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Targets
- G protein-coupled receptors
- Ion channels
- Nuclear hormone receptors
- Kinases
- Catalytic receptors
- Transporters
- Enzymes
- Other protein targets
Ligands
- Approved drugs
- Synthetic organics
- Metabolites
- Natural products
- Endogenous peptides
- Other peptides
- Inorganics
- Antibodies
- Labelled ligands
Resources
Database Reports
View all our past database reports on our downloads page. Reports are also accessible, along with database update presentations, on our Zenodo archive. latest report DOI: 10.5281/zenodo.11046804.
Advanced Search: Targets | Target Pharmacology | Ligands | Chemical Structure
Current Release Version 2026.1 (12th March 2026). Read our release notes blog.
Ligand Activity Charts
Use our interactive ligand activity charts to compare pharmacology across targets and species.
NAR Database Issue
The Guide to Pharmacology in 2026
Our latest update in NAR Database Issue has been published and is available online. Includes developments in antibacterial, natural product and nucleic acid-based ligand curation and an improved presentation of approved drugs.
Malaria Pharmacology
Optimised access for the malaria research community
Latest News and Hot Topics in Pharmacology
The Concise Guide to PHARMACOLOGY 2025/26
Recent Publications
Insight into structural properties of viral G protein-coupled receptors and their role in the viral infection: IUPHAR Review 41
Tsutsumi N, Kildedal DF, Hansen OK, Kong Q, Schols D, Van Loy T, Rosenkilde MM. (2024) Br J Pharmacol. EPub ahead of print. 10.1111/bph.17379. 
Targeting RNA with small molecules, from RNA structures to precision medicines: IUPHAR review: 40
Tong Y, Childs-Disney JL, Disney MD. (2024) Br J Pharmacol. EPub ahead of print. doi: 10.1111/bph.17308.
Advancing the field of viroporins-Structure, function and pharmacology: IUPHAR Review 39
Devantier K, Kjær VMS, Griffin S, Kragelund BB, Rosenkilde MM. (2024) Br J Pharmacol. EPub ahead of print. 10.1111/bph.17317.
International Union of Basic and Clinical Pharmacology. CXXI. Apelin Receptor Pharmacology in the Human Cardiovascular System and Emerging Clinical Applications
Davenport AP, Williams TL, Nyimanu D, Macrae RGC, Kuc RE, Chapman FA, Yang P, Dhaun N, Maguire JJ. (2025) Pharmacol Rev. 78(3):100130. doi: 10.1016/j.pharmr.2026.100130.
International Union of Basic and Clinical Pharmacology. CXX. γ-Hydroxybutyrate protein targets in the mammalian brain-beyond classic receptors
Wellendorph P, Gauger SJ, Andersen JV, Kornum BR, Solbak SMO, Frølund B (2025) Pharmacol Rev. 77(4):100064. doi: 10.1016/j.pharmr.2025.100064.
International Union of Basic and Clinical Pharmacology. CXIX. Fundamental Insights and Clinical Relevance Regarding the Carnitine Palmitoyltransferase Family of Enzymes
Rodríguez-Rodríguez, Rosalía et al. (2025) Pharmacol Rev. 77(3):100051. doi: 10.1016/j.pharmr.2025.100051.
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