http://brigham1.botcodelocal.com Brigham and Women's Hospital RSS Jobs Null Null none Null General Overview This research position requires a highly trained research scholar in cellular and molecular immunology who can perform various immunological experiments ranging from in vitro cell culture assays to in vivo animal experiments. In detail, handling of knock-outs, reporters and transgenic animals, isolation of various cells populations from spleen and lymph nodes will be required. Incumbent will also be involved in measuring various cytokines by ELISA and real time PCR in an autoimmune model of MS. Moreover, experience in molecular biology techniques such as plasmid isolation, cloning, DNA and RNA purification, retroviral expression of various molecules is also required. In addition to performing the experiments, candidate must also have experience in analyzing and interpreting experimental data and preparing research manuscripts. Major Duties 1.Independently design and perform experiments.
2.Responsible for data generation, interpretation and communication.
3.Establish and maintain collaborative relationships with both internal and external research groups.
4.Obtain research funding to support independent projects.
5.Supervise research technicians and students Skills/Abilities/Competencies and#x2022;Expertise in immune regulation and autoimmune diseases.
and#x2022;Experience in EAE animal model
and#x2022;Cloning, and generation of transgenic mice Qualifications and#x2022;PhD in immunology with minimum of four years postdoctoral experience.
and#x2022;Substantial publication record
and#x2022;Proven ability to obtain research grants
EEO Statement: Brigham and Womenand#x2019;s Hospital (BWH) is internationally known as a leader in cutting-edge research and technology and its commitment to patient-centered care. BWH has a rich legacy of excellence and has been consistently recognized as one of Americaand#x2019;s best hospitals by US News and World Report. ]]> 7/19/2011 0.00 Null Null none Null General Overview Cutting edge projects focusing on the innate immune mechanisms leading to adaptive immunity. These projects include novel pathways that regulate macrophages, and T cells, macrophage biology linked to autoimmune disease, determining the unique and shared role of the principle macrophage developmental molecules in immune mediated inflammation, and the power of the programmed death pathway in regulating tissue injury. Furthermore, studies focus on tissue regenerative pathways mediated by resident cells and macrophages, and inflammation that fails to resolve and leads to disease. Unique transgenic strains and knockout mice with reporter genes have been constructed on autoimmune susceptible strains for these projects. These projects dissect the basic mechanisms of autoimmune disease (kidney, skin, heart) and have human translational components.

Experience:
Immunology, and/or Molecular biology and Cell Biology
Knowledge of histopathology desirable
Mouse systems
Computer literacy is necessary

Desired:
Responsible, hard-working individual who is able to multi-task and to work independently

MD, or PhD required, position for two years or longer within the Department of Medicine, Brigham and Womenand#x2019;s Hospital.

Please send three references.

Interested candidates contact: Dr. Vicki Rubin Kelley, Harvard Institutes of Medicine, 4 Blackfan Circle, Boston, MA 02115; FAX 617-525-5830; e-mail: vkelley@rics.bwh.harvard.edu

Brigham and Womenand#x2019;s Hospital is an EEO, AA and VEVRAA employer. ]]> 7/19/2011 0.00 Null Null none Null General Overview Postdoctoral position is available in a Cerebrovascular Research Laboratory to study the genetics and mechanisms of cerebral vasospasm, which occurs in the presence of subarachnoid hemorrhage. Major Duties 1. Designs experiments and interprets results.
2. Performs technical procedures such as immunohistochemistry, PCR, Wester blots, or other assays; prepares materials for microscopic examination.
3. Maintains mouse colonies and performs experiments in vivo, including microsurgery.
4. Harvests and prepares tissues from in vivo experiments for analysis.
5. Obtains, prepares and processes blood and tissue specimens from human subjects.
6. Prepares and maintains tissue and cell cultures.
7. Operates instruments and equipment such as cryotomes, centrifuges, incubators and fluorescent microscopes.
8. Operates ancillary equipment such as photographic equipment and computer equipment.
9. Manages and maintains database containing experimental results and reagent information and storage locations
10. Conducts literature reviews to assist in determining most suitable methods to be used in research.
11. Prepares and presents written or oral progress reports concerning studies, including assembly, organization and interpretation of data.
12. Performs statistical analysis of data.
13. Prepares laboratory reagents, chemicals, instruments and equipment.
14. Orders chemicals, reagents and other laboratory supplies.
15. Performs routine maintenance and minor repairs of laboratory apparatus and instruments.
16. Maintains a clean, orderly work area within the laboratory.
17. Undertakes standard decontamination procedures prior to disposal of certain laboratory materials.
18. Functions as the laboratory safety officer, responsible for compliance with all regulatory requirements, and the safe use of hazardous materials in the laboratory, including radioactive, biological and chemical agents.
19. May write computer programs.
20. May assist in supervising the work of other assigned laboratory personnel.
21. May demonstrate and explain various laboratory techniques to laboratory personnel, students and others.
22. Maintains established department policies, procedures and objectives, including the areas of quality assurance, safety, environmental and infection control.
23. Performs all other duties and responsibilities as directed.
EEO Statement: Brigham and Womenand#x2019;s Hospital is an EEO, AA and VEVRAA employer. Other Information Contact Information
Rose Du, MD, PhD
Department of Neurosurgery
Brigham and Womenand#x2019;s Hospital
Harvard Medical School
75 Francis Street
Boston, MA 02115
rdu@partners.org ]]> 7/19/2011 0.00 Null Null none Null General Overview We are looking to recruit a highly motivated postdoctoral research fellow to join a Advanced Endoscopy and bariatric research group. Dr. Christopher C. Thompsonand#x2019;s Laboratory is part of the Division of Gastroenterology, Hepatology and Endoscopy at Brigham and Womenand#x2019;s Hospital/Harvard Medical School. The focus of the research will be on the development of new endoscopic approaches for the treatment of GI and pancreatobiliary disorders and obesity. Projects might include device trials in ex vivo and rodent models, analysis of obesity related databases, translation of techniques into large animals and humans. In addition, the project will involve the integration of results with clinical studies aiming to address weight regain in the post-bypass patient or primary obesity therapies. This is a unique opportunity for working in a fast-paced, and highly collaborative, developmental and translational research group working at the interface of clinical investigation, biology, and therapeutic development. Major Duties 1. Working closely with basic science and clinical collaborators to design and execute experiments with human clinical specimens and model organisms.
2. Independently performs experiments which are moderate to complex.
3. Maintain rodent colonies.
4. Coordinates schedules of tests and procedures.
5. Record data, summarizes, and analyzes results using basic statistics.
6. Prepares laboratory reagents, chemicals, instruments, and equipment.
7. Maintains supplies inventory in accordance with laboratory procedures.
8. Discusses progress of work regularly with supervisor.
9. Calculate, transcribes and analyzes data using advanced statistical techniques.
10. In collaboration with PI or Research Lab Manager, establishes new and modifies existing research techniques.
11. In collaboration with the PI and Research Lab Manger, writes grants for submission to institutional, society and/or federal funding opportunities.
12. All other duties as assigned. Skills/Abilities/Competencies and#x2022; Must have experience with rodent models.
and#x2022; Ability to work independently.
and#x2022; Must have basic surgical skills and understanding of rodent anatomy.
and#x2022; High degree of computer literacy.
and#x2022; Sound analytical and organizational skills.
and#x2022; Requires good oral and written communication skills.
and#x2022; Must be able to logically and effectively structure tasks and set priorities.
and#x2022; Ability to identify potential problems and trouble-shoot solutions.
and#x2022; Demonstrated ability to analyze data statistically and to logically present it. Qualifications - Ph.D., MD/Ph.D., or MD in Surgery, Gastroenterology, Internal Medicine, Endocrinology and/or Biology required. Engineering degrees will be considered.

