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Diabetes

2013-08-03T23:49:00.001-07:00

Diabetes

With the social development and improvement of people's living standard, diabetes has become a global disease, is now a serious third after cardiovascular disease and cancer. Diabetes is caused by a lack of insulin secretion or insulin resistance caused by a group of metabolic diseases characterized by chronic hyperglycemia fat carbohydrate-related, and protein metabolism disorders, chronic high blood sugar can lead to dysfunction or failure of the various tissues and organs, especially the eyes, kidneys, nerves and cause damage to blood vessels. Diabetes is divided into type 1 diabetes, type 2 diabetes, gestational diabetes, and other specific types of diabetes.
Mechanisms of stem cell therapy for diabetes

Stem cells are a class of pluripotent cells with the ability to replicate themselves, after the damaged human organs, active stem cells can migrate to damaged organs and differentiate into cells that play a role in repair and regeneration of tissues and organs, the medical profession is called "cell wildcard ". Stem cell transplantation for the treatment of diabetes, based on the unique biological characteristics of stem cells, the ability of strong self-renewal and differentiation potential, so the best seed islet β cells (insulin secretion by pancreatic β cells), increasing the number of pancreatic β cell function to prevent decline pancreatic β cells, as much as possible to save and restore the function of the pancreas.
How stem cells change the function of the pancreas?

Experts Modern Hospital Guangzhou (Stem Cell Research & Treatment Center) said, showed that the stem cells in the treatment of diabetes is not a substitute for simple cells, but through five steps to change the function of the pancreas?

The first step: activate the patient's own islet cells. Stem cell after the intervention, in a very short time a large number of islet cells was activated, its function is restored.

Step 2: Fix the β cell island. Insulin-secreting pancreatic β cells in vivo primary cells. Stem cells have the function of secreting insulin for repair through direct β-cells, and to stimulate the regeneration of pancreatic β cells.

Step 3: stem cells improve insulin secretion cells of the human body other. In the human body, in addition to β-cells that secrete insulin, as well as in other organs and tissues inside the body there are some cells that can secrete insulin. Repair and regeneration of cells by stem cell can increase the secretion of insulin in the body, which may play a role in lowering blood sugar.

Step 4: stem cells play a role in insulin resistance. Improve islet receptor and bind insulin, and reduce the role of insulin resistance.

Step 5: increase the body's own insulin secretion rate. Stem cells can grow pembelahannya in one cycle, the new cells will be increased gradually, to replace the islet cells which aging occurs, at the same time to open a new cycle of metabolism, comprehensive care for diabetes.
Stem cell transplant process:

After collecting colony stimulating factor mobilization of bone marrow stem cell separation → → developed and expanded stem cells directed intervention → pancreas transplantation.
Stem cells in the treatment of diabetes

Transplantation methods commonly used in the treatment of diabetes: transplantation of autologous bone marrow stem cells, blood stem cell transplantation, transplantation of human embryonic stem cells, transplantation of umbilical cord blood stem cells, umbilical cord stem cell transplant mesenchymal

1. Transplantation of autologous bone marrow stem cells: bone marrow of patients with diabetes taking itself, in vitro after the induction drugs, bone marrow stem cells are targeted and directed, so as to differentiate into insulin-producing cells, then the number is increasing, and then injected into the patient to treat diabetes .

2. Blood stem cell transplantation: is the use of blood component separation technology, stem cells of bone marrow is concentrated together in the patient himself, spread in vitro with the help of medicine, stem cell DNA repaired, modified, strengthened, renewed and transformed, and make gene reorganization in insulin-secreting cells, and then by the threat of flu virus carrier input to the appropriate organs of the body of the patient.

3. Transplantation of human embryonic stem cells: embryonic stem cells are isolated in the embryo sac, and the orientation induced to differentiate into cells that can produce insulin and can then be issued, and then transferred to the affected part, will be able to repair the damaged islet tissue, so it can cure diabetes. Embryonic stem cell transplantation has an advantage with low immunogenicity, lower rejection response to light and so on.

4. Transplantation of umbilical cord blood stem cells: umbilical cord blood stem cells have the ability to regenerate, regenerative ability is 10 to 20 times the capacity of bone marrow. Cord blood taken can be developed and targeted, which differentiate into various tissue cells to treat diseases such as diabetes.

5. Transplantation of umbilical cord mesenchymal stem cells: umbilical cord conventional care after the baby is born, collecting umbilical cord, the separation of fresh stem cells, cultivated in the laboratory, above a certain level is inserted in a patient.

What are the advantages of stem cells to treat diabetes?

The emergence of high-tech stem cell to break through the barriers of traditional medicine. Most diseases rooted in cellular damage, stem cell differentiation through specific cells to replace damaged cells in the body, so as to achieve the purpose of reconstruction. What are the benefits of stem cell therapy for diabetes?

1, stem cell therapy for diabetes has a very significant effect. After intravenous injection of stem cells or the intervention into the patient's body to repair damaged cells in the body, stem cells have the ability of self-replication and differentiation, in order to achieve the reconstruction goals bodily functions.

2, stem cell therapy is a form of cell biological therapy, no significant effect on the patient's body. So far, stem cells in the treatment does not cause significant side effects or adverse reactions.

