Health And Financial Wellness Family

Water Revs Up the Brain

Terry.Azeltine@msn.com — Sun, 22 Jan 2012 14:56:04 PST

Posted: 19 Jan 2012 03:23 PM PST

Even mild dehydration can affect mood and concentration, according to study

Forget the caffeinated buzz of that morning cup of Joe, soda pop, or energy drink—water, plain water, could be all your brain needs for a real pick-me-up.
The brain may be a remarkably complex organ, but it requires water for every one of its cells and their function. Now, research from the University of Connecticut has found that keeping the brain completely hydrated is critical for its happy performance.
In a crossover study, 25 young women performed 40 minutes of treadmill walking in a warmed room as part of three experiments: 1) exercise-induced dehydration plus a placebo; 2) exercise-induced dehydration plus a diuretic; 3) and normal hydration with placebo. The researchers documented the women’s moods and their cognitive function during and after the activity.
The authors report that there were negative affects to vigor, fatigue, and mood after only mild dehydration, which equaled a 1.36 percent drop in body mass from water loss. A 2 percent drop in body mass from water loss is the “red flag” for full-blown dehydration. Also, the subjects’ perception of task difficulty and headache severity increased and their ability to concentrate decreased with just mild hydration.
While the cause of the mood changes is still under discussion, the importance of hydration is not. For the first time, this study shows that mood and concentration can be negatively impacted by a nearly insensible water loss. Simply drinking adequate amounts of water may help maintain mood and fight fatigue.
“This study demonstrates that, not only at rest but also during moderate exercise, a wide variety of adverse changes occur in slightly dehydrated, young, healthy females,” the researchers wrote In the December issue of the Journal of Nutrition. "Maintenance of optimal hydration is essential to ensure optimal mood and reduce symptoms."
How much water should a person drink daily to prevent mild dehydration? The actual amount can depend on a number of factors including bodyweight, climate, and activity. Water is lost continually through breathing, sweating, urination, and bowel movements.
Standard advice is to drink around eight 8-ounce glasses of water a day. A truer method is to take half a person's bodyweight in pounds, then divide by half, and drink that much in ounces. On hot days or if performing physical activity, drink a few ounces more or, better yet, drink a sports drink like Want More Energy?® (containing no caffeine or stimulants) that also replenishes lost glycogen, vitamins, and electrolytes.
Based on the conclusions of this study, another approach may be to drink water whenever feeling a lack of energy, sluggish, or a little blue. Keeping an extra glass handy may be all it takes to keep mood and concentration up, leaving you feeling at your best.
Reference: Armstrong LE et al. Mild Dehydration Affects Mood in Healthy Young Women. J. Nutr 2011; doi: 10.3945/jn.111.142000.

Advancements in Skin Aging: Ageless Renewal Serum

Terry.Azeltine@msn.com — Sun, 22 Jan 2012 14:53:05 PST

Posted: 17 Jan 2012 08:40 AM PST

Trainer: Skin Health Expert Kathy McGowan
Want to have "ageless skin”? Designed by scientists in the field of tissue regeneration, Ageless Renewal Serum supplies Repair-Plex™, the proprietary blend of skin bioactives. The serum promotes greater production of matrix protein, collagen, and elastin to create thicker, younger-looking skin. Learn from Kathy McGowan how to best apply the product to work with your skin to “remember” what it has “forgotten” with age.

Isagenix Presented at World Anti-Aging Medicine Conference

Terry.Azeltine@msn.com — Fri, 30 Dec 2011 05:52:47 PST

Posted: 27 Dec 2011 07:43 AM PST

Robert Watine, M.D.

On the final day of the 19^th World Congress of Anti-Aging Medicine and Aesthetic Medicine in Las Vegas, a roomful of forward-thinking medical professionals gathered to learn about a safe, effective nutritional cleansing system for reducing body fat while preserving muscle.
Robert Watine, M.D., of Port Charlotte, Florida, gave the presentation on Dec. 10, sharing his personal experience in incorporating the Isagenix system as an adjunct therapy to standard medical practice in his own patients. The products, he explained, are a combination of high-protein, nutrient-dense meal replacement shakes on Shake Days, the use of an herbal beverage along with liquid fasting on Cleanse Days, and supplementation with adaptogens.
He presented pre- and post-treatment clinical outcome measures after one and three months of the dietary intervention in several of his patients. Each showed marked improvements after following the system for at least three months—body weight, plasma lipids, liver function, renal profiles, and markers of blood sugar management. No side effects were reported.
Each of the patients reported improved quality of life defined by more energy, better sleep, improved concentration, and/or better athletic performance.
"This is of real significance," Dr. Watine said. "This is quality of life improvement doing nothing other than changing a way you eat. Eating more correctly, giving the body what it needs."
Fat Loss and Muscle Anabolism
Dr. Watine said the patients using the system lost body fat while maintaining or, when combined with resistance exercise, gaining lean body mass. The system works, he said, by incorporating nutrition that promotes muscle anabolism and cellular cleansing, and facilitating fat loss through cellular pathways that increase the number of mitochondria in cells. Optimizing muscle size (sarcomere volumization) the Isagenix way, Dr. Watine says, is the "trick to fat burning."
He told attendees he started using the products in his practice because patients would often come to him saying, "I've tried everything, I eat like a bird, I can't get rid of the body fat."
Obesity can complicate most chronic diseases, including cardiovascular disease, diabetes, chronic obstructive pulmonary disease (COPD), and asthma. The integration of Isagenix products into mainstream medical practice for reducing obesity can improve clinical outcomes.
The products had now improved the quality of life in hundreds of his patients. "It's quite impressive," Dr. Watine said.
Dr. Watine practices community based general internal medicine in the office at Southwest Florida Medical Center for Age Management, Wellness and Rejuvenation in Port Charlotte, Florida. He also is on staff at Charlotte Regional Medical Center, Peace River Regional Medical Center, and Fawcett Memorial Hospital.
He graduated from University of Miami School of Medicine in 1985, completing his internship and residency at Mount Sinai Medical Center from 1985 and 1988. He is a Diplomate of the American Board of Internal Medicine.
The World Congress of Anti-Aging Medicine and Aesthetic Medicine is a conference organized by the American Academy of Anti-Aging Medicine (A4M). A4M is comprised of 22,000 or more members from 105 nations worldwide. The organization promotes advancement and research into methods to optimize the human aging process.

How Does Whey Protein Signal Muscle Growth?

Terry.Azeltine@msn.com — Mon, 26 Dec 2011 08:06:18 PST

Posted: 22 Dec 2011 01:18 PM PST

Scientists have found the signaling pathway of muscle growth induced by combination of whey protein and weight training

Sports physiologists know that maximizing muscle building requires adequate amounts of high-quality dietary protein—rich in branched-chain amino acids such as leucine—and a resistance training regimen such as weight lifting. Less known are the precise cellular and molecular signals that explain how these factors promote muscle growth.
A new study from New Zealand and Australian scientists reports that leucine-rich whey protein combined with resistance exercise stimulates muscle growth in young and older men by way of increasing the activation of molecular modification (mTOR signaling) of muscle proteins. Interestingly, while the combination of exercise and whey protein increased activation of some muscle proteins to a similar degree in young and old before training, the diet/exercise combination was distinctly blunted in the older subjects.
According to the authors of the study, just published in the journal Applied Physiology, Nutrition and Metabolism, while exercise and whey protein combined to effectively activate muscle proteins in young men, deficiencies in this signaling pathway were evident in muscles from older individuals.
"Strategies to improve muscle growth in the elderly should not dismiss the use of protein, particularly whole proteins high in leucine [such as whey protein], in conjunction with a resistance exercise program," the researchers wrote.
The researchers compared the impact of whey protein supplementation (27 grams consumed after each of 36 resistance training sessions over 12 weeks) or a placebo on cell signaling protein activation. They also addressed the effects of aging on these specialized proteins by examining muscle from young (ages 18 to 25) and older (ages 60 to 75) males before and after the 12-week training program. The importance of understanding muscle growth and maintenance in aged individuals is particularly important considering the prevalence of sarcopenia (age-related muscle loss) in elderly populations.
With this in mind, the IsaLean Shake containing 23 grams of protein per serving made up of primarily whey and IsaPro providing18 grams of whey protein per serving can be used advantageously by young and elderly for maximizing the signaling needed for maintaining or stimulating muscle growth when consumed along with a resistance training program.
Reference: Farnfield MM et al. Activation of mTOR signalling in young and old human skeletal muscle in response to combined resistance exercise and whey protein ingestion. Appl Physiol Nutr Metab 2011 Dec 13. doi: 10.1139/h11-132

Teens Eat Too Little Fruits, Vegetables

Terry.Azeltine@msn.com — Wed, 07 Dec 2011 16:26:47 PST

Posted: 05 Dec 2011 10:30 AM PST

A recent CDC report highlights the lack of fruits and vegetables in the diets of teenagers

As any parent understands, getting teens to eat healthy—as in getting adequate servings of fruits and vegetables—is nothing short of a battle. Now, a new report from the U.S. Centers for Disease Control and Prevention (CDC) points out that the average amount of fruits and vegetables eaten by high school students is only 1.2 servings a day.
The report, published in a November issue of the CDC’s Morbidity and Mortality Weekly Report, analyzed data from more than 10,000 high school students (grades 9 through 12) that participated in the National Youth Physical Activity and Nutrition Study 2010. The results showed that about one third (33.2 percent) of students ate less than one vegetable serving a day and more than a quarter (28.5 percent) ate less than one fruit serving a day.
A gender, age and ethnic disparity also exists when it comes to students' fruit and vegetable consumption. Teenage boys were more likely to meet recommendations than teenage girls, younger teens more likely than older teens, and black and Hispanic students ate the lowest amount of vegetables.The recommended number of servings of fruits and vegetables for teenagers ranges from 3 to 6, depending on the gender of the child and how much physical activity they get. According to the results of the study, however, less than 20 percent of students ate fruits and vegetables in line with recommendations.
“The infrequent fruit and vegetable consumption by high school students highlights the need for effective strategies to increase consumption,” the authors wrote.
So what’s a parent of a high-schooler to do? To start, the fight for teens to eat healthy should never be abandoned. Experts suggest exposing teens to as many fresh fruits and vegetables as possible, and for parents to eat them too. Even though they are teenagers, they’re still impressionable.
And for an easy way to boost a teen’s diets with the antioxidant equivalent of more than 20 fruits and vegetables, give teens IsaFruits and Isagenix Greens!. These convenient powder-drinks mix easily in just about any beverage and will help with giving teens the fruit-and-vegetable-derived nutrients they greatly need.
Reference: U.S. Centers for Disease Control and Prevention, news release, Nov. 25, 2011