- Experience with statistical and programming skills preferred.

- Demonstrated success in technical proficiency, scientific creativity, collaboration with others and independent thought.

- Must have at least 1 year of research with rodent models.

- Proven record of significant contributions to research projects as individual contributor.

- Excellent communication skills
EEO Statement: Brigham and Womenand#x2019;s Hospital is an EEO, AA and VEVRAA employer. ]]> 7/19/2011 0.00 Null Null none Null General Overview The Personalized Cancer Medicine Partnership (PCMP) is a collaborative venture between two Harvard Medical School affiliated institutions- the Brigham and Women's Hospital and the Dana-Farber Cancer Institute. The mission of the PCMP is to advance translational and personalized cancer medicine by implementing tumor genomic profiling on all cancer patients treated at these institutions. PCMP will employ state-of-the art technology to generate a detailed profile of key andquot;druggableandquot; or otherwise andquot;actionableandquot; cancer genomic alterations in a CLIA-approved and andquot;real-timeandquot; process to facilitate rapid clinical application. These cancer genomic profiles with be used to guide patient treatment and/or stratification for clinical trials of novel anticancer agents.

This exceptional opportunity offers the chance to work at the forefront of discovery and translational cancer technologies and applications. We seek a Data Analyst to actively participate in data generation, analysis and reporting of genomic results (including sequencing and/or mass-spec genotyping). More specifically, he/she will have the following responsibilities, including but not limited to:

and#x2022;Incorporate existing algorithms for mutation detection in clinical samples and determine relevant performance characteristics
and#x2022;Generate semi-automated reports to aid with analysis and interpretation of genomic data
and#x2022;Coordinate mutation detection strategies with the bioinformatics and laboratory teams
and#x2022;Assist with genome analysis software implementation, including mutation detection and copy number analyses Qualifications and#x2022;MSc (PhD-preferred) with 2+ years experience working in laboratories with a concentration in genomics research or bioinformatic analyses of genomic data
and#x2022;Highly organized and self-directed individual, who works well in a complex and dynamic environment.
and#x2022;Ability to work closely and effectively with a diverse group of individuals from trainees to senior academic leaders in both clinical and scientific arenas.
and#x2022;Excellent computer, analytical and communication skills.

A minimum two-year commitment is required.
EEO Statement: Brigham and Womenand#x2019;s Hospital is an EEO, AA and VEVRAA employer. ]]> 7/19/2011 0.00 Null Null none Null
Responsibilities: GENERAL SUMMARY/ OVERVIEW STATEMENT
Radiation oncology clinical physicists are professionals primarily engaged in the evaluation, planning, delivery and optimization of radiation treatments. A primary responsibility is the accurate determination and specification of the radiation dosage for each treatment. The treatment planning functions include consultation with the clinician to design treatment plans, the preparation of the technical details for the deliveries, the correct implementation of the treatment plan, and the quality assurance and progress review of the treatment. Physicists with expertise in computer science applications will develop digital solutions to provide cost effective processes to integrate the above activities. At a more basic but critical level, clinical physicists develop and implement radiation dosimetry protocols and data bases for all radiation sources in the department (from machines, and sealed brachytherapy sources) to meet national and State standards. They report to the section chief or the Chief of Medical Physics.

PRINCIPAL DUTIES/ RESPONSIBILITIES
A. Patient Care:
1. Work along side with radiation oncologists to provide all the needed support for safe radiation treatments, including simulations, image processing, treatment plan designs and treatment deliveries to ensure correct radiation dosages and patient safety including decision to suspend treatments when necessary.
2. Participate and supervise all brachytherapy applications including dosimetric verification, treatment planning, documentation, and all radiation safety issues, including decision to stop treatments.
3. Implement special irradiation procedures, such as intensity modulated therapy, image guided radiation therapy, total body irradiation, stereotactic radiosurgery.
4. Participate in departmental chart reviews, experimental trials, national clinical protocols, and provide documentation to support these efforts.
5. Coordinate with other departments and integrate medical imaging information to assure patient care is seamless.

B. Clinical physics duties:
1. Develop and implement protocols for radiation dose specifications to meet national and state regulations.
2. Develop and maintain a State mandated Quality Management Program (QMP) covering external beam procedures and material license applications (brachytherapy and radiopharmaceuticals for therapy)
3. Develop and implement quality assurance programs and dosimetric verification procedures for patients undergoing treatments.
4. Design treatment facilities to meet the national and State radiation protection guidelines.
5. Assume key role in purchase acquisition, installation, and commissioning of all new machines and treatment planning systems.
6. Design computer programs to improve comprehensive analyses, processing and integration of imaging, planning and delivery information for maximum operational efficiency and accuracy. This is essential for image-guided and robotic techniques.
7. Work with engineers in the diagnosis, repair, maintenance, including assessment for release of treatment machines for clinical use.