3, the prevalence of stem cells in the blood, bone marrow or peripheral blood human placenta, has the advantage of being easy to obtain, because the stem cells are taken from the body, giving back to the body, so there is no rejection.
Stem cells bring hope for diabetics

Stem cell therapy is a form of cell biology, is an advanced medical technology to break through the barriers of traditional treatment brings hope for diabetes treatment.

With stem cells from the patient's body, which can make normal islet cells, a new generation of islet cell insulin secretion can achieve, without the need for drugs and insulin therapy, to help patients get rid of dependence on insulin and medications. .

Compared with traditional medicine, stem cell treatment highlights the advantages of biotechnology disease.

Opportunity Recovery Treatment

2013-08-03T23:39:00.001-07:00

Opportunity Recovery Treatment

Stem cell treatment to treat diabetes is the most sophisticated and effective. According to the American Medical Association published a research report: stem cell experiments conducted on 15 patients with diabetes, 13 patients need to get rid of dependence on insulin, without taking any other medicines, rehabilitation rate of 86%, the remaining 2 diabetic patients with polydipsia, polyuria, polyphagia, symptoms weight loss has been reduced, a significant reduction of insulin injections.

2 diabetic patients after stem cells in the treatment of neonatal islet cells can play like normal islet cells, blood glucose and glycosylated hemoglobin reduced to the normal range. After a week after the normal activities resume a normal life, without deliberate control diet, do not worry about the risk of glucose. 5 years after surgery found no signs of recurrence and pain.

Stem cells in the treatment of diabetes, today is one of the more effective treatments. It seems a lot of people with diabetes see hope for a cure.

diagnosis of diabetes

2013-08-03T23:36:00.003-07:00

diagnosis of diabetes

Diabetes is a blood sugar as the main feature of systemic metabolic disorders. Under normal circumstances, the body's blood glucose level is maintained within a stable range (3.9 to 6.0 mmol / l), which is mainly caused by the insulin regulation. Diabetes, a sufficient amount of insulin in the body, or the role of defects, increased blood sugar naturally. Useful for the early diagnosis of diabetes early treatment at baseline, end of treatment delay in diagnosis greater risk, diagnosis of diabetes can not be wrong, and can not be missed, every adult, especially the more than 40-year adult should be aware of the correct diagnosis of diabetes, it is can greatly reduce the risk of diabetes complications.

Regardless of symptoms or complications, the key is to first take into account the possibility of this disease and urine, blood sugar checks, which will be confirmed.

(A) in view of diabetic urine sugar test results must consider the following situation. Results of urine glucose measurements for diagnostic reference only, and diagnosed diabetes need to rely on the measurement of blood glucose.

(1) If a small amount or trace glucosuria, and unintentional in patients after a glucose tolerance test on eating should be done to see if the positive test results.

(2) clinically suspected symptoms of diabetes, urine sugar repeatedly negative, should pay attention to the determination of blood glucose fasting and 2 hours after eating.

(B) blood sugar glucose is used three methods: venous plasma glucose (VPG), the overall capillary blood glucose (CBG) and venous whole blood glucose (VBG), in which two of the most commonly used.

(C) glucose tolerance test, fasting normal or slightly higher patient occasional glycosuria or diabetes patients suspected (if positive family history, or recurrent miscarriage, premature birth, infant mortality, macrosomia, dystocia, abortion mother, or repeatedly make carbuncle furuncle ), glucose tolerance test. Fasting blood was significantly higher dominant severe cases the diagnosis has been able to determine a large amount of glucose can aggravate the burden should be exemption.

People with diabetes do not know he was ill, was diagnosed with diabetes, usually over 7-10 years or higher, many patients complications, they know that they have had a few years ago, diabetes. Therefore, a correct understanding of the diagnosis of diabetes, annual medical examinations, and conducive to the prevention and early detection of disease.

causes of diabetes

2013-08-03T23:34:00.002-07:00

causes of diabetes

Diabetes is can occur at any age, of any age will suffer from an illness, many people do not know the cause of diabetes diabetes. Diabetes is generally in our daily lives is very difficult to avoid, after suffering from the disease, causing great stress on the patient's heart. Diabetes at a later stage they will threaten the lives and safety of patients, causes of diabetes, we should be more understanding.
1. dietary factors

Nutritional balance of the food, but the first level of caloric intake should be in accordance with the principles of healthy people who actually have to follow the principles of diet, healthy people own ability to regulate blood sugar, diabetes or diabetes-prone population does not have this capability. So as excessive sweets, overeating, high-fat foods, excessive consumption of food, which is triggered by the important reasons for poor control and diabetes.

