Kumpulan Jurnal-jurnal Farmasi

FORMULASI EMULSI GANDA VIRGIN COCONUT OIL (VCO) DENGAN EMULGATOR SPAN 80 DAN TWEEN 60

2011-11-17T08:28:00.000-08:00

Image via WikipediaFORMULASI EMULSI GANDA VIRGIN COCONUT OIL (VCO) DENGAN EMULGATOR SPAN 80 DAN TWEEN 60
Yandi Syukri*, Siti Zahliyatu, Maulia Ulfa
Laboratorium Teknologi Farmasi Jurusan Farmasi FMIPA
Universitas Islam Indonesia
*e-mail: yandisyukri@fmipa.uii.ac.id
ABSTRACT
Virgin Cocunut Oil (VCO) is a pure coconut oil, it has many advantages in health. It has
been circulated in market with unpleasant taste. Therefor, an innovation to find an acceptable
formula by consumer should be carried out. The aimed of this research is to find out the
influence of mix emulsifier toward physical stability of emulsion. Multiple emulsions w/o/w
were made by mix Span 80 with variation concentration 20%, 15%, 10%, and Tween 80. In order
to know the physical stability of emulsion w/o/w should be carried out viscosity test, separation in
room temperature, separation at 40ºC, separation due to centrifugation, creaming volume,
paticle size, homogenity for 4 weeks storage, and respondent survey with 20 person. The test
result for 3 formulation emulsion for 4 weeks storage showed that formulation are not
homogeneous, but arter the formulas were shaken, it become homogeneous. In various
concentration of Span 80, the longer preperations were storage the higher volume sedimentation
and viscosity. Moreover, the longer preparations were storage, creaming volume and particle size
decrease. Emulsifier combination between Span 80 with variation concentration 20%, 15%, 10%,
and tween 60 in multiple emulsion w/o/w influenced physical stability multiple emulsi w/o/w.
Moreover, this formulation also would be pleasant by consumen.
Keywords: Multiple emulsion w/o/w, Span 80, Tween 60, Virgin Coconut Oil

http://journal.uii.ac.id/index.php/JIF/article/viewFile/467/378

PENGARUH TEKNIK POLIMERISASI EMULSI TERHADAP UKURAN PARTIKEL KOPOLI(STIRENA/BUTIL AKRILAT/METIL METAKRILAT)

2011-11-17T08:25:00.000-08:00

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PENGARUH TEKNIK POLIMERISASI EMULSI TERHADAP UKURAN PARTIKEL KOPOLI(STIRENA/BUTIL AKRILAT/METIL METAKRILAT)

Influence of Emulsion Polymerization Techniques to Particle Size of Copoly(styrene/butyl acrylate/methyl methacrylate)

Emil Budianto¹, Noverra Mardhatillah Nizardo¹, & Tresye Utari ¹

1. Departemen Kimia, Fakultas MIPA, Universitas Indonesia, 16424, Indonesia

Abstract

In the majority of applications, particle size and particle size distribution are highly significant factors that determine the properties of a polymer dispersion, such as its flow behavior or its stability. For example, a coating material with small particle size will give smooth coating result, good adhesive strength, good water resistance and latex stability. This article describes influence of various emulsion polymerization techniques to particle size of copoly(styrene/butyl acrylate/methyl methacrylate) with mix surfactant SDBS linear chain and nonyl fenol (EO₁₀₎and initiator ammonium persulphate. DSC data, solid content and IR spectrum showed that copoly(styrene/butyl acrylate/methyl methacrylate) was produced. Batch emulsion polymerization technique gave the highest particle size i.e. 615 nm and also the highest % conversion of monomer i.e. 97%. The more concentration of monomer was seeded to initial charge gave greater particle size and greater poly dispersity index.

keywords: copolymerization, emulsion polymerization, particle size, polymerization, surfactant

Abstrak

Ukuran partikel merupakan salah satu faktor yang menentukan sifat polimer emulsi. Untuk aplikasi coating, dibutuhkan polimer emulsi dengan ukuran partikel yang kecil agar diperoleh hasil coating yang halus, kekuatan adhesi dan ketahanan terhadap air yang baik, serta kestabilan yang cukup lama. Penelitian ini bertujuan melihat pengaruh beberapa teknik polimerisasi emulsi terhadap ukuran partikel kopoli(stirena/butil akrilat/metil metakrilat) dengan menggunakan kombinasi surfaktan natrium dodesil benzena sulfonat rantai lurus dan nonil fenol (EO₁₀) serta inisiator ammonium persulfat. Hasil pengukuran DSC, solid content, dan IR menunjukkan bahwa terbentuk kopoli(stirena/butil akrilat/metil metakrilat). Teknik batch menghasilkan polimer emulsi dengan ukuran partikel terbesar yaitu sebesar 615 nm dengan persen konversi monomer juga terbesar yaitu 97%. Semakin besar persen seeding monomer dan inisiator yang ditambahkan ke dalam initial charge cenderung menghasilkan ukuran partikel yang lebih besar dan distribusi ukuran partikel semakin polimodal.

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List of journal with Cefotaxime keyword

2011-11-17T08:13:00.000-08:00

Image via WikipediaPhenotypic and molecular characterization of selected ESBL pathogens
Author: O.S.Ayshaa, R.Dhamotharanb, Mumtaj peermohammed c Journal: Journal of Pharmacy Research Year: 2011 Vol: 4 Issue: 2 Pages/record No.: 537-539

Formulation and Evaluation of Cefotaxime Sodium Microcapsules
Author: K.Shekhar*, M.Naga Madhu, B.Bindu Madhavi, G.Arjun, B.Pradeep, David Banji. Journal: Journal of Pharmacy Research Year: 2011 Vol: 4 Issue: 2 Pages/record No.: 317-322

Preparation and biodistribution studies of 99mTc-cefotaxime as another infection imaging agent
Author: Seyedeh Fatemeh Mirshojaei ; Mostafa Gandomkar ; Reza Najafi ; Mohamad Hosein Talebi ; Mohamad Mazidi Journal: Iranian Journal of Nuclear Medicine Year: 2010 Vol: 18 Issue: Suppl 1 Pages/record No.: 154

Development and validation of RP-HPLC method for estimation of Cefotaxime sodium in marketed formulations
Author: Lalitha N ; Sanjay Pai PN Journal: Journal of Basic and Clinical Pharmacy Year: 2010 Vol: 1 Issue: 1 Pages/record No.: 26-28

Genetic transformation of Vanda lilacina Teijsm. & Binnend. with a chitinase gene
Author: Witaya Pimda ; Sumontip Bunnag Journal: Advances in Agriculture & Botanics Year: 2010 Vol: 2 Issue: 1 Pages/record No.: 71-78

Emergence of CTX-M group 1 extended-spectrum ß-lactamase–producing Klebsiella pneumoniae strains in the community
Author: Branka Bedenić, ; Jasmina Vraneš, ; Zrinka Bošnjak, ; Tatjana Marijan, ; Ana Mlinarić-Džepina, ; Tamara Kukovec, ; Jasna Knežević, ; Maja Anušić, ; Nataša Beader, ; Petra Barl, ; Vladimira Leskovar, ; Smilja Kalenić, Journal: Medicinski Glasnik Year: 2010 Vol: 7 Issue: 1 Pages/record No.: 32-39

Effects of Chai-Qin-Cheng-Qi Decoction on cefotaxime in rats with acute necrotizing pancreatitis
Author: Li-Hui Deng, Da-Kai Xiang, Ping Xue, Hai-Yan Zhang, Lei Huang, Qing Xia Journal: World Journal of Gastroenterology Year: 2009 Vol: 15 Issue: 35 Pages/record No.: 4439-4443

Differential Methylation Pattern of RolA, B and C Genes of Agrobacterium rhizogenes in Nicotiana glauca and its Hybrid
Author: D.R.S. Suneetha ; A. Arundhati ; G.S. Rao ; P.V. Joshua Journal: Asian Journal of Plant Sciences Year: 2009 Vol: 8 Issue: 5 Pages/record No.: 361-367

Efficacy of current guidelines for the treatment of spontaneous bacterial peritonitis in the clinical practice
Author: Stefania Angeloni, Cinzia Leboffe, Antonella Parente, Mario Venditti, Alessandra Giordano, Manuela Merli, Oliviero Riggio Journal: World Journal of Gastroenterology Year: 2008 Vol: 14 Issue: 17 Pages/record No.: 2757-2762

THE EFFECTS OF FINE LACTOSE AS A THIRD COMPONENT ON AEROSOLIZATION OF CEFOTAXIME SODIUM FROM DRY POWDER FORMULATIONS
Author: ABDOLHOSEIN ROUHOLAMINI NAJAFABADI ; RAMIN ASGHARIAN ; HOSNIE TAJERZADEH ; KAMBIZ GILANI ; ALIREZA VATANARA ; MAJID DARABI Journal: DARU : Journal of Pharmaceutical Sciences Year: 2006 Vol: 14 Issue: 3 Pages/record No.: 151-154

Fenotipik dan molekuler karakterisasi patogen ESBL dipilih
Author: OSAyshaa, R. Dhamotharanb, mumtaj peermohammed c Jurnal: Jurnal Penelitian Farmasi Tahun: 2011 Vol: 4 Edisi: 2 Halaman / No catatan: 537-539

Perumusan dan Evaluasi Sodium Mikrokapsul Sefotaksim
Author: K. Shekhar *, M. Naga Madhu, B. Bindu Madhavi, Arjun G., B. Pradeep, David Banji. Jurnal: Jurnal Penelitian Farmasi Tahun: 2011 Vol: 4 Edisi: 2 Halaman / No catatan: 317-322

Persiapan dan studi biodistribusi 99mTc-sefotaksim sebagai agen lain pencitraan infeksi
Author: Seyedeh Fatemeh Mirshojaei; Mostafa Gandomkar, Reza Najafi, Mohamad Hosein Talebi; Mohamad mazidi Journal: Jurnal Iran Tahun Kedokteran Nuklir: 2010 Vol: 18 Edisi: Suppl 1 Halaman / No catatan: 154

Pengembangan dan validasi metode RP-HPLC untuk estimasi natrium Sefotaksim dalam formulasi dipasarkan
Author: Lalitha N; Sanjay Pai PN Jurnal: Jurnal Farmasi Tahun Dasar dan Klinis: 2010 Vol: Isu 1: 1 Halaman / No catatan: 26-28

Transformasi genetik Vanda lilacina Teijsm. & Binnend. dengan gen kitinase
Author: Witaya Pimda; Sumontip Bunnag Journal: Kemajuan Pertanian & Botanics Tahun: 2010 Vol: 2 Issue: 1 Pages / record No: 71-78

