 Nov 2024 22:30:29 +0000</pubDate>
				<category><![CDATA[News]]></category>
		<guid isPermaLink="false">https://www.bookiebola.club/2024/11/25/drones-hover-over-three-us-air-force-bases-in-uk-whats-behind-the-incursion/</guid>

					<description><![CDATA[The US Air Force reported detecting several small drones last week near three important military bases in eastern England: RAF Lakenheath, RAF Mildenhall, and RAF Feltwell. The drones were observed from Wednesday (November 20) and Friday (November 22). While the Air Force did not disclose the identity of those responsible for the incursions, officials assured that the drones did not impact residents or critical infrastructure. As global hostilities heat up, the US Air Force is stepping up security, but who’s sending these mysterious drones? Royal Air Force Lakenheath, located in Suffolk, is home to the 48th Fighter Wing, a key…]]></description>
										<content:encoded><![CDATA[<p>The US Air Force reported detecting several small drones last week near three important military bases in eastern England: RAF Lakenheath, RAF Mildenhall, and RAF Feltwell. The drones were observed from Wednesday (November 20) and Friday (November 22). While the Air Force did not disclose the identity of those responsible for the incursions, officials assured that the drones did not impact residents or critical infrastructure.<br />
As global hostilities heat up, the US Air Force is stepping up security, but who’s sending these mysterious drones?<br />
Royal Air Force Lakenheath, located in Suffolk, is home to the 48th Fighter Wing, a key component of the US Air Force&#8217;s combat operations in Europe. RAF Mildenhall hosts the 100th Air Refueling Wing, and RAF Feltwell provides housing, schools, and other services. The proximity of these bases has heightened the Air Force&#8217;s vigilance in monitoring airspace and ensuring security. The US Air Force, while not revealing specific countermeasures, emphasized its right to protect these installations.<br />
In a statement, the US Air Forces Europe emphasized that base personnel are working with host-nation authorities and mission partners to ensure the safety of personnel and facilities. The Air Force declined to disclose detailed force protection measures, but reassured that robust security procedures are in place.<br />
The drone sightings occurred during a period of heightened military activity. In a significant escalation of hostilities, Ukraine recently launched intermediate-range missile strikes inside Russian territory, following approval from US President Joe Biden and UK Prime Minister Keir Starmer for the use of these advanced weapons.<br />
In retaliation, Russia launched an intermediate-range ballistic missile at Ukraine, with President Vladimir Putin stating that Russia had the right to strike nations that allow their weapons to be used against Russia.<br />
The UK&#8217;s Ministry of Defense responded to the drone incidents by reaffirming its commitment to security at military installations. It stated that “robust measures” are maintained at military sites, including counter-drone security capabilities. However, it declined to provide further details on specific security procedures.</p>
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			<dc:creator>dewabolanet@gmail.com (Dewa Bola)</dc:creator></item>
		<item>
		<title>US FDA finds widely used asthma drug impacts the brain</title>
		<link>https://www.bookiebola.club/2024/11/22/us-fda-finds-widely-used-asthma-drug-impacts-the-brain/</link>
		
		
		<pubDate>Fri, 22 Nov 2024 17:28:42 +0000</pubDate>
				<category><![CDATA[Latest News]]></category>
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					<description><![CDATA[US government researchers have found that a widely prescribed asthma drug originally sold by Merck &#38; Co may be linked to serious mental health problems for some patients, according to a scientific presentation reviewed by Reuters. The researchers found that the drug, sold under the brand name Singulair and generically as montelukast, attaches to multiple brain receptors critical to psychiatric functioning. Singulair was a blockbuster product for Merck after its launch in 1998, offering relief in a pill as an alternative to an inhaler. In early advertising, the company said the side effects were so benign that they were &#8220;similar…]]></description>
										<content:encoded><![CDATA[<p>US government researchers have found that a widely prescribed asthma drug originally sold by Merck &amp; Co may be linked to serious mental health problems for some patients, according to a scientific presentation reviewed by Reuters.<br />
The researchers found that the drug, sold under the brand name Singulair and generically as montelukast, attaches to multiple brain receptors critical to psychiatric functioning.<br />
Singulair was a blockbuster product for Merck after its launch in 1998, offering relief in a pill as an alternative to an inhaler. In early advertising, the company said the side effects were so benign that they were &#8220;similar to a sugar pill,&#8221; while the label said any distribution in the brain was &#8220;minimal.&#8221; Generic versions are still prescribed to millions of adults and children every year.<br />
But by 2019, thousands of reports of neuropsychiatric episodes, including dozens of suicides, in patients prescribed the drug had piled up on internet forums and in the US Food and Drug Administration’s tracking system. Such “adverse event” reports do not prove a causal link between a medicine and a side effect, but are used by the FDA to determine whether more study of a drug’s risks are warranted.<br />