2. long-term stress

The rhythm of modern social life gradually accelerated during learning and work pressure, tension can cause long-term stress, high pressure will cause diabetes.
3. drug

After drug treatment, is relatively easy to cause electrolyte disturbances patient's body, and thus will gradually cause disease.
4. gestation

Gestational orange anti-insulin hormones such as prolactin, growth hormone, estrogen, progesterone, increased secretion of adrenal hormones, in addition, the placenta can produce insulin enzyme accelerates the degradation of insulin.
5. Surgery and major trauma

Trauma of major surgery, anesthesia, and patients, who experience stress factor machine, adrenal corticosteroid secretion and sugar can be improved, so that the blood sugar, diabetes-prone population can lead to diabetes, stress normal population can return to normal after glucose back.
6. autoimmune

If you have a cold, fever and other symptoms of illness should be treated immediately when immunity is low, easily penetrated by the virus and thus suffer from this disease, and serious damage to the islet B cells.
7. obesity

Obesity is one of the main causes of the sugar, the disease is high blood pressure, reduce insulin B-cell function run easily lead to type 2 diabetes due to obesity.

Expert Modern Hospital Guangzhou (Stem Cell Research & Treatment Center) said, If you are suffering from diseases due to diabetes, do not be surprised, we must do the examination to find causation. Pathogenic factor type 1 diabetes have a family relationship with the pathogenic factors of type 2 diabetes is associated with daily living habits. The prevalence of type 2 diabetes may be too much good food, too little moving, serious emotional without integral rule.

symptoms of diabetes

2013-08-03T23:32:00.002-07:00

symptoms of diabetes

Diabetes is a very common disease, and diabetes in the world has more than 250 million. In many diseases, the disease is more than a strand of hair disease, and in serious cases can lead to people with disabilities or death, so that diabetes requires early detection and early treatment. what are the symptoms of diabetes? We worked together to figure out.

1. frequent urination. The higher the blood glucose, urinary glucose excretion urinate more and more. However, the elderly and people with kidney disease, increased blood sugar with mild to moderate increases urine is not clear.

2. drink more water. Causes of excessive water loss, cell dehydration occurs, the central nervous system to stimulate thirst, causing thirst and polydipsia. Polydipsia is aggravated.

3. Eating more. Tissue of patients with diabetes are often in a "state of hunger", so as to stimulate the central nervous system of eating, causing hunger, more food, in addition, the body can not make full use of glucose, a large amount of glucose excretion, so that the body is actually in a semi- hunger, lack of energy also cause loss of appetite hyperactivity.

4. weight loss. Diabetes appetite and food intake to normal, or even increased, but the weight loss.

5. Fatigue. Is common in patients with diabetes, glucose can not be completely oxidized, and thus feel unwell, lethargy.

6. Decreased vision. Number of diabetic patients in the early treatment complained of decreased or blurred vision. Most common early functional changes, excellent glycemic control, vision returned to normal more quickly.

7. Complications. Many complications of diabetes, diabetic skin infections, diabetic foot, diabetic gastroparesis, diabetic cardiomyopathy, diabetes, heart disease, diabetes and high blood pressure, diabetes, kidney disease, diabetes complicated by urinary tract infections, etc..

Most people with diabetes are found in the examination, then lost the best treatment time. Modern Asian stem cell research and treatment center to tell us, not clinical diabetes at baseline, the end, but years of clinical experience indicates that, stem cell transplantation in the early stages of diabetes, treatment of diabetes prevention is the best time for any type of complication.

Diabetes is common sense understanding of the above, I believe that the understanding of diabetes with updates, and diabetes in a relatively high incidence of clinical disease in recent years, in which experts have warned that the lives of patients with symptoms of diabetes to the hospital to confirm the diagnosis and treatment .

What is diabetes?

2013-08-03T23:30:00.001-07:00

What is diabetes?

Diabetes is due to insufficient insulin secretion or cell metabolic syndrome caused by defective insulin protein glucose, and lipid metabolism disorders. Characterized by an abnormal concentration of glucose in the blood circulation and positive urine. If high blood sugar can experience the typical symptoms of hyperglycemia, polydipsia, polyuria, polyphagia and weight loss, and is accompanied by fatigue, weakness. In patients with severe, susceptible to various infections. With the long course of the disease, metabolic disorders can lead to chronic complications of the eyes, kidneys, nerves, blood vessels and heart tissue and other organs.
What are the types of diabetes?

In accordance with the recommendations of the expert group of the World Health Organization (WHO) and International Diabetes Federation (IDF), diabetes can be divided into types type 1, type 2, and other special types and gestational diabetes. Where type 1 and type 2 is the most important of the two types of

Type 1 diabetes, also called insulin-dependent diabetes, usually occurs in children younger than 30 years old young people, because the β-cells are damaged, so the lack of insulin secretion, complementary needs for life dependent on exogenous insulin for survival.

Type 2 diabetes called diabetes mellitus non-insulin-dependent, occurs in more than 40 years, secretion, insulin elderly low not even a high clinical manifestations of the body is not sufficiently sensitive to insulin, ie insulin resistance (insulin resistance, IR). In patients with diabetes, approximately 95% of the proportion of type 2 diabetes.

Gestational diabetes is diabetes occurs during pregnancy. Pregnancy, mother and produce large amounts of various hormones. These hormones are very important for the healthy growth of the fetus, but they can also block the role of maternal insulin, causing insulin resistance, leading to maternal hyperglycemia.

