MedWorm: Penile Cancer

Op3-11 inguinal lymphadenectomy in penile cancer: results from the national cancer database

The Journal of Urology — Tue, 01 Apr 2014 00:00:00 +0100

(Source: The Journal of Urology)

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V7-07 robotic bilateral inguinal lymphadenectomy in penile cancer, without robot repositioning

The Journal of Urology — Tue, 01 Apr 2014 00:00:00 +0100

(Source: The Journal of Urology)

Mp10-19 development and external validation of a prognostic tool for prediction of cancer-specific mortality after complete loco-regional pathological staging for squamous cell carcinoma of the penis

The Journal of Urology — Tue, 01 Apr 2014 00:00:00 +0100

(Source: The Journal of Urology)

Mp10-18 peri-operative combination of cisplatin and 5-fluorouracil plus a taxane in patients undergoing lymph-node dissection for nodal metastases from squamous cell carcinoma (scc) of the penis: is adjuvant therapy better?

The Journal of Urology — Tue, 01 Apr 2014 00:00:00 +0100

(Source: The Journal of Urology)

Mp10-17 immunohistochemical expression of the insulin-like growth factor-1 receptor in squamous cell carcinomas of the penis

The Journal of Urology — Tue, 01 Apr 2014 00:00:00 +0100

(Source: The Journal of Urology)

Mp10-16 18f-fdg pet/ct as a predictor of invasiveness in penile cancer patients: correlation with pathology

The Journal of Urology — Tue, 01 Apr 2014 00:00:00 +0100

(Source: The Journal of Urology)

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Mp10-15 dynamic sentinel lymph node biopsy in penile cancer: a single centre experience

The Journal of Urology — Tue, 01 Apr 2014 00:00:00 +0100

(Source: The Journal of Urology)

Mp10-14 predicting inguinal and pelvic lymph node status in penile cancer patients: a comparison of computed tomography and disease burden of inguinal lymph nodes

The Journal of Urology — Tue, 01 Apr 2014 00:00:00 +0100

(Source: The Journal of Urology)

Mp10-13 obesity increases the risk of invasive penile cancer

The Journal of Urology — Tue, 01 Apr 2014 00:00:00 +0100

(Source: The Journal of Urology)

Mp10-10 surgical management of testicular cancer patients with complex postchemotherapy residual masses: single centre experience

The Journal of Urology — Tue, 01 Apr 2014 00:00:00 +0100

(Source: The Journal of Urology)

Mp10-05 influence of race on outcomes in testicular cancer: analysis of 75902 patients in the national cancer data base

The Journal of Urology — Tue, 01 Apr 2014 00:00:00 +0100

(Source: The Journal of Urology)

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Mp10-04 characteristics of certifying urologists performing retroperitoneal lymph node dissections for testis cancer in the united states

The Journal of Urology — Tue, 01 Apr 2014 00:00:00 +0100

(Source: The Journal of Urology)

Mp10-03 the influence of access to care on adherence to clinical practice guidelines for testis cancer

The Journal of Urology — Tue, 01 Apr 2014 00:00:00 +0100

(Source: The Journal of Urology)

Mp10-01 stromal testicular tumors exhibit worse cancer-specific survival compared to germ cell testicular tumors in all stage categories

The Journal of Urology — Tue, 01 Apr 2014 00:00:00 +0100

(Source: The Journal of Urology)

Pd5-12 predictors of cancer-specific mortality after disease recurrence in patients with squamous cell carcinoma of the penis

The Journal of Urology — Tue, 01 Apr 2014 00:00:00 +0100

(Source: The Journal of Urology)

Pd5-10 overtreatment of low stage penile cancer in the united states

The Journal of Urology — Tue, 01 Apr 2014 00:00:00 +0100

(Source: The Journal of Urology)

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Pd5-09 salvage surgical resection for locally recurrent inguinal metastasis of penile cancer: an international, multicenter collaborative experience

The Journal of Urology — Tue, 01 Apr 2014 00:00:00 +0100

(Source: The Journal of Urology)

Pd5-08 contemporary outcomes of inguinal lymph node dissection for penile cancer in a multicenter international cohort

The Journal of Urology — Tue, 01 Apr 2014 00:00:00 +0100

(Source: The Journal of Urology)

Pd5-06 retrocrural dissection during retroperitoneal lymph node dissection for testicular cancer

The Journal of Urology — Tue, 01 Apr 2014 00:00:00 +0100

(Source: The Journal of Urology)

Pd5-05 surgical management of retrocrural disease in testis cancer: outcomes and evolution of practice

The Journal of Urology — Tue, 01 Apr 2014 00:00:00 +0100

(Source: The Journal of Urology)

Pd5-04 united states trends in patterns of care in clinical stage i testicular cancer: results from the national cancer data base (1998-2011)

The Journal of Urology — Tue, 01 Apr 2014 00:00:00 +0100

(Source: The Journal of Urology)

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Pd5-03 regionalization in treatment of penile cancer among american urologists

The Journal of Urology — Tue, 01 Apr 2014 00:00:00 +0100

(Source: The Journal of Urology)

Pd5-02 the impact of lack of insurance on testicular cancer prognosis in young patients in the united states. data from the seer data base

The Journal of Urology — Tue, 01 Apr 2014 00:00:00 +0100

(Source: The Journal of Urology)

Pd5-01 contemporary retroperitoneal lymph node dissection (rplnd) for testis cancer in the uk - a national study

The Journal of Urology — Tue, 01 Apr 2014 00:00:00 +0100

(Source: The Journal of Urology)

Penile tumours: a review

Journal of the European Academy of Dermatology and Venereology — Mon, 31 Mar 2014 10:17:30 +0100

Abstract Penile tumours are an important problem of male health affecting physical, mental and sexual health. Penile tumours can be subdivided into benign and malignant lesions. Their knowledge is important to prevent mutilating surgery in benign lesions. On the other hand, early recognition of malignancies is important for improved prognosis, and preservation of function. The most important tumour by epidemiology and prognosis is penile cancer. In contrast, malignant melanoma, sarcomas and lymphomas are rare. Clinical symptoms, histopathology and treatment options are discussed. Best possible treatment needs an interdisciplinary approach. (Source: Journal of the European Academy of Dermatology and Venereology)

Extramammary Paget's disease: Analysis of 17 Chinese cases

Indian Journal of Dermatology, Venereology and Leprology — Wed, 26 Mar 2014 00:00:00 +0100

Conclusion: A striking difference in presentation of EMPD in Chinese compared with Caucasians is the male predominance and location on the penis and scrotum. Mohs micrographic surgery followed by radiotherapy is an effective treatment. Long-term follow-up suggests that the disease has a good prognosis when it does not metastasise. (Source: Indian Journal of Dermatology, Venereology and Leprology)

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Penis Cancer

MedicineNet Cancer General — Tue, 18 Mar 2014 07:00:00 +0100

Title: Penis CancerCategory: Diseases and ConditionsCreated: 5/5/1999 7:28:00 AMLast Editorial Review: 3/18/2014 12:00:00 AM (Source: MedicineNet Cancer General)

Case of giant basal cell carcinoma around the base of the penis in an elderly patient

The Journal of Dermatology — Sat, 15 Mar 2014 00:00:00 +0100

We report a case of an 85‐year‐old man with a doughnut‐shaped basal cell carcinoma around the base of the penis invading the cavernosum urethra. In cases in which curative resection is planned, the penis is resected, cystostomy is performed, and postoperative self‐management is required. In line with the patient's wishes and the fact that he was an elderly person living alone without family support, we decided to perform penis‐conserving surgery. Relapse occurred once, for which additional resection was conducted. Two years after the resection, there was no evidence of tumor recurrence. The therapeutic plan for elderly patients should be modified after considering the patient's social background, wishes, activity and life expectancy. (Source: The Journal of Dermatology)

Genital prevalence of HPV types and co-infection in men

International Braz J Urol — Fri, 14 Mar 2014 14:37:28 +0100

Conclusion: The most frequent HPV types were 6, 16, 42 and 51. Co-infection was found in 59% of our patients. This information is vital to drive future public health policies including massive public vaccination campaign. (Source: International Braz J Urol)

Holmium laser endourethrotomy for the treatment of long-segment urethral strictures: a retrospective study of 190 patients.

Urology Journal — Mon, 10 Mar 2014 05:20:02 +0100

Conclusion: Holmium laser endourethrotomy with the poking maneuver is a therapeutically effective and minimally invasive treatment for LSUS. PMID: 24595935 [PubMed - in process] (Source: Urology Journal)

Salvage Surgical Resection for Isolated Locally Recurrent Inguinal Lymph Node Metastasis of Penile Cancer: International Study Collaboration

The Journal of Urology — Mon, 03 Mar 2014 00:00:00 +0100

(Source: The Journal of Urology)

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[Evaluation of hypnosis in pain management during photodynamic therapy: A pilot study].

Annales de Dermatologie et de Cenereologie — Sat, 01 Mar 2014 00:00:00 +0100

DISCUSSION: Hypnoanalgesia appears to be of value for pain management with PTD. This method is simple, inexpensive and devoid of side effects, and it is active on both pain and anxiety. To improve the use of hypnoanalgesia in PDT, it would be necessary to have better knowledge of the predictive factors for pain in PDT, to determine how to best select patients "sensitive" to hypnosis, and to encourage the training of nurses and doctors in this method. PMID: 24635951 [PubMed - in process] (Source: Annales de Dermatologie et de Cenereologie)

Masculinities, humour and care for penile cancer: a qualitative study

Journal of Advanced Nursing — Tue, 25 Feb 2014 17:13:34 +0100

ConclusionThe findings suggest a combination of functionalist, relief and incongruity theories of humour; the emotions these men experience are contained (functionalist) and released (relief) through humorous interaction, and the potential for comedy lies in an incongruity between what is expected socially and the experiences of these men, for example, around expectations that men use urinals in public toilets. Nurses should continue to use humour to build rapport with patients, should they judge this to be appropriate, although they may want to avoid jokes about sexual and urinary functioning until after treatment. (Source: Journal of Advanced Nursing)

Human papillomavirus status in extragenital nonmelanoma skin cancers

Clinics in Dermatology — Fri, 21 Feb 2014 20:59:19 +0100

Abstract: About 5% of all cancers worldwide can be attributed to human papillomaviruses (HPVs); namely, six sites are strongly associated with HPV infections: cervix, penis, vulva, vagina, anus, and oropharynx. Nonmelanoma skin cancers (NMSC), basal cell carcinoma (BCC), and squamous cell carcinoma (SCC) are the most common malignancies in Caucasians. In fact, there is an intense connection between sunlight exposure, fair skin, HPV, and development of NMSC. We have conducted a pilot study that included tissue samples from 26 carcinoma patients, of which there were 13 BCC and 13 SCC. HPV detection and typing was done with DNA amplification and sequencing, respectively. In total, 23.1% of SCC samples (3/13) and 7.7% of BCC samples (1/13) were positive for HPV DNA. The importance of understan...

HPV-associated diseases

Clinics in Dermatology — Fri, 21 Feb 2014 20:59:18 +0100

Abstract: Nearly 200 distinct human papilloma viruses (HPVs) have now been recognized, and each is associated with a specific set of clinical lesions. They are associated with a spectrum of diseases, from benign verrucae vulgares and condylomata acuminata to the malignancies of the cervix, vulva, anus, and penis. Disease associated with HPV can be divided into skin and mucosal lesion of the genital and extragenital regions. The relationship between HPV and nonmelanoma skin cancer (NMSC) is important clinically, because NMSC is the most common form of malignancy among fair-skinned populations. HPVs have also been detected in skin tags, lichen sclerosus, seborrheic keratoses, actinic keratoses, epidermal cysts, psoriatic plaques, and plucked hairs, but cutaneous HPV can be found on healthy s...

20% rise in penile cancer: are STIs to blame?

NHS News Feed — Wed, 19 Feb 2014 11:48:00 +0100

Conclusion This study found that the incidence of penile cancer increased by 20% from 1979 to 2009; however, it fluctuated during the period. For example, the incidence in 2008 was the same as in 1980, although the overall trend is that of an increase. The study does not prove the causes of this increase, but the most important factors known to increase the risk include: smoking human papilloma virus (which causes warts) However, it is also possible that the increased incidence of penile cancer is due simply to more people being diagnosed. The apparent good news is that the proportion of men surviving for at least a year increased from 76.2% to 87.1%, and five-year survival increased from 61.4% to 70.2%. As the researchers point out, this may have been due to the “advancement of diagn...

