MedWorm: Cancer & Oncology

Aspirin, LMWH prevent VTE in patients treated for multiple myeloma

MedWire News - Oncology — Fri, 10 Feb 2012 17:07:12 +0100

Thromboprophylaxis with either aspirin or low molecular weight heparin is associated with a low incidence of venous thromboembolism among patients with newly diagnosed multiple myeloma receiving lenalidomide-based treatment, Italian researchers report. (Source: MedWire News - Oncology)

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AL Amyloidosis: Who, What, When, Why, and Where

Cancer Network — Fri, 10 Feb 2012 17:00:01 +0100

In the current issue of ONCOLOGY, Gertz and Dispenzieri provide a scholarly review of the early recognition, diagnosis, and treatment of immunoglobulin light-chain (AL) amyloidosis. (Source: Cancer Network)

The role of ATM and 53BP1 as predictive markers in cervical cancer

International Journal of Cancer — Fri, 10 Feb 2012 15:59:17 +0100

In conclusion, both our in vitro and patient‐related findings indicate a protective role for ATM in response to (chemo)radiation in cervical cancer and point at ATM inhibition as a possible means to improve efficacy of (chemo)radiation. © 2012 Wiley‐Liss, Inc. (Source: International Journal of Cancer)

Exercise Dependence of N-Terminal Pro-Brain Natriuretic Peptide in Patients with Precapillary Pulmonary Hypertension

Karger Publishers — Fri, 10 Feb 2012 14:54:46 +0100

Respiration (DOI:10.1159/000334950) (Source: Karger Publishers)

Predictors of Adverse Outcome in Patients Hospitalised for Exacerbation of Chronic Obstructive Pulmonary Disease

Karger Publishers — Fri, 10 Feb 2012 14:54:46 +0100

Respiration (DOI:10.1159/000335467) (Source: Karger Publishers)

Nomograms for Prognostication of Outcome in Patients with Esophageal and Gastroesophageal Carcinoma Undergoing Definitive Chemoradiotherapy

Karger Publishers — Fri, 10 Feb 2012 14:54:45 +0100

Oncology 2012;82:108-113 (DOI:10.1159/000335951) (Source: Karger Publishers)

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Breast Cancers Detected by Breast MRI Screening and Ultrasound in Asymptomatic Asian Women: 8 Years of Experience in Taiwan

Karger Publishers — Fri, 10 Feb 2012 14:54:45 +0100

Oncology 2012;82:98-107 (DOI:10.1159/000335958) (Source: Karger Publishers)

Vitamin D in Relation to Myocardial Structure and Function after Eight Years of Follow-Up: The Hoorn Study

Karger Publishers — Fri, 10 Feb 2012 14:54:45 +0100

Ann Nutr Metab 2012;60:69-77 (DOI:10.1159/000336173) (Source: Karger Publishers)

A Prevalent Y;15 Translocation in the Ethiopian Beta Israel Community in Israel

Karger Publishers — Fri, 10 Feb 2012 14:54:45 +0100

Cytogenet Genome Res (DOI:10.1159/000336201) (Source: Karger Publishers)

Molecular Insights into X;BTA5 Chromosome Rearrangements in the Tribe Antilopini (Bovidae)

Karger Publishers — Fri, 10 Feb 2012 14:54:45 +0100

Cytogenet Genome Res (DOI:10.1159/000336248) (Source: Karger Publishers)

Nutrition and Acne: Therapeutic Potential of Ketogenic Diets

Karger Publishers — Fri, 10 Feb 2012 14:54:45 +0100

Skin Pharmacol Physiol 2012;25:111-117 (DOI:10.1159/000336404) (Source: Karger Publishers)

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Expression Levels of Transcribed Ultraconserved Regions uc.73 and uc.388 Are Altered in Colorectal Cancer

Karger Publishers — Fri, 10 Feb 2012 14:54:45 +0100

Oncology 2012;82:114-118 (DOI:10.1159/000336479) (Source: Karger Publishers)

Cerebrospinal Fluid Biomarkers and Proximity to Diagnosis in Preclinical Familial Alzheimer's Disease

Karger Publishers — Fri, 10 Feb 2012 14:54:45 +0100

Dement Geriatr Cogn Disord 2012;33:1-5 (DOI:10.1159/000335729) (Source: Karger Publishers)

Neoadjuvant Use of Sunitinib in Locally Advanced GIST with Intolerance to Imatinib

Chemotherapy — Fri, 10 Feb 2012 14:54:44 +0100

Chemotherapy 2012;58:30-33 (DOI:10.1159/000333386) (Source: Chemotherapy)

Synergistic Effects of Combination Treatment with Bortezomib and Doxorubicin in Human Neuroblastoma Cell Lines

Chemotherapy — Fri, 10 Feb 2012 14:54:44 +0100

Chemotherapy 2012;58:44-51 (DOI:10.1159/000335603) (Source: Chemotherapy)

Excision of Nonpalpable Breast Cancer with Indocyanine Green Fluorescence-Guided Occult Lesion Localization (IFOLL)

Breast Care : Last 20 articles — Fri, 10 Feb 2012 14:54:43 +0100

Breast Care 2012;7:3 (DOI:10.1159/000336497) (Source: Breast Care : Last 20 articles)

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Use of Adjuvant Endocrine Therapy in Postmenopausal Hormone Receptor-Positive Breast Cancer at German Breast Cancer Centers and University Hospitals - Results of an Enquiry (Adjuvant Endocrine Therapy Enquiry)

Breast Care : Last 20 articles — Fri, 10 Feb 2012 14:54:43 +0100

Breast Care 2012;7:5 (DOI:10.1159/000336531) (Source: Breast Care : Last 20 articles)

Analysis of Clinical Features and Outcome of 356 Triple-Negative Breast Cancer Patients in China

Breast Care : Last 20 articles — Fri, 10 Feb 2012 14:54:43 +0100

Breast Care 2012;7:2 (DOI:10.1159/000336539) (Source: Breast Care : Last 20 articles)

The 70-Gene Signature as Prognostic Factor for Elderly Women with Hormone Receptor-Positive, HER2-Negative Breast Cancer

Breast Care : Last 20 articles — Fri, 10 Feb 2012 14:54:43 +0100

Breast Care 2012;7:4 (DOI:10.1159/000336552) (Source: Breast Care : Last 20 articles)

Health roundup: Alzheimers, defensive doctors

USATODAY.com Health — Fri, 10 Feb 2012 14:36:47 +0100

A cancer drug reverses Alzheimer's in mice, orthopedic surgeons order unneeded tests and communities accept "toilet-to-tap" water plans. (Source: USATODAY.com Health)

Chemo not always harmful in pregnancy

CTV Health — Fri, 10 Feb 2012 13:39:08 +0100

Researchers have encouraging news for women who find themselves in a very frightening situation: having cancer while pregnant. Studies suggest that these women can be treated almost the same as other cancer patients are, with minimal risk to the fetus. (Source: CTV Health)

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Cancer screening rates lower for Asians and Hispanics than other groups

American Medical News - HEALTH — Fri, 10 Feb 2012 13:21:09 +0100

Forty-seven percent received colorectal cancer screening in 2010 compared with 60% of whites, data show. Disparities also exist in testing for breast and cervical cancers. (Source: American Medical News - HEALTH)

The effect of hepatitis C treatment and human immunodeficiency virus (HIV) co‐infection on the disease burden of hepatitis C among injecting drug users in Amsterdam

Addiction — Fri, 10 Feb 2012 12:34:05 +0100

Conclusions The hepatitis C virus burden among injecting drug users in Amsterdam has been reduced by a high competing mortality rate, particularly caused by HIV infection, and to a smaller extent by hepatitis C virus treatment. Improved hepatitis C virus treatment is expected to contribute to reduce the future hepatitis C virus disease burden. (Source: Addiction)

Cancer drug reverses Alzheimer's in mice

New Scientist - Health — Fri, 10 Feb 2012 12:16:00 +0100

A drug approved for use in humans reverses Alzheimer's disease in mice, but may not have such dramatic effects in people with the condition (Source: New Scientist - Health)