Other specific types of diabetes is not a type 1 or type 2 diabetes, which is associated with gestational diabetes, including diabetes caused by pancreatic disease or endocrine disease, drug-induced diabetes and genetic diseases associated with diabetes. Other specific types of diabetes, although complex etiology, but accounted for less than 1% of the total number of patients with diabetes. Among them, some types of diabetes are the major drug-disease remission
Diabetes can be a killer all public health

A recent study showed that over the last 30 years of the adult population in the world with nearly 350 million people have diabetes, and diabetes is no longer a "disease of the rich", but has become a global problem. The researchers warn that diabetes may threaten global health 10 years into the future.
Incident Diabetes Population

Harvard's longest and largest study in the world of epidemiology, people in Asia after the age of 18 years, any weight increased 5 kg, 2-fold increased risk of diabetes, the rate is much higher than blacks and Caucasians.

Medical staff warned, Asian, black and Latino groups are prone to diabetes population, therefore, should strengthen prevention. Some Asian body fat is more likely to accumulate in the stomach or a "dangerous position" other, produce an effect on appetite hormones, so people who are already overweight, eat more, and thus increase the risk of diabetes.
Dangers of diabetes

Although diabetes is familiar, but awareness of the dangers still not enough!

Uremia, blindness, non-traumatic amputations are caused by diabetes on the citizens of Europe and the United States, in recent years, the survey showed that three quarters of coronary heart disease and high blood sugar, and nearly half of patients with cerebrovascular diabetes. Number of findings of the survey in the hospital, more than half of diagnosed diabetes complications of neuropathy, it was found that patients at risk of developing diabetes digestive system tumors, significantly increases the risk of breast tumors. Over time, serious diabetes complications in the future will become more and more again. Therefore, diabetes and other chronic disease prevention and control has become a major public health problem in this country.

Surgical treatment of endometriosis

2013-07-27T22:02:00.000-07:00

Surgical treatment of endometriosis

Surgical treatment for endometriosis can be useful when the symptoms of endometriosis are severe or when there has been an inadequate response to medical treatment. Surgery is the preferred treatment when there is anatomic distortion of the pelvic organs or obstruction of the bowel or urinary tract. Surgical therapies for endometriosis may be either classified as conservative, in which the uterus and ovarian tissue is preserved, or definitive, which involves hysterectomy (removal of the uterus), with or without removal of the ovaries.
Conservative surgery is typically carried out by laparoscopy. Endometrial implants may be excised or obliterated by laser. If the disease is extensive and anatomy is distorted, laparotomy (opening of the abdominal wall via a larger incision) may be required.
While surgical treatments can be very effective in the reduction of pain, the recurrence rate of endometriosis following surgical treatment has been estimated to be as high as 40%. Many doctors recommend for women who have had surgery for endometriosis to take oral medications after surgery to help maintain symptom relief.

Treatment of infertility associated with endometriosis

Endometriosis is more common in infertile, compared to fertile, women. However, the condition usually does not fully prevent conception. Most women with endometriosis will still be able to conceive, especially those with mild to moderate endometriosis. It is estimated that up to 70% of women with mild and moderate endometriosis will conceive within three years without any specific treatment.
The reasons for a decrease in fertility are not completely understood, but might be due to both anatomic and hormonal factors. The presence of endometriosis may involve masses of tissue or scarring (adhesions) within the pelvis that may distort normal anatomical structures, such as Fallopian tubes, which transport the eggs from the ovaries. Alternatively, endometriosis may affect fertility through the production of hormones and other substances that have a negative effect on ovulation, fertilization of the egg, and/or implantation of the embryo. Infertility associated with endometriosis is more common in women with severe forms of the disease.
Treatment options for infertility associated with endometriosis are varied, but most doctors believe that surgical treatments are superior to hormonal or medical treatments for endometriosis when the goal is enhancement of fertility. Assisted reproduction techniques may also be used when appropriate in combination with surgical therapy.

What causes endometriosis?

2013-07-27T21:55:00.003-07:00

What causes endometriosis?

The cause of endometriosis is unknown. One theory is that the endometrial tissue is deposited in unusual locations by the backing up of menstrual flow into the Fallopian tubes and the pelvic and abdominal cavity during menstruation (termed retrograde menstruation). The cause of retrograde menstruation is not clearly understood. But retrograde menstruation cannot be the sole cause of endometriosis. Many women have retrograde menstruation in varying degrees, yet not all of them develop endometriosis.
Another possibility is that areas lining the pelvic organs possess primitive cells that are able to grow into other forms of tissue, such as endometrial cells. (This process is termed coelomic metaplasia.)
It is also likely that direct transfer of endometrial tissues during surgery may be responsible for the endometriosis implants sometimes seen in surgical scars (for example, episiotomy or Cesarean section scars). Transfer of endometrial cells via the bloodstream or lymphatic system is the most likely explanation for the rare cases of endometriosis that develop in the brain and other organs distant from the pelvis.
Finally, there is evidence that shows alternations in the immune response in women with endometriosis, which may affect the body's natural ability to recognize and destroy any misdirected growth of endometrial tissue.

What are endometriosis symptoms?