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Development and external validation of a prognostic tool for prediction of cancer‐specific mortality after complete loco‐regional pathological staging for squamous cell carcinoma of the penis

BJU International — Wed, 19 Feb 2014 00:00:00 +0100

ConclusionsThe newly developed model integrates important prognostic factors, which existing models do not consider. Its performance was highly accurate using measures of discrimination and calibration. (Source: BJU International)

Penis cancer cases soar amidst fears symptoms are misdiagnosed as STDs

the Mail online | Health — Tue, 18 Feb 2014 15:31:48 +0100

Risk factors for the disease include the human papilloma virus (HPV), also linked to cervical and oral cancer, smoking and not being circumcised, says cancer charity Orchid. (Source: the Mail online | Health)

The Clinical Spectrum of Lichen Sclerosus in Male Patients - A Retrospective Study.

Acta Dermato-Venereologica — Tue, 18 Feb 2014 00:00:00 +0100

Authors: Kantere D, Löwhagen GB, Alvengren G, Månesköld A, Gillstedt M, Tunbäck P Abstract Lichen sclerosus (LS) is a chronic dermatosis mainly localised to the anogenital area. The aim of this study was to investigate the clinical features of LS in adult men. A retrospective analysis of records from 771 patients diagnosed with LS was made and a questionnaire was sent to all patients. The results showed that the clinical spectrum was wide. Itch, tenderness and pain were frequently reported and more than half of the patients reported that LS had a negative impact on their sexual health. Phimosis was common and almost 1/3 of the patients were circumcised before or during the study period. Eight cases (1%) of penile squamous cell carcinoma were recorded. This emphasises the need f...

Giant condyloma acuminatum of Buschke–Lowenstein tumour: Disease development between 2000 and 2010

Surgical Practice — Mon, 17 Feb 2014 00:00:00 +0100

ConclusionsOur research found that there were more viral studies on specimens in order to understand the disease, and a less transformation rate to malignancy was found. Surgery is still the preferred practice for treating patients. (Source: Surgical Practice)

Does the width of the surgical margin of safety or premalignant dermatoses at the negative surgical margin affect outcome in surgically treated penile cancer?

Journal of Clinical Pathology — Fri, 14 Feb 2014 00:00:00 +0100

Conclusions SH, LS and dPeIN are frequent histological findings at the NSM of surgically treated PSC. However, neither the width of the NSM nor dPeIN, LS or SH at the NSM influences prognostic outcome. (Source: Journal of Clinical Pathology)

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Sixteen years post radiotherapy of nasopharyngeal carcinoma elicited multi-dysfunction along PTX and chronic kidney disease with microcytic anemia

BMC Urology - Latest articles — Wed, 12 Feb 2014 00:00:00 +0100

Background: The hypothalamic-pituitary (h-p) unit is a particularly radiosensitive region in the central nervous system. As a consequence, radiation-induced irreversible, progressively chronic onset hypopituitarism (RIH) commonly develops after radiation treatments and can result in variably impaired pituitary function, which is frequently associated with increased morbidity and mortality.Case presentationA 38-year-old male subject, previously having received radiotherapy for treatment of nasopharygeal carcinoma (NPCA) 16 years ago, appeared at OPD complaining about his failure in penile erection, loss of pubic hair, atrophy of external genitalia: testicles reduced to 2x1.5 cm; penile size shrunk to only 4 cm long. Characteristically, he showed extremely lowered human growth hormone, (HGH,...

President's Panel Calls for More Girls, Boys to Get HPV Vaccine

MedlinePlus Health News — Mon, 10 Feb 2014 17:00:00 +0100

It protects against cancers of the cervix, throat, rectum and penis, but too few getting the shots Source: HealthDay Related MedlinePlus Pages: HPV, Immunization, Teen Health (Source: MedlinePlus Health News)

President’s Panel Calls for More Girls, Boys to Get HPV Vaccine

The Doctors Lounge - Oncology — Mon, 10 Feb 2014 00:00:00 +0100

It protects against cancers of the cervix, throat, rectum and penis, but too few getting the shots (Source: The Doctors Lounge - Oncology)

President's Panel Calls for More Girls, Boys to Get HPV Vaccine

Cancercompass News: Gynecological Cancer — Mon, 10 Feb 2014 00:00:00 +0100

It protects against cancers of the cervix, throat, rectum and penis, but too few getting the shots (Source: Cancercompass News: Gynecological Cancer)

Re: Radical Open Inguinal Lymphadenectomy for Penile Carcinoma: Surgical Technique, Early Complications and Late Outcomes

The Journal of Urology — Mon, 10 Feb 2014 00:00:00 +0100

(Source: The Journal of Urology)

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The latest information on Macrolane™: Its indications and restrictions.

Annales de Chirurgie Plastique et Esthetique — Wed, 05 Feb 2014 00:00:00 +0100

CONCLUSIONS: Present-day scientific data fail to justify the market reappearance of Macrolane™ breast augmentation products. Q-Med has shown full awareness of the problem by imposing worldwide restrictions on products aimed at penis as well as breast enlargement. Larger cohorts of female patients are more necessary than ever, as is an approach based on stepping back and taking stock. PMID: 24507861 [PubMed - as supplied by publisher] (Source: Annales de Chirurgie Plastique et Esthetique)

Penile primary melanoma: analysis of 6 patients treated at Brazilian national cancer institute in the last eight years

International Braz J Urol — Mon, 03 Feb 2014 04:17:09 +0100

Conclusion: Penile melanoma is a disease with poor prognosis in most cases. Local excision or partial penile amputation may have effective control for stages T1 and T2 lesions. Patients who have clinically proven metastases died despite surgical and adjuvant chemotherapy. (Source: International Braz J Urol)

Expanded criteria for Video Endoscopic Inguinal Lymphadenectomy (VEIL) in penile cancer: palpable lymph nodes

International Braz J Urol — Mon, 03 Feb 2014 04:17:09 +0100

Conclusions VEIL is a safe complementary procedure for treatment of PC, even in patients with PILN. Oncological results in patients with PILN seem to be appropriate but are still very premature. Prospective multicenter studies with larger samples and long-term follow-up should be conducted to determine the oncological equivalence of VEIL compared with open surgery in patients with PILN. (Source: International Braz J Urol)

Single Center Outcomes after Reconstructive Surgical Correction of Adult Acquired Buried Penis: Measurements of Erectile Function, Depression, and Quality of Life

The Journal of Sexual Medicine — Sat, 01 Feb 2014 00:00:00 +0100

ConclusionsManagement of adult acquired buried penis is a challenging, yet correctable problem. In our series it appears that by using established surgical techniques we were able to achieve significant improvements in erectile function, QOL, and measures of depression. Rybak J, Larsen S, Yu M, and Levine LA. Single center outcomes after reconstructive surgical correction of adult acquired buried penis: measurements of erectile function, depression, and quality of life. J Sex Med **;**:**–**. (Source: The Journal of Sexual Medicine)

Prognostic significance of the degree of extranodal extension in patients with penile carcinoma.

Asian Journal of Andrology — Tue, 28 Jan 2014 00:00:00 +0100

In conclusion, patients with ENE have a poor outcome, and ENE grade 2 is an independent predictive factor of poor OS in patients with pathological ENE penile carcinoma. PMID: 24480925 [PubMed - as supplied by publisher] (Source: Asian Journal of Andrology)

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Penile metastasis secondary to bladder cancer: A report of two cases

Indian Journal of Palliative Care — Tue, 21 Jan 2014 05:00:00 +0100

Narendra Kumar, Tapesh Bhattacharyya, AK Mandal, Nalini Gupta, A Rajwanshi, Ritesh KumarIndian Journal of Palliative Care 2014 20(1):57-60Penile metastasis secondary to primary bladder cancer is a rare entity and represents a challenging problem. The common mode of spread to the penis is by retrograde venous route. The overall outcome is dismal and most patients will die within 1 year even after optimum treatment. Here, we report two such cases. (Source: Indian Journal of Palliative Care)

Management of Advanced Primary Urethral Carcinomas

BJU International — Tue, 21 Jan 2014 05:00:00 +0100

Abstract Primary urethral carcinoma (PUC) is a rare malignancy accounting for less than 1% of genitourinary cancers, with a predilection for men and African Americans. The sites and histology of urethral carcinoma vary by gender and anatomic location. Squamous cell carcinoma is most common among both genders but adenocarcinomas are noted in 15% to 35% of cases among women. Obstructive or irritative symptoms and hematuria are common modes of presentation. Clinical evaluation includes cystourethroscopy with biopsy and examination under anesthesia. Magnetic resonance imaging provides a highly effective method to image the primary tumor while defıning the potential involvement of surrounding structures. Most tumors are localized, with regional metastases to nodal sites seen in up to 30% of ca...

Should centralized histopathological review in penile cancer be the global standard?

BJU International — Wed, 15 Jan 2014 05:00:00 +0100

Conclusions In the present study a significant proportion of penile cancer histology reports were revised after review by the Sn‐MDT. Many of these changes altered patient management. The present study shows that accurate pathological diagnosis plays a crucial role in determining the correct treatment and maximizing the potential for good clinical outcomes in penile cancer. In the case of histopathology, centralization has increased exposure to penile cancer and thereby increased diagnostic accuracy, and should therefore be considered the ‘gold standard’. (Source: BJU International)

Morning Break: No Penis Pump Bargains, Blogging Cancer

MedPage Today Hematology/Oncology — Tue, 14 Jan 2014 14:13:04 +0100

(MedPage Today) -- Health news and commentary from around the Web, gathered by the MedPage Today staff. (Source: MedPage Today Hematology/Oncology)

Update on Vaccination Clinical Trials for HPV-Related Disease.

Clinical Therapeutics — Wed, 01 Jan 2014 05:00:00 +0100

CONCLUSIONS: Future directions include development of more affordable vaccines with extended HPV-type coverage as well as implementation of feasible worldwide vaccination programs. PMID: 24417781 [PubMed - in process] (Source: Clinical Therapeutics)

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Current and proposed molecular diagnostics in a genitourinary service line laboratory at a tertiary clinical institution.

Cancer Journal — Wed, 01 Jan 2014 05:00:00 +0100

Authors: Udager AM, Alva A, Mehra R Abstract The idea that detailed knowledge of molecular oncogenesis will drive diagnostic, prognostic, and therapeutic clinical decision making in an increasingly multidisciplinary practice of oncologic care has been anticipated for many years. With the recent rapid advancement in our understanding of the molecular underpinnings of genitourinary malignancies, this concept is now starting to take shape in the fields of prostate, kidney, bladder, testicular, and penile cancer. Such breakthroughs necessitate the development of robust clinical-grade assays that can be quickly made available for patients to facilitate diagnosis in challenging cases, risk-stratify patients for subsequent clinical management, select the appropriate targeted therapy from ...

Penile necrosis requiring penectomy complicating recto-urethral fistula post prostate cancer external beam radiation and brachytherapy.

Canadian Urological Association Journal — Wed, 01 Jan 2014 05:00:00 +0100

We report a case of a recto-urethral fistula 7 years post-external beam radiation and I-125 brachytherapy, which was complicated by a severe polymicrobial soft tissue infection. This infection required penectomy and pelvic exenteration with diverting colostomy, Indiana pouch urinary diversion and gracilis myo-cutaneuos flap closure of the perineum. PMID: 24454604 [PubMed] (Source: Canadian Urological Association Journal)

Engaging men with penile cancer in qualitative research: reflections from an interview-based study.

Nurse Researcher — Wed, 01 Jan 2014 00:00:00 +0100

Conclusion Engaging men with penile cancer in qualitative interview raises practical, methodological, ethical and emotional challenges for the researcher. However, when these challenges are met, men will talk about their health. Methodological procedures must enable an open and ongoing dialogue with clinical gatekeepers and potential participants to promote engagement. Support from colleagues is essential for any interviewer, no matter how experienced the researcher is. PMID: 24460560 [PubMed - in process] (Source: Nurse Researcher)

The Behind the Headlines 2013's Top Five of Top Fives

NHS News Feed — Tue, 31 Dec 2013 12:30:00 +0100

As we move towards the end of the year, like all news sources, we fall back on that classic space filler – the list story. So without further ado, here is the official Behind the Headlines Top Five of Top Fives stories of 2013. The top five "Good work team!" stories of the year We can often get bogged down in pointing out dodgy sub-group analyses, spurious extrapolations of samples sizes containing just four men and a dog, and RCTs pointing out the benefits of chocolate on blood pressure that turned out to be funded by a chocolate-making conglomerate. So it's important not to lose sight of the fact that there are many hardworking researchers, producing invaluable work, framed in the best traditions of evidence-based medicine, that does make the world a better place. Here’s...

Penile Sparing Surgery in Penile Cancer: Does It Affect Survival?