After years of analysis, the reports and new scientific research led the FDA in 2020 to add a &#8220;black box&#8221; warning to the montelukast prescribing label, flagging serious mental health risks like suicidal thinking or actions. <br />
The agency also convened a group of internal experts around the same time to look into why the drug might trigger neuropsychiatric side effects.<br />
The results of the group&#8217;s work, which are preliminary and have not been previously reported or released publicly, were presented to a limited audience at the American College of Toxicology meeting in Austin, Texas on Wednesday.<br />
Jessica Oliphant, a deputy director at FDA&#8217;s National Center for Toxicological Research, said at the event that laboratory tests showed &#8220;significant binding&#8221; of montelukast to multiple receptors found in the brain. <br />
The FDA also confirmed earlier scientific research showing montelukast penetrates the brains of rats. More study is needed about how the drug accumulates in the nervous system, Oliphant said. &#8220;These data indicate that montelukast is highest in brain regions known to be involved in (psychiatric effects),” she said. <br />
The FDA said it does not plan to update the drug label based on data from the presentation.<br />
The behavior of montelukast appears similar to other drugs known to have neuropsychiatric effects, such as the antipsychotic risperidone, according to FDA slides reviewed by Reuters. The FDA has cautioned that its studies are ongoing, and results have not been finalized.<br />
When the FDA added the black box, it cited research from Julia Marschallinger and Ludwig Aigner at Austria&#8217;s Institute of Molecular Regenerative Medicine.<br />
The two scientists told Reuters on Thursday the new data showed significant quantities of montelukast present in the brain. The receptors involved play a role in governing mood, impulse control, cognition and sleep, among other functions, they said.<br />
The research does not show whether that binding mechanism leads directly to harmful effects in individual patients, or who is particularly at risk, the two scientists said. However, Marschallinger said the new data bolsters reports from people who reported suffering side effects. <br />
&#8220;It&#8217;s definitely doing something that&#8217;s concerning,&#8221; she said. <br />
A Merck representative did not respond to questions. Organon, a Merck spinoff that now markets Singulair, said in a statement it is confident in the drug&#8217;s safety profile. <br />
&#8220;The product label for Singulair contains appropriate information regarding Singulair benefits, risks and reported adverse reactions,&#8221; the company said.<br />
Reuters reported last year that the FDA had received thousands of reports of patients, including many children, experiencing depression, suicidal thoughts and behaviors, or other psychiatric problems after they began using montelukast.<br />
By 2019, the FDA tallied 82 suicides linked to Singulair and its generic versions reported to its adverse-event database since 1998. At least 31 of those reports involved someone age 19 or younger.<br />
Robert England&#8217;s 22-year old son Nick killed himself in 2017 less than two weeks after starting montelukast. England recalls that his son had trouble sleeping before he died, and said he was completely healthy and had no mental health problems prior to taking the drug.<br />
&#8220;He was on that medication for just days, literally just days,&#8221; England said. &#8220;It completely changed the trajectory of our lives.&#8221;<br />
The Reuters report also detailed lawsuits alleging that Merck knew from its early research that the drug could impact the brain and minimized the potential for psychiatric problems in statements to regulators. Many of those lawsuits are still pending.</p>
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			<dc:creator>dewabolanet@gmail.com (Dewa Bola)</dc:creator></item>
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		<title>Adjusting Thyroid Ranges for Age Cuts Hypothyroidism Rates</title>
		<link>https://www.bookiebola.club/2024/11/19/adjusting-thyroid-ranges-for-age-cuts-hypothyroidism-rates/</link>
		
		
		<pubDate>Tue, 19 Nov 2024 08:33:05 +0000</pubDate>
				<category><![CDATA[Pharmacists]]></category>
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					<description><![CDATA[The reference ranges of thyroid-stimulating hormone (TSH) and free thyroxine (FT4), known to vary in children compared with adults, also shift considerably in older age, to the degree that the use of standard ranges in older patients without age adjustment results in significant overdiagnosis and unnecessary treatment for subclinical or overt hypothyroidism, findings from a largest-of-its-kind analysis showed. “Based on our results, we can conclude that implementing age-specific reference intervals in women over 50 years and in men over 60 years would lead to fewer diagnoses of [subclinical] hypothyroidism and less unnecessary levothyroxine prescriptions,” reported the authors in the study…]]></description>