Cel-Sci looking for more sources of funding

bizjournals.com Health Care:Physician Practices headlines — Fri, 10 Feb 2012 11:07:30 +0100

Vienna-based Cel-Sci Corp., with final-stage clinical trials for its lead cancer drug under way, says it intends to find partners or other sources of funding to continue operations this year. Cel-Sci posted a net loss of $4.2 million, or 2 cents per share, in its fiscal first quarter, compared with a net loss of $6.3 million, or 3 cents per share, a year earlier as expenses for its Phase III clinical trials for Multikine slowed. Research and development costs fell to $2.5 million last quarter, compared with $3... (Source: bizjournals.com Health Care:Physician Practices headlines)

Jefferson Hospitals leader retiring

bizjournals.com Health Care:Physician Practices headlines — Fri, 10 Feb 2012 11:02:03 +0100

Tom Lewis is retiring as president and CEO of Thomas Jefferson University Hospitals this summer after 36 years with the Center City medical center, the Philadelphia Business Journal reports. “Tom’s leadership and dedication has helped establish TJUH as a nationally recognized institution in fields such as orthopedics, digestive diseases, heart and vascular care, oncology, and neuroscience” said David F. Simon, executive vice president of Jefferson Health System (Source: bizjournals.com Health Care:Physician Practices headlines)

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Roche Molecular Gains FDA Clearance for Its Companion Diagnostic Test for New Skin Cancer Drug

Dark Daily — Fri, 10 Feb 2012 11:00:53 +0100

Clinical laboratory managers and pathologists can expect more companion diagnostics in responses to advances in molecular knowledge about various diseases Recently, the Food and Drug Administration (FDA) cleared two products for market, one of which may be of particular interest to anatomic pathologists. The first product is a therapeutic drug for the treatment of late-stage [...] (Source: Dark Daily)

Cancer Drug Reverses Symptoms Of Alzheimer's In Mice

Health News from Medical News Today — Fri, 10 Feb 2012 11:00:00 +0100

A drug approved for the treatment of cancer appears to quickly reverse the symptoms of Alzheimer's in mice, according to a new study from the US published in the journal Science on Thursday. The Food and Drug Administration (FDA) approved bexarotene as a treatment for cutaneous T cell lymphoma, a type of skin cancer, in 2000. Now a team of neuroscientists has shown that when they gave the drug to mice with Alzheimer's disease, it quickly reversed the pathological, cognitive and memory deficits that accompanies it. About 5... (Source: Health News from Medical News Today)

Fasting May Boost Chemo By Weakening Cancer Cells

Health News from Medical News Today — Fri, 10 Feb 2012 09:00:00 +0100

Fasting was as effective as chemotherapy in delaying growth of specific tumors in mice and boosted the effectiveness of chemotherapy on melanoma, glioma, and breast cancer cells. And fasting plus chemotherapy, but neither treatment on its own, resulted in long-term cancer-free survival in mice with neuroblastoma, according to a study published online on Wednesday in Science Translational Medicine... (Source: Health News from Medical News Today)

Guideline For Brain Metastases Developed By ASTRO

Health News from Medical News Today — Fri, 10 Feb 2012 09:00:00 +0100

The American Society for Radiation Oncology (ASTRO) has developed a guideline on the radiotherapeutic and surgical management for newly diagnosed brain metastases. It has been published in Practical Radiation Oncology (PRO), ASTRO's official clinical practice journal. "This guideline was developed by an international multidisciplinary task force charged with systematically reviewing and synthesizing level one and other high-quality data into a distilled work product," Eric L. Chang, MD, a radiation oncologist at the University of Southern California Keck School of Medicine, said... (Source: Health News from Medical News Today)

How DNA Finds Its Match

Health News from Medical News Today — Fri, 10 Feb 2012 09:00:00 +0100

It's been more than 50 years since James Watson and Francis Crick showed that DNA is a double helix of two strands that complement each other. But how does a short piece of DNA find its match, out of the millions of 'letters' in even a small genome? New work by researchers at the University of California, Davis, handling and observing single molecules of DNA, shows how it's done. The results are published online by the journal Nature. Defects in DNA repair and copying are strongly linked to cancer, birth defects and other problems... (Source: Health News from Medical News Today)

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Sugar molecules enabled efficient detection of precancerous cells in esophagus

HemOncToday.com — Fri, 10 Feb 2012 08:34:00 +0100

Bird-Lieberman EL. Nat Med. 2012;doi:10.1038/nm.2616. (Source: HemOncToday.com)

AML relapse may result from clonal mutation, chemotherapy

HemOncToday.com — Fri, 10 Feb 2012 08:15:00 +0100

Ding L. Nature. 2012;481:506-510. (Source: HemOncToday.com)

Identifying Cancer Cells For Immune System Attack With DNA Sequencing

Health News from Medical News Today — Fri, 10 Feb 2012 08:00:00 +0100

DNA sequences from tumor cells can be used to direct the immune system to attack cancer, according to scientists at Washington University School of Medicine in St. Louis. The research, in mice, appears online in Nature. The immune system relies on an intricate network of alarm bells, targets and safety brakes to determine when and what to attack. The new results suggest that scientists may now be able to combine DNA sequencing data with their knowledge of the triggers and targets that set off immune alarms to more precisely develop vaccines and other immunotherapies for cancer... (Source: Health News from Medical News Today)

Gay, Lesbian, Bisexual And Transgendered Adults Have Twice The Level Of Smoking And Half The Level Of Plans To Quit

Health News from Medical News Today — Fri, 10 Feb 2012 08:00:00 +0100

Gay, lesbian, bisexual and transgendered Coloradans who smoke are not thinking about quitting or getting ready to quit, and a quarter are uncomfortable approaching their doctors for help, report University of Colorado Cancer Center researchers in a recent article published in Nicotine & Tobacco Research. These and other findings from the study may help identify new approaches to encourage GLBT smokers to quit... (Source: Health News from Medical News Today)

How Early Breast Tumors Become Deadly

Health News from Medical News Today — Fri, 10 Feb 2012 08:00:00 +0100

Researchers have discovered a restricted pattern of molecules that differentiate early-stage breast tumors from invasive, life-threatening cancer. They also found a similar molecular signature that correlated with the aggressiveness of invasive tumors, and with the time to metastasis and overall survival. Researchers at the Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J... (Source: Health News from Medical News Today)

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Similarities Between Genetic Signatures In Developing Organs And Breast Cancer Could Predict And Personalize Cancer Therapies

Health News from Medical News Today — Fri, 10 Feb 2012 08:00:00 +0100

Reviving a theory first proposed in the late 1800s that the development of organs in the normal embryo and the development of cancers are related, scientists at the Salk Institute for Biological Studies have studied organ development in mice to unravel how breast cancers, and perhaps other cancers, develop in people. Their findings provide new ways to predict and personalize the diagnosis and treatment of cancer... (Source: Health News from Medical News Today)

Efficacy of anti‐insulin like growth factor i receptor (IGF‐IR) monoclonal antibody cixutumumab in mesothelioma is highly correlated with IGF‐IR sites/cell

International Journal of Cancer — Fri, 10 Feb 2012 05:00:00 +0100

AbstractInsulin growth factor‐I receptor (IGF‐IR) is expressed in mesothelioma and therefore an attractive target for therapy. The anti‐tumor activity of cixutumumab, a humanized monoclonal antibody to IGF‐IR, in mesothelioma and relationship to IGF‐IR expression was investigated using eight early passage tumor cells obtained from patients, nine established cell lines and an in vivo human mesothelioma tumor xenograft model. Although IGF‐IR expression at the mRNA and protein level was present in all mesothelioma cells, using a quantitative ELISA immunoassay there was considerable variability of IGF‐IR expression ranging from 1 to 14 ng/mg of lysate. Using flow cytometry the number of IGF‐IR surface receptors varied from >2,000 to 50,000 sites/cell. Cells expressing >10...