The Journal of Urology — Thu, 26 Dec 2013 00:00:00 +0100

(Source: The Journal of Urology)

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Comprehensive control of human papillomavirus infections and related diseases.

Vaccine — Sun, 22 Dec 2013 10:15:05 +0100

This article summarizes information from the chapters presented in a special ICO Monograph 'Comprehensive Control of HPV Infections and Related Diseases' Vaccine Volume 30, Supplement 5, 2012. Additional details on each subtopic and full information regarding the supporting literature references may be found in the original chapters. PMID: 24332295 [PubMed - in process] (Source: Vaccine)

The burden of human papillomavirus infections and related diseases in sub-saharan Africa.

Vaccine — Sun, 22 Dec 2013 10:15:05 +0100

This article forms part of a regional report entitled "Comprehensive Control of HPV Infections and Related Diseases in the Sub-Saharan Africa Region" Vaccine Volume 31, Supplement 5, 2013. Updates of the progress in the field are presented in a separate monograph entitled "Comprehensive Control of HPV Infections and Related Diseases" Vaccine Volume 30, Supplement 5, 2012. PMID: 24331746 [PubMed - in process] (Source: Vaccine)

Comprehensive control of human papillomavirus infections and related diseases.

Vaccine — Sun, 22 Dec 2013 10:15:05 +0100

Male circumcision 'doesn’t affect sexual satisfaction'

NHS News Feed — Thu, 12 Dec 2013 11:00:00 +0100

Conclusion This review combines the results of 36 studies reporting differences in sexual performance and satisfaction between circumcised and uncircumcised men. Most were observational studies, though two large RCTs from Kenya and Uganda were identified. The findings of the studies are discussed, and the review finds no evidence for any overall differences between circumcised and uncircumcised men in terms of sexual function or sexual pleasure. The review gathers together a large body of evidence, though the included studies will vary in their populations and methods of assessment. There are some factors that may be influencing the findings. For example, many studies were surveys, and recruitment for them is not described. It could be the case that men who have a satisfying sex life may ...

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Male circumcision 'doesn't affect sexual satisfaction'

NHS News Feed — Thu, 12 Dec 2013 11:00:00 +0100

Prognostic risk stratification derived from individual patient level data for men with advanced penile squamous cell carcinoma receiving first-line systemic therapy.

Urologic Oncology — Wed, 11 Dec 2013 05:00:00 +0100

CONCLUSIONS: In men with advanced PSCC receiving first-line systemic therapy, visceral metastases and ECOG PS≥1 were poor prognostic factors. A prognostic model including these factors exhibited moderate discriminatory ability for outcomes and warrants external validation. Patients receiving cisplatin-based regimens exhibited better outcomes compared with noncisplatin-based regimens after adjusting for prognostic factors. PMID: 24332646 [PubMed - as supplied by publisher] (Source: Urologic Oncology)

Four Ways Katie Couric Stacked The Deck Against Gardasil

Forbes.com Healthcare News — Thu, 05 Dec 2013 12:47:09 +0100

This afternoon, Katie Couric ran a long segment on her daytime talk show, Katie, about what she called the ?controversy? over the vaccines against human papilloma virus, or HPV, an infection that causes cervical, throat, penile, and anal cancers. She featured one mother who says that Gardasil, the HPV vaccine (Source: Forbes.com Healthcare News)

Re: Pathological Response to Neoadjuvant Chemotherapy for Muscle-Invasive Micropapillary Bladder Cancer

The Journal of Urology — Wed, 04 Dec 2013 00:00:00 +0100

J. J. Meeks, J. M. Taylor, K. Matsushita, H. W. Herr, S. M. Donat, B. H. Bochner and G. Dalbagni Department of Surgery, Urology Service, Memorial Sloan-Kettering Cancer Center, New York, New York (Source: The Journal of Urology)

Re: Novel Tumor Subgroups of Urothelial Carcinoma of the Bladder Defined by Integrated Genomic Analysis

The Journal of Urology — Wed, 04 Dec 2013 00:00:00 +0100

C. D. Hurst, F. M. Platt, C. F. Taylor and M. A. Knowles Cancer Research UK Centre, Leeds Institute of Molecular Medicine, St. James’s University Hospital, Leeds, United Kingdom (Source: The Journal of Urology)

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Penile Cancer: the importance of Prevention

International Braz J Urol — Tue, 03 Dec 2013 21:32:05 +0100

(Source: International Braz J Urol)

Male contraceptive pill 'a step closer'

Guardian Unlimited Science — Mon, 02 Dec 2013 21:19:34 +0100

Researchers announce discovery of proteins that can be blocked to prevent the launch of sperm cells during ejaculationA pill that provides a safe, effective and reversible method of contraception for men has been brought a step closer by scientists.Researchers identified two proteins that can be blocked to prevent the launch of sperm cells from the testes during ejaculation. Knocking out the proteins in genetically engineered mice resulted in male animals that were completely infertile, though they continued to mate normally. A similar goal could theoretically be achieved by suppressing the proteins with drugs, scientists say. In fact, medicines for prostate enlargement and high blood pressure already exist that blocks one of them."This concept is indeed a feasible mechanism of producing m...

Re: Intravesical Bacille Calmette-Guérin (BCG) in Immunologically Compromised Patients with Bladder Cancer

The Journal of Urology — Mon, 02 Dec 2013 00:00:00 +0100

H. W. Herr and G. Dalbagni Department of Urology, Memorial Sloan-Kettering Cancer Center, New York, New York (Source: The Journal of Urology)

Editorial Comment

The Journal of Urology — Mon, 02 Dec 2013 00:00:00 +0100

These authors expand the clinical usefulness of EPIC-CP by evaluating its responsiveness to HRQOL changes and defining MIDs for an erectile function prediction model after PCa surgery. The topic is important and the authors address a clinically relevant question. How do we translate questionnaires originally designed for research to the busy clinical setting? In contrast to the frequently used International Prostate Symptom Score and SHIM, EPIC-CP addresses quality of life as well as urinary and sexual function in a single 16-item questionnaire. More importantly, EPIC-CP demonstrated clinical feasibility in a study of more than 300 patients with prostate cancer with a time to completion of less than 5 minutes in most of them (reference 7 in article). Ultimately, EPIC-CP will need to suppl...

Re: Two Major Pathways of Penile Carcinogenesis: HPV-Induced Penile Cancers Overexpress p16ink4a, HPV-Negative Cancers Associated with Dermatoses Express p53, but Lack p16ink4a Overexpression

The Journal of Urology — Mon, 02 Dec 2013 00:00:00 +0100

S. Mannweiler, S. Sygulla, E. Winter and S. Regauer Institute of Pathology, Medical University Graz, Graz, Austria (Source: The Journal of Urology)

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Penile intraepithelial neoplasia with pagetoid features: report of an unusual variant mimicking Paget disease

Human Pathology — Mon, 02 Dec 2013 00:00:00 +0100

We describe the necessary steps to reach the final diagnose, including the use of immunohistochemistry for cytokeratin (CK) 7, CK20, CK34βE12, CAM 5.2, AE1/AE3, CEA, S100, Melan-A, and p63. We also discuss other differential diagnoses that should be considered such as malignant melanoma and urothelial carcinoma in situ with pagetoid spread and less common lesions such as pagetoid dyskeratosis, clear cell papulosis, and mucinous metaplasia. (Source: Human Pathology)

HPV vaccine could be offered to boys

NHS News Feed — Fri, 29 Nov 2013 12:00:00 +0100

"HPV vaccine could be given to boys as well as girls in UK," The Guardian reports. It goes on to say that, "Government advisers are to consider whether the HPV vaccine, routinely offered to girls at the ages of 12 and 13 since 2008 to help protect them against cervical cancer, should also be offered to boys and some men". The news appears to be based on draft minutes from the Joint Committee on Vaccination and Immunisation (JCVI). The JCVI advises the government on how vaccinations may reduce health problems – and considers the evidence on factors such as the prevalence of diseases, and the safety and effectiveness of vaccines. The latest draft minutes of the JCVI say that as part of its work on the HPV vaccine it agreed that "further work was required to cons...

Immunohistochemical Expression of the Mammalian Target of Rapamycin Pathway in Penile Squamous Cell Carcinomas: A Tissue Microarray Study of 112 Cases

Histopathology — Thu, 28 Nov 2013 04:15:25 +0100

ConclusionsOur results provide evidence of dysregulation of the mTOR pathway in penile carcinomas independent of HPV infection. Future clinical studies should further evaluate the prognostic and predictive usefulness of these markers in patients with penile cancer.This article is protected by copyright. All rights reserved. (Source: Histopathology)

Comprehensive control of human papillomavirus infections and related diseases.

Vaccine — Fri, 22 Nov 2013 05:00:00 +0100

Giant condyloma acuminatum; Buschke‐Loewenstein Tumor

Surgical Practice — Wed, 20 Nov 2013 05:00:00 +0100

Abstract Giant condyloma acuminatum, originally described by Buschke and Loewenstein (BLT) in 1925 as a lesion of the penis, is more rarely seen in the anorectum and is characterized by clinical malignancy in the face of histologic benignity; however, malignant transformation in about one third of patients to frankly invasive squamous‐cell carcinoma has been described. Malignant transformation has been reported in patients with "ordinary" condylomata acuminata as well. Human papillomavirus (HPV), known to cause condylomata acuminata, is also known to induce these tumors and found in 96% of 63 case reviewed in the last 10 years. Radical R0 excision independent of used surgical methods, along with vigilant follow‐up, provides the hope for cure. Conservative and or multimodal therapy is d...

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The Relationship between Characteristics of Inguinal Lymph Nodes and Pelvic Lymph Node Involvement in Penile Squamous Cell Carcinoma: A Single Institution Experience

The Journal of Urology — Tue, 19 Nov 2013 00:00:00 +0100

(Source: The Journal of Urology)

Implications for human papillomavirus in penile cancer

Urologic Oncology: Seminars and Original Investigations — Mon, 18 Nov 2013 05:00:00 +0100

Abstract: Human papillomavirus infection (HPV) has been implicated in penile cancer, and although the annual incidence is estimated to be 1,570 in the United States, there are areas of the world in which the incidence is as much as 20-fold higher. Ample data in the literature support testing and vaccination against HPV-related cervical cancer, but for men and penile cancer, these data are lacking. However, some preliminary data would suggest that HPV not only plays an important role in a significant subset of patients with penile cancer but also may be a target for penile cancer prevention as well via initiation of a vaccination program in high-risk male populations. (Source: Urologic Oncology: Seminars and Original Investigations)

A Clinical Trial Strategy for Penis Cancer

BJU International — Wed, 13 Nov 2013 05:00:00 +0100

(Source: BJU International)

Implications for human papillomavirus in penile cancer.

Urologic Oncology — Wed, 13 Nov 2013 05:00:00 +0100

Authors: Flaherty A, Kim T, Giuliano A, Magliocco A, Hakky TS, Pagliaro LC, Spiess PE Abstract Human papillomavirus infection (HPV) has been implicated in penile cancer, and although the annual incidence is estimated to be 1,570 in the United States, there are areas of the world in which the incidence is as much as 20-fold higher. Ample data in the literature support testing and vaccination against HPV-related cervical cancer, but for men and penile cancer, these data are lacking. However, some preliminary data would suggest that HPV not only plays an important role in a significant subset of patients with penile cancer but also may be a target for penile cancer prevention as well via initiation of a vaccination program in high-risk male populations. PMID: 24239463 [PubMed - as...

Epidermal Growth Factor Receptor-targeted Therapy in Squamous Cell Carcinoma of the Penis: A Report of 3 Cases

Urology — Wed, 13 Nov 2013 05:00:00 +0100

Conclusion: We report 3 cases in which EGFR-targeted therapy was used to treat platinum-refractory penile cancer patients. Because 2 of the 3 had clinical benefit, future prospective trials of EGFR-targeted therapy in penile cancer are warranted. (Source: Urology)

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Editorial Comment

Urology — Wed, 13 Nov 2013 05:00:00 +0100

Epidermal growth factor receptor (EGFR) is expressed in nonsmall cell lung cancer, head and neck squamous cell carcinoma, colorectal cancer, and breast cancer. In each of these diseases, there are EGFR inhibitors that are approved for these conditions. EGFR is expressed in squamous cell penile cancer. The question: is it potentially useful in patients with squamous cell penile cancer? There are important parameters whether a target for treatment is important or not. Is the target over expressed, could it be inhibited, is it the predominant target, is it an important factor for growth for this cancer, and could it be given safely. There are more questions than answers. Gou et al in a study of 150 patients in China with penile cancer showed EGFR expression was positive in all the 150 cases. ...

