Discover Glutathione - The Master Antioxidant

Immunocal - Your Defense Against Disease & Aging

noreply@blogger.com (Dave) — Mon, 08 Sep 2008 03:02:00 +0000

Dr. James Balch, distinguished co-author of best selling books, “Prescription for Natural Cures” and “Prescription for Nutritional Healing” with over 8 Million copies sold has this to say about Immunocal….

“I can’t think of anything better you can do for your overall health and wellbeing than taking Immunocal on a regular basis” Dr. James Balch

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Immunocal Platunum - Glutathione Precursor

noreply@blogger.com (Dave) — Mon, 08 Sep 2008 01:46:00 +0000

PROVEN TO RAISE GLUTATHIONE (GSH):

1) Referred to by scientists as the Master Antioxidant

2) Is food for the Immune system

3) Detoxifies the liver

YOUR DEFENSE AGAINST DISEASE AND AGING

Immunocal Platinum:

* Raises immune response (T-cells)
* Repairs damaged cells
* Prevents the formation of abnormal cells
* A new weapon in slowing down aging
* Regulates insulin production
* Prevents calcium loss
* Maintains our body in an alkaline state. A body in an acid state has been proven to be susceptible to disease.

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Glutathione Booster - The Master Antioxidant

noreply@blogger.com (Dave) — Thu, 24 Apr 2008 22:08:00 +0000

The new knowledge found by scientists connecting free radicals to a number of degenerative biologic functions, combined with the increase in the median age, has made interest in antioxidants skyrocket. Because the population wants to enjoy life as much as possible and are willing to fight the effects of aging from all angles, antioxidants are becoming the choice
weapon to do this. Even though consumers are not always able to interpret the scientific jargon about antioxidants and how they work, they do have a feeling that they do work and are, in
general, safe and an essential part of a proper diet.

Antioxidants are powerful compounds which are able to stop the rush of cellular damage that are caused by free-radicals. Oxidants can damage cells by starting chemical chain reactions, or even damaging DNA at the cellular level. Because DNA is the blueprint for our cells to reproduce, damage to it can cause serious problems. Thankfully, Immunotoc Research has found a way to fight oxidative damage by manufacturing antioxidant compounds within the body. However, levels of these fighters decline along with age, causing ingestion of antioxidants more
and more important.

The body creates glutathione peroxidase (GPx) as its own protective mechanism to target lipid hydroperoxide and hydrogen peroxide. By taking a daily supplement called Immunocal you can give you body the building block it needs to produce GSH. Superoxide dismutase (SOD) is also created in the body to target free radicals and break it down into hydrogen peroxide and oxygen. With SOD supplementation, you can protect DNA from oxidative damage and increase the blood antioxidant activity and improve health.

By controlling free radical production before the chain reaction of damage can occur, oxidative stress and the human diseases associated with it can be avoided. Consumers are encouraged to take a comprehensive multivitamin/mineral product that are loaded with vitamin A, C, D and other substances that act as an antioxidant and fight free radical damage like Immunotec's NEW Multivitamin.

Because the brain has high levels of lipids, it is especially susceptible to oxidation, causing damage to cells, tissues, and genetic material. Unchecked oxidation can contribute to the
development of illnesses including Alzheimer's disease, Parkinson's disease, and dementia. Several antioxidant compounds have been shown in studies to produce positive results including
Carotenoids, vitamins A, C, and E, tocotrienol, alpha lipoic acid, melatonin, grape seed extract, and pomegranate.

Berries, especially cranberry and blueberry are extremely rich in antioxidant polyphenols. These, along with Omega 3, are extremely useful to help prevent oxidative stress that can
affect the heart. It is recommended by the American Health Association to consume a diet high in food sources of antioxidants and other heart-protecting nutrients including fruits, vegetables, whole grains, and nuts. A combination of Immunocal and vitamin supplements and good diet can help one live a longer healthier life.

Turmeric may help with heart disease.

noreply@blogger.com (Dave) — Sat, 29 Mar 2008 14:50:00 +0000

Toronto animal study showed "dramatic" results.

The spice that gives the kick to many Indian curry dishes might also help prevent the ravages of heart failure, a surprising new Canadian animal study has concluded. This spice is also found in a synergistic combination with Immunotec's Omega 3 daily supplement.

Researchers at Toronto's University Health Network found that curcumin, the active ingredient in turmeric, both prevents and dramatically reverses enlargement of the heart in mice.

Enlarged hearts can lead to cardiac failure, a common and often fatal condition where the organ is unable to pump enough blood to keep the body functioning properly.

If similar results were one day duplicated in humans, the widely available spice could repair heart damage in a way no drug is able to do now, say researchers behind the study, to be published Friday in the Journal of Clinical Investigation. Curcumin has the added benefit of causing virtually no toxic side effects in even relatively large doses.

Despite their earlier hopes for the ingredient, researchers were taken aback by the scope of the improvement it actually made to the mice hearts.

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"That was quite a surprise," said Dr. Maral Ouzounian, a research fellow at the network's Peter Munk Cardiac Centre. "It was quite dramatic."

The next step is to try to repeat the study in mice, then begin human studies, Dr. Ouzounian said. Even if it proves effective in people, however, curcumin as a treatment would probably not be on the market for another decade, said one scientist yesterday.

In the meantime, people should follow the usual steps for preventing heart failure: keeping blood pressure down, reducing cholesterol, exercising and eating healthily, the researchers said.

The new study is the latest to find promise in curcumin as a medicine, though it has long been used as a natural remedy in some Asian cultures. Human trials are underway to test the substance's efficacy in treating colorectal and pancreas cancer and Alzheimer's disease, after hopeful findings in animal studies.

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Traditionally, it has been used in places such as India to heal cuts with a minimal of scarring, and fight everything from kidney disease to cataracts, though most of those applications have not been proven scientifically.

An animal study is a long way from a discovery applicable to humans, but the new research is good news, said Dr. Andreas Wielgosz, an Ottawa cardiologist and spokesman for the Heart and Stroke Foundation. The foundation partly funded the Toronto study.

"The potential is tremendous because of all the people who develop heart failure," he said. "Potentially, it would be very useful because it would reverse some of the damage to the heart muscle."

Heart failure affects about 400,000 Canadians, and 40%-50% die within five years of being diagnosed, according to foundation figures.

Factors such as high blood pressure that put excess stress on the heart sometimes lead to enlargement or thickening of the heart muscle - called cardiac hypertrophy. If the underlying causes of the hypertrophy are not countered with medication or lifestyle changes, the condition can lead to heart failure.

Though curcumin had never been tried before in treating heart disease, the team led by Dr. Peter Liu of the Munk centre speculated that its anti-inflammatory properties might be applicable to cardiac hypertrophy.

What they found is that the substance actually interacted with the nucleus of heart cells, blocking activation of the genes that are turned on in the hypertrophy process.

The resulting reversal of heart enlargement or thickening was striking, clearly visible with the naked eye and in ultrasound images, said Dr. Ouzounian. "The changes we saw ... would be clinically meaningful."

A different test showed that curcumin could also prevent hypertrophy from happening.

The ingredient's medicinal potential seems generally to stem from its ability to attack "what's going on in cells at the nucleus level," said the researcher.

Current treatment of hypertrophy centres around using drugs such as beta-blockers and ACE inhibitors to combat underlying causes like high blood pressure. No therapy at the moment can actually correct damage already done to the heart, Dr. Ouzounian said.

These Products Can Change Your Life.

Why Take Immunocal / HMS 90

noreply@blogger.com (Dave) — Mon, 24 Mar 2008 22:59:00 +0000

“I don’t have any health problems…. I feel fine!

Why should I take Immunocal™/HMS90™?”

Based on the amount of pollution in the air we breathe acceptable contamination and chemicals in the food and water we consume and the thoughtless exposure to other people’s contagious ailments we encounter on a daily basis, everyone should be taking Immunocal™/HMS90™. Your immune system is the only natural defense your body has against these harmful intruders. Immunocal or HMS 90 as it is called in Canada helps keep your immune system at its optimum level so it can effectively combat these constant threats to your body.

These products can change your life.

If you are middle-age or older, you have probably witnessed changes in your body’s appearance when stepping out of the shower and standing in front of a mirror. Most of the changes seen in our reflection are actually originating from the changes taking place inside the body. It is nature’s way of letting you know your body is gradually losing the ability to maintain itself. Many people, who witness changes in their appearance, will run out and buy vitamins, minerals and other nutritional supplements in hopes of regaining their youth. Others will begin diets or exercise and jogging routines in an effort to improve their body’s appearance and perhaps their overall health.

Unfortunately, few people ever consider their immune system. Very few really know anything about their immune system and how it is suppose to function. Most people take the immune system for granted. The truth is, even the healthiest immune system fluctuates on a daily basis.

Strenuous exercise, dieting and fatigue from working can all reduce the efficiency of our immune system. The lower your immune system drops, the more vulnerable you become when exposed to virus or flu bacteria and other contagious ailments.

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Every part of your body competes for the antibodies produced by your immune system. Your liver is the filter system for your body so it demands a majority of the available antibodies to combat chemicals, pollution and toxic substances that enter your body.

Each organ within your body has a specific and dedicated function. Your immune system is a guardian to protect the health of each organ and your entire body. Nothing can do more to protect your overall health than maintaining your immune system at its optimum level. In fact, researchers have found that a low immune system drastically reduces the benefits a person ca receiver from vitamins, minerals and other supplements. This finding holds true with many treatment medications. The lower the immune system, the less effective any treatment becomes. So, if you want to get your money’s worth from the medications and supplements you take you should elevate your immune system first. Immunocal™/HMS90™ is patented and supported by clinical studies to perform according to its manufacturer’s claims.

Research has determined that once a person passes the age of fifty, the efficiency of their immune system can drop as much as 34%. Perhaps this explains why so many seniors are making more frequent trips to their doctors. A daily dose of Immunocal™/HMS90™ will maintain the immune system at its optimum level which can allow the body to provide a natural defense for combating aging and many of the age related ailments.

More and more healthcare professionals are in agreement, based on the lack of natural nutrients in the food groups, people should be taking nutritional supplements to ensure their own better health. The most recommended are vitamins, minerals and antioxidants. Immunocal™/HMS90™ is not only an antioxidant but it provides the body with the ability to take full advantage of any other vitamin, mineral or antioxidant supplement.

These products can change your life.

Of all the supplements available on the market today, Immunocal™/HMS90™ is the only natural product that is specifically produced to elevate your body’s immune response system.

Help your Body Heal Itself…

Take Immunocal/HMS90 Every Day!

noreply@blogger.com (Dave) — Sat, 22 Mar 2008 03:12:00 +0000

Watch a Video Tour of Immunotec Products and Business Opportunity

What is Immunocal/HMS 90- Frequently Asked Questions

noreply@blogger.com (Dave) — Tue, 26 Feb 2008 14:02:00 +0000

Immunocal/HMS 90 Questions and Answers

Q. What is Immunocal®? What is HMS-90®?

A. Immunocal® is known as HMS90® in Canada. This unique product is manufactured by Immunotec Research in Montreal, Canada. It is not a prescription drug, but a powerful and patented un-denatured and highly bioactive whey protein dietary supplement that is loaded with glutathione precursors.

Immunocal® took $10 million and 18 years of research to perfect. It is unique in the nutritional field as it is covered by 10 ‘Method of Use’ patents worldwide: 5 in the US, 3 in Canada and 2 in Australia. Immunocal® is a highly concentrated milk serum isolate which is high in protein (90% protein by weight) and is lactose-free and fat-free. Immunocal® shares many of the same immune promoting and enhancing properties of Mother's milk. Immunocal® has been clinically proven to increase serum and tissue glutathione levels, and its efficacy is validated by extensive research, including over 450 that appear in the medical literature. These scientific papers can be examined through MEDLINE (the US National Library of Medicine). Immunocal® increases glutathione which is your cells' own natural antioxidant and most potent detoxifier. Immunocal® has been demonstrated to enhance both healthy and deficient immune systems, and is validated as an effective nutritional supplement by the medical community. Immunocal® has its own NDC (National Drug Control) number, and is reimbursable under Medicaid, Medicare, and by private insurance in many states.

Q. Can children take Immunocal?

A. Yes they certainly can. There is no problem with side effects or worry about conflicts with medication. Children should be given 11/4 teaspoon of Immunocal for every 3 lbs of body weight.

Q. What is the difference between Immunocal and other whey proteins?

A. Immunocal has been shown to differ from other whey proteins in its effect upon the immune system. Specifically, scientific studies on other whey proteins have not shown the same immune stimulating effects that are seen with Immunocal®. Immunocal has been extensively studied in the clinical literature. Comparing the bioactive ingredients in Immunocal to those in other whey proteins clearly shows the superiority of Immunocal®. Immunocal is a bioactive dietary supplement that is supported by eighteen years of research through rigorous clinical trials that have been published in peer review journals. These studies, performed in world-renowned medical and scientific institutions, attest to the efficacy of Immunocal. Immunocal studies have shown that Immunocal not only increases intracellular levels of GSH (glutathione or glutathione precursors) following ingestion, but also significantly builds up the stores of these substances inside the cells. This beneficial effect lasts for considerable periods of time after ingestion of Immunocal.

Q. What is the product's bioactivity dependent upon?

A. Concentrations of 3 bioactive and thermo labile (easily damaged by heat) proteins that are contained in the milk serum: serum albumin, alpha lactalbumin and lactoferrin. Because these compounds can be damaged by heat (in excess of 140 degrees F) or excessive mechanical agitation, Immunocal® must not be cooked, heated, or placed in a steel-bladed blender. For these reasons, and to preserve the bioactivity of its serum albumin, alpha lactalbumin and lactoferrin, Immunocal® has not been exposed to standard high-temperature Pasteurization. Rather, it has been bio-filtered to remove bacteria, and subjected to a patented process of low-temperature purification procedures to ensure its safety and purity.

Q. If a different manufacturer of whey protein supplements was able to duplicate our technology, could they make the same claims?