Most women who have endometriosis, in fact, do not have symptoms. Of those who do experience symptoms, the common symptoms are pain (usually pelvic) and infertility. Pelvic pain usually occurs during or just before menstruation and lessens after menstruation. Some women experience painful sexual intercourse (dyspareunia) or cramping during intercourse, and or/pain during bowel movements and/or urination. Even pelvic examination by a doctor can be painful. The pain intensity can change from month to month, and vary greatly among women. Some women experience progressive worsening of symptoms, while others can have resolution of pain without treatment.
Pelvic pain in women with endometriosis depends partly on where the implants of endometriosis are located.

Deeper implants and implants in areas with many pain-sensing nerves may be more likely to produce pain.
The implants may also produce substances that circulate in the bloodstream and cause pain.
Lastly, pain can result when endometriosis implants form scars. There is no relationship between severity of pain and how widespread the endometriosis is (the "stage" of endometriosis).

Endometriosis can be one of the reasons for infertility for otherwise healthy couples. When laparoscopic examinations are performed for infertility evaluations, endometrial implants can be found in some of these patients, many of whom may not have painful symptoms of endometriosis. The reasons for a decrease in fertility are not completely understood, but might be due to both anatomic and hormonal factors. The presence of endometriosis may involve masses of tissue or scarring (adhesions) within the pelvis that may distort normal anatomical structures, such as Fallopian tubes, which transport the eggs from the ovaries. Alternatively, endometriosis may affect fertility through the production of hormones and other substances that have a negative effect on ovulation, fertilization of the egg, and/or implantation of the embryo

Endometriosis and cancer risk

Women with endometriosis have an increased risk for development of certain types of cancer of the ovary, known as epithelial ovarian cancer (EOC), according to some research studies. This risk is highest in women with endometriosis and primary infertility (those who have never borne a child), but the use of oral contraceptive pills (OCPs), which are sometimes used in the treatment of endometriosis, appears to significantly reduce this risk.
The reasons for the association between endometriosis and ovarian epithelial cancer are not clearly understood. One theory is that the endometriosis implants themselves undergo transformation to cancer. Another possibility is that the presence of endometriosis may be related to other genetic or environmental factors that also increase a women's risk of developing ovarian cancer.

How is endometriosis diagnosed?

Endometriosis can be suspected based on symptoms of pelvic pain and findings during physical examinations in the doctor's office. Occasionally, during a rectovaginal exam (one finger in the vagina and one finger in the rectum), the doctor can feel nodules (endometrial implants) behind the uterus and along the ligaments that attach to the pelvic wall. At other times, no nodules are felt, but the examination itself causes unusual pain or discomfort.
Unfortunately, neither the symptoms nor the physical examinations can be relied upon to conclusively establish the diagnosis of endometriosis. Imaging studies, such as ultrasound, can be helpful in ruling out other pelvic diseases and may suggest the presence of endometriosis in the vaginal and bladder areas, but still cannot definitively diagnose endometriosis. For an accurate diagnosis, a direct visual inspection inside of the pelvis and abdomen, as well as tissue biopsy of the implants are necessary.
As a result, the only accurate way of diagnosing endometriosis is at the time of surgery, either by opening the belly with large-incision laparotomy or small-incision laparoscopy.
Laparoscopy is the most common surgical procedure for the diagnosis of endometriosis. Laparoscopy is a minor surgical procedure done under general anesthesia, or in some cases under local anesthesia. It is usually performed as an out-patient procedure (the patient going home the same day). Laparoscopy is performed by first inflating the abdomen with carbon dioxide through a small incision in the navel. A long, thin viewing instrument (laparoscope) is then inserted into the inflated abdominal cavity to inspect the abdomen and pelvis. Endometrial implants can then be directly seen.
During laparoscopy, biopsies (removal of tiny tissue samples for examination under a microscope) can also be performed for a diagnosis. Sometimes biopsies obtained during laparoscopy show endometriosis even though no endometrial implants are seen during laparoscopy.
Pelvic ultrasound and laparoscopy are also important in excluding malignancies (such as ovarian cancer) that can cause symptoms that mimic endometriosis symptoms.

How is endometriosis treated?

Endometriosis can be treated with medications and/or surgery. The goals of endometriosis treatment may include pain relief and/or enhancement of fertility.

Medical treatment of endometriosis

Nonsteroidal anti-inflammatory drugs or NSAIDs (such as ibuprofen or naproxen sodium) are commonly prescribed to help relieve pelvic pain and menstrual cramping. These pain-relieving medications have no effect on the endometrial implants. However, they do decrease prostaglandin production, and prostaglandins are well-known to have a role in production of pain sensation. Because the diagnosis of endometriosis is only definite after a woman undergoes surgery, there will of course be many women who are suspected of having endometriosis based on the nature of their pelvic pain symptoms. In such a situation, NSAIDs are commonly used, such as naproxen or ibuprofen, are commonly used. If they work to control pain, no other procedures or medical treatments are needed. If they do not relieve the pain, additional evaluation and treatment generally occur.
Since endometriosis occurs during the reproductive years, many of the available medical treatments for endometriosis rely on interruption of the normal cyclical hormone production by the ovaries. These medications include GnRH analogs, oral contraceptive pills, and progestins.