Reply

Urology — Wed, 13 Nov 2013 05:00:00 +0100

As the editorial comment points out, the gap between our knowledge of which markers are expressed on tumor cells and which of these markers will provide a successful therapeutic target has become increasingly apparent. Furthermore, the complexities of signaling pathways have complicated attempts to target receptors identified on tumor tissue: for example, K-ras mutations affect response to epidermal growth factor receptor (EGFR)–targeted therapy. In penile cancer, with nearly ubiquitous EGFR expression and low incidence of K-ras mutation, we might expect some response to EGFR-targeted therapy but will need to interrogate the pathway more comprehensively to understand why some patients benefit and others do not. In addition to biologic questions, there are important, if somewhat mundane c...

Human papillomavirus vaccination in adolescence

The Journal of the Royal Society for the Promotion of Health — Fri, 08 Nov 2013 05:00:00 +0100

This article explores the health benefits of the HPV vaccine, the impact of attitudes, cost-effectiveness and the involvement of school nurses in programme delivery. (Source: The Journal of the Royal Society for the Promotion of Health)

Oncological outcomes in patients who underwent glansectomy and skin grafting for treatment of penile squamous cell carcinoma

International Journal of Surgery — Wed, 06 Nov 2013 03:18:39 +0100

Introduction: Penile carcinoma is rare and the majority of disease is seen as squamous cell carcinoma (SCC). 80% of disease is distally located and is often amenable to penile preserving surgery. Glansectomy with split skin grafting is a widely used procedure, however, only a small number of centers have published data. (Source: International Journal of Surgery)

Cowden Syndrome and the PTEN Hamartoma Tumor Syndrome: Systematic Review and Revised Diagnostic Criteria

JNCI — Tue, 05 Nov 2013 05:00:00 +0100

Conclusions We propose revised, evidence-based criteria covering the spectrum of PTEN-related clinical disorders. Additional research on clinical features associated with PTEN mutations is warranted. (Source: JNCI)

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Potency preservation following stereotactic body radiation therapy for prostate cancer

Radiation Oncology — Fri, 01 Nov 2013 04:00:00 +0100

Conclusions: Men undergoing SBRT monotherapy for prostate cancer report sexual outcomes comparable to those reported for conventional radiation modalities within the first 24 months after treatment. Longer follow-up is required to confirm the durability of these findings. (Source: Radiation Oncology)

Re: Role of Marker Lesion When Applying Intravesical Instillations of IL-2 for Non-Muscle-Invasive Bladder Cancer Comparison of the Therapeutic Effects in Two Pilot Studies

The Journal of Urology — Thu, 31 Oct 2013 04:00:00 +0100

W. Den Otter, R. J. Van Moorselaar, J. J. Jacobs, R. T. Haar, J. W. Koten, Z. Dobrowolski, W. Lipczynski, V. Pašukonienė, D. Characiejus, F. Jankevičius, R. Eidukevičius and T. M. De Reijke (Source: The Journal of Urology)

Re: Comparative Outcomes of Primary, Recurrent, and Progressive High-Risk Non-Muscle-Invasive Bladder Cancer

The Journal of Urology — Thu, 31 Oct 2013 04:00:00 +0100

F. Thomas, A. P. Noon, N. Rubin, J. R. Goepel and J. W. Catto Academic Urology Unit, University of Sheffield, Sheffield, United Kingdom (Source: The Journal of Urology)

Re: Final Results of an EORTC-GU Cancers Group Randomized Study of Maintenance Bacillus Calmette-Guérin in Intermediate- and High-Risk Ta, T1 Papillary Carcinoma of the Urinary Bladder: One-Third Dose versus Full Dose and 1 Year versus 3 Years of Maintenance

The Journal of Urology — Wed, 30 Oct 2013 04:00:00 +0100

J. Oddens, M. Brausi, R. Sylvester, A. Bono, C. van de Beek, G. van Andel, P. Gontero, W. Hoeltl, L. Turkeri, S. Marreaud, S. Collette and W. Oosterlinck Department of Urology, Jeroen Bosch Ziekenhuis, 's-Hertogenbosch, The Netherlands (Source: The Journal of Urology)

Re: A Prospective Analysis of Penile Length Changes Following Radical Prostatectomy

The Journal of Urology — Wed, 30 Oct 2013 04:00:00 +0100

B. M. Berookhim, C. J. Nelson, B. Kunzel, J. P. Mulhall and J. B. Narus Male Sexual and Reproductive Medicine Program, Urology Service, Memorial Sloan-Kettering Cancer Center, New York, New York (Source: The Journal of Urology)

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Re: Diphtheria Toxin-Epidermal Growth Factor Fusion Protein DAB389EGF for the Treatment of Bladder Cancer

The Journal of Urology — Wed, 30 Oct 2013 04:00:00 +0100

X. Yang, E. Kessler, L. J. Su, A. Thorburn, A. E. Frankel, Y. Li, F. G. La Rosa, J. Shen, C. Y. Li, M. Varella-Garcia, L. M. Glodé and T. W. Flaig Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado (Source: The Journal of Urology)

Phase II trial of docetaxel, cisplatin and 5FU chemotherapy in locally advanced and metastatic penis cancer (CRUK/09/001)

British Journal of Cancer AOP — Tue, 29 Oct 2013 04:00:00 +0100

Phase II trial of docetaxel, cisplatin and 5FU chemotherapy in locally advanced and metastatic penis cancer (CRUK/09/001) British Journal of Cancer advance online publication, October 29 2013. doi:10.1038/bjc.2013.620 Authors: S Nicholson, E Hall, S J Harland, J D Chester, L Pickering, J Barber, T Elliott, A Thomson, S Burnett, C Cruickshank, B Carrington, R Waters & A Bahl (Source: British Journal of Cancer AOP)

Diversity of HPV types in cancerous and pre‐cancerous penile lesions of South African men: Implications for future HPV vaccination strategies

Journal of Medical Virology — Fri, 25 Oct 2013 06:15:10 +0100

This study reports the detection of HPV types from cancerous and pre‐cancerous penile lesions that were diagnosed histologically. Sixty‐six (22 pre‐cancerous and 44 cancerous lesions) tissue biopsies, received between 2004 and 2011 by the Anatomical Pathology Department at Dr. George Mukhari Hospital were selected for this study. Total DNA was extracted and genotyped using type specific real‐time quantitative polymerase chain reaction (qPCR) for 18 HPV types. Of 66 samples, only 51 were included in the analysis. Overall, HPV 11 (50.9%) and HPV 16 (49.1%) showed almost similar incidence in the study patients. In pre‐cancerous lesions, HPV 11 was more frequent (80.0%), followed by HPV 31 and HPV 16 at 25.0% each and other HPV types included 35 (15.0%), 59 (15.0%), 53 (10.0%), 33 (1...

Impact of medical education on knowledge and attitudes regarding the human papilloma virus and vaccination: Comparison before and 6 years after the introduction of the vaccines.

Vaccine — Wed, 23 Oct 2013 04:00:00 +0100

CONCLUSION: The facts that vaccination programs are regarded as being important, and that knowledge on HPV increased, do not automatically result in an increase in participation in HPV vaccination programs. To increase participation, information must be provided with arguments that cannot be misinterpreted. PMID: 24161571 [PubMed - as supplied by publisher] (Source: Vaccine)

Elevated C-reactive protein values predict nodal metastasis in patients with penile cancer

BMC Urology - Latest articles — Tue, 22 Oct 2013 04:00:00 +0100

Conclusions: Since a high preoperative serum CRP level was closely correlated with nodal disease, it could be used as an additional marker to help identify patients with penile cancer who may benefit from inguinal lymph node dissection. (Source: BMC Urology - Latest articles)

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Warty carcinoma of the penis: A clinicopathological study from South India

Indian Journal of Urology — Mon, 21 Oct 2013 04:00:00 +0100

Conclusion: Warty carcinoma constitutes nearly 10% of all penile squamous cell cancers. These patients seem to have a less aggressive behavior than SC-NOS. (Source: Indian Journal of Urology)

Human papillomaviruses in urological malignancies: A critical assessment

Urologic Oncology: Seminars and Original Investigations — Mon, 21 Oct 2013 04:00:00 +0100

Conclusions: An increasing number of immunocompromised patients as well as novel developments in patient care may change the spectrum of HPV-associated neoplasms. This is examplified by results demonstrating a role of HPVs in rare urothelial carcinomas with squamous differentiation in patients with neurogenic bladder. Hence, it is important to keep HPV infection in mind when confronted with unusual disease manifestations of the urogenital tract. (Source: Urologic Oncology: Seminars and Original Investigations)

Blood Type, Lymphadenectomy and Blood Transfusion Predict Venous Thromboembolic Events Following Radical Prostatectomy with Pelvic Lymphadenectomy

The Journal of Urology — Fri, 18 Oct 2013 00:00:00 +0100

Purpose: Venous thromboembolic events are the most common nonoperative complication after radical prostatectomy and they represent the most common cause of death within 30 days of surgery. While effective mechanical and chemoprophylaxis exists, such prophylaxis may also be associated with increased complications. To identify venous thromboembolic event risk factors and, thereby, facilitate targeted prophylaxis we characterized clinicopathological variables associated with these events in patients undergoing radical prostatectomy.Materials and Methods: We reviewed the records of 18,472 consecutive patients who underwent radical prostatectomy with pelvic lymphadenectomy for prostate cancer at our institution from 1987 to 2010. Patients were followed postoperatively for complications. Venous ...

Human papillomaviruses in urological malignancies: A critical assessment.

Urologic Oncology — Thu, 17 Oct 2013 04:00:00 +0100

CONCLUSIONS: An increasing number of immunocompromised patients as well as novel developments in patient care may change the spectrum of HPV-associated neoplasms. This is examplified by results demonstrating a role of HPVs in rare urothelial carcinomas with squamous differentiation in patients with neurogenic bladder. Hence, it is important to keep HPV infection in mind when confronted with unusual disease manifestations of the urogenital tract. PMID: 24140249 [PubMed - as supplied by publisher] (Source: Urologic Oncology)

[Neoadjuvant, adjuvant and palliative chemotherapy of penile cancer.]

Der Urologe. Ausg. A — Wed, 16 Oct 2013 04:00:00 +0100

Authors: Protzel C, Seitz AK, Hakenberg OW, Retz M Abstract Data on the treatment of advanced penile carcinoma especially for chemotherapy are very limited. Due to the results of recent studies there has been a shift to taxan/cisplatinum based regimens. Initial case reports also showed a response to targeted therapy especially antibodies against epidermal growth factor receptor (EGFR). Nevertheless, a curative treatment by medicinal approaches alone does not appear to be possible for metastatic penile cancer and can be only cured by multimodal approaches, including neoadjuvant and adjuvant chemotherapy and salvage lymph node dissection. Palliative chemotherapy of advanced penile cancer has to be individually adapted and weighed against best supportive care for the final decision. ...