C. Leadership and management responsibilities:
1. Assist in supervision, coaching, training of dosimetrists, junior physicists, and physics assistants, and other radiation therapy personnel.
2. Assist section chief in management of team effort.
3. Assist the hospital administration by assuming a key role in managing the technical aspects of clinical programs: implementation, quality assurance, documentation.
4. Apply quality improvement measures to enhance efficiency and safety of clinical programs.
5. Work closely with administration to provide accurate documentation for billing and charge capture to insure compliance.
6. Work with Administration on strategic and fiscal planning for on campus and outreach programs.

D. Teaching and Research and Development:
1. When appropriate, participate in the teaching of therapist students, post-doctoral fellows and clinical residents in radiation oncology.
2. When appropriate, participate in research and development projects under supervision and direction of faculty member.
Requirements: QUALIFICATIONS
A. Education:
At least a Masters Degree in Medical Physics

B. Experience:
At least 3 years of clinical experience in radiation oncology physics following the completion of the terminal Medical Physics degree. Evidence of the ability to act in a leadership/management role in his/her area of expertise. Computer programming experience is preferred.
Shift: Day Shift
EEO Statement: An EEO, AA, VEVRAA Employer ]]> 7/19/2011 0.00 Null Null none Null General Overview Under the supervision of the Principal Investigator, independently carries out and designs highly sophisticated and independent experiments. Will work in laboratory space dedicated to principal investigator with additional potential to establish successful project-specific collaborations in a variety-of directions. Major Duties 1. Researches, develops, designs, executes and interprets research experiments.
2. Contributes to scientific literature, reports, journals and presentations.
3. Investigates, creates and develops new methods and technologies for research advancement. Skills/Abilities/Competencies and#x2022; Strong research design and analytical skills.
and#x2022; Strong database statistical skills.
and#x2022; In-depth knowledge of field of research.
and#x2022; Excellent time management/organizational skills.
and#x2022; Strong written and verbal presentation skills. Qualifications The successful candidate will have recently completed graduate studies in an MD, PhD, or MD/PhD program with a strong research and publication record in the biological sciences.
EEO Statement: Brigham and Womenand#x2019;s Hospital is an EEO, AA and VEVRAA employer. ]]> 7/19/2011 0.00 Null Null none Null General Overview This research position requires a Senior Post-Doc or Instructor level candidate with a background in transplant immunology and publications in the field. The applicant should have experience in relevant in-vivo and in-vitro methods such as RT-PCR, FACS, cell-separation and -culture, immunohistochemistry, and immunoassays. In additional to performing experiments, the incumbent must also have experience in analyzing and interpreting experimental data and preparing research manuscripts and grants. Under the direction of the PI, the applicant will independently perform sophisticated experiments and will participate in the design of experimental protocols. Microsurgical experience is not a prerequisite but preferable.
Responsibilities: and#x2022;Responsible for data generation, interpretation and communication.
and#x2022;Micro Surgical experience preferred.
and#x2022;Establish and maintain collaborative relationships with both internal and external research groups.
and#x2022;Independently designs and executes experiments.
and#x2022;Obtain research funding to support independent projects. Skills/Abilities/Competencies and#x2022;Must be able to make independent, effective decisions.
and#x2022;Must possess a scientific imagination commensurate with the independent execution of research projects.
and#x2022;Demonstrated analytical skills and ability to logically sequence experiments to maximize research.
and#x2022;Must have aptitude for technical problem solving.
and#x2022;Should have experience in performing the following methods: isolation of immune cells from spleen, blood, kidney, and heart. Flow cytometry, mixed lymphocyte culture, ELISA, ELISPOT, immunohistochemistry, real time RT-PCR, Luminex. Qualifications and#x2022;PhD with minimum of two years postdoctoral experience.
and#x2022;Substantial publication record.
and#x2022;Micro Surgical experience preferred.
and#x2022;Proven ability to obtain research grants. Working Environment and#x2022;Normal laboratory environment.
and#x2022;May work with and/or be exposed to radioactive and other hazardous materials, under controlled conditions.
EEO Statement: Brigham and Womenand#x2019;s Hospital is an EEO, AA and VEVRAA employer. ]]> 7/19/2011 0.00 Null Null none Null General Overview Under the supervision of the Principal Investigator, independently carries out and designs highly sophisticated and independent experiments. Will work in laboratory space dedicated to principal investigator with additional potential to establish successful project-specific collaborations in a variety-of directions.
Responsibilities: 1.Researches, develops, designs, executes and interprets research experiments.
2.Contributes to scientific literature, reports, journals and presentations.
3.Investigates, creates and develops new methods and technologies for research advancement. Qualifications The successful candidate will have recently completed graduate studies in an MD, PhD, or MD/PhD program with a strong research and publication record in the biological sciences. Qualifications
EEO Statement: Brigham and Womenand#x2019;s Hospital is an EEO, AA and VEVRAA employer. ]]> 7/19/2011 0.00 Null Null none Null General Overview NIH-funded post-doctoral position available to study the pathogenic mechanisms of NUT midline carcinoma. NUT midline carcinoma (NMC) is an uncommon, but uniformly lethal disease defined by the presence of the chromatin-associated BRD-NUT fusion oncogene, either BRD4-NUT or BRD3-NUT. We have found that BRD-NUT blocks differentiation and maintains the growth of carcinoma cells in vitro and in vivo. The post-doctoral fellow will a) map and characterize the functional domains of BRD-NUT which are responsible for its ability to block differentiation, b) identify the proteins which bind BRD-NUT which collaborate the block differentiation, c) identify, by ChIP-seq, the genomic DNA with which BRD-NUT associates, and d) help develop a knock-in mouse model of NMC. The post-doctoral fellow will be expected to work and think independently, and may take a lead role in many of the aspects of the above projects Major Duties 1. Performs technical procedures such as ChIP, immunoprecipitation, western blotting, immunofluorescence, cell culture.
2. Performs recombinant DNA procedures such as plasmid subcloning and preparation, isolation of DNA nucleic acid hybridization, and polymerase chain reaction.
4. Prepares and maintains tissue and bacterial cultures.
5. Operates instruments and equipment such the fluorescent microscope, qPCR machine, PCR machine.
6. Operates ancillary equipment such as photographic equipment and computer equipment.
7. Conducts literature reviews to assist in determining most suitable methods to be used in research.
8. Prepares and presents written or oral progress reports concerning studies, including assembly, organization and interpretation of data.
9. Performs statistical analysis of data.
10. Prepares laboratory reagents, chemicals, instruments and equipment.
11. Orders chemicals, reagents and other laboratory supplies.
12. Performs routine maintenance and minor repairs of laboratory apparatus and instruments.
13. Maintains a clean, orderly work area within the laboratory.
14. Will assist in supervising the work of other assigned laboratory personnel.
15. Will teach various laboratory techniques to laboratory personnel, students and others.
16. Maintains established department policies, procedures and objectives, including the areas of quality assurance, safety, environmental and infection control.
17. Performs all other duties and responsibilities as directed. Skills/Abilities/Competencies Good written and oral communication skills.
Good organizational skills; detail oriented.
Good publication record highly desirable.
Ability to methodically record data with a very high level of accuracy.
Ability to work under general supervision.
Ability to perform a variety of routine tests.
Ability to prioritize work. Qualifications Recent MD or Postdoctoral degree in a biology/biochemistry/molecular biology required.
Strong experience in molecular and cell biology required.
Expertise in epigenetics desired.
3-4 years of laboratory experience required. Working Environment Normal laboratory environment.
May be exposed to radioactive and other hazardous materials, under controlled conditions. Minimal risk when proper protocols are observed and followed. Other Information Will assist in the supervision of other laboratory personnel including visiting graduate students and laboratory aides. ]]> 7/19/2011 0.00 Null Null none Null General Overview Postdoctoral Position in the Department of Medicine, Pulmonary and Critical Care Medicine Division.