Gonadotropin-releasing hormone analogs (GnRH analogs)
Gonadotropin-releasing hormone analogs (GnRH analogs) have been effectively used to relieve pain and reduce the size of endometriosis implants. These drugs suppress estrogen production by the ovaries by inhibiting the secretion of regulatory hormones from the pituitary gland. As a result, menstrual periods stop, mimicking menopause. Nasal and injection forms of GnRH agonists are available.
The side effects are a result of the lack of estrogen, and include:

hot flashes,
vaginal dryness,
irregular vaginal bleeding,
mood changes,
fatigue, and
loss of bone density (osteoporosis).

Fortunately, by adding back small amounts of estrogen and progesterone in pill form (similar to treatments sometimes used for symptom relief in menopause) many of the annoying side effects due to estrogen deficiency can be avoided. "Add back therapy" is the term that refers to this modern way of administering GnRH agonists along with estrogen and progesterone in a way to keep the treatment successful, but avoid most of the unwanted side effects.
Oral contraceptive pills
Oral contraceptive pills (estrogen and progesterone in combination) are also sometimes used to treat endometriosis. The most common combination used is in the form of the oral contraceptive pill (OCP). Sometimes women who have severe menstrual pain are asked to take the OCP continuously, meaning skipping the placebo (sugar pill) portion of the cycle. Continuous use in this manner will free a woman of having any menstrual periods at all. Occasionally, weight gain, breast tenderness, nausea, and irregular bleeding are mild side effects. Oral contraceptive pills are usually well-tolerated in women with endometriosis.
Progestins
Progestins [for example, medroxyprogesterone acetate (Provera, Cycrin, Amen), norethindrone acetate, norgestrel acetate (Ovrette)] are more potent than birth control pills and are recommended for women who do not obtain pain relief from or cannot take a birth control pill.
Side effects are more common and include:

Since the absence of menstruation (amenorrhea) induced by high doses of progestins can last many months after cessation of therapy, these drugs are not recommended for women planning pregnancy.
Other drugs used to treat endometriosis
Danazol (Danocrine)
Danazol (Danocrine) is a synthetic drug that creates a high androgen (male type hormone) and low estrogen hormonal environment by interfering with ovulation and ovarian production of estrogen. Eighty percent of women who take this drug will have pain relief and shrinkage of endometriosis implants, but up to 75% of women develop side effects from the drug.
Side effects can include:

weight gain,
edema,
decreased breast size,
acne,
oily skin,
hirsutism (male pattern hair growth),
deepening of the voice,
headache,
hot flashes,
changes in libido, and
mood changes.

All of these changes are reversible, except for voice changes; but the return to normal may take many months. Danazol should not be taken by women with certain types of liver, kidney, and heart conditions.
Aromatase inhibitors
A newer approach to the treatment of endometriosis has involved the administration of drugs known as aromatase inhibitors (for example, anastrozole [Arimidex] and letrozole [Femara]). These drugs act by interrupting local estrogen formation within the endometriosis implants themselves. They also inhibit estrogen production in the ovary, brain, and other sources, such as adipose tissue. Research is still ongoing to characterize the effectiveness of aromatase inhibitors in the management of endometriosis. Aromatase inhibitors cause significant bone loss with prolonged use and cannot be used alone without other medications such as GnRH agonists or combination of oral contraceptives in premenopausal women because they stimulate development of multiple follicles at ovulation.

Endometriosis Symptoms

2013-07-27T21:48:00.003-07:00

What is endometriosis?

Endometriosis is the abnormal growth of cells (endometrial cells) similar to those that form the inside or lining the tissue of the uterus, but in a location outside of the uterus. Endometrial cells are cells that are shed each month during menstruation. The cells of endometriosis attach themselves to tissue outside the uterus and are called endometriosis implants. These implants are most commonly found on the ovaries, the Fallopian tubes, outer surfaces of the uterus or intestines, and on the surface lining of the pelvic cavity. They can also be found in the vagina, cervix, and bladder, although less commonly than other locations in the pelvis. Rarely, endometriosis implants can occur outside the pelvis, on the liver, in old surgery scars, and even in or around the lung or brain. Endometrial implants, while they can cause problems, are benign (not cancerous).

Who is affected by endometriosis?

Endometriosis affects women in their reproductive years. The exact prevalence of endometriosis is not known, since many women may have the condition and have no symptoms. Endometriosis is estimated to affect over one million women (estimates range from 3% to 18% of women) in the United States. It is one of the leading causes of pelvic pain and reasons for laparoscopic surgery and hysterectomy in this country. Estimates suggest that between 20% to 50% of women being treated for infertility have endometriosis, and up to 80% of women with chronic pelvic pain may be affected.
While most cases of endometriosis are diagnosed in women aged around 25 to 35 years, endometriosis has been reported in girls as young as 11 years of age. Endometriosis is rare in postmenopausal women. Endometriosis is more commonly found in white women as compared with African American and Asian women. Studies further suggest that endometriosis is most common in taller, thin women with a low body mass index (BMI). Delaying pregnancy until an older age is also believed to increase the risk of developing endometriosis. It also is likely that there are genetic factors that predispose a woman to developing endometriosis, since having a first-degree relative with the condition increases the chance that a woman will develop the condition.