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Immunohistochemical profile of the penile urethra and differential expression of GATA3 in urothelial versus squamous cell carcinomas of the penile urethra

Human Pathology — Wed, 16 Oct 2013 04:00:00 +0100

In conclusion, the penile urethra is covered by epithelial cells that are unique in morphology and immunohistochemical profile. In addition, our study suggests that GATA3 and human papillomavirus detection are useful markers for distinguishing urothelial carcinomas from squamous cell carcinomas of the penile urethra. (Source: Human Pathology)

Penile metastasis from primary cholangiocarcinoma: the first case report

BMC Gastroenterology — Mon, 14 Oct 2013 04:00:00 +0100

Conclusions: To date, there is no case of penile or urogenital system metastasis from CCA described in the literature. Therefore, this article represents the first case report of penile metastasis from CCA. (Source: BMC Gastroenterology)

Stage Presentation, Care Patterns, and Treatment Outcomes for Squamous Cell Carcinoma of the Penis

International Journal of Radiation Oncology * Biology * Physics — Thu, 10 Oct 2013 04:00:00 +0100

Conclusion: SCC of the penis often presents as early-stage T1, N0, M0, grade 1, or grade 2 disease. The majority of patients identified were treated with surgery, and only a small fraction of patients received radiation therapy alone or as adjuvant therapy. (Source: International Journal of Radiation Oncology * Biology * Physics)

Re: Gender-Dependent Cancer-Specific Survival Following Radical Cystectomy

The Journal of Urology — Mon, 07 Oct 2013 04:00:00 +0100

M. May, C. Stief, S. Brookman-May, W. Otto, C. Gilfrich, J. Roigas, M. Zacharias, W. F. Wieland, H. M. Fritsche, F. Hofstädter and M. Burger Department of Urology, St. Elisabeth Hospital, Straubing, Germany (Source: The Journal of Urology)

Re: Lymph Node Density for Patient Counselling about Prognosis and for Designing Clinical Trials of Adjuvant Therapies after Radical Cystectomy

The Journal of Urology — Mon, 07 Oct 2013 04:00:00 +0100

E. K. Lee, H. W. Herr, R. J. Dickstein, W. Kassouf, M. F. Munsell, H. B. Grossman, C. P. Dinney and A. M. Kamat Departments of Urology and Biostatistics, University of Texas M.D. Anderson Cancer Center, Houston, Texas (Source: The Journal of Urology)

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Re: Anatomic Basis for Lymph Node Counts as Measure of Lymph Node Dissection Extent: A Cadaveric Study

The Journal of Urology — Mon, 07 Oct 2013 04:00:00 +0100

J. D. Davies, C. M. Simons, N. Ruhotina, D. A. Barocas, P. E. Clark and T. M. Morgan Department of Urologic Surgery, Vanderbilt University Medical Center, Nashville, Tennessee (Source: The Journal of Urology)

Human Papilloma Virus: Prevalence, distribution and predictive value to lymphatic metastasis in penile carcinoma

International Braz J Urol — Sat, 05 Oct 2013 17:24:12 +0100

Objectives To evaluate the prevalence, distribution and association of HPV with histological pattern of worse prognosis of penile cancer, in order to evaluate its predictive value of inguinal metastasis, as well as evaluation of other previous reported prognostic factors. Material and Methods Tumor samples of 82 patients with penile carcinoma were tested in order to establish the prevalence and distribution of genotypic HPV using PCR. HPV status was correlated to histopathological factors and the presence of inguinal mestastasis. The influence of several histological characteristics was also correlated to inguinal disease-free survival. Results Follow-up varied from 1 to 71 months (median 22 months). HPV DNA was identified in 60.9% of sample, wi...

Extending boundaries in minimally invasive procedures with simultaneous bilateral video endoscopic inguinal lymphadenectomy (veil) for penile cancer: initial Denver health medical center and ABC school of medicine experience and surgical considerations

International Braz J Urol — Sat, 05 Oct 2013 17:24:12 +0100

Conclusion: Simultaneous lymphadenectomy procedures are feasible. Improvement in operative and anesthesia time could decrease the morbidity associated with inguinal lymphadenectomy while maintaining the oncological principles. (Source: International Braz J Urol)

Partial Penectomy and Penile Reconstruction. Initial Surgical Management of Localized Penile Cancer.

Actas Urologicas Espanolas — Sat, 05 Oct 2013 04:00:00 +0100

CONCLUSIONS: Given the results presented hereby we propose that PR must be part of the same procedure as the PP. PMID: 24103396 [PubMed - as supplied by publisher] (Source: Actas Urologicas Espanolas)

HPV‐Related Cancers After Solid Organ Transplantation in the United States

American Journal of Transplantation — Tue, 01 Oct 2013 04:00:00 +0100

We examined the incidence of HPV‐related cancers in 187 649 US recipients in the Transplant Cancer Match Study. Standardized incidence ratios (SIRs) compared incidence rates to the general population, and incidence rate ratios (IRRs) compared rates across transplant subgroups. We observed elevated incidence of HPV‐related cancers (SIRs: in situ 3.3–20.3, invasive 2.2–7.3), except for invasive cervical cancer (SIR 1.0). Incidence increased with time since transplant for vulvar, anal and penile cancers (IRRs 2.1–4.6 for 5+ vs. <2 years). Immunophenotype, characterized by decreased incidence with HLA DRB1:13 and increased incidence with B:44, contributed to susceptibility at several sites. Use of specific immunosuppressive medications was variably associated with incidence; for...

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Pathology of tumours of the male genital tract

Surgery (Medicine Publishing) — Tue, 01 Oct 2013 01:17:14 +0100

Abstract: Tumours of the male genital tract are diverse. Prostatic adenocarcinoma is important because of its high incidence and mortality, the increased frequency of detection following a drive towards early diagnosis and the need to identify those early cancers requiring immediate intervention and those suitable for an active surveillance programme. Testicular germ cell tumours are relatively uncommon but are important because they involve a young patient group and, although potentially highly aggressive, have been a remarkable success story of modern chemotherapy with current cure rates of approximately 97–98%. Penile cancer largely overlaps with the more common cutaneous cancer types. (Source: Surgery (Medicine Publishing))

The epidermal growth factor receptor is frequently overexpressed in penile squamous cell carcinomas: a tissue microarray and digital image analysis study of 112 cases

Human Pathology — Fri, 27 Sep 2013 04:00:00 +0100

In conclusion, immunohistochemical EGFR expression appears to be a common feature of penile carcinomas, independently of histologic subtype, histologic grade, and human papillomavirus presence. Whether or not EGFR expression is associated with EGFR gene mutation or if it can be used to predict response to therapy in patients with disseminated penile cancer should be evaluated in future studies. (Source: Human Pathology)

Measuring and Predicting Prostate Cancer Related Quality of Life Changes Using EPIC for Clinical Practice

The Journal of Urology — Thu, 26 Sep 2013 00:00:00 +0100

Conclusions: EPIC-CP is responsive to health related quality of life changes during convalescence and it can be used to predict 2-year post-prostatectomy sexual outcomes. It can facilitate shared medical decision making and patient centered care. (Source: The Journal of Urology)

Population Based Study of Predictors of Adverse Pathology among Candidates for Active Surveillance with Gleason 6 Prostate Cancer

The Journal of Urology — Wed, 25 Sep 2013 04:00:00 +0100

Conclusions: More than a third of men meeting the most stringent active surveillance criteria had adverse pathology at radical prostatectomy in this population based cohort. Active surveillance programs should consider prostate specific antigen density and extent of cancer on biopsy for patient selection. (Source: The Journal of Urology)

Prostate Specific Antigen Velocity Risk Count Predicts Biopsy Reclassification for Men with Very Low Risk Prostate Cancer

The Journal of Urology — Mon, 23 Sep 2013 00:00:00 +0100

Conclusions: Prostate specific antigen velocity risk count may be useful for monitoring patients on active surveillance and decreasing the frequency of biopsies needed in the long term. (Source: The Journal of Urology)

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Chromosomal gains and losses in human papillomavirus-associated neoplasia of the lower genital tract – A systematic review and meta-analysis

European Journal of Cancer — Thu, 19 Sep 2013 04:00:00 +0100

Abstract: Background: Overexpression of the human papillomavirus (HPV) oncogenes E6 and E7 is necessary for the development of distinct lower genital tract cancers. However, secondary cellular genomic alterations are mandatory to promote progression of HPV-induced premalignant stages. We aimed at identifying the chromosomal regions most frequently gained and lost and the disease stage at which the latter occurs. These regions might be relevant for carcinogenesis and could serve as diagnostic markers to identify premalignant lesions with high progression risk towards invasive cancer.Methods: We performed a systematic literature review and meta-analysis of studies listed in PubMed that analysed chromosomal copy number alterations by comparative genomic hybridisation (CGH) in HPV-positive and...

Editorial Comment

The Journal of Urology — Wed, 18 Sep 2013 04:00:00 +0100

The ultimate goal of AS is to reduce unnecessary treatment in patients with low risk prostate cancer. However, the lack of an effect on pathological progression calls into question the validity of using dutasteride in this population. This analysis also showed that older age and higher PSA density were predictors of pathological progression. PSA density has been consistently shown to be associated with progression (reference 12 in article), and should be used for patient counseling before commencing AS. The finding that age was associated with progression also supports the current practice patterns, where no minimum age is required to be included in AS protocols. Younger patients have a longer life expectancy but are also less likely to have progression. Another interesting finding is the ...

Reply by Authors

The Journal of Urology — Wed, 18 Sep 2013 04:00:00 +0100

Although there is no standardized approach for the followup of patients with low risk, localized prostate cancer undergoing active surveillance, protocols usually include frequent PSA measurements, DRE and biopsies. We agree with Adamy and Kotb that in the absence of improved markers of disease progression, regular biopsies are an important part of followup for these patients. Indeed, pathological progression was detected by scheduled biopsy in 93% of patients in this subset of the REDEEM study. (Source: The Journal of Urology)

Comparison of robot-assisted and laparoscopic pelvic lymphadenectomy in penile cancer patients with stage N2/N3 inguinal disease

International Journal of Surgery — Tue, 17 Sep 2013 13:17:42 +0100

Introduction: Favourable outcomes using robot assisted pelvic lymphadenectomy (RAPL) have been demonstrated in patients with bladder and prostate cancer. Current EAU guidelines recommend ipsilateral pelvic lymphadenectomy for penile cancer patients with metastatic inguinal lymph nodes found at radical inguinal lymphadenectomy. We have compared experience of RAPL and laparoscopic pelvic lymphadenectomy (LPL) for penile cancer patients with N2/N3 disease in a single centre. (Source: International Journal of Surgery)

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Reply by Authors

The Journal of Urology — Tue, 17 Sep 2013 04:00:00 +0100

This study demonstrates the advantage of fusion technology in improving the cancer detection rate in a group of men in whom systematic 12-core TRUS guided biopsy often fails. We acknowledge that only patients with MR visible lesions underwent MR-US fusion biopsy, which could potentially cause bias. However, small lesions below the threshold of MR imaging most likely do not represent clinically significant prostate cancer (reference 29 in article). As mentioned, studies such as that of Matsuoka et al (reference 3 in comment), analysis from the fusion database reported by Kuru et al (reference 2 in comment) and others are essential to validate these results. (Source: The Journal of Urology)

Editorial Comment

The Journal of Urology — Tue, 17 Sep 2013 04:00:00 +0100

These authors explored the significance of prostate cancer invasion into the prostate capsule without EPE, ie a subset of patients with pT2N0 prostate cancer, defined as OC PCI positive. They compared PSA recurrence rates in such cases to those without any invasion into the prostate capsule, defined as OC PCI negative. The motivation of the study was that a difference between groups might identify a subset of patients who could benefit from adjuvant therapy and studies to date of this subject have been sparse and conflicting. Such a study is extremely challenging because, as the authors point out, the prostate capsule is a poorly defined structure, which makes it difficult to determine the degree of invasion in any consistent manner, possibly masking any significance. Subsequently, they fo...

Leukemoid Reaction: A Rare Paraneoplastic Syndrome in Bladder Cancer Associated With a Grave Prognosis

Urology — Mon, 16 Sep 2013 04:00:00 +0100

A 43-year-old man presented with fevers to 101.8°F and malaise over a 2-week period. One month before presentation, he developed an episode of gross hematuria. Subsequent cystoscopy revealed a 5 cm bladder tumor. He underwent transurethral resection of the bladder tumor, and pathology showed muscle-invasive squamous cell carcinoma. His past medical history was significant for hemiplegia and frontal lobe syndrome secondary to a head injury, yet he did not have the typical risk factor of long-term indwelling catheter. He had no family history of genitourinary malignancy. He had a remote history of smoking as a teenager. He had no history of international travel or occupational chemical exposure. Further review of systems elicited a recent development of pus-like discharge from his penis. (S...

Squamous cell carcinoma of the penis and topical combination corticosteroid products: a cautionary case.

Dermatol Online J — Thu, 12 Sep 2013 03:40:03 +0100

We present a case of an invasive squamous cell carcinoma of the glans penis, which was treated with topical anti-fungals and corticosteroids for 2 years prior to diagnosis, necessitating partial glansectomy. PMID: 24010516 [PubMed - in process] (Source: Dermatol Online J)

[Seminar] Human papillomavirus and cervical cancer

LANCET — Sat, 07 Sep 2013 04:00:00 +0100

Cervical cancer is caused by human papillomavirus infection. Most human papillomavirus infection is harmless and clears spontaneously but persistent infection with high-risk human papillomavirus (especially type 16) can cause cancer of the cervix, vulva, vagina, anus, penis, and oropharynx. The virus exclusively infects epithelium and produces new viral particles only in fully mature epithelial cells. Human papillomavirus disrupts normal cell-cycle control, promoting uncontrolled cell division and the accumulation of genetic damage. (Source: LANCET)

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Epidermal Growth Factor Receptor–Targeted Therapy in Locally Advanced or Metastatic Squamous Cell Carcinoma of the Penis

BJU International — Thu, 05 Sep 2013 04:00:00 +0100

ConclusionOur results suggest that cetuximab has antitumor activity in metastatic penile cancer, and may enhance the effect of cisplatin‐based chemotherapy. Prospective studies of EGFR‐targeted therapies in men with these tumors are warranted. (Source: BJU International)

Should centralised histopathological review in penile cancer be the global standard?