Feeling Sluggish? Power Up With Protein

Terry.Azeltine@msn.com — Sat, 03 Dec 2011 08:20:12 PST

Feeling Sluggish? Power Up With Protein

Posted: 29 Nov 2011 04:15 PM PST

Eating protein may help fight after-meal fatigue, study finds

We all know the feeling of an afternoon crash: eyes struggling to stay open, concentration drifting to thoughts of snuggling up in bed, and overall energy zapped. Sugar (glucose) may be the body’s main fuel for energy, but now a new study suggests that protein should be what we eat at lunch to help us stay awake and burn calories for the rest of the afternoon.
University of Cambridge researchers compared the effects of different nutrients on neurons in mouse brains. Wakefulness and calorie burning are dependent on secretion of a neuropeptide, orexin. When neurons don’t secrete enough orexin, sleepiness ensues—which can lead to fewer calories burned and more weight gained over time.
When the scientists measured the actions of protein (amino acids), carbohydrate (glucose), and fat (fatty acids) on the neurons, they found that the amino acids stimulated the cells to secrete orexin to a much greater extent than the other nutrients. In prior studies, the researchers found that orexin-secreting neurons are blocked by glucose. But, when interactions between glucose and protein were looked at in this study, the researchers found that protein prevents glucose from blocking the orexin secretion.
The results, published in the November issue of the journal Neuron, may help explain why people may feel particularly sleepy after eating meals rich in carbohydrates. Meals higher in protein and lower in total carbohydrates could help maintain alertness over the course of the day.
“What is exciting is to have a rational way to ‘tune’ select brain cells to be more or less active by deciding what food to eat,” said lead researcher Denis Burdakov in a University of Cambridge press release. “Not all brain cells are simply turned on by all nutrients, dietary composition is critical.”
“To combat obesity and insomnia in today’s society, we need more information on how diet affects sleep and appetite cells. For now, research suggests that if you have a choice between jam on toast, or egg whites on toast, go for the latter! Even though the two may contain the same number of calories, having a bit of protein will tell the body to burn more calories out of those consumed.”
Better yet, get your energizing dose of protein with IsaLean Shake, Bars, or Soups (and, for an even bigger protein boost, added IsaPro to your shake) at breakfast and lunch; and instead of an afternoon crash, you’ll be heading for an afternoon take-off. You'll burn more calories too.
Reference: Karnani MM, Apergis-Schoute J, Adamantidis A et al. Activation of central orexin/hypocretin neurons by dietary amino acids. Neuron 2011;72:616-29. doi: 10.1016/j.neuron.2011.08.027

Cleanse Days Combat Weight Gain and Oxidative Stress

Terry.Azeltine@msn.com — Wed, 23 Nov 2011 15:04:34 PST

Cleanse Days Combat Weight Gain and Oxidative Stress

Posted: 22 Nov 2011 10:47 AM PST

One or two days a week of Cleanse Day-style calorie reduction similar if not more beneficial than dieting for shedding weight and oxidative stress, study suggests.

Worried you might eat too much at Thanksgiving or during the holiday season? Following the festivities with a couple of Cleanse Days is an effective way to get back on track by compensating for the extra calories eaten. Results from a study published recently in the International Journal of Obesity show just that.
In a randomized trial on 107 middle-aged, overweight or obese women, researchers compared intermittent calorie restriction—similar to Cleanse Days on an Isagenix system—with continuous calorie restriction (regular dieting). It was one of the first human trials to ever compare the two weight-management strategies. Over the six-month study, researchers took measurements including weight, total body fat, blood pressure, and blood sampling to determine changes in weight and insulin resistance.
The study assigned the women to either consume a continuous calorie-restricted diet (25 percent below estimated requirements daily) or a diet that restricted calories by 75 percent for two days a week, the other five days followed the estimated requirements for weight maintenance.
The women in the calorie-restricted group followed a Mediterranean-type diet. The diet contained 30 percent calories from fat (most being monounsaturated fat like olive oil as found in IsaLean Shake), 45 percent calories from low-glycemic carbohydrates, and 25 percent calories from protein. The intermittent calorie-restriction group followed the same diet, but for two days consumed only about 492 to 541 calories each day—that's not quite as low in calories as the average Cleanse Day of about 150 calories daily, but it's pretty close.
At the end of the six months, the researchers found that both groups were comparable in total weight loss and improvements in several risk markers for type 2 diabetes, cardiovascular disease, and several cancers. However, the intermittent calorie restriction group appeared to have greater improvements in insulin sensitivity and oxidative stress markers.The increased insulin sensitivity from intermittent calorie restriction may be related to the significant decrease of insulin in the body during a one-or-two-day reduced intake in calories, which was followed by regular calorie intake. The authors called for future trials that look into the effects that intermittent calorie restriction has on insulin and glucose metabolism.
They wrote, intermittent calorie restriction “may be offered as an equivalent alternative to” dieting “for weight loss and reducing disease risk.”
Previously, research reviews have also speculated that intermittent calorie restriction might be linked to better disease prevention than continuous fasting because of increased resistance to oxidative stress—results from this study may support this assertion.
For those on an Isagenix system, these findings support the importance of Cleanse Days. They may offer similar if not more benefits than regular dieting for weight loss. Unlike normal intermittent calorie restriction, drinking Cleanse for Life also supports the body nutritionally, adds antioxidant protection, and promotes detoxification because of its content of herbs, vitamins, and minerals.
Reference
Harvie MN, et al. The effects of intermittent or continuous energy restriction on weight loss and metabolic disease risk markers: a randomized trial in young overweight women. Int J Obes (Lond) 35.5 (2011): 714-27. doi:10.1038/ijo.2010.171

Multivitamins May Support Memory in Older Women

Terry.Azeltine@msn.com — Sat, 19 Nov 2011 06:40:10 PST

Posted: 17 Nov 2011 12:46 PM PST

Older women taking a multivitamin-mineral-herb supplement maintain better memory, study finds

We all forget things from time to time, but as we get older, the continued occurrence of misplacing keys or forgetting that phone number you’ve dialed countless times becomes more and more unwelcome, and even scary. But is there anything that can be done to equip our memory to withstand the perils of age?

According to a new randomized controlled study from Australia, taking a combined multivitamin, mineral, and herbal supplement — with similar ingredients found in Ageless Essentials Daily Pack with Product B — may help maintain memory in older women.
The study, published in Psychopharmacology, investigated the effects of multivitamin supplementation on cognition in 56 elderly women who had complaints of memory loss. Study participants were split into two groups; one group took a daily multivitamin consisting of antioxidants and minerals with added herbal and plant extracts, and the other group took a daily placebo.
After 16 weeks, the researchers from the NICM Collaborative Centre for Neurocognition at Swinburne University of Technology in Melbourne found that compared to the placebo group, the women who took the multivitamin supplement had a significant improvement in spatial working memory and decreased levels of homocysteine, an amino acid that’s harmful in high amounts in the body. The multivitamin users also had higher levels of vitamins B_6,B_12,and E than the placebo group.
“It is conceivable that by increasing these nutrients via dietary supplementation, there may be a beneficial effect on the function and integrity of the nervous system,” wrote the Australian researchers. They added, “In addition to lowering oxidative stress, it has been suggested that fat soluble antioxidants such as vitamin E may also exert direct effects on the brain.”
Outside the ingredients mentioned above and those typically found in most multivitamins, the study supplement included antioxidants such as coenzyme Q10 (coQ10); herbal and plant extracts such as milk thistle, grape seed, turmeric, ashwagandha, bilberry, and bacopa; and probiotics such as Lactobacillus acidophilus.
More than just a multivitamin, Ageless Essentials Daily Pack with Product B contains essential vitamins and minerals, coQ10, milk thistle, turmeric, bacopa, ashwagandha, grape seed, and turmeric. In addition, Isagenix Ionix Supreme and Cleanse for Life provide doses of ashwagandha, bacopa, turmeric, and bilberry.
As the study suggests, supplementing with multiple vitamins and minerals, in addition to herbal and plant extracts, looks to be beneficial for that very important part of life called memory. This multi-dimensional approach is also what keeps health and well-being at the optimal level.
Reference: Macpherson H, Ellis KA, Sali A, Pipingas A. Memory improvements in elderly women following 16 weeks treatment with a combined multivitamin, mineral and herbal supplement : A randomized controlled trial. Psychopharmacology (Berl) 2011. doi: 10.1007/s00213-011-2481-3

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Practice Safe Sun Exposure? Take a Vitamin D Supplement

Terry.Azeltine@msn.com — Thu, 17 Nov 2011 03:00:56 PST

Posted: 15 Nov 2011 05:49 AM PST

Seeking shade or wearing long sleeves may lower vitamin D levels

For decades, dermatologists have sounded the alarm regarding the deadly effects of excessive sun exposure on incidence of skin cancers. Unfortunately, along with admonishing people to "stay out of the sun," comes a downside: a suboptimal level of vitamin D in the body.
Vitamin D, originally assumed to be necessary for only bone development, has now undergone a renaissance in the scientific community. Whether talking about bone health, brain health, blood sugar control, or any other symptom associated with aging, vitamin D is certainly a “hot nutrient”.
While the “no sun” versus “limited sun” doctors continue to fight it out, a new study led by researchers from Stanford University have compared the sun exposure habits of almost 6,000 American adults to their vitamin D status. To obtain this data, the researchers used the US National Health and Nutrition Examination Survey (NHANES) 2003-2006, a continuing governmental program to monitor the nation's health and nutritional status. Sun exposure habits analyzed included staying in the shade, wearing long sleeves, and the level of sunscreen use, among other variables. Vitamin D status was determined by serum levels of 25(OH)D (the active circulating form of vitamin D) with concentrations under 20 nanograms per milliliter (ng/ml) considered vitamin D deficient.
The researchers found that white individuals who protected themselves from sun exposure by either frequently seeking shade or frequently wearing long sleeves had significantly reduced levels of 25(OH)D compared to those who rarely engaged in either habit.
In their paper, published in Cancer Causes Control, the authors noted that while the “magnitude of the 2-4 ng/ml difference in 25(OH)D associated with frequent shade and long sleeve use is modest,” it “approximates the increase in 25(OH)D levels achieved with 200-400IUs of oral vitamin D supplementation and is comparable with the increases achieved in some vitamin D supplementation trials that found health benefits.” Neither Hispanics nor blacks had a similar association, although there was a trend towards significance for both groups.
Interestingly, sunscreen was not associated with vitamin D deficiency; a finding the researchers speculated may have been attributed to either inadequate application or inconsistent use of sunscreen products. They also found that wearing a hat was not associated with vitamin D deficiency.
So what to make of this study for the average American? One thing is clear: Since vitamin D is found in remarkably few foods, and since too much sun exposure definitively causes DNA damage, the best option for optimal vitamin D intake lies in adequate consumption of both foods enriched with the “sunshine” vitamin, along with a quality supplement containing adequate amounts of the vitamin to ward off age-associated deterioration of the bone, heart, brain, and immune systems.
Aren’t you glad Isagenix products include healthy amounts of vitamin D in products such as Ageless Actives, Ageless Essentials Daily Pack, Essentials for Men and Women, and IsaLean Shakes?
Reference: Linos E et al. Sun protective behaviors and vitamin D levels in the US population: NHANES 2003-2006. Cancer Causes Control; 2011 Nov 2. doi: 10.1007/s10552-011-9862-0
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Five Things You Should Really Look for In a Multivitamin