A. No. The power of our patents is not in manufacturing. Immunocal patents (presently there are ten patents on Immunocal®: 5 US patents, 3 Canadian and 2 Australian patents relate to the METHOD OF USE. That is, no other whey protein can state: "clinically PROVEN to stimulate the immune system", and "significantly raises glutathione levels". Additionally, although there are dozens of companies producing DENATURED (high-heat Pasteurized) whey proteins (primarily for use as a protein source in body-building), there currently is no company manufacturing an UNDENATURED whey protein product similar to Immunocal. Over 450 clinical studies and medical reviews appear in the clinical literature which specifically involved Immunocal®, and not other whey proteins. Accept no imitations.

Q. What exactly is glutathione (GSH) and how is it important?

A. Glutathione is the master antioxidant of the body. Without glutathione, we would die. The replenishment of the glutathione levels within the lymphocytes (also called leukocytes or white blood cells) increases the intensity of the immune response. The increase in glutathione levels also results in the proliferation of lymphocytes that act as scavengers, and helps to combat infections. Selenium is a structural component of, and a co-factor for the antioxidant enzyme glutathione peroxidase. For this reason, supplementation with selenium can modestly increase glutathione levels in persons who are selenium deficient. Glutathione is a tri-peptide of the amino acids cysteine, glycine, and glutamic acid. Tissue glutathione levels increase when cystine levels increase within the cell. This is why cystine is critical in the production of glutathione. Prior to the development of Immunocal, no effective way was known to safely and significantly increase cystine levels in the cell over long periods of time. A deficiency of glutathione can cause haemolysis (the destruction of red blood cells resulting in severe anaemia) and numerous diseases of oxidative stress. Glutathione is essential in intermediary metabolism as a donor of sulfhydryl groups that are essential for the detoxification of the liver. The antioxidant enzyme glutathione peroxidase functions in the process of elimination of wastes from the body. Glutathione works within the liver, lungs, colon, kidneys, and skin in the process of removing toxic cellular metabolic wastes.

Q. What is the difference between products or pills that people use as supplements that are labelled as "glutathione" or "cystine"?

A. Glutathione must be produced within the cells (intra-cellularly). Clinical and laboratory studies demonstrate that oral glutathione is NOT absorbed but will be eliminated by the liver through the bile before ever reaching the systemic circulation (blood stream). Several studies have suggested that supplementing with oral glutathione may actually do the reverse and depress cellular and blood levels of glutathione. Injectable glutathione also has limited benefits. It is unstable in the blood stream. By the time it reaches the cell, much of it has been degraded, and much of the remaining glutathione cannot effectively pass through the cell membrane. Cystine is not well absorbed when taken by mouth. Clinical studies have demonstrated that oral cystine supplementation (NAC or N Acetyl LCysteine) is not effective in increasing cystine levels within the cell, and also has not been associated with significant increases in glutathione levels within the cell. The three bioactive proteins supplied by Immunocal constitute a "natural delivery system" from these cystine precursors to the cell (in order to facilitate clinically and statistically significant increases in glutathione levels in BOTH the extracellular serum and intracellular tissues). Because Immunocal® provides the building blocks for cystine, and these building blocks for cystine are easily transported inside the cell where they can be quickly synthesized into glutathione, Immunocal® is therefore ideally suited to increase glutathione levels within the cell.

Q. What is the difference between NAC (N Acetyl L-Cysteine) and Immunocal/HMS90®?

A. N Acetyl L-Cysteine (NAC) is an Antioxidant Drug, which has been demonstrated to facilitate the SHORT TERM cellular detoxification of alcohol, tobacco smoke, acetaminophen [Tylenol®] poisoning and environmental pollutants in several in-vitro (in a test-tube) studies. When Cystine is heated, molecular bonds are cleaved and it becomes Cysteine. Cysteine is beneficial if it is produced INSIDE the cell, but is mildly toxic if it is produced outside the cell. NAC does not travel well in the blood stream, and doesn't reach the cells (to be used to synthesize glutathione and Glutamic acid). NAC supplementation over long periods has been associated with modest increases in serum glutathione, but has not proven particularly useful in the treatment of chronic, long-term intracellular glutathione deficiencies. Furthermore, therapeutic levels of NAC are relatively toxic and have been associated with significant side effects. At therapeutic doses, oral NAC supplementation has been associated with cerebral symptoms: nausea, blurred vision, and vomiting. Immunocal provides the precursors for the manufacture of intra-cellular cystine, and effectively delivers these to the cell. For this reason, Immunocal supplementation has been associated with sustained and significant increases of cellular glutathione, and is virtually devoid of troublesome side effects. Immunocal® has the same side-effect profile as mothers' milk.

Q. What is the difference between bovine colostrum and Immunocal®?

A. The proteins in colostrum have almost no cystine content. Cystine is critically essential to the immune system. Although growth factors present in colostrum (including IGF-1, or Insulin-like growth Factor-1 which is effective in promoting muscle growth) are not affected by stomach acid, research published by one manufacturer of Colostrum (Vital Health News, Winter 1998, page 7) demonstrated that "the effectiveness of the immune factors present in colostrum is lowered by stomach acid." Although the immune enhancing factors found in colostrum are often "preferable to single isolated immune components" (such as interferon, which is more likely to cause troublesome side effects), colostrum has NOT been demonstrated to be superior to isolated undenatured whey proteins such as Immunocal®. Colostrum (which is produced by the mammary glands during the first 26 hours following birth) is primarily composed of immunoglobulin and some lactoferrin. According to both laboratory experiments and clinical trials conducted in Germany, although colostrum supplementation was associated with mild increases in immune function in some patients, these increases were not statistically significant. A postulated mechanism of the action of colostrum is the inter-species transfer of immune factors, however this has NOT been clinically proven. Most of the data supporting the effectiveness of colostrum is anecdotal (consisting mostly of personal testimonies rather than clinical studies). Since the primary mechanism of action on the immune system is via stimulation of the synthesis (production) of glutathione, the near absence of glutathione precursors in the
immunoglobulin fraction (from the colostrum) may explain its relative lack of effect. Conversely, Immunocal contains substantial amounts of thermolabile (heat-sensitive) proteins which are rich in cystine and glutamylcystine (known precursors of glutathione), and the effectiveness of Immunocal has been demonstrated in numerous human clinical trials which found statistically significant increases in glutathione and indices of immune function (such as CD4:CD8 ratios). Colostrum might be beneficial as an adjunctive (add-on) therapy to Immunocal®, but the clinical data is significantly more convincing for Immunocal/HMS90®.

Q. What are some additional benefits of un-denatured whey proteins?

A. Immunocal® has been clinically demonstrated to increase exercise capacity by 13 percent (Lands et al., 1999), and may be useful as a supplement for competitive athletes. Wattanabe et al. (Japan) conducted a clinical study with Immunocal to evaluate increases in GSH among patients with Hepatitis B and C, and found that these viruses are vulnerable to glutathione. In-vitro studies in Japan also showed that whey could stimulate the bone cell (osteoblasts) to produce more bone, hence increasing bone density and reducing the risk of osteoporosis. Lactalbumin from whey protein has been demonstrated to kill breast cancer cells in-vitro. Glutathione (from whey protein) lowers serum cholesterol by stimulating bile synthesis in the liver. In addition, glutathione is a powerful antioxidant that will prevent lipid peroxidation (a sign of free radical activity). Lipid peroxidation is implicated in arteriosclerosis (hardening of the arteries), stroke and coronary artery disease.

Q. How does the manufacturing of our product differ from other whey proteins?

A. In the manufacturing of other whey proteins several things occur: in the process of heating and Pasteurization, critical bonds holding the cystine together get broken down ("denatured", meaning they lose their original nature--similar to the denaturing and irreversible changing of liquid egg white by the heating process involved in frying an egg). The exact type of proteins that serve to increase tissue and serum glutathione most effectively are lost or diminished. The researchers at Immunotec (the manufacturers of Immunocal®) have developed a process by which these delicate proteins remain intact in their natural form to serve us most effectively.

Q. What is the theoretical mechanism of action of GLUTATHIONE (GSH) in Cancer and Immune dysfunction?

A. Natural killer (Immune) cells may become glutathione-depleted over time, and their immune
response weakens. Immunocal raises glutathione levels and strengthens the immune system to fight cancer, viruses, bacteria, etc. For those patients receiving traditional medical therapy for their cancers, Immunocal supplies lactalbumin and has been clinically proven to raise glutathione levels. Glutathione and lactalbumin (a component of Immunocal®) have been associated with the strengthening of healthy cells and (paradoxically) the weakening of cancerous cells. In research conducted by C. Svanborg et al, lactalbumin was associated with apoptosis (or the programmed death) of breast cancer cells. Glutathione has been scientifically demonstrated to decrease cancerous cells' resistance to chemotherapeutic drugs, while protecting healthy cells. This should allow a patient to respond better to chemotherapy with fewer side effects.

Q. What are the diseases or conditions that have been associated with low glutathione levels?

A. There are over 100 diseases and conditions associated with low glutathione levels. Most of the degenerative diseases of aging and the autoimmune diseases have been studied and linked to low GSH levels including: Acetaminophen poisoning, ADD, Addison's disease, aging, AIDS, alopecia areata, ALS, Alzheimer's' disease, anaemia (haemolytic), ankylosing spondylitis, arteriosclerosis (hardening of the arteries), arthritis (rheumatoid), asthma, autism, autoimmune disease, burns, cacexia, cancer, candida infection, cardiomyopathy (idiopathic), Chronic Fatigue Syndrome, colitis, coronary artery disease, cystic fibrosis, diabetes, Crohn's disease, eczema, emphysema, Epstein Barr Viral (EBV) syndrome, fibromyalgia, free radical overload, Graves' disease, hepatic dysfunction (liver disease), hepatitis B, hepatitis C, hypercholesterolemia (high blood cholesterol), herpes, infections (viral, bacterial and fungal), inflammatory bowel diseases (IBD), lupus, macular degeneration (diabetic and age-related macular degeneration), malnutrition, Meniere's disease, multiple sclerosis, Myasthenia Gravis, neurodegenerative diseases, nutritional disorders, Parkinson's disease, primary biliary cirrhosis, progeria, psoriasis, rheumatic fever, sarcoidosis, scleroderma, shingles, stroke, surgery, toxic poisoning, trauma, vasculitis, vitiligo, Wegener's Granulomatosis, to name a few.

Q. Has therapy to increase glutathione levels been effective in treating the diseases or conditions that have been associated with low glutathione levels?

A. Yes. There have been many thousands of research studies proving that raising glutathione levels is an effective treatment in dozens of diseases and conditions. Of course, prevention is always amore desirable path. Immunocal/HMS90 has been proven to raise and maintain healthy levels of glutathione.

Q. Can a person who is lactose intolerant take Immunocal/HMS90®?

A. Yes, Immunocal® has less than 1% lactose which should not cause any ill effect even in the most severe case of lactose intolerance.

Q. Are there any interactions known between supplements such as coenzyme Q-10, antioxidant vitamins, or herbs and Immunocal/HMS90®?

A. No, there are no known potential or reported interactions between Immunocal and nutritional supplements. In fact, Immunocal increases glutathione levels that help to improve the action of antioxidant vitamins (which are less effective if your glutathione levels are impaired). For this reason, mega-doses of antioxidant vitamins (i.e. doses in excess of 10 times the RDA of these vitamins) are not required if you are supplementing with Immunocal®. As we age, our glutathione levels fall precipitously like a downhill ski-slope. Low levels of glutathione are associated with a host of degenerative diseases, and critically low levels of serum and tissue glutathione often predict that death is imminent. Supplementation with Immunocal/HMS90® helps restore these precious glutathione levels, and assists the supplemental vitamins you may be taking to work more effectively.

Q. Are there any interactions known between prescription medications and Immunocal/HMS90®?

A. No, there are no known interactions between Immunocal and prescription drugs. Immunocal is composed of the same basic proteins that are found in human breast milk, and should be considered to be as safe to take as mothers' breast milk. Furthermore, Immunocal® is 90% protein, and is one of the best sources of highly absorbable protein on the planet. Patients taking immunosuppressant drugs such as Cyclosporin® after such treatments as organ transplants should consult their physician before taking Immunocal®.

Q. Are there any side effects associated with Immunocal/HMS90®?

A. Immunocal® increases serum and tissue glutathione levels. When liver tissue glutathione levels rise, the liver is able to more effectively detoxify the body (which is a beneficial function of
Immunocal®). Some patients (especially those who have been exposed to high levels of environmental toxins) may have a mild temporary reaction to these mobilized toxins as the liver is removing them from storage in body fat. Typically, reducing the dose of Immunocal® will allow these temporary side effects quickly disappear. Immunocal is composed of the same basic proteins that are found in human breast milk, and has the same side effect profile as mothers' breast milk. Because Immunocal® is a milk protein, persons who are mildly allergic to milk proteins may experience minor gastric distress from Immunocal®. This gastric distress usually disappears if you reduce the dose of Immunocal®. Persons with serious milk-protein allergies should not take Immunocal®.

Q. Can you overdose Immunocal/HMS90®? Is there any potential for toxicity if you take too much?

A. Your greatest risk is wasting your money if you take "too much" Immunocal®. Clinical data seems to indicate there is limited benefit from exceeding 30 grams (3 packets) per day of Immunocal®. Because our cells have an innate mechanism of "feed-back inhibition" with respect to the glutathione synthesis precursors (building blocks) provided by Immunocal®, there is no potential for making "too much glutathione" within the cell if large quantities of Immunocal® are consumed. Immunocal® supplementation will result in establishment of normal glutathione levels, (NOT excessive glutathione levels) within the cell. Excess Immunocal/HMS90® would be metabolized as protein (Immunocal® is an excellent source of protein, containing 90% protein by dry weight).

Q. Because Immunocal/HMS90® is 90% protein, is it contraindicated in patients on renal dialysis who must limit protein intake?

