MedWorm: Testicular Cancer

Risk Factors for Loss to Follow-up During Active Surveillance of Patients with Stage I Seminoma

Japanese Journal of Clinical Oncology — Tue, 01 Apr 2014 00:00:00 +0100

Conclusions The loss to follow-up rates beyond 5 years were unsatisfactorily high during active surveillance. Further approaches to improve the quality of active surveillance are needed, especially for high-risk patients such as those of younger age. (Source: Japanese Journal of Clinical Oncology)

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V10-02 robotic retroperitoneal lymph node dissection for stage 1 non-seminomatous testicular cancer: technically feasible with left and right modified templates

The Journal of Urology — Tue, 01 Apr 2014 00:00:00 +0100

(Source: The Journal of Urology)

Mp10-10 surgical management of testicular cancer patients with complex postchemotherapy residual masses: single centre experience

The Journal of Urology — Tue, 01 Apr 2014 00:00:00 +0100

(Source: The Journal of Urology)

Mp10-06 lower-than-expect relapse rate among contemporary patients with clinical stage i seminoma managed on surveillance

The Journal of Urology — Tue, 01 Apr 2014 00:00:00 +0100

(Source: The Journal of Urology)

Mp10-05 influence of race on outcomes in testicular cancer: analysis of 75902 patients in the national cancer data base

The Journal of Urology — Tue, 01 Apr 2014 00:00:00 +0100

(Source: The Journal of Urology)

Pd5-06 retrocrural dissection during retroperitoneal lymph node dissection for testicular cancer

The Journal of Urology — Tue, 01 Apr 2014 00:00:00 +0100

(Source: The Journal of Urology)

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Pd5-04 united states trends in patterns of care in clinical stage i testicular cancer: results from the national cancer data base (1998-2011)

The Journal of Urology — Tue, 01 Apr 2014 00:00:00 +0100

(Source: The Journal of Urology)

Pd5-02 the impact of lack of insurance on testicular cancer prognosis in young patients in the united states. data from the seer data base

The Journal of Urology — Tue, 01 Apr 2014 00:00:00 +0100

(Source: The Journal of Urology)

Developmental Expression of Musashi-1 and Musashi-2 RNA-Binding Proteins During Spermatogenesis: Analysis of the Deleterious Effects of Dysregulated Expression.

Biology of Reproduction — Wed, 26 Mar 2014 00:00:00 +0100

Authors: Sutherland JM, Fraser BA, Sobinoff AP, Pye VJ, Davidson TL, Siddall NA, Koopman P, Hime GR, McLaughlin EA Abstract Spermatogenesis is a complex developmental process whereby diploid spermatogenic stem cells become haploid and undergo a series of morphological changes to produce physically mature spermatozoa. Crucial to this process are a number of RNA binding proteins, responsible for the post-transcriptional control of essential mRNAs; particularly pertinent to the two periods of inactive transcription which occur in spermatogenesis. One such group of RNA binding proteins is the Musashi family, specifically Musashi-1 (MSI1) and Musashi-2 (MSI2), which act as key translational regulators in various stem cell populations and have been linked with the induction of tumorigene...

Nurses in 'vanguard' of fresh attempt to reach male cancer patients

Nursing Times Breaking News — Tue, 25 Mar 2014 11:55:00 +0100

Nurses are hitting the road in a dedicated mobile support unit for men with prostate or testicular cancer in Wales. (Source: Nursing Times Breaking News)

Nurses in 'vanguard' of attempt to reach male cancer patients

Nursing Times Breaking News — Tue, 25 Mar 2014 11:55:00 +0100

Nurses are hitting the road in a dedicated mobile support unit for men with prostate or testicular cancer in Wales. (Source: Nursing Times Breaking News)

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Analysis of treatment results in primary germ cell tumours with mediastinal location: own experience.

Pneumonologia i Alergologia Polska — Sat, 15 Mar 2014 03:30:02 +0100

CONCLUSIONS: Primary mediastinal germ cell tumours have worse prognosis than do those with gonadal location. Based on our observations and review of the literature, it can be concluded that the results of treatment of non-seminoma type germ cell tumours with primary mediastinal location remain poor. Patients who develop early recurrence or progression during first-line chemotherapy are particularly at risk of unfavourable outcome. Identification of new standards of treatment in tumours resistant to cisplatin require further studies evaluating the effectiveness of new generation cytostatic drugs. PMID: 24615195 [PubMed - in process] (Source: Pneumonologia i Alergologia Polska)

Testicular Cancer

MedicineNet Cancer General — Fri, 14 Mar 2014 07:00:00 +0100

Title: Testicular CancerCategory: Diseases and ConditionsCreated: 12/31/1997 12:00:00 AMLast Editorial Review: 3/14/2014 12:00:00 AM (Source: MedicineNet Cancer General)

Circulating tumor cells in patients with testicular germ cell tumors.