Terry.Azeltine@msn.com — Fri, 11 Nov 2011 13:22:46 PST

Posted: 07 Nov 2011 04:10 PM PST

Choosing a quality multivitamin is easier with a few guidelines

Choosing a multivitamin-mineral supplement can be puzzling. Conflicting messages abound in the marketplace, especially on the Internet. And, as expected, the confusion is not helped by reports from the media that tend to overemphasize observational studies that confirm bias against supplementation. The reality is that the quality of multivitamin-mineral supplements ranges widely.
The highest quality dietary supplements are those designed according to current science and technologies—they use the most stable and efficacious forms of vitamins and minerals, have optimal solubility rates, are third-party tested for potency and shelf life, and provide optimal vitamin-and-mineral dosages that are divided over the course of the day for best absorption.
On the other end of the quality spectrum are the popular "one-a-day" supplements, which claim to provide all that the body needs in a single tablet; they may provide adequate amounts of many nutrients, but severely neglect others. Other supplements use synthetic vitamins when science demonstrates the body's preference for the natural forms. Finally, some supplement companies claim higher absorption or bioavailability because their nutrients come directly from, or are paired with, “whole foods”; such claims are misleading because they are not presented with data. These vitamins do not actually come from whole foods, but are simply combined with botanicals that may even inhibit absorption.
Far be it for all marketers to paint a clear picture of the science, or for the media to do a little homework before lumping all dietary supplements in the same category of low quality and worthless. The fact is though, that there have been well-designed studies showing clear benefits from taking supplements in forms appropriate and in dosages that assist in meeting dietary recommendations for optimal health. If this weren’t true, or if multivitamins were somehow “dangerous”, then why do most medical doctors continue prescribing prenatal multivitamins to women who are expecting?
A proper review and critique of multivitamin-mineral supplements should be based on how well it reflects positions of scientific consensus on dosage, forms, and delivery. A few of the things to look for in a supplement are these:

Quality – According to a recent Consumer Labs report, one in three supplements either contained fewer nutrients than promised on the label, provided far more nutrients than claimed, had incorrect labeling of ingredients, or simply failed to disintegrate in the allotted time for proper absorption. If uncertain about whether or not a supplement really provides what it claims to, it’s probably a supplement to avoid. Take a multivitamin-mineral only if it comes from a reputable company that tests label claims through an independent laboratory.
Efficacy – It’s well-known that some forms of vitamins or minerals are more stable, or more bioavailable, than others. For example, natural vitamin D3 exhibits greater retention in the body compared to synthetic vitamin D2 (1). Likewise, vitamin E in its natural form of d-alpha tocopherol provides greater activity than its synthetic mixture counterpart, dl-alpha tocopherol, which contains only a small percentage of the natural form (2). Another example is vitamin B12 as cyanocobalamin, which is more stable than other forms of vitamin B12, thus allowing for greater shelf life.
Optimal dosages – Multivitamin-mineral supplement makers will often add a mineral such as calcium or an antioxidant such as coenzyme Q10 (CoQ10) to help it sell better in the marketplace, but not in high enough doses to really strengthen bones or support the heart. Such supplements should be avoided in favor of others that actually supply enough of each nutrient to truly be effective. Similarly, should a supplement contain omega-3 fatty acids, it should contain a high enough concentration of both DHA and EPA for heart health. In short, dosages should reflect the latest that science has to offer as recommendations for health and longevity.
Solubility – Have you heard of “bed pan bullets”? That’s what doctors used to call tableted multivitamin pills that passed through the body unabsorbed. Science has come a long way to provide technologies for better solubility, but there still are a few multivitamins on the market that don’t disintegrate appropriately enough to be absorbed properly. The standard for a quality multivitamin-mineral tablet is to disintegrate within 60 minutes or less in an acidic solution mimicking the environment in the stomach—even better is if it can disintegrate easily in plain water or rice vinegar.
Absorption and bioavailability – Companies make misleading claims when they market their supplements as more highly absorbed or bioavailable because they are from, or combined with, “whole food” or “vegetable components.” For one thing, the source of their vitamins is really not different than anyone else’s, which is obtained through yeast fermentation. The “whole-food” source supplements also seldom meet label claims or stability for shelf life. In addition, they don’t account for anti-nutrient components; for example, a supplement containing leafy green vegetables such as spinach may also contain anti-nutrient compounds called oxalates that inhibit absorption of other minerals in the supplement through chelation (that’s not to say people should avoid eating spinach, but that improved absorption and bioavailability from a spinach supplement is false) (3). There are also supplements on the market (obviously not designed by nutritionists familiar with the science) that completely disregard well-known absorption problems when dosages of minerals such as calcium are too high, or when mineral competitiveness occurs between iron, calcium, zinc, and copper (3 & 4). A quality supplement will use forms of minerals without absorption-inhibiting anti-nutrients and have an appropriate amount of minerals in each tablet to be taken in divided doses over the course of the day.

Before ever venturing out to choose a multivitamin-mineral, each of the five points presented above should be considered by those looking to achieve the greatest value from their supplements. All things considered, our choice is Ageless Essentials Daily Pack, which comes in convenient A.M. and P.M. packets. Over the course of the day, the pack provides optimal dosages of essential vitamins and minerals such as vitamin D3 (2000 IU), calcium (800 mg for men, 900 mg for women), vitamin E as mixed tocopherols and d-alpha tocopheryl succinate (90 IU), and vitamin K2 (80 mcg).
The pack also includes a potent combination of bioactive compounds that support optimal health and longevity. These include patented, lipid-soluble CoQ10 (100 mg) backed by studies showing eight times greater bioavailability, maximum concentrations of ultra-purified DHAand EPA omega-3 fatty acids (600 mg EPA, 440 mg DHA), trans-resveratrol (250 mg), and more.
Add in Product B to the order—Ageless Essentials with Product B—and as clearly displayed on every box, “Imagine adding life to your years with an increased feeling of youth, health and vitality.”
References

Food and Nutrition Board. Institute of Medicine. Dietary Reference intakes. Washington, DC: National Academy Press, 2000, pp. 186-283.
Heaney R et al. Vitamin D3 is More Potent Than Vitamin D2 in Humans. J Clin Endocrin & Metab. 2011;96(3):E477 doi: 10.1210/jc.2010-2230
Gropper SS, Smith JL, Groff JL. Advanced Nutrition and Human Metabolism. Belmont, CA: Thomson Wadsworth, 2009.
Hoffman H et al. Zinc-induced copper deficiency. Gastroenterology 1988; 94:508-12.

Meals with Higher Percent Protein Can Help Control Overeating

Terry.Azeltine@msn.com — Thu, 10 Nov 2011 15:32:26 PST

Posted: 09 Nov 2011 02:23 PM PST

Study finds eating meals lower in percent protein may lead to overeating

Worried about overeating high-calorie goodies during the upcoming holidays and piling on the pounds? Eating foods with a higher percent of calories from protein may be all it takes to help control appetite and manage weight, a new study suggests.
Researchers from the University of Sydney in Australia, Cambridge University in the United Kingdom, and Massey University in New Zealand found that lean adult men and women fed foods containing 15 or 25 percent calories from protein over a four-day period ate 12 percent fewer calories overall than subjects fed foods containing 10 percent calories from protein.
The study, published in PLoS One in October, also found that the subjects fed the lower protein (10 percent) diet reported they were hungrier after breakfast in comparison to those fed a higher (25 percent) protein diet.
“In our study population a change in the nutritional environment that dilutes dietary protein with carbohydrate and fat promotes overconsumption, enhancing the risk for potential weight gain,” the authors wrote.
“Protein Leverage Theory”
When placing blame on contributors to the increasing obesity epidemic in the United States, the usual suspects that come to mind are easy access to high-calorie foods and too little time spent exercising. This study was designed to test a “protein leverage theory”, which proposes that when faced with a diet lacking enough protein—a more hunger-satisfying nutrient— people compensate by overeating.
The protein leverage theory is not far-fetched—studies in other species including non-human primates, pigs, rodents, birds, fish, and insects all consistently show that when the percentage of protein is reduced in their diets, they compensate by eating more calories from non-protein sources such as carbohydrate and fats.
Between 1961 and 2000, the protein percentage in Americans’ diets declined from 14 percent to 12.5 percent. Although it’s less than a 2 percent drop, it was paired alongside a 14 percent increase in total caloric intake from fat and carbohydrate.
Study Design
Twenty two healthy, lean men and women participated in three, four-day study sessions where the subjects stayed overnight and had all meals provided and their eating habits monitored.
The recipes for the foods made were modified to contain 10, 15, or 25 percent calories from protein. Fat was kept constant at 30 percent, and carbohydrate was also modified to be 60, 55, or 45 percent of calories. The study’s meals were prepared in a way so the participants could not tell the difference in the fat, carbohydrate, or protein content of the foods eaten. Meals served included apricot yogurt muesli for breakfast, teriyaki sushi roll for lunch, and chow mein for dinner. Outside of meals, snack foods, or ‘anytime foods’, were also available to the participants whenever they liked, and these were either sweet or savory options—carrot cake, apple crumble muffins, and cheese scones among the choices.
When comparing what subjects ate on the 10 percent protein diet versus the 15 percent protein diet, researchers found that subjects consumed an average of 12 percent more calories over the 4-day session. Of that 12 percent increase, 57 percent was due to eating more savory foods, and 43 percent due to eating more sweet foods.
The authors noted that 70 percent of the caloric increase in the subjects on the 10 percent protein diet came from eating foods that were available anytime (snack foods). The increase in calories was evident from the first day of the trials and persisted throughout.
“If subjects maintained the level of increased intake observed on the 10 percent protein diet in our study, without an accompanying increase in energy expenditure through increased activity,” the authors wrote, “a 1.0 kg [about 2 pounds] weight increase per month would be expected.”
IsaLean Shake and IsaPro
One convenient way to obtain hunger-satisfying protein is IsaLean Shake. The complete meal replacement contains only 240 calories, of which more than 35 percent comes from high-quality protein.
The high-protein shake is clinically shown to promote healthy weight loss, help maintain or build muscle when combined with exercise, and help maintain healthy blood sugar levels.
Vanilla IsaPro whey protein is another product that can be enjoyed by adding one scoop to one and a half scoops of IsaLean Shake, or mixed into recipes (like this one). Whey protein is ideal for boosting fat burning and promoting muscle maintenance.
Reference: Gosby AK, Conigrave AD, Lau NS et al. Testing protein leverage in lean humans: a randomised controlled experimental study. PLoS One 2011;6:e25929. doi: 10.1371/journal.pone.0025929
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B Vitamins May Help to Keep the Brain Fit

Terry.Azeltine@msn.com — Sat, 05 Nov 2011 15:07:05 PDT

Posted: 01 Nov 2011 04:39 PM PDT

Supplementation with B vitamins slows cognitive decline in elderly, study suggests