A. No, Immunocal/HMS90® is not contraindicated in these patients. Although we suggest that you consult your personal physician with individual medical questions such as these, there is no reason to believe that Immunocal/HMS90® would be anything but helpful for these patients. Immunocal® is one of the most easily digested and most easily absorbed forms of protein in the diet. Its Protein Efficiency Ratio (PER: a mark of the quality of a protein) is extremely high, and in conditions such as renal failure where protein intake must be limited, it is most prudent to consume the highest quality proteins such as whey proteins and egg white proteins, versus lower quality proteins that produce more problematic metabolic waste by-products and residues.

Q. Is Immunocal/HMS90® contraindicated in Celiac Sprue disease?

A. These patients are usually instructed not to ingest wheat or gluten. There is no wheat, or gluten in Immunocal. Furthermore, Immunocal® is lactose-free. There is no reason to believe that Immunocal® would be detrimental in patients with Celiac Sprue Disease.

Q. Who should not take the product?

A. People with an allergy specifically to milk protein, (which is very rare). NOTE: Please understand that lactose intolerance is NOT a milk allergy. Also, anyone who has had an organ transplant and is receiving immunosuppressant therapy should not take Immunocal. The immune system needs to be suppressed in order to prevent organ rejection.

Q. What are some of the critical ingredients in a daily amount of Immunocal/HMS90® (1 pouch)?

A. 9 grams or 90% Protein, 0 mg Fat, less than 1% Lactose, 60 mg of Calcium, 4 micrograms of Selenium, 30 Mg of Potassium, 4 mg of Iron, and approximately 40 Calories.

Q. What is the recommended dose for taking Immunocal/HMS90®?

A. Check with your physician or health care professional. If you do not have a documented glutathione deficiency and are taking Immunocal for good health, one pack per day is the usual
maintenance dose. Generally, most studies conducted using Immunocal in patients with glutathione deficiencies used at least 20 grams per day (2 pouches), and some studies showed increased effectiveness using up to 30 grams (3 pouches) per day.

Q. What is the difference in taking Immunocal/HMS90® as opposed to taking other antioxidants?

A. Vitamin E and C are important antioxidants, and you should consider these important supplements in your diet. Immunocal® is not an antioxidant per se, but provides the building blocks for the synthesis of the principle intra-cellular antioxidant, glutathione. Glutathione is the most potent cellular antioxidant known to man, and is hundreds of times more potent than vitamin C or vitamin E. For this reason, glutathione has been called the "Super Antioxidant".

By raising the glutathione level within our bodies we provide for the optimum functioning of other lesser antioxidants such as vitamins C and E. More importantly, glutathione serves as a detoxifying agent for multiple toxins that we encounter on a daily basis through the environment and the medications we take. Glutathione has been demonstrated to act as an effective protectant against ultraviolet radiation, which is important in view of the continued loss of the ozone layer.

Q. What is the best way to mix Immunocal/HMS90®?

A. Because Immunocal is a very fine and delicate powder, we recommend mixing it with any juice or liquid that is not above lukewarm (110 degrees F), and NEVER above 120 degrees F. First, mix the packet with approx. 1 tablespoon of the liquid you have chosen, to form a paste. Then pour the liquid to fill your glass. Allow it to sit for a few minutes, stir, and enjoy. Immunocal can also be mixed in applesauce, yoghurt, or sprinkled over cereal without any particular mixing procedure. The product should not be mixed at high speed in a blender (mechanical mixing damages the milk proteins). If you are making a breakfast “smoothie”, put all the ingredients except the Immunocal/HMS90® into the blender, mix at high speed, then reduce the blender speed to ‘Fold’ or ‘Low’ before adding the Immunocal/HMS90®. You can mix Immunocal by hand, whisk, covered shaker cup or inexpensive "vortex-mixer". We will ship you a portable, battery-operated vortex-mixer FREE with your first shipment of Immunocal® on the Immunocare (Autoship) program (when you sign up using your credit card to receive monthly
shipments of 1 box of Immunocal® or more), or when you purchase a business-builder “Action
Pack".

Q. When is the best time of day to take Immunocal/HMS90®?

A. There is no ‘best time’ to take this product. Because foods such as yoghurt and orange juice are generally morning foods, most people take Immunocal/HMS90® with breakfast. There is nothing wrong with taking it with lunch or dinner or as a midday snack. It will be better absorbed if taken on a relatively empty stomach, i.e. not with or after a heavy meal.
Glutathione (GSH) Enhancer “Glutathione” the body’s most powerful healing agent. (Dr. Jim Gutman, MD) “The human immune system is extremely dependent on adequate glutathione levels to perform properly, in the words of Dr. Wulf Droge former head immunology at the Heidelberg Cancer research institute. "Thiols And The Immune System: Effect of N-Acetyl cysteine on T Cell System in Human Subjects. Even a partial depletion of the intracellular glutathione pool has a dramatic consequence for the process of blast transformation and proliferation, and for the generation of cytotoxic T cells." (T–cells help the body defend against diseases.) Research has shown that we cannot stay healthy with low levels of ‘glutathione. Scientists at McGill University in Canada, discovered a safe, natural way of raising our glutathione levels. The product is “Immunocal”.

Facts about this GSH enhancer, cysteine delivery system

21 Years of research at McGill University Medical Research Center and the Montreal General Hospital
23 Published clinical studies proving its effectiveness
All natural –with no side effects, no conflicts with existing meds
Medicaid/Medicare reimbursement in U.S. in selected states
8 Pharmaceutical type patents in the treatment of numerous very deadly and serious disease states. Proven to raise glutathione levels in your cells.
Listed in the main ‘drug’ edition of the U.S. Physician’s Desk Reference 2004
Exceptional health product for all levels of athletes! Double blind study in Muscle Performance from Montreal Children’s’ Hospital

Main Functions of Glutathione (A I D E )

Anti-oxidant: Glutathione is the body’s own natural anti-oxidant, destroying bad free radicals, while helping anti-oxidants like C & E do more work

Immune Booster: Glutathione raises levels of disease fighting T&B cells

Detoxifier: Glutathione removes heavy metals, toxins & pesticides from the liver. Reduces the negative effects of pharmaceutical drugs on the liver

Energy: Glutathione eliminates bad free radicals, cells produce more energy Immunocal is not a drug, herb, vitamin or anti-oxidant!! It is a highly bioactive (protein) cysteine delivery
system, safe & effective

Doctors Viewpoint on Immunocal/HMS-90

"Almost everyone I put on Immunocal tells me that they feel better as soon as they start taking the product. This is explained by the fact that Immunocal brings to all the cells in our body, the building blocks necessary to produce glutathione, a small protein that each cell needs to function properly. In severe asthmatics taking Immunocal, the attacks become less frequent and less severe. The need for medication is decreased, they sleep better, they don't miss work or school as often, resulting in a better quality of life." Dr. Jean Marcoux, Board Certified Allergist, Immunologist

"Immunocal is the future of the wellness movement - nothing else I know can impact the ability of every cell in the human body to defend itself from the common pathological mechanisms. To raise glutathione levels is to reduce premature oxidation, to eliminate destructive free radicals and help detoxify the poisons inside each cell when it needs to. Only Immunocal is clinically proven to do that in a safe, effective and convenient way." Dr. Allan Somersall

"Current research is uncovering the fact that the underlying culprit in most disease and aging processes is free radical damage and oxidative stress. Therefore, the most reasonable way to combat these degenerative changes is to find a safe and effective way to raise anti-oxidant levels. I have concluded that glutathione is the crucial anti-oxidant. I believe that Immunocal is the safe, effective, and natural way to raise glutathione levels. Taking Immunocal everyday should be a vital component to anybody's proactive health plan." Dr. Tom Iwama

" Immunocal works and it's safe. I believe it is the safest and most effective supplement available to help raise glutathione levels in every cell of your body. GSH or glutathione is the body’s most powerful antioxidant and healing agent. Immunocal itself is not an antioxidant! Also, Immunocal is the best way that I know to support and maintain the immune system. This is especially important at a time when medicine is beginning to recognize how many diseases are caused by a deficiency of the immune system. But that's not the whole story - just as important, are the people behind the product. Everyone at Home Office is of the highest integrity. As a doctor, I appreciate the power and efficacy of Immunocal. As a person, I enjoy being associated with dedicated and delightful people." Dr. Tom Kwyer

Immunocal Amino Acid Profile Review

As a nutritional chemist, PHD and a certified Sports Performance coach with over 2 decades of experience working with a wide variety of athletes including elite World and Olympic medalists, Dr. Theadoro was very impressed upon reviewing the amino acid profile of Immunocal. It has been our experience working with these athletes, and is well documented, that exercise exerts a huge systemic demand for amino acids on the human body. Many studies, such as Lemon at Kent State University, have demonstrated that certain amino acids are consumed much faster than others during even moderate exercise. L-glutamine, in particular, is known to be the most abundant amino acid in muscle tissue and shows the highest blood concentration of all the amino acids after an exercise session. Immunocal supplies almost 1.8 grams of L-glutamine/glutamate in one pouch!

Also, the three branched chain amino acids (BCAAs), L-leucine, L-isoleucine and L-valine, are absolutely fundamentally necessary for the maintenance, repair and growth of lean, functional muscle tissue, are available in a high percentage in Immunocal/HMS-90. Young at MIT showed that L-leucine oxidation is increased by 240 % during even moderate exercise!

Immunocal provides almost one gram of L-leucine in one pouch! The total amount of the three BCAAs in one pouch of Immunocal is over 2.2 grams! Knowing the superb bioavailability of Immunocal to human beings and the excellent profile of Immunocal, particularly with respect to the aforementioned amino acids, it should be obvious to any athlete and coach that supplementing with Immunocal will greatly aid recovery from workouts and help any athlete achieve his or her goals, safely, legally and effectively.

• Immunocal is a bioactive whey protein nutraceutical,cystine delivery system that supports the immune system, raises T cell levels and detoxifies the liver.
• It is rich in cysteine-cysteine and glutamyl-cysteine dipeptides.
• It supplies about 1.8 grams of L-glutamine/glutamate per serving.
• It supplies almost 2.2 grams of the essential branched chain amino acids, including 1 gram of L-leucine, per serving.
• It contains <1% style="text-align: center;">The Safety of Immunocal

Immunocal is a broad-spectrum nutraceutical food derivative with biologic capability to modulate cellular function. More than 100,000 people have used Immunocal with no significant adverse side effects.

Production of Immunocal meets or exceeds the requirements of the USDA for dairy products.
The total bacterial count is less than 1000/g with no detectable pathogens and/or antibiotics.
The whey protein concentrate (WPC) marketed as Immunocal has been tested in hundreds of laboratory experiments on mice (20% in formula diets) from 1980 to 1992 without any signs of toxicity.
WPC fed mice were not distinguishable from controls, in terms of growth rate, hair appearance, serum protein, etc. 1-8 Immunocal has also been administered in clinical trials in adults and children in doses varying from 10/g to 40/g per day without side effects. 9-12

In addition, Immunocal is sold in Canada, United States, Europe, Japan, Malaysia, Taiwan and other
countries to thousands of customers and no clinically relevant complications have been reported.
* 21 Code of Federal Regulations §184.1979c affirms whey protein concentrates as GRAS and the FDA has determined there
are no questions regarding safety for human consumption.
REFERENCES
1. Bounous G, Stevenson MM, Kongshavn PAL. Influence of dietary lactalbumin hydrolysate on the immune system of mice and resistance to Salmonellosis. J Infect Dis 144: 281, 1981.
2. Bounous G, Letourneau L, Kongshavn PAL. Influence of dietary protein type on the immune system of mice. J Nutr 113: 1415-21, 1983.
3. Bounous G, Kongshavn PAL. Influence of protein type in nutritionally adequate diets on the development of immunity. In: Absorption and Utilisation of Amino Acids. M. Friedman (Ed.). Boca Raton, Florida: CRC Press, vol. 2, 219-32, 1989.
4. Bounous G., Batist G, Gold P. Immunoenhancing property of dietary whey protein in mice: role of glutathione. Clin Invest Med 12: 154-61, 1989.
5. Bounous G, Shenouda N, Kongshavn PAL, Osmond DG. Mechanism of altered B-cell response induced by changes in dietary protein type in mice. J Nutr 115: 1409-17, 1985.
6. Bounous G, Papenburg R, Kongshavn PAL, Gold P., Fleiszer D. Dietary whey protein inhibits the development of dimethylhydrazine-induced malignancy. Clin Invest Med 11: 213-7, 1988.
7. Papenburg R, Bounous G, Fleiszer D, Gold P. Dietary milk proteins inhibit the development of dimethylhydrazine-induced malignancy. Tumor Biol 11: 129-136, 1990.
8. Bounous G., Batist G., Gold P. Whey proteins in cancer prevention. Cancer letters 57, 91-94, 1991.
9. Bounous G, Baruchel S, Falutz J, Gold P. Whey proteins as a food supplement in HIV seropositive individuals. Clin Invest Med 16: 204-209, 1993.
10. Baruchel S, Viau G, Olivier R, Bounous G, Wainberg M.A. – Nutriceutical Modulation of Glutathione with a Humanised Native Milk Serum Protein Isolate, Immunocal®.
11. Application in AIDS and Cancer. In: Oxidative Stress in Cancer, AIDS, and Neurodegenerative Diseases. Ed. L. Montagnier, Olivier R., Pasquier C. Publ Dekker M., New York, 447-461, 1998.
12. Lands L, Grey VL, Smountas AA. The Effect of Supplementation with a Cysteine Donor on Muscular Performance. Journal of Applied Physiology Vol. 87: 1381-1385, 1999.
13. Lotian B, Grey V, Kimof RJ, Lands L. Treatment of Obstructive Airway Disease with a Cysteine Donor Protein Supplement: A Case Report. Chest; 117: 914-916, 2000.