										<content:encoded><![CDATA[<p>The reference ranges of thyroid-stimulating hormone (TSH) and free thyroxine (FT4), known to vary in children compared with adults, also shift considerably in older age, to the degree that the use of standard ranges in older patients without age adjustment results in significant overdiagnosis and unnecessary treatment for subclinical or overt hypothyroidism, findings from a largest-of-its-kind analysis showed.<br />
“Based on our results, we can conclude that implementing age-specific reference intervals in women over 50 years and in men over 60 years would lead to fewer diagnoses of [subclinical] hypothyroidism and less unnecessary levothyroxine prescriptions,” reported the authors in the study published in Thyroid.<br />
Despite evidence showing varying ranges of thyroid hormones TSH and FT4 based on age, few laboratories use age-specific reference intervals other than in childhood, the authors reported.<br />
To take a more comprehensive look and establish TSH and FT4 age-specific reference intervals based on age and determine how the application of those ranges might change the rates of thyroid disease diagnoses, first author Heleen I. Jansen, PhD, of the Department of Laboratory Medicine, Endocrine Laboratory, Amsterdam UMC, Amsterdam, the Netherlands, and colleagues conducted a large, multicenter study, evaluating 7.6 million TSH and 2.2 million FT4 immunoassay results from 13 laboratories in the Netherlands between 2008 and 2022.<br />
The tests were requested for inpatients and outpatients from general practitioners and local hospitals and assessed using four different immunoassay platforms (Roche, Abbott, Siemens, and Beckman Coulter), which were analyzed as four datasets.<br />
Patients were stratified into age groups spanning 2 years in children between the ages of 2 and 18 years.<br />
In adults, a category including ages 18-20 years was evaluated, after which age categories were made for each decade between the ages of 20 and 100.<br />
In children, from ages 2-12 years, upper and lower reference levels of TSH were significantly higher compared with corresponding adult limits, with levels starting to decrease after age 12 and align with adults between 14 and 18 years.<br />
FT4 limits were more stable during childhood, with a slight decrease between ages 12 and 14.<br />
In adulthood, beginning at 60 years, statistically significant increases, overall, in TSH upper reference limits were observed, whereas lower reference levels remained stable until the age of 80, suggesting changes potentially affecting hypothyroidism but not hyperthyroidism.<br />
Among women, the changes were observed earlier, beginning at about the age of 50, whereas for men, they began at about the age of 60.<br />
FT4 upper reference levels were only shown to consistently increase after about age 70.<br />
Impact on Reclassification of Thyroid Disease<br />
To evaluate how the application of age-specific reference intervals could change the rates of diagnosis compared with regular adult reference intervals, the authors applied the ranges to the Roche dataset, including 194,856 women and 85,215 men.<br />
They found that use of the age-specific reference intervals resulted in a decrease in diagnoses of subclinical hypothyroidism from 13.1% to 8.6% in women aged 50-60 years and from 22.7% to just 8.1% for women aged 90-100 years.<br />
Among men, the decreases were from 10.9% to 7.7% for those aged 60-70 years and from 27.4% to 9.6% for those aged 90-100 years.<br />
Differences in diagnoses of overt hypothyroidism were less significant, decreasing from 3.0% to 2.2% among women aged 50-60 years and from 2.8% to 2.3% for women aged 90-100 years, and among men, from 1.7% to 1.4% and 4.0% to 2.9% in the same age categories, respectively.<br />
There were no significant, consistent decreases or increases in subclinical hyperthyroidism patterns.<br />
“Implementation of adult age-specific reference intervals for TSH in clinical practice remains a debated topic,” the authors wrote. “However, our results indicate that age-specific reference intervals, especially for TSH, are clinically significant.” <br />
Levothyroxine in Older Patients<br />
Despite subclinical hypothyroidism known to increase with age, with an estimated 10% prevalence in patients aged 80 years or older, studies, including a large randomized clinical trial, have shown no significant benefit of levothyroxine treatment for subclinical hypothyroidism in patients older than 65 years.<br />
Recommendations for treatment vary, however, with adult hypothyroidism European Thyroid Association guidelines recommending to only consider levothyroxine treatment in adults older than 70 years if TSH concentrations exceed 10 mU/L, as well as in cases of clear symptoms of hypothyroidism or a high risk for vascular disease.<br />
Nevertheless, “levothyroxine is still largely prescribed for older adults with subclinical hypothyroidism without meeting these criteria,” the authors reported.<br />
Based on the results of the new study, for older patients receiving treatment, “levothyroxine can be discontinued in almost a third of its users without consequences for TSH and FT4 results, which was predominantly the case in patients who were diagnosed with subclinical hypothyroidism,” they said.<br />
Further research has in fact shown that a slightly increased TSH may actually be advantageous in adults older than 80 years, suggesting that “the treatment of subclinical hypothyroidism is not beneficial in this group at all,” the authors asserted.<br />