Clinical Cancer Research — Fri, 14 Mar 2014 00:00:00 +0100

CONCLUSIONS: The inclusion of germ-cell specific markers improves CTCs detection in GCTs. CTCs occur frequently in patients with more aggressive disease, and there is a gradient of CTCs with decreasing numbers from the tumor-draining vein to the PB vessels. PMID: 24634372 [PubMed - as supplied by publisher] (Source: Clinical Cancer Research)

Well: Young, Gay and Blaming Myself for Cancer

NYT Health — Thu, 13 Mar 2014 18:48:01 +0100

Convinced I had brought this cancer on myself, the floodgates of memory and self-blame poured out. My perceived “failings” ranged from being gay to being molested as a child. (Source: NYT Health)

Taking my health back from cancer

CNN.com - Health — Mon, 10 Mar 2014 22:28:15 +0100

Before he was diagnosed with testicular cancer, Jamil Nathoo was healthy and strong. Now he's in remission, and ready to tackle a triathlon. (Source: CNN.com - Health)

Evaluation of frozen section results in patients who have suspected testicular masses: a preliminary report.

Urology Journal — Mon, 10 Mar 2014 05:20:02 +0100

Conclusion: Our preliminary report reveals that STM tend to be benign rather than malignant in nature. Also, a careful patient selection and an accurate FSA are crucial points for TSS and it has the potential to become the primary option in selected patients who have testicular lesions instead of the traditional method. PMID: 24595933 [PubMed - in process] (Source: Urology Journal)

Athlete: Cancer robbed me

CNN.com - Health — Fri, 07 Mar 2014 12:34:33 +0100

Before he was diagnosed with testicular cancer, Jamil Nathoo was healthy and strong. Now he's in remission, and ready to tackle a triathlon. (Source: CNN.com - Health)

Cancer robbed me of my health; now, I'm taking it back

CNN.com - Health — Fri, 07 Mar 2014 12:22:35 +0100

Before he was diagnosed with testicular cancer, Jamil Nathoo was healthy and strong. Now he's in remission, and ready to tackle a triathlon. (Source: CNN.com - Health)

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Small RNAs in the peripheral blood discriminate metastasized from non-metastasized seminoma

Molecular Cancer — Thu, 06 Mar 2014 00:00:00 +0100

Conclusions: Metastasized (either lymphogen or occult) seminoma can be completely discriminated from non-metastasized seminoma with a combination of two small RNAs measured in the peripheral blood. (Source: Molecular Cancer)

Educating Young Men About Testicular Cancer: Support for a Comprehensive Testicular Cancer Campaign

Journal of Health Communication — Mon, 03 Mar 2014 14:20:02 +0100

(Source: Journal of Health Communication)

Concomitant testicular seminoma and ectopic adrenal tissue of the cord in a 45-year-old male.

Canadian Urological Association Journal — Sat, 01 Mar 2014 00:00:00 +0100

We describe a case of concomitant seminoma and ectopic adrenal tissue of the spermatic cord occurring in an adult patient who had undergone orchidopexy as a child. PMID: 24678359 [PubMed] (Source: Canadian Urological Association Journal)

The utility of immunostaining for NUT, GAGE7 and NY‐ESO‐1 in the diagnosis of spermatocytic seminoma

Histopathology — Fri, 28 Feb 2014 00:00:00 +0100

ConclusionsAll three antibodies are variably sensitive for SS, and high specificity is attained when there is multifocal and strong nuclear labelling. (Source: Histopathology)

Effects of Four Chemotherapeutic Agents, Bleomycin, Etoposide, Cisplatin, and Cyclophosphamide, on DNA Damage and Telomeres in a Mouse Spermatogonial Cell Line.

Biology of Reproduction — Wed, 26 Feb 2014 00:00:00 +0100

Authors: Liu M, Hales BF, Robaire B Abstract Treatment with chemotherapeutics agents may induce persistent DNA damage in male germ cells with the possibility of long term consequences on fertility and progeny outcome. Telomeres, specialized structures at the physical ends of chromosomes, play an important role in the maintenance of genetic stability and in the response of somatic cells to anticancer drugs. Our objective was to test the hypothesis that exposure to bleomycin, etoposide, or cisplatin (the drugs used to treat testicular cancer) or cyclophosphamide (an anticancer agent and immunosuppressant) targets telomeres in the male germ line. C18-4 spermatogonial cells were exposed to bleomycin, etoposide, cisplatin or 4-hydroperoxycyclophosphamide (4OOH-CPA, a pre-activated analo...