Consumer Lab Certified

noreply@blogger.com (Dave) — Mon, 18 Feb 2008 21:06:00 +0000

Immunocal has been tested as part of ConsumerLab.com's Athletic Banned Substance Screening Program which screens for over 170 substances (including metabolites) based on the 2007 World Anti-Doping Code Prohibited List and has been certified free of any prohibited substances. The screening includes testing for stimulants, narcotics, anabolic agents, diuretics, masking agents and beta blockers based on the Olympic Movement Anti-Doping Code or the codes of other sports organizations. Click to view Immunocal on ConsumerLab.com's website.

For purposes of this testing, ConsumerLab.com acquired product through an independent representative, ensuring that product tested was randomly selected from a specific lot. Lot number for the testing was A3030731L, with an expiry date of 2009. To pass, a product must contain no confirmed Banned Substance at a "zero-tolerance level".

ConsumerLab.com reserves the right to disqualify a product at any time from passing its testing if it considers such product to present a safety risk or to provide misleading or inaccurate information. Athletes have long included Immunocal in their training regimens based on its scientific validation.

Studies such as that by Dr. Larry Lands on the "Effect of supplementation
with a cysteine donor on muscular performance" show that Immunocal can be an effective part of the athlete's nutritional supplementation.

President and Chief Executive Officer, Jim Northrop underlines that this latest substantiation of Immunocal's safety reinforces Immunotec's commitment to providing the public with the highest integrity nutritional supplementation available.

Immunocal has numerous North American and International patents, is listed in the Physicians' Desk Reference, the Pharmacist's Red Book and is approved for Medicare/Medicaid coverage in the U.S. Immunocal/HMS 90® has regulatory approval and a Natural Product Number from Health Canada as a natural source of the glutathione precursor cysteine for the maintenance of a strong immune system.

Immunocal vs. NAC

noreply@blogger.com (Dave) — Sat, 09 Feb 2008 22:56:00 +0000

RAISING GLUTATHIONE USING CYSTEINE

Enhancement of glutathione levels through cysteine supplementation has proven and important health benefits. But consumers have questions about the best available source of cysteine. Immunotec provides the answer.

IN SEARCH OF THE BEST STRATEGY FOR CYSTEINE SUPPLEMENTATION

By Dr. Wulf Dröge, Senior Vice-President, Research and Development

A series of clinical studies and complementary laboratory experiments has shown that aging is associated with a progressive decrease in plasma cysteine and intracellular glutathione concentrations. This decrease leads to (and can be viewed as a manifestation of) age-related oxidative stress. Cysteine and glutathione concentrations are particularly low during the night and early morning hours, i.e. during periods of starvation.

Several clinical studies have also shown that cysteine supplementation on top of the regular diet ameliorates several aging-related processes and improves amongst other parameters skeletal muscle functions and infl ammatory cytokine levels. Most of these studies have been performed with N-acetylcysteine (NAC). This was the best choice for this purpose because the free amino acid cysteine is not very stable and cysteine-rich proteins such as IMMUNOCAL® contain various different amino acids and would not have been helpful in studies designed to identify cysteine as the most important amino acid in this context.

The search for the best strategy to supply additional amounts of cysteine to the average consumer is now raising a very different and practical question. Not surprisingly the answer is different.

Let us compare NAC with IMMUNOCAL®.

NAC has some adverse effects which are not shared by IMMUNOCAL® and which render NAC unattractive as a source of cysteine over long periods of time. In addition, there are studies to suggest that dietary cysteine from any source is converted within the blood into its less accessible derivative cystine and within the liver into its breakdown product sulfate unless it is rapidly cleared from the blood by protein synthesis in skeletal muscle and other tissues. The undenatured whey protein IMMUNOCAL® provides all protein-forming amino acids and is known to stimulate rapid protein synthesis within less than 2 hours. This process allows the body to store cysteine until it is recovered by regulated protein breakdown during periods of starvation, i.e. during the night and early morning hours. IMMUNOCAL® is clearly superior to NAC in stimulating this process of cysteine storage.

Dr. Wulf Dröge, Ph.D. - A world-renowned research scientist, Dr. Dröge has devoted more than forty years to basic and clinical research that form the basis for the design of safe, effective new immunotec products. Published over 260 times in peer-reviewed publications Postdoctoral fellowships at the Max Planck Institute and Harvard University Professor, Faculty of biology, University of Heidelberg and Head of the department of Immunochem., German Cancer Research Center. He continues to write articles and teach at McGill University & Research Development

IMMUNOCAL®. Accept no substitutes. Immunotec®

CYSTEINE, N-ACETYLCYSTEINE (NAC), AND IMMUNOCAL®

By Dr. Jimmy Gutman, Medical Consultant Research over the past quarter century has shown that the limiting factor for our body's ability to make glutathione, is the availability of cysteine in our diet. There are several options, let's look at cysteine itself, N-acetylcysteine (NAC) and IMMUNOCAL®.

The amino acid cysteine can be found in supplement form in pills and powders. Unfortunately just eating cysteine has not proved to be an effective way to raise glutathione. Cysteine alone is quickly oxidized in the digestive system and does not make it to the cells in an appreciable quantity. Cysteine must be in a form that can survive the trip through the gut, into the bloodstream and across the cell membrane.

NAC is a form of cysteine that has been chemically modified to be able to make this long journey from your mouth to your cells. NAC is used as a drug to raise glutathione in critical medical situations such as acetaminophen overdose. It is also the drug most commonly used in research studies investigating glutathione augmentation. NAC suffers from two drawbacks. It is effective in raising glutathione only for a short few hours, which is why doctors must give it to patients throughout the entire day. Individuals who take NAC pills experience a peak in glutathione and then levels may crash, occasionally below baseline values. The other complication of NAC is that side effects such as nausea, vomiting and diarrhea are common.

After years of investigation, Dr. Gustavo Bounous developed what we know as IMMUNOCAL®. This is a protein supplement that has the ability to deliver cysteine to our cells. It can be viewed as a "cysteine delivery vehicle". Being a complicated natural protein, the transformation of cysteine into glutathione starts quickly, but continues over many hours as our digestion and metabolism do their job. Side effects from IMMUNOCAL® are very rare.

It must be kept in mind that the amount of cysteine in IMMUNOCAL® is not as important as the form of ysteine. For example, if you were to boil IMMUNOCAL®, the amount of cysteine would remain the same, but the ability to raise glutathione would be destroyed, because the cysteine would no longer be in a deliverable form for the cell to properly utilize.

The advantages of IMMUNOCAL® over cysteine and NAC are clear once the physiology is understood. Glutathione molecule and structure

The Leading Cause of Death may Surprise you!

noreply@blogger.com (Dave) — Tue, 05 Feb 2008 14:28:00 +0000

Some interesting statistics that may interest you regarding the leading cause of death in North America.

Statistically nearly 1/2 of all deaths in North America are the result of Coronary Disease (Heart and Stroke)
1 of every 2.6 women in North America will die of heart related diseases
Only 15% of heart attacks are because of blockages

85% of heart attacks are because of inflammation

There is an inexpensive test called CRP (C- Reactive Protein) that will tell you the risk you have of having a heart attack.

If your test results are: 3+ you are a walking heart attack, 2 or less – at risk, 1-1.5 – moderate risk, .5 or less – almost never have heart attack or stroke

Make a list of 40 people you know - that you care about.

Nearly half of them will die of heart related disease!

Immunocal Platinum gets rid of inflammation. There are no other natural products that will reduce inflammation like Immunocal Platinum.

Alternately: It is expected that in North America $105 B in sales in non-steroidal anti-inflammatory drugs by 2012. Celebrex will be the prescription drug of choice.

Celebrex side effects

Gastrointestinal Abdominal: pain, Diarrhea, Dyspepsia, Flatulence, Nausea

Body as a whole: Back pain, Peripheral edema, peripheral nervous system, Dizziness, Headache

Psychiatric: Insomnia,

Respiratory: Pharyngitis, Rhinitis, Sinusitis, Upper respiratory tract infection

Skin: Rash

Immunocal Platinum side effects:

No side effects (initial detoxification may occur), no interaction with prescription drugs.

Those taking anti-rejection drugs due to organ transplant; or those with true milk protein allergies must consult their doctor before taking HMS90 or Platinum. Immunotec has made application to make the claim that Platinum is effective in reducing inflammation.

Now, go back to that list of 40 people you care about. Based on today’s statistics, 20 of them will die of heart related diseases. When do you start sharing this information with them?

Want More Details on Immunocal Platinum?

Can We Cure Aging?

noreply@blogger.com (Dave) — Tue, 05 Feb 2008 02:14:00 +0000

Controlling inflammation could be the key to a healthy old age.

by Kathleen McGowan

12.04.2007

Jim Hammond is an elite athlete. He works out two hours a day with a trainer, pushing himself through sprints, runs, and strength-building exercises. His resting heart rate is below 50. He’s won three gold medals and one silver in amateur competitions this year alone, running races from 100 to 800 meters. In his division, he’s broken four national racing records. But perhaps the most elite thing about Hammond is his age.

He is 93. And really, there’s nothing much wrong with him, aside from the fact that he doesn’t see very well. He takes no drugs and has no complaints, although his hair long ago turned white and his skin is no longer taut.

His secret? He doesn’t have one. Hammond never took exceptional measures during his long life to preserve his health. He did not exercise regularly until his fifties and didn’t get serious about it until his eighties, when he began training for the Georgia Golden Olympics. “I love nothing better than winning,” he says. “It’s been a wonderful thing for me.” Hammond is aging, certainly, but somehow he isn’t getting old—at least, not in the way we usually think about it.

They say aging is one of the only certain things in life. But it turns out they were wrong. In recent years, gerontologists have overturned much of the conventional wisdom about getting old. Aging is not the simple result of the passage of time. According to a provocative new view, it is actually something our own bodies create, a side effect of the essential inflammatory system that protects us against infectious disease. As we fight off invaders, we inflict massive collateral damage on ourselves, poisoning our own organs and breaking down our own tissues. We are our own worst enemy.

This paradox is transforming the way we understand aging. It is also changing our understanding of what diseases are and where they come from. Inflammation seems to underlie not just senescence but all the chronic illnesses that often come along with it: diabetes, atherosclerosis, Alzheimer’s, heart attack. “Inflammatory factors predict virtually all bad outcomes in humans,” says Russell Tracy, a professor of pathology and biochemistry at the University of Vermont College of Medicine, whose pioneering research helped demonstrate the role of inflammation in heart disease. “It predicts having heart attacks, having heart failure, becoming diabetic; predicts becoming fragile in old age; predicts cognitive function decline, even cancer to a certain extent.”

The idea that chronic diseases might be caused by persistent inflammation has been kicking around since the 19th century. Only in the past few years, though, have modern biochemistry and the emerging field of systems biology made it possible to grasp the convoluted chemical interactions involved in body wide responses like inflammation. Over a lifetime, this essential set of defensive mechanisms runs out of bounds and gradually damages organs throughout the body.

When you start to think about aging as a consequence of inflammation, as Tracy and many prominent gerontologists now do, you start to see old age in a different, much more hopeful light. If decrepitude is driven by an overactive immune system, then it is treatable. And if many chronic diseases share this underlying cause, they might all be remedied in a similar way. The right anti-inflammatory drug could be a panacea, treating diabetes, dementia, heart disease, and even cancer. Such a wonder drug might allow us to live longer, but more to the point, it would almost surely allow us to live better, increasing the odds that we could all spend our old age feeling like Jim Hammond: healthy, vibrant, and vital. And unlike science fiction visions of an immortality pill, a successful anti-inflammatory treatment could actually happen within our lifetime.

For the last century and a half, the average life span in wealthy countries has increased steadily, climbing from about 45 to more than 80 years. There is no good reason to think this increase will suddenly stop. But longer life today often simply means taking longer to die—slowly, expensively, and with more disease and disability. “If you talk to many old people, what they are really desperate about is not the fact that they’re going to die but that they are going to be sick, dependent, have to rely on others,” says Luigi Ferrucci, chief of the longitudinal studies section at the National Institute on Aging and director of the Baltimore Longitudinal Study of Aging, the nation’s longest-running study of old age.

Biologists have known for a while that inflammation increases with age, but until recently, given everything else that slumps, spikes, or goes off the rails as we get old, it didn’t seem especially important. Some researchers on aging still think that way.

But a big clue linking inflammation with aging came in the late 1990s, when Tracy and his colleagues showed that C-reactive protein (CRP), an inflammatory protein, is an amazingly accurate predictor of a future heart attack—as good as or better than high blood pressure or high cholesterol. At least in heart disease, inflammation isn’t just a bystander. What’s more, we could do something to decrease it. Aspirin, which was already known to help people with heart disease, seems to work primarily by reducing inflammation.

So why should our own immune system rely on such an apparently dangerous mechanism? The answer lies in the fact that infectious disease has historically been the number one killer of human beings, and responding to this threat has profoundly shaped our biology. Possessing a fierce and ferocious immune response primed to keep us alive long enough to reproduce was an evolutionary no-brainer.

Damage to the joint from sever arthritic inflammation often requires a hip replacement.

Inflammation is what gives us that response. It serves as all-purpose protection against invaders and traumatic damage. To take a simple scenario, suppose you are bitten by a cat. First, coagulation factors promote clotting in order to stanch bleeding and prevent germs from spreading from the wound site. A menagerie of phagocytes, which swallow and destroy pathogens, surge out of the bloodstream and squeeze into the affected tissue, engulfing bacteria and secreting cytokines—messenger proteins that send out the call for more responders. The phagocytes also generate reactive oxygen species, unstable compounds that chew up bacteria as well as damaged human tissue.

At the same time, other switches get flipped throughout the body, modifying everything from metabolism to cell growth, via other cytokines, such as IL-6 and tumor necrosis factor–a, and things like CRP, which mark bacteria for destruction. The specialized adaptive immune response eliminates any remaining germs.