“The take-home message from this is that by implementing age-specific reference ranges for adults, we will have less older persons with subclinical hypothyroidism,” first author Annemieke C. Heijboer, PhD, of the Department of Laboratory Medicine, Endocrine Laboratory, Amsterdam UMC, told Medscape Medical News.<br />
“This leads to less stress for these persons and less work for their physicians, [as well as] less follow-up, without additional health risks as a bit higher TSH only seems to be of an advantage in older persons,” she said.<br />
Method-Specific Reference Ranges Complicate Matters<br />
Heijboer noted that a key challenge in accurately diagnosing hypothyroidism, even with the age-specific reference intervals, is that the ranges can vary based on the specific method used, as indicated by the varying ranges in the four immunoassays included in the study.<br />
“The US guidelines talk about and recommend a higher upper limit of normal for TSH in elderly,” she said. “Unfortunately, they also name exact concentrations, which is problematic, as the different methods used in clinical laboratories are not standardized.”<br />
“So, besides age-specific reference intervals, method-specific reference intervals are highly important,” Heijboer said.<br />
While the study gives age-specific reference intervals for the several frequently used methods, “I hope [new] guidelines will not give these absolute concentrations anymore.”<br />
The differences in the age-specific reference intervals in the study’s four datasets are demonstrated in the study’s supplementary tables.<br />
Adding Granularity to Age Intervals<br />
The study was selected as being among the year’s most important studies in clinical thyroidology in a plenary session at the American Thyroid Association (ATA)’s 2024 Meeting this month.<br />
“The findings really show us how important it is to have age-based reference ranges because [without the age-related adjustments], many patients have the potential to be labeled as having subclinical thyroid dysfunction, when in fact that is probably a normal range for them,” said speaker Jennifer A. Sipos, MD, professor of medicine, Division of Endocrinology, The Ohio State University, Columbus, Ohio.<br />
“Many labs currently use age-based reference ranges; however, [these findings] further cement the importance of that and provide additional granularity on what those intervals need to be and how many ages need to be included in those reference intervals.” <br />
The chance to more appropriately identify patients who can benefit from levothyroxine “is particularly important, as we are hearing more and more about the increased use of prescription of levothyroxine across the United States and potentially among patients who don’t need it, and this poses the potential for complications, especially in our older patients,” Sipos said.<br />
The authors and Sipos had no disclosures to report.<br />
  <br />
Send comments and news tips to news@medscape.net.</p>
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			<dc:creator>dewabolanet@gmail.com (Dewa Bola)</dc:creator></item>
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		<title>Ludhiana: International conference on climate change concludes at PAU</title>
		<link>https://www.bookiebola.club/2024/11/16/ludhiana-international-conference-on-climate-change-concludes-at-pau/</link>
		
		
		<pubDate>Sat, 16 Nov 2024 03:33:16 +0000</pubDate>
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					<description><![CDATA[The four-day international conference on “Transforming Agrifood Systems in the Face of Climate Change and Energy Transitions” concluded at Punjab Agricultural University (PAU) on Friday. The conference, organised by the Indian Ecological Society in collaboration with PAU, saw the participation of national and international delegates. A technical session on “Future Forest Management: Towards Climate Resilience” was also held on Friday. PAU vice-chancellor Satbir Singh Gosal chaired the valedictory function, whereas YS Parmar University of Horticulture and Forestry, Nauni, Solan vice-chancellor Rajeshwar Singh Chandel co-chaired the concluding session. Gosal pointed out the threat being posed by climate change to the entire…]]></description>
										<content:encoded><![CDATA[<p>The four-day international conference on “Transforming Agrifood Systems in the Face of Climate Change and Energy Transitions” concluded at Punjab Agricultural University (PAU) on Friday.<br />
The conference, organised by the Indian Ecological Society in collaboration with PAU, saw the participation of national and international delegates. A technical session on “Future Forest Management: Towards Climate Resilience” was also held on Friday.<br />
PAU vice-chancellor Satbir Singh Gosal chaired the valedictory function, whereas YS Parmar University of Horticulture and Forestry, Nauni, Solan vice-chancellor Rajeshwar Singh Chandel co-chaired the concluding session.<br />
Gosal pointed out the threat being posed by climate change to the entire humanity, thus affecting the global food security and agricultural ecosystems. The degradation of natural resources was equally a serious concern, he observed, while calling for efficient management of natural resources for the preservation of air, soil and water. The PAU V-C hoped that sharing of scientific knowledge during the international conference would help in developing improved farming practices for the sustainability of agrifood systems.<br />