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Reddit user discovered he had testicular cancer after graphic post got him to the doctor

the Mail online | Health — Thu, 20 Feb 2014 14:43:01 +0100

Colorado college student Taylor Tyree was browsing Reddit when he saw a post about a man who had a testicle removed because of testicular cancer. Realising he had similar symptoms, he got himself checked out - and was diagnosed with the same disease. (Source: the Mail online | Health)

Differential Response to Abiraterone Acetate and Di-n-butyl Phthalate in an Androgen-Sensitive Human Fetal Testis Xenograft Bioassay

Toxicological Sciences — Thu, 20 Feb 2014 00:00:00 +0100

In utero exposure to antiandrogenic xenobiotics such as di-n-butyl phthalate (DBP) has been linked to congenital defects of the male reproductive tract, including cryptorchidism and hypospadias, as well as later life effects such as testicular cancer and decreased sperm counts. Experimental evidence indicates that DBP has in utero antiandrogenic effects in the rat. However, it is unclear whether DBP has similar effects on androgen biosynthesis in human fetal testis. To address this issue, we developed a xenograft bioassay with multiple androgen-sensitive physiological endpoints, similar to the rodent Hershberger assay. Adult male athymic nude mice were castrated, and human fetal testis was xenografted into the renal subcapsular space. Hosts were treated with human chorionic gonadotropin fo...

Management of the primary malignant mediastinal germ cell tumors: experience with 54 patients

Diagnostic Pathology — Wed, 19 Feb 2014 00:00:00 +0100

Conclusions: It could be concluded that a complete surgical resection of PMMGCT after chemoradiotherapy showed favorable long-term survival. Patients with pure seminomas have a better prognosis compared with that with NSGCT.Virtual slides: The virtual slides for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1676987232116837. (Source: Diagnostic Pathology)

Re: Testicular Cancer in Europe and the USA: Survival Still Rising among Older Patients

The Journal of Urology — Wed, 19 Feb 2014 00:00:00 +0100

(Source: The Journal of Urology)

Assessing calibration of multinomial risk prediction models

Statistics in Medicine — Tue, 18 Feb 2014 00:00:00 +0100

Calibration, that is, whether observed outcomes agree with predicted risks, is important when evaluating risk prediction models. For dichotomous outcomes, several tools exist to assess different aspects of model calibration, such as calibration‐in‐the‐large, logistic recalibration, and (non‐)parametric calibration plots. We aim to extend these tools to prediction models for polytomous outcomes.We focus on models developed using multinomial logistic regression (MLR): outcome Y with k categories is predicted using k − 1 equations comparing each category i (i = 2, … ,k) with reference category 1 using a set of predictors, resulting in k − 1 linear predictors. We propose a multinomial logistic recalibration framework that involves an MLR fit where Y is predicted u...

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Testicular cancer survivor's bid to raise money for the hospital that saved his life: 24 hours non-stop cycling, 350 miles on foot and eight hours kayaking

the Mail online | Health — Fri, 14 Feb 2014 10:22:01 +0100

EXCLUSIVE: Charlie Penrose, 29, from London, is raising money for King's College Hospital as a way of thanking the staff for looking after him. (Source: the Mail online | Health)

Longitudinal Serum Testosterone, Luteinizing Hormone, and Follicle-Stimulating Hormone Levels in a Population-Based Sample of Long-Term Testicular Cancer Survivors [Urologic Oncology]

Journal of Clinical Oncology — Fri, 14 Feb 2014 00:00:00 +0100

Conclusion Long-term TCSs are at risk of premature hormonal aging. Our findings may pertain to cancer survivors in general, underlining the importance of extended follow-up. (Source: Journal of Clinical Oncology)

Is ex vivo microdissection testicular sperm extraction indicated for infertile men undergoing radical orchiectomy for testicular cancer? Case report and literature review

Fertility and Sterility — Thu, 13 Feb 2014 00:00:00 +0100

Conclusion(s): We propose that microdissection TESE should be considered the preferred sperm retrieval technique at the time of radical orchiectomy in men with coexistent nonobstructive azoospermia and testicular cancer. (Source: Fertility and Sterility)

From zero to full hysterectomy in a few short weeks – Lucy’s Story

The Hysterectomy Association — Wed, 12 Feb 2014 16:24:02 +0100

I went from nothing to a full hysterectomy in just a few short weeks. I can still see the consultant’ s fountain pen inscribing the words “Total abdominal hysterectomy” in my hospital record, as I looked on in total shock. A few months back I had never even set foot in a gynaecology department, except for the birth of my two children, how had it come to this? I had never had any problems to speak of, not even morning sickness when I was pregnant, no major stuff with periods. I sat in stunned confusion.. I say no problems with periods, a few months before this moment, my periods were becoming increasingly erratic, which I put down to the approach of menopause ( I was 48 when this happened) as did the GP and practice nurse when I mentioned it at the time of routine cervical...

Pancreatic Cancer Action: why we ran a controversial ad campaign

Guardian Unlimited Science — Wed, 12 Feb 2014 12:36:00 +0100

Ali Stunt, chief executive of PCA, says that despite widespread criticism, the campaign achieved its aimsAny type of cancer is a horrible disease but, thankfully, funding and campaigning has seen the survival rates for many types of the disease improve tremendously in the last few decades.However, pancreatic cancer, the UK's fifth biggest killer among cancers, has been little known, poorly understood and chronically underfunded, which goes some way to explaining why survival rates have not improved in 40 years.While no early detection method exists for the cancer, the key to changing survival figures is early diagnosis. If a patient is diagnosed in time for them to receive surgery, their chance of survival increases tenfold.A recent patient survey found that more than 50% of pancreatic can...