We are currently seeking candidates for a postdoctoral position in the Pulmonary and Critical Care Medicine Division at Brigham and Womenand#x2019;s Hospital (DGHE; Harvard Medical School) in Boston, Massachusetts USA to work in a collaborative setting with a multidisciplinary team of physician scientists working in the field of lung fibrosis.

The research setting is a basic science laboratory run jointly by two investigators currently with 5 fellows. Research includes some translational aspects, spans commonly used molecular techniques and mouse work. Areas of interest include cell death, autophagy, fibroblast activation, stress response, DNA damage, senescence. Candidates will have training and experience in murine models of lung fibrosis and emphysema, protein and rna analysis, imaging, cloning, transfection and other common molecular biology techniques. Fellows will participate in several weekly research meetings and will have the opportunity to present at international meetings.

This position is for two years, with the possibility of extension.

Salary: US $42,900-$55,000 + benefits depending on experience. Start date is negotiable, but we seek to fill this position as soon as possible.

Applications: Applicants should send a CV and a letter describing their research interests with a brief summary of their Ph.D. work. A copy of any published or in press papers would be welcome. Also, please provide email addresses for two individuals who would be able to provide letters of reference.

Send applications to:
Dr. Danielle Morse
Pulmonary and Critical Care Medicine Division
Brigham and Womenand#x2019;s Hospital
75 Francis Street, Boston, MA 02115
EEO Statement: Brigham and Womenand#x2019;s Hospital is an EEO, AA and VEVRAA employer. ]]> 7/19/2011 0.00 Null Null none Null
Responsibilities: GENERAL OVERVIEW/ SUMMARY STATEMENT
A postdoctoral fellow position is immediately available to a highly motivated recent PhD (or MD/PhD) for studies related to endothelial cell biology and angiogenesis. A strong background in molecular biology is required.
EEO Statement: An EEO, AA, VEVRAA Employer ]]> 7/19/2011 0.00 Null Null none Null
Responsibilities: Brigham and Womenand#x2019;s Hospital, a teaching affiliate of Harvard Medical School, has the following position available at our Boston, MA medical center:

Job Description:

Radiologist: The Department of Radiology at Brigham and Womenand#x2019;s Hospital (BWH) is seeking a Radiologist to join a thriving and well-established Section of Emergency and Trauma Radiology at an academic, Level 1 trauma center with 700 beds and ~58K ED visits per year in an urban setting (Boston). The candidate must have Emergency Radiology fellowship training and/or two years of experience working as a full-time Radiologist in an Emergency Department setting. The radiologist will be responsible for interpretation of radiography, ultrasound, CT, and MR. Routine shifts include days, evenings and weekends, with the majority of the shifts outside of routine weekday hours. The radiologist will teach medical students, train fellows and residents, and lead the Advanced Post-Processing Initiative (3D imaging) for the Emergency Radiology section, including associated clinical research leading to publication in peer-reviewed scholarly journals. The Emergency Radiology section is located within the BWH Emergency Department (ED), a 52-bed facility equipped with co-located 128-MSCT, sonography, and CR/DR units. There are 13 dedicated emergency radiologists who cover all aspects of diagnostic imaging in the BWH ED, as well as providing regional emergency teleradiology services to several other hospitals/radiology practices. A rich array of advanced equipment and talented collaborators are available in a supportive institutional environment. In total, the section interprets approximately 120K exams/year. The radiology department is fully digital and equipment is state-of-the-art.
Requirements: Requirements:

M.D. or equivalent foreign degree AND one year of experience in Job Offered OR either: (1) completion of fellowship in Emergency Radiology or (2) one year of experience working as a full-time Radiologist in an Emergency Department setting.

