Latest news from the International Union of Basic and Clinical Pharmacology database of G protein-coupled receptors (GPCRs), voltage-gated and ligand-gated ion channels. http://www.iuphar-db.org/ http://www.iuphar-db.org/http://www.iuphar-db.org/images/iuphar_side_logo.gifIUPHAR-DBhttp://feedburner.google.comSubscribe with My Yahoo!Subscribe with NewsGatorSubscribe with My AOLSubscribe with BloglinesSubscribe with NetvibesSubscribe with GoogleSubscribe with The Free DictionarySubscribe with Live.comAdd to Any Feed ReaderLatest news from the International Union of Basic and Clinical Pharmacology database of G protein-coupled receptors (GPCRs), voltage-gated and ligand-gated ion channels. The initial LGIC data release includes detailed annotation and introductions for 3 families. The new LGIC families are: the 5-HT3 receptors, the Glycine receptors and the Zinc-activated channel. Annotation of further LGIC families is underway.<img src="http://feeds.feedburner.com/~r/IUPHAR-DB/~4/Fxqqrgoi698" height="1" width="1"/> http://feedproxy.google.com/~r/IUPHAR-DB/~3/Fxqqrgoi698/ReceptorFamiliesForward LGICs June 2009 http://www.iuphar-db.org/IC/ReceptorFamiliesForward The latest data release includes detailed annotation for 7 VGIC families, which, together with the LGICs, represents a signicant addition to the IUPHAR ion channels database. The new VGIC families are: the Calcium-Activated Potassium Channels, the CatSper and Two-Pore Channels, the Cyclic Nucleotide-Regulated Channels, the Inwardly Rectifying Potassium Channels, the Voltage-Gated Calcium Channels, the Voltage-Gated Potassium Channels and the Voltage-Gated Sodium Channels.<img src="http://feeds.feedburner.com/~r/IUPHAR-DB/~4/Fxqqrgoi698" height="1" width="1"/> http://feedproxy.google.com/~r/IUPHAR-DB/~3/Fxqqrgoi698/ReceptorFamiliesForward VGICs June 2009 http://www.iuphar-db.org/IC/ReceptorFamiliesForward In the latest release, 3 GPCR families have been updated: 1) detailed annotation and an introduction are now available for the Melanin-concentrating hormone receptor family; 2) the P2Y receptor family data and introduction have been updated; and 3) an introduction has been added for the Estrogen G protein-coupled receptor.<img src="http://feeds.feedburner.com/~r/IUPHAR-DB/~4/TEmw4kbfnpQ" height="1" width="1"/> http://feedproxy.google.com/~r/IUPHAR-DB/~3/TEmw4kbfnpQ/ReceptorFamiliesForward GPCRs June 2009 http://www.iuphar-db.org/GPCR/ReceptorFamiliesForward Three publications have recently suggested lysophosphatidylinositol as an endogenous ligand for the orphan receptor GPR55.<img src="http://feeds.feedburner.com/~r/IUPHAR-DB/~4/lsv-sga5KuE" height="1" width="1"/> http://feedproxy.google.com/~r/IUPHAR-DB/~3/lsv-sga5KuE/latestPairings.jsp http://www.iuphar-db.org/latestPairings.jsp#GPR55-LPI http://www.iuphar-db.org/latestPairings.jsp#GPR55-LPI Two publications have recently suggested lactate as an endogenous ligand for the orphan receptor GPR81.<img src="http://feeds.feedburner.com/~r/IUPHAR-DB/~4/tSPqzjXuLWM" height="1" width="1"/> http://feedproxy.google.com/~r/IUPHAR-DB/~3/tSPqzjXuLWM/latestPairings.jsp http://www.iuphar-db.org/latestPairings.jsp#GPR81-lactate http://www.iuphar-db.org/latestPairings.jsp#GPR81-lactate The dopamine receptor family introduction has been updated.<img src="http://feeds.feedburner.com/~r/IUPHAR-DB/~4/xAgO39lSLMo" height="1" width="1"/> http://feedproxy.google.com/~r/IUPHAR-DB/~3/xAgO39lSLMo/IntroductionDisplayForward GPCR intro=1282 http://www.iuphar-db.org/GPCR/IntroductionDisplayForward?chapterID=1282 The adrenoceptor family has been updated.