BJU International — Thu, 05 Sep 2013 04:00:00 +0100

Conclusions● In this study a significant proportion of penile cancer histology reports were revised following review in the Sn‐MDT. Many of these changes altered patient management.● This provides evidence that accurate pathological diagnosis plays a crucial role in determining the correct treatment and maximising the potential for good clinical outcomes in penile cancer.● In the case of histopathology, centralisation has increased exposure to penile cancer and diagnostic accuracy, and should therefore be considered the gold standard. (Source: BJU International)

Re: Long-Term Results of Maintenance Treatment of Mitomycin C or Alternating Mitomycin C and Bacillus Calmette-Guérin Instillation Therapy of Patients with Carcinoma In Situ of the Bladder: A Subgroup Analysis of the Prospective Finnbladder 2 Study with a 17-Year Follow-up

The Journal of Urology — Tue, 03 Sep 2013 04:00:00 +0100

R. Järvinen, E. Kaasinen, E. Rintala and T. F. Group Department of Urology, Helsinki University Hospital, Helsinki, Finland (Source: The Journal of Urology)

Re: A Phase 2 Clinical Trial of Sequential Neoadjuvant Chemotherapy with Ifosfamide, Doxorubicin, and Gemcitabine Followed by Cisplatin, Gemcitabine, and Ifosfamide in Locally Advanced Urothelial Cancer: Final Results

The Journal of Urology — Tue, 03 Sep 2013 04:00:00 +0100

A. O. Siefker-Radtke, C. P. Dinney, Y. Shen, D. L. Williams, A. M. Kamat, H. B. Grossman and R. E. Millikan Department of Genitourinary Medical Oncology, University of Texas M. D. Anderson Cancer Center, Houston, Texas (Source: The Journal of Urology)

Clinical characteristics of patients with multiple potentially human papillomavirus–related malignancies

Head and Neck — Mon, 02 Sep 2013 04:00:00 +0100

ConclusionThese data suggest differential patterns for development of multiple HPV‐related cancers based upon clinical characteristics. Prospective longitudinal and population‐based studies are warranted to understand the impact of these findings and opportunities for intervention and screening. © 2013 Wiley Periodicals, Inc. Head Neck, 2013 (Source: Head and Neck)

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[Penile cancer - a challenge for modern uro-oncology].

Aktuelle Urologie — Sun, 01 Sep 2013 04:00:00 +0100

Authors: Protzel C, Hakenberg OW Abstract Due to the low incidence of penile cancer in Europe and North America and often decentralised patient management, data on the treatment of penile cancer are very rare. Nevertheless, recently relevant data have become available for the improvement of the therapy especially for the primary tumours. Penile conserving surgery is becoming more important for early tumour stages. The management of lymph nodes plays a key role for the successful treatment of patients with penile cancer. An invasive lymph node staging is recommended for all patients with primary pT1G2 or higher tumours. Neoadjuvant chemotherapy followed by salvage lymphadenectomy has shown promising results in patients with large and/or fixed inguinal lymph node metastases. Due to t...

Ultrasound Examination and Fine Needle Aspiration Cytology—Useful for Followup of the Regional Nodes in Penile Cancer?

The Journal of Urology — Thu, 29 Aug 2013 00:00:00 +0100

Conclusions: Although inguinal recurrence manifests clinically in most patients, ultrasound guided fine needle aspiration cytology detected 80% of metastatic disease in patients with nonpalpable disease. Therefore, it has great value for detecting lymph node metastases during followup. (Source: The Journal of Urology)

Perceptions of HPV, Genital Warts, and Penile/Anal Cancer and High-Risk Sexual Behaviors Among Men Who Have Sex with Men in Hong Kong.

Archives of Sexual Behavior — Wed, 28 Aug 2013 04:00:00 +0100

Authors: Lau JT, Wang Z, Lau M, Lai CH Abstract The prevalence of HIV and HPV is high among men who have sex with men (MSM) in China. It is unclear whether cognitive and affective responses related to HPV and HPV-related diseases are negatively associated with HIV-related risk behaviors among MSM. This cross-sectional study interviewed 449 adult Chinese MSM in Hong Kong. The prevalence of unprotected anal intercourse (UAI) and having had anal sex with more than one man in the last 6 months (multiple male sex partnerships) was 39.0 and 71.3 %, respectively. After adjusting for four significant background variables (education level, cohabitation with a man, exposure to HIV prevention materials, and HIV voluntary counseling and testing), variables negatively associated with UAI and/...

Genital pyoderma gangrenosum: Report of two cases and published work review of Japanese cases

The Journal of Dermatology — Wed, 21 Aug 2013 04:00:00 +0100

In conclusion, genital pyoderma gangrenosum is rare and may be misdiagnosed. It should therefore be considered in cases of refractory genital ulcers. In addition, genitalia‐localized pyoderma gangrenosum tends to be without systemic complications. (Source: The Journal of Dermatology)

[National second-opinion network for testicular cancer patients : Results of a user survey.]

Der Urologe. Ausg. A — Wed, 21 Aug 2013 04:00:00 +0100

Authors: Zengerling F, Schrader AJ, Mohr A, Schrader M Abstract BACKGROUND: The national second opinion project of the German Testicular Cancer Study Group (GTCSG) has served to improve the quality of care provided to testicular cancer patients since 2006. AIM: A recent online survey was carried out to characterize the users of the second opinion offer and clarify their motivation for participating in the project. Furthermore, the aim was to identify weaknesses of the project which could be improved. A total of 440 users of the second opinion project were contacted of whom 192 participated in the survey. RESULTS: In summary, the data collected showed a high degree of satisfaction among the participants who appreciated the second opinions received. Some issues with a need fo...

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Nightly vs on‐demand sildenafil for penile rehabilitation after minimally invasive nerve‐sparing radical prostatectomy: results of a randomized double‐blind trial with placebo

BJU International — Tue, 13 Aug 2013 04:00:00 +0100

Conclusions Erectile recovery up to 1 year after RP does not differ between previously potent men who use sildenafil nightly compared to on‐demand. This trial does not support chronic nightly sildenafil as being any better than on‐demand sildenafil for use in penile rehabilitation after nerve‐sparing minimally invasive RP. (Source: BJU International)

Lymphoepithelioma‐like carcinoma of the penis: association with human papilloma virus infection

Histopathology — Mon, 12 Aug 2013 04:00:00 +0100

Contemporary Management of Regional Nodes in Penile Cancer—Improvement of Survival?

The Journal of Urology — Mon, 05 Aug 2013 04:00:00 +0100

Conclusions: Despite less surgery being performed on regional nodes, 5-year cancer specific survival has improved in patients with cN0 disease. The number of tumor positive nodes, extranodal extension and pelvic involvement were highly associated with worse cancer specific survival in patients with pN+ disease. In this group other treatment strategies are needed as no improvement was observed. (Source: The Journal of Urology)

Editorial Comment

The Journal of Urology — Mon, 29 Jul 2013 04:00:00 +0100

In light of recent guidelines stating that the negative impacts of the current pathway outweigh the benefits, minimally invasive therapies that accurately target prostate cancer to preserve tissue and decrease harm may offer the solution needed. (Source: The Journal of Urology)

The impact of surgical treatment for penile cancer – Patients' perspectives

European Journal of Oncology Nursing — Mon, 29 Jul 2013 04:00:00 +0100

Conclusion: A key area for the development of care is to devise and evaluate procedures for ensuring that men are well-informed about the extent and potential consequences of their treatment. Men's experiences of penile cancer surgery will be informed by a complex web interlaced with their broader lives, making it difficult for health professionals to judge how surgery will impact on a men presenting to them. Further research is required to ascertain the most appropriate strategies for rehabilitation of men experiencing penile cancer surgery. (Source: European Journal of Oncology Nursing)

Re: Prospective Evaluation of MRI, 11C-Acetate PET/CT and Contrast-Enhanced CT for Staging of Bladder Cancer

The Journal of Urology — Mon, 29 Jul 2013 04:00:00 +0100

H. A. Vargas, O. Akin, H. Schöder, S. Olgac, G. Dalbagni, H. Hricak and B. H. Bochner Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, New York (Source: The Journal of Urology)

Re: Combination of Molecular Alterations and Smoking Intensity Predicts Bladder Cancer Outcome: A Report from the Los Angeles Cancer Surveillance Program

The Journal of Urology — Mon, 29 Jul 2013 04:00:00 +0100

A. P. Mitra, J. E. Castelao, D. Hawes, D. D. Tsao-Wei, X. Jiang, S. R. Shi, R. H. Datar, E. C. Skinner, J. P. Stein, S. Groshen, M. C. Yu, R. K. Ross, D. G. Skinner, V. K. Cortessis and R. J. Cote (Source: The Journal of Urology)

Re: Inhibition of Bladder Cancer by Broccoli Isothiocyanates Sulforaphane and Erucin: Characterization, Metabolism, and Interconversion

The Journal of Urology — Mon, 29 Jul 2013 04:00:00 +0100

B. Abbaoui, K. M. Riedl, R. A. Ralston, J. M. Thomas-Ahner, S. J. Schwartz, S. K. Clinton and A. Mortazavi Ohio State University, Columbus, Ohio (Source: The Journal of Urology)

The impact of surgical treatment for penile cancer - Patients' perspectives.

European Journal of Oncology Nursing — Fri, 26 Jul 2013 04:00:00 +0100

CONCLUSION: A key area for the development of care is to devise and evaluate procedures for ensuring that men are well-informed about the extent and potential consequences of their treatment. Men's experiences of penile cancer surgery will be informed by a complex web interlaced with their broader lives, making it difficult for health professionals to judge how surgery will impact on a men presenting to them. Further research is required to ascertain the most appropriate strategies for rehabilitation of men experiencing penile cancer surgery. PMID: 23896180 [PubMed - as supplied by publisher] (Source: European Journal of Oncology Nursing)

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Key role in HPV prevention played by vaccination of boys

Health News from Medical News Today — Thu, 25 Jul 2013 07:00:00 +0100

Improving vaccination rates against the human papillomavirus (HPV) in boys aged 11 to 21 is key to protecting both men and women, says new research from University of Toronto Professor Peter A. Newman from the Factor-Inwentash Faculty of Social Work. HPV has been linked to anal, penile and certain types of throat cancers in men. Since the virus is also responsible for various cancers in women, vaccinating boys will play a crucial role in reducing cancer rates across the sexes... (Source: Health News from Medical News Today)

Creation of RTOG compliant patient CT-atlases for automated atlas based contouring of local regional breast and high-risk prostate cancers

Radiation Oncology — Thu, 25 Jul 2013 04:00:00 +0100

Conclusions: A method to construct and validate performance of CT-based multi-patient atlases for automated atlas based auto-contouring has been demonstrated, and can be adopted for clinical use in planning of local regional breast and high-risk prostate radiotherapy. (Source: Radiation Oncology)

Erosion of Inflatable Penile Prosthesis Reservoir into Neobladder

The Journal of Sexual Medicine — Wed, 24 Jul 2013 04:00:00 +0100

ConclusionsIn patients with a history of abdomino‐pelvic surgery or radiation therapy, the retroperitoneal space may be extremely fibrotic and the transversalis fascia may have thickened. Potential intraoperative complications as well as reservoir erosion may be avoided by using a two‐piece device or ectopic reservoir placement. Management options for reservoir erosion include explantation of the entire device as well as reservoir removal with salvage of remaining components. Tran CN, Boncher N, Montague DK, and Angermeier KW. Erosion of inflatable penile prosthesis reservoir into neobladder. J Sex Med **;**:**–**. (Source: The Journal of Sexual Medicine)

High grade prostatic adenocarcinoma with a partly intraductal growth pattern producing a mimic of urothelial carcinoma in situ

Journal of Clinical Pathology — Mon, 22 Jul 2013 04:00:00 +0100

We present a series of three cases in which the high grade prostatic adenocarcinoma mimics urothelial carcinoma in situ, through a partly intraductal growth pattern within the prostatic duct system and partial replacement of the urothelium of the prostatic urethra. This may be a potential diagnostic pitfall, especially if present in small superficial mucosal biopsies, or when represented in samples from the bladder neck or penile urethra. Case 1 A 70-year-old male subject underwent radical prostatectomy with bilateral iliac lymph node dissection for prostatic adenocarcinoma, following diagnosis on needle core prostatic biopsies performed for an elevated serum prostate specific antigen (PSA) of... (Source: Journal of Clinical Pathology)