Chandel, while delivering a lecture on “visioning agrifood system pathways through natural farming,” observed that transforming agrifood systems through natural farming addressed environmental, social and economic challenges in modern agriculture. “By prioritising soil health, reducing chemical inputs and enhancing biodiversity, natural farming offers a pathway to a more resilient, sustainable and equitable food systems. Natural farming has shown potential to improve soil health, climate resilience and sustain agrifood systems,” he said.<br />
Speaking on “eco-system services for sustainable agrifood system transformation,” ICAR-National Institute of Agricultural Economics and Policy Research, New Delhi director Dr Kiran Kumar TM said that ecosystem services were the direct and indirect benefits that humans derived from ecological system. Agriculture offered a wide range of ecosystem services including provisioning services such as food, feed, fibre and fuel; regulating services such as pollination, pest control, insect-disease management, and climate regulation; supporting services like soil fertility maintenance, biodiversity conservation and nutrient cycling; and cultural services encompassing spiritual, aesthetic and recreational activities, he added.<br />
PAU entomology department head Manmeet Brar Bhullar proposed a vote of thanks and lauded the successful culmination of the four-day international conference. </p>
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			<dc:creator>dewabolanet@gmail.com (Dewa Bola)</dc:creator></item>
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		<title>Donald Trump has promised a closed border and mass deportations. Those affected are taking action now</title>
		<link>https://www.bookiebola.club/2024/11/12/donald-trump-has-promised-a-closed-border-and-mass-deportations-those-affected-are-taking-action-now/</link>
		
		
		<pubDate>Tue, 12 Nov 2024 17:28:35 +0000</pubDate>
				<category><![CDATA[US]]></category>
		<guid isPermaLink="false">https://www.bookiebola.club/2024/11/12/donald-trump-has-promised-a-closed-border-and-mass-deportations-those-affected-are-taking-action-now/</guid>

					<description><![CDATA[Immigrants, their employers and groups that work with them are already taking action ahead of President-elect Donald Trump’s second term, in which he has promised to deport millions of people. Some fear how the new administration could impact their families, while others are hopeful the plans — if they materialize — will make things better. Trump allies are discussing deportation and detention options, with tackling the US-Mexico border seen as a priority from Day 1. And removing undocumented immigrants who have committed crimes is likely to be an early focus, a source familiar with the team’s preliminary plans told CNN.…]]></description>
										<content:encoded><![CDATA[<p>            Immigrants, their employers and groups that work with them are already taking action ahead of President-elect Donald Trump’s second term, in which he has promised to deport millions of people.</p>
<p>            Some fear how the new administration could impact their families, while others are hopeful the plans — if they materialize — will make things better.</p>
<p>            Trump allies are discussing deportation and detention options, with tackling the US-Mexico border seen as a priority from Day 1. And removing undocumented immigrants who have committed crimes is likely to be an early focus, a source familiar with the team’s preliminary plans told CNN.</p>
<p>            But advocates fear deportation plans will soon reach deeper into American communities, targeting people who they say have a right to live here.</p>
<p>            The League of United Latin American Citizens, the oldest Hispanic civil rights organization in the United States, is securing money and lawyers to fight what it is already calling potential “vicious, malevolent, cruel and ruthless” immigration policies.</p>
<p>            “Make no mistake: Mass deportations will harm the millions targeted by Donald Trump, the families and communities they are part of — and every person in our country. They will rip parents from their children, destroy businesses and livelihoods, and devastate the fabric of our nation and our economy,” said Juan Proaño, CEO of LULAC.</p>
<p>            A lawyer with the American Civil Liberties Union says its planning for legal challenges is already well advanced.</p>
<p>            “We have been preparing for a second Trump term for nearly a year, with a focus on the most draconian possible policies, including the threat to use the military for deportation, which is flatly illegal,” said Lee Gelernt, an ACLU attorney who argued many of the most high-profile cases during Trump’s first term.</p>
<p>            The National Immigrant Justice Center said its lawyers were ready, too.</p>
<p>            “We will continue our work of providing critical legal representation to immigrants and refugees, fighting to keep families together, defending access to asylum, and advocating for the end of arbitrary detention and unjust deportation,” Mary Meg McCarthy, the center’s executive director, said in a statement.</p>
<p>            Cesar Espinosa, a leader in Houston’s Hispanic community, said he’s had many calls and messages from worried people since Trump won reelection early Wednesday.</p>
<p>            “We can feel the sense of uncertainty from a lot of people. A lot of people are asking, ‘What happens now? What do we do?’” he said.</p>