So far, so good. But the inflammation response can kick in even when there’s no invader. Atherosclerosis, or hardening of the arteries, is a classic example. In response to fatty deposits on the walls of the arteries, a type of phagocyte called a macrophage identifies the growing lesions as trouble spots and infiltrates them, swelling and destabilizing the deposits. Those lesions can then break open, resulting in the formation of a blood clot that can clog blood vessels and cause heart attacks. The more active the macrophages are, the more CRP is in the bloodstream, and the more likely the lesions will break open, block your arteries, and kill you.

The evidence that inflammation is behind other diseases is indirect, but it is mounting. Researchers have long known that in patients with Alzheimer’s, the areas of the human brain clogged with senility-associated plaques also bristle with inflammatory cells and cytokines. Modern research has found that cytokines block memory formation in mice. In diabetes, inflammation and insulin resistance apparently track together, and drugs that effectively restore insulin sensitivity also appear to reduce inflammatory factors like IL-6 and CRP. Inflammation is also being investigated by a group at Leiden University in the Netherlands as a culprit in declining lung function, in osteoporosis, and in old-age depression. Even the weakness of old age may have an inflammatory cause: Ferrucci has found that inflammatory activity breaks down skeletal muscle, leading to the loss of lean muscle mass. Being fat makes all these diseases strike earlier, and that seems to be at least in part because fat cells spur more inflammation.

These findings have provided researchers with a totally new appreciation of how subtly inflammation can work and how wildly awry it can go over time. It’s not about “a massive infection or a welt the size of an egg because you got hit in the head with a two-by-four,” Tracy says. “Inflammation also goes on at a much lower level.” As it simmers in the background, over years and decades, collateral damage accumulates—in the heart, in the brain, everywhere. Harvey Jay Cohen, chairman of the department of medicine and director of the Center for the Study of Aging at Duke University Medical Center, likens inflammation to “little waves lapping on the shore. It’s a relatively low level of activity, one that sustained over time wears away at the beach and stimulates other bad events.”

Evolution has designed into us a cruel trade-off: What saves us in the short term kills us over the long haul. As we get older, acute episodes of inflammation tend to turn into chronic ones, perhaps because the regulation of the immune system becomes less efficient. Inflammatory factors in the blood can increase two- to fourfold. Chronic infections may be partly to blame. Although we usually don’t know it, nearly all adults are infected with the Epstein-Barr virus, and at least 60 percent of us with cytomegalovirus. These two pathogens can stay in our bodies in a latent state, hiding out in our cells. But Ronald Glaser, a viral immunologist at Ohio State University Medical Center and his research partner (and wife), psychologist Janice Kiecolt-Glaser, think that these viruses are not fully dormant. They’ve found evidence (pdf) that with age, antibodies to these viruses increase, indicating a reawakened virus and an active immune response.

Early experiences may also influence the way that inflammation affects an individual’s aging, says Caleb Finch, a neurobiologist and gerontologist at the University of Southern California. Analyzing historical birth and death records from 19th-century Europe, he and Eileen Crimmins, a gerontologist and sociologist at the University of Southern California, found that longevity is directly related to exposure to childhood disease. Children born during years of high neonatal mortality who survived to adulthood didn’t live as long as those born in healthier years. The reason, he says, is inflammation: A high infectious burden in childhood results in a high inflammatory burden in adulthood, which results in a shorter, sicker life. Conversely, Finch believes that people in affluent countries now live so long because their childhoods are free from diseases like measles, typhoid, malaria, whooping cough, and worms. Without these diseases, people grow bigger and stronger—and live much longer.

Looking beyond provocative findings like those in Finch’s study, Tracy and other researchers on aging say that it may be too simplistic to think of inflammation in terms of straightforward cause and effect. Instead we must think of human biology as a group of interdependent systems. “Is inflammation a response to aging, or is it causing aging or disease?” Tracy asks. “My answer is: Yep, yep, yep. It does all those things. There’s no other way to think about it—it’s both cause and response to what’s going on.”

Inflammation is not uncontested as a theory of aging. There are many competing hypotheses. Yet inflammation reinforces some more than others, potentially establishing a plausible constellation of mechanisms responsible for aging.

For example, according to the “free radical” hypothesis of aging, we get older because of constant cellular damage caused by reactive oxygen compounds that are a natural product of metabolism. Inflammation can partly explain how this might work. Macrophages, as part of the inflammatory response, produce reactive oxygen species in order to attack bacteria. Oxidative stress and inflammation clearly egg each other on, and calming one can inhibit the other.

To take another prominent example, a low-calorie diet is known to increase the life spans of creatures ranging from flatworms to rats, but no one knows why, or whether it will help humans live longer. Inflammation provides a clue: Dietary restriction sharply inhibits the inflammatory response, and that may be part of why it promotes longevity at the same time that it reduces insulin resistance and slows dementia. Yet another widely discussed theory of why we age blames the shortening of telomeres, chromosomal structures that, in most cells, dwindle with each division and may ultimately limit the number of times any cell can divide. It is possible that inflammation could play a role here, too, because it prompts the faster turnover of cells in the immune system and other tissues.

Still, nobody thinks that there is a single root cause of aging—different species may age in different ways, and multiple mechanisms are probably at work. “I think it would be a mistake to suggest that inflammation is the cause of aging, or that all theories of aging must be tied to it,” Cohen says. Then again it may not ultimately matter whether inflammation is the most significant cause of our decay. More important is that inflammation offers an unparalleled opportunity to do something about it.

Some ways to reduce inflammation are elementary. It is impossible to know exactly what is going on in Jim Hammond’s body, but all the aspects of his regimen—healthy food, exercise, and a good attitude—reduce systemic inflammation. Those of us without his tenacity can turn to drug companies, which are exploring new anti-inflammatory drugs like flavonoids. Researchers are also looking at new uses for old drugs—trying to prevent Alzheimer’s using ibuprofen, for example. “The research is really to prevent the chronic debilitating diseases of aging,” says Nir Barzilai, a molecular geneticist and director of the Institute for Aging Research at the Albert Einstein College of Medicine in New York. “But if I develop a drug, it will have a side effect, which is that you will live longer.”

Some of this research stretches the boundaries of what we know. Rudi Westendorp, head of the department of gerontology and geriatrics at the Leiden University Medical Center, is trying to treat old-age depression with drugs that are currently used for autoimmune conditions like rheumatoid arthritis. Harvard University researchers are considering a vaccine against atherosclerosis, which may provoke a reaction that suppresses inflammation.

The caveat with these experiments is that by modifying inflammation, we are playing with fire. After all, fighting off infection is an absolutely essential bodily function. “The danger of monkeying around in a system like that is that you may do more harm than good,” Cohen says. But humans appear willing to renegotiate the ancient evolutionary bargain that traded robust reproductive health for frail old age.

Think of Jim Hammond if you have any doubts. In his blog, he describes running the 800-meter race in the 2007 National Senior Olympics games. “I won in a photo finish, and I broke the national record,” he wrote. The crowd went nuts. At the age of 93, Hammond had the most exhilarating experience of his entire life.

New Cancer Study Results are in.

noreply@blogger.com (Dave) — Fri, 18 Jan 2008 01:49:00 +0000

Cysteine-rich protein reverses weight loss in lung cancer patients receiving chemotherapy or radiotherapy.

Tozer RG, Tai P, Falconer W, Ducruet T, Karabadjian A, Bounous G, Molson JH, Dröge W.

Hamilton Regional Cancer Centre, Hamilton, Ontario.

Cysteine-Rich Protein Prevents Weight Loss in Lung Cancer Patients:

A Promising Intervention Study

MONTREAL, Jan. 17, 2008 /PRNewswire-FirstCall/ - Immunotec Inc. (TSX-V: IMM) announced today the successful completion of a multi-center randomized, double-blind clinical trial on cancer-related weight loss (cachexia) in lung cancer patients which was performed in collaboration with various Canadian clinical centers (x) . The research concluded that patients treated with IMN 1207 showed significant increases in body weight (Tozer et al.Antioxidants & Redox Signaling (2008) 10:395-402). Immunotec also announced the initiation of a follow-up study to confirm the positive results.

The massive loss of body weight and muscle mass in advanced cancer patients is typically associated with psychological stress, financial burden and a decreased quality of life. Until now there have been no dietary interventions known to satisfactorily prevent this process.

Immunotec's new study included 66 patients with advanced lung cancer receiving state of the art chemotherapy or radiotherapy. The patients had already suffered significant involuntary weight- loss prior to treatment. During a six month treatment period the patients were given either casein, a protein supplement low in cysteine which is widely used in clinical nutrition ("placebo") or IMN 1207, a specially-prepared glutathione enhancing cysteine-rich whey protein isolate supplied by Immunotec Inc. The results showed that patients in the placebo group continued to lose weight whereas patients treated with IMN 1207 showed a significant increase in body weight. Incidentally, these patients also showed an increase in strength and quality of life parameters. This study showed for the first time that cancer-related weight loss (cachexia) can be prevented by a single source of protein. Dr. Gerald Batist, Chair, Department of Oncology, McGill University stated "Having been involved in the early mechanistic studies of the therapeutic use of whey proteins, I'm pleased to see this particular formulation being tested in the clinic. The data to date encourage additional and expanded clinical trials". Dr. Wulf Droge, Senior Vice-President Research & Development at Immunotec Inc. emphasized that the results of this first trial should be viewed with cautious optimism. A second trial has been initiated to confirm the results.

Among other questions, this clinical trial also addressed the controversy about antioxidant use in chemotherapy. Since radiotherapy and many types of chemotherapy work by raising levels of oxidative stress and free radical formation to destroy cancer cells, oncologists have voiced concern that treatment of the patient with antioxidants may "protect" the cancer from the toxic effects of the therapy. If this were the case, antioxidants could even be expected to shorten the life span of the patients. Immunotec's study now showed that this was clearly not the case with IMN 1207. Based on his earlier work at his laboratory at the National Cancer Research Center of Germany (DKFZ) in Heidelberg, Dr. Droge was reasonably confident that supplementation with a critical precursor of the major cellular antioxidant glutathione, would actually improve the condition of the patients, most probably by ameliorating adverse effects of these therapies on the patients' healthy tissues. The results of this new study suggest that this is true. The antioxidant glutathione is distinct from other antioxidants including the popular antioxidant vitamins A, C, and E which are widely used as nutritional supplements. Glutathione is involved in the removal of reactive oxygen species and other potential toxic compounds through special biochemical processes and can reach relatively high and beneficial concentrations in cells and tissues depending on the availability of its biosynthetic precursor cysteine.

About IMN 1207 from Immunotec Research (Immunocal plus)

IMN 1207 is a cysteine-rich protein. It is the research formulation of the undenatured whey protein Immunocal(R)/HMS 90(R), a dietary natural health supplement, developed and marketed worldwide by Immunotec during the past 12 years. Immunocal(R)/HMS 90 is a precursor of the major cellular antioxidant glutathione, an element important in maintaining a strong

immune system.

About Immunotec Inc.

Immunotec is engaged primarily in the development and marketing of natural health products, dietary supplements, food, vitamins and personal care products, many of which are manufactured on its behalf by third parties. Immunotec's products are distributed and sold in Canada and the United States through a network marketing system and in other countries through exclusive distributorship agreements. Immunotec's investment in this study is another manifestation of its ongoing commitment to research and development. http://www.immunotec.com.

x Montreal General Hospital (McGill University teaching hospital) Montreal , Quebec , Canada

x Cross Cancer Institute, Alberta Cancer Board (University of Alberta affiliate) Edmonton , Alberta Canada

x Jewish General Hospital (McGill University teaching hospital) Montreal Quebec,Canada

x Juravinski Cancer Centre (McMaster University and Hamilton Health Sciences affiliate) Hamilton , Ontario,Canada .

x Allan Blair Cancer Centre (a division of Saskatchewan Cancer Foundation) Regina , Saskatchewan , Canada .

PMID: 18158761 [PubMed - in process]

See the actual report:

http://www.liebertonline.com/doi/pdfplus/10.1089/ars.2007.1919

For more information on Immunocal go to www.3MinuteDecision.com/dharnaha

Natural Treatment for Gout

noreply@blogger.com (Dave) — Tue, 15 Jan 2008 04:02:00 +0000

Montmorency Tart Cherry

Not only are Montmorency tart cherries high in melatonin which is a natural Glutathione Booster, but they are Good for Gout too.

Gout is a form of arthritis that is caused by the build-up of a substance found in the body called uric acid. This acid is used by the body to break down a common substance in many different foods known as purines.

When people suffer from gout, the uric acid that has built up in their system begins to form jagged crystal-like formations in the blood stream. It is these painful little crystals that cause the horrible swelling and pain that gout is known for. But what causes the uric acid build up and how do you know if you're having a gout attack?

The causes of gout attacks can be attributed to many different things. Foods high in purines are a common culprit. Things like salmon, seafood and alcohol. Also, offal meats (parts of animals we eat other than muscle, like liver and kidney's) are suspected of causing gout because of their high purine content.

For reasons unknown to doctors, about 75% of gout sufferers' first start to feel an attack in the joint of the big toe. Other likely joints that might signal a gout attack are the ankle, knee or elbow.

The pain associated with gout comes from two different sources. There is the sharp, stabbing pain caused by the crystals that get caught in the toe joint, as well as the pain caused by the swelling and inflammation of the tissues around the joint.

Gout has four stages that a sufferer could end up going through if the condition is left untreated. The first is asymptomatic, which simply features rising levels of the sinister uric acid rising in the blood stream, but before any symptoms manifest.

The second is acute gout, which features a person's first gout attack, most of which go away quickly and there isn't a frequent reoccurrence. Remember, the sooner you get treatment, the sooner the pain will go away. The average case of gout lasts only a day or two with proper care.

The third stage of gout is intercritical, which is just the symptom-free time between attacks, and the fourth and final stage of gout is the chronic stage. Chronic gout is made up of multiple bouts of the disease and the gout attacking more than one joint at once.

If gout isn't treated properly, serious health problems can arise, such as kidney damage and the formation of kidney stones, as well as hypertension (high blood pressure).

While there is no "cure" for gout in the traditional sense, since the disease can return anytime there is an imbalance in your body's uric acid levels, there are many different treatments and you can effectively eliminate the risk of gout through natural means.