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Imaging diagnosis – seminoma causing liver compression in a spur‐thighed tortoise (testudo graeca)

Veterinary Radiology and Ultrasound — Mon, 10 Feb 2014 00:00:00 +0100

A 13‐year‐old male spur‐thighed tortoise (Testudo graeca) was presented with anorexia, apathy, and prolapse of penile tissue. Ultrasonography revealed a large heterogeneous mass in the coelomic cavity, and fine‐needle aspiration demonstrated sperm. Magnetic resonance imaging showed a sharply defined mass originating from the left testis. Appearance and signal intensities were similar to those reported in testicular neoplasms in humans, in particular sharing similarities with seminomas. Necropsy results and histopathological findings were consistent with a seminoma. To the authors’ knowledge this is the first report of the diagnosis of testicular neoplasia in a reptile using imaging techniques. (Source: Veterinary Radiology and Ultrasound)

Pharmaceutical and pharmacological approaches for bioavailability enhancement of etoposide.

Journal of Biosciences — Sat, 08 Feb 2014 18:40:05 +0100

Authors: Najar IA, Johri RK Abstract Etoposide, a semi-synthetic derivative of podophyllotoxin, is one of the most active and useful antineoplastic agent used routinely in firstline combination chemotherapy of testicular cancer, small-cell lung cancer and non-Hodgkin's lymphoma. Etoposide displays narrow therapeutic index, erratic pharmacokinetics and dose individualization that needs to be achieved for overcoming inter- and intra-patient variability (25-80 percent), so as to maintain proper drug exposure within a therapeutic range. Etoposide posses high plasma protein binding (97 percent) and is degraded via complex metabolic pathways. The main pharmacokinetic determinants of etoposide are still not completely defined in order to optimize the pharmaco-therapeutic parameters includ...

Stat Bite Testicular Cancer Incidence and Mortality By Age In The U.S.

JNCI — Fri, 07 Feb 2014 00:00:00 +0100

(Source: JNCI)

Debates Emerge Over Active Surveillance in Testicular Cancer

JNCI — Fri, 07 Feb 2014 00:00:00 +0100

(Source: JNCI)

Stat Bite Testicular Cancer Incidence and Mortality by Age in the United States

JNCI — Fri, 07 Feb 2014 00:00:00 +0100

(Source: JNCI)

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New combined therapy to treat cancer proposed

ScienceDaily Headlines — Thu, 06 Feb 2014 18:38:22 +0100

Researchers have discovered how etoposide -- a drug widely used in the treatment of lung and testicular cancers, leukemias and brain tumors -- could increase its efficiency and specificity in combination with other compounds that interfere with cell division. (Source: ScienceDaily Headlines)

CNIO researchers propose a new combined therapy to treat cancer

EurekAlert! - Cancer — Thu, 06 Feb 2014 05:00:00 +0100

(Centro Nacional de Investigaciones Oncologicas (CNIO)) Marcos Malumbres, a researcher at the Spanish National Cancer Research Centre, and his team have discovered how etoposide -- a drug widely used in the treatment of lung and testicular cancers, leukemias and brain tumors -- could increase its efficiency and specificity in combination with other compounds that interfere with cell division. The results are published today in the journal Cell Reports. (Source: EurekAlert! - Cancer)

Expression of human chorionic gonadotropin in testicular germ cell tumors.

Urologic Oncology — Mon, 03 Feb 2014 00:00:00 +0100

CONCLUSION: Trophoblastic tissue expresses hCG, hCG-h, and free subunits together whereas seminoma tissue occasionally expresses hCGβ. This difference might aid in differential diagnosis of some difficult-to-classify cases. PMID: 24502963 [PubMed - as supplied by publisher] (Source: Urologic Oncology)

Testicular microlithiasis: Prevalence and association with primary testicular neoplasm

Journal of Clinical Ultrasound — Sat, 01 Feb 2014 00:00:00 +0100

ConclusionsAdvances in ultrasound technology have led to an increased detection of testicular microlithiasis. We observed an eight‐fold increased prevalence of primary testicular neoplasm in patients with microlithiasis than in those without as well as an increased prevalence of germ cell tumors, particularly pure seminoma. © 2014 Wiley Periodicals, Inc. J Clin Ultrasound, 2014 (Source: Journal of Clinical Ultrasound)

Testicular microlithiasis: Is it linked with testicular cancer?