Endometriosis Symptoms

Common Endometriosis Symptoms

lower abdominal pain,
diarrhea and/or constipation,
low back pain,
irregular or heavy menstrual bleeding, or
blood in the urine.

Rare symptoms of endometriosis include chest pain or coughing blood due to endometriosis in the lungs and headache and/or seizures due to endometriosis in the brain.

Endometriosis facts

Endometriosis is the abnormal growth of cells (endometrial cells) similar to those that form the inside of the uterus, but in a location outside of the uterus. Endometriosis is most commonly found on other organs of the pelvis.
The exact cause of endometriosis has not been identified.
Endometriosis is more common in women who are experiencing infertility than in fertile women, but the condition does not fully prevent conception.
Most women with endometriosis have no symptoms, in which case therapy is neither appropriate nor necessary.
Pelvic pain during menstruation or ovulation can be a symptom of endometriosis, but may also occur in normal women.
Endometriosis can be suspected based on the woman's pattern of symptoms, and sometimes during a physical examination, but the definite diagnosis is confirmed by surgery, usually laparoscopy.
Treatment of endometriosis includes medication and surgery for both pain relief and treatment of infertility if pregnancy is desired

Lung Wet Disease

2011-06-14T12:06:00.000-07:00

Disease Info

Lung wet

Definition:
Effusi pleural or pneumonia is a condition where a person pleural cavity fills with fluid. Pleural cavity is a cavity that surrounds the lungs that is normally filled with a little liquid that serves as a lubricant at the time breathing, so the time to breathe, when pau inflate and deflate the painful friction does not occur. This fluid is produced and absorbed in the same amount so that the amount fixed.

Cause:
In pleural effusions, there was accumulation of fluid in the pleural cavity. This can happen because the amount of production increases or decreases the amount of absorption. So there is excess fluid in the cavity. The cause of this fluid accumulation can vary. Among other good infection-specific infection that is usually caused by TB germs, as well as non-specific infections caused by germs or microorganisms other than tuberculosis. In addition to infection can also be caused by either cancer of the lung cancer (this is the largest) and lung cancer beyond that already spread (metastasis) to the lungs. Auto immune diseases can also cause this fluid buildup. Also outside the lung diseases can also cause pleural effusion. Among other diseases of heart failure, kidney failure and liver failure / liver. Where in diseases outside the lung is usually in addition there are also accompanied with pleural effusion swelling in other parts of the body such as swelling in the leg, in the face and the abdomen (ascites).

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Various Diseases

2011-06-04T20:02:00.000-07:00

Contains information about all sorts of diseases, such as heart disease, cancer, stroke, and others.

as bellow:

heart desease

cancer

Heart Disease Heart Attack

2011-06-04T19:48:00.000-07:00

Heart
The heart is a muscle that pumps blood throughout the body. In a heart attack (myocardial infarction), part of the heart muscle to die while not getting blood. To stay healthy, the heart requires oxygen and other nutrients carried by blood. This is obtained through the artery (blood vessel) disease, which wrap the outside of the heart.

Heart DiseaseHeart Attack
These diseases can affect any part of the heart. However, the most common disease is a chronic disease in the coronary artery is called atherosclerosis.
Therefore, heart disease commonly known and most common is coronary heart disease or coronary artery disease. The disease is most often causes a heart attack in someone who can cause death. The cause is narrowing of the coronary arteries, where the vessel serves to provide blood to the heart muscle. The narrowing is caused by a pile of cholesterol or other proteins derived from food intake in the body. This buildup causes the coronary arteries become stiff. Rigidity is referred to as atherosclerosis.
Atherosclerosis occurs if there is buildup of plaque or fatty deposits in artery walls. Over time, plaque can accumulate, harden and narrow the arteries, and inhibit blood flow to the heart. Coronary artery disease or coronary artery disease (CAD) is that basically leads to most heart attacks.
Blockage in one or more coronary arteries can cause heart attack suddenly. The reason for the heart to ask exceeds the available oxygen so that trigger heart attacks. Why? If the heart muscle does not receive oxygen for a long time, the surrounding tissue can be damaged. Unlike other tissues, the heart muscle does not regenerate. The longer the attack, the more damage to the heart and the more likely die.
Even in the arteries that are not too narrow because timbungan plaque and fat, accumulation of plaque can rupture and form a crust of blood or thrombus. In addition, the diseased arteries also tend to experience sudden muscle contractions. Thus, a piece of crust of blood can form a contraction, releasing chemicals which then result in narrowing the artery wall, triggering a heart attack.
If the working system of the heart is damaged, the normal heart rhythm can become chaotic and the heart began to tremble with uncertainty or experiencing fibrillation. This abnormal rhythm known as arrhythmia is a deviation from normal heart rhythm. This will cause the heart loses its ability to pump blood effectively to the brain. Within ten minutes, brain death and the patient was beyond help.
In addition to coronary heart disease due to fat deposition in the arterial wall, there are also other heart diseases caused by abnormalities at birth. For example, an imperfect heart, heart valve disorders, weakened heart muscle. Another cause is the bacteria that cause infections of the heart.