Munculnya CTX-M grup 1 diperpanjang-spektrum ß-laktamase yang menghasilkan strain Klebsiella pneumoniae dalam masyarakat
Author: Branka Bedenić,; Jasmina Vraneš,; Zrinka Bošnjak,; Tatjana Marijan,; Ana Mlinarić-Džepina,; Tamara Kukovec,; Jasna Knezevic,; Maja Anušić,; Nataša Beader,; Petra Barl,; Vladimira Leskovar,; Smilja Kalenić , Jurnal: Medicinski Glasnik Tahun: 2010 Vol: 7 Edisi: 1 Halaman / No catatan: 32-39

Efek Chai-Qin Qi-Cheng-Rebusan pada sefotaksim pada tikus dengan pankreatitis nekrosis akut
Penulis: Li-Hui Deng, Da-Kai Xiang, Xue Ping, Hai-Yan Zhang, Huang Lei, Qing Xia Journal: World Journal of Gastroenterology Tahun: 2009 Vol: 15 Edisi: 35 Halaman / No catatan: 4439-4443

Diferensial Metilasi Pola Gen Rola, B dan C dari Agrobacterium rhizogenes Nicotiana glauca dan di Hybrid
Author: D.R.S. Suneetha; A. Arundhati; G. S. Rao; P.V. Yosua Jurnal: Jurnal Asia Tahun Ilmu Tanaman: 2009 Vol: 8 Issue: 5 Halaman / No catatan: 361-367

Kemanjuran pedoman saat untuk pengobatan spontaneous bacterial peritonitis dalam praktek klinis
Author: Stefania Angeloni, Cinzia Leboffe, Antonella Parente, Mario Venditti, Alessandra Giordano, Manuela Merli, Oliviero Riggio Journal: World Journal of Gastroenterology Tahun: 2008 Vol: 14 Edisi: 17 Halaman / No catatan: 2757-2762

EFEK laktosa HALUS SEBAGAI KOMPONEN KETIGA PADA aerosol dari Natrium sefotaksim dari formulasi BUBUK KERING
Author: ABDOLHOSEIN ROUHOLAMINI Najafabadi; RAMIN ASGHARIAN, HOSNIE TAJERZADEH, Kambiz Gilani, Alireza VATANARA; Majid Darabi Journal: Daru: Jurnal Ilmu Farmasi Tahun: 2006 Vol: 14 Edisi: 3 Halaman / No catatan: 151-154
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Jurnal dengan kata kunci bioekivalensi atau bioavailabilitas antibiotik sefotaksim

2011-11-17T07:46:00.000-08:00

Jurnal dengan kata kunci bioekivalensi atau bioavailabilitas antibiotik sefotaksim. Silahkan dicek langsung ke sini http://journal.uii.ac.id/index.php/JIF/article/viewFile/478/389

Smoga bermanfaat.

Antipyretic journal list (kumpulan jurnal ilmiah dengan kata kunci Antipiretik

2011-11-17T07:34:00.000-08:00

Evaluation of Pharmacological Potentials of Methanolic leaf Extract of Madhuca longifolia (Sopteacae) against Pyrexia
Author: Goutam Kumar Jana*, Anshita Gupta, Deependra Soni, Subrata Debnath, Somezeet Panda Journal: Journal of Pharmacy Research Year: 2011 Vol: 4 Issue: 4 Pages/record No.: 1298-1299

A Study On Antipyretic Activity Of Capparis zeylanica Linn. Plant Methanolic Extract
Author: Amiya Ranjan Padhan, ; Anuj kumar Agrahari ; Ashutosh Meher Journal: International Journal of Pharma Sciences and Research Year: 2010 Vol: 1 Issue: 3 Pages/record No.: 169-171

Antipyretic and antibacterial activity of Chloranthus erectus (Buch.-Ham.) Verdcourt leaf extract: A popular folk medicine of Arunachal Pradesh
Author: Tag Hui ; Namsa Nima ; Mandal M ; Kalita P ; Das A ; Mandal S Journal: Indian Journal of Pharmacology Year: 2010 Vol: 42 Issue: 5 Pages/record No.: 273-276

Antinociceptive and antipyretic activities of Amaranthus viridis Linn. in different experimental models
Author: Kumar Ashok B.S. ; Lakshman K. ; Jayaveera K.N. ; Shekar Sheshadri D. ; Vivek C. Journal: Archives of Biological Sciences Year: 2010 Vol: 62 Issue: 2 Pages/record No.: 397-402

Synthesis, spectral characterization, and pharmacological screening of some 4-[{1-(aryl)methylidene}-amino]-3-(4-pyridyl)-5-mercapto-4H-1,2,4-triazole derivatives
Author: Siddiqui Anees ; Mishra Ravinesh ; Kumar Rajiv ; Rashid Mohd ; Khaidem Somila Journal: Journal of Pharmacy and Bioallied Sciences Year: 2010 Vol: 2 Issue: 2 Pages/record No.: 109-112

Preparation and evaluation of a new gel formulation of paracetamol
Author: Dr.Hassen A.H.Bennasir * ,Shanmugam sridhar * Journal: Journal of Pharmacy Research Year: 2009 Vol: 2 Issue: 8 Pages/record No.: 1269-1271

Analgesic, anti-inflammatory and antipyretic studies of Neolamarckia cadamba barks
Author: Sumanta Mondal*, Gouri Kumar Dash, Suman Acharyya. Journal: Journal of Pharmacy Research Year: 2009 Vol: 2 Issue: 6 Pages/record No.: 1133-1136

Antipyretic Activity of Different Fractions of Root Extract of Smilax chinensis Linn. (Liliaceae) in Albino Rats
Author: Goutam Kumar Jana 1*, Sanchita Das2, Ranabir Sahu2, Pallab Kanti Haldar 2, Saikat Dewanjee2 Journal: Journal of Pharmacy Research Year: 2009 Vol: 2 Issue: 6 Pages/record No.: 1026-1027

Analgesic, anti-inflammatory and antipyretic studies of Cleome rutidosperma DC. roots
Author: Sumanta Mondal*, Gouri Kumar Dash, Suman Acharyya, Dillip Kumar Brahma Journal: Journal of Pharmacy Research Year: 2009 Vol: 2 Issue: 5 Pages/record No.: 819-822

Evaluation of analgesic and antipyretic activities of Centratherum anthelminticum (L) kuntze seed
Author: Purnima A ; Koti B ; Tikare V ; Viswanathaswamy A.H.M ; Thippeswamy A.H.M ; Dabadi P Journal: Indian Journal of Pharmaceutical Sciences Year: 2009 Vol: 71 Issue: 4 Pages/record No.: 461-464

Evaluasi Potensi Farmakologi Ekstrak metanol daun dari Madhuca longifolia (Sopteacae) terhadap Pireksia
Author: Kumar Jana Goutam *, Anshita Gupta, Deependra Soni, Subrata Debnath, Somezeet Panda Journal: Jurnal Penelitian Farmasi Tahun: 2011 Vol: 4 Edisi: 4 Halaman / No catatan: 1298-1299

Sebuah Studi Pada Aktivitas antipiretik Dari Capparis zeylanica Linn. Ekstrak metanol Tanaman
Author: Amiya Ranjan Padhan,; Anuj kumar Agrahari; Ashutosh Meher Journal: Jurnal Ilmu Farmasi dan Tahun Penelitian: 2010 Vol: Isu 1: 3 Halaman / No catatan: 169-171

Antipiretik dan aktivitas antibakteri Homo Chloranthus (. Buch.-Ham) Verdcourt ekstrak daun: Sebuah obat rakyat populer Arunachal Pradesh
Author: Tag Hui, NAMSA Nima, Mandal M; Kalita P; Das A; Mandal S Journal: India Jurnal Farmakologi Tahun: 2010 Vol: 42 Issue: 5 Halaman / No catatan: 273-276

Antinociceptive dan antipiretik kegiatan Amaranthus viridis Linn. dalam model eksperimental yang berbeda
Author: Kumar Ashok B.S. ; Laksmana K.; Jayaveera K.N. ; Shekar Sheshadri D.; Vivek C. Journal: Archives of Biological Sciences Tahun: 2010 Vol: 62 Edisi: 2 Halaman / No catatan: 397-402

Sintesis, karakterisasi spektral, dan farmakologis skrining dari beberapa 4 - [{1 - (aril) methylidene}-amino] -3 - (4-piridil)-5-merkapto-4H-1 ,2,4-triazole derivatif
Author: Siddiqui Anees, Mishra Ravinesh, Rajiv Kumar, Mohd Rashid; Khaidem Somila Jurnal: Jurnal Ilmu Farmasi dan Tahun Bioallied: 2010 Vol: 2 Issue: 2 Pages / No catatan: 109-112

Persiapan dan evaluasi formulasi gel baru parasetamol
Author: Dr.Hassen AHBennasir *, Shanmugam Sridhar * Jurnal: Jurnal Penelitian Farmasi Tahun: 2009 Vol: 2 Issue: 8 Halaman / catatan No: 1269-1271

Analgesik, anti-inflamasi dan antipiretik studi gonggongan Neolamarckia cadamba
Author: Sumanta Mondal *, Gouri Kumar Dash, Suman Acharyya. Jurnal: Jurnal Penelitian Farmasi Tahun: 2009 Vol: 2 Issue: 6 Halaman / No catatan: 1133-1136

Kegiatan antipiretik Pecahan berbeda dari Ekstrak Akar chinensis Smilax Linn. (Liliaceae) pada Tikus Albino
Author: Kumar Jana Goutam 1 *, Sanchita Das2, Ranabir Sahu2, Pallab Kanti Haldar 2, Saikat Dewanjee2 Journal: Jurnal Penelitian Farmasi Tahun: 2009 Vol: 2 Issue: 6 Halaman / No catatan: 1026-1027

Analgesik, anti-inflamasi dan antipiretik studi Cleome rutidosperma DC. akar
Author: Sumanta Mondal *, Gouri Kumar Dash, Suman Acharyya, Dillip Brahma Kumar Journal: Jurnal Penelitian Farmasi Tahun: 2009 Vol: 2 Issue: 5 Halaman / No catatan: 819-822

Evaluasi kegiatan analgesik dan antipiretik benih Centratherum (L) anthelminticum kuntze
Author: Purnima A; Koti B; Tikare V; Viswanathaswamy AHM, Thippeswamy AHM; Dabadi P Journal: India Jurnal Ilmu Farmasi Tahun: 2009 Vol: 71 Edisi: 4 Halaman / No catatan: 461-464

Analgesic and Antipyretic Activity of Cassia occidentalis Linn

2011-11-17T00:44:00.000-08:00

Abstract:

Cassia occidentalis Linn (Caesalpiniaceae), a perennial plant of Palakkad, Southern India, is an ayurvedic plant with huge medical importance. The ethanol and water extracts of Cassia occidentalis leaves were screened for antinociceptive activity using acetic acid induced writhing test, hot plate test and tail immersion test in mice. In a similar way a screening exercise was carried out to determine the antipyretic potential of the extract using yeast induced pyrexia method in rats. The results of the statistical analysis showed that ethanol and water extracts of Secamone emetica had significant (p<0.01) dose dependent antinociceptive and antipyretic properties at 150 and 300 mg/kg. ). The inhibition produced by the highest dose (300 mg/kg) of the extracts was significantly (P90.01) lower than that by acetylsalicylic acid (100 mg/kg). Both the ethanolic and water extracts of Cassia occidentalis showed significant (P90.01) effect on pyrexia induced by yeast. Hence present investigation reveals the antinociceptive and antipyretic activities of the ethanolic and water extracts of the leaves of Cassia occidentalis. This seems to provide a rationale for the use of this plant in pain and inflammatory disorders.
Key words: Cassia occidentals, Analgesic activity, Antipyretic activity, Prostaglandin

Abstrak:

Cassia occidentalis Linn (Caesalpiniaceae), tanaman abadi Palakkad, India Selatan, adalah tanaman ayurveda dengan kepentingan medis yang sangat besar. Ekstrak etanol dan air daun Cassia occidentalis disaring untuk aktivitas antinociceptive menggunakan asam asetat diinduksi menggeliat tes, piring uji panas dan uji perendaman dalam ekor tikus. Dalam cara yang sama latihan skrining dilakukan untuk menentukan potensi antipiretik dari ekstrak menggunakan ragi diinduksi pada tikus metode pireksia. Hasil analisis statistik menunjukkan bahwa etanol dan ekstrak air Secamone emetica telah signifikan (p <0,01) antinociceptive tergantung dosis dan sifat antipiretik pada 150 dan 300 mg / kg. ). Penghambatan yang dihasilkan oleh dosis tertinggi (300 mg / kg) dari ekstrak secara signifikan (P90.01) lebih rendah dibanding oleh asam asetilsalisilat (100 mg / kg). Baik ekstrak etanolik dan air Cassia occidentalis menunjukkan signifikan (P90.01) efek pada demam yang disebabkan oleh ragi. Oleh karena itu penelitian ini mengungkapkan kegiatan antinociceptive dan antipiretik dari ekstrak etanol dan air daun Cassia occidentalis. Hal ini tampaknya untuk memberikan alasan untuk penggunaan tanaman ini di rasa sakit dan gangguan inflamasi.

Kata kunci: Cassia occidentals, aktivitas Analgesik, antipiretik aktivitas, prostaglandin

Download full article in PDF here : http://idosi.org/wasj/wasj11%2810%29/3.pdf

Efek Antipiretik Infus Rimpang Jahe (zingiber officinale Rosc) pada Kelinci (Oryctolagus cuniculus)

2011-11-13T23:27:00.000-08:00

Antipyretics effects Infusions Ginger Rhizome (Zingiber officinale ROSCs) in rabbits (Oryctolagus cuniculus)

abstract

This study aimed to determine the effects of the rhizome extract antipyretic. This study used 12 rabbits that is 3 test group who were given infusions of ginger rhizome with a concentration of 5%, 10%, and 15% w / v, a comparison group who were given paracetamol suspension of 1%. The provision made orally. Before treatment, the rabbits first didemamkan by injecting a solution of 10% sterile peptone intraperitonal. Data were analyzed with linear regression relationship of time and measured rectal temperature, then analyzed by completely randomized rancanang. The results showed that the infusion of ginger rhizome (Zingiber officinale ROSCs) with a concentration of 5-15% have antipyretic effects on rabbit and the infusion of 15% giving effect was not statistically significantly different from the effects of paracetamol 1%.

Key words: antipyretic, ginger rhizome, rabbit

Efek Antipiretik Infus Rimpang Jahe (zingiber officinale Rosc) pada Kelinci (Oryctolagus cuniculus)

Abstrak

Penelitian ini dimaksudkan untuk mengetahui adanya efek antipiretik ekstrak rimpang tersebut. Penelitian ini menggunakan 12 ekor kelinci yaitu 3 kelompok uji yang diberi infus rimpang jahe dengan konsentrasi 5 %, 10 %, dan 15 % b/v, satu kelompok pembanding yang diberi suspensi parasetamol 1 %. Pemberian dilakukan peroral. Sebelum perlakuan, kelinci terlebih dahulu didemamkan dengan menyuntikkan larutan pepton steril 10 % secara intraperitonal. Data dianalisis dengan regresi linier hubungan waktu dan suhu rektal terukur, kemudian dianalisis dengan rancanang acak lengkap. Hasil penelitian menunjukkan bahwa infus rimpang jahe (Zingiber officinale Rosc) dengan konsentrasi 5-15 % mempunyai efek antipiretik pada kelinci dan infus 15 % memberikan efek yang secara statistik tidak berbeda nyata dengan efek parasetamol 1 %.

Kata kunci : antipiretik, rimpang jahe, kelinci

Download full article by visit this link : http://isjd.pdii.lipi.go.id/admin/jurnal/1210814.pdf

Daftar Jurnal Penelitian Kimia dan Farmasi Volume 3 Edisi 5 2011

2011-11-13T22:31:00.001-08:00

Volume 3 Edisi 5 2011: Jurnal Penelitian Kimia dan Farmasi

Deskriptor studi topologi berbasis derivatif testosteron
Deepa Singh dan Mohd. Adil Khan
Halaman: 1-14

Penyembuhan luka aktivitas Capparis zeylanica (root)
Chandan Das, Sujit Dash, Durga Charana Sahoo, Abinash Kumar Sahu, Raghunandan Hota dan Rout Dolley
Halaman: 15-19

Sintesis dan aktivitas antikanker in vitro 9-kloro-3-siano-8-fluoro-2-methylthio-4-okso-4H-pyrimido [2, 1-b] [1, 3] benzothiazole dan 2 - derivatif diganti
P. Ravi Prasad, Sanjay D. Shinde, Gangadhar S. Waghmare, V. Lakshma Naik, K. Bhuvaneswari dan Sharad V. Kuberkar
Halaman: 20-27

Skrining fitokimia Thespesia populnea (L.) dan Tridax procumbens Soland L.
N. Savithramma, M. Lingga Rao dan G. Bhumi
Halaman: 28-34

GC / MS penentuan komponen bioaktif dari Trigonella foenum grecum
V. Priya, R. K. Jananie dan K. Vijayalakshmi
Halaman: 35-40

Molar kepunahan koefisien dari beberapa asam amino
Pravina P. Pawar dan Govind K. Bichile
Halaman: 41-50

Kinerja pabrik limbah pengobatan dengan referensi khusus untuk Badwai (STP) Bhopal, (INDIA)
Ram Kumar Kushwah, Avinash Bajpai, Suman Malik
Halaman: 51-55

Penyembuhan luka kegiatan Mimosa pada tikus wistar Pudica albino
Goli.Venkateshwarlu, Kanakam.Vijayabhaskar, G. Pavankumar, P. Kirankumr K. Harishbabu dan Ravi malothu
Halaman: 56-60

Sintesis, karakterisasi dan aktivitas antibakteri dari beberapa studi triazolothiadiazolylquinolines
M. K. Shivananda dan Shet Prakash M
Halaman: 61-66

DFT berdasarkan studi interaksi orto, meta dan para turunan dari piridin dan turunan fenol dengan halida dari titanium dan silikon
G. Mishra, V. Tanmya, P. P. Singh
Halaman: 67-81

Pengaruh senyawa farmasi Omeprazol aktif, pada korosi baja ringan dalam larutan asam klorida
Sudheer dan M. A. Quraisy
Halaman: 82-92

HPTLC skrining asam amino dari ekstrak alkohol dari empat spesies molluscan di sepanjang Pantai Timur Selatan India
Sadasivam Giji, Pachiyappan Abirami, Muthuvel Arumugam dan Thangavel Balasubramaniam
Halaman: 93-100

Prosopis Juliflora Karbon dan Activated Carbon Komersial dalam penghapusan COD dari larutan berair
KK Sivakumar, MS Dheenadayalan dan S. Mahalakshmi
Halaman: 101-107

Kelebihan Volume dan viskositas untuk Sistem Biner 2 - Propanol dengan alkil asetat pada 303,15 K
K. Vasudha, D. Vijaya Kumari, G. Yuvaraja, A. Krishnaiah
Halaman: 108-115

Studi kinetik pembentukan N-Salicylidene-anilin Spectrophotomerically
Anil K. Bhausaheb Magar S. Kirdant, Vinod A. Shelke, Sunil G. Shankarwar dan Trimbak K. Chondhekar
Halaman: 116-123

Fisiko-kimia dan karakteristik farmakologi dari minyak biji rothiana Euphorbia
Rajesh D. Hunashal, Rajani M. Bagewadi dan D. Satyanarayana
Halaman: 124-129

Sintesis dan aktivitas antimikroba azines asimetris berasal dari naphtho [2,1-b] furan
K. Veena 1, M. Ramaiah, K. Shashikaladevi, TS Avinash dan VP Vaidya
Halaman: 130-135

Sintesis baru b-D-glukuronida: b-D-glucuronosyl-5-(3-aril-1H-pyrazol-5-il) -1,2-benzisoxazole-3-karboksilat
Rajendra Krushnaji Wanare
Halaman: 136-144

Fitokimia dan antimikroba penelitian pada daun Spilanthes acmella
Shefali Arora, Saurabh Vijay Kumar dan Deepak
Halaman: 145-150

Studi banding potensi agro-pabrik Kertas nutrisi limbah dan sintetis (DAP) di Vigna unguiculata L. (Walp) Cowpea
A. K. Chopra, Sachin Kumar Srivastava dan Vinod
Halaman: 151-165

Pengaruh fraksi berat elemen-elemennya yang berbeda pada koefisien redaman total beberapa senyawa biologis penting
Pravina P. Pawar dan Govind K. Bichile
Halaman: 166-173

TPA gas pemulihan dan pemanfaatannya di India: Status saat ini, prospek potensial dan implikasi kebijakan
Faisal Siddiqui dan Zia Khan Mohd Emran
Halaman: 174-183

Sintesis dan karakterisasi dari N-(2-thienylmethylidene) -1 - propanamine kompleks dan logam
I. E. Otuokere dan A. J. Chinweuba
Halaman: 190-195

Analisis kuantitatif civetone dan normuscone dalam sekresi dari Viverricula indica dan dalam pengobatan aromatik dengan kromatografi gas-spektrometri massa
Thidarat Duangyod, Chanida Palanuvej dan Nijsiri Ruangrungsi
Halaman: 196-204

Fitokimia skrining dan resistensi antimikroba dari Alseodaphne semecarpifolia Nees
Charles A dan Alex Ramani V
Halaman: 205-211