“Brain fitness” can be described as doing any number of things that help the mind stay active and keep a mental edge throughout life. There’s been a lot of focus on activities that keep the mind busy, such as crossword or Soduko puzzles, and now even some video games are specifically designed to stimulate our brains. But the focus also needs to be on sound nutrition, and according to a new clinical study, daily supplementation with B vitamins may also help slow down the age-related mental decline we’d all like to avoid.
The study, led by researchers from both the University of Oxford and the University of Oslo, found that a daily supplement in people with mild cognitive impairment (MCI) that combined folic acid along with vitamins B6 and B12 was associated with reduced levels of homocysteine, an amino acid that increases with age and is linked to declining mental function when present in high amounts. The B-vitamin cocktail also improved certain aspects of mental function in those who took them.
The study included 223 people over age 70 with MCI. The subjects were randomly assigned to one of two groups: a placebo group or a group receiving the B-vitamin supplement. Following the two-year trial, levels of homocysteine increased in the placebo group but fell significantly in the group supplementing with B vitamins. Additionally, those in the placebo group had more cognitive decline in comparison to the supplemented group.
Not surprisingly, the most dramatic effects were seen in those subjects who started with the highest levels of homocysteine. For those taking B vitamins with lower amounts of blood homocysteine levels, the rate of brain atrophy was reduced by 30 percent; those with higher levels of homocysteine reduced their rate of brain atrophy by 53 percent.
When considering the data, the researchers wrote, “One interpretation is that lowering homocysteine concentrations by administering B vitamins slows brain atrophy [wasting in the brain], which in turn slows both cognitive and clinical decline.”
The authors conclude, “Our data indicate that B vitamins may slow cognitive and clinical decline in participants with MCI, in particular those who have high tHcy [homocysteine] concentrations.”
This study corroborates recent epidemiological evidence from Rush University Medical Center in Chicago, which found that individuals with lower levels of vitamin B12 are more likely to have smaller brains and score more poorly on cognitive skills tests (see more info here).
MCI affects about 16 percent of those over the age of 70, or about 5 and 14 million people in the US and Europe, respectively. The researchers defined MCI as “cognitive decline greater than that expected for an individual’s age and education level but that does not interfere notably with activities of daily life.”
Regardless of age, this study underlies the very good reason to get adequate B vitamins in the diet throughout all stages of life. It very well may help to keep your brain fit.
Reference: de Jager CA, Oulhaj A, Jacoby R, Refsum H, Smith AD. Cognitive and clinical outcomes of homocysteine-lowering B-vitamin treatment in mild cognitive impairment: a randomized controlled trial. Int J Geriatr Psychiatry 2011. doi: 10.1002/gps.2758
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Athletes: Five Supplements to Protect Joints

Terry.Azeltine@msn.com — Wed, 02 Nov 2011 03:20:18 PDT

Posted: 17 Oct 2011 12:27 PM PDT

The right supplements can guard joints against heavy demands of sports like running.

By Dr. Michael Colgan (abstracted and adapted from Dr. Colgan’s forthcoming book, The Anti-inflammatory Athlete)
The more complex a joint, the more likely it will get injured in sport. Knees are the most complex. They consist of a rolling cam that also rotates as it rolls. No surprise that knees are the joint most subject to injury. There are more than three million knee injuries every year in young athletes in the US alone, in all sports played on the feet (1).
Close in vulnerability to the knee is the ankle, with its simultaneous hinge, gliding, and rotating action. Next in vulnerability is the shoulder, with its hard ball head of the humerus bone sliding precariously in a depression in the soft tissue that it uses as a shallow socket. Then come the vulnerable hinge and gliding joints of the elbow and wrist.
The hard bone ball and bone socket of the hip joint is the most robust. Nevertheless, all these synovial joints rely on the integrity of their cartilage for healthy movement. Cartilage is the soft tissue layer on either side of the joint that cushions the ends of the bones. Bones have a slick of synovial fluid between them that lubricates the moving parts and enables them to slide freely.
Sport is tough on cartilage, continually creating rough spots and wearing it out. Sport is also tough on the synovial fluid. Whenever the intensity of your exercise causes the rate of wear and tear to exceed the maximum rate at which you can produce new cartilage and synovial fluid, you get inflammation, pain, and stiffness of the joints (2). Here we will tell you how to increase your maximum rate of renewal of cartilage and synovial fluid so you can maintain it indefinitely.
There are four essential components of a synovial joint that you can influence by what you eat. First are collagen fibrils. Second, are structures like small feathers called proteoglycans. Third, are chondrocytes, the only cells in cartilage. Chondrocytes manufacture the mix of collagen and proteoglycans that form the cartilage.
Fourth is synovial fluid, a complex mixture that contains a high level of hyaluronan (hyaluronic acid), a viscous gel. Hyaluronic acid is the water-holding molecule of the body. One gram will hold more than a thousand grams of water. Its gel structure retains the water that cushions nerves and joints, and also provides the shape and form to the human eye and skin. A 70kg (154 lbs) athlete has about 15 grams of hyaluronan in the body, one-third of which is degraded and replaced every day. The harder you exercise the more hyaluronan you use. Decline of hyaluronan with aging, and not collagen as frequently claimed, is the main cause of wrinkles and lines. For free moving joints athletes need to get its components in their diet every day.
Science has discovered natural substances that speed the body's processes of renewing cartilage and synovial fluid, and inhibit their decline. Here we cover only the best of those substances that research shows improve cartilage and lubrication of joints in controlled trials.

Collagen- Athletes certainly need the extra collagen in their joints, and should do everything that can maintain it. Athletes can preserve collagen levels in joints by eating a diet high in free-range poultry, wild fish, and shellfish or through supplementation (3-5). In addition, one of the big reasons we advise strongly against NSAIDs use, especially before exercise, is that these drugs abolish the rise in adaptive collagen that occurs in rhythmic exercise such as running (6).
Glucosamine sulfate – A major component of proteoglycans is the chemical glucosamine. Supply of this chemical is the rate-limiting step that largely controls the renewal of proteoglycans, and thus the rate of cartilage renewal (2). Preformed glucosamine taken as a dietary supplement increases glucosamine levels in joints (7-13).
Chondroitin sulphate – Taken as a supplement, chondroitin sulfate has been successful in increasing the quality and volume of new cartilage in numerous controlled trials over the last 20 years (13-17). From the research overall, we recommend that athletes routinely use glucosamine sulfate and chondroitin sulfate daily. We recommend doubling normal doses of each daily when doing intense training, such as runs longer than 15 miles in preparation for a marathon, or the four weeks before a big game.
Hyaluronan- A major component of the synovial lubricating system of joints is hyaluronan. For 50 years, researchers have been using various formulations of hyaluronic acid to determine if it will increase production of synovial fluid. The big problem has been absorption, because hyaluronic acid is usually a whopping molecule, seemingly too big to pass through the gut wall. So the usual therapy used with patients involves injecting the hyaluronan directly into the joints. Some oral formulations now offer small molecule hyaluronan to overcome the absorption problem. Recent reviews of the evidence, however, indicate that even large molecule hyaluronan taken by mouth does increase synovial fluid in joints (7). From this research, we recommend supplementation of hyaluronic acid for athletes.
Methyl-sulphonyl-methane (MSM) – To make new cartilage, the body also needs a lot of sulfur, which is likely why the sulfate form of glucosamine is the most successful in creating cartilage. Combined with alliums in the everyday diet to increase availability of sulfur, we have had great success with runners, especially for knee pain. If you are not getting sufficient alliums, that is onions, garlic, or leeks every day, then we recommend daily supplements of basic sulfur as MSM. There is considerable evidence supporting MSM supplementation (11, 19). If you are going to be a champion resolve today to nurture perfect joints.

Note: Each of these supplements is represented in Isagenix Ageless Joint Support tablets, which are designed to provide triple-action support for athletes by protecting, rejuvenating, and soothing joints. The tablets are a component of our Rejuvity Joint and Pain Relief System.

References

Adirim TA, Cheng TL. Overview of injuries in the young athlete. Sports Med. 2003;33(1):75-81.
Colgan M. Beat Arthritis. Vancouver: Apple Publishing, 2000.
Bello AE, Oesser S. Collagen hydrolysate for the treatment of osteoarthritis and other joint disorders: a review of the literature. Curr Med Res Opin 2006 Nov;22(11):2221-2232.
Sreejamole KL, et al. Anti-inflammatory activities of aqueous/ethanol and methanol extracts of Perna viridis Linn. in mice. Inflammopharmacology 2011 Feb 27. [Epub ahead of print]
Halpern GM. Anti-inflammatory effects of a stabilized lipid extract of Perna canaliculus (Lyprinol). Allerg Immunol (Paris). 2000 Sep;32(7):272-278.
Christensen B, et al. Effect of anti-inflammatory medication on the running-induced rise in patella tendon collagen synthesis in humans. J Appl Physiol. 2011 Jan;110(1):137-41.
Bruyere O, et al. Evaluation of symptomatic slow-acting drugs in osteoarthritis using the GRADE system. BMC Musculoskelet Disord 2008 Dec 16;9:165.
Jordan KM. Arden NK. An evidence based approach to the management of knee osteoarthritis: Report of a Task Force of the Standing Committee for International Clinical Studies Including Therapeutic Trials (ESCISIT)”. Ann Rheum Dis 2003;62 (12): 1145–1155.
Leffler CT, et al. Glucosamine, chondroitin, and manganese ascorbate for degenerative joint disease of the knee or low back: a randomized, double-blind, placebo-controlled pilot study. Military Med 1999;164(2):85-91.
Yoshimura M, et al. Evaluation of the effect of glucosamine administration on biomarkers for cartilage and bone metabolism in soccer players. Int J Mol Med 2009;24(4):487-494.
De Silva V et al. Evidence for the efficacy of complementary and alternative medicines in the management of osteoarthritis: a systematic review. Rheumatology (Oxford) 2010 Dec 17. [Epub ahead of print]
Jordan KM. Arden NK. An evidence based approach to the management of knee osteoarthritis: Report of a Task Force of the Standing Committee for International Clinical Studies Including Therapeutic Trials (ESCISIT)”. Ann Rheum Dis 2003;62 (12): 1145–1155.
Black C et al. The clinical effectiveness of glucosamine and chondroitin supplements in slowing or arresting progression of osteoarthritis of the knee: a systematic review and economic evaluation. Health Technol Assess 2009 Nov;13(52):1-148.
Morreale P, et al. Comparison of the anti-inflammatory efficacy of chondroitin sulfate and diclofenac sodium in patients with knee osteoarthritis. J Rheumatol 1996;23:1385-91.
Uebelhart D, et al. Intermittent treatment of knee osteoarthritis with oral chondroitin sulfate: a one-year, randomized, double-blind, multicenter study versus placebo. Osteoarthritis Cartilage 2004 Apr;12(4):269-76.
Leeb BF, et al. A meta-analysis of chondroitin sulfate in the treatment of osteoarthritis. J Rheumatol 2000 Jan;27(1):205-11.
Baeurle SA, et al. Effect of the counterion behavior on the frictional–compressive properties of chondroitin sulfate solutions. Polymer 2009;50(7):1805–1813.
Kalman DS, et al. Effect of a natural extract of chicken combs with a high content of hyaluronic acid (Hyal-Joint) on pain relief and quality of life in subjects with knee osteoarthritis: a pilot randomized double-blind placebo-controlled trial. Nutr J 2008;Jan 21(7):3.
Parcell S. Sulfur in human nutrition and applications in medicine. Altern Med Rev 2002 Feb;7(1):22-44.