MayoClinic.com - Ask a Specialist — Fri, 31 Jan 2014 00:00:00 +0100

A Mayo Clinic specialist discusses the relationship between testicular microlithiasis and testicular cancer. (Source: MayoClinic.com - Ask a Specialist)

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A Hierarchical Frailty Model for Familial Testicular Germ-Cell Tumors

American Journal of Epidemiology — Fri, 31 Jan 2014 00:00:00 +0100

Using a 2-level hierarchical frailty model, we analyzed population-wide data on testicular germ-cell tumor (TGCT) status in 1,135,320 two-generational Norwegian families to examine the risk of TGCT in family members of patients. Follow-up extended from 1954 (cases) or 1960 (unaffected persons) to 2008. The first-level frailty variable was compound Poisson-distributed. The underlying Poisson parameter was randomized to model the frailty variation between families and was decomposed additively to characterize the correlation structure within a family. The frailty relative risk (FRR) for a son, given a diseased father, was 4.03 (95% confidence interval (CI): 3.12, 5.19), with a borderline significantly higher FRR for nonseminoma than for seminoma (P = 0.06). Given 1 affected brother, the life...

Pilot study evaluating testicular self-examination and its correlates in Hispanic college men.

Psychology of Men and Masculinity — Mon, 27 Jan 2014 05:00:00 +0100

This study assessed correlates of TSE in a Hispanic college student sample. Men (N = 165; mean age = 20.0 years, SD = 2.413) were recruited from a university located on the U.S.–México border. Participants completed a testicular cancer questionnaire and the Acculturation Rating Scale for Mexican Americans—II. Descriptive statistics were employed to assess the prevalence of TSE. A logistic regression analysis was conducted to assess factors hypothesized to be associated with TSE. Sixty-four percent reported never performing TSE. The logistic regression model was statistically significant, χ²(11) = 100.11, p R² = .67; increased likelihood of ever performing TSE was associated with being taught TSE (odds ratio [OR] = 20.44, p p p = .029), although the sample reported greater accultura...

Immunohistochemical Reevaluation of Carbonic Anhydrase IX (CA IX) Expression in Tumors and Normal Tissues.

American Journal of Clinical Pathology — Tue, 21 Jan 2014 15:15:47 +0100

Conclusions: These data demonstrate the diagnostic utility of CA IX in (1) differentiating CRCC from ChRCC and oncocytomas, (2) distinguishing low-grade CRCC from normal renal tubules in small samples, (3) separating ICC from HCC, and (4) identifying metastatic CRCC from other metastases with clear cell features. PMID: 24436269 [PubMed - in process] (Source: American Journal of Clinical Pathology)

Lymphonodal, pulmonary and pleural gliomatosis in a 42‐year old male with non‐seminomatous testicular germ cell cancer

Histopathology — Tue, 21 Jan 2014 00:10:06 +0100

Performance of formulae based estimates of glomerular filtration rate for carboplatin dosing in stage 1 seminoma

European Journal of Cancer — Tue, 21 Jan 2014 00:00:00 +0100

Abstract: Background: Single cycle carboplatin, dosed by glomerular filtration rate (GFR), is standard adjuvant therapy for stage 1 seminoma. Accurate measurement of GFR is essential for correct dosing. Isotopic methods remain the gold standard for the determination of GFR. Formulae to estimate GFR have improved the assessment of renal function in non-oncological settings. We assessed the utility of these formulae for carboplatin dosing.Methods: We studied consecutive subjects receiving adjuvant carboplatin for stage 1 seminoma at our institution between 2007 and 2012. Subjects underwent 51Cr-ethylene diamine tetra-acetic acid (EDTA) measurement of GFR with carboplatin dose calculated using the Calvert formula. Theoretical carboplatin doses were calculated from estimated GFR using Chronic ...

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Adjuvant Management of Stage I Classical Seminoma

Clinical Oncology — Fri, 17 Jan 2014 20:12:51 +0100

Introduction: Stage I seminoma is the most common presentation of testicular germ cell tumours. It has a greater than 98% 5 year OS, but surveillance studies suggest a relapse rate of 15–20% [1]. Three management approaches have been investigated: surveillance, adjuvant radiotherapy and carboplatin chemotherapy. This retrospective study compared three cohorts to assess changes in practice over 10 years in a regional cancer unit. (Source: Clinical Oncology)

Unravelling mechanisms of cisplatin sensitivity and resistance in testicular cancer

Expert Reviews in Molecular Medicine — Fri, 17 Jan 2014 13:10:40 +0100

Review Articles R. Koster, M.A.T.M. van Vugt, H. Timmer-Bosscha, J.A. Gietema, S. de Jong, Expert Reviews in Molecular Medicine, Volume 15, pp e12Abstract (Source: Expert Reviews in Molecular Medicine)

Re: Early Development of the Metabolic Syndrome after Chemotherapy for Testicular Cancer

The Journal of Urology — Thu, 16 Jan 2014 00:00:00 +0100

(Source: The Journal of Urology)

TFDP3 was expressed in coordination with E2F1 to inhibit E2F1-mediated apoptosis in prostate cancer.