Penampang fotolistrik disimpulkan dari bagian foton lintas interaksi diukur total untuk lima elemen (24 Pravina P Pawar dan G K Bichile
Halaman: 212-217

Antioksidan aktivitas dan analisis fitokimia jamur endophytic terisolasi dari Lobelia nicotianifolia
Nitya. K. Murthy, KC Pushpalatha dan Chandrashekhar G. Joshi
Halaman: 218-225

Pembentukan konstanta dan parameter termodinamika kompleks ion logam bivalen dengan 3-amino-5-metil isoxazole Schiff basis dan N, N; N, O dan O, O ligan donor dalam larutan
K. Kiranmai, Y. Prashanthi, Vijay Kumar Chityala dan Shivaraj
Halaman: 226-233

Sintesis dan karakterisasi dari beberapa pirimidin baru melalui Kondensasi aldol
K. Suneel Kumar, A. Vamsi Kanth, K. Tatendra Reddy, G. Omprakash
Halaman: 234-252

Pengaruh suhu dan pelarut pada ekstraksi senyawa fenolik total dari Ficus Carica daun
Y. Jahangiri, H. Ghahremani, J. Abedini Torghabeh, E. Ataye Salehi
Halaman: 253-259

Antimikroba kegiatan dari beberapa-satu turunan tersubstitusi quinoxalin-2 (1H)
V. Ratnadeep Ghadage dan J. Pramono Shirote.
Halaman: 260-266

Koefisien Atenuasi massa dari Cr, Ni, Cu, dan unsur Ag (24 Pravina P. Pawar dan G. K. Bichile
Halaman: 267-273

Ultrasonik investigasi asosiasi molekul dalam campuran biner NMP dengan benzenes diganti pada 308,15 K, 318,15 dan tekanan atmosfer
D. Bala Karuna Kumar, K. Rayapa Reddy, G. Srinivasa Rao, GV Rama Rao dan C. Rambabu
Halaman: 274-280

Optimasi Parameter Fermentasi untuk Maksimalisasi produksi D Actinomycin
M Khan dan C. K. Tripathi M
Halaman: 281-289

Kuantitatif struktur-aktivitas hubungan matriks metalloproteinase inhibitor berdasarkan deskriptor topologi
Abhishek Giri, Bhuwan B. Mishra, Priyanka Tripathi, Prahlad P. Agrawal dan Pashupati P. Singh
Halaman: 290-305

Studi sifat akustik dan termodinamika Glycine dalam air suling ganda pada temperatur yang berbeda
Shilpa Mirikar, Pravina P. Govind Pawar dan K. Bichile
Halaman: 306-310

Ammoxidation dari 3-picoline lebih dari antimon dipromosikan katalis VPO dan alumina didukung Sb-VPO katalis
Manohar Basude
Halaman: 311-322

Struktur molekul, spektroskopi (FT-IR, FT-Raman, NMR) studi dan orde pertama hyperpolarizabilities molekul asam 5-amino-2-hidroksibenzoat (5A2HBA) oleh ab initio HF dan metode fungsional kepadatan
S. Muthu dan E. Isac Paulraj
Halaman: 323-339

Dalam kegiatan Vitro antioksidan Breynia Vitis-Idaea ekstrak
Chandrashekar. G. Joshi, Gopal M dan Vaigundan D
Halaman: 340-347

Ultrasonik studi dinamika molekuler di beberapa campuran biner
K. Rajathi, S. J. Askar Ali dan A. Rajendran
Halaman: 348-358

Campuran logam Fe-Mo dengan basa Schiff kompleks dari triethylenetetramine & diethylenetriamine
R. Vijayanthimala, C.H. Swathy dan Mercy Lalrohluohmar
Halaman: 359-362

Adsorpsi studi pewarna metilen biru menggunakan disiapkan biaya rendah Karbon yang diaktifkan Kaza
M. Nageswara Rao, Y. Hanumantha Rao, Ch. Chakrapani, Ch. Suresh Babu, BV Rajeswara Reddy, P. Haritha dan Kaza Somasekhara Rao
Halaman: 363-375

Dampak Irigasi Distillery Spentwash pada Tumbuh dan Pertumbuhan Tagetes (Asteraceae) tanaman berbunga
S. Chandraju, C. Thejovathi dan CS Chidan Kumar
Halaman: 376-381

Satu pot sintesis 2,3-dihidro-1H-1 ,5-benzodiazepin bawah kondisi bebas pelarut menggunakan klorida stannous anhidrat sebagai katalis
Shikha Sharma, D. N. Prasad dan Rajesh K. Singh
Halaman: 382-389

Sintesis, karakterisasi dan evaluasi turunan dari Ciprofloxacin (1-cyclopropyl-6-fluoro-4-okso-7-[4 - (karbonil fenil) piperazin-1-il] -1, asam 4-dihydroquinoline-3-karboksilat) dan mereka kompleks
Y. Thakre M. dan M. Choudhary D.
Halaman: 390-398

Sintesis dan charecterization dari beberapa (III) kompleks Lantanida dengan N-(furfuralidene)-N ¢-isonicotinoylhydrazine
S. Devi Satyabhama dan Ak. Manihar Singh
Halaman: 399-406

DNA Binding dan Pembelahan Studi Fe (II) dan (II) Zn Kompleks yang mengandung ligan campuran dari 1,10-phenanthroline dan 2-hidroksi-4-metil-1 ,8-naphthyridine
B. Sreekanth, G. Krishnamurthy, HS Bhojya Naik, TK Vishnuvardhan, ND Shashikumar dan MR Lokesh
Halaman: 407-419

Skrining aktivitas antimikroba invitro Barlaria buxifolia Linn. (Acanthaceae) ekstrak batang
Shivakumar. B. S, M. Ramaiah, Hema M. R, VP Vaidya dan Abida Begum
Halaman: 420-424

Pengembangan dan Validasi Metode HPLC Stabilitas-Mengindikasikan untuk Analisis suksinat Desvenlafaxine dalam Kehadiran Produk Degradasi asam yang Terimbas di Persiapan Massal dan Farmasi
Bahia Abbas Moussa, Ramzia Ismail El-Bagary dan Yasmin Abdullah Al-Eryani
Halaman: 425-437

Sintesis dari serangkaian 2-metil-4-(fenil tersubstitusi) -1,5 - benzodiazepin dan evaluasi aktivitas antibakteri
Archana Y. Vibhute, Sainath B. Zangade, Vasant M. Gurav dan Yeshwant B. Vibhute
Halaman: 438-442

QSAR studi inhibitor Anthrax Lethal melalui Indeks Quantum Kimia
Biswajit Das, Pranab Ghosh, Asim K Bothra
Halaman: 443-449

Perumusan dan evaluasi dari mulut melarutkan tablet anti-alergi dari dihidroklorida levocetrizine
Sandeep Saini, Arun Nanda, Monika Hooda dan Komal, J. bertitik
Halaman: 450-455

Sintesis 4 - semicarbazones tersubstitusi aril dan mereka terpene derivatif: Sebuah perancah baru sebagai agen antikonvulsan
SN Pandeya, Ahsan Ahmed Khan dan Anupam Srivastava
Halaman: 456-464

Anthelmintik potensi tanaman obat tertentu ethano Negara Uttarakhand, India
Bhawana Sati, Hemlata Sati, Sarla Saklani, Prakash Chandra Bhatt, Somesh Thapliya
Halaman: 465-467

Studi aktivitas antikonvulsan dari pada tikus albino Pentazocine
Praveen Panchaksharimath, Shailender Singh dan Siddappa Devaru
Halaman: 468-472

Studi anti-inflamasi aktivitas Thespesia populnea Linn. pada obat diinduksi tikus albino jantan
Elakkiya. S dan Ananthi. T
Halaman: 473-477

Penghapusan Alizarin Red S (Dye) dari Media berair dengan menggunakan Cynodon dactylon sebagai adsorben
J. Samusolomon dan P. Martin Devaprasath
Halaman: 478-490

Pengaruh biomolekul pengkelat pada kelarutan kalsium oksalat: Sebuah studi in vitro
Patel, P. B., Vadalia, K. R.
Halaman: 491-495

Studi karakteristik fisikokimia air tanah dari lokasi yang berbeda di kota Nanded
Ditjen Kolhatkar, SM Bhagat, LP Shinde dan MN Deshpande.
Halaman: 496-500

Efek imunostimulan halicacubum Cardiospermum terhadap Vibrio parahaemolyticus pada udang windu Penaeus monodon
T. Rajasekar, J. Usharani, M. Sakthive dan B. Deivasigamani
Halaman: 501-513

Kimia profil dan aktivitas antibakteri Punica granatum L. terhadap patogen menyebabkan Mastitis Bovine
Gopinath. S. M, Suneetha. T. B, Mruganka, V. D, Ananda. S,
Halaman: 514-518

Indole: Molekul kegiatan farmakologis yang beragam
Ramesh Dhani, A. Avinash, SK Salenaagina, MV Saicharan Teja, P. Masthanaiah, P. Raja Rathnam dan V. Chandana Silpa.
Halaman: 519-523

Katalis dan Allylation Gratis Pelarut aldehida dengan allyltributylstannane bawah iradiasi gelombang mikro
Pranjal P Bora, H Atoholi Sema, Barisha Wahlang dan Ghanashyam Bez
Halaman: 524-531

Penghapusan Ion Tembaga dari solusi berair oleh Carbon Activated biaya rendah dari Bark Populnea Thespesia
R. Prabakaran, S. Arivoli, M. Hema dan C. Kamatchi
Halaman: 532-543

Identifikasi Pinitol dalam ekstrak tanaman dengan HPTLC
Shubashini K. Sripathi, Poongothai, G dan Lalitha, P
Halaman: 544-549

In vitro-Dalam Korelasi vivo: Aplikasi dalam pengembangan farmasi bentuk berbagai dosis
Bankim C Nandy, Sandipan Roy, Bhaskar Mazumder, Kailash C Meena, Dharmedra Ahuja, Manju Makhija, Swati Jain, stuti Sharma, Arti Shrivastava, Priya Saxena
Halaman: 550-564

Sequential Ekstraksi Logam Umum (Na, K, Ca dan Mg) Dari Permukaan Tanah
Bhupen K Baruah, Bhanita Das, Ansarul Haque, Chitrani Medhi; Abani K Misra
Halaman: 565-573

Awal phyto-kimia evaluasi ekstrak daun Cassia lima Spesies
Usha Veerachari dan A. K. Bopaiah
Halaman: 574-583

Desain & Fabrikasi Tramadol HCl Multiparticulate dimuat Colon Sistem Pengiriman Obat Target
Poonam Kushwaha, Sheeba Fareed, Sanju Nanda dan Anuradha Mishra
Halaman: 584-595