Cravings for Junk Food Lessen with Discipline and Time

Terry.Azeltine@msn.com — Sat, 29 Oct 2011 10:21:46 PDT

Posted: 28 Oct 2011 03:41 PM PDT

A new study shows that cravings for high-fat and high-sugar foods do lessen over time

Did you know that cravings for foods like pizza, French fries, doughnuts, and ice cream are the most oft-cited reasons in controlled studies for people not sticking to a weight-management program? In fact, some people may not even attempt losing weight because they think they won’t be able to kick the “junk food” habit.
No one likes to set themselves up for failure. But is there hope of getting over the sweet tooth or a preference for fatty foods by sticking to a strict regimen? New research published in this month’s issue of Obesity suggests that, yes, there is, which could also explain why people who stay on an Isagenix program long-term see their cravings lessen over time.
The randomized trial, led by a collaborative effort from researchers at Temple University, Pennington Biomedical Research Center, University of Colorado and Washington University, studied the effects of following either a low-carb or low-fat diet. At the end of the two-and-a-half-year trial, the researchers found that both groups of dieters had decreased cravings and preferences for the foods their diet restricted.
The study participants, 270 obese adult men and women, attended regular group sessions where they were coached on how to stick with their diets. They filled out questionnaires rating how often they had food cravings, for what types of foods, what foods they naturally preferred to eat, and the size of their appetite. The low-carb group had significantly reduced cravings for carbs and starches, as well as a lesser amount of times that sweets or fast foods were craved. Also, their preference for high-carb and high-sugar foods decreased. Likewise, the low-fat group experienced reduced cravings for the high-fat and low-carbs foods that were restricted in their diet.
Since the low-fat group consumed fewer calories overall than the low-carb group, it’s not surprising that the low-carb group reported being less bothered by hunger. Or, it could also have something to do with the higher amount of protein the low-carb group was eating since protein is known to keep people feeling fuller longer—we know that high-protein IsaLean Shakes work on the same principle.
The authors conclude, “Promoting the restriction of certain types of foods while dieting results in decreased cravings and preferences for the foods that are targeted for restriction.”
This study showed that men had a bigger decrease in high-fat food cravings, in addition to larger decreases in overall hunger, times of being bothered by hunger, the desire to eat in response to the sight or smell of food, and thoughts about food. Interestingly, there was a gender difference when it came to food cravings and preferences. The authors note that this has been pointed out before: obese men tend to prefer foods such as pizza and French fries more, while obese women favor foods such as cake and doughnuts.
Something else to think about, although not noted in the study results, is that part of the study design and potential reason for participants’ success is that they attended regular group sessions where they discussed their progress and continued adherence to the diets. This may point to the benefit of being involved in a group where diet and health are discussed. People might hold themselves more accountable when it comes to their diet, while the support of the group may help people stay on track to reach weight-loss goals.
So, how to best stick to a program, consistently lose pounds and eventually get to that desired target weight? Stay disciplined—eventually your stomach may learn to no longer crave for those diet-busting, high-calorie foods that are rich in fat or carbohydrates. And a little help from a network of friends (like those on Facebook) to keep you on track can go a long way.
Reference: Martin CK, Rosenbaum D, Han H et al. Change in food cravings, food preferences, and appetite during a low-carbohydrate and low-fat diet. Obesity (Silver Spring) 2011;19:1963-70. doi:10.1038/oby.2011.62

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Fish Oil May Help Older Women Strengthen Bones

Terry.Azeltine@msn.com — Fri, 28 Oct 2011 16:03:34 PDT

Posted: 26 Oct 2011 11:30 AM PDT

A new study suggests combining omega-3 supplementation with exercise for stronger bones

It's long been known that adequate intake of certain nutrients such as calcium and vitamin D, along with an active lifestyle, are important factors for promoting bone health during aging. Women are especially susceptible to the frailty, fractures and morbidity that accompany age-associated bone loss and osteoporosis. Now, before you lace up your tennis shoes for your next walk or run, or hit the weights, perhaps you should add omega-3 fatty acids from fish oil to your bone-enhancing arsenal.
In a just-published study in the journal Nutrition and Metabolism, researchers from the Urmia University in Iran, in collaboration with the University of Missouri, have evaluated the synergistic effects of six months of fish oil and aerobic exercise on biomarkers of inflammation and bone health in 79 post-menopausal women aged 58 to 78. They also determined whether fish oil and exercise alone could affect these markers implicated in bone loss.
The treatments consisted of a control group, an exercise alone group, a group that only supplemented with 1 gram of fish oil containing 180 milligrams EPA and 120 milligrams DHA, and a group that combined the fish oil supplementation with aerobic exercise consisting of walking or jogging for 25 to 30 minutes per day for three or four days a week.
After six months of intervention, the researchers found that those women in the exercise and supplement group had significantly lower biomarkers of inflammation (c-reactive protein, prostaglandin E2 and interleukin-6), and increases in their serum vitamin D, estrogen and bone mineralization compared with the control subjects. For many markers of bone health and inflammation, the supplement alone and exercise alone groups also tended to observe benefits, although less than in the combined exercise and supplement group. In addition, the researchers linked inflammation and bone mineralization, and reported a strong negative association between bone mineral density and inflammatory mediators, indicating that those individuals who increased bone health also had less inflammation.
According to the authors, “These findings clearly show that the combination of PUFA [polyunsaturated fatty acid] supplementation with aerobic exercise provides numerous benefits on bone density and inflammation over exercise alone or supplementation alone.”
Finally, the authors noted that, “These changes in inflammatory indices following long-term aerobic exercise training and N-3 PUFA [omega-3 polyunsaturated fatty acid] supplementation may contribute significantly to the inverse relationship between inflammatory markers and osteoporosis.”
So to maximize your workout and minimize age-associated bone loss, consider the following—stretch, exercise, and follow your workout with a glassful of healthy, muscle-promoting IsaLean Shake along with a packet of Ageless Essentials Daily Pack containing bone-building calcium, vitamin D, vitamin K2, and purified, potency-guaranteed fish oil!
Reference: Tartibian B et al. Long-term aerobic exercise and omega-3 supplementation modulate osteoporosis through inflammatory mechanisms in post-menopausal women: a randomized, repeated measures study. Nutrition & Metabolism 2011;8:71 doi: 10.1186/1743-7075-8-71.

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Burn Easily in the Sun? More Reason to Take Vitamin D

Terry.Azeltine@msn.com — Sat, 15 Oct 2011 13:05:41 PDT

Posted: 13 Oct 2011 09:45 AM PDT

A new study suggests that fair-skinned people cannot make enough vitamin D from the sun and might consider a supplement to maintain healthy levels

Low levels of the sunshine vitamin are common among the U.S. population, but can depend partially on skin color. Those with darker skin are more likely to have lower levels of vitamin D in comparison with those with lighter skin at the same latitude because pigmentation can naturally block UVB-induced vitamin D synthesis.
Surprisingly, however, a new study suggests that those with very pale skin may have lower levels of vitamin D even at latitudes where sunshine is plentiful. For those with pale skin, the researchers say, supplementation may be the best alternative for achieving optimal levels while avoiding the harmful rays that could contribute to skin cancer.
Researchers from the Cancer Research UK Centre at the University of Leeds, United Kingdom, tested blood concentrations of the active circulating form of vitamin D (25(OH)D) in approximately 1,200 people and found that more than half of the participants had levels lower than optimal, and that individuals with fair skin were significantly more likely to have suboptimal vitamin D levels.
The study, published in Cancer Causes and Control, suggests that sun-sensitive people such as those with pale skin, or melanoma patients, are not able to generate enough vitamin D from UVB rays to meet optimal levels while also avoiding sunburn.
“Sun-sensitive individuals did not achieve optimal levels without supplementation, which therefore should be considered for the majority of populations living in a temperate climate,” the researchers wrote.
In the study, the researchers defined optimal levels as having blood concentrations at or above 60 nmol/L (24 ng/ml), because of the association of this level with long-term health. The only individuals in the study who reached optimal levels had more than 12 hours of sun exposure over summer weekends.
Reference: Davies JR, Chang YM, Snowden H et al. The determinants of serum vitamin D levels in participants in a melanoma case-control study living in a temperate climate. Cancer Causes Control 2011;22(10):1471-82. doi: 10.1007/s10552-011-9827-3.
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Life’s Stresses Got You Down? Reach for Adaptogens

Terry.Azeltine@msn.com — Sun, 02 Oct 2011 09:11:07 PDT

Posted: 29 Sep 2011 03:52 PM PDT

Adaptogens help immunize against the harmful effects of stress.

When coping with stress and temporary bouts of fatigue, most Americans reach for that extra cup of coffee or energy shot to get through the day. Others resort to alcohol, high-calorie snacks, cigarettes, or TV and the couch for an escape. But these habits are counter-productive; they can bring on disrupted sleep, withdrawal symptoms, or weight gain that eventually worsens mental and physical performance.
There may be a better way: adaptogens.
Swedish Herbal Institute researchers Alexander Panossian and Georg Wikman examined randomized, clinical trials on extensively studied adaptogens including rhodiola (Rhodiola rosea), schizandra berry (Schisandra chinensis), and eleuthero root (Eleutherococcus senticosus). They found that these and other adaptogens not only reduce stress and fatigue, but also improve attention and focus.
According to their recently published scientific review on adaptogens published in Current Clinical Pharmacology (1), the reason these herbs are effective may be because they stimulate biochemical pathways that help mediate the harmful effects of stress on the body. Among the findings from studies the authors included in their review were the following:

Rhodiola improved levels of emotional stability, self-esteem, and attention while also reducing fatigue and insomnia.
Eleuthero root reduced feelings of fatigue and increased resistance to low-oxygen settings, such as in deep-sea diving or high altitudes.
Schizandra increased work accuracy and feelings of general well-being, and decreased feelings of sleepiness and exhaustion.

From the Greek word “adapto” meaning “to adjust,” the term adaptogen is applied to any botanical that enhances resistance to stress without the side effects of conventional stimulants. Caffeine, according to the researchers, works by “tricking” the brain to make it more alert, but depletes its energy and resources. On the other hand, adaptogens increase the work capacity of the body or brain by being “stress-protective” or “restorative”.
Stress Vaccines
One of the main questions Panossian and Wilkman sought to answer was how adaptogens work. In their paper, they propose that adaptogens may help the body adapt to stress by inducing a mild stress response in the body. Acting like a “stress vaccine” adaptogens then inoculate against future sources of stress.
In a sense, adaptogens mimic stress, creating an adaptive response in the nervous, cardiovascular, endocrine, immune and gastrointestinal systems. The authors suggest that through the regulation of stress with adaptogenic herbs, consumers may enjoy “enhanced mental and physical performance, and, possibly, increased longevity.”
Writing in a second review published in Pharmaceuticals in 2010 (2), the same authors wrote that these herbs normalize homeostasis (balance in the body) through several mechanisms akin to mild stress hormones. For example, active components of rhodiola, schisandra and eleuthero are structurally similar to catecholamines—primary regulators of stress—and other components resembling corticosteroids that help to inactivate a stress response. Fortunately, what adaptogens won’t do is impair mental function or cause addiction.
Ionix® Supreme: Adaptogen-rich Stress Tonic

Ionix Supreme is "nature's answer to stress."

Ionix Supreme, deemed “nature’s answer to stress”, is an adaptogen-rich drink designed with potent amounts of rhodiola, shisandra and eleuthero—as discussed by Panossian and Wilkman above—along with other beneficial herbs including:

Wolfberry (Lycium barbarum) acts as an adaptogen and an antioxidant for the maintenance of good health and increased mental and physical performance (3-5).
Ashwagandha (Withania somnifera) operates as an antioxidant for maintaining good health as well as stimulates liver detoxification (6). It may also support the brain (7) and immune function (8) while increasing the body’s resistance to stress (9).
Bacopa (Bacopa monnieri) acts as an antioxidant in the maintenance of brain health (10) and has been found to help maintain normal memory and cognitive function (11, 12).