Gene — Tue, 07 Jan 2014 05:00:00 +0100

Authors: Ma Y, Xin Y, Li R, Wang Z, Yue Q, Xiao F, Hao X Abstract TFDP3 has been previously identified as an inhibitor of E2F molecules. It has been shown to suppress E2F1-induced apoptosis dependent P53 and to play a potential role in carcinogenesis. However, whether it indeed helps cancer cells tolerate apoptosis stress in cancer tissues remains unknown. TFDP3 expression was assessed by RT-PCR, in situ hybridization and immunohistochemistry in normal human tissues, cancer tissues and prostate cancer tissues. The association between TFDP3 and E2F1 in prostate cancer development was analyzed in various stages. Apoptosis was evaluated with annexin-V and propidium iodide staining and flow-cytometry. The results show that, in 96 samples of normal human tissues, TFDP3 could be detected...

The Utility of Immunostaining for NUT, GAGE7, and NY‐ESO‐1 in the Diagnosis of Spermatocytic Seminoma

Histopathology — Mon, 06 Jan 2014 05:00:00 +0100

ConclusionsAll three antibodies are variably sensitive for SS, and high specificity is attained when there is multifocal and strong nuclear labeling.This article is protected by copyright. All rights reserved. (Source: Histopathology)

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Ochratoxin A: Developmental and Reproductive Toxicity—An Overview

Birth Defects Research Part B: Developmental and Reproductive Toxicology — Mon, 06 Jan 2014 05:00:00 +0100

Ochratoxin A (OTA) is nephrotoxic, hepatotoxic, reprotoxic, embryotoxic, teratogenic, neurotoxic, immunotoxic, and carcinogenic for laboratory and farm animals. Male and female reproductive health has deteriorated in many countries during the last few decades. A number of toxins in environment are suspected to affect reproductive system in male and female. OTA is one of them. OTA has been found to be teratogenic in several animal models including rat, mouse, hamster, quail, and chick, with reduced birth weight and craniofacial abnormalities being the most common signs. The presence of OTA also results in congenital defects in the fetus. Neither the potential of OTA to cause malformations in human nor its teratogenic mode of action is known. Exposure to OTA leads to increased embryo lethali...

Anti-Ma2-Associated Paraneoplastic Encephalitis in a Male Adolescent With Mediastinal Seminoma

Pediatric Neurology — Thu, 02 Jan 2014 00:00:00 +0100

A 19-year-old man presented with increasing fatigue, excessive daytime sleepiness, and headaches for 2 months. He was noted to have confusion, disorientation, and hallucinations. On examination, he was conscious and able to obey simple tasks. He was unable to speak fluently or answer questions and exhibited disinhibited behavior. Because of the patient's encephalopathy, we initiated neuroimaging with intravenous injection of a contrast agent, which revealed symmetric T2-weighted and fluid attenuation recovery hyperintensity in the hypothalamus, inferomedial frontal lobes, cingulate gyri, mesial temporal lobes, and dorsal midbrain (). These findings were suggestive of anti-Ma2-associated encephalitis, which initiated serum analysis for anti-Ma2 antibodies and screening for a primary tumor....

Testicular seminomatous mixed germ cell tumor with choriocarcinoma and teratoma with secondary somatic malignancy: a case report

BioMed Central — Wed, 01 Jan 2014 05:00:00 +0100

Conclusions: Prognosis of testicular tumor depends mainly on the clinical stage, but emergence of a sarcomatous component presents a challenge in the treatment of germ cell tumors and the histological subtype of this component can be used as a guide to specific chemotherapy in these patients. (Source: BioMed Central)

Fertility outcome of patients with testicular tumor: Before and after treatment.

Asian Journal of Andrology — Sun, 29 Dec 2013 09:40:03 +0100

Authors: Ping P, Gu BH, Li P, Huang YR, Li Z Abstract Testicular cancer (TC) is the most curable type of cancer, with a survival rate of more than 95%. Oncologists are faced with the challenge that gonadotoxic cancer treatments can compromise future fertility, either temporarily or permanently. Our aim was to investigate the long-term effects of TC treatments on male fertility and on the offspring of patients who had received these treatments. Between January 1996 and December 2010, 125 eligible patients, ranging from 18 to 54 years (median age 36.3 ± 15.7), with unilateral TC underwent surgery, chemotherapy or radiotherapy at our center. Some of these patients had their semen samples cryopreserved in the Shanghai Human Sperm Bank. The clinical data were evaluated, and questionnai...

Similar causes of various reproductive disorders in early life.

Asian Journal of Andrology — Sun, 29 Dec 2013 09:40:03 +0100

Authors: Svechnikov K, Stukenborg JB, Savchuck I, Söder O Abstract During the past few decades, scientific evidence has been accumulated concerning the possible adverse effects of the exposure to environmental chemicals on the well-being of wildlife and human populations. One large and growing group of such compounds of anthropogenic or natural origin is referred to as endocrine-disrupting chemicals (EDCs), due to their deleterious action on the endocrine system. This concern was first focused on the control of reproductive function particularly in males, but has later been expanded to include all possible endocrine functions. The present review describes the underlying physiology behind the cascade of developmental events that occur during sexual differentiation of males and the ...