Transient receptor potential melastatin‐related 7 channel is overexpressed in human pancreatic ductal adenocarcinomas and regulates human pancreatic cancer cell migration

International Journal of Cancer — Fri, 10 Feb 2012 05:00:00 +0100

AbstractPancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive form of cancer with a tendency to invade surrounding healthy tissues, leading to a largely incurable disease. Despite many advances in modern medicine, there is still a lack of early biomarkers as well as efficient therapeutical strategies. The melastatin‐related transient receptor potential 7 channel (TRPM7) is a non‐selective cation channel which is involved in maintaining Ca2+ and Mg2+ homeostasis. It has been recently reported to regulate cell differentiation, proliferation and migration. However, the role of TRPM7 in PDAC progression is far to be understood. In the present study, we show that TRPM7 is 13‐fold overexpressed in cancer tissues compared to the healthy ones. Furthermore, TRPM7 staining is s...

Curry spice component may help slow prostate tumor growth

EurekAlert! - Medicine and Health — Fri, 10 Feb 2012 05:00:00 +0100

(Thomas Jefferson University) Curcumin, an active component of the Indian curry spice turmeric, may help slow down tumor growth in castration-resistant prostate cancer patients on androgen deprivation therapy, a study from researchers at Jefferson's Kimmel Cancer Center suggests. (Source: EurekAlert! - Medicine and Health)

Numeracy: The educational gift that keeps on giving?

EurekAlert! - Social and Behavioral Science — Fri, 10 Feb 2012 05:00:00 +0100

(Association for Psychological Science) Cancer risks. Investment alternatives. Calories. Numbers are everywhere in daily life, and they figure into all sorts of decisions. A new article published in Current Directions in Psychological Science, a journal of the Association for Psychological Science, examines how people who are numerate -- that's like literacy, but for numbers -- understand numbers better and process information differently so that they ultimately make more informed decisions. (Source: EurekAlert! - Social and Behavioral Science)

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Chemo During Pregnancy Doesn’t Seem to Harm Baby

The Doctors Lounge - Oncology — Fri, 10 Feb 2012 05:00:00 +0100

Study suggests treatment of expectant mothers is feasible after first trimester (Source: The Doctors Lounge - Oncology)

Germ cell DNA-repair systems—possible tools in cancer research?

Cancer Gene Therapy — Fri, 10 Feb 2012 05:00:00 +0100

Germ cell DNA-repair systems—possible tools in cancer research? Cancer Gene Therapy advance online publication, February 10, 2012. doi:10.1038/cgt.2012.1 Author: F Helle (Source: Cancer Gene Therapy)

PINCH is an independent prognostic factor in rectal cancer patients without preoperative radiotherapy - a study in a Swedish rectal cancer trial of preoperative radiotherapy

BMC Cancer — Fri, 10 Feb 2012 05:00:00 +0100

Conclusions: PINCH expression at the invasive margin was an independent prognostic factor in patients without RT. RT does not seem to directly affect the PINCH expression. (Source: BMC Cancer)

Oridonin induces apoptosis and senescence by increasing hydrogen peroxide and glutathione depletion in colorectal cancer cells.

International Journal of Molecular Medicine — Fri, 10 Feb 2012 04:43:41 +0100

In conclusion, the increase in hydrogen peroxide and glutathione depletion account for oridonin-induced apoptosis and senescence in colorectal cancer cells, and TrxR inhibition is involved in this process. Given the importance of TrxR as a novel cancer target in colon cancer, oridonin would be a promising clinical candidate. The mechanism of oridonin-induced inhibition of TrxR warrants further investigation. PMID: 22294162 [PubMed - in process] (Source: International Journal of Molecular Medicine)

Pattern of cancer/testis antigen expression in lung cancer patients.

International Journal of Molecular Medicine — Fri, 10 Feb 2012 04:43:31 +0100

Authors: Kim YD, Park HR, Song MH, Shin DH, Lee CH, Lee MK, Lee SY Abstract Cancer/testis (CT) antigens represent promising targets for immunotherapy. We investigated the composite expression of 13 CT antigens by RT-PCR in 79 lung cancer tissues and by immunohistochemistry in 22 lung cancer tissues. In the 79 lung cancer tissues, MAGE-3 (42%) was expressed most frequently and followed by NY-SAR-35 (33%), NY-ESO-1 (30%), MAGE-1 (27%), CT-7 (20%), MAGE-4 (19%), LAGE-1 (16%), and MAGE-10 (14%). Twenty-one tissues did not express any of the CT antigens tested, 58 (73%) expressed at least one, 36 (46%) co-expressed two, 24 (30%) co-expressed three, 17 (22%) co-expressed four, 14 (18%) co-expressed five, 8 (10%) co-expressed six, 4 (6%) co-...

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Evolving Standards of Care in Advanced Gastric CancerEvolving Standards of Care in Advanced Gastric Cancer

Medscape Today Headlines — Fri, 10 Feb 2012 04:00:00 +0100

What's the current state-of-the-art chemotherapy for advanced gastric cancer? Future Oncology (Source: Medscape Today Headlines)

Chemotherapy During Pregnancy Appears Safe for Offspring Chemotherapy During Pregnancy Appears Safe for Offspring

Medscape Today Headlines — Fri, 10 Feb 2012 01:31:01 +0100

Children exposed to chemotherapy during the prenatal period appear to develop as well as those in the general population, without increased cardiac or neurologic morbidity. Medscape Medical News (Source: Medscape Today Headlines)

New Attack on Alzheimer's

WSJ.com: Health — Fri, 10 Feb 2012 01:15:30 +0100

The skin-cancer drug bexarotene has improved mental and social ability and restored the sense of smell in mice bred with a form of Alzheimer's disease. (Source: WSJ.com: Health)

High-contrast mapping of basal cell carcinomas

Optics Letters — Fri, 10 Feb 2012 01:10:49 +0100

Because of low optical contrast in the visible spectral range, accurate detection of basal cell carcinomas (BCC) remains a challenging problem. In this letter, we experimentally demonstrate that reflectance confocal imaging in the vicinity of 1300 nm can be used for the detection of BCC without ... (Source: Optics Letters)

Chemo During Pregnancy Doesn't Seem to Harm Baby

MedlinePlus Health News — Fri, 10 Feb 2012 00:00:00 +0100

Study suggests treatment of expectant mothers is feasible after first trimester Source: HealthDay Related MedlinePlus Page: Cancer and Pregnancy (Source: MedlinePlus Health News)

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Cancer trial participants may have misconceptions

Reuters: Health — Thu, 09 Feb 2012 23:38:42 +0100

NEW YORK (Reuters Health) - People enrolled in early stage trials for possible cancer treatments may underestimate the risks involved and overestimate the potential benefits, suggests a new study. (Source: Reuters: Health)

Cancer Trial Participants May Have Misconceptions

MedlinePlus Health News — Thu, 09 Feb 2012 23:38:39 +0100

People enrolled in early stage trials for possible cancer treatments may underestimate the risks involved and overestimate the potential benefits, suggests a new study.Source: Reuters Health Related MedlinePlus Page: Clinical Trials (Source: MedlinePlus Health News)

Most women with cancer want a role in decisions

Reuters: Health — Thu, 09 Feb 2012 23:36:48 +0100

NEW YORK (Reuters Health) - About two-thirds of women diagnosed with early stage breast cancer want to take part in making decisions about their treatment, according to a new survey of patients from five different countries. (Source: Reuters: Health)

Most Women with Cancer Want a Role in Decisions

MedlinePlus Health News — Thu, 09 Feb 2012 23:36:45 +0100

About two-thirds of women diagnosed with early stage breast cancer want to take part in making decisions about their treatment, according to a new survey of patients from five different countries.Source: Reuters Health Related MedlinePlus Pages: Breast Cancer, Talking With Your Doctor (Source: MedlinePlus Health News)

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Bifidobacteriumanimalis subsp. lactis BB-12 Administration in Early Childhood: A Randomized Clinical Trial of Effects on Oral Colonization by Mutans Streptococci and the Probiotic