Kolorimetri penentuan hidroklorida Ziprasidone dalam formulasi farmasi
G. Usha Rani, B. Chandrasekhar dan D. Devanna
Halaman: 596-602

Pencegahan bioakumulasi kadmium oleh herbal adaptogen: Spirulina platensis
Deepti Gaurav, Shabad Preet dan KK Dua
Halaman: 603-608

Sintesis aktivitas, antikonvulsan & karakterisasi spektral dari beberapa derivatif thiazolidinone baru
Tejprakash Singh, Pramod Kumar Sharma, Sambhu Charan Nitin Kumar Mondalc dan
Halaman: 609-615

Pengaruh astragalin pada kegiatan enzim membran terikat pada toksisitas pada tikus albino leadacetate
R. Anuradha dan Palaniyandi Krishnamoorthy
Halaman: 616-620

Karsinogen kimia dan Risiko Kanker: Sebuah Tinjauan
Ashwani Arya, Sandeep Arya dan Arya Minakshi
Halaman: 621-631

Phenylboronic asam-Dikatalisis Sintesis 9,9-Dimetil-12-fenil-9, 10 - dihidro +8 H-benzo [a] xanthen-11 (12H)-salah satu Derivatif
SV Goswami, PB Thorat, SS Dhone dan SR Bhusare
Halaman: 632-635

Sintesis n'-karbamoil-N-[(6-chloropyridin-3-il) metil] ethanimidamide
Madhukar Deshmukh dan Chetan Shripanavar
Halaman: 636-637

Sebuah studi Perbandingan aktivitas antibakteri secara invitro ekstrak nimba dan miswak terhadap cariogens diisolasi dari pasien karies gigi
Sorna Kumari H,. T. Rajasekar, A. dan H. Shahanas Anandhi Begum
Halaman: 638-645

Evaluasi aktivitas ansiolitik ekstrak etanol Pisonia grandis R. Br daun pada tikus
Habibur Rahman, A. Elumalai, M. Chinna Eswaraiah dan Dipankar Bardalai
Halaman: 646-652

Antihyperglycemic Mangifera indica aktivitas Linn. di alloxan diabetes tikus diinduksi
P. Kemasari, S. Sangeetha dan P. Venkatalakshmi
Halaman: 653-659

FT-IR Studi e-plastik yang diperoleh dari komputer usang
Gupta Reena, Sangita, dan Kaur Verinder
Halaman: 660-667

Quantum Kimia studi tentang struktur Molekul, Kamas Optical Properties dan vibrasi Linear orto dan meta-Fluorobenzaldehyde
Onkar Prasad, Amarendra Kumar, Vijay Narayan, Hriday N. Mishra, Rajesh K. Srivastava dan Leena Sinha
Halaman: 668-677

Kinetika dan mekanisme oksidasi dari 2-naftol oleh nicotiniumdichromate
M. Vellaisamy, K. Suryakala dan M. Ravishankar
Halaman: 678-681

Sintesis, karakterisasi dan Mikroba Studi Kompleks Cu (II) dan Ni (II) dengan thiosemicarbazone
S. Shivhare dan Mangla Dave Gautam
Halaman: 682-688

Fitokimia evaluasi dengan GC-MS dan aktivitas antihyperglycemic dari Mucuna pruriens pada diabetes pada tikus diinduksi Streptozotocin
Anusha Bhaskar, Nithya V dan Vidhya VG
Halaman: 689-696

Efektivitas ekstrak daun Murraya koenigii pada beberapa strain bakteri dan jamur dengan metode difusi disk
Mohar Singh Argal, Sanjay Kumar, Hotam Singh Choudhary, Ravindra M Thakkar, Santosh K Verma, Chandrabhan Seniya
Halaman: 697-704

Spektrofotometri estimasi Cefixime dan ofloksasin dalam formulasi tablet
Amit Kumar, Sanju Nanda dan Rajiv Chomwal
Halaman: 705-709

Antioksidan dan aktivitas antibakteri dari beberapa derivatif chalcone novel dan sintesis mereka dengan metode konvensional dan iradiasi gelombang mikro
Muhammad. Rayees Ahmad, V. Girija Sastry, Nasreen Bano, Syed anwer, G. Kumaraswamy
Halaman: 710-717

Fabrikasi nano-komposit TiO2/Ag2S melalui metode baru untuk degradasi fotokatalitik p-xilena & chlorophenol
H. Mossalayi, A. Moghimi
Halaman: 718-724

Anti-depresi potensi obat herbal: Sebuah Tinjauan
Hitesh K. Dhamija, Bharat Parashar dan Joginder Singh
Halaman: 725-735

Aseton ekstrak Mete (Anacardium occidentale, L.) terhadap Methicillin shelliquid Staphylococcus aureus resisten (MRSA) dengan konsentrasi penghambatan minimum (MIC) kacang
Lakshmana Swamy Parasa, T. Sunita, K. Babu Rao, A. Hanumantha Rao, J. Srinivasa Rao dan L. Arun Kumar Cyril
Halaman: 736-742

Fabrikasi nano perak sulfida diolah poli vinil titanium oxidein alkohol PVA untuk degradasi fotokatalitik matrice etanol
H. Mossalayi, F. Oshal
Halaman: 743-749

Oksidasi senyawa kimia: Kinetika dan pendekatan mekanistik
SR Gour, BS Dhobal, Sayyid Husain dan Mazahar Farooqui
Halaman: 750-761

Penentuan tamsulosin dalam bentuk sediaan farmasi massal dan spektrofotometri UV dengan metode
Manish Kumar Thimmaraju, Venkat Rao, Hemanth.K dan Siddartha.K
Halaman: 762-767

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amphetamine

2011-11-13T21:59:00.000-08:00

One of the drug compounds that are currently becoming more the trend because of the use of amphetamines that are abused. These drugs are among the most widely used to get a hallucinogenic effect. Of course, with usage above the maximum dose

Amphetamine was first synthesized in the late 1920s and introduced to the practice of medicine in 1936. Dextroamphetamine is a leading member of the group even though many other amphetamines and amphetamine substitutes such as methamphetamine, penmetrazin, methyl penidat dams are introduced next. The number of amphetamine analogues with psychoactive effects continue to multiply. The main group of new members was 2.5-4-metilamfetamin dimetoksi, and entry list currently includes methamphetamine (MDA) and metilendioksimetamfetamin (MDMA).

Amphetamine and its derivatives namely MA (methamphetamine) and MDMA (methylene-dioxy-meth-amphetamine), included into the class of psychotropic drugs that have a strong stimulant effect. In medical science amphetamine used to treat narcolepsy, hiperkinesis in children, and obesity. However, the use of amphetamines for the treatment of overdose can cause dependence and addiction. Therefore the use of amphetamines for therapy is reduced because of the possibility of misuse.

Mechanism of action

Amphetamines stimulate the central nervous system work release catecholamines (epinephrin, norepineprin, and dopamine) in the central synapse and inhibits neurotransmitter release by increasing entecholamin, including dopamine. So that neurotransmitters remain in the synapse with a higher concentration within a period that is longer than usual. All of the nervous system will affect a given excitation.

Clinical effects of amphetamines will appear within 2-4 hours after use. This compound has a half-life of 4-24 hours and is excreted via the urine as much as 30% in the form of metabolites. Metabolite amphetamine hidroksiamfetamin consists of p-, p-hidroksinorepedrin, and penilaseton.

because of the short half-life effects of this drug is relatively fast and may soon terekskresikan, it is becoming one of its own difficulties for testing against the user, when testing was conducted more than 24 hours, the number of secondary metabolites in the urine contained very little and can not be longer be detected by KIT.

Abuse

Abuse of amphetamines began in the 1940s, in which chemicals are present in large quantities as inhalers used for nasal decongestants. One pattern of abuse of amphetamines is called, Äúlari, Äù, namely the repetition of intravenous injection conducted himself to get, Äúserangan, Äù (a reaction like an orgasm) followed by a sense of euphoria and mental preparedness are strong. The pattern of abuse of amphetamines has been developed which shaped crystal methamphetamine (ice) sucked, at smoke that delivers a bolus to the brain, like with intravenous administration. Because the service life of methamphetamine is much longer, intoxication may last for several hours after smoking one time.

Amphetamine poisoning generally occurs because of abuse to cause dependence. Characterized by increased alertness and confidence, euphoria, behavioral ekstrovet, talkative, talking fast, lose the desire to eat and sleep, tremors, dilated pupils, tachycardia, and severe hypertension, can also cause excitability, agitation, delusions, paranoia, and hallucinations with violent behavior.

Analgesic and Antipyretic activity of whole parts of Sphaeranthus indicus Linn.

2011-11-12T05:16:00.000-08:00

Analgesic and Antipyretic activity of whole parts of Sphaeranthus indicus Linn.
B.K. Nanda1*, J. Jena2, B.Rath2, B.R.Behera1
1* Dadhichi College of Pharmacy, Sundergram, Cuttack, Orissa
2Department of Pharmacology, V.S.S Medical College, Sambalpur, Orissa
________________________________________________________________________
Abstract

The aim of the present study is to investigate the analgesic and antipyretic activity of whole parts of the plant Sphaeranthus indicus Linn. (Compositae) on albino rats by Eddy’s hot plate, Tail immersion and Brewer’s yeast induced pyrexia method respectively. Dried powder plant materials were subjected to sucessesive solvent extraction taking Petroleum ether, Benzene, Chloroform, Ethanol and triple distilled water. The different extracts at a dose of 200mg/kg and 400mg/kg body weight were subjected to analgesic and antipyretic activity. The petroleum ether, chloroform and ethanol extracts showed significant analgesic activity in both doses (p<0.001 & p<0.01) from 1 hour onwards as compared to the standard drug diclofenac sodium. The chloroform and ethanol extracts showed potential significant antipyretic activity (p<0.05) from 1 hour onwards where as aqueous extracts exhibit activity from 2 hours onward as compared to the standard drug paracetamol amongst various extracts.

Keyword: Analgesic, Antipyretic, Sphaeranthus indicus Linn.