Special Requirements:

and#x2022; Demonstrated Expertise (and#x201c;DEand#x201d;) developing 3-D images or programs.

and#x2022; DE in a clinical radiology subspecialty and#x2013; emergency, neuroradiology, thoracic, abdominal or MSK radiology.

and#x2022; DE performing clinical research and publishing scholarly findings in an academic publication or peer reviewed journal.

and#x2022; License to practice Medicine in Massachusetts.
Shift: Day Shift
EEO Statement: An EEO, AA, VEVRAA Employer ]]> 7/19/2011 0.00 Null Null none Null General Overview This research position requires a highly trained research scholar in cellular and molecular immunology who can perform various immunological experiments ranging from in vitro cell culture assays to in vivo animal experiments. In detail, handling of knock-outs, reporters and transgenic animals, isolation of various cells populations from spleen and lymph nodes will be required. Incumbent will also be involved in measuring various cytokines by ELISA and real time PCR in an autoimmune model of MS. Moreover, experience in molecular biology techniques such as plasmid isolation, cloning, DNA and RNA purification, retroviral expression of various molecules is also required. In addition to performing the experiments, candidate must also have experience in analyzing and interpreting experimental data and preparing research manuscripts. Major Duties 1.Independently design and perform experiments.
2.Responsible for data generation, interpretation and communication.
3.Establish and maintain collaborative relationships with both internal and external research groups.
4.Obtain research funding to support independent projects.
5.Supervise research technicians and students Skills/Abilities/Competencies and#x2022;Expertise in immune regulation and autoimmune diseases.
and#x2022;Experience in EAE animal model
and#x2022;Cloning, and generation of transgenic mice Qualifications and#x2022;PhD in immunology with minimum of four years postdoctoral experience.
and#x2022;Substantial publication record
and#x2022;Proven ability to obtain research grants
EEO Statement: Brigham and Womenand#x2019;s Hospital (BWH) is internationally known as a leader in cutting-edge research and technology and its commitment to patient-centered care. BWH has a rich legacy of excellence and has been consistently recognized as one of Americaand#x2019;s best hospitals by US News and World Report. ]]> 7/19/2011 0.00 Null Null none Null General Overview Cutting edge projects focusing on the innate immune mechanisms leading to adaptive immunity. These projects include novel pathways that regulate macrophages, and T cells, macrophage biology linked to autoimmune disease, determining the unique and shared role of the principle macrophage developmental molecules in immune mediated inflammation, and the power of the programmed death pathway in regulating tissue injury. Furthermore, studies focus on tissue regenerative pathways mediated by resident cells and macrophages, and inflammation that fails to resolve and leads to disease. Unique transgenic strains and knockout mice with reporter genes have been constructed on autoimmune susceptible strains for these projects. These projects dissect the basic mechanisms of autoimmune disease (kidney, skin, heart) and have human translational components.

Experience:
Immunology, and/or Molecular biology and Cell Biology
Knowledge of histopathology desirable
Mouse systems
Computer literacy is necessary

Desired:
Responsible, hard-working individual who is able to multi-task and to work independently

MD, or PhD required, position for two years or longer within the Department of Medicine, Brigham and Womenand#x2019;s Hospital.

Please send three references.

Interested candidates contact: Dr. Vicki Rubin Kelley, Harvard Institutes of Medicine, 4 Blackfan Circle, Boston, MA 02115; FAX 617-525-5830; e-mail: vkelley@rics.bwh.harvard.edu

Brigham and Womenand#x2019;s Hospital is an EEO, AA and VEVRAA employer. ]]> 7/19/2011 0.00 Null Null none Null General Overview Postdoctoral position is available in a Cerebrovascular Research Laboratory to study the genetics and mechanisms of cerebral vasospasm, which occurs in the presence of subarachnoid hemorrhage. Major Duties 1. Designs experiments and interprets results.
2. Performs technical procedures such as immunohistochemistry, PCR, Wester blots, or other assays; prepares materials for microscopic examination.
3. Maintains mouse colonies and performs experiments in vivo, including microsurgery.
4. Harvests and prepares tissues from in vivo experiments for analysis.
5. Obtains, prepares and processes blood and tissue specimens from human subjects.
6. Prepares and maintains tissue and cell cultures.
7. Operates instruments and equipment such as cryotomes, centrifuges, incubators and fluorescent microscopes.
8. Operates ancillary equipment such as photographic equipment and computer equipment.
9. Manages and maintains database containing experimental results and reagent information and storage locations
10. Conducts literature reviews to assist in determining most suitable methods to be used in research.
11. Prepares and presents written or oral progress reports concerning studies, including assembly, organization and interpretation of data.
12. Performs statistical analysis of data.
13. Prepares laboratory reagents, chemicals, instruments and equipment.
14. Orders chemicals, reagents and other laboratory supplies.
15. Performs routine maintenance and minor repairs of laboratory apparatus and instruments.
16. Maintains a clean, orderly work area within the laboratory.
17. Undertakes standard decontamination procedures prior to disposal of certain laboratory materials.
18. Functions as the laboratory safety officer, responsible for compliance with all regulatory requirements, and the safe use of hazardous materials in the laboratory, including radioactive, biological and chemical agents.
19. May write computer programs.
20. May assist in supervising the work of other assigned laboratory personnel.
21. May demonstrate and explain various laboratory techniques to laboratory personnel, students and others.
22. Maintains established department policies, procedures and objectives, including the areas of quality assurance, safety, environmental and infection control.
23. Performs all other duties and responsibilities as directed.
EEO Statement: Brigham and Womenand#x2019;s Hospital is an EEO, AA and VEVRAA employer. Other Information Contact Information
Rose Du, MD, PhD
Department of Neurosurgery
Brigham and Womenand#x2019;s Hospital
Harvard Medical School
75 Francis Street
Boston, MA 02115
rdu@partners.org ]]> 7/19/2011 0.00 Null Null none Null General Overview We are looking to recruit a highly motivated postdoctoral research fellow to join a Advanced Endoscopy and bariatric research group. Dr. Christopher C. Thompsonand#x2019;s Laboratory is part of the Division of Gastroenterology, Hepatology and Endoscopy at Brigham and Womenand#x2019;s Hospital/Harvard Medical School. The focus of the research will be on the development of new endoscopic approaches for the treatment of GI and pancreatobiliary disorders and obesity. Projects might include device trials in ex vivo and rodent models, analysis of obesity related databases, translation of techniques into large animals and humans. In addition, the project will involve the integration of results with clinical studies aiming to address weight regain in the post-bypass patient or primary obesity therapies. This is a unique opportunity for working in a fast-paced, and highly collaborative, developmental and translational research group working at the interface of clinical investigation, biology, and therapeutic development. Major Duties 1. Working closely with basic science and clinical collaborators to design and execute experiments with human clinical specimens and model organisms.
2. Independently performs experiments which are moderate to complex.
3. Maintain rodent colonies.
4. Coordinates schedules of tests and procedures.
5. Record data, summarizes, and analyzes results using basic statistics.
6. Prepares laboratory reagents, chemicals, instruments, and equipment.
7. Maintains supplies inventory in accordance with laboratory procedures.
8. Discusses progress of work regularly with supervisor.
9. Calculate, transcribes and analyzes data using advanced statistical techniques.
10. In collaboration with PI or Research Lab Manager, establishes new and modifies existing research techniques.
11. In collaboration with the PI and Research Lab Manger, writes grants for submission to institutional, society and/or federal funding opportunities.
12. All other duties as assigned. Skills/Abilities/Competencies and#x2022; Must have experience with rodent models.
and#x2022; Ability to work independently.
and#x2022; Must have basic surgical skills and understanding of rodent anatomy.
and#x2022; High degree of computer literacy.
and#x2022; Sound analytical and organizational skills.
and#x2022; Requires good oral and written communication skills.
and#x2022; Must be able to logically and effectively structure tasks and set priorities.
and#x2022; Ability to identify potential problems and trouble-shoot solutions.
and#x2022; Demonstrated ability to analyze data statistically and to logically present it. Qualifications - Ph.D., MD/Ph.D., or MD in Surgery, Gastroenterology, Internal Medicine, Endocrinology and/or Biology required. Engineering degrees will be considered.