With these herbal ingredients acting synergistically, drinking a shot or two of Ionix Supreme daily offers consumers an advantageous way of obtaining the protection adaptogens provide against stress. The drink can also help improve focus, attention or athletic performance.
Several recent studies also suggest that better management of psychological stress and minimizing its effects may also support more graceful aging. For example, a recent study published in August’s issue of Nature discovered that mice chronically infused with adrenaline, a hormone released by the body in reaction to stress, resulted in injured DNA (13). This study may help to explain why those individuals subjected to chronic psychological stress have shorter telomeres (14), the protective caps on chromosomes whose length is considered a biomarker of aging.
Researchers are already studying several ways of combating the ill effects of stress on cells and their telomeres, including the role of exercise. What role will adaptogens have? Adaptogens in a supplement such as Ionix Supreme could be the key to beating stress, supporting healthier aging, and increasing longevity.
References

Panossian A, Wikman G. Evidence-based efficacy of adaptogens in fatigue, and molecular mechanisms related to their stress-protective activity. Curr Clin Pharmacol 2009;4:198-219.
Panossian A, Wikman G. Effects of adaptogens on the central nervous system and the molecular mechanisms associated with their stress—protective activity. Pharmaceuticals 2010;3:188-224. doi: 10.3390/ph3010188
Amagase H, Sun B, Borek C. Lycium barbarum (goji) juice improves in vivo antioxidant biomarkers in serum of healthy adults. Nutr Res 2009;29:19-25. doi: 10.1016/j.nutres.2008.11.005
Zhang R, Kang KA, Piao MJ et al. Cytoprotective effect of the fruits of Lycium chinense Miller against oxidative stress-induced hepatotoxicity. J Ethnopharmacol 2010;130:299-306. doi: 10.1016/j.jep.2010.05.007
Amagase H, Nance DM. A randomized, double-blind, placebo-controlled, clinical study of the general effects of a standardized Lycium barbarum (Goji) Juice, GoChi. J Altern Complement Med 2008;14:403-12. doi: 10.1089/acm.2008.0004
Jeyanthi T, Subramanian P. Nephroprotective effect of Withania somnifera: a dose-dependent study. Ren Fail 2009;31:814-21. doi: 10.3109/08860220903150320
Jayaprakasam B, Padmanabhan K, Nair MG. Withanamides in Withania somnifera fruit protect PC-12 cells from beta-amyloid responsible for Alzheimer’s disease. Phytother Res 2010;24:859-63. doi: 10.1002/ptr.3033
Ziauddin M, Phansalkar N, Patki P, Diwanay S, Patwardhan B. Studies on the immunomodulatory effects of Ashwagandha. J Ethnopharmacol 1996;50:69-76.
Davis L, Kuttan G. Immunomodulatory activity of Withania somnifera. J Ethnopharmacol 2000;71:193-200. doi: 10.1016/S0378-8741(99)00206-8
Uabundit N, Wattanathorn J, Mucimapura S, Ingkaninan K. Cognitive enhancement and neuroprotective effects of Bacopa monnieri in Alzheimer’s disease model. J Ethnopharmacol 2010;127:26-31. doi: 10.1016/j.jep.2009.09.056
Morgan A, Stevens J. Does Bacopa monnieri improve memory performance in older persons? Results of a randomized, placebo-controlled, double-blind trial. J Altern Complement Med 2010;16:753-9. doi: 10.1089/acm.2009.0342
Roodenrys S, Booth D, Bulzomi S, Phipps A, Micallef C, Smoker J. Chronic effects of Brahmi (Bacopa monnieri) on human memory. Neuropsychopharmacology 2002;27:279-81.
Hara MR, Kovacs JJ, Whalen EJ, Rajagopal S, Strachan RG, et al. A stress response pathway regulates DNA damage through beta2-adrenoreceptors and beta-arrestin-1. Nature. 2011 (August online issue). doi: 10.1038/nature10368
Epel ES, Blackburn E, Lin J, Dhabhar FS, et al. Accelerated telomere shortening in response to life stress. PNAS 2004;101(49):17312-17315 doi: 10.1073/pnas.0407162101

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Antioxidants for Healthier Arteries

Terry.Azeltine@msn.com — Sun, 02 Oct 2011 09:06:36 PDT

Posted: 30 Sep 2011 03:18 PM PDT

Antioxidant combination improves arterial elasticity, according to recent study.

Among the several ingredients in Ageless Essentials with Product B are vitamin C, coenzyme Q10 (coQ10), vitamin E, and selenium. A recent study has found that this combination improves arterial elasticity when taken long term.
Arterial elasticity refers to how stiff or elastic arteries are, and more elastic means the better it is for your overall health and heart. Arteries become more rigid generally with age, hypertension or atherosclerosis.
The randomized, controlled trial (1), published in Nutrition and Metabolism, compared the effects of daily supplementation of the combination versus a placebo over six months on 70 participants who had at least two cardiovascular risk factors (hypertension, diabetes, high triglycerides, low HDL cholesterol, or smoking). After six months, the antioxidant-supplemented group showed significantly increased large and small arterial elasticity compared to placebo.
The cardiovascular benefit was also associated with better maintenance of glucose and lipid metabolism as well as blood pressure.
“We have demonstrated that combined antioxidant supplementation with vitamin C, vitamin E, coenzyme Q10 and selenium has beneficial effect on glucose and lipid metabolism, blood pressure and arterial compliance in patients with multiple cardiovascular risk factors,” the authors wrote. “The findings of the present study justify investigating the overall clinical impact of antioxidant treatment in this population,” wrote the authors.
Previous studies have found each of the nutrients deliver other benefits to the cardiovascular system and to myocardial function.
Vitamin C status is associated with vascular endothelial function, healthy blood pressure and protection against oxidative stress. In young women, higher plasma levels of vitamin C are associated with better maintenance of blood pressure and levels of C-reactive protein (CRP) (2, 3). CRP is a protein that when measured in the blood reflects the amount of swelling in the body, and high levels can get in the way of having a healthy heart.
CoQ10 plays a key role as a fat-soluble antioxidant involved in the health of myocardial tissues and their function. Supplementation not only helps the body to fight off oxidative stress, but has also shown to increase physical performance and power in athletes and non-athletes alike (4, 5). CoQ10 is also important for recycling vitamin E.
Vitamin E is associated with better cardiovascular health when combined with other antioxidants and micronutrients in the diet (6). In addition, increased consumption of polyunsaturated fats also increases the requirement for the nutrient. In a survey of vitamin E intake of approximately 10,000 American adults (7), more than 90 percent failed to meet current recommendations for vitamin E intake!
Selenium is a trace mineral with antioxidant properties because it is required for the function of selenium-dependent enzymes known as selenoproteins. Selenoprotein examples include glutathione peroxidase, a key antioxidant enzyme involved in protecting against oxidative stress, which can harm cardiovascular health. Supplementation is shown to assist in reducing oxidative stress in overweight adults (8).
Ageless Essentials Daily Pack features the following: C-Lyte, which provides 520 mg of vitamin C per day as mineral ascorbates that are easier on the stomach; Ageless Actives, providing 100 mg of coQ10 per day in a lipid-solubilized form developed by Bill Judy, Ph.D. The coQ10 is eight times (800 percent) more absorbable than typical dry powder forms; Essentials for Men or Women, providing 90 IU of vitamin E (as natural mixed tocopherols and d-alpha tocopheryl succinate) and 100 mcg of selenium per day. With complementary nutrients such as fish oil (omega-3s) and vitamin K2, Ageless Essentials Daily Pack represents a convenient strategy for better cardiovascular health
References
1. Shargorodsky M et al. Effect of long-term treatment with antioxidants (vitamin C, vitamin E, coenzyme Q10 and selenium) on arterial compliance, humoral factors and inflammatory markers in patients with multiple cardiovascular risk factors. Nutr Metab (Lond) 2010;7:55. doi: 10.1186/1743-7075-7-55
2. Block G et al. Vitamin C in plasma is inversely related to blood pressure and change in blood pressure during the previous year in young Black and White women. Nutr J 2008;7:35. doi: 10.1186/1475-2891-7-35
3. Judy WV, et al. Myocardial preservation by therapy with coenzyme Q10 during heart surgery. Clin Investig 1993;71(8 Suppl):S155-61.
4. Gokbel H, Gul I, Belviranl M, Okudan N. The effects of coenzyme Q10 supplementation on performance during repeated bouts of supramaximal exercise in sedentary men. J Strength Cond Res 2010;24:97-102.
5. Ylikoski T, Piirainen J, Hanninen O, Penttinen J. The effect of coenzyme Q10 on the exercise performance of cross-country skiers. Mol Aspects Med 1997;18 Suppl:S283-S290.
6. Jialal I and Devaraj S. Vitamin E supplementation and cardiovascular events in high-risk patients. N Engl J Med 2000;342:154-60.
7. Maras JE, Bermudez OI, Qiao N, Bakun PJ, Boody-Alter EL, Tucker KL. Intake of alpha-tocopherol is limited among US adults. J Am Diet Assoc 2004; 104 :567 –75. doi: 10.1016/j.jada.2004.01.004
8. Savory LA, kerr CJ, Whiting P, Finer N, McEneny J, Ashton T. Selenium supplementation and exercise: effect on oxidative stress in overweight adults. Obesity 2011 May 19. [Epub ahead of print]. doi:10.1038/oby.2011.83
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Vitamin K2: Healthier Arteries, Stronger Bones

Terry.Azeltine@msn.com — Sun, 18 Sep 2011 10:06:43 PDT

Posted: 17 Sep 2011 11:11 AM PDT

Vitamin K2 keeps arteries functioning youthfully.

