Life Science Alliance | Cell Biology http://www.life-science-alliance.org/cellbiology Mon, 22 Aug 2022 23:34:30 GMT Feed43 Proxy/1.0 (www.feed43.com) 360 6e46958dbcd3e88bfbc3c16dc350563b Mon, 22 Aug 2022 23:34:30 GMT The cation exchanger Letm1, circadian rhythms, and NAD(H) levels interconnect in diurnal zebrafish https://www.life-science-alliance.org/content/5/9/e202101194 The cation exchanger Letm1, circadian rhythms, and NAD(H) levels interconnect in diurnal zebrafish Pauline Dao, Stefan Hajny, Ronald Mekis, Lukas Orel, Nora Dinhopl, Kristin Tessmar-Raible, Karin Nowikovsky

The mitochondrial osmoregulator Letm1 exhibits a diel regulation, impacts on NAD+/H levels, circadian genes, and its study allows new perspectives on possible genetic compensation mechanisms.

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]]> cd39ccb3eed24b6bb29aba18ebee381d Sun, 10 Jul 2022 18:03:41 GMT LncRNA RUS shapes the gene expression program towards neurogenesis https://www.life-science-alliance.org/content/5/10/e202201504 LncRNA <em>RUS</em> shapes the gene expression program towards neurogenesis Marius F Schneider, Veronika Müller, Stephan A Müller, Stefan F Lichtenthaler, Peter B Becker, Johanna C Scheuermann

The chromatin-associated lncRNA RUS binds in the vicinity to neural differentiation-associated genes and regulates them in a context-dependent manner to enable proper neuron development.

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]]> 6e94cb67caf27bbffd14b5964ebf2799 Sun, 10 Jul 2022 18:03:40 GMT ERK-Smurf1-RhoA signaling is critical for TGFβ-drived EMT and tumor metastasis https://www.life-science-alliance.org/content/5/10/e202101330 ERK-Smurf1-RhoA signaling is critical for TGFβ-drived EMT and tumor metastasis Jianzhong Zheng, Zhiyuan Shi, Pengbo Yang, Yue Zhao, Wenbin Tang, Shaopei Ye, Zuodong Xuan, Chen Chen, Chen Shao, Qingang Wu, Huimin Sun

The research uncovers a non-canonical role of ERK in TGF-beta-induced EMT, revealing ERK-mediated phosphorylation of Smurf1 is required for its sufficient binding to RhoA and the subsequent RhoA turnover.

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]]> c194f21a958a072a729de56f5da7d1cb Sun, 10 Jul 2022 18:03:39 GMT VDAC1 negatively regulates melanogenesis through the Ca2+-calcineurin-CRTC1-MITF pathway https://www.life-science-alliance.org/content/5/10/e202101350 VDAC1 negatively regulates melanogenesis through the Ca<sup>2+</sup>-calcineurin-CRTC1-MITF pathway Jianli Wang, Juanjuan Gong, Qiaochu Wang, Tieshan Tang, Wei Li

This study revealed an important and novel role of mitochondrial VDAC1 in regulating melanogenesis in resting melanocytes through a Ca2+-regulated pathway that is independent of the alpha-MSH/UVB pathway.

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]]> c7fa7f429061d3f81d113211d0998947 Sun, 10 Jul 2022 18:03:38 GMT Axonal transport of Hrs is activity dependent and facilitates synaptic vesicle protein degradation https://www.life-science-alliance.org/content/5/10/e202000745 Axonal transport of Hrs is activity dependent and facilitates synaptic vesicle protein degradation Veronica Birdsall, Konner Kirwan, Mei Zhu, Yuuta Imoto, Scott M Wilson, Shigeki Watanabe, Clarissa L Waites

This study describes an activity-dependent mechanism for transporting ESCRT-0 protein Hrs to synaptic vesicle (SV) pools, facilitating SV protein degradation in response to increased neuronal firing.