- Experience with statistical and programming skills preferred.

- Demonstrated success in technical proficiency, scientific creativity, collaboration with others and independent thought.

- Must have at least 1 year of research with rodent models.

- Proven record of significant contributions to research projects as individual contributor.

- Excellent communication skills
EEO Statement: Brigham and Womenand#x2019;s Hospital is an EEO, AA and VEVRAA employer. ]]> 7/19/2011 0.00 Null Null none Null General Overview The Personalized Cancer Medicine Partnership (PCMP) is a collaborative venture between two Harvard Medical School affiliated institutions- the Brigham and Women's Hospital and the Dana-Farber Cancer Institute. The mission of the PCMP is to advance translational and personalized cancer medicine by implementing tumor genomic profiling on all cancer patients treated at these institutions. PCMP will employ state-of-the art technology to generate a detailed profile of key andquot;druggableandquot; or otherwise andquot;actionableandquot; cancer genomic alterations in a CLIA-approved and andquot;real-timeandquot; process to facilitate rapid clinical application. These cancer genomic profiles with be used to guide patient treatment and/or stratification for clinical trials of novel anticancer agents.

This exceptional opportunity offers the chance to work at the forefront of discovery and translational cancer technologies and applications. We seek a Data Analyst to actively participate in data generation, analysis and reporting of genomic results (including sequencing and/or mass-spec genotyping). More specifically, he/she will have the following responsibilities, including but not limited to:

and#x2022;Incorporate existing algorithms for mutation detection in clinical samples and determine relevant performance characteristics
and#x2022;Generate semi-automated reports to aid with analysis and interpretation of genomic data
and#x2022;Coordinate mutation detection strategies with the bioinformatics and laboratory teams
and#x2022;Assist with genome analysis software implementation, including mutation detection and copy number analyses Qualifications and#x2022;MSc (PhD-preferred) with 2+ years experience working in laboratories with a concentration in genomics research or bioinformatic analyses of genomic data
and#x2022;Highly organized and self-directed individual, who works well in a complex and dynamic environment.
and#x2022;Ability to work closely and effectively with a diverse group of individuals from trainees to senior academic leaders in both clinical and scientific arenas.
and#x2022;Excellent computer, analytical and communication skills.

A minimum two-year commitment is required.
EEO Statement: Brigham and Womenand#x2019;s Hospital is an EEO, AA and VEVRAA employer. ]]> 7/19/2011 0.00 Null Null none Null
Responsibilities: GENERAL SUMMARY/ OVERVIEW STATEMENT
Radiation oncology clinical physicists are professionals primarily engaged in the evaluation, planning, delivery and optimization of radiation treatments. A primary responsibility is the accurate determination and specification of the radiation dosage for each treatment. The treatment planning functions include consultation with the clinician to design treatment plans, the preparation of the technical details for the deliveries, the correct implementation of the treatment plan, and the quality assurance and progress review of the treatment. Physicists with expertise in computer science applications will develop digital solutions to provide cost effective processes to integrate the above activities. At a more basic but critical level, clinical physicists develop and implement radiation dosimetry protocols and data bases for all radiation sources in the department (from machines, and sealed brachytherapy sources) to meet national and State standards. They report to the section chief or the Chief of Medical Physics.

PRINCIPAL DUTIES/ RESPONSIBILITIES
A. Patient Care:
1. Work along side with radiation oncologists to provide all the needed support for safe radiation treatments, including simulations, image processing, treatment plan designs and treatment deliveries to ensure correct radiation dosages and patient safety including decision to suspend treatments when necessary.
2. Participate and supervise all brachytherapy applications including dosimetric verification, treatment planning, documentation, and all radiation safety issues, including decision to stop treatments.
3. Implement special irradiation procedures, such as intensity modulated therapy, image guided radiation therapy, total body irradiation, stereotactic radiosurgery.
4. Participate in departmental chart reviews, experimental trials, national clinical protocols, and provide documentation to support these efforts.
5. Coordinate with other departments and integrate medical imaging information to assure patient care is seamless.

B. Clinical physics duties:
1. Develop and implement protocols for radiation dose specifications to meet national and state regulations.
2. Develop and maintain a State mandated Quality Management Program (QMP) covering external beam procedures and material license applications (brachytherapy and radiopharmaceuticals for therapy)
3. Develop and implement quality assurance programs and dosimetric verification procedures for patients undergoing treatments.
4. Design treatment facilities to meet the national and State radiation protection guidelines.
5. Assume key role in purchase acquisition, installation, and commissioning of all new machines and treatment planning systems.
6. Design computer programs to improve comprehensive analyses, processing and integration of imaging, planning and delivery information for maximum operational efficiency and accuracy. This is essential for image-guided and robotic techniques.
7. Work with engineers in the diagnosis, repair, maintenance, including assessment for release of treatment machines for clinical use.