Most doctors prescribe a change in diet from foods high in purine to foods that help the body absorb excess uric acid in the blood stream. Most berries and fruit are great at absorbing uric acid, whereas foods high in protein, such as chicken or even tofu should not be eaten at all during a flare up since it is believed those foods make matters worse.

In conclusion, even though gout is associated with a period in history long gone when knights on horseback were busy saving fair maidens, it is very much an ailment of today's world. But with the proper diet and early diagnosis, the horrible pain of gout can be controlled.

To learn more take a video tour at 3 Minute Decision.

More on Detoxification

noreply@blogger.com (Dave) — Sat, 12 Jan 2008 17:43:00 +0000

Glutathione and Detoxification

The glutathione system is the body's primary detoxification mechanism and, as such, is responsible for the removal of toxic compounds from the body, regardless of their etiology. Heavy metals, pharmaceuticals, insecticides, cigarette toxins, air and water pollutants - just to name a few. If your body's intracellular glutathione level is not optimized, it logically follows that cellular damage will result. The cumulative damage caused by the relentless onslaught of environmental toxins defines the very process of aging and disease.

The following abstracts contain overviews of studies performed that demonstrate glutathione's role in detoxification. Click on the corresponding link (blue) to read the abstract as found on the National Institute of Health's government website:

Cysteine metabolism and metal toxicity
Quig D. [Altern Med Rev 1998 Aug;3(4):262-70] The pro-oxidative effects of metals are compounded by the fact that the metals also inhibit antioxidative enzymes and deplete intracellular glutathione. Cysteine has a pivotal role in inducible, endogenous detoxication mechanisms in the body, and metal exposure taxes cysteine status. Basic research pertaining to the transport of toxic metals into the brain is summarized, and a case is made for the use of hydrolyzed whey protein to support metal detoxification and neurological function. Early detection and treatment of metal burden is important for successful detoxification, and optimization of nutritional status is paramount to the prevention and treatment of metal toxicity.

Mechanism of action and value of N- acetylcysteine in the treatment of early and late acetaminophen poisoning: A critical review.
Jones AL. [Journal of Toxicology -- Clinical Toxicology. 1998; volume 36, number 4, pages 277-285] The mechanism of action of N-acetylcysteine in early acetaminophen poisoning is well understood, but much remains to be learned of the mechanism of its possible benefit in acetaminophen poisoning presenting beyond 15 hours. Candidate mechanisms for a beneficial effect in-clude improvement of liver blood flow, glutathione replenishment, modification of cytokine production, and free radical or oxygen scavenging.

Glutathione deficiency in alcoholics: risk factor for paracetamol hepatotoxicity.
Lauterburg BH and Velez ME. [Gut. 1998; volume 29, pages 1153-1157]. "The data indicate that low glutathione may be a risk factor for [acetaminophen] hepatotoxicity in alcoholics because a lower dose of [acetaminophen] will be necessary to deplete glutathione below the critical threshold concentration where hepatocellular necrosis starts to occur."

Chronic ethanol and nicotine interaction on rat tissue antioxidant defense system.
Husain K, Scott BR, Reddy SK, Somani SM. [Alcohol. 2001 Oct;25(2):89-97.] This study was undertaken to examine the interactive effects of chronic ethanol and nicotine consumption on the antioxidant defense system in different tissues of rat. Chronic ingestion of ethanol resulted in a significant depletion of glutathione (GSH) content in liver, lung, and testes, whereas chronic administration of nicotine significantly depleted GSH content in liver and testes. The combination of ethanol plus nicotine resulted in a significant depletion of GSH content in liver, lung, and testes. Chronic ingestion of ethanol resulted in a significant decrease in glutathione peroxidase (GSH-Px) activity in liver and kidney, whereas a combination of ethanol plus nicotine increased GSH-Px activity in liver and decreased GSH-Px activity in kidney and testes. Ethanol, nicotine, or a combination of ethanol plus nicotine significantly increased lipid peroxidation, respectively, in liver. It is suggested that prolonged exposure to ethanol and nicotine produce similar, and in some cases additive, oxidative tissue injuries in rat.

Treatment of sulfur mustard (HD)-induced lung injury.
Anderson DR, Byers SL, Vesely KR. [J Appl Toxicol 2000 Dec;20(S1):S129-S132] An in vivo sulfur mustard (HD) vapor exposure model followed by bronchoalveolar lavage was developed previously in this laboratory to study biochemical indicators of HD-induced lung injury. This model was used to test two treatment compounds-niacinamide (NIA) and N-acetyl cysteine (NAC)-for their ability to ameliorate HD-induced biochemical changes. These results show that NAC may be useful as a potential treatment compound for HD-induced lung injury.

Role of glutathione redox cycle and catalase in defense against oxidative stress induced by endosulfan in adrenocortical cells of rainbow trout (Oncorhynchus mykiss).
Dorval J, Hontela A. [Toxicol Appl Pharmacol. 2003 Oct 15;192(2):191-200.]
The role of antioxidants in maintaining the functional integrity of adrenocortical cells during in vitro exposure to endosulfan, an organochlorine pesticide, was investigated in rainbow trout (Oncorhynchus mykiss). ...protection against the adrenal toxicity of endosulfan, a pesticide that impairs cell viabilityand cortisol secretion. CAT, GPx, and GSH were identified as important antioxidants in maintaining the function and integrity of rainbow trout adrenocortical cells and ATA, L-BSO, and NAC were identified as effective modulators of CAT and GSH redox cycle. Moreover, this study suggests that the glutathione redox cycle may be more efficient than catalase in protecting adrenocortical cells against endosulfan-induced oxidative stress.

Toxic metals and antioxidants: Part II. The role of antioxidants in arsenic and cadmium toxicity
Patrick L. [Altern Med Rev. 2003 May;8(2):106-28.] Exposure to toxic metals has become an increasingly recognized source of illness worldwide. Both cadmium and arsenic are ubiquitous in the environment, and exposure through food and water as well as occupational sources can contribute to a well-defined spectrum of disease. The mechanisms of arsenic- and cadmium-induced damage include the production of free radicals that alter mitochondrial activity and genetic information. The metabolism and excretion of these heavy metals depend on the presence of antioxidants and thiols that aid arsenic methylation and both arsenic and cadmium metallothionein-binding. S-adenosylmethionine, lipoic acid, glutathione, selenium, zinc, N-acetylcysteine (NAC), methionine, cysteine, alpha-tocopherol, and ascorbic acid have specific roles in the mitigation of heavy metal toxicity. Several antioxidants including NAC, zinc, methionine, and cysteine, when used in conjunction with standard chelating agents, can improve the mobilization and excretion of arsenic and cadmium.

To Learn more about Glutathione, Immunocal, and Immunotec just click here.

The Science of Glutathione

noreply@blogger.com (Dave) — Sat, 12 Jan 2008 17:28:00 +0000

A New Outlook on Life’s Health Challenges
Let’s face it, most of us live a fast-paced lifestyle that is very demanding on our health. The habit of reacting only once the body breaks down is giving way to the realization that prevention can be the best medicine.

Glutathione is emerging as one of the keys to the health puzzle. It was the discovery of glutathione’s importance in optimizing your body’s first line of defense – your immune system – that led to the development of a whey product that raises intracellular glutathione.

Glutathione: The Next Household Word
You may or may not have heard of glutathione, even though over tens of thousands of medical articles have highlighted its importance. Optimizing glutathione levels will shortly join the list of factors known by everyone to have an impact on our health and well-being, along with vitamin supplementation and cholesterol regulation.
Glutathione is a small protein produced naturally in every cell of our body. It is made up of three protein building blocks, called amino acids. These are glutamic acid, cysteine and glycine. The cysteine amino acid contains a sulfur group responsible for the chemical properties of the whole glutathione protein.

Glutathione: An Essential Health AID
There are three major roles of glutathione in the body: Antioxidant, Immune booster, and Detoxifier. Even cells in the healthiest of individuals constantly need to replenish their glutathione supply.

The Master Antioxidant (AID)
Antioxidants participate directly in the destruction of reactive oxygen compounds called free radicals. These by-products of a cell’s normal function can’t be avoided, but exposure to ultraviolet radiation from the sun or other sources promotes their emergence. Free radicals have been linked to muscle fatigue during exercise and aging.

For this reason, the body is equipped with a variety of antioxidants. Vitamins C and E are natural antioxidants but do not occur naturally in the body. These and other antioxidants actually depend on glutathione to function properly, which is why glutathione is called “the Master Antioxidant”.

Food for the Immune System (AID)
Glutathione helps build your immune system’s resistance and improve your chances of staying healthy.

Lymphocytes are cells of your immune system. Glutathione is essential for lymphocytes to increase in number, produce antibodies, and function efficiently.

A Natural Detoxifier (AID)
Our food and water sources are becoming increasingly contaminated with chemicals, as is the air that we breathe. Supplemental detoxifiers such as glutathione help to counter the effects of the toxins we inhale and ingest.

By physically binding to toxic compounds in cells, glutathione helps make them soluble - and harmless. The body can then eliminate these disarmed toxins in the bile and urine.

Raise Glutathione Levels—But How?
The fact is, you can’t ingest glutathione to feed it to your cells. Glutathione must be manufactured within your cells. What you can do is help this natural process by giving your body the glutathione building blocks it needs. The limiting factor in your daily intake of building blocks is the amino acid cysteine.

Cysteine, traveling alone as an amino acid through our digestive system, is poorly absorbed and very little of it will actually make the trip from our mouths to our cells. Luckily, when cysteine molecules bind to each other to travel in pairs, they can survive this process. They do this by forming a bond between sulfur molecules. These bonded cysteine amino acids are then called ‘cystine’. Although this sulfur bond is resistant to the digestive process, it is easily broken if submitted to heat or mechanical stress.

Immunocal’s Unique Manufacturing Process
Before Dr. Bounous and his colleagues devised the technique used to produce Immunocal, the scientific community was unsuccessful at producing a supplement rich in active bonded cysteine.

Immunocal is a highly purified protein powder isolated from whey (milk serum). Immunocal’s secret lies in its proprietary manufacturing process that guarantees:

• The most natural of products isolated in the most natural of conditions.
• A protein source that remains active, which is accomplished by maintaining the fragile, precious bond between cysteine amino acids.
• An even distribution of active protein throughout the product, for the same efficacy inevery serving.

Raise Glutathione Levels - Safely and Naturally
There are other synthetic ways in which glutathione levels may be raised. However, the high level of side effects limits their long-term use. In contrast, Immunocal is just as effective and has no known side effects when used as directed. It contains natural proteins isolated from milk, but a negligible amount of lactose; therefore, even lactose - intolerant individuals can use it safely.

Immunocal: Feeding Bonded Cysteine to Cells
Numerous clinical studies have been performed, using the highest standard of scientific design, to prove Immunocal’s efficacy and reliability. In one such study, Immunocal was proven to raise glutathione levels by 35.5% in lymphocytes.

What’s more, testimonial evidence from thousands of satisfied customers in a dozen countries confirms what science was able to prove: Immunocal works!

*The Effect of Supplementation with a Cysteine Donor on Muscular Performance
Published in the Journal of Applied Physiology, 87: 1381-1385, 1999
by LC Lands, MD, PhD*Ü, VL Grey, PhDÜ‡, AA Smountas, BSc*
*Division of Respiratory Medicine, ÜDepartment of Pediatrics, ‡Department of
Biochemistry, McGill University Health Centre - Montreal Children’s Hospital,
Montreal, Quebec, Canada

This study was conducted in healthy adults for 3 months using the highest standard of scientific design (peer-reviewed, double-blind, randomized, prospective and placebo-controlled study) to ensure validity of the results. Statistical calculations were performed to analyze the results.

Praise and Recognition From the Past and Present
Immunotec Research Ltd., is a research organization first and foremost and as such, is dedicated to marketing products that have received the highest approval from the scientific community. Immunocal is no exception.

Scientists have shown their support for Immunocal in many ways through the years, from its inception to its introduction to the North American market in 1996:

• Immunocal is patent-protected worldwide
• Immunocal is also listed in the U.S. Physicians’ Desk Reference and the Pharmacist’s Red Book
• Immunocal joins a select group of nutritional products qualifying for reimbursement coverage under Medicare/Medicaid in the United States

For a Video Overview on the Immunocal and Immunotec click here.

Presentation about Immunocal on FDA website

noreply@blogger.com (Dave) — Tue, 08 Jan 2008 04:42:00 +0000

The product validation includes a presentation from the FDA website. It references Undenatured Whey Protein Isolate (Immunocal).

Have a look at the presentation.

Get Rid of your Stress

noreply@blogger.com (Dave) — Tue, 08 Jan 2008 02:26:00 +0000

PNT 200 wins bronze at Health Ingredients Europe

Unique peptide is recognized for its calming properties

Those who have discovered PNT 200 know that it is a great way to help relieve the symptoms of stress. And the Health Ingredients (Hi) Europe committee is equally impressed, having recently recognized the effectiveness of its active ingredient with a bronze medal at the 2004 Hi Europe Innovation Awards!

How was this unique peptide discovered? After 12 years of research, in partnership with Université Henri Poincaré-Nancy in France, a peptide was found with relaxing properties within a milk protein hydrolysate. The research stemmed from the observation of the calm state of a baby after drinking milk, prompting researchers to investigate the relationship between milk consumption and any calming effect resulting from it. This led to the use of a well-known digestive enzyme to develop the patented milk casein hydrolysate found in PNT 200.

This discovery was significant, given the amount of stress that people face each and every day. According to the World Health Organization (WHO), nearly 450 million people worldwide are
affected by stress-related disorders. Although high, this number is not surprising when we consider that life is filled with noise, social pressures, pollution and a myriad of other stressors
that infiltrate our minds and bodies.