Vaccinating boys plays key role in HPV prevention

EurekAlert! - Social and Behavioral Science — Mon, 22 Jul 2013 04:00:00 +0100

(University of Toronto) Improving vaccination rates against the human papillomavirus (HPV) in boys is key to protecting both men and women, says new research from University of Toronto Professor Peter A. Newman from the Factor-Inwentash Faculty of Social Work. HPV has been linked to anal, penile and certain types of throat cancers in men. Since the virus is also responsible for various cancers in women, vaccinating boys aged 11 to 21 will play a crucial role in reducing cancer rates across the sexes. (Source: EurekAlert! - Social and Behavioral Science)

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Fascia Lata Preservation During Inguinal Lymphadenectomy for Penile Cancer: Rationale and Outcome

Urology — Mon, 22 Jul 2013 04:00:00 +0100

Conclusion: Inguinal dissections with preservation of the fascia lata for penile carcinoma patients without extranodal extension is as effective as the classic dissection technique but decreases complications related to groin dissection. (Source: Urology)

Comparison of robot-assisted and laparoscopic pelvic lymphadenectomy in penile cancer patients with stage N2/N3 inguinal disease

International Journal of Surgery — Thu, 18 Jul 2013 11:19:04 +0100

Primary Prevention and Vaccination for Penile CancerPrimary Prevention and Vaccination for Penile Cancer

Medscape Today Headlines — Mon, 15 Jul 2013 13:05:20 +0100

This review reports on preventative measures to reduce penile cancer risk and the effectiveness of HPV vaccines. Therapeutic Advances in Urology (Source: Medscape Today Headlines)

Editorial Comment

The Journal of Urology — Mon, 15 Jul 2013 04:00:00 +0100

The authors report that carefully selected men with VLR prostate cancer are at lower risk for adverse pathological findings at radical prostatectomy than men with LR prostate cancer. However, restricting AS to only those with the lowest risk disease limits this option for men who may be good candidates for it. Also, the outcome of adverse pathological results, certainly when they are limited, such as minor changes in grade or stage, may not be an accurate surrogate for the definitive end point of prostate cancer specific or metastasis-free survival. In fact, recent results from Xia et al show that only 2.8% of men at LR on AS vs 1.6% at LR undergoing immediate radical prostatectomy would die of the disease in 20 years (reference 25 in article). The appropriate cohort of men for AS will con...

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Towards the eradication of HPV infection through universal specific vaccination

BMC Public Health - Latest articles — Thu, 11 Jul 2013 04:00:00 +0100

DiscussionA panel of experts convened to focus on scientific, medical, and economic studies, and on the achievements from health organizations' intervention programs on the matter. One of the goals was to discuss on the critical issues emerging from the ongoing global implementation of HPV vaccination. A second goal was to identify contributions which could overcome the barriers that impede or delay effective vaccination programs whose purpose is to eradicate the HPV infection both in women and men.SummaryThe reviewed studies on the natural history of HPV infection and related diseases in women and men, the increasing experience of HPV vaccination in women, the analysis of clinical effectiveness vs economic efficacy of HPV vaccination, are even more supportive of the economic sustainabilit...

Risk of human papillomavirus-related cancers among kidney transplant recipients and patients receiving chronic dialysis - an observational cohort study

BMC Nephrology — Mon, 08 Jul 2013 04:00:00 +0100

Conclusions: Persons with ESRD have excess risk of potentially vaccine-preventable human papillomavirus-related cancers. (Source: BMC Nephrology)

Acceptability of HPV vaccines and perceptions related to genital warts and penile/anal cancers among men who have sex with men in Hong Kong.

Vaccine — Mon, 08 Jul 2013 04:00:00 +0100

Authors: Wang Z, Lau JT, Lau M, Lai CH Abstract Men who have sex with men (MSM) are at high risk of contracting HIV and developing genital warts and penile/anal cancers. HPV vaccines are efficacious in preventing such HPV-related diseases among males and WHO recommends its use to young MSM. In a cross-sectional survey, 542 MSM were interviewed. After being briefed about the vaccines' efficacies and the market price, the prevalence of acceptability of HPV vaccination was 29.2%. Adjusted by significant background variables, perceived high/very high chances of contracting genital warts [adjusted odds ratio (AOR)=2.04, 95%CI=1.11-3.72] and penile/anal cancers (AOR=1.89, 95%CI=1.09-3.29) among local MSM, perceived moderately high mortality rate of penile/anal cancers (AOR=1.78, 95%CI=1....

Combined Inflatable Penile Prosthesis-Artificial Urinary Sphincter Implantation: No Increased Risk of Adverse Events Compared to Single or Staged Device Implantation

The Journal of Urology — Mon, 08 Jul 2013 04:00:00 +0100

Purpose: Little data exist on the outcome of combined inflatable penile prosthesis and artificial urinary sphincter insertion for erectile dysfunction and stress urinary incontinence. We assessed patient outcomes for combined vs single device implantation at a single institution.Materials and Methods: We retrospectively reviewed the records of all patients who underwent inflatable penile prosthesis and artificial urinary sphincter insertion at our hospital from January 2000 to December 2011. A total of 55 combined procedures were performed compared to the single insertion of 336 inflatable penile prostheses and 279 artificial urinary sphincters.Results: The surgical approach consisted of penoscrotal incisions for inflatable penile prostheses and transperineal incisions for artificial urina...

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Pro-Circumcision Culturally Biased, Not Scientific: Experts

Psychology Today Parenting Center — Sun, 07 Jul 2013 17:17:19 +0100

Last year the American Academy of Pediatrics put out a report that infant circumcision is beneficial to infant boys for several reasons, including preventing penile cancer. But infants do not get penile cancer. The arguments were flawed and biased according to a group of doctors representing medical organizations outside the USA.read more (Source: Psychology Today Parenting Center)

HPV frequency in penile carcinoma of Mexican patients: important contribution of HPV16 European variant.

International Journal of Clinical and Experimental Pathology — Sat, 06 Jul 2013 15:10:02 +0100

Authors: López-Romero R, Iglesias-Chiesa C, Alatorre B, Vázquez K, Piña-Sánchez P, Alvarado I, Lazos M, Peralta R, González-Yebra B, Romero A, Salcedo M Abstract The role of human papillomavirus (HPV) infection in penile carcinoma (PeC) is currently reported and about half of the PeC is associated with HPV16 and 18. We used a PCR-based strategy by using HPV general primers to analyze 86 penile carcinomas paraffin-embedded tissues. Some clinical data, the histological subtype, growth pattern, and differentiation degree were also collected. The amplified fragments were then sequenced to confirm the HPV type and for HPV16/18 variants. DNA samples were also subjected to relative real time PCR for hTERC gene copy number. Some clinical data were also collected. Global HPV frequency ...

Cytosolic phosphorylated EGFR is predictive of recurrence in early stage penile cancer patients: a retropective study

Journal of Translational Medicine — Tue, 02 Jul 2013 04:00:00 +0100

Conclusion: It is of primary importance to identify patients with N0-1 disease who are at increased risk of recurrence, as they do not normally receive any adjuvant therapy. Expression of p-EGFR was found in this series to be strongly related to increase risk of recurrence and shorter overall survival. This finding is consistent with the role of p-EGFR in other solid malignancies. Integration of p-EGFR with classic prognostic factors and other histology markers should be pursued to establish optimal adjuvant therapy for N0-1 PC patients. (Source: Journal of Translational Medicine)

Penile Cancer: Organ‐sparing techniques

BJU International — Mon, 01 Jul 2013 04:00:00 +0100

ConclusionsThere were no randomized studies comparing preserving and ablative techniques. The majority of studies consisted of retrospective cohorts. The quality of evidence is level 3 at best. Cancer specific survival is similar in penis preserving and ablative approaches for low stage disease. Penile preservation is superior in functional and cosmetic outcomes and should be offered as a primary treatment modality in men with low stage penile cancer. (Source: BJU International)

The psychology of penile cancer from presentation to rehabilitation

International Journal of Urological Nursing — Mon, 01 Jul 2013 04:00:00 +0100

ABSTRACT Penile cancer is an uncommon, gender‐specific, malignancy that has the potential to profoundly affect physical, social, sexual and psychological functions. For most patients the method of treatment is surgery. The degree of surgical intervention is dependent on the stage of the disease at presentation. To date, relatively little is known about the impact of penile cancer surgery on psychological function and overall quality of life in men. Understanding the outcomes of treatment will influence the development of optimal methods of rehabilitation. This paper provides an outline of the context of two reviews of the existing literature: (i) a systematic review of the quantitative literature and (ii) a meta‐synthesis of the qualitative literature. The implications for clinical pra...

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Predictors of Pathological Progression among Men with Localized Prostate Cancer Undergoing Active Surveillance: a Sub-Analysis of the REDEEM Study

The Journal of Urology — Mon, 01 Jul 2013 04:00:00 +0100

Purpose: We identify risk factors for pathological progression among men on active surveillance in the REDEEM (REduction by Dutasteride of clinical progression Events in Expectant Management trial).Materials and Methods: REDEEM was a 3-year, randomized, double-blind study of patients in 65 North American academic centers. Eligible men were 48 to 82 years old, with low risk prostate cancer (T1c–T2a), Gleason score 6 or less, 3 or fewer cores positive, tumor less than 50% of any 1 core, serum prostate specific antigen 11 ng/ml or less, life expectancy greater than 5 years and undergoing active surveillance. Entry biopsies (10 cores or more) were required. The analysis included 276 patients with 1 biopsy or more after the start of study treatment. Patients received dutasteride 0.5 mg per da...

Extraprostatic Extension into Periprostatic Fat is a More Important Determinant of Prostate Cancer Recurrence than an Invasive Phenotype

The Journal of Urology — Mon, 01 Jul 2013 04:00:00 +0100

Purpose: Although micrometastasis development correlates closely with the depth of invasion of many tumor types, it is unclear whether invasion into but not through the prostatic pseudocapsule has a negative impact on prognosis, similar to extraprostatic extension. We defined the impact of pseudocapsular invasion on the risk of post-prostatectomy biochemical recurrence.Materials and Methods: Patients with pT2-3a prostate cancer were identified from a prospectively recorded database. Those with pT2 disease were categorized according to pseudocapsular invasion presence or absence. The impact of pseudocapsular invasion on biochemical recurrence was determined by univariable and multivariable Cox regression analysis.Results: In a cohort of 1,338 patients we identified 595 with organ confined c...

Erectile Dysfunction In Men Treated For Testicular Cancer

BJU International — Sun, 30 Jun 2013 15:15:04 +0100

ConclusionsMen with TC presenting with ED after treatment appear to uniformly have normal erectile hemodynamics, suggesting adrenaline‐mediated ED. While the majority of TC survivors with ED respond successfully to PDE5i, a significant minority do not. (Source: BJU International)

Sexual outcomes after organ potency-sparing surgery and glans reconstruction in patients with penile carcinoma

Indian Journal of Urology — Wed, 26 Jun 2013 04:00:00 +0100

Conclusions: Potency sparing-sparing surgical treatments have a positive impact on a wide spectrum of the patient's life including family relationships, and social and working conditions. (Source: Indian Journal of Urology)

Viagra prices to drop – sales expected to grow

NHS News Feed — Mon, 24 Jun 2013 15:06:00 +0100

Today the media reports that the patent on Viagra has come to an end. This means that other drug companies can now produce their own versions of the drug. Viagra is the brand name the pharmaceutical company Pfizer uses for the drug sildenafil citrate, which is used to treat erectile dysfunction. Viagra was designed to treat high blood pressure and angina. Researchers found that it was not particularly effective for either condition but that it did lead to sustained erections, as a result of temporarily increasing blood flow to the penis. Manufacturers Pfizer have held the exclusive right to market the drug (known as a patent) for the past 15 years since it was licensed in 1998. Now that the patent has expired other pharmaceutical companies will be able to market their own versions of sil...