C. Leadership and management responsibilities:
1. Assist in supervision, coaching, training of dosimetrists, junior physicists, and physics assistants, and other radiation therapy personnel.
2. Assist section chief in management of team effort.
3. Assist the hospital administration by assuming a key role in managing the technical aspects of clinical programs: implementation, quality assurance, documentation.
4. Apply quality improvement measures to enhance efficiency and safety of clinical programs.
5. Work closely with administration to provide accurate documentation for billing and charge capture to insure compliance.
6. Work with Administration on strategic and fiscal planning for on campus and outreach programs.

D. Teaching and Research and Development:
1. When appropriate, participate in the teaching of therapist students, post-doctoral fellows and clinical residents in radiation oncology.
2. When appropriate, participate in research and development projects under supervision and direction of faculty member.
Requirements: QUALIFICATIONS
A. Education:
At least a Masters Degree in Medical Physics

B. Experience:
At least 3 years of clinical experience in radiation oncology physics following the completion of the terminal Medical Physics degree. Evidence of the ability to act in a leadership/management role in his/her area of expertise. Computer programming experience is preferred.
Shift: Day Shift
EEO Statement: An EEO, AA, VEVRAA Employer ]]> 7/19/2011 0.00 Null Null none Null General Overview Under the supervision of the Principal Investigator, independently carries out and designs highly sophisticated and independent experiments. Will work in laboratory space dedicated to principal investigator with additional potential to establish successful project-specific collaborations in a variety-of directions. Major Duties 1. Researches, develops, designs, executes and interprets research experiments.
2. Contributes to scientific literature, reports, journals and presentations.
3. Investigates, creates and develops new methods and technologies for research advancement. Skills/Abilities/Competencies and#x2022; Strong research design and analytical skills.
and#x2022; Strong database statistical skills.
and#x2022; In-depth knowledge of field of research.
and#x2022; Excellent time management/organizational skills.
and#x2022; Strong written and verbal presentation skills. Qualifications The successful candidate will have recently completed graduate studies in an MD, PhD, or MD/PhD program with a strong research and publication record in the biological sciences.
EEO Statement: Brigham and Womenand#x2019;s Hospital is an EEO, AA and VEVRAA employer. ]]> 7/19/2011 0.00 Null Null none Null General Overview This research position requires a Senior Post-Doc or Instructor level candidate with a background in transplant immunology and publications in the field. The applicant should have experience in relevant in-vivo and in-vitro methods such as RT-PCR, FACS, cell-separation and -culture, immunohistochemistry, and immunoassays. In additional to performing experiments, the incumbent must also have experience in analyzing and interpreting experimental data and preparing research manuscripts and grants. Under the direction of the PI, the applicant will independently perform sophisticated experiments and will participate in the design of experimental protocols. Microsurgical experience is not a prerequisite but preferable.
Responsibilities: and#x2022;Responsible for data generation, interpretation and communication.
and#x2022;Micro Surgical experience preferred.
and#x2022;Establish and maintain collaborative relationships with both internal and external research groups.
and#x2022;Independently designs and executes experiments.
and#x2022;Obtain research funding to support independent projects. Skills/Abilities/Competencies and#x2022;Must be able to make independent, effective decisions.
and#x2022;Must possess a scientific imagination commensurate with the independent execution of research projects.
and#x2022;Demonstrated analytical skills and ability to logically sequence experiments to maximize research.
and#x2022;Must have aptitude for technical problem solving.
and#x2022;Should have experience in performing the following methods: isolation of immune cells from spleen, blood, kidney, and heart. Flow cytometry, mixed lymphocyte culture, ELISA, ELISPOT, immunohistochemistry, real time RT-PCR, Luminex. Qualifications and#x2022;PhD with minimum of two years postdoctoral experience.
and#x2022;Substantial publication record.
and#x2022;Micro Surgical experience preferred.
and#x2022;Proven ability to obtain research grants. Working Environment and#x2022;Normal laboratory environment.
and#x2022;May work with and/or be exposed to radioactive and other hazardous materials, under controlled conditions.
EEO Statement: Brigham and Womenand#x2019;s Hospital is an EEO, AA and VEVRAA employer. ]]> 7/19/2011 0.00 Null Null none Null General Overview Under the supervision of the Principal Investigator, independently carries out and designs highly sophisticated and independent experiments. Will work in laboratory space dedicated to principal investigator with additional potential to establish successful project-specific collaborations in a variety-of directions.
Responsibilities: 1.Researches, develops, designs, executes and interprets research experiments.
2.Contributes to scientific literature, reports, journals and presentations.
3.Investigates, creates and develops new methods and technologies for research advancement. Qualifications The successful candidate will have recently completed graduate studies in an MD, PhD, or MD/PhD program with a strong research and publication record in the biological sciences. Qualifications
EEO Statement: Brigham and Womenand#x2019;s Hospital is an EEO, AA and VEVRAA employer. ]]> 7/19/2011 0.00 Null Null none Null General Overview NIH-funded post-doctoral position available to study the pathogenic mechanisms of NUT midline carcinoma. NUT midline carcinoma (NMC) is an uncommon, but uniformly lethal disease defined by the presence of the chromatin-associated BRD-NUT fusion oncogene, either BRD4-NUT or BRD3-NUT. We have found that BRD-NUT blocks differentiation and maintains the growth of carcinoma cells in vitro and in vivo. The post-doctoral fellow will a) map and characterize the functional domains of BRD-NUT which are responsible for its ability to block differentiation, b) identify the proteins which bind BRD-NUT which collaborate the block differentiation, c) identify, by ChIP-seq, the genomic DNA with which BRD-NUT associates, and d) help develop a knock-in mouse model of NMC. The post-doctoral fellow will be expected to work and think independently, and may take a lead role in many of the aspects of the above projects Major Duties 1. Performs technical procedures such as ChIP, immunoprecipitation, western blotting, immunofluorescence, cell culture.
2. Performs recombinant DNA procedures such as plasmid subcloning and preparation, isolation of DNA nucleic acid hybridization, and polymerase chain reaction.
4. Prepares and maintains tissue and bacterial cultures.
5. Operates instruments and equipment such the fluorescent microscope, qPCR machine, PCR machine.
6. Operates ancillary equipment such as photographic equipment and computer equipment.
7. Conducts literature reviews to assist in determining most suitable methods to be used in research.
8. Prepares and presents written or oral progress reports concerning studies, including assembly, organization and interpretation of data.
9. Performs statistical analysis of data.
10. Prepares laboratory reagents, chemicals, instruments and equipment.
11. Orders chemicals, reagents and other laboratory supplies.
12. Performs routine maintenance and minor repairs of laboratory apparatus and instruments.
13. Maintains a clean, orderly work area within the laboratory.
14. Will assist in supervising the work of other assigned laboratory personnel.
15. Will teach various laboratory techniques to laboratory personnel, students and others.
16. Maintains established department policies, procedures and objectives, including the areas of quality assurance, safety, environmental and infection control.
17. Performs all other duties and responsibilities as directed. Skills/Abilities/Competencies Good written and oral communication skills.
Good organizational skills; detail oriented.
Good publication record highly desirable.
Ability to methodically record data with a very high level of accuracy.
Ability to work under general supervision.
Ability to perform a variety of routine tests.
Ability to prioritize work. Qualifications Recent MD or Postdoctoral degree in a biology/biochemistry/molecular biology required.
Strong experience in molecular and cell biology required.
Expertise in epigenetics desired.
3-4 years of laboratory experience required. Working Environment Normal laboratory environment.
May be exposed to radioactive and other hazardous materials, under controlled conditions. Minimal risk when proper protocols are observed and followed. Other Information Will assist in the supervision of other laboratory personnel including visiting graduate students and laboratory aides. ]]> 7/19/2011 0.00 Null Null none Null General Overview Postdoctoral Position in the Department of Medicine, Pulmonary and Critical Care Medicine Division.