<p>            Some are in so-called mixed status families made up of US citizens and undocumented immigrants. And the fear is that non citizens will be targeted immediately, said Espinosa, who is a legal permanent resident, or “green card” holder.</p>
<p>            He says he tries to calm fears by saying that mass deportations, particularly of non-criminals, will take time. Meanwhile, he keeps count of the time when he can apply for US naturalization, still more than two years away.</p>
<p>            Espinosa said machismo among Latino men may have contributed to support for Trump.</p>
<p>            “Unfortunately, a lot of people in the Latino community have bought into the rhetoric of being anti-immigrant, even the immigrants themselves,” he said.</p>
<p>            Jorge Rivas’ support for Trump is obvious. He features a MAGA burger on the menu at Sammy’s Mexican Grill, in Catalina, Arizona, north of Tucson, the restaurant he runs with his wife, Betty.</p>
<p>            Rivas, born in El Salvador, was granted asylum at age 17, he says, and sees little connection between his life as an immigrant and those at the top of Trump’s potential deportation list.</p>
<p>            “If they let in hundreds or thousands of people who already have criminal records, if deporting them creates a mass deportation, I’m all for it,” he said.</p>
<p>            He does not think the action will extend to law-abiding workers.</p>
<p>            “That wouldn’t be fair,” he said.  “They need to make sure that they don’t throw away, they don’t kick out, they don’t deport people that are family oriented.”</p>
<p>            In California, where farmers are reliant on migrant labor, there is a renewed call for immigration reform to allow people into the US for temporary agricultural work. There are also calls for legal status for the current workforce.</p>
<p>            “We must focus on easing the chronic employee shortages on California farms and ranches and reducing the barriers to employment,” California Farm Bureau President Shannon Douglass said in a statement to CNN.</p>
<p>            In the urban heart of New York City, where thousands of migrants and asylum seekers have stretched local resources, some houses of worship are preparing to shift their missions.</p>
<p>            “The faith community has been mobilized for more than two and a half years in kind of an emergency capacity,” said the Rev. Chloe Breyer, executive director of the Interfaith Center of New York, a religiously diverse non-profit agency. “The challenge was not specifically deportation, as it is now, the challenge was the feeding, the housing and the welcome of enormous numbers of people.”</p>
<p>            She said there was a biweekly call of about 60 churches, mosques and synagogues involved in welcoming migrants that could be pivoted. “That’s the network that will be mobilized when it comes to fighting any sort of more extreme measures such as deportation.”</p>
<p>            A day after the election, New York City officials said fear was premature when they addressed immigration and how they would work with the incoming Trump administration.</p>
<p>            The city has sanctuary laws that prevent local authorities from contacting federal immigration officers if they come across a migrant without permission to be in the US. Some in Mayor Eric Adams’ administration have said they want the laws amended to not include those who commit violent crimes, but for now any city-federal cooperation is limited.</p>
<p>            “We’re working with all of the agencies that interact with immigrant communities to make sure that they understand what our sanctuary laws are and what they are expected to follow,” said Manuel Castro, the mayor’s commissioner for immigrant affairs. While the laws are in place, he said, anxiety and fear for immigrant communities is rooted in misinformation and even hate crimes.</p>
<p>            But Murad Awawdeh, president of the New York Immigration Coalition, warned that sanctuary laws won’t stop federal immigration agencies from doing what they want.</p>
<p>            “Sanctuary laws don’t stop federal agencies. They just don’t allow the city and state to participate,” Awawdeh said. “They’ve never been a firewall.”</p>
<p>            Officials in US Customs and Border Protection and US Immigration and Customs Enforcement, two agencies under the Department of Homeland Security, are not commenting on any potential new policies or preparations. Both would be central to any deportation plan, but top leadership will not change until the second Trump administration begins its work on January 20.</p>
<p>            At both the northern and southern borders, apprehensions of those who have crossed illegally continue to be low in 2024, with a seven-day average of 1,700 a day, according to a law enforcement source familiar with the government data. The busiest sector was San Diego, with 350 people detained on Tuesday.</p>
<p>            At some points in December 2023, migrant apprehensions exceeded 10,000 per day on the US southern border.</p>
<p>            The day after the election, Jim Desmond, a member of the San Diego County Board of Supervisors, posted a picture of himself and Vice President-elect JD Vance at the border wall, saying he was looking forward to securing it. Earlier this year, Desmond testified before Congress that federal policies had meant “our Border Patrol has been reduced to processing agents, standing by, watching people break our laws.”</p>
