https://onlinelibrary.wiley.com/journal/10974644?af=R Table of Contents for Journal of Cellular Biochemistry. List of articles from both the latest and EarlyView issues. en-US wileyonlinelibrary@wiley.com (Wiley Online Library) Sat, 11 Apr 2026 07:06:31 +0000 Sat, 11 Apr 2026 07:06:31 +0000 Atypon® Literatum™ https://validator.w3.org/feed/docs/rss2.html 10080 Wiley: Journal of Cellular Biochemistry: Table of Contents Wiley Journal of Cellular Biochemistry https://onlinelibrary.wiley.com/pb-assets/journal-banners/10974644.jpg https://onlinelibrary.wiley.com/journal/10974644?af=R https://onlinelibrary.wiley.com/doi/10.1002/jcb.70088?af=R Thu, 09 Apr 2026 03:16:13 -0700 2026-04-09T03:16:13-07:00 Wiley: Journal of Cellular Biochemistry: Table of Contents Wed, 01 Apr 2026 00:00:00 -0700 Wed, 01 Apr 2026 00:00:00 -0700 10.1002/jcb.70088 Journal of Cellular Biochemistry, Volume 127, Issue 4, April 2026. ISSUE INFORMATION Issue Information 10.1002/jcb.70088 Journal of Cellular Biochemistry 10.1002/jcb.70088 https://onlinelibrary.wiley.com/doi/10.1002/jcb.70088?af=R ISSUE INFORMATION 127 4 https://onlinelibrary.wiley.com/doi/10.1002/jcb.70089?af=R Thu, 09 Apr 2026 03:12:17 -0700 2026-04-09T03:12:17-07:00 Wiley: Journal of Cellular Biochemistry: Table of Contents Wed, 01 Apr 2026 00:00:00 -0700 Wed, 01 Apr 2026 00:00:00 -0700 10.1002/jcb.70089 Journal of Cellular Biochemistry, Volume 127, Issue 4, April 2026. ABSTRACT It has been suggested that orexin‐A (OXA) exerts neuroprotective and anti‐inflammatory effects in the nervous system, while there is limited understanding of the role of OXA in cortical astrocytes under inflammation. This study was designed to investigate whether OXA could inhibit astrocyte migration induced by lipopolysaccharide (LPS) treatment and whether this action of OXA is mediated by activation of orexin 1 receptor (OX1R) in cultured mouse cortical astrocytes. OXA and OX1R were expressed in glial fibrillary acidic protein (GFAP)‐positive cultured mouse astrocytes, and their expression was significantly increased by lipopolysaccharide (LPS) treatment. In addition, treatment of LPS induced significant increases in not only astrocyte migration but also phosphorylation of K + ‐Cl‐ cotransporter 2 (KCC2), ERK, and p38 MAPK, and these increases were inhibited by OXA treatment. This inhibitory effect of OXA was restored by treatment of the OX1R antagonist, SB334867. Furthermore, OXA treatment increased GABA immunoreactivity in LPS‐treated cultured astrocytes and restored the expression of the GABA transporters GAT1 and GAT3 to levels comparable to those of the control group. This effect was abolished by SB334867 treatment. Collectively, these results suggest that OXA inhibits LPS‐induced abnormal astrocyte migration via direct activation of orexin 1 receptor and that this inhibitory effect may be related to the modulation of intracellular GABA levels and GAT expression as well as dephosphorylation of KCC2, ERK, and p38 MAPK. <h2>ABSTRACT</h2> <p>It has been suggested that orexin-A (OXA) exerts neuroprotective and anti-inflammatory effects in the nervous system, while there is limited understanding of the role of OXA in cortical astrocytes under inflammation. This study was designed to investigate whether OXA could inhibit astrocyte migration induced by lipopolysaccharide (LPS) treatment and whether this action of OXA is mediated by activation of orexin 1 receptor (OX1R) in cultured mouse cortical astrocytes. OXA and OX1R were expressed in glial fibrillary acidic protein (GFAP)-positive cultured mouse astrocytes, and their expression was significantly increased by lipopolysaccharide (LPS) treatment. In addition, treatment of LPS induced significant increases in not only astrocyte migration but also phosphorylation of K + -Cl- cotransporter 2 (KCC2), ERK, and p38 MAPK, and these increases were inhibited by OXA treatment. This inhibitory effect of OXA was restored by treatment of the OX1R antagonist, SB334867. Furthermore, OXA treatment increased GABA immunoreactivity in LPS-treated cultured astrocytes and restored the expression of the GABA transporters GAT1 and GAT3 to levels comparable to those of the control group. This effect was abolished by SB334867 treatment. Collectively, these results suggest that OXA inhibits LPS-induced abnormal astrocyte migration via direct activation of orexin 1 receptor and that this inhibitory effect may be related to the modulation of intracellular GABA levels and GAT expression as well as dephosphorylation of KCC2, ERK, and p38 MAPK.</p> Hyunjin Shin, Sheu‐Ran Choi, Dong‐Wook Kang, Hyeryeong Lee, Jaehong Park, Miae Lee, Miok Bae, Yeonhee Ryu, Suk‐Yun Kang, Chang Woo Chae, Hyun‐Woo Kim RESEARCH ARTICLE Orexin‐A Inhibits Lipopolysaccharide‐Induced Cell Migration in Cultured Mouse Astrocytes via Activation of Orexin 1 Receptor: Involvement of GABA Signaling 10.1002/jcb.70089 Journal of Cellular Biochemistry 10.1002/jcb.70089 https://onlinelibrary.wiley.com/doi/10.1002/jcb.70089?af=R RESEARCH ARTICLE 127 4 https://onlinelibrary.wiley.com/doi/10.1002/jcb.11181?af=R Wed, 10 Jan 2024 03:29:37 -0800 2024-01-10T03:29:37-08:00 Wiley: Journal of Cellular Biochemistry: Table of Contents 10.1002/jcb.11181 Journal of Cellular Biochemistry, Accepted Article. Oleg Dr Tkachenko, Oleg Dr Tkachenko Doctor Aeronautical Enginner, Carlos Dr del Pino, Maritina Dr Sevilla-García, Francisco Prof. Esteban-Ortega ARRHYTHMIA ROUNDS Test title 10.1002/jcb.11181 Journal of Cellular Biochemistry 10.1002/jcb.11181 https://onlinelibrary.wiley.com/doi/10.1002/jcb.11181?af=R ARRHYTHMIA ROUNDS