Karger Publishers — Thu, 09 Feb 2012 23:00:00 +0100

Caries Res 2012;46:69-77 (DOI:10.1159/000335567) (Source: Karger Publishers)

Ectopic Cilia:A Histopathological Study

Karger Publishers — Thu, 09 Feb 2012 23:00:00 +0100

Case Rep Dermatol 2012;4:37-40 (DOI:10.1159/000336887) (Source: Karger Publishers)

New Insight on the Response of Bacteria to Fluoride

Karger Publishers — Thu, 09 Feb 2012 23:00:00 +0100

Caries Res 2012;46:78-81 (DOI:10.1159/000336397) (Source: Karger Publishers)

The Impact of Magnification on Occlusal Caries Diagnosis with Implementation of the ICDAS II Criteria

Karger Publishers — Thu, 09 Feb 2012 23:00:00 +0100

Caries Res 2012;46:82-86 (DOI:10.1159/000335988) (Source: Karger Publishers)

DNMT Inhibitors and HDAC Inhibitors Regulate E-Cadherin and Bcl-2 Expression in Endometrial Carcinoma in vitro and in vivo

Chemotherapy — Thu, 09 Feb 2012 23:00:00 +0100

Chemotherapy 2012;58:19-29 (DOI:10.1159/000333077) (Source: Chemotherapy)

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Naturally Occurring Cutaneous Anthrax: Antibiotic Treatment and Outcome

Chemotherapy — Thu, 09 Feb 2012 23:00:00 +0100

Chemotherapy 2012;58:34-43 (DOI:10.1159/000335593) (Source: Chemotherapy)

Skin cancer drug reverses Alzheimer's in mice

CNN.com - Health — Thu, 09 Feb 2012 22:33:05 +0100

Scientists say they "serendipitously" discovered that a drug used to treat a type of cancer quickly reversed Alzheimer's disease in mice. (Source: CNN.com - Health)

Kidney Cancer News

Kidney Cancer Association — Thu, 09 Feb 2012 22:24:24 +0100

The February 2012 edition, anchored by Carrie Konosky, focuses on the many valuable contributions of kidney cancer researchers over the past two decades, as reflected in a keynote address to peers by W. Marston Linehan, MD. Bill Bro highlights FDA approval of a new drug to treat a certain type of kidney cancer and brings to light a controversial survey that suggests doctors aren't always forthright in dealing with patients. 02/10/2012 (Source: Kidney Cancer Association)

Cel-Sci looks for more funding

bizjournals.com Health Care:Hospitals headlines — Thu, 09 Feb 2012 22:23:41 +0100

Vienna-based Cel-Sci Corp., with final-stage clinical trials for its lead cancer drug underway, says it intends to find partners or other sources of funding to continue operations this year. Cel-Sci posted a net loss of $4.2 million, or 2 cents per share, in its fiscal first quarter, compared to a net loss of $6.3 million, or 3 cents per share, a year earlier as expenses for its Phase III clinical trials for Multikine slowed. Research and development costs fell to $2.5 million last quarter, compared to $3... (Source: bizjournals.com Health Care:Hospitals headlines)

Exelixis to sell 10M shares to pay for R&D, other expenses

bizjournals.com Health Care:Hospitals headlines — Thu, 09 Feb 2012 22:22:33 +0100

Cancer drug developer Exelixis Inc. plans to sell 10 million shares of common stock The South San Francisco-based company (NASDAQ: EXEL), which has centered its drug-development efforts around the cancer-fighting drug cabozantinib, said in a Securities and Exchange Commission filing Thursday that it will use net proceeds from the offering for research and development, capital expenditures, working capital and other purposes. The company expects to grant the underwriters a 30-day option to buy up to an addition 1... (Source: bizjournals.com Health Care:Hospitals headlines)

Cancer Drug Shows Promise for Alzheimer's

WSJ.com: Health — Thu, 09 Feb 2012 21:26:33 +0100

The skin-cancer drug bexarotene has improved mental and social ability and restored the sense of smell in mice bred with a form of Alzheimer's disease. (Source: WSJ.com: Health)

Need to Biopsy at Metastatic Breast Cancer Relapse?Need to Biopsy at Metastatic Breast Cancer Relapse?

Medscape Today Headlines — Thu, 09 Feb 2012 21:26:08 +0100

Taking a biopsy of metastatic cancer that has spread beyond the breast can lead to a change in systemic therapy, and thus management, in some patients, according to a prospective study. Medscape Medical News (Source: Medscape Today Headlines)

Bioinformatic and experimental fishing for artemisinin-interacting proteins from human nasopharyngeal cancer cells

RSC - Mol. BioSyst. latest articles — Thu, 09 Feb 2012 21:25:42 +0100

Mol. BioSyst., 2012, Advance ArticleDOI: 10.1039/C2MB05437J, PaperT. Eichhorn, S. Schloissnig, B. Hahn, A. Wendler, Rolf Mertens, W. D. Lehmann, R. L. Krauth-Siegel, T. EfferthThe anti-malarial artemisinin also exerts profound anti-cancer activity, but the mechanisms of action are incompletely understood. In the present investigation, we present a novel approach to identify artemisinin-interacting target proteins.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Mol. BioSyst. latest articles)

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Proteomic analysis in clear cell renal cell carcinoma: identification of differentially expressed protein by 2-D DIGE

RSC - Mol. BioSyst. latest articles — Thu, 09 Feb 2012 21:25:42 +0100

Mol. BioSyst., 2012, Advance ArticleDOI: 10.1039/C2MB05390J, PaperFrancesca Raimondo, Claudia Salemi, Clizia Chinello, Daniela Fumagalli, Lavinia Morosi, Francesco Rocco, Stefano Ferrero, Roberto Perego, Cristina Bianchi, Cecilia Sarto, Marina Pitto, Paolo Brambilla, Fulvio Magni2-D DIGE representation of 23 up- and 77 down-regulated proteins in RCC.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Mol. BioSyst. latest articles)

Silencing of tumor suppressor genes RASSF1A, SLIT2, and WIF1 by promoter hypermethylation in hereditary breast cancer

Molecular Carcinogenesis — Thu, 09 Feb 2012 21:17:58 +0100

AbstractPromoter hypermethylation is gaining strength as one of the main mechanisms through which tumor suppressor genes are silenced during tumor progression. Three tumor suppressor genes are frequently found methylated in their promoter, in concordance with absence of expression, RASSF1A, SLIT2, and WIF1. In addition, a previous array‐CGH analysis from our group showed that these genes are found in deleted genomic regions observed in hereditary breast cancer tumors. In the present work we analyzed the methylation status of these three tumor suppressor gene promoters in 47 hereditary breast cancer tumors. Promoter methylation status analysis of hereditary breast tumors revealed high methylation frequencies for the three genes (67% RASSF1A, 80% SLIT2, and 72% WIF1). Additionally, the pre...