<p>            Kenia Zamarripa, of the San Diego Regional Chamber of Commerce, said many local businesses had ties across the border with companies, operations and workers and that an efficient and secure border should still facilitate trade and travel.</p>
<p>            “It’s not just manufacturing, it’s not just tourism or retail, these are high-paying jobs and skilled workers that our businesses need to thrive,” she told CNN.</p>
<p>            The tone was more defiant in Los Angeles, where the University of Southern California estimated last year there were more than 800,000 undocumented immigrants in LA county. Los Angeles Mayor Karen Bass told CNN: “The immigrant community is the heart of our city and in the face of threats and fear, Los Angeles will stand together. No one should live in fear due to their immigration status. We will continue to support local and state policies that protect immigrants and provide vital resources.”</p>
<p>            She added: “My message is simple: No matter where you were born, how you came to this country, Los Angeles will stand with you and this will not change.”</p>
<p>            The Los Angeles Unified School District — the second largest in the nation behind New York City — said it was bracing for a potential threat of legal action against students and their families that could lead to separation or deportation. It added that it would not enter into agreements with government agencies for the enforcement of federal immigration law unless required by law.</p>
<p>            “Immigration enforcement activities around schools create hardships and barriers to health and educational attainment and cultivate a pervasive climate of fear, conflict, and stress that affects all students in our district, regardless of their background or immigration status,” a spokesperson for the district said in a statement sent to CNN.</p>
<p>            Across the border from San Diego in Tijuana, Mexico, about 3,400 people are waiting in migrant shelters, according to Jose Luis Perez Canchola, the city’s migration affairs director.</p>
<p>            Many are hoping to enter the US legally using the CBP ONE app run by DHS to get an immigration appointment, but there are fears that the app could be impacted, he said.</p>
<p>            “In the event of a mass cancellation of appointments and closing CBP ONE, what may happen is that many will decide to illegally cross the border before January 2025,” Perez Canchola said.</p>
<p>            There is also concern in Piedras Negras, the Mexican city across the Rio Grande from Eagle Pass, Texas. “There’s fear and trepidation,” said Sister Isabel Turcios, director of the Frontera Digna shelter, where migrants were also using CBP ONE to get an appointment with an immigration officer.</p>
<p>            “I try to calm them because the anxiety they’re feeling is very great,” she said.</p>
<p>            CNN’s Priscilla Alvarez contributed to this story.</p>
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			<dc:creator>dewabolanet@gmail.com (Dewa Bola)</dc:creator></item>
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		<title>Ireland v New Zealand live updates: Autumn Nations Series</title>
		<link>https://www.bookiebola.club/2024/11/09/ireland-v-new-zealand-live-updates-autumn-nations-series/</link>
		
		
		<pubDate>Sat, 09 Nov 2024 08:35:24 +0000</pubDate>
				<category><![CDATA[Latest]]></category>
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					<description><![CDATA[5 mins: After the scrum, Ireland knock on after a sloppy pass, the rain lashing down and it’s a scrum to New Zealand. Ireland 0 New Zealand 0 2 mins: Great block down from Andrew Porter from a box kick leads to a knock on, the crowd loved that one. Early attacking scrum for Ireland. Ireland 0 New Zealand 0 Time for the haka and the national anthems. The haka in all its glory as rain comes down in the Aviva. Ireland inch their way forward as it concludes. A reminder of the teams, kick-off at 8.10pm. IRELAND: Hugo Keenan; Mack…]]></description>
										<content:encoded><![CDATA[<p>5 mins: After the scrum, Ireland knock on after a sloppy pass, the rain lashing down and it’s a scrum to New Zealand.<br />
Ireland 0 New Zealand 0<br />
2 mins: Great block down from Andrew Porter from a box kick leads to a knock on, the crowd loved that one. Early attacking scrum for Ireland.<br />
Ireland 0 New Zealand 0<br />
Time for the haka and the national anthems. The haka in all its glory as rain comes down in the Aviva. Ireland inch their way forward as it concludes.<br />
A reminder of the teams, kick-off at 8.10pm.<br />
IRELAND: Hugo Keenan; Mack Hansen, Garry Ringrose, Bundee Aki, James Lowe; Jack Crowley, Jamison Gibson-Park; Andrew Porter, Rónan Kelleher, Finlay Bealham; Joe McCarthy, James Ryan; Tadhg Beirne, Josh van der Flier, Caelan Doris (capt). Replacements: Rob Herring, Cian Healy, Tom O’Toole, Iain Henderson, Peter O’Mahony, Conor Murray, Ciarán Frawley, Jamie Osborne.<br />
NEW ZEALAND: Will Jordan; Mark Tele’a, Rieko Ioane, Jordie Barrett, Caleb Clarke; Damian McKenzie, Cortez Ratima; Tamaiti Williams, Asafo Aumua, Tyrel Lomax, Scott Barrett, Tupou Vaa’i, Wallace Sititi, Sam Cane, Ardie Savea. Replacements: George Bell, Ofa Tu’ungafasi, Pasilio Tosi, Patrick Tuipulotu, Samipeni Finau, Cam Roigard , Anton Lienert-Brown, Stephen Perofeta.<br />
Referee: Nic Berry (Australia).<br />
Gordon D’Arcy has his say in his column this week, remembering playing the All Blacks in his day.<br />