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]]> 726ac0700de69147330c49c56ae504c5 Sun, 10 Jul 2022 18:03:37 GMT Lack of Hikeshi activates HSF1 activity under normal conditions and disturbs the heat-shock response https://www.life-science-alliance.org/content/5/9/e202101241 Lack of Hikeshi activates HSF1 activity under normal conditions and disturbs the heat-shock response Shingo Kose, Kenichiro Imai, Ai Watanabe, Akira Nakai, Yutaka Suzuki, Naoko Imamoto

Hikeshi mediates proper nucleocytoplasmic distribution of HSP70, which is important for regulating of HSF1 activity and nuclear proteostasis, and adaptive response to heat shock.

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]]> 59a343c8e16810ed7bec4fea934294bf Sun, 10 Jul 2022 18:03:36 GMT DUSP4 protects BRAF- and NRAS-mutant melanoma from oncogene overdose through modulation of MITF https://www.life-science-alliance.org/content/5/9/e202101235 DUSP4 protects BRAF- and NRAS-mutant melanoma from oncogene overdose through modulation of MITF Nuria Gutierrez-Prat, Hedwig L Zuberer, Luca Mangano, Zahra Karimaddini, Luise Wolf, Stefka Tyanova, Lisa C Wellinger, Daniel Marbach, Vera Griesser, Piergiorgio Pettazzoni, James R Bischoff, Daniel Rohle, Chiara Palladino, Igor Vivanco

Our study demonstrates that in BRAF- and NRAS-mutant MITF-proficient melanoma, the DUSP4 MAPK phosphatase restricts MAPK activation and prevents oncogenic overdose through modulation of MITF function.

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]]> a6d5aaf603ab710f69a2998b6446f33c Sun, 10 Jul 2022 18:03:35 GMT The HDL particle composition determines its antitumor activity in pancreatic cancer https://www.life-science-alliance.org/content/5/9/e202101317 The HDL particle composition determines its antitumor activity in pancreatic cancer Raimund Oberle, Kristina Kührer, Tamina Österreicher, Florian Weber, Stefanie Steinbauer, Florian Udonta, Mark Wroblewski, Isabel Ben-Batalla, Ingrid Hassl, Jakob Körbelin, Matthias Unseld, Matti Jauhiainen, Birgit Plochberger, Clemens Röhrl, Markus Hengstschläger, Sonja Loges, Herbert Stangl

The authors show that particle composition–dependent, efficient HDL-mediated cholesterol depletion induces apoptosis and interferes with the aggressive growth characteristics of pancreatic cancer cells.

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]]> fdbffc20e10dbafce4aa836c2ce40698 Sun, 10 Jul 2022 18:03:34 GMT Nuclear ingression of cytoplasmic bodies accompanies a boost in autophagy https://www.life-science-alliance.org/content/5/9/e202101160 Nuclear ingression of cytoplasmic bodies accompanies a boost in autophagy Manon Garcia, Sylvain Kumanski, Alberto Elías-Villalobos, Chantal Cazevieille, Caroline Soulet, María Moriel-Carretero

We describe a fully new remodeling event of the nuclear envelope surrounding the nucleolus: it partitions into its regular contact with the vacuole and a dramatic internalization of globular cytoplasmic portions within the nucleus.

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]]> d31a86cc552c771105580a9e699babb9 Sun, 10 Jul 2022 18:03:33 GMT Plasmodium SAS4: basal body component of male cell which is dispensable for parasite transmission https://www.life-science-alliance.org/content/5/9/e202101329 <em>Plasmodium</em> SAS4: basal body component of male cell which is dispensable for parasite transmission Mohammad Zeeshan, Declan Brady, Robert Markus, Sue Vaughan, David Ferguson, Anthony A Holder, Rita Tewari

This work shows that Plasmodium SAS4 is a part of the basal body and outer centriolar MTOC but not essential for male gamete formation.

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