To download full article of this journal. Please visit this link : http://jocpr.com/first-issue/JOCPR-19.pdf

A Study On Antipyretic Activity Of Capparis zeylanica Linn. Plant Methanolic Extract

2011-11-12T05:02:00.000-08:00

Amiya Ranjan Padhan et. al. / International Journal of Pharma Sciences and Research (IJPSR) Vol.1(3), 2010, 169-171

A Study On Antipyretic Activity Of Capparis zeylanica Linn. Plant Methanolic Extract

Amiya Ranjan Padhan*, Anuj kumar Agrahari , Ashutosh Meher 1. The Pharmaceutical College, Department of Pharmacognosy, Samaleshwari vihar, Tingipali, Barpali - 768029, Bargarh, Odisha, India

ABSTRACT:

Objective - The objective of the present work was to study the antipyretic activity of plant Capparis zeylanica Linn. belonging to family Capparaceae, known as “Karambha” in Sanskrit & “Asadhua” in Oriya. Materials & Methods - The Methanolic extract was taken for the study and evaluated for antipyretic activity using Brewer’s yeast induced pyrexia in Wister strain albino rats. The methanolic extract at a dose of 100mg/kg & 200mg/kg were evaluated for antipyretic activity. Result - The extract of C. zeylanica plant showed a significant (P < 0.01) dose dependent antipyretic effect in yeast induced elevation of body temperature in experimental rats. Conclusion - The Methanolic extract of Capparis. zeylanica Linn. plant have significant antipyretic activity when compared with the standard drug. So. It can be recommended for further studies.

Key – words: Capparis zeylanica plant, Methanolic extract, Antipyretic activity, Brewer’s yeast.

Download full article by click this url : http://www.ijpsr.info/docs/IJPSR10-01-03-01.pdf

Antinociceptive and Antipyretic Activities of Amaranthus Viridis Linn in Different Experimental Models

2011-11-12T04:51:00.000-08:00

Antinociceptive and Antipyretic Activities of Amaranthus Viridis Linn in Different Experimental Models

Bagepalli Srinivas Ashok Kumar 1*, Kuruba Lakshman 2, Korala Konta Narsimha Jayaveera 3,
Devangam Sheshadri Shekar 4, Chinna SwamyVel Muragan 4, and Bachappa Manoj 1
1. Department of Pharmacognosy, Sri K.V.College of Pharmacy, Chickballapur, Karnataka, India
2. Department of Pharmacognosy, PES College of Pharmacy, Bangalore, Karnataka, India
3. Department of Chemistry, Jawaharlal Nehru Technological University of College of Engineering, Anantapur,
Andhra Pradesh, India
4. Department of Pharmacology, Sri K.V.College of Pharmacy, Chickballapur, Karnataka, India

Abstract

Methanolic extract of whole plant of Amaranthus viridis L (MEAV), was screened for antinociceptive activity using acetic acid induced writhing test, hot plate test and tail immersion test in mice. In a similar way a screening exercise was carried out to determine the antipyretic potential of the extract using yeast induced pyrexia method in rats. Administration of the extracts was applied to both laboratory animals at the doses of 200 and 400 mg/kg body weight, respectively. The results of the statistical analysis showed that MEAV had significant (p<0.01) dose dependent antinociceptive and antipyretic properties at 200 and 400 mg/kg. Hence present investigation reveals the antinociceptive and antipyretic activities of methanolic extract of Amaranthus
viridis.

Keywords: Analgesics, Animals, Dose response relationship, Methanol, Plant extracts

Download full article by click this url : http://www.ajmb.org/PDF/En/FullText/22.pdf

Kumpulan jurnal tentang Paprika (Capsicum annuum L.)

2011-11-11T22:02:00.001-08:00

Influence of parental germplasm for fruit characters in F1, F2 and F3 generations of pepper (Capsicum annuum L.)
Author: Zečević Bogoljub ; Đorđević Radiša ; Balkaya Ahmet ; Damnjanović Jelena ; Đorđević Mladen ; Vujošević Ana Journal: Genetika Year: 2011 Vol: 43 Issue: 2 Pages/record No.: 209-216

Effect of organic fertilizers in yield of pepper crop (Capsicum annuum L.), and characteristics of soil chemical of the experimental plot
Author: Fernando Ramos Gourcy ; Juan Antonio Aguilar Rubalcava ; Mario Alejandro López Gutiérrez ; Yisa María Ochoa Fuentes ; Otilio Vázquez Martínez Journal: Investigación y Ciencia de la Universidad Autónoma de Aguascalientes Year: 2011 Vol: Issue: 51 Pages/record No.: 3-9

Flowering, Growth and Fruit Setting in Greenhouse Bell Pepper under Water Stress
Author: A. Ferrara ; S. Lovelli ; T. Di Tommaso ; M. Perniola Journal: Journal of Agronomy Year: 2011 Vol: 10 Issue: 1 Pages/record No.: 12-19

Yield Traits and Water and Nitrogen Use Efficiencies of Bell Pepper Grown in Plastic-Greenhouse
Author: Vincenzo Candido ; Vito Miccolis ; Anna Rita Rivelli Journal: Italian Journal of Agronomy Year: 2011 Vol: 4 Issue: 3 Pages/record No.: 91-100

Influencia del régimen térmico en el desarrollo foliar del pimiento (Capsicum annuum L.) cultivado en campo
Author: Vidal, J.L. ; Budeguer, R. ; Alderete, G. ; Romero, E. ; Rodríguez Rey, J. ; Amado, M.E. ; Bas Nas, S. Journal: Horticultura Argentina Year: 2010 Vol: 29 Issue: 69 Pages/record No.: 13-17

EFECTOS HETERÓTICOS Y APTITUD COMBINATORIA EN POBLACIONES DE CHILE DULCE (Capsicum annuum L.)
Author: Anastacio M. Pech May ; Guillermo Castañón Nájera ; José M. Tun Suárez ; Mariano Mendoza Elos ; Javier O. Mijangos Cortés ; Alfonzo Pérez Gutiérrez ; Luis Latournerie Moreno Journal: Revista Fitotecnia Mexicana Year: 2010 Vol: 33 Issue: 4 Pages/record No.: 353-360

The Drying Kinetics of Chilies using a Rotating Fluidized Bed Technique
Author: Kittichai Triratanasirichai ; Worachest Pirompugd ; Watcharin Dongbang Journal: American Journal of Applied Sciences Year: 2010 Vol: 7 Issue: 12 Pages/record No.: 1599-1606

ATRIBUTOS DE CALIDAD Y VIDA DE ANAQUEL DE FRUTOS DE CULTIVARES DE CHILE SERRANO EN MÉXICO
Author: Enrique Vázquez García ; Moisés Ramírez Meraz ; Horacio Mata Vázquez ; Rafael Ariza Flores ; Irán Alia Tejacal Journal: Revista Fitotecnia Mexicana Year: 2010 Vol: 33 Issue: 4 Pages/record No.: 79-82

Diallel Analysis using Hayman Method to Study Genetic Parameters of Yield Components in Pepper(Capsicum annuum L.)
Author: MUHAMAD SYUKUR ; SRIANI SUJIPRIHATI ; RAHMI YUNIANTI ; UNDANG Journal: HAYATI Journal of Biosciences Year: 2010 Vol: 17 Issue: 4 Pages/record No.: 183-188

Influence of Deficit Irrigation on Water Use Efficiency and Bird Pepper Production (Capsicum annuum L.) تأثير معدل العجز في كمية مياه الري المضافة على كفاءة استخدام المياه وإنتاج الفلفل الحار (Capsicum annuum L.)
Author: Saleh Ismail Journal: Journal of King Abdulaziz University : Meteorology, Environment and Arid Land Agriculture Sciences Year: 2010 Vol: 21 Issue: 2 Pages/record No.: 29-43

A PCR-Based Method to Detect Alpha Thalassemia With South East Asia Mutation

2011-11-11T21:54:00.000-08:00

A PCR-Based Method to Detect Alpha Thalassemia With South East Asia Mutation

By Ayman A. Al-Qaddome, BSc.MSc.

Abstract

Objective : The currently tehcniques in ordinary hematology laboratories do not allow for definitive dignosis of alpha thalassemia carrier status.

Key words : Polymerase chain reaction, Alpha thalassemia, South East Asia mutation

For download full article, pleas visit this link : http://www.jrms.gov.jo/Portals/1/Journal/2005/pdf%20dec2005/A%20PCR-BASED%20METHOD%20TO%20DETECT%20ALPHA%20THALASSEMIA%20WITH%20SOUTH%20EA.pdf

Preliminary Study on Thalassemia Screening and Genetic Counseling in Selective Hmong People in Saraburi Province, Thailand

2011-11-11T21:44:00.000-08:00

Preliminary Study on Thalassemia Screening and Genetic Counseling in Selective Hmong People in Saraburi Province, Thailand
By
Pa Vang, RN, RCS, BSN
Onuma Zongrum, M.Sc
Ratana Sindhuphak, PhD
Nikorn Dusitsin, MD
Institute of Health Research (IHR), Chulalongkorn University
Hmong Studies Journal, Volume 8, 19 Pages

ABSTRACT

Thalassemia is a gene-linked disease that can cause serious health problems because it can lead to the destruction of red blood cells. Studies have shown that there is a high prevalence of thalassemia in Southeast Asia. The Institute of Health Research, Chulalongkorn University developed a successful “Module” to screen for thalassemia in the Thai population, however, it has not been implemented in the minority population in Thailand. In this study, we investigated the feasibility of the newly developed educational and thalassemia screening program with the Hmong population. The primary aim of this study was to test this program. The secondary aim was to determine the prevalence of thalassemia in the Hmong and provide education. A third aim was to determine the reliability of two different screening methods in the Hmong population. A pre-test and post-test design was used; participants (N=12) were individuals residing in Thailand with the ability to read English and between the ages 18-50. The participants met twice with the researchers to complete the program. The first contact consisted of assessing participants’ knowledge about thalassemia, providing thalassemia information and education about genetic counseling, and drawing blood samples. The second contact consisted of assessing knowledge, providing a written report of individual blood sample results and counseling. The initial interview revealed that the majority of the participants (82%) did not know anything about thalassemia prior to participation. The program was easy to understand by most participants (90%). Of the eleven Hmong participants, two tested positive for being a possible carrier for thalassemia. In order to reduce the prevalence of thalassemia, it is necessary to engage in risk reduction health services. The modified screening method proved to be as effective as the standard method. Therefore, the program can expand and be used in other regional populations with low cost.