Fast-track testing helps to find ovarian cancer early

CTV Health — Thu, 09 Feb 2012 20:11:34 +0100

Ovarian cancer has long been dubbed a silent killer because it's often diagnosed only when it's too late. But a Montreal oncologist is working on a better testing method and is encouraging women and their doctors not to ignore the early symptoms. (Source: CTV Health)

In Mice, Cancer Drug Shows Effect on Alzheimer’s Symptoms

The Doctors Lounge - Oncology — Thu, 09 Feb 2012 20:00:00 +0100

Early lab study showed reduction of disease-related plaque (Source: The Doctors Lounge - Oncology)

Heart Disease May Be Risk Factor for Prostate Cancer

The Doctors Lounge - Oncology — Thu, 09 Feb 2012 20:00:00 +0100

Study found men who had the first had 74% higher chance of developing the second (Source: The Doctors Lounge - Oncology)

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FDA panel rejects Eisai's leukemia drug

Reuters: Health — Thu, 09 Feb 2012 19:14:12 +0100

(Reuters) - An independent advisory panel to the U.S. health regulator said that Japanese drugmaker Eisai Co Ltd's Dacogen did not show a favorable risk-benefit profile to treat a type of blood cancer. (Source: Reuters: Health)

Dementia plaque 'rapidly cleared'

BBC News | Health | UK Edition — Thu, 09 Feb 2012 19:01:33 +0100

Destructive plaques found in the brains of Alzheimer's patients have been rapidly cleared by researchers testing a cancer drug on mice. (Source: BBC News | Health | UK Edition)

Skin cancer drug 'reverses Alzheimer's'

Telegraph Health — Thu, 09 Feb 2012 19:00:21 +0100

A drug commonly used to fight skin cancer could start to reverse Alzheimer's disease in a matter of hours, a laboratory study indicates. (Source: Telegraph Health)

In Mice, Cancer Drug Shows Effect on Alzheimer's Symptoms

MedlinePlus Health News — Thu, 09 Feb 2012 19:00:00 +0100

Early lab study showed reduction of disease-related plaque Source: HealthDay Related MedlinePlus Pages: Alzheimer's Disease, Cancer Chemotherapy (Source: MedlinePlus Health News)

Heart Disease May Be Risk Factor for Prostate Cancer

MedlinePlus Health News — Thu, 09 Feb 2012 19:00:00 +0100

Study found men who had the first had 74% higher chance of developing the secondSource: HealthDay Related MedlinePlus Pages: Heart Diseases, Prostate Cancer (Source: MedlinePlus Health News)

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Toxin-Based Targeted Therapy for Malignant Brain Tumors

Mediators of Inflammation — Thu, 09 Feb 2012 18:14:58 +0100

Despite advances in conventional treatment modalities for malignant brain tumors—surgery, radiotherapy, and chemotherapy—the prognosis for patients with high-grade astrocytic tumor remains dismal. The highly heterogeneous and diffuse nature of astrocytic tumors calls for the development of novel therapies. Advances in genomic and proteomic research indicate that treatment of brain tumor patients can be increasingly personalized according to the characteristics of the targeted tumor and its environment. Consequently, during the last two decades, a novel class of investigative drug candidates for the treatment of central nervous system neoplasia has emerged: recombinant fusion protein conjugates armed with cytotoxic agents targeting tumor-specific antigens. The clinical applicab...

Enhanced photocatalytic cytotoxic activity of Ag@Fe-doped TiO2 nanocomposites against human epithelial carcinoma cells

RSC - J. Mater. Chem. latest articles — Thu, 09 Feb 2012 17:44:28 +0100

J. Mater. Chem., 2012, Advance ArticleDOI: 10.1039/C2JM15636A, PaperMd. Abdulla-Al-Mamun, Yoshihumi Kusumoto, Md. Shariful IslamNewly synthesized Ag@Fe-doped TiO2 nanocomposites and their successful application for photocatalytic cancer cell killing under visible light irradiation were investigated.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - J. Mater. Chem. latest articles)

Synthesis of chitosan-coated near-infrared layered double hydroxide nanoparticles for in vivo optical imaging

RSC - J. Mater. Chem. latest articles — Thu, 09 Feb 2012 17:44:28 +0100

J. Mater. Chem., 2012, Advance ArticleDOI: 10.1039/C2JM16447G, PaperPei-Ru Wei, Shih-Hsun Cheng, Wei-Neng Liao, Kun-Che Kao, Ching-Feng Weng, Chia-Hung LeeThe chitosan-coated layered double hydroxide nanoparticles (LDHs)-indocyanine green samples have a high potential for the development of both organ-specific drug delivery systems and in vivo contrast agents for clinical cancer diagnosis and chemotherapy. LDHs coated with different amounts of chitosan showed a specific accumulation of nanoparticles in different target organs when injected intravenously.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - J. Mater. Chem. latest articles)

Denosumab for Delaying Bone Metastases Not Recommended Denosumab for Delaying Bone Metastases Not Recommended

Medscape Today Headlines — Thu, 09 Feb 2012 17:39:25 +0100

The new indication, aimed at men with castration-resistant prostate cancer, was not recommended for approval by an FDA advisory committee. Medscape Medical News (Source: Medscape Today Headlines)

Can Starch Harm Your Health?

Breast Cancer Chronicles — Thu, 09 Feb 2012 17:30:33 +0100

A study presented at the San Antonio Breast Cancer Conference in December confirmed that increasing the amount of starch in one’s diet, especially during the year following your diagnosis and (Source: Breast Cancer Chronicles)

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Fatal Adverse Events with Pazopanib, Sorafenib, SunitinibFatal Adverse Events with Pazopanib, Sorafenib, Sunitinib

Medscape Today Headlines — Thu, 09 Feb 2012 17:07:14 +0100

These targeted therapies represent a major step forward in the treatment of cancer, but are associated with fatal adverse events. Medscape Medical News (Source: Medscape Today Headlines)

Breast Cancer Death Risk Grows With Age

Health News from Medical News Today — Thu, 09 Feb 2012 17:00:00 +0100

A study in the February 8 edition of JAMA shows that postmenopausal women who suffer from hormone receptor-positive breast cancer have a higher death risk of breast cancer as they get older. Background information in the article states that: "Breast cancer is the leading contributor to cancer incidence and cancer mortality in women worldwide, with 1,383,500 new cases in 2008. In the United States in 2008, 41 percent of these women were aged 65 years or older at diagnosis... (Source: Health News from Medical News Today)

BRCA carriage improved epithelial ovarian cancer survival

HemOncToday.com — Thu, 09 Feb 2012 16:17:00 +0100

Bolton KL. JAMA. 2012;307:382-389. (Source: HemOncToday.com)

One-Pot Synthesis of Pyrrolidine-2-ones from Erythruronolactone and Amine

Journal of Cancer Epidemiology — Thu, 09 Feb 2012 16:00:39 +0100

Concise and accessible approaches to pyrrolidine-2-ones were studied. The synthesis involves the conversion of erythruronolactone to pyrrolidine-2-ones in good yields. (Source: Journal of Cancer Epidemiology)

Don't Kick the TKI (When EGFR+ Lung Cancer Progresses)Don't Kick the TKI (When EGFR+ Lung Cancer Progresses)

Medscape Today Headlines — Thu, 09 Feb 2012 15:54:31 +0100

When patients with EGFR-positive NSCLC progress, a change in therapy may be needed. But according to Dr. Mark Kris, the TKI should not be stopped. Find out why. Medscape Hematology-Oncology (Source: Medscape Today Headlines)

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Brentuximab: Effective but Use With Care!Brentuximab: Effective but Use With Care!

Medscape Today Headlines — Thu, 09 Feb 2012 15:47:38 +0100

Dr. Bruce Cheson discusses precautions to be observed when using brentuximab vedotin to treat lymphoma patients, in light of an FDA warning that its use carries risk for a rare but serious brain infection. Medscape Hematology-Oncology (Source: Medscape Today Headlines)

Earlier Diagnosis of HCC by MicroRNA Profiling?Earlier Diagnosis of HCC by MicroRNA Profiling?

Medscape Today Headlines — Thu, 09 Feb 2012 15:42:27 +0100

Diagnosis of early-stage HCC poses a clinical challenge. Dr. Alok Khorana reports on a study that suggests microRNA profiling could permit early diagnosis of this disease. Medscape Hematology-Oncology (Source: Medscape Today Headlines)

Development of small-molecule probes that selectively kill cells induced to express mutant RAS.

Bioorganic and Medicinal Chemistry Letters — Thu, 09 Feb 2012 15:20:29 +0100

Authors: Weïwer M, Bittker JA, Lewis TA, Shimada K, Yang WS, Macpherson L, Dandapani S, Palmer M, Stockwell BR, Schreiber SL, Munoz B Abstract Synthetic lethal screening is a chemical biology approach to identify small molecules that selectively kill oncogene-expressing cell lines with the goal of identifying pathways that provide specific targets against cancer cells. We performed a high-throughput screen of 303,282 compounds from the National Institutes of Health-Molecular Libraries Small Molecule Repository (NIH-MLSMR) against immortalized BJ fibroblasts expressing HRAS(G12V) followed by a counterscreen of lethal compounds in a series of isogenic cells lacking the HRAS(G12V) oncogene. This effort led to the identification of two novel molecular probes (PubChem CID 3689413, ML16...