We are currently seeking candidates for a postdoctoral position in the Pulmonary and Critical Care Medicine Division at Brigham and Womenand#x2019;s Hospital (DGHE; Harvard Medical School) in Boston, Massachusetts USA to work in a collaborative setting with a multidisciplinary team of physician scientists working in the field of lung fibrosis.

The research setting is a basic science laboratory run jointly by two investigators currently with 5 fellows. Research includes some translational aspects, spans commonly used molecular techniques and mouse work. Areas of interest include cell death, autophagy, fibroblast activation, stress response, DNA damage, senescence. Candidates will have training and experience in murine models of lung fibrosis and emphysema, protein and rna analysis, imaging, cloning, transfection and other common molecular biology techniques. Fellows will participate in several weekly research meetings and will have the opportunity to present at international meetings.

This position is for two years, with the possibility of extension.

Salary: US $42,900-$55,000 + benefits depending on experience. Start date is negotiable, but we seek to fill this position as soon as possible.

Applications: Applicants should send a CV and a letter describing their research interests with a brief summary of their Ph.D. work. A copy of any published or in press papers would be welcome. Also, please provide email addresses for two individuals who would be able to provide letters of reference.

Send applications to:
Dr. Danielle Morse
Pulmonary and Critical Care Medicine Division
Brigham and Womenand#x2019;s Hospital
75 Francis Street, Boston, MA 02115
EEO Statement: Brigham and Womenand#x2019;s Hospital is an EEO, AA and VEVRAA employer. ]]> 7/19/2011 0.00 Null Null none Null
Responsibilities: GENERAL OVERVIEW/ SUMMARY STATEMENT
A postdoctoral fellow position is immediately available to a highly motivated recent PhD (or MD/PhD) for studies related to endothelial cell biology and angiogenesis. A strong background in molecular biology is required.
EEO Statement: An EEO, AA, VEVRAA Employer ]]> 7/19/2011 0.00 Null Null none Null
Responsibilities: Brigham and Womenand#x2019;s Hospital, a teaching affiliate of Harvard Medical School, has the following position available at our Boston, MA medical center:

Job Description:

Radiologist: The Department of Radiology at Brigham and Womenand#x2019;s Hospital (BWH) is seeking a Radiologist to join a thriving and well-established Section of Emergency and Trauma Radiology at an academic, Level 1 trauma center with 700 beds and ~58K ED visits per year in an urban setting (Boston). The candidate must have Emergency Radiology fellowship training and/or two years of experience working as a full-time Radiologist in an Emergency Department setting. The radiologist will be responsible for interpretation of radiography, ultrasound, CT, and MR. Routine shifts include days, evenings and weekends, with the majority of the shifts outside of routine weekday hours. The radiologist will teach medical students, train fellows and residents, and lead the Advanced Post-Processing Initiative (3D imaging) for the Emergency Radiology section, including associated clinical research leading to publication in peer-reviewed scholarly journals. The Emergency Radiology section is located within the BWH Emergency Department (ED), a 52-bed facility equipped with co-located 128-MSCT, sonography, and CR/DR units. There are 13 dedicated emergency radiologists who cover all aspects of diagnostic imaging in the BWH ED, as well as providing regional emergency teleradiology services to several other hospitals/radiology practices. A rich array of advanced equipment and talented collaborators are available in a supportive institutional environment. In total, the section interprets approximately 120K exams/year. The radiology department is fully digital and equipment is state-of-the-art.
Requirements: Requirements:

M.D. or equivalent foreign degree AND one year of experience in Job Offered OR either: (1) completion of fellowship in Emergency Radiology or (2) one year of experience working as a full-time Radiologist in an Emergency Department setting.

Special Requirements:

and#x2022; Demonstrated Expertise (and#x201c;DEand#x201d;) developing 3-D images or programs.

and#x2022; DE in a clinical radiology subspecialty and#x2013; emergency, neuroradiology, thoracic, abdominal or MSK radiology.

and#x2022; DE performing clinical research and publishing scholarly findings in an academic publication or peer reviewed journal.

and#x2022; License to practice Medicine in Massachusetts.
Shift: Day Shift
EEO Statement: An EEO, AA, VEVRAA Employer ]]> 7/19/2011 0.00