“In November 2005, Ireland played New Zealand in the old Lansdowne Road. It was my first time playing the All Blacks, so I was a ball of nerves and excitement.<br />
“My opposite number on that day, Ma’a Nonu, would also bookend my career, opposing me in my last outing, a narrow loss to the Kiwis in the Aviva Stadium in 2013.”<br />
[ Gordon D’Arcy: The haka needs to be answered or else it becomes one-sided pageantryOpens in new window ]<br />
The Caelan Doris era begins in earnest against All Blacks at the Aviva, writes Gerry Thornley, as the captain’s leadership will be based foremost on his own deeds. “Probably actions first,” Doris said, when asked about his leadership style, adding: “I think I’ve a good relationship with all of the individuals within the group.”<br />
[ Caelan Doris’s era as Irish rugby captain begins in earnest against All Blacks at the AvivaOpens in new window ]<br />
But he comes up against an almighty opponent tonight in Ardie Savea. Who will come out on top? John O’Sullivan examines the question:<br />
[ Caelan Doris v Ardie Savea: Who will come out on top at the Aviva?Opens in new window ]<br />
Rugby’s ‘favourite grudge match’ was not always this way, writes Gerry Thornley about the Ireland-All Blacks rivalry.<br />
It seems fitting that the latest instalment between Ireland and New Zealand has a night all to itself next Friday. Even on the official Six Nations website they are moved to ask if this is rugby’s favourite grudge match. If so, it wasn’t always thus. It was not much of a rivalry, never mind one tinged with any kind of grudge.<br />
How could it be when one side never won in 28 attempts going back over 111 years?<br />
[ Ireland v New Zealand rivalry: Rugby’s ‘favourite grudge match’ was not always this wayOpens in new window ]<br />
Overall head-to-head: Played 37, Ireland 5 wins, 1 drawn, New Zealand 31 wins.<br />
Last five meetings — 2023: New Zealand 28 Ireland 24 (Paris, RWC q/f); 2022: New Zealand 22 Ireland 32 (Wellington); 2022: New Zealand 12 Ireland 23 (Dunedin); 2022: New Zealand 42 Ireland 19 (Auckland); 2021: Ireland 29 New Zealand 20 (Dublin).<br />
Betting: 2-5 Ireland, 19-1 Draw, 2-1 New Zealand. Handicap odds (New Zealand +6 pts): 10-11 Ireland, 20-1 draw, 10-11 New Zealand.<br />
Nathan Johns looks behind the numbers at five areas where Ireland can target the All Blacks tonight in his stats piece. Ireland discovered to their cost in the World Cup quarter-final that small margins can make all the difference when it comes to prevailing over New Zealand. Check them out here:<br />
[ Behind the numbers: Five areas where Ireland can target the All BlacksOpens in new window ]<br />
Fresh off the presses, here is Gerry Thornley’s Counter Ruck newsletter, where he tries to analyse what went wrong for Ireland last time they played the All Blacks and focuses on the set-piece. A big night for James Ryan is needed at the Aviva:<br />
[ Gerry Thornley: Set-piece will be crucial if Ireland are to beat All BlacksOpens in new window ]<br />
If you’re on the way home from work, or even better, on the way to the pub or a pal’s house to watch it, check out the last Counter Ruck podcasts on the New Zealand game including some great anecdotes from Gordon D’Arcy:<br />
Hello and welcome to live coverage of Ireland’s match against New Zealand, the first of Ireland’s Autumn Nations Series games. Ireland last met the All Blacks in the 2023 Rugby World Cup quarter-final, suffering a 28-24 defeat, so there is a chance for revenge here, even if it’s not the level of the World Cup. Test matches against the All Blacks have been rip-roaring affairs in recent years as the rivalry has intensified, and new captain Caelan Doris leads out Ireland for the toughest of four Test games against southern hemisphere opposition. Kick-off from the Aviva Stadium is at 8.10pm. Here are the teams and the officials for tonight’s game:<br />
IRELAND: Hugo Keenan (Leinster); Mack Hansen (Connacht), Garry Ringrose (Leinster), Bundee Aki (Connacht), James Lowe (Leinster); Jack Crowley (Munster), Jamison Gibson-Park (Leinster); Andrew Porter (Leinster), Rónan Kelleher (Leinster), Finlay Bealham (Connacht); Joe McCarthy (Leinster), James Ryan (Leinster); Tadhg Beirne (Munster), Josh van der Flier (Leinster), Caelan Doris (Leinster, capt).<br />
Replacements: Rob Herring (Ulster), Cian Healy (Leinster), Tom O’Toole (Ulster), Iain Henderson (Ulster), Peter O’Mahony (Munster), Conor Murray (Munster), Ciarán Frawley (Leinster), Jamie Osborne (Leinster).<br />
NEW ZEALAND: Will Jordan (Crusaders); Mark Tele’a (Blues), Rieko Ioane (Blues), Jordie Barrett (Hurricanes), Caleb Clarke (Blues); Damian McKenzie (Chiefs), Cortez Ratima (Chiefs); Tamaiti Williams (Crusaders), Asafo Aumua (Hurricanes), Tyrel Lomax (Hurricanes), Scott Barrett (Crusaders, capt), Tupou Vaa’i (Chiefs), Wallace Sititi (Chiefs), Sam Cane (Chiefs), Ardie Savea (Moana Pasifika).<br />
Replacements: George Bell (Crusaders), Ofa Tu’ungafasi (Blues), Pasilio Tosi (Hurricanes), Patrick Tuipulotu (Blues), Samipeni Finau (Chiefs), Cam Roigard (Hurricanes), Anton Lienert-Brown (Chiefs), Stephen Perofeta (Blues).<br />
Referee: Nic Berry (Australia).<br />
Assistant referees: Karl Dickson (England), Andrea Piardi (Italy).<br />
TMO: Brett Cronan (Australia).</p>
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			<dc:creator>dewabolanet@gmail.com (Dewa Bola)</dc:creator></item>
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