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Maternal cigarette smoking during pregnancy and reproductive health in children: a review of epidemiological studies.

Asian Journal of Andrology — Sun, 29 Dec 2013 09:40:03 +0100

In conclusion, prenatal exposure to cigarette smoking may cause some long-term adverse effects on the reproductive health. PMID: 24369132 [PubMed - in process] (Source: Asian Journal of Andrology)

Retrospective cohort study of a microelectronics and business machine facility

American Journal of Industrial Medicine — Thu, 26 Dec 2013 04:00:24 +0100

ConclusionsFew significant exposure–outcome relations were observed, but risks from occupational exposures cannot be ruled out due to data limitations and the relative youth of the cohort. Am. J. Ind. Med. © 2013 Wiley Periodicals, Inc. (Source: American Journal of Industrial Medicine)

Testicular cancer incidence to rise by 25% by 2025 in Europe? Model-based predictions in 40 countries using population-based registry data

European Journal of Cancer — Thu, 26 Dec 2013 00:00:00 +0100

Abstract: Background: Testicular cancer mainly affects White Caucasian populations, accounts for 1% of all male cancers, and is frequently the most common malignancy among young adult men. In light of the escalating rates of testicular cancer incidence in Europe, and in support of future planning to ensure optimal care of patients with what can be a curable disease, we predict the future burden in 40 European countries around 2025.Methods: Current observed trends were extrapolated with the NORDPRED model to estimate the future burden of testicular cancer in the context of changes in risk versus changes in demographics.Findings: Despite substantial heterogeneity in the rates, the vast majority of European countries will see an increasing burden over the next two decades. We estimate there w...

Choriogonadotropin positive seminoma—a clinicopathological and molecular genetic study of 15 cases

Annals of Diagnostic Pathology — Thu, 26 Dec 2013 00:00:00 +0100

In this study, we present 15 such cases. 168 CSs were retrieved from the Plzen Tumor registry. Cases of mixed germ cell tumors (with CS) and CSs with typical STC were excluded. Cases with completely embedded tumor mass were selected for further study and immunohistochemically examined with anti-hCG. Positive cases were further analyzed by reverse transcriptase polymerase chain reaction. Two groups of hCG-positive CSs were identified. Group 1 comprised 10 patients with a mean patient age of 37.7 years and mean tumor size of 4.96 cm. Eight cases were pT1 (TMN 2009) and 2 cases pT3a. Blood levels of hCG were elevated in 6 of the 10 patients preoperatively. In 2 patients the blood level of hCG was not tested. Mean follow-up period was 6.1 years. No metastatic behavior was noted. All tumors wer...

Idiopathic granulomatous orchitis: morphology and evaluation of its relationship to IgG4 related disease

Human Pathology — Mon, 23 Dec 2013 00:00:00 +0100

Summary: Idiopathic granulomatous orchitis (IGO) is rare, thought to result from an autoimmune reaction to spermatogenic elements. Its relationship to IgG4-related disease (IgG4-RD) has not been evaluated. Sixteen orchiectomy specimens (1984-2012) with a prominent intratubular granulomatous reaction were reviewed: IGO (n = 6); intratubular germ cell neoplasia unclassified (IGCNU) with a granulomatous reaction and associated seminoma (GS, n = 6); and unclassified intratubular granulomatous orchitis not fitting into a specific entity (UGO, n = 4). Men with IGO were 32 to 86 years old, presenting with a mass suspicious for malignancy. Only one patient had a history of an inflammatory disease. Clinical follow-up was available for 2 patients with IGO, and both had no evidence of systemic IgG4-R...

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Lifetime growth and risk of testicular cancer

International Journal of Cancer — Sat, 21 Dec 2013 04:47:10 +0100

Abstract Adult height is associated with testicular cancer risk. We studied to what extent this association is explained by parental height, childhood height and age at puberty. We conducted a case‐control study on germ‐cell testicular cancer patients diagnosed in 1997‐2008 and resident in the Province of Turin. Information was collected using mailed questionnaires in 2008‐2011. Specifically, we asked for adult height (in cm), height at age 9 and 13 (compared to peers), and age at puberty (compared to peers). We also asked for paternal and maternal height (in cm), as indicators of genetic components of adult height. The analysis included 255 cases and 459 controls. Odds ratios (OR) of testicular cancer were estimated for the different anthropometric variables. Adult height was asso...

Klinefelter syndrome 47,XXY

About.com Breast Cancer — Thu, 19 Dec 2013 05:00:00 +0100

Klinefelter syndrome is a rare genetic condition in which a man has an extra X chromosome. (Males usually have one X and one Y chromosome.) Some of the other conditions associated with Klinefelter are hypothyroidism, infertility, testicular cancer, and an increased risk for male breast cancer. (Source: About.com Breast Cancer)

Late gastrointestinal morbidity in patients with stage I-II testicular seminoma treated with radiotherapy.