It was a 16th century English physician by the name of Thomas Sydenham who is credited with the saying, “A man is as old as his arteries.” Five centuries later and the adage still rings true. The age of our arteries, or our vascular age, can be a significant factor in determining how long we will live. However, our scientific understanding of vascular age has grown substantially compared to five centuries ago. Cardiologists are now able to better determine the health of our blood vessels through measurements of blood pressure, cholesterol, triglycerides, and arterial calcification.
Arterial calcification is the deposition of calcium within the arterial linings, literally turning arteries into bone. The deposits result in a thickening of the arterial walls, which robs arteries of flexibility and elasticity. They also contribute to the accumulation of arterial plaque structure with fatty deposits and cholesterol, which culminates in fatty streaks and eventually, atherosclerosis. Recently, cardiologists have also discovered that arterial calcification is often accompanied by the weakening of bones. The relationship between the calcification of blood vessels and the decalcification of bones has its roots in a protein known as Matrix Gla (MGP).
MGP is a vitamin K-dependent protein that acts as an arterial calcification inhibitor and could play a critical role for improving vascular age (1). This protein binds calcium ions, thereby promoting their proper biological activity. Vitamin K is necessary for MGP to function because it acts as a cofactor for the γ-carboxylation of the protein. Notably, the drug warfarin being a vitamin K antagonist is long known to cause arterial calcification in rats (1,2). In contrast, a diet high in vitamin K inhibited arterial calcification and helped preserve arterial elasticity in warfarin-treated rats (1,2). However, caution should be exercised before combining vitamin K with warfarin and patients should always discuss supplementation or changes of diet with their doctors.
K1 versus K2
Vitamin K is a fat-soluble vitamin existing in two naturally occurring forms: vitamin K1 (phylloquinone) and vitamin K2 (menaquinone). Vitamin K1 is synthesized in plants and bacteria and can be converted into vitamin K2. A third, synthetic form also exists and is known as vitamin K3 (menadione), which can be toxic unlike the natural forms. The primary function of vitamin K is in a complex pathway involved in blood coagulation. Specifically, vitamin K is required for an enzyme that catalyzes the carboxylation of glutamic acid, forming γ-carboxyglutamate, a necessary amino acid for calcium binding and initiation of the blood clotting process. Other functions include bone mineralization and cellular growth.
Recent research suggests vitamin K1 and K2 should be appreciated as separate nutrients. Unlike vitamin K1, vitamin K2 is needed to activate osteocalcin, a bone-building hormone that is responsible for the clearance of calcium from arteries and shuttling it for the purposes of bone mineralization (3,6), thereby removing excess calcium otherwise available for arterial calcification.Unfortunately, a substantial portion of Americans are obtaining a suboptimal amount of vitamin K, which is inadequate to meet the essential γ-carboxylation required for vitamin K-dependent functions (3-5, 7). Furthermore, low plasma levels of K2 do not maximize carboxylation of osteocalcin (3,6). In one prospective, population-based study, scientists examined the relationship between dietary intake of vitamin K1 and vitamin K2 and its relationship to arterial calcification (6). The study found a strong inverse relationship between vitamin K2 and arterial calcification, while vitamin K1 was not related to any specific outcome. These conclusions remained after adjusting for BMI, smoking, education, diabetes, alcohol intake, and dietary factors. Overall, the results suggest that high vitamin K2 intake may be an important strategy for helping to preserve arteries elasticity.
The RDA for vitamin K is 120 μg/day and 90 μg/day for adult men and women, respectively. Good dietary sources of vitamin K1 include green leafy vegetables (kale, spinach, collards, and lettuce) and some vegetable oils. In contrast, dietary sources of vitamin K2 are mainly eggs, meat, and cheese. In fact, it is hypothesized that vitamin K2 may account for the reduced arterial calcification in France and Mediterranean countries because of their high cheese consumption.
Like other fat-soluble vitamins, a severe deficiency of vitamin K in westernized societies usually only occurs in individuals with genetic malabsorption syndromes (with the one exception being individuals who are on anti-coagulants such as coumadin). However, one study reported that only 17 percent and 27 percent of men and women in Ireland met the current RDA goals (5), while an evaluation of vitamin K intake in America suggested that the average intake was below the RDA.
Daily supplementation with vitamin K2 offers a convenient way of obtaining the protective benefits of this critical nutrient. Ageless Essentials Daily Pack provides a total of 80 μg/day of vitamin K2 and is divided into two doses, one taken in the morning and one in the evening. The product also combines the vitamin with other complementary nutrients for cardiovascular and bone health (calcium and vitamin D). Along with proper diet and exercise, the combination represents a powerful strategy for supporting stronger bones while keeping arteries more flexible, elastic, and youthful.
After all, we’re only as old as our arteries.
References

Shea MK et al. Vitamin K supplementation and progression of coronary artery calcium in older men and women. Am J Clin Nutr 2009;89:1799-807.
Price PA et al. Warfarin causes rapid calcification of the elastic lamellae in rat arteries and heart valves. Arterioscler Throm Vasc Biol 1998;18:1400-7.
Booth SL. Roles for vitamin K beyond coagulation. Annu Rev Nutr 209;29:89-110.
Booth SL, Pennington JA, Sadowski JA. Food sources and dietary intakes of vitamin K-1 (phylloquinone) in the American diet: data from the FDA Total Diet Study. J Am Diet Assoc 1996;96:149-54.
Duggan P et al. Phylloquinone (vitamin K1) intakes and food sources in 18-64-year-old Irish adults. Br J Nutr 2004;92:151-8.
Geleijnse JM et al. Dietary Intake of Menaquinone is associated with a Reduced risk of coronary heart disease: The Rotterdam Study. J Nutr 2004;234:3100-05.
McCann JC, Ames BN. Vitamin K, an example of triage theory: is micronutrient inadequacy linked to diseases of aging? Am J Clin Nutr 2009;90:889-907.

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The Isagenix Lifestyle for Ultimate Telomere Health

Terry.Azeltine@msn.com — Sun, 11 Sep 2011 12:46:11 PDT

Posted: 06 Sep 2011 12:25 PM PDT

New Ageless Essentials with Product B is advanced support for telomere health.

The wait is over.
Nearly a year ago, we reported on the teaming up of Isagenix Founder and Master Formulator John Andrews and molecular biologist Bill Andrews, Ph.D. The two had just announced a strategic partnership wherein they would begin seeking out natural, safe compounds to create a revolutionary product that could help “turn back the clock” on aging.
The focus of their research would be telomerase, the enzyme that maintains telomeres, or the protective caps of chromosomes that shorten with age. Telomere length was already starting to become an exciting new biomarker of aging.
Over the next few months, Anderson and Dr. Andrews worked to verify the activity of a number of natural compounds and their ability to assist in the maintenance of telomere health. Then, within a year’s time, Anderson and Dr. Andrews had fantastic news: (1) ”hits,” or discovery of natural compounds with potential of supporting telomere health; and (2) a new product, Product B™ Antioxidants plus Telomere Support, which has garnered national media attention!
Telomere Health Lifestyle
As the months have passed, we’ve also highlighted several recent studies and scientific reviews on how diet and lifestyle can influence telomere length. As the science clearly points out, factors that contribute to oxidative stress play a key role in the speeding up of telomere shortening.
The major contributors of oxidative stress are exposure to environmental toxins, being overweight or obese, being overstressed, and eating a poor diet. To review, major strategies addressed previously for reducing oxidative stress and supporting the health of telomeres include:

Exercising regularly
Maintaining a healthy weight
Eating more nutrient-dense, reduced-calorie foods
Meeting daily requirements for vitamins and minerals (especially antioxidant vitamins E and C, the B vitamins like B12, and the hormone-like vitamin D)
Consuming sufficient amounts of long-chain omega-3 fatty acids (DHA and EPA)
Limiting exposure to environmental toxins, especially from smoking or excessive drinking
Reducing or managing stress through exercise and meditation
Practicing healthy sleep habits
Encouraging detoxification and reducing oxidative stress through reduced calories and supplementation on Cleanse Days and Shake Days
Supplementation with specific bioactives that guard against oxidative stress or that promote the efficient activity of antioxidant enzymes (such as coQ10, green tea, milk thistle, curcumin, and resveratrol)
Consuming quality protein (such as whey) containing higher concentration of amino acids that help maintain glutathione levels

Many of these strategies are enhanced with regular use of an Isagenix system and the company’s Pillars of Health products:

IsaLean Shake
Ionix Supreme
Cleanse for Life
Ageless Essentials Daily Pack

The products used on Shake Days and Cleanse Days, respectively, help people maintain a healthy weight, achieve optimal nutrition, and limit their exposure to oxidative stress.
Introducing Product B
Isagenix introduced Product B at the 2011 “Ignite Your Future: Stay Young Forever” Celebration on Aug. 14, 2011. The billion-dollar breakthrough product, importantly, is now included as part of Ageless Essentials Daily Pack. Ageless Essentials with Product B is a matter of ultimate convenience for telomere protection based on the latest research and technology. The individually wrapped A.M. and P.M. packets contains each of the following:

Product B Antioxidants plus Telomere Support combines the cutting-edge science in the field of telomere support with oxidative stress-fighting antioxidants that help you regain and maintain a more youthful vitality. A complex blend botanicals and vitamins that goes to work targeting the sources of aging and protecting your telomeres, and you, from harmful free radicals that speed up aging and contribute to poor health.
Essentials for Men or Women, now featuring advanced disintegration and absorption technologies, provides the body with a steady stream of essential vitamins and minerals at timed intervals throughout the day.
Ageless Actives provides coQ10 (ubiquinone) in a tri-lipid solution that is 800 percent more absorbable than other forms. It also contains 1,000 IU per serving of vitamin D3, which enhances the body’s absorption of calcium and maintains a strong cardiovascular system, and 250 mg of resveratrol per serving, which is equivalent to more than 100 glasses of red wine. Red grape and pomegranate extracts also help protect cells from the effects of free radicals.
IsaOmega Supreme comes in a fresh, lemony taste and provides fish oil with a high concentration of DHA and EPA long-chain omega-3 fatty acids (1,200 mg) to meet recommendations for cardiovascular health. Each batch of IsaOmega Supreme is third-party tested for top-quality purity, meaning free of heavy metals, PCBs and dioxins.
C-Lyte provides vitamin C as a variety of mineral ascorbates to be gentle on the stomach and provide the extra antioxidant protection the body needs in an environment of constant bombardment from oxidative stressors.

Maintaining healthy telomeres has never before been so easy. Forget about having to have multiple bottles to meet nutritional requirements and address the underlying mechanisms of aging. Ageless Essentials with Product B supplies a scientifically backed combination of vitamins, minerals, and bioactives the body needs to support healthy telomeres.
The product also fits directly in to almost anyone’s lifestyle of Cleanse Days and Shake Days as part of major Isagenix Paks for weight management, total health and longevity.
Welcome to a new era of ultimate telomere protection and youthful aging.

Lose Stubborn Fat with More Whey from Dairy

Terry.Azeltine@msn.com — Sun, 04 Sep 2011 10:08:58 PDT

Posted: 01 Sep 2011 05:16 PM PDT

Eating more protein from dairy may boost fat loss, especially around the belly, according to new study.

Does the phrase “weight-loss plateau” ring a bell? If you’ve ever embarked on a weight-loss journey, it more than likely does. And now there’s good news for you—results from a just-published study show that losing more belly fat and gaining more muscle is easier by eating more protein from dairy. The researchers credit the results to the whey protein fraction of the milk.
The study, published in the September issue of the Journal of Nutrition, followed 90 overweight or obese women (aged 19-45) for 16 weeks as they followed a weight-loss program—500 calories lower than normal. The women were randomly assigned to one of three groups: the first group consumed 0 to 1 servings of dairy each day (low dairy and adequate protein), the second group consumed 3 to 4 servings of dairy each day (medium dairy and adequate protein), and the third group consumed 6 to 7 servings of dairy each day (high dairy and high protein). One serving of dairy was equal to about 1 cup of milk or about 1.5 ounces of cheese.
The diets were designed so that the women consuming the most dairy were eating two times more protein and lower carbohydrates than the other two groups, and twice the amount of dairy than the medium dairy group. All women engaged in an exercise program that included aerobic exercise five times a week and resistance training two times.
At the end of 16 weeks the women in the high dairy and high protein group lost significantly more fat, particularly belly fat, and gained more muscle mass than the women in the other two groups. All the women in the study lost weight, but lead author of the study and graduate student in the Department of Kinesiology at McMaster University, Andrea Josse, points out, “One hundred percent of the weight lost in the higher-protein, high-dairy group was fat. And the participants gained muscle mass, which is a major change in body composition.”
Body composition after weight loss is important because as with any weight-loss program, fat is lost, but at the same time so is muscle, which may help explain the “plateau” effect. Not only that, but muscle plays a crucial role in regulating levels of glucose and fats in the blood, which means losing muscle could have negative effects on long-term metabolic health.
Also detrimental to preserving metabolic health is belly fat, or visceral fat. “Fat in the abdomen is thought to be especially bad for cardiovascular and metabolic health, and it seems—according to what we found in this study—increasing calcium and protein in the diet may help to further promote loss of fat from the worst storage area in the body,” Josse said.
The authors suggest the increased fat loss seen with higher consumption of dairy is “likely related to other bioactive components such as the protein fraction [whey] rich in branched-chain amino acids (leucine, isoleucine, and valine).”
Reference
Josse AR, Atkinson SA, Tarnopolsky MA, Phillips SM. Increased Consumption of Dairy Foods and Protein during Diet- and Exercise-Induced Weight Loss Promotes Fat Mass Loss and Lean Mass Gain in Overweight and Obese Premenopausal Women. J Nutr 2011;141:1626-34. doi: 10.3945/jn.111.141028
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Whey in Large Doses After Exercise Brings Bigger Gains in Muscle and Strength

Terry.Azeltine@msn.com — Sun, 04 Sep 2011 10:04:26 PDT

Posted: 02 Sep 2011 08:00 AM PDT

Whey protein in higher doses after training is better for muscle and strength gains, two studies suggest.