[(11)C]GSK2126458 and [(18)F]GSK2126458, the first radiosynthesis of new potential PET agents for imaging of PI3K and mTOR in cancers.

Bioorganic and Medicinal Chemistry Letters — Thu, 09 Feb 2012 15:20:20 +0100

Authors: Wang M, Gao M, Miller KD, Sledge GW, Zheng QH Abstract GSK2126458 is a highly potent inhibitor of phosphoinositide 3-kinase (PI3K) and mammalian target of rapamycin (mTOR) with low picomolar to subnanomolar activity. [(11)C]GSK2126458 and [(18)F]GSK2126458, new potential PET agents for imaging of PI3K and mTOR in cancer, were first designed and synthesized in 40-50% and 20-30% decay corrected radiochemical yield, and 370-740 and 37-222GBq/μmol specific activity at end of bombardment (EOB), respectively. PMID: 22297110 [PubMed - in process] (Source: Bioorganic and Medicinal Chemistry Letters)

Eribulin is now available under national reimbursement in Italy for women with locally advanced or metastatic breast cancer

PharmacoEconomics and Outcomes News — Thu, 09 Feb 2012 14:54:20 +0100

(Source: PharmacoEconomics and Outcomes News)

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Neoadjuvant CRT prior to surgery cost effective for pancreatic cancer

PharmacoEconomics and Outcomes News — Thu, 09 Feb 2012 14:54:20 +0100

(Source: PharmacoEconomics and Outcomes News)

G-CSF cost-neutral for early-stage breast cancer

PharmacoEconomics and Outcomes News — Thu, 09 Feb 2012 14:54:20 +0100

(Source: PharmacoEconomics and Outcomes News)

Which cervical cancer screening interval and test is best?

PharmacoEconomics and Outcomes News — Thu, 09 Feb 2012 14:54:20 +0100

(Source: PharmacoEconomics and Outcomes News)

Cost-effective treatments for colorectal cancer

PharmacoEconomics and Outcomes News — Thu, 09 Feb 2012 14:54:20 +0100

(Source: PharmacoEconomics and Outcomes News)

Physicians Not Always Honest

Kidney Cancer Association — Thu, 09 Feb 2012 14:26:36 +0100

Doctors report that theyre not always completely honest with patients, especially when it comes to disclosing a medical mistake, or discussing a difficult prognosis, according to a new survey.02/09/2012 (Source: Kidney Cancer Association)

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Rare Phase 3 Salvage Trial in Relapsed Testicular CancerRare Phase 3 Salvage Trial in Relapsed Testicular Cancer

Medscape Today Headlines — Thu, 09 Feb 2012 13:18:31 +0100

Two approaches to high-dose salvage chemotherapy were compared in men with first-relapse testis cancer. Medscape Medical News (Source: Medscape Today Headlines)

Clinically relevant fatigue in men with hormone-sensitive prostate cancer on long-term androgen deprivation therapy

International Braz J Urol — Thu, 09 Feb 2012 12:58:42 +0100

CONCLUSION: Steady sphincter during both P and TDO, and occurrence of TDO appear as specific of aging. The last result could be related to structural changes in the detrusor muscle with aging. (Source: International Braz J Urol)

Prostate cancer in the elderly: frequency of advanced disease at presentation and disease-specific mortality

International Braz J Urol — Thu, 09 Feb 2012 12:58:42 +0100

Evolution of the clinical presentation of men undergoing radical prostatectomy for high-risk prostate cancer

International Braz J Urol — Thu, 09 Feb 2012 12:58:42 +0100

Characterization of small solid renal lesions: can benign and malignant tumors be differentiated with CT?

International Braz J Urol — Thu, 09 Feb 2012 12:58:42 +0100

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Controversies in using urine samples for prostate cancer detection: PSA and PCA3 expression analysis

International Braz J Urol — Thu, 09 Feb 2012 12:58:42 +0100

CONCLUSION: This work confirms that prostate massage is important before urine collection for gene expression analysis. Since PSA and PCA3 are prostate specific, it is necessary to promote the passage of cells from prostate to urinary tract, in order to detect these genetic markers in urine samples. (Source: International Braz J Urol)

Patients with a negative cystoscopy and negative Nmp22® Bladderchek® test are at low risk of missed transitional cell carcinoma of the bladder: a prospective evaluation

International Braz J Urol — Thu, 09 Feb 2012 12:58:42 +0100

CONCLUSIONS: In patients with negative cystoscopy and BladderChek, very few cancers are missed and cytology was not effective in detection. Use of a point-of-care test in conjunction with cystoscopy in lieu of cytology could decrease cost, provide immediate results, improve negative predictive value and reduce the uncertainty that results from inconclusive cytologic results. (Source: International Braz J Urol)

Cytoreductive Surgery Combined with Hyperthermic Intraperitoneal Intraoperative Chemotherapy in the Treatment of Advanced Epithelial Ovarian Cancer

Advances in Urology — Thu, 09 Feb 2012 12:58:14 +0100

Conclusions. Maximal cytoreductive surgery combined with HIPEC is a well-tolerated, feasible, and promising method of treatment in advanced ovarian cancer. (Source: Advances in Urology)

Hematopoietic Cell Transplant and Use of Massage for Improved Symptom Management: Results from a Pilot Randomized Control Trial

Advances in Urology — Thu, 09 Feb 2012 12:58:14 +0100

Discussion. Feasibility of studying massage-acupressure was established in children undergoing HCT. Larger studies are needed to test the efficacy of such interventions in reducing HCT-associated symptoms in children. (Source: Advances in Urology)

Reprogramming of prostate cancer‐associated stromal cells to embryonic stem‐like

The Prostate — Thu, 09 Feb 2012 12:55:08 +0100

CONCLUSIONSGenes of CP stromal cells could be fully inactivated by genetic reprogramming. As a consequence, the disease phenotype was ‘cured’. Prostate © 2012 Wiley Periodicals, Inc. (Source: The Prostate)

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Vaccine response augmented by lenalidomide in multiple myeloma

HemOncToday.com — Thu, 09 Feb 2012 12:54:00 +0100

Noonan K. Clin Cancer Res. 2012;doi:10.1158/1078-0432.CCR-11-1221. (Source: HemOncToday.com)

A case–control study of chronic prostatitis/chronic pelvic pain syndrome and colorectal cancer

BJU International — Thu, 09 Feb 2012 12:36:39 +0100

CONCLUSION• We conclude that CP/CPPS patients are at higher risk for CRC, especially in males under 60 years of age. (Source: BJU International)

Nigeria: FG to Upgrade 10 Cancer Centres

AllAfrica News: Health and Medicine — Thu, 09 Feb 2012 12:22:28 +0100

[Daily Trust] Lagos - Health Minister Professor Onyebuchi Chukwu said in Lagos yesterday that arrangements have been completed to upgrade 10 cancer centres across the country as part of efforts to curb the scourge of the disease. (Source: AllAfrica News: Health and Medicine)

UNFPA Joins the 'Hellosmile' Global Project to Prevent Cervical Cancer - 17 January 2012

UNFPA News — Thu, 09 Feb 2012 12:12:55 +0100

UNITED NATIONS, New York—UNFPA has joined Tokyo FM Radio and other Japanese partners, including the Japanese Ministry of Health, Labour and Welfare; Sanrio, maker of the popular 'Hello Kitty' doll; UNIQLO, the global clothing company; and Japan Airlines in the Hellosmile Project—a worldwide effort to prevent cervical cancer. (Source: UNFPA News)

Nigeria: FG to Upgrade 10 Cancer Centres

AllAfrica News: Health and Medicine — Thu, 09 Feb 2012 12:10:55 +0100

[This Day] Minister of Health, Professor Onyebuchi Chukwu, Wednesday said the Federal Government had completed plans to upgrade about 10 cancer centres in the country to meet the challenges posed by the scourge of the disease that had claimed several lives in the past few years. (Source: AllAfrica News: Health and Medicine)

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Nigeria: FG to Construct 10 Cancer Centres This Year

AllAfrica News: Health and Medicine — Thu, 09 Feb 2012 12:01:14 +0100

[Vanguard] Lagos - The Federal Government, yesterday, said it would construct 10 new cancer centres across the country in 2012, a measure to stem the high rate of the disease in the country. (Source: AllAfrica News: Health and Medicine)

Splenic Marginal Zone Lymphoma: Current Knowledge and Future Directions

Cancer Network — Thu, 09 Feb 2012 12:00:00 +0100

In this article, we review the current knowledge on the biological findings, clinical features, and therapeutic approaches for splenic marginal zone lymphoma. (Source: Cancer Network)

Splenic Lymphomas: Is There Still a Role for Splenectomy?