Keyword : Thalasemia disease

for download full article. Please visit this link : http://www.hmongstudies.org/VangZongrumSindhuphakDusitsinHSJ8.pdf

Bioadhesive-floating matrix tablet of salbutamol sulphate using response surface methodology: optimization and in vitro evaluation

2011-11-11T21:30:00.000-08:00

Bioadhesive-floating matrix tablet of salbutamol sulphate using
response surface methodology:
optimization and in vitro evaluation
Girish S. Sonar*, M. R. P. Rao, R. R. Mandsaurwale, Vishal K. Gogad, Swapnila D. Vanshiv.
AISSMS College of Pharmacy, Department of Pharmaceutics, Kennedy Road, Near RTO, Pune - 411 001, India.
Received on: 12-09-2008; Accepted on: 05-03-2009

ABSTRACT

The purpose of this research was to develop and optimize Bioadhesive-Floating Drug Delivery system (BFDDS) for salbutamol sulphate, which is absorbed from the upper part of GIT. A 23 full factorial design was applied to systematically optimize the drug release profile and bioadhesive force, with total polymer-to-drug ratio (X1), polymer-to-polymer (X2) and polymer grade (X3) as independent variables. The percentage drug release after 8 h, time required for 50 % drug dissolution (t50%) and bioadhesive force (f) were kept as dependent variables. Hydroxypropyl methyl cellulose (HPMC) of different viscosity grades and Carbopol 940P (CP940) were used in formulating the gastroretentive bioadhesive-floating drug delivery system. Response surface plots were drawn, and optimum formulations were selected by grid search method. Regression analysis and numerical optimization were preformed to identify the best formulation. It was found that HPMC, Carbopol and their interaction had significant impact on the release and bioadhesive properties of the delivery system. The decrease in the release rate was observed with an increase in the viscosity of the polymeric system but at higher concentration HPMC; different grades of HPMC (K4M and K100M CR) did not significantly affect the release profile. Kinetic treatment of dissolution profiles revealed that drug release ranges from anomalous transport to super case (II) type. The observed difference in the drug release and the bioadhesive properties of BFDDS could be attributed to the difference in the basic properties of three polymers (HPMC K4M, K100M CR and CP940) due to their water uptake potential and functional group substitution. The predicted values agreed well with the experimental values, and the results demonstrate the feasibility of the model in the development of bioadhesive-floating drug delivery system.

Keywords: Salbutamol sulphate, bioadhesive-floating, ex-vivo bioadhesive studies, response surface methodology

For download full article please visit this link : http://jpronline.info/article/download/344/300

Formulation and evaluation of effervescent floating tablet of Levofloxacin against H.pylori infection

2011-11-11T21:24:00.000-08:00

Formulation and evaluation of effervescent floating tablet of
Levofloxacin against H.pylori infection
Shreeraj H. Shaha*, Jayvadan K. Patelb, Nirav V. Patelc
aL.J. Institute of Pharmacy, Gujarat University, Ahmedabad, Gujarat, India
bNootan Pharmacy College, North Gujarat Hemchandracharya University, Visnagar, North
Gujarat, India
cAnand College of Pharmacy, S.P. University, Anand, Gujarat, India

______________________________________________________________________________
ABSTRACT

The purpose of the present study was to develop a gastric floating drug delivery system (GFDDS)
containing Levofloxacin against the H.pylori infection using gas-forming agents, like sodium
bicarbonate, citric acid and hydrocolloids, like Hydroxypropyl ethylcellulose (HPMC) and Carbopol
974P. The prepared tablets were evaluated in terms of their pre compression parameters, physical
characteristics, in vitro release, buoyancy, floating lag time (FLT), total floating time (TFT) and swelling
index. The formulations were optimized for the different viscosity grades of HPMC, Carbopol 974P and
its concentrations and combinations. Stability study was also performed after storage at 40°C/75% RH
for three months. All the formulations showed good floating lag time i.e. less than 3 mins. The batch
containing combination of HPMC K4M, HPMC K100M and Carbopol 974P (i.e. L12) showed total
floating lag time more than 24 hrs. The batch L12 showed the highest swelling index among all the
prepared batches (i.e. 95%). The batch L12 was chosen as the optimized batch since it was also stable for
three months during stability study.

Keywords: gastric floating drug delivery system, total floating time, HPMC, Carbopol 974P,
stability study.
______________________________________________________________________________

For full article, please visit this link http://www.ijppsjournal.com/Vol2Issue1/234.pdf

Formulation And Evaluation Of Sustained Release Matrix Tablets Containing Metformin Hcl And Syzygium cumini

2011-11-11T21:20:00.000-08:00

www.ijpba.info. International Journal of Pharmaceutical & Biological Archives 2011; 2(3):900-905

Formulation And Evaluation Of Sustained Release Matrix Tablets Containing Metformin Hcl And Syzygium cumini
N.Aruna1*, M.Kishore Babu2
1 Bapatla College of Pharmacy, Bapatla, Andhra Pradesh 2 Associate Professor,Department of Pharmaceutics, Bapatla College of Pharmacy, Bapatla, Andhra Pradesh, India.
Received 02 May 2011; Revised 04 Jun 2011; Accepted 17 Jun 2011

ABSTRACT
The purpose of the research work is to formulate and evaluate Metformin HCl sustained release matrix tablet using Syzygium cumini as a release rate retarding agent which is also antidiabetic in nature by means of wet granulation method. The influence of the release rate by different diluents was studied. Further the optimization of release rate of the drug was carried out by using various polymers such as HPMC K100M, Eudragit RLPO, Carbopol940, Ethyl cellulose. Tablets thus formulated were evaluated for various physical tests like weight variation, hardness, friability and results complied with in the limits. The drug release from all the formulations followed zero order kinetics and Korsmeyer-Peppas mechanism with n value > 0.5 indicating the drug released by non fickian diffusion mechanism. Formulation F6 containing HPMC K 100 M and Ethylcellulose showed the sustained drug release pattern upto 12 hrs which matched the drug release pattern of innovator. The antidiabetic activity of a formulation was evaluated with alloxan model of experimental rats. The results suggested that the syzygium cumini extract acted as a good release rate retarding agent and also showed promising additive antidiabetic activity with Metformin HCl.

Key words: Metformin HCl, Syzygium cumini, sustained matrix tablets, additive, antidiabetic activity.

For download full article, please visit : http://ijpba.info/ijpba/index.php/ijpba/article/download/285/204

BOTANI EKONOMI SUKU ZINGIBERACEAE SEBAGAI OBAT TRADISIONAL OLEH MASYARAKAT DI KOTAMADYA BANJARBARU

2011-08-30T22:48:00.000-07:00

Evi Mintowati Kuntorini
Program Studi Biologi
Fakultas MIPA Universitas Lambung Mangkurat
Jl. A. Yani Km 35,8 Banjarbaru, Kalimantan Selatan

ABSTRAK

Penelitian mengenai etnobotani suku Zingiberaceae sebagai obat tradisional pada berbagai golongan etnis di Kodya Banjarbaru bertujuan untuk mengkaji tingkat pengetahuan dan pemanfaatan suku Zingiberaceae sebagai obat tradisional. Hasil penelitian menunjukkan bahwa tujuh jenis anggota suku Zingiberacea digunakan dalam pengobatan tradisional, yaitu Alpinia galanga, Curcuma domestica, Curcuma xanthorrhiza, Kaempferia galanga, Zingiber officinale, Kaempferia pandurata, dan Curcuma aeruginosa. Tingkat pemanfaatan suku Zingiberaceae dari hasil penelitian belum merata untuk tiap jenisnya yaitu dengan melihat dari Indeks Nilai Penting (INP). Empat jenis dari suku Zingiberaceae (Lengkuas, Temulawak, Temu ireng dan Temu kunci) penggunaan tanaman tersebut masih dibawah 20 % dari jumlah responden untuk tiap etnis maupun pada tiap lokasi kecamatan, sedangkan tingkat pemanfaatan tanaman kunyit dan jahe memiliki INP = 6 (tingkat penggunaannya diatas 20 % pada ketiga lokasi kecamatan dan digunakan oleh ketiga kelompok etnis). Kaempferia galanga memiliki INP = 3 untuk pengobatan jenis penyakit gangguan pernapasan, Zingiber officinale INP = 3 untuk pengobatan demam, adapun Curcuma xanthorrhiza memiliki INP = 3 untuk pengobatan jenis penyakit dalam dan menetralkan darah.
Kata kunci : etnobotani, Zingiberaceae, obat tradisional

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PROSPEK TANAMAN NILAM PENGHASIL MINYAK ATSIRI : PENGEMBANGANNYA MELALUI SISTIM POLA TANAM

2011-08-29T05:46:00.000-07:00

Sukamto
Balai Penelitian Tanaman Obat dan Aromatik
Jl. Tentara Pelajar No. 3, Bogor 16111
(Terima tgl. 17/7/2009 - Disetujui tgl. 20/11/2009)

ABSTRAK

Minyak esensial merupakan campuran kompleks dari senyawa yang mudah menguap, dan dihasilkan sebagai metabolit sekunder pada tumbuhan. Minyak esensial biasa menentukan untuk aroma khas tana-man. Sampai saat ini telah dikenal kira-kira 3.000 jenis minyak atsiri dan 10% dari jumlah tersebut telah dikomersialkan sebagai bahan kosmetik, makanan, dan farmasi. Sebagian besar minyak atsiri Indonesia diusa-hakan oleh petani untuk keperluan ekspor maupun kebutuhan dalam negeri. Selain budidaya dan penanganan pasca panen, masalah utama minyak atsiri khususnya nilam adalah harga yang sering berfluktuasi. Pemasaran minyak atsiri tidak begitu mudah, di pasaran internasional seringkali telah diikat oleh berbagai jaringan pemasaran atau sindikat, sehingga eksportir baru tidak mudah masuk ke pasaran internasional. Harga minyak atsiri khususnya minyak nilam sangat berfluktuasi dari waktu ke waktu. Hal ini menyebabkan banyak petani yang melakukan diversifikasi atau menggunakan pola tanam tumpangsari dalam budidaya minyak atsiri. Pengembangan budidaya beberapa tanaman atsiri berpeluang dilakukan dengan menerapkan pola tumpangsari atau tanaman campuran baik dengan tanaman semusim maupun tahunan.
Kata Kunci : Minyak atsiri, nilam, pola tanam

ABSTRACT

Prospects of Patchouli to Produce Essential Oil; Development through Cropping Pattern System
Essential oils are complex mixtures of volatile organic com-pound produced as secondary metabolites in plants. Essential oils are usually responsible for the distinctive odor of plants. Approximately 3,000 essential oils have been known and 10% of them have commercial importance in the cosmetics, food, and pharmaceutical industries. Most of the essential oils cultivated by farmers in Indonesia are export oriented and for domestic demand. Besides cultivation and post harvest handling, other important problem, especially for patchouli oil, is frequently price fluctuation. Marketing of essential oils is not easy, especially in the inter-national market, it often has been linked by a variety of marketing network or trading unions, so new exporters are not easy to enter the international market. Essential oil (especially patchouli oil) prices fluctuate from time to time. This causes many farmers to apply crop diversification or rotation system in essential oil plant cultivation. Cultivation development of some important crops such as patchouli oil is done by applying the cropping pattern system (mixed cropping, inter cropping, multiple cropping, alley cropping) with annual or seasonal crops.
Keyword : Essential oil, Pogostemon cablin, cropping pattern

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PENGARUH EKSTRAK ADAS 50% TERHADAP PROSES PENYEMBUHAN LUKA

2011-08-29T02:41:00.000-07:00

ADISTY RESTU POETRI
Fakultas Kedokteran Gigi Universitas Gadjah Mada Yogyakarta

ABSTRACT

Background: Tissue injury causes the disruption of blood vessels and extravasation of blood constituents. Localized vasodilatation, increased vascular permeability, extravasation of plasma (and humoral) proteins, and migration of leukocytes into the affected tissue produce the classic signs of inflammation: calor, dolor, rubor, tumor, and functio laesa. Collagen is the major protein component of the connective tissue of vertebrates. Foeniculum vulgare Mill belongs to the Family Apiaceae (former Umbelliferae). F. vulgare is claimed to have an effect in relieving inflammation. In an in vivo study with mice, oral administration of Foeniculum vulgare fruit methanolic extract exhibited inhibitory effects against acute and subacute inflammatory diseases and type IV allergic reactions and showed a central analgesic effect. The aim of this practicum is to observed density of collagen fiber in wound healing after it given by topical extract herbal. Methods and results: Students observed control slides and adas extract slides in the 1st, 3rd, 5th, 7th, 10th and 14th days by microscope in 10 viewfield. Student gave score for every density of collagen fiber and the results of practicum is density collagen adas extract slides increased from the 1st day until th 3rd day and decreased from the 5th day until the 10th day but it the last day it increased. Conclusion: Extract adas 50% increasing density collagen and proliferate vascular so it makes wound healing faster.