Athletes who consume large doses of whey protein or a leucine-enriched drink directly after training increase their gains in muscle and strength, according to two independent studies published in the American Journal of Clinical Nutrition.
One study from McMaster University in Canada (1) found that recreational athletes who consume 25 grams of whey protein after exercise increased muscle protein synthesis more than when smaller doses are given over time. Another study, performed by U.S. Army researchers and colleagues from other universities (2), found that an essential amino acid drink supplement containing higher concentrations of leucine increases protein synthesis up to 33 percent more than one with lower amounts of leucine.
The McMaster University researchers compared the effects of consuming 25 grams of whey protein versus 10 smaller doses every 20 minutes over 200 minutes in eight athletic men immediately after resistance training. They found that whey protein in the large single dose delivered a greater increase in plasma amino acids (including leucine) to trigger muscle protein synthesis compared with protein in smaller doses over time.
The US Army researchers and their colleagues evaluated muscle protein synthesis and whole body protein metabolism in eight adults who cycled for 60 minutes. Immediately after the workout, the subjects consumed a drink containing 10 grams of essential amino acids; the first drink contained 1.87 grams leucine and the second contained 3.5 grams leucine. The researchers observed 33 percent more protein synthesis in the subjects who consumed more leucine.
“These findings suggest that increasing the concentration of leucine in an [essential amino acids] supplement consumed during steady state exercise elicits a greater [muscle protein synthesis] response during recovery,” the researchers wrote.
Earlier studies have similarly noted the muscle-building potential of whey protein, leucine and other branched chain amino acids. Whey protein is a protein source with a higher concentration of branched-chain amino acids including leucine.
Both studies suggest that athletes should take advantage of consuming single large doses of high-quality whey protein after training. This is easily achieved by consuming 1½ scoops of IsaLean Shake mixed with 1 scoop of IsaPro (containing about 4 grams of leucine). The result could mean more quality gains after each workout, stronger muscles and a greater competitive edge.
References
1. Pasiakos SM et al. Leucine-enriched essential amino acid supplementation during moderate steady state exercise enhances postexercise muscle protein. Am J Clin Nutr 2011;94:809-818. doi: 10.3945/ajcn.111.017061
2. West, DW et al. Rapid aminoacidemia enhances myofibrillar protein synthesis and anabolic intramuscular signalingresponses after resistance exercise. Am J Clin Nutr 2011;94:795-803. doi: 10.3945/ajcn.111.013722
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Eating Fewer Calories on Isagenix for a Longer Life

Terry.Azeltine@msn.com — Sat, 27 Aug 2011 09:54:32 PDT

Posted: 26 Aug 2011 10:26 PM PDT

Fewer calories on an Isagenix system could mean a longer life.

Followers of an Isagenix system complete with Shake Days and Cleanse Days can look forward to possibilities of lifelong health—because of reduced bodyweight, muscle maintenance, and optimal nutrition—and perhaps even a longer life from consistently eating fewer calories.
Since the 1930s when Cornell University researcher Clive McCay reported that a reduction in calories (without undernutrition) extended mammalian lifespan, hundreds of subsequent studies conducted found it could extend lifespan and delay the onset of age-related outcomes in a variety of species.
Research over the past 80 years brings hope that the same results could transfer to humans, although, calorie restriction (CR) studies in humans are lacking. However, there are already exciting results suggesting that CR very well may protect health and extend life.
Okinawa
One group of humans that have provided evidence from a “natural experiment” in long-term CR is the older generation of Okinawans from Japan. Because of poverty when they were younger, these Okinawans were so deprived of calories that it stunted their growth, but, even so, their quality of diet was adequate enough to keep them free of nutritional deficiencies and poor health that afflict most of the third world.
To this day, there are more people who have lived over 100 years of age in Okinawa than in any other part of the world—leading researchers to believe this may be evidence that CR may provide protection from the effects of aging in humans.
Biosphere 2
There are relatively few actual studies on long-term CR in humans. A famous one that was accidental was as part of an entirely different experiment, Biosphere 2. Eight volunteers were sealed inside an enclosed three-acre space meant to be an "ecological mini-world". They ran into problems when their food supply unexpectedly dwindled to meager portions.
Coincidentally, the crew's physician, Roy Walford, M.D., was one of the pioneers in CR, so he convinced his fellow biospherians to embark on their own CR experiment. Their results showed that CR decreased BMI, blood pressure, fasting blood glucose, insulin, and cholesterol.
Calorie Restriction Society
Another source for information on humans restricting their food intake is from the Calorie Restriction Society (CRS) whose members adhere to a CR regimen because of evidence from animal studies.
Data collected show the CRS members exhibited similar results as the subjects in Biosphere 2. Of particular notice was their low blood pressure and reduced incidence of chronic oxidative stress compared to similarly aged individuals.
CALERIE
The growing interest in the effects of CR in humans has led to a multi-collaborative research program, CALERIE (Comprehensive Assessment of Long-Term Effects of Reducing Calorie Intake). This program is a joint effort of the National Institute on Aging along with several other research centers (Tufts University, Pennington Biomedical Research Center, Washington University, and Duke University) whose goal is to research the effects of long-term CR in humans.
Phase I of CALERIE consisted of three pilot studies that examined healthy, overweight men and/or women (BMI 25-29.9 kg/m) and restricted their calories by varying degrees for six or 12 months.
Results showed that CR led to decreases in body weight, fat mass, core body temperature, visceral and subcutaneous fat mass. The study also showed decreased fasting glucose and improved insulin sensitivity.
Future studies will target younger individuals with lower BMI (not overweight or obese).
Although the research on CR in humans is still in its infancy, what has been found so far suggests similar life-extending benefits as previously demonstrated in animal studies.
References
Holloszy JO, Fontana L. Caloric restriction in humans. Exp Gerontol 2007;42:709-12. doi: 10.1016/j.exger.2007.03.009
Chan YC, et al. Dietary, anthropometric, hematological and biochemical assessment of the nutritional status of centenarians and elderly people in Okinawa, Japan. J Am Coll Nutr 1997;16:229–235.
Heilbronn LK, et al. Effect of 6-month calorie restriction on biomarkers of longevity, metabolic adaptation, and oxidative stress in overweight individuals: a randomized controlled trial. JAMA 2006;295:1539–1548.
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Questions about Just-Launched Product B

Terry.Azeltine@msn.com — Fri, 19 Aug 2011 13:01:17 PDT

Posted: 15 Aug 2011 04:15 PM PDT

Isagenix launched Product B on August 14, 2011

If you happened to miss our 2011 “Ignite Your Future: Stay Young Forever” Celebration in San Diego, then you missed an exciting new product being formally launched—Product B™ with Antioxidants and Telomere Support. Not to worry though, because we took good notes as Isagenix Master Formulator and Founder John Anderson, along with Bill Andrews, Ph.D., and other premier telomere scientists, released the ground-breaking product. The result of pain-staking efforts and on the cutting-edge of science, Product B offers telomere support and the benefits of antioxidants so you can live a healthier, more vibrant life. We know questions are flooding everyone’s mind so we put together this information gathered from the Product B launch and question-and-answer session on Aug. 14-15, 2011.
What is Product B and why do I need it?
Product B is an advanced dietary supplement that is designed to support longevity and healthy aging. Product B works directly within the body’s cells to combat oxidative stress caused by an overabundance of free radicals and to support telomeres, critical guardians of our DNA. Keeping telomeres healthy and long is important because their shortening is a key biomarker of the aging process.
In our modern world, unfortunately, most of us suffer from greater oxidative stress due to being overweight, malnourished, and overstressed. Greater oxidative stress leads to an increased rate of telomere shortening. Product B works to reduce the harmful effects oxidative stress has on telomere length.
Besides telomere protection, are there any other benefits?
Yes! In addition to providing telomere support, Product B was developed to improve overall health and well-being. Plenty of people have already been taking Product B and are experiencing great results. Some testimonials include:

Enhanced energy and stamina
Improved quality of sleep
Faster recovery after exercise
Better memory
Mental acuity

How soon can these benefits from Product B be seen?
The results will vary, but anecdotal data suggests improvement within a few days to a few weeks.
What exactly is in Product B?
The formula for Product B is complex and involves more than 26 ingredients. It’s made from a proprietary and innovative blend of safe, well-established ingredients, including botanicals that have been used safely for centuries.
Who should take Product B?
Product B should be taken by anybody who desires to be healthy well into their old age.
At what age should one start taking Product B?
While we believe that Product B would be beneficial for all ages, it is not intended for those under the age of 18.
What is the ideal dosage?
We recommend two capsules twice daily—two in the morning and two in the evening.
Should I take them with a food/shake? Can I take them on Cleanse days?
You can take Product B on an empty stomach or with food. Product B can be taken with shakes, water, Cleanse for Life, or other food.
What’s the best way to store Product B?
Like most supplements we recommend that you store Product B in a cool, dark and dry place like in a cabinet or the refrigerator.
Are there any side effects reported?
As is the case with any dietary supplement, some people may have side effects such as allergies. Any food or supplement can cause an allergic reaction if you are allergic to an ingredient in the product. If an allergy occurs, discontinue taking the product immediately.
Can pregnant and nursing moms use Product B?
We do not recommend taking any herbal supplements during pregnancy or nursing because of lack of safety documentation in these populations. Please consult your physician if you intend to take any herbal supplements.
How safe is it to take Product B after surgery?
We do not recommend taking any herbal supplements pre or post-surgery because of possible natural blood-thinning effects. Please consult your physician if you intend to take any herbal supplements.
Are there any contradictions with Product B and Blood Thinners? Immunosuppressants? Chemotherapy?
If you are on any medication or have any medical condition, consult your physician before using Product B or any other dietary supplement.
There is talk that a telomerase activator causes cancer in humans. Will this happen with Product B?
For a nutraceutical like Product B, the answer is definitely not. Telomeres have been researched and published in medical peer-reviewed journals for many years, and no study has shown that telomerase activation causes cancer.
The public perception that telomerase activation might cause cancer stems from some scientists’ speculations in the early years of telomere research.
What’s the best way to use the Isagenix system to enhance the effectiveness of Product B?
We believe Product B will provide optimal results when combined with the other Pillars of Health: IsaLean Shake, Ionix Supreme, Ageless Essentials Daily Pack, and Cleanse for Life. These “Pillars”, when used together, can help reduce oxidative stress, support nutritional needs, cleanse the body, and ensure the required balance of carbohydrates, protein, and fats.
Where can I find more scientific information on Product B?
We have a library of information here on this blog where you can “search” for any term that goes along with Product B (i.e. telomere, oxidative stress, Product B), or at stayyoung.info. We also continue to gather more scientific evidence for the benefits of Product B and its components for customers and health professionals.
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