Cancer Network — Thu, 09 Feb 2012 12:00:00 +0100

Splenic lymphomas are a diverse group of lymphoid malignancies that have clinical behavior ranging from indolent to aggressive and that have both B-cell and T-cell histologies. (Source: Cancer Network)

Splenic Marginal Zone Lymphoma: Villous, Not Necessarily Villainous

Cancer Network — Thu, 09 Feb 2012 12:00:00 +0100

The article by Thieblemont and colleagues very nicely summarizes the key pathogenetic and diagnostic features and present treatment of splenic marginal zone lymphoma (SMZL). (Source: Cancer Network)

PARP Inhibition in Epithelial Ovarian Cancer: High Hopes Undergo a Reality Check

Cancer Network — Thu, 09 Feb 2012 12:00:00 +0100

This article reviews the trials that have been conducted with PARP inhibitors in epithelial ovarian cancer, fallopian tube cancer, and primary peritoneal cancer, and places the impact of those results in the larger context of PARP inhibitor development. (Source: Cancer Network)

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Immunoglobulin Light-Chain Amyloidosis: Growing Recognition, New Approaches to Therapy, Active Clinical Trials

Cancer Network — Thu, 09 Feb 2012 12:00:00 +0100

When light-chain amyloidosis is diagnosed prior to the development of advanced cardiomyopathy, systemic therapy is capable of producing hematologic responses that will translate into organ responses and prolonged survival. (Source: Cancer Network)

AL Amyloidosis: New Drugs and Tests, but Old Challenges

Cancer Network — Thu, 09 Feb 2012 12:00:00 +0100

Immunoglobulin light chain (AL) amyloidosis develops in 2% of individuals with monoclonal plasma cell dyscrasias. In this issue of ONCOLOGY, Drs. Gertz and Dispenzieri discuss AL amyloidosis, highlighting progress in the field along with outstanding challenges. (Source: Cancer Network)

New Testing for Lung Cancer Screening

Cancer Network — Thu, 09 Feb 2012 12:00:00 +0100

In this review, the authors discuss past attempts at lung cancer screening, the results of the National Lung Cancer Screening Trial, and innovative tests for lung cancer screening currently being evaluated. (Source: Cancer Network)

Formidable Challenges Ahead for Lung Cancer Screening

Cancer Network — Thu, 09 Feb 2012 12:00:00 +0100

Tanner et al provide a concise review of lung cancer screening, including discussion of past failed attempts, the success of the National Lung Screening Trial (NLST), and promising new avenues for improving on the NLST results. (Source: Cancer Network)

Lung Cancer Screening: A New Era

Cancer Network — Thu, 09 Feb 2012 12:00:00 +0100

Screening is always an issue that generates a great deal of emotion, as recently seen with the controversies surrounding mammography and prostate-specific antigen (PSA) testing. (Source: Cancer Network)

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Podcast: Dr. David Ahlquist on Advances in Colorectal Cancer Screening

Cancer Network — Thu, 09 Feb 2012 12:00:00 +0100

In this interview, Dr. David Ahlquist, gastroenterologist and professor of medicine at the Mayo Clinic in Rochester in Minnesota, discusses early detection methods of colorectal cancer, touching on sigmoidoscopy, colonoscopies, fecal blood testing, and in particular, stool DNA screening. (Source: Cancer Network)

The Maze of PARP Inhibitors in Ovarian Cancer

Cancer Network — Thu, 09 Feb 2012 12:00:00 +0100

The development of poly(ADP-ribose) polymerase (PARP) inhibitors as a new class of anticancer agents has created a tremendous amount of hope in the ovarian cancer community, especially in the high-risk, difficult-to-screen, hereditary ovarian cancer population. (Source: Cancer Network)

The Circuitous Path of PARP Inhibitor Development in Epithelial Ovarian Cancer

Cancer Network — Thu, 09 Feb 2012 12:00:00 +0100

Ovarian cancers account for more than 50% of gynecologic cancer deaths. This is attributable to the late stage of the disease at diagnosis. (Source: Cancer Network)

A novel infusible botanically-derived drug, PG2, for cancer-related fatigue: A phase II double-blind, randomized placebo-controlled study.

Clinical and Investigative Medicine — Thu, 09 Feb 2012 11:54:09 +0100

Conclusion: PG2 might be an effective and safe treatment for relieving CRF among advanced cancer patients. PMID: 22309959 [PubMed - in process] (Source: Clinical and Investigative Medicine)

Increased expression of CD55 correlates with tumor progression and poor prognosis in nasopharyngeal carcinoma.

Clinical and Investigative Medicine — Thu, 09 Feb 2012 11:54:09 +0100

Conclusion: The data from this study suggest, for the first time, that CD55 is frequently expressed in nasopharyngeal carcinoma and its expression is associated with decreased patient survival; therefore, CD55 expression may be a potential unfavorable prognostic factor for patients with nasopharyngeal carcinoma. PMID: 22309963 [PubMed - in process] (Source: Clinical and Investigative Medicine)

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Recurrence linked to high risk of subsequent events among triple-negative breast cancer patients

HemOncToday.com — Thu, 09 Feb 2012 11:43:00 +0100

Montagna E. Ann Oncol. 2012;23:324-331. (Source: HemOncToday.com)

Matricellular Proteins: A Sticky Affair with Cancers

Diagnostic and Therapeutic Endoscopy — Thu, 09 Feb 2012 11:02:10 +0100

The multistep process of metastasis is a major hallmark of cancer progression involving the cointeraction and coevolution of the tumor and its microenvironment. In the tumor microenvironment, tumor cells and the surrounding stromal cells aberrantly secrete matricellular proteins, which are a family of nonstructural proteins in the extracellular matrix (ECM) that exert regulatory roles via a variety of molecular mechanisms. Matricellular proteins provide signals that support tumorigenic activities characteristic of the metastastic cascade such as epithelial-to-mesenchymal (EMT) transition, angiogenesis, tumor cell motility, proliferation, invasion, evasion from immune surveillance, and survival of anoikis. Herein, we review the current understanding of the following matricellular proteins a...