Keywords: Inflammation, collagen, Foeniculum vulgare Mill

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Antimicrobial and Cytotoxic Activities of Zingiber officinalis Extracts

2011-08-28T22:28:00.000-07:00

Antimicrobial and Cytotoxic Activities of Zingiber officinalis Extracts
Ayşe NALBANTSOY*°, Duygu AYYILDIZ TAMİŞ*, I. Hakkı AKGÜN*, Tansel ÖZTÜRK YALÇIN*,
İsmet DELILOĞLU GÜRHAN*, İsmail KARABOZ**

Antimicrobial and Cytotoxic Activities of Zingiber officinalis Extracts

Summary

In the present study, the edible plant Zingiber officinalis ethanol and chloroform extracts were prepared and their cytotoxic effects versus human cervical cancer (HeLa) and mouse fibroblast (L929) cell-lines were investigated. HeLa and L929 cell lines in 96 well microplates were cultivated for 24 h with initial concentrations of 8×04 cells/mL and 7.4×104 cells/mL, respectively. After that the cultures were treated with different dilutions of the extracts and incubated for 48 h. The growth inhibition was determined to the 50% inhibition concentration (IC50). IC50 values were reported as ±95 % confidence intervals (±95 % CI) by using Graph Pad Prism (San Diego, CA). The antibacterial activity of the ginger extracts was tested by the paper disc diffusion technique. The results of the morphological observation and MTT test indicated that the cytotoxic activity of the extracts were dose dependent. IC50 values versus L929 and HeLa cells were found to be 87.28 μg/mL and 74.32 μg/mL, respectively, for the chloroform extract, while the ethanol extract showed IC50 values at 101 μg/mL and 33.78 μg/mL, respectively. Moreover, the extracts were evaluated for their antimicrobial
activities against Klebsiella pneumoniae, Salmonella thyphimurium, Bacillus cereus, Enterococcus fecalis and Staphylococcus aureus. The antimicrobial activity results showed that the ginger extracts inhibited the growth of five out of eight microorganisms but had no effect on the growth of Escherichia coli ATCC11230, Pseudomonas aeruginosa ATCC 27853, and Staphylococcus epidermidis ATCC 12228.

Keywords: Zingiber officinalis, HeLa, L929, anticancer effect, antimicrobial activity.

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Activities of Ten Essential Oils towards Propionibacterium acnes and PC-3, A-549 and MCF-7 Cancer Cells

2011-08-28T20:37:00.000-07:00

Yuangang Zu 1,2,†, Huimin Yu 3,†, Lu Liang 1,2, Yujie Fu 1,2,*, Thomas Efferth 4, Xia Liu 1,2 and Nan Wu 1,2
1 Key Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University, Harbin 150040, China; E-Mails: zygorl@vip.hl.cn (Y.Z.); luliang20100224@yahoo.com.cn (L.L.); lx20030135@yahoo.com.cn (X.L.); bao_doubao@yahoo.com.cn (N.W.)
2 Engineering Research Center of Forest Bio-preparation, Ministry of Education, Northeast Forestry University, Harbin 150040, China
3 Chinese Medicine Department, The Second Hospital of Harbin Medical University, Harbin 150086, China; E-Mail: huimin1973@126.com (H.Y.)
4 Department of Pharmaceutical Biology, Institute of Pharmacy, University of Mainz, 55099 Mainz, Germany; E-Mail: t.efferth@dkfz.de (T.E.)
† These authors contributed equally to this work.
* Author to whom correspondence should be addressed; E-Mail: yujie_fu2002@yahoo.com; Fax: +86-451-82190535.

Abstract :

Ten essential oils, namely, mint (Mentha spicata L., Lamiaceae), ginger (Zingiber officinale Rosc., Zingiberaceae), lemon (Citrus limon Burm.f., Rutaceae), grapefruit (Citrus paradisi Macf., Rutaceae), jasmine (Jasminum grandiflora L., Oleaceae), lavender (Mill., Lamiaceae), chamomile (Matricaria chamomilla L., Compositae), thyme (Thymus vulgaris L., Lamiaceae), rose (Rosa damascena Mill., Rosaceae) and cinnamon (Cinnamomum zeylanicum N. Lauraceae) were tested for their antibacterial activities towards Propionibacterium acnes and in vitro toxicology against three human cancer cell lines. Thyme, cinnamon and rose essential oils exhibited the best antibacterial activities towards P. acnes, with inhibition diameters of 40 ± 1.2 mm, 33.5 ± 1.5 mm and 16.5 ± 0.7 mm, and minimal inhibitory concentrations of 0.016% (v/v), 0.016% (v/v) and 0.031% (v/v), respectively. Time-kill dynamic procedures showed that thyme, cinnamon, rose, and lavender essential oils exhibited the strongest bactericidal activities at a concentration of 0.25% (v/v), and P. acnes was completely killed after 5 min. The thyme essential oil exhibited the strongest cytotoxicity towards three human cancer cells. Its inhibition concentration 50% (IC50) values on PC-3, A549 and MCF-7 tumor cell lines were 0.010% (v/v), 0.011% (v/v) and 0.030% (v/v), respectively. The cytotoxicity of 10 essential oils on human prostate carcinoma cell (PC-3) was significantly stronger than on human lung carcinoma (A549) and human breast cancer (MCF-7) cell lines.

Keywords: essential oils; activities; Propionibacterium acnes; cytotoxicity; cancer cell lines

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Effects of Zingiber officinale on Superoxide Dismutase, Glutathione Peroxidase, Catalase, Glutathione and Malondialdehyde Content in HepG2 Cell Line

2011-08-28T02:31:00.000-07:00

Harliansyah Abdul Hanif, Noor Azian Murad1, Wan Zurinah Wan Ngah and
Yasmin Anum Mohd Yusof
Department of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Raja Muda
Abdul Aziz, 50300 Kuala Lumpur, Malaysia. 1Centre of Lipids and Engineering and Applied Research,
University Technology of Malaysia, Kuala Lumpur

Abstract

Ginger (Zingiber officinale) is one of the most heavily consumed dietary substances in the world. Some studies have shown that ginger may possess antioxidant and antitumor properties. The objective of this study is to measure activities of superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT), glutathione (GSH) and malondialdehyde (MDA) content in human liver cancer cell line (HepG2) and normal liver cell line (WRL-68) treated with Zingiber officinale extract. HepG2 and WRL-68 cell lines were grown in Eagle Minimum Essential Medium of Earle (EMEM) supplemented with 10% fetal calf serum and incubated at 37°C with 5% CO2. Activities of SOD, GPx, CAT, and GSH and MDA contents were measured spectrophotometrically. The results of this study showed that in untreated cultures, high SOD (2 fold higher than normal) activity was found in HepG2 cell line when compared to normal cell line. There were no significant differences in GPx and CAT activities, GSH and MDA contents between the untreated liver cancer and normal cell lines. Ginger extracts at 500 μg/ml, reduced SOD activity significantly by 72.32% in HepG2 cell line when compared to untreated cell lines. Ginger extract also reduced significantly GPx activities by 77.16 %, 87.35 % and 71.05 % in HepG2 cell line at 100, 200 and 500 μg/ml respectively, when compared to untreated culture. Ginger extracts at 200 and 500 μg/ml reduced catalase activities by 41.65 and 67.43 % in HepG2 cell line when compared to untreated culture respectively. Ginger extract had no effect on glutathione and MDA contents in normal (WRL-68) and in liver cancer (HepG2) cell lines at all concentration. This study showed that Zingiber officinale extract may exert its anticancer effect by replacing the function of SOD, GPx and catalase in removing superoxide radicals and hydrogen peroxide that cause oxidative damage to cells.

Keywords: antioxidant, anticancer, Zingiber officinale, HepG2, free radicals

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Protective effect of ginger (Zingiber officinale) on adriamycin - induced hepatotoxicity in albino rats

2011-08-27T23:21:00.000-07:00

Saber A. Sakr1, Hoda A. Mahran1 and Hawazen A. Lamfon2
1Department of Zoology, Faculty of Science, Menoufia University, Egypt.
2Department of Biology, Faculty of Applied Sciences, Umm Al-Qura University, Saudi Arabia.

Abstract

The effect of ginger (Zingiber officinale) upon hepatotoxicity induced in albino rats by the anticancer drug, adriamycin (ADR) was studied. Animals were divided into four groups. The first group was injected intraperitonealy with ADR at a dose level of 2 mg/kg body weight in sterile saline, once per week for 6 weeks. The second group was treated with ADR at the same dose level as those of group 1 followed by oral administration of 1 ml of final aqueous extract of ginger (24mg/ml) 3 times weekly for 6 weeks. Animals in third group were given ginger only and those in the fourth group were served as normal controls. Injecting animals with ADR induced various histological changes in the liver. These changes include congestion of blood vessels, leucocytic infiltration, cytoplasmic vacuolization of the
hepatocytes and fatty infiltration. Adriamycin caused significant elevation in serum ALT (Alanine aminotransferase) and AST (Aspartate aminotransferase) enzymes after 4 and 6 weeks of treatment. It also caused an increase in malondialdehyde (lipid peroxidation marker) and depletion of the antoxidant enzyme, superoxide dismutase. Treating animals with water extract of ginger and adriamycin led to an improvement in the histological changes induced by adriamycin together with significant decrease in ALT and AST activity. Moreover, ginger reduced the level of malondialdehyde and increased the activity of superoxide dismutase. The results of the present work indicated that ginger had protective effect against liver damage induced by adriamycin and this is due to its antioxidant activities.

Key words: Ginger, adriamycin, liver, histology, transaminases.

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