Symptoms of Heart DiseaseIf symptoms of heart attacks happen to you:
Recognize any of these symptoms if there is chest pain, shortness of breath, or palpitations.
Cease immediately all work no matter what you are doing and sit or lie down while you draw a deep breath.
If you are alone while symptoms last more than a few minutes immediately contact the local emergency phone number and say you have a heart attack. Or contact the people around you by giving the same information.
If anyone can take you to the hospital more quickly than the arrival of paramedics, immediately ask for help going to take you to the emergency room at the hospital. Faster would be better handled.
But if you wait for a team of paramedics arrived, so while waiting, you can loosen tight clothing, including a belt or tie. Make yourself in a position that feels comfortable.
Stay calm, no matter you are the victim or his salvation. The panic may increase the likelihood of arrhythmia or heart rhythm irregularities that threaten life.
The symptoms are perceived if you have coronary heart disease include pain or pain in the chest in which most people thought it was just as indigestion. Then other symptoms of feeling depressed in the middle of the chest for 30 seconds to 5 minutes. Another thing is the cold sweat, palpitations, dizziness, and felt like fainting. These symptoms are not always perceived sufferer. Another warning sign is gasping for breath during exercise.
For several months before the heart attack usually people with heart disease often feel very tired. Do not assume these symptoms are caused by lack of sleep and stress of the job.
Pain or feeling of pressure in the chest, called angina, give warning to half of those who suffer a heart attack. Some people get breathless or exhausted and feeling weak as the symptoms, indicating that the heart is not getting enough oxygen due to blockage of a coronary.
Usually a few days before having a massive heart attack, a person will experience muscle contractions suddenly in the chest which is a small attack or a mild heart attack. Generally mild heart attack occur before a major attack a few days later.

Tips for Preventing Heart DiseaseTo reduce risk of coronary heart disease, you can do the following things:

    Healthy diet
    Avoid foods that contain lots of fat or high cholesterol. Seafood contains high cholesterol that can harm the heart. Reduce eating fried foods that contain lots of fat, otherwise the food can be processed by boiling, steaming or roasting.

    Wherever possible, the food products we eat low-fat or no fat. Choose milk, cheese, butter or other foods that are low in fat. Fry using olive oil has less fat content so that it can be an option if the need to process food by frying.

    Apart from avoiding fatty foods, avoid foods with sugar content is also high, such as soft drinks. Do not consume too much karbohirat tertalu, because in the body, carbohydrates are broken down into fat. In contrast, consumption of oats or wheat that can help keep the heart healthy.

    Keep your diet in moderation to avoid obesity, because someone who has a waist circumference of more than 80 cm, greater risk of developing this disease.

Stop smoking
Cigarette is not good for heart health, then immediately stop this practice for heart stay healthy.

Avoid Stress
Stress is very difficult to avoid when living in big cities like Jakarta, which is known for its jams and preoccupations. When a person experiences stress, the body will release the hormone cortisol, which causes the blood vessels become stiff. Hormone norepinephrine would produce the body when suffering from stress, which will result in increased blood pressure. So, very good if you avoid the stress both in the office or at home.

Hypertension
Problem hypertension or high blood pressure can also cause heart disease. Hypertension can injure the arterial wall and allows the LDL cholesterol into the arterial line and increase the accumulation of plaque.

Obesity
Overweight or obese increases the high blood pressure and abnormal fat. Avoiding or treating obesity or obesity is the main way to avoid diabetes. Diabetes accelerate coronary heart disease and increased risk of heart attack.

Exercise regularly
You can do sports activities such as walking, brisk walking, or jogging. Sporting activities which are neither too much competition and not to strengthen the work of the heart and blood circulation throughout the body.

Consumption of antioxidants
Air pollution, motor vehicle fumes or cigarette smoke create the emergence of free radicals in the body. Free radicals can cause ulcers or deposition of the arteries that can cause blockages. To remove the content of free radicals in the body, there needs to be an antioxidant that will catch and throw. Antioxidants can be obtained from a variety of fruits and vegetables.

Offspring
A person who is a parent or sibling had suffered a heart attack before age 60 have a greater risk of suffering from this disease. Therefore, if you have relatives who have had a heart attack, you should be more careful in keeping to your diet and your lifestyle to support a healthy heart.

Overcoming Heart DiseaseIf you feel the early symptoms of heart disease or had suffered a mild heart attack, do not ignore it. You really need early treatment by trained medical personnel. This can save the heart from further damage and even to avoid more fatal consequences such as death.
But if heart attack symptoms begin to occur, it is important to seek immediate medical assistance. The biggest risk of death from heart attack is within one hour after a heart attack. Rapid and appropriate treatment of a medical team to save heart muscle from damage that can not be repaired. The more heart muscle that is saved, the more effective heart pumping will return after the attack. Do not put off getting medical help because of fear is considered absurd.
When a blockage has occurred, the medical action is generally taken with the installation of catheterization and rings that keep coronary arteries are not clogged. However, there may be some blockage in other arteries.

Love Your Heart
Looking at the heart of this precious organ for survival, then immediately improve your lifestyle to stay healthy. Start enjoying a healthy diet, nutritious and low in cholesterol. Avoid smoking and stress. And exercise regularly. Start with a healthy lifestyle from this day to love your heart.