Namibia: New Twist to Cancer Patient's Appear

AllAfrica News: Health and Medicine — Thu, 09 Feb 2012 10:55:19 +0100

[New Era] Windhoek - Thirteen-year-old Jade Abrahams who has a cancerous tumour is still in need of financial assistance for an operation despite recent claims by her mother who is divorced from her father that she does not need financial assistance. (Source: AllAfrica News: Health and Medicine)

Short Fasting Cycles Weaken Cancer In Mice; Can Work As Well As Chemotherapy, And The 2 Combined Greatly Improve Survival

Health News from Medical News Today — Thu, 09 Feb 2012 10:00:00 +0100

Man may not live by bread alone, but cancer in animals appears less resilient, judging by a study that found chemotherapy drugs work better when combined with cycles of short, severe fasting. Even fasting on its own effectively treated a majority of cancers tested in animals, including cancers from human cells. The study in Science Translational Medicine, part of the Science family of journals, found that five out of eight cancer types in mice responded to fasting alone: Just as with chemotherapy, fasting slowed the growth and spread of tumors... (Source: Health News from Medical News Today)

Treating Canine Lymphoma

Health News from Medical News Today — Thu, 09 Feb 2012 09:00:00 +0100

A new immunotherapy for companion dogs with advanced-stage non-Hodgkin lymphoma (NHL) has been shown to improve survival while maintaining quality of life, according to a study published in the journal Scientific Reports. The study resulted from a collaboration between The University of Texas MD Anderson Children's Cancer Hospital in Houston and Texas A&M University College of Veterinary Medicine in College Station... (Source: Health News from Medical News Today)

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Ovarian Cancer Risk Related To Inherited Inflammation Genes

Health News from Medical News Today — Thu, 09 Feb 2012 09:00:00 +0100

In a study conducted by researchers at Moffitt Cancer Center and colleagues from 11 other institutions in the Unites States and the United Kingdom, genes that are known to be involved in inflammation were found to be related to risk of ovarian cancer. Their study appeared in a recent issue of Cancer Research, published by the American Association for Cancer Research. Chronic inflammation is known to influence risk of several cancers, including ovarian cancer... (Source: Health News from Medical News Today)

Meetings Notice

Clinical Oncology — Thu, 09 Feb 2012 08:13:42 +0100

(Source: Clinical Oncology)

Clinical Outcomes of a Phase II Open-labelled, Randomised Study Investigating the Tolerability and Efficacy of Anti-androgen Manipulation versus Taxotere and Anti-androgen Manipulation in Patients with Hormone Naive High Risk/Metastatic Prostate Cancer

Clinical Oncology — Thu, 09 Feb 2012 08:13:42 +0100

Introduction: Androgen ablation (AA) is considered the standard initial therapy for men with high risk/metastatic prostate cancer. The role of chemotherapy and androgen ablation (TAA) is still undefined in this patient population. Here we present the clinical data from a phase II trial investigating clinical outcome and gene profiling of prostate cancer patients before and after AA or TAA. (Source: Clinical Oncology)

Radical Radiotherapy for Localised Hormone Refractory Prostate Cancer

Clinical Oncology — Thu, 09 Feb 2012 08:13:42 +0100

Introduction: Since PR07 and the Scandinavian Prostate Cancer Group showed survival benefit from adding radical radiotherapy (RT) to androgen deprivation therapy, prostate RT is routinely offered to fit patients with locally advanced prostate cancer [1,2]. Previously these patients were treated with hormones alone and followed up. Adding prostate RT when they become hormone refractory (and still have radiologically localised cancer) is controversial, but there is some evidence that patients with locally advanced hormone refractory prostate cancer (HRPC) may benefit [3]. The natural history of non-metastatic HRPC is unknown and treatment options are limited. Metastatic HRPC is associated with poor prognosis; widely quoted survival being 12–18 months, which with PSA lead time may be an und...

Analysis of Malignant Spinal Cord Compression Patients treated in a Regional Neuro-oncology Centre

Clinical Oncology — Thu, 09 Feb 2012 08:13:42 +0100

Introduction: Since December 2009 there has been a spinal cord compression coordinator in the Lancashire and Cumbria cancer network to enable patients to receive care as per NICE 2008 guidelines [1]. We conducted a retrospective analysis of patient management between December 2009 and January 2011 and reviewed survival outcomes. (Source: Clinical Oncology)

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Intensity Modulated Radiotherapy (IMRT) in the Treatment of Pelvic Lymph Nodes in Locally Advanced Prostate Cancer (LAPCa): a Single UK Institution Experience

Clinical Oncology — Thu, 09 Feb 2012 08:13:42 +0100

Introduction: Evidence is in favour of localised radiotherapy in the treatment of LAPCa. Whether there is added disease control by including the pelvic lymph nodes in the irradiation volume is less clear. This paper describes our experience in using IMRT to treat the pelvic nodes in this patient population. (Source: Clinical Oncology)

Sunitinib Malate in the Treatment of Metastatic Renal Cell Carcinoma: the North of England Cancer Network (NECN) Experience

Clinical Oncology — Thu, 09 Feb 2012 08:13:42 +0100

Introduction: Metastatic renal cell carcinoma (mRCC) has a poor prognosis. Treatment aims to improve progression free survival (PFS) and overall survival (OS). Sunitinib gained NICE approval in March 2009 as first line treatment and experience with it is growing. The NECN was the first in the UK to approve the use of Sunitinib in July 2007. This retrospective re-audit compares the NECN patient outcomes with published literature, updating previous NECN work from 2008. (Source: Clinical Oncology)

Multi-institutional Outcome Following LDR Brachytherapy in Patients with Higher Risk Prostate Cancer

Clinical Oncology — Thu, 09 Feb 2012 08:13:42 +0100

We report the outcomes for a cohort of men with higher risk prostate adenocarcinoma treated with LDR brachytherapy in a multi-institutional UK practice. Materials and methods: 217 men treated between 2003 and 2007 with iodine-125 brachytherapy at Christie, Leeds and Mount Vernon were identified from a multi-institutional database. Higher risk was defined as patients with≥2 D'Amico intermediate risk factors (PSA 10–20, GS 7 or clinical T2c) or ≥1 high risk factor (PSA>20, GS≥8). Kaplan–Meier methods were used to estimate biochemical relapse free survival (BRFS) defined using both Phoenix and ASTRO definitions. A univariate analysis was performed to assess the significance of Gleason score, PSA, T-stage, pre- or post-implant dosimetry, and additional hormones on BRFS. (Source: Cli...

Acute Toxicity Rates in Patients Receiving Salvage Radical Prostate Irradiation Following Primary High Intensity Focused Ultrasound (HIFU) for Localised Prostate Cancer

Clinical Oncology — Thu, 09 Feb 2012 08:13:41 +0100

We present a case series reporting acute radiotherapy toxicity in patients treated with primary HIFU. (Source: Clinical Oncology)

Pelvic External Beam Radiotherapy and High Dose Rate Image Guided Interstitial Brachytherapy Boost for High Risk Prostate Cancer

Clinical Oncology — Thu, 09 Feb 2012 08:13:41 +0100

Introduction: Evaluation of pelvic nodal external beam radiotherapy (EBRT) with interstitial high dose rate brachytherapy (HDRB) boost to prostate and seminal vesicles for high risk prostate adenocarcinoma. (Source: Clinical Oncology)

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Single Fraction HDR Boost and Dose Escalation for Intermediate and High Risk Prostate Cancer. A Report of Toxicity from a Single Centre Experience

Clinical Oncology — Thu, 09 Feb 2012 08:13:41 +0100

We report our experience of medium-term toxicities following HDR brachytherapy as a single fraction boost of 12.5Gy or 15Gy prior to EBRT. (Source: Clinical Oncology)

The Role of mp-MRI in the Detection of Prostate Cancer

Clinical Oncology — Thu, 09 Feb 2012 08:13:41 +0100

We present a preliminary analysis of a paired dataset in which mp-MRI was applied prior to a 5mm 3D template prostate mapping (TPM) in men at risk. (Source: Clinical Oncology)

PET with FDG May Predict Outcomes in Triple-Negative Breast Cancer

Diagnostic Imaging — Thu, 09 Feb 2012 08:00:02 +0100

Positron emission tomography with 18F-FDG during chemotherapy can help predict a patient’s response to therapy. (Source: Diagnostic Imaging)

CD97 Gene Expression And Function Correlate With WT1 Protein Expression And Glioma Invasiveness

Health News from Medical News Today — Thu, 09 Feb 2012 08:00:00 +0100

Researchers at Virginia Commonwealth University Medical Center's VCU Massey Cancer Center and Harold F. Young Neurosurgical Center (Richmond, VA) and Old Dominion University (Norfolk, VA) have discovered that suppression of Wilms tumor 1 protein (WT1) results in downregulation of CD97 gene expression in three glioblastoma cell lines and reduces the characteristic invasiveness exhibited by glial tumor cells... (Source: Health News from Medical News Today)