Despite its negative connotation, stress is a perfectly natural and healthy physiological reaction that is necessary to prepare us to act quickly and efficiently in certain situations; it also allows us to adapt to changing needs and situations. It becomes a negative force when we experience too much stress or are unable to get reprieve from tension - this is when management techniques and products to help lessen the effects of stress come into play.

PNT 200 is perfectly positioned for today’s fast-paced life and the recognition of its active ingredient is an important milestone for the product. The Health Ingredients award further substantiates its value and the science that it is based on. PNT 200 is the natural alternative for those who are looking to better manage the stresses of everyday life.

For more information on PNT 200 click here.

Summary of Medical Publications on Immunocal/HMS 90

noreply@blogger.com (Dave) — Tue, 08 Jan 2008 00:33:00 +0000

As I mentioned in my last blog, and as unscrupulous as it may sound, there are some companies out there that sell products that proclaim to raise intracellular Glutathione without having done their "homework".

Due to the extensive research done by Dr. Gustavo Bounous - co-founder of Immunotec, invariably they will reveal that their product is based upon OUR research. Our research is the reason why we have 10 Method of Use patents (our product does what we say it does).

Always do your Due Diligence and ask to see their research using their product.

Here's some of ours...........

Bounous G., Molson J.

Competition For Glutathione Precursors Between The Immune System And The Skeletal Muscle: Pathogenesis Of Chronic Fatigue Syndrome.

Med Hypotheses. 1999 Oct;53(4) :347-349.

Kennedy R.S., Konok G.P., Bounous G., Baruchel S., Lee T.D.

The Use Of A Whey Protein Concentrate In The Treatment Of Patients With Metastatic Carcinoma : A Phase I-II Clinical Study.

Anticancer Res. 1995 Nov-Dec;15(6B) :2643-2650.

Bounous G., Baruchel S., Falutz J., Gold P.

Whey Proteins As A Food Supplement In HIV-Seropositive Individuals.

Clin Invest Med. 1993 Jun;16(3) :204-209.

Bounous G., Gold P.

The Biological Activity Of Undenatured Dietary Whey Proteins : Role Of Glutathione.

Clin Invest Mod. 1991 Aug;14(4) :296-309.

Bounous G., Batist G., Gold P.

Whey Proteins In Cancer Prevention.

Cancer Lett. 1991 May 1;57(2) :91-94. Review Letter.

Papenburg R., Bounous G., Fleiszer D., Gold P.

Dietary Milk Proteins Inhibit The Development Of Dimethylhydrazine-Induced Malignancy.

Tumour Biol. 1990;11(3) :129-136.

Bounous G., Gervais F., Amer V., Batist G., Gold P.

The Influence Of Dietary Whey Protein On Tissue Glutathione And The Diseases Of Aging.

Clin Invest Med. 1989 Dec;12(6) :343-349.

Bounous G., Batist G., Gold P.

Immunoenhancing Property Of Dietary Whey Protein In Mice: Role Of Glutathione.

Clin Invest Med. 1989 Jun;12(3) :154-161.

Bounous G., Kongshavn P.A., Gold P.

The Immunoenhancing Property Of Dietary Whey Protein Concentrate.

Clin Invest Med. 1988 Aug;11(4) :271-278.

Bounous G., Papenburg R., Kongshavn P.A., Gold P., Fleiszer D.

Dietary Whey Protein Inhibits The Development Of Dimethylhydrazine Induced Malignancy.

Clin Invest Med. 1988 Jun;11(3) :213-217.

Bounous G., Shenouda N., Kongshavn P.A., Osmond D.G.

Mechanism Of Altered B-Cell Response Induced By Changes In Dietary Protein Type In Mice.

J Nutr. 1985 Nov;115(11) :1409-1417.

Bounous G., Kongshav.n. PA.

Differential Effect Of Dietary Protein Type On The B-Cell And T-Cell Immune Responses In Mice.

J Nutr. 1985 Nov;115(11) :1403-1408.

Bounous G., Letourneau L., Kongshavn P.A.

Influence Of Dietary Protein Type On The Immune System Of Mice.

J Nutr. 1983 Jul;113(7) :1415-1421.

Costantino A.M., Balzola F., Bounous G.

Changes in biliary secretory immunoglobulins A in mice fed whey proteins.

Minerva Dietol Gastroenterol 1989 35(4): 241-5

Baruchel S., Bounous G., Gold P.

Place For An Antioxidant Therapy In Human Immunodeficiency Virus (HIV) Infection.

Oxidative Stress, Cell Activation and Viral Infection – C. Pasquier et al. (eds) 1994; 311-321.

Bounous G., Kongshavn P.A.

Influence Of Dietary Proteins On The Immune System Of Mice.

J Nutr. 1982 Sep; 112(9) :1747-55.

Bounous G., Stevenson M.M., Kongshavn P.A.

Influence Of Dietary Lactalbumin Hydrolysate On The Immune System Of Mice And Resistance To Salmonellosis.

J Infect Dis. 1981 Sep; 144(3) :281. No abstract available.

Lands L.C., Grey V.L., Smountas A.A.

Effect Of Supplementation With A Cysteine Donor On Muscular Performance.

J Appl Physiol. 1999 Oct;87(4) :1381-1385.

Lothian B., Grey V., Kimoff R.J., Lands L.C.

Treatment Of Obstructive Airway Disease With A Cysteine Donor Protein Supplement: A Case Report. Chest. 2000 Mar;117(3) :914-6.

Watanabe A., Higuchi K., Okada K., Shimizu Y., Kondo Y., Kohri H.

Treatment Of Chronic Hepatitis Using Whey Protein (Non-Heated)

16^th International Congress of Nutrition (Montreal, Canada 1997).

Bounous G.

Whey Protein Concentrate (WPC) And Glutathione Modulation In Cancer Treatment.

Anticancer Research 20 :4785-4792 (2000)

Tsai W.Y., Chang W.H., Chen C.H., Lu F.J.

Enhancing Effect Of Patented Whey Protein Isolate (ImmunocalÔ) On The Cytotoxicity Of Anti-Cancer Drug.

Nutrition and Cancer, Vol 38, Issue #2.

Baruchel S., Viau G., Olivier R., Bounous G., Wainberg M.A.

Nutriceutical Modulation Of Glutathione With A Humanized Native Milk Serum Protein Isolate, ImmunocalÔ : Application In AIDS And Cancer.

Marcel Dekker Inc. – New York – Basel – Hong Kong

BOUNOUS G., MOLSON J.

The Antioxidant System

Anticancer Research 23: 1411-1416 (2003)

Bartfay WJ, Davis MT, Medves JM, Lugowski S

Milk Whey Protein decreases Oxygen Free Radical Production in a Murine Model of Chronic Iron-Overload Cardiomyopathy

Can J. Cardiol Vol 19 No 10, Sept. 03: 1163-1168 (2003)

Bounous G., Beer D.

Molecular Pathogenesis and Prevention of Prostate Cancer

Anticancer Research 24: 553-554 (2004)

GREY V., MOHAMMED S.R., SMOUNTAS A.A., BAHLOOL R., LANDS L.C.

Improved Glutathione Status in Young Adult Patients with Cystic Fibrosis Supplemented with Whey Protein

Journal of Cystic Fibrosis, Vol. 2, Issue 4, (2003)

BAUMANN J.M., RUNDELL K.W., EVANS T.M., LEVINE A.M.

Effects of Cysteine Donor Supplementation on Exercise-Induced Bronchoconstriction

Med. Sci. sports Exerc., Vol. 37, No. 9, pp1468-1473, (2005).

dröge w.

Oxidative stress and ageing: is ageing a cysteine deficiency syndrome?

Phil. Trans. R. Soc. B., Vol. 360, 2355-2372, (2005)

Patents Make a Difference

noreply@blogger.com (Dave) — Sat, 05 Jan 2008 19:25:00 +0000

Some products on the market today promote themselves using the research of other companies. It is easy for a company to get a Composition Patent. Basically, submit your "recipe" for your product and you can claim that your product is patented. But what does that really mean to me and you?

Method of Use patents on the other hand, are Very Different. In order to get this type of patent you need to complete double blind studies (using your product), peer reviewed papers, needs to be renewed annually and on an on.

Immunocal has 10 Method of Use patents.

To see the U.S. and Canadian patents, click on the links below.

United States: 5,888,552, 5,451,412, 5,230,902, 5,456,924, 5,290,571, 5,846,939

Canada: 2,142,277 2,090,186 1,333,471 1,338,682

Immunocal and Autism

noreply@blogger.com (Dave) — Sat, 05 Jan 2008 15:33:00 +0000

There is a ton of anecdotal evidence that raising Glutathione helps with Autism over the years. In fact there is a study at University of Texas Southwestern Medical Center in Dallas. It has been so successful that it is now entering Phase II studies. Here is the original press release:

Immunotec Research Ltd., Leading Canadian Nutraceutical
Company, Initiates U.S. Autism Research Project

MONTREAL, November 22, 2006--- Scientists at the University of Texas Southwestern Medical Center in Dallas have started a study in which a specially formulated whey protein isolate(Immunocal) will be used to raise glutathione levels in an attempt to lessen symptoms of autism.

Autism is a neurological developmental disorder that affects children’s ability to socialize normally, impairs language skills, restricts their interests and curiosity and causes other behavioral abnormalities. Most cases are diagnosed before three years of age, and there has been an alarming increase in the number of cases diagnosed over the past two decades. Currently, 1 in every 175 American children is being identified as having autism, and these numbers are on the rise each year.

To date, medical treatment of this disorder has been minimally effective. Although the causes of autism have not been clearly identified, research has suggested that chronic biochemical imbalance plays a role. Studies have shown that levels of the major intracellular antioxidant “Glutathione” is typically about 50% lower in children with autism. Glutathione, which is
produced by every cell in the body, is responsible for a number of functions including removing or neutralizing dangerous substances that we are exposed to on a daily basis, including toxic metals. Toxins, pollution, disease, stress, and poor diet can all contribute to loss of glutathione. When glutathione levels reach a critically low degree, we are much more vulnerable to toxins and immune dysfunction.

Principal investigator for this study is Dr. Janet Kern, an adjunct assistant professor of psychiatry at UT Southwestern, which is internationally recognized for its clinical and research programs. “Some children with autism are poor detoxifiers relative to normally developing children, and in particular, have trouble excreting toxic metals,” said Dr. Kern. “Toxic metals that are not eliminated may build up in the brain. Plasma glutathione has been found to be lower in children with autism, particularly, in children with autism who have regressed. We want to clearly establish that raising glutathione levels in these children will improve their ability to detoxify these substances and in that way improve some of their symptoms.”

Dr. Jill James, Professor of Pediatrics at University of Arkansas for Medical Sciences, will be a coinvestigator. Dr. James is noted for her landmark studies in autism and toxicology and is among the first scientists to point out the links with low glutathione levels. “We know that Immunocal has been used to raise glutathione in other studies very effectively in areas such as cancer and lung disease. We want to take advantage of this same technology”, stated James.

For more information go to www.gsh-booster.com

Just Learning to Blog

noreply@blogger.com (Dave) — Sat, 05 Jan 2008 14:51:00 +0000

As a beginner blogger is helps to look at other peoples work for inspiration.

Colin is the author of many blogs; Golden eBooks for Newbies, Search Engine Optimization and Traffic Tips, Free PC Security. MySpace Blog, Safety Tips for Newbies, Golden eBooks Blog, 6 Ways to Make Money at Home, Top Affiliate Tactics, Life. He has presented the Be The Blog award and Best Blogging Buddies award to the following:

0-Cotojo 1-Lisa , 2-Kim, 3-Deborah, 4-Pearl, 5-Sandy, 6-Jesse, 7-Chris, 8- Colin 9-Santa, 10-Blog Elf, 11-Jackie, 12-Marzie, 13-Adrian, 14-Jos, 15-NAFA SG, 16-Paula, 17-Sue, 18-Kathy 19-Maartje, 20-Morgan, 21-Greg, 22-MaryAnn, 23-Eric, 24-Hawk, 25-Carol, 26-Diane, 27-Ev Nucci, 28-Surjit, 29-Kuanyin, 30-Christy Z, 31-Sandee, 32-Robin, 33-Hanna, 34-Maunie, 35-Kim, 36-Bobby, 37-Billy, 38-David, 39-Jennifer, 40-Aryst, 41-Winston, 42-Christy, 43-LilyRuth, 44-Jess, 45-Rudy, 46-Lynda, 47-Lili, 48-Sandy G, 49-Ange, 50-BlackWyrm, 51-Vincent, 52-Colin & Anne, 53-Blandly Urbane, 54-Marco, 55-Mihaela Lica, 56-John C, 57-Aziz-sm, 58-Ugyen, 59-Lansy, 60-Alex Badalic, 61-Victors, 62-Nostalgia Manila, 63-Franco Yong, 64-Herby, 65-Rubie, 66-Santaram & BVK, 67-Jean-david, 68-Namgay, 69-Catherine, 70-Yunita P, 71-Debbie Dolphin, 72-Lorimer Black, 73-Dream Catcher, 74-Fred Plimley, 75-Anja Merret,76-Maria Lourdes, 77-Jon B, 78-Aayush, 79-Denise, 80-Dharmendra P, 81-Brent D, 82-Jerry & Daryl McCoy, 83-Brian B, 84-Calvin Innes, 85-Pieter Marburn, 86-Jessica Field, 87-Taflas, 88-Alex Sysoef, 89-Norie, 90-Justin Stanley, 91-Ashish, 92-David Ledoux, 93-Thanate Tan, 94-Kevin, 95-Etienne, 96-Gerbera, 97-Christina, 98-Abhishek d, 99-Uprai, 100-Texas_Jam, 101-Azmiel, 102-Daniel, 103-Kristin B, 104-Luwis, 105-Adavait, 106-Now Sourcing, 107-Buen Amigo, 108-Kiran Pande, 109-Peterson Wong, 110-Lynn, 111-Chessnoid, 112-Luis Hipolito, 113-Joliveira, 114-Jennifer & Pete, 115-Team Dog, 116-Megan, 117-Mark, 118-Raivyn, 119-Mel, 120-Andrea, 121-Jen / domestika, 122-Mimi, 123-Bobo, 124-Lynda Lehmann, 125-Dread Bob, 126-Julie, 127-RennyBA, 128-Bobbarama, 129-Becky, 130-Magdalena, 131-Michelle, 132-Stacie, 133-Climate of Our Future Team, 134-CashMarble, 135-OilOffShoreMarine, 136-Jos Additional BlogLove, 137-Piper, 138-Barbara, 139-Ann Clemmons, 140-Deb, 141-madang.com, 142-RamblingMoo.com, 143-blogginginmypyjamas, 144-StylewithPassion, 145-Chinneeq, 146-Dora-zooropazoo, 147-Babyshern, 148-HiPnCooLMoMMa 149-Rachel’s Soulful Thoughts 150-When Silence Speaks, 151-Dancing in Midlife Tune, 152-Underneath it All, 153- I am Dzoi, 154-Hobbies and Such, 155-moms…..check nyo, 156-Choc Mint Girl, 157-Amel’s Realm, 158- My Thoughts, 159-Rusin Roundup, 160-Juliana’s Site, 161-Max, 162-Rooms of My Heart, 163-A Great Pleasure, 164-LadyJava’s Lounge, 165-Jesie, 166-Steven, 167-Trinity, 168-Leena, 169-Nick, 170-Nessa, 171-Debbie Dolphin, 172- Anna t, 173-krrey_boo, 174-Logic, 175-Steve Ho, 176-Virtual Entrepreneur, 177-WalksFarWoman, 178-Anna, Beth & Cory’s Mom, 179-Toon, 180-Belinda 181-EPSpeaks, 182-Teacher Julie 183-jafajfer, 184-pmonchet, 185-Aslan, 186-arouetvoltaire , 187-Tanny, 188-Il vaso di Pandora, 189-Non Lineare, 190-Omniamundamundis, 191-LineaNeuronica, 192-Semplicemente Lisa 193-la penna che graffia 194-Angelbaby, 195-Divya, 196-Cyn, 197-Donna, 198-Liudmila, 199-djeblog, 200-Gracie Belle, 201-Reverend Ray, 202-Walter Winstuff, 203-Denny, 204-Terry (mee mOe), 205-awannabe, 206-Z.S., 207-Il Gnagnera, 208-Kevin Grieves, 209-DatCurious, 210-DatMoney, 211-Sanni, 212-Rolando’s Quiet Space, 213-SatoNa ,214-Levian , 215-21Knots, 216-PuTLie,217-Riciard’s, 218-Darlene, 219-Rantings of a Woman,220-La Place de Cherie , 221-Enjoying The Ride, 222-A Window To Our World,223-Juliana, 224-Retchel’s Pure Life, 225-We Are Family,226-Yesterday, Today and Tomorrow, 227-Echoes of Life, 228-My 3 Boys and I,229-Mammagatta, 230-Juliana’s Lair, 231-Bless Sanctuary,232-Confessions of An Army Wife , 233-Jean’s my So-called Life, 234-So cute tiny pixels,235-Denz Techtronics Blog, 236-Wanna Be On Top!, 237-Carpe Diem,238-My so-called Life, 239-TEEBOB, 240-Kikay,241-Alaverde33, 242-CC’s Lifestyles and Reviews, 243-Pinay’s Lifestyles,244-Yesterday, Today and Tomorrow, 245-The Creativity Of Me, 246-OzLife247-Scattered Thoughts of Mine, 248-Another Journal of Mine, 249-My Drama,250-By The Way, 251-Paul, Toni and Lance - Bridging the Distance, 252-Live Love Pink,253-In The Lance’s Mind, 254-My Life, 255-Rants and Ramblings,256-WorldBlog, 257-Our Journey to Life, 258-Simply the best,259-Paul and Toni, 260-Alpha’s Blog, 261-because life is fun,262-The Simple Life of a Baghag, 264-Sweet Lullaby, 265-AnitoKid, 266- Lisa WAHM, 267-Ben Spark268-Kesa, 269-Mauro, 270-Sindi271-Alianorah, 272-Jennie, 273-CTN,274-Jeremy, 275-Polliwog’s Pond, 276-Yvette,277-Ali (DorisDay), 278-Rodney, 279-Alice, 280- WBAustin, 281-Max, 282-Rodney283-Karen, 284-Michelle, 285-Stacy286-SvenMarin, 287-CoolingStar9, 288-Billy Jack,289-bbrian, 290-Cris Zimermann, 291-Franx,292-Ramil, 293-JaniceNW, 294-Cathrina Jones 295-Bels, 296-Raman, 297-Jeques,298-NPSG, 299-Anndi, 300-Georganna,301-Jeane Michelle Culp, 302-Sam Chan, 303-Kumowai,304-Michiko, 305-Buchiko, 306-Doodski, 307-Jeevy, 308-Sameera, 309-Annita, 310-Sweet Girl, 311-Jeya Anand

Promote Glutathione

noreply@blogger.com (Dave) — Sat, 05 Jan 2008 04:53:00 +0000

One of the newest and most popular sites is Squido.

Here is my new site

http://www.squidoo.com/Boostyourglutathione

The top 4 causes of Poor Health, Chronic Disease and Aging.

noreply@blogger.com (Dave) — Sat, 05 Jan 2008 03:25:00 +0000

1. Dehydration.

The importance of Water cannot be understated. The average person needs 2.5 liters of liquid intake per day to remain fully hydrated. A good guide for your daily water intake is to drink half your body weight in ounces of water each day. Add to that if you are doing strong physical activity.

To remain in balance, you simply must intake 2.5 liters of fluid a day. When your body is dehydrated, the first signs are headaches and fatigue. To make matters worse, your body will draw the water from other sources such as the colon, which provides some extra water, but leaves you constipated. Does any of this ring true for you? I also used to think the water in coffee, soda, beer, etc, would count as part of my water intake. Packaged drinks are made using distilled water. The more distilled water a person drinks, the more acidic the body becomes. The drinks themselves are diuretics and will only make you more dehydrated by flushing water from your system. Drinking more and better quality water is the key. Carbonated and distilled water are both acidic and are the wrong kinds of water.

2. Free Radicals.

We've all heard about free radicals and the damage they can do. Unstable atoms that bounce around inside our bodies, they destroy healthy cells as they search for 2 more electrons. Free radicals have an oxidizing effect on the body. We know they account for 70% of diseases such as cancer and diabetes and help to accelerate the aging process.

Free radicals come from everything we ingest - foods, drinks, smoking, alcohol and pollution. In fact, 2% of every breath you take ends up as free radicals, which blows out to 20% during heavy exercise. At times of rest, our bodies can handle the load to some extent, but in times of stress and fatigue, the body just can't keep up. Getting rid of these oxidizing free radicals is key to being healthy. Boosting your Glultathione with Immunocal is the best way.

3. Acidosis

You know what the top selling medication is in the US? Antacid. We are an acidic nation and acidosis is simply the name for having an acidic body caused by diet and lifestyle.

Probably the most acidic food is any cooked meat, followed by simple sugars, processed dairy, coffee and alcohol. But they are also the staples of most diets. The alkaline foods such as fruits, vegetables and nuts and high pH water are not the staples of most diets. Over acid makse us sick, tired and overweight, maintaining a healthy pH gives us health and wellness.

What you eat and what you drink affects the alkaline/acid balance of the fluids in the body. We all need to focus more on alkalizing foods to counteract some of the acid.

4. Intestinal Disorders.

We all know that most of what we ingest is absorbed via the intestinal tract. The vitamins, minerals, and nutrients we need in order to survive are extracted and absorbed from what we consume. The intestines also have to handle the toxins, pesticides, heavy metals, chemicals, preservatives, hormones and carcinogens we find in modern day, processed foods.

Not surprisingly, the intestines require water to flush these toxins away. When working properly and hydrated, this process of food waste flows smoothly, but when the body is dehydrated, the intestines become cess pools of fetid matter. This matter sticks to the intestinal walls, resulting in a double whammy for our health. It becomes more difficult for the body to absorb nutrients and for the toxins to be flushed out. This in turn affects the blood, and when the blood is toxic, so too are the organs it supplies. We know the average person has between 5 and 22 pounds of caked, rancid, decaying, fecal matter stuck inside their intestines. We know about the compromised absorption of nutrients, but this build up also creates free radicals. We know that almost all diseases originate in the colon, or the toxic cesspool of fetid, fecal matter as the case may be.

Diseases Related to Oxidative Stress

noreply@blogger.com (Dave) — Fri, 04 Jan 2008 02:57:00 +0000

Every moment we are alive, cells within our bodies are dying and being created. Oxidation within cells occurs as they "burn fuel and oxygen". Its our ability to deal with the oxidative stress that determines our overall health.

If oxidative stress continually happens at a greater rate than we are capable of dealing with, it results in sickness and eventually disease. You may be surprised by the multitude of disease that are related to Oxidative Stress.

The best strategy is to ensure adequate levels of antioxidants in your diet.

Neurodegenerative Diseases

Parkinson disease, Alzheimer disease, Multiple Sclerosis, Schizophrenia, Dementia, Huntington’s disease

Aging Diseases

Arthritis, Diabetes, Osteoarthritis, Cataract, Macular Degeneration, Prostate problems

Cancer

Prostate cancer, Breast cancer, Lung cancer, Colorectal cancer, Bladder cancer, Uterine cancer, Ovarian cancer, Lymphoma, Skin cancer, Stomach cancer, Liver cancer & other Wasting Disease

Liver Diseases

Toxic Hepatitis, Viral Hepatitis (A, B, C), Chronic Hepatitis, Cirrhosis

Lung Diseases

Asthma, Emphysema, Pneumonia, Bronchitis (chronic and acute), Cystic fibroses, Pulmonary fibroses, Chronic obstructive pulmonary disease (COPD), Adult respiratory distress syndrome (ARDS)

Cardiovascular Diseases

Arteriosclerosis & its consequences, Heart failure, Heart Attack, Kidney failure, High blood pressure, Stroke, Impaired circulation, Heart disease, Cholesterol and plaque formation, Reperfusion injury

Digestive Diseases

Inflammatory bowel disease, Ulcerative colitis, Crohn’s disease, Gastritis, Stomach cancer, Pancreatitis, Peptic ulcer

Kidney Failure & Dialysis

Kidney failure, Renal toxicity, Oxidative stress from dialysis

Infectious Diseases and Immunology

Viral infection HIV and AIDS, Toxic Hepatitis & cirrhosis, Viral hepatitis (type A, B, & C), Herpes, Common Cold, Bacterial infection, Chronic fatigue syndrome, Certain autoimmune dysfunction

Skin Disorders

Psoriases, Eczema, SLE (lupus), Vasculitis, Polymyositis, Mycosis fungoides, Scleroderma Pemhigoid, Atopic dermatitis, Contact dermatitis, Sebborrheic dermatitis, Dermatitis herpetiformis, Acne conglobata, Acne vularis, UV radiation skin damage

Eye, Ear, Nose, Throat & Teeth

Cataract, Glaucoma, Macular degeneration, Hearing loss, Ear infection, Sinusitis, Periodontal (gum) disease, Nose, mouth & throat (upper respiratory tract) disease

Pregnancy, Lactation & Childbirth

Pre-eclampsia, Eclampsia, Hypertension, Diabetes, GSH eliminates toxins and provides antioxidant defense system to the fetus during pregnancy. Mother’s milk (ideal precursor of GSH) has a very important role for the health and development of newborns, especially the long-term effects on the immune system.

Exercise & Athletic Performance

Over-Training Syndrome & the related oxidative stress

Male Problems

Prostate enlargement, Prostate cancer, Balding and hair loss, Male infertility.

For more information go to Glutathione The Master Antioxidant.

Immnocal Platinum - "Plain and Simple"

noreply@blogger.com (Dave) — Wed, 02 Jan 2008 01:53:00 +0000

In real simple terms, the unimprovable product (Immunocal) just got better.

It all starts with a package of Bonded Cysteine (Immunocal/HMS 90) which assists the body in maintaining optimal concentrations of glutathione (GSH) by supplying the precursors required for intracellular glutathione synthesis. Immunocal is clinically proven to raise glutathione values (Lands et al, 1999). Immunocal Platinum also contains additional lactoferrin to enhance and modulate immune-function.

CMP (Cytokine Modulation Proteins) A Cytokine is a protein released by the immune system. Cytokines can be good or bad. That is why they need to be modulated, controlled and redirected. Cytokines are good when they help your immune system attack invaders such as bacteria and viruses. Cytokines are good when you have an injury, because they signal special proteins to heal cell damage. Cytokines can be bad when the body uses them to attack the tissues of our body. This is called autoimmune disease. ‘Short term’ inflammation is good because the body uses cytokines to destroy germs. Chronic (long-term) inflammation is bad for the body because it causes damage, like rheumatoid arthritis. When you have an infection, cytokines signal proteins to heal cell damage. As we age, the process of balancing good inflammation and eliminating bad inflammation doesn’t always function as it should. Consequently, a common factor in chronic disease is the presence of low grade chronic inflammation, which can manifest itself in the form of cancer, stroke or heart disease, etc. Cytokine Modulation helps to balance this process and reduce the inflammation while promoting healthy cell growth and proper immune function. This is one of three main functions of Immunocal Platinum.

RMF Redox Modulating Formula will:

Improve mood, energy and mental acuity
Balance calcium and prevent calcium loss
Slow down cell damage, a cause of aging
Neutralize acid production from high protein intake. We now know that it is better to be alkaline.
Modulate insulin
Promote healthy weight management

Immunocal Platinum is EASY to take. Immunocal Platinum works best when taken first thing in the morning on an empty stomach.

Enhances the immune system
Repairs damaged cells & promotes healthy cell growth
Inhibits abnormal cell growth
Prevents acid from building in the body
Slows calcium loss
Improves insulin metabolism
Improves mood, energy, well-being, alertness, concentration and clarity