<img src="http://feeds.feedburner.com/~r/IUPHAR-DB/~4/Xcna6ZY5E0U" height="1" width="1"/> http://feedproxy.google.com/~r/IUPHAR-DB/~3/Xcna6ZY5E0U/ChapterMenuForward GPCR chapter=1274 http://www.iuphar-db.org/GPCR/ChapterMenuForward?chapterID=1274 The muscarinic acetylcholine receptor family introduction has been updated.<img src="http://feeds.feedburner.com/~r/IUPHAR-DB/~4/S540DVxFVyQ" height="1" width="1"/> http://feedproxy.google.com/~r/IUPHAR-DB/~3/S540DVxFVyQ/IntroductionDisplayForward GPCR intro=1271 http://www.iuphar-db.org/GPCR/IntroductionDisplayForward?chapterID=1271 The nomenclature of ligand-gated ion channels and their subunits has recently been re-examined by NC-IUPHAR. Their revised recommendations for nomenclature are summarised.<img src="http://feeds.feedburner.com/~r/IUPHAR-DB/~4/EW7N9M7kQyY" height="1" width="1"/> http://feedproxy.google.com/~r/IUPHAR-DB/~3/EW7N9M7kQyY/hotTopics.jsp http://www.iuphar-db.org/hotTopics.jsp#LGIC-nomenclature http://www.iuphar-db.org/hotTopics.jsp#LGIC-nomenclature A new Nomenclature Guidelines information page is available at http://www.iuphar-db.org/nomenclature.html, providing links to key NC-IUPHAR receptor nomenclature documents<img src="http://feeds.feedburner.com/~r/IUPHAR-DB/~4/JBnLyxNpovM" height="1" width="1"/> http://feedproxy.google.com/~r/IUPHAR-DB/~3/JBnLyxNpovM/nomenclature.html http://www.iuphar-db.org/nomenclature.html http://www.iuphar-db.org/nomenclature.html The database search facility has been improved - with faster performance and more comprehensive searches. In addition to a quick search tool on the left hand side of every page, a new 'Advanced Search' page offering further search options is now available.<img src="http://feeds.feedburner.com/~r/IUPHAR-DB/~4/nM7AJO_h9Vw" height="1" width="1"/> http://feedproxy.google.com/~r/IUPHAR-DB/~3/nM7AJO_h9Vw/searchPage.jsp http://www.iuphar-db.org/searchPage.jsp http://www.iuphar-db.org/searchPage.jsp The 2.6 Angstrom crystal structure of a human A2A adenosine receptor bound to the antagonist ZM241385 has been reported.<img src="http://feeds.feedburner.com/~r/IUPHAR-DB/~4/fiIMB8FQFxM" height="1" width="1"/> http://feedproxy.google.com/~r/IUPHAR-DB/~3/fiIMB8FQFxM/hotTopics.jsp http://www.iuphar-db.org/hotTopics.jsp#A2A-adenosineReceptor http://www.iuphar-db.org/hotTopics.jsp#A2A-adenosineReceptor Trace Amine receptor has been added to the GPCR database.<img src="http://feeds.feedburner.com/~r/IUPHAR-DB/~4/ce6FtxTwP2g" height="1" width="1"/> http://feedproxy.google.com/~r/IUPHAR-DB/~3/ce6FtxTwP2g/ChapterMenuForward GPCR chapter=1355 http://www.iuphar-db.org/GPCR/ChapterMenuForward?chapterID=1355 Gonadotrophin-releasing hormone receptors have been added to the GPCR database.<img src="http://feeds.feedburner.com/~r/IUPHAR-DB/~4/PlMz2d8pwUU" height="1" width="1"/> http://feedproxy.google.com/~r/IUPHAR-DB/~3/PlMz2d8pwUU/ChapterMenuForward GPCR chapter=1357 http://www.iuphar-db.org/GPCR/ChapterMenuForward?chapterID=1357 The orphan receptor CMKOR1 (commonly referred to in the literature as CXCR7) binds the CXC chemokines CXCL11 and CXCL12/SDF-1 with high affinity.<img src="http://feeds.feedburner.com/~r/IUPHAR-DB/~4/VYRgZtdDPQE" height="1" width="1"/> http://feedproxy.google.com/~r/IUPHAR-DB/~3/VYRgZtdDPQE/latestPairings.jsp http://www.iuphar-db.org/latestPairings.jsp#CMKOR1-CXCL11+CXCL12 http://www.iuphar-db.org/latestPairings.jsp#CMKOR1-CXCL11+CXCL12