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Re: Standardized Analysis of Frequency and Severity of Complications after Robot-Assisted Radical Cystectomy

The Journal of Urology — Mon, 24 Jun 2013 04:00:00 +0100

B. E. Yuh, M. Nazmy, N. H. Ruel, J. T. Jankowski, A. R. Menchaca, R. R. Torrey, J. A. Linehan, C. S. Lau, K. G. Chan and T. G. Wilson City of Hope National Cancer Center, Duarte, California (Source: The Journal of Urology)

Complications With Inguinal Lymphadenectomy for Penile CancerComplications With Inguinal Lymphadenectomy for Penile Cancer

Medscape Medical News Headlines — Thu, 20 Jun 2013 16:00:00 +0100

Morbidity associated with inguinal lymphadenectomy in patients with penile carcinoma has declined, and is 'reasonable' considering the potential benefit. Reuters Health Information (Source: Medscape Medical News Headlines)

Erectile dysfunction after radiotherapy for prostate cancer: a model assessing the conflicting literature on dose–volume effects

International Journal of Impotence Research — Thu, 20 Jun 2013 04:00:00 +0100

Erectile dysfunction after radiotherapy for prostate cancer: a model assessing the conflicting literature on dose–volume effects International Journal of Impotence Research advance online publication, June 20 2013. doi:10.1038/ijir.2013.28 Authors: E Rivin del Campo, K Thomas, V Weinberg & M Roach (Source: International Journal of Impotence Research)

Incremental Value of Magnetic Resonance Imaging for Clinically High Risk Prostate Cancer in 922 Radical Prostatectomies

The Journal of Urology — Thu, 20 Jun 2013 04:00:00 +0100

Purpose: We investigated the incremental value of magnetic resonance imaging in addition to clinical variables for predicting pathological outcomes and disease recurrence in patients with clinically high risk prostate cancer.Materials and Methods: A total of 922 consecutive patients with clinically high risk prostate cancer underwent magnetic resonance imaging before radical prostatectomy. We created multivariate logistic regression and Cox proportional hazards models with clinical variables only or combined with magnetic resonance imaging data to predict pathological outcomes and biochemical recurrence. The models were compared using ROC curves and the Harrell concordance index.Results: The proportion of patients with pathological extracapsular extension, seminal vesicle invasion and lymp...

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Can Magnetic Resonance-Ultrasound Fusion Biopsy Improve Cancer Detection in Enlarged Prostates?

The Journal of Urology — Wed, 19 Jun 2013 04:00:00 +0100

Purpose: Patients with an enlarged prostate and suspicion of prostate cancer pose a diagnostic dilemma. The prostate cancer detection rate of systematic 12-core transrectal ultrasound guided biopsy is between 30% and 40%. For prostates greater than 40 cc this decreases to 30% or less. Magnetic resonance-ultrasound fusion biopsy has shown superior prostate cancer detection rates. We defined the detection rate of magnetic resonance-ultrasound fusion biopsy in men with an enlarged prostate gland.Materials and Methods: We retrospectively analyzed the records of patients who underwent multiparametric prostate magnetic resonance imaging followed by magnetic resonance-ultrasound fusion biopsy at our institution. Whole prostate volumes were calculated using magnetic resonance imaging reconstructio...

Differential gene hypermethylation in genital lichen sclerosus and cancer: a comparative study

Histopathology — Mon, 17 Jun 2013 04:00:00 +0100

ConclusionsGene hypermethylation is a common event in penile LS and occurs approximately as frequently as in vulvar LS. Certain genes can be hypermethylated as an early or late event in LS or cancer, respectively. This suggests a possible sequential role for these alterations in the transition from benign to malignant lesions.This article is protected by copyright. All rights reserved. (Source: Histopathology)

Sperm Concentration, Testicular Volume and Age Predict Risk of Carcinoma In Situ in Contralateral Testis of Men with Testicular Germ Cell Cancer

The Journal of Urology — Mon, 17 Jun 2013 04:00:00 +0100

Conclusions: The combined information on sperm concentration, age and contralateral testis volume predict the risk of contralateral carcinoma in situ in patients with unilateral testicular germ cell tumor. The proposed models may facilitate selection of patients with testicular germ cell tumor for contralateral testicular biopsy at the time of orchiectomy if this is not routinely done. (Source: The Journal of Urology)

Surgical Management of a Locally Advanced Symptomatic Recurrence of Penile Sarcoma Secondary to Prostate Brachytherapy

International Braz J Urol — Mon, 17 Jun 2013 03:18:22 +0100

Conclusion As highlighted in the present video, the treatment of a symptomatic sarcoma local recurrence contiguously involving the penis can be successfully managed provided the patient is informed of the potential morbidity and psychosocial implications imparted by performing a total penectomy and adjacent organ resection. (Source: International Braz J Urol)

Pathological Examination of Radical Prostatectomy Specimens in Men with Very Low Risk Disease at Biopsy Reveals Distinct Zonal Distribution of Cancer in Black American Men

The Journal of Urology — Fri, 14 Jun 2013 04:00:00 +0100

Purpose: Of men with very low risk prostate cancer at biopsy recent evidence shows that black American men are at greater risk for adverse oncologic outcomes after radical prostatectomy. We studied radical prostatectomy specimens from black and white men at very low risk to determine whether there are systematic pathological differences.Materials and Methods: Radical prostatectomy specimens were evaluated in men with National Comprehensive Cancer Network® (NCCN) very low risk prostate cancer. At diagnosis all men underwent extended biopsy sampling (10 or more cores) and were treated in the modern Gleason grade era. We analyzed tumor volume, grade and location in 87 black and 89 white men. For each specimen the dominant nodule was defined as the largest tumor with the highest grade.Results...

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Modified Endoscopic Left Inguinal Lymphadenectomy.

Actas Urologicas Espanolas — Wed, 12 Jun 2013 04:00:00 +0100

CONCLUSION: The endoscopic inguinal lymphadenectomy is feasible in clinical practice. New studies with a greater number of patients and long-term follow-up may confirm the oncological efficacy and possible lower morbidity of these new approach. PMID: 23768501 [PubMed - as supplied by publisher] (Source: Actas Urologicas Espanolas)

Validation of a Genomic Classifier that Predicts Metastasis Following Radical Prostatectomy in an At Risk Patient Population

The Journal of Urology — Wed, 12 Jun 2013 04:00:00 +0100

We report a validation study of a genomic classifier that predicts metastasis after radical prostatectomy in a high risk population.Materials and Methods: A case-cohort design was used to sample 1,010 patients after radical prostatectomy at high risk for recurrence who were treated from 2000 to 2006. Patients had preoperative prostate specific antigen greater than 20 ng/ml, Gleason 8 or greater, pT3b or a Mayo Clinic nomogram score of 10 or greater. Patients with metastasis at diagnosis or any prior treatment for prostate cancer were excluded from analysis. A 20% random sampling created a subcohort that included all patients with metastasis. We generated 22-marker genomic classifier scores for 219 patients with available genomic data. ROC and decision curves, competing risk and weighted r...

Radical Open Inguinal Lymphadenectomy for Penile Carcinoma: Surgical Technique, Early Complications and Late Outcomes

The Journal of Urology — Wed, 12 Jun 2013 04:00:00 +0100

Conclusions: Our contemporary series includes a lower incidence of complications, such as wound infection, skin flap necrosis, lymphocele and lymphedema. To our knowledge this series represents the lowest incidence rate of complications described in the international literature. (Source: The Journal of Urology)

mTOR Signaling Pathway in Penile Squamous Cell Carcinoma: pmTOR and peIF4E Over Expression Correlate with Aggressive Tumor Behavior

The Journal of Urology — Wed, 12 Jun 2013 04:00:00 +0100

Conclusions: Activation of mTOR signaling may contribute to penile squamous cell carcinoma progression and aggressive behavior. Targeting mTOR or its downstream signaling targets, such as peIF4E, may be a valid therapeutic strategy. (Source: The Journal of Urology)

Editorial Comment

The Journal of Urology — Tue, 11 Jun 2013 04:00:00 +0100

These authors present an interesting approach using prebiopsy MP-MRI to detect anterior cancer suspicious regions. Anterior PCa is less likely to be sampled by transrectal ultrasound guided biopsy, leading to an increased incidence of PCa in these regions after negative transrectal ultrasound guided biopsy (reference 9 in article). In the current series MP-MRI revealed an anterior cancer suspicious region in 29% of cases with no PCa on 12-core transrectal ultrasound guided biopsy, indicating the need for anterior biopsy to rule out PCa. On the other hand, 14% of men with no cancer suspicious region on prebiopsy MP-MRI harbored significant PCa. At this point we can only conclude that prebiopsy MP-MRI is a promising adjunct to define the need for anterior sampling (using a schematic transper...

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Is Penile Preservation of Distal Corporal Invasive Penile Cancer Sufficient Treatment?

The Journal of Urology — Fri, 07 Jun 2013 04:00:00 +0100

Traditionally treatment of invasive penis cancer stage T2 or greater consisted of some form of amputation. This is oncologically sound in a period characterized by late presentation and high incidence of phimosis preventing early detection. Moreover, historical data labeled patients with penile cancer in lower socioeconomic classes with serious neglect of the first signs of cancer, necessitating an immediate solution, without too many choices. Changes in first presentation and patient characteristics, at least in Western Europe, led the way to less ablative surgery. So the question whether penile preservation of distal corporal invasive penile cancer is sufficient treatment is understandable and timely. (Source: The Journal of Urology)

Whole‐mount evaluation of penectomies for penile cancer: feasibility, cost and comparison to routine sectioning

Histopathology — Thu, 06 Jun 2013 04:00:00 +0100

ConclusionsWhole‐mounting is a feasible technique for penectomy that can be utilized with minimal increased cost and turnaround time, and may improve staging. Institutions in which whole‐mounting is already established for other organs, such as prostate, may wish to consider utilizing this format for penectomy specimens. (Source: Histopathology)

Re: Editorial Comment to Circumcision related to urinary tract infections, sexually transmitted infections, human immunodeficiency virus infections, and penile and cervical cancer

International Journal of Urology — Wed, 05 Jun 2013 04:00:00 +0100

(Source: International Journal of Urology)

Michael Douglas, oral sex and throat cancer

NHS News Feed — Mon, 03 Jun 2013 14:32:00 +0100

The actor Michael Douglas discussed his recent throat cancer treatment in an interview with The Guardian this weekend, and revealed that he blamed oral sex for his condition. When asked by the newspaper if his throat cancer was caused by his many years of heavy drinking and smoking he was quoted as saying: "No, because without wanting to get too specific this particular cancer is caused by HPV, which actually comes about from cunnilingus." Could he be right? Here are some facts about HPV, oral sex and cancer risk. What is HPV? The human papilloma virus (HPV) is the name for a group of viruses that affect your skin and the moist membranes lining your body, for example, in your cervix, anus, mouth and throat. There are more than 100 types of HPV – 40 of which can affect the ...

Penile Nodules: Whose Problem?

Gastroenterology — Mon, 03 Jun 2013 04:00:00 +0100

Question: A 65-year-old man visited our department during postoperative radiotherapy for an anorectal carcinoma (ARC) with painful penile induration. There were no signs of fever, dysuria, or inguinal lymphadenopathy. On examination, multiple discrete nodules up to 10 mm in diameter were palpable under the prepuce. Three months before the present consultation, the patient underwent abdominoperineal resection for locally advanced ARC. Preoperative radiographic examination could not detect these lesions. Histologic diagnosis of the anorectal lesion revealed a moderately to poorly differentiated adenocarcinoma with a T3 tumor of the positive adventitial margin, resulting in Dukes’ classification B. Laboratory data, including levels of tumor markers, were within the normal range. Serologic t...

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Population Based Study of Use and Determinants of Active Surveillance and Watchful Waiting for Low and Intermediate Risk Prostate Cancer

The Journal of Urology — Fri, 31 May 2013 04:00:00 +0100

Conclusions: Deferred treatment for low and intermediate risk prostate cancer was frequently used in Sweden. Dissociating diagnosis from treatment in men with a low risk of progression can decrease the rate of overtreatment. (Source: The Journal of Urology)

Adenocarcinoma of the Prostate with Gleason Score 9-10 on Core Biopsy: Correlation with Findings at Radical Prostatectomy and Prognosis

The Journal of Urology — Fri, 31 May 2013 04:00:00 +0100

Purpose: There is a paucity of data on the prognosis after radical prostatectomy for Gleason score 9-10 disease on needle biopsy. To our knowledge we report the largest study to date to specifically analyze the correlation of Gleason score 9-10 on needle core biopsy with radical prostatectomy outcomes.Materials and Methods: We identified 259 men with Gleason score 9-10 on biopsy who underwent radical prostatectomy from 1987 to 2012 at our institution. Preoperative variables analyzed were age, race, preoperative prostate specific antigen, adenocarcinoma site, perineural invasion, number of total biopsy cores, number of total positive cores, number of positive cores with Gleason score 9-10, maximum percent of core length with Gleason score 9-10 and maximum percent of adenocarcinoma overall. ...

Tumor Lesion Diameter on Diffusion Weighted Magnetic Resonance Imaging Could Help Predict Insignificant Prostate Cancer in Patients Eligible for Active Surveillance: Preliminary Analysis

The Journal of Urology — Thu, 30 May 2013 04:00:00 +0100

Conclusions: Our analysis demonstrates that the simple measurement of the diameter of suspicious tumor lesions on diffusion weighted magnetic resonance imaging could improve the prediction of insignificant prostate cancer in candidates for active surveillance. (Source: The Journal of Urology)