Urologic Oncology — Wed, 11 Dec 2013 05:00:00 +0100

CONCLUSIONS: In this patient population, late GI morbidity was relatively uncommon, but clinically significant. Refinements of treatment strategies may reduce this risk. PMID: 24332645 [PubMed - as supplied by publisher] (Source: Urologic Oncology)

Sequential bilateral testicular tumours presenting with intervals of 20 years and more

BMC Urology - Latest articles — Mon, 09 Dec 2013 05:00:00 +0100

Conclusion: Apart from increased risks of cardiovascular diseases and non-testicular malignancies, patients with GCT face the specific probability of a second GCT in the long run. This risk persists life-long and is not eliminated by chemotherapy. Contralateral testicular biopsy can identify patients at risk by revealing precursor cells of GCT though false-negative biopsies may occur sporadically. However, in view of the multi-facetted late hazards of GCT patients, this minor surgical procedure might somewhat simplify the long-time care of these patients. (Source: BMC Urology - Latest articles)

Sequential bilateral testicular tumours presenting with intervals of 20 years and more

BMC Urology - Latest articles — Mon, 09 Dec 2013 05:00:00 +0100

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Osteonecrosis requiring total joint arthroplasty is a rare sequel in children and young adults treated for solid tumors.

Acta Oncologica — Mon, 09 Dec 2013 05:00:00 +0100

Conclusion. Severe ON requiring TJA is a rare sequel in children and young adults treated for solid tumors. It was observed most commonly in patients treated for renal, breast, or testicular cancer. PMID: 24313392 [PubMed - as supplied by publisher] (Source: Acta Oncologica)

Treatment of testicular cancer.

Bulletin du Cancer — Fri, 06 Dec 2013 05:00:00 +0100

Authors: Droz JP, Boyle H, Culine S, Fizazi K, Fléchon A, Massard C Abstract Germ-cell tumours (GCTs) are the most common type of cancer in young men. Since the late 1970s, disseminated GCT have been a paradigm for curable metastatic cancer and metastatic GCTs are highly curable with cisplatin-based chemotherapy followed by surgical resection of residual masses. Patients' prognosis is currently assessed using the International Germ-Cell Consensus Classification (IGCCC) and used to adapt the burden of chemotherapy. Approximately 20% of patients still do not achieve cure after first-line cisplatin-based chemotherapy, and need salvage chemotherapy (high dose or standard dose chemotherapy). Clinical stage I testicular cancer is the most common presentation and different strategies are...

Lower gastrointestinal bleeding as a result of fistula between the iliac artery and sigmoid colon in patient with advanced testicular cancer

International Braz J Urol — Tue, 03 Dec 2013 21:32:05 +0100

We report a case of a patient with previous surgery for seminoma of cryptorchidic testicle, with massive lower gastrointestinal bleeding. We performed the diagnosis and surgical treatment of the fistula between left external iliac artery and sigmoid colon. The patient was successfully treated by external iliac artery ligation and left colectomy. (Source: International Braz J Urol)

Therapy-Related Myelodysplasia and Acute Myeloid Leukemia

Seminars in Oncology — Sun, 01 Dec 2013 05:00:00 +0100

Therapy-related leukemia (myelodysplasia and acute myeloid leukemia—t-MDS/AML) is a well-known complication of conventional chemoradiotherapy used to treat a variety of primary malignancies including Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL), acute lymphoblastic leukemia (ALL), sarcoma, and ovarian and testicular cancers. The median time to development of t-MDS/AML is 3–5 years, with the risk decreasing markedly after the first decade. t-MDS/AML is the major cause of non-relapse mortality after autologous hematopoietic cell transplantation (HCT) for HL or NHL. The magnitude of risk of t-MDS/AML is higher, and the latency is shorter after HCT, compared to conventional therapy. Two types of t-MDS/AML are recognized depending on the causative therapeutic exposure: an alkylating...

Comparison of Address-based Sampling and Random-digit Dialing Methods for Recruiting Young Men as Controls in a Case-Control Study of Testicular Cancer Susceptibility

American Journal of Epidemiology — Thu, 28 Nov 2013 05:00:00 +0100

In this study, we compared landline RDD with alternative methods of control recruitment, including RDD using cell-phone numbers and address-based sampling (ABS), to recruit primarily white men aged 18–55 years into a study of testicular cancer susceptibility conducted in the Philadelphia, Pennsylvania, metropolitan area between 2009 and 2012. With few exceptions, eligible and enrolled controls recruited by means of RDD and ABS were similar with regard to characteristics for which data were collected on the screening survey. While we find ABS to be a comparably effective method of recruiting young males compared with landline RDD, we acknowledge the potential impact that selection bias may have had on our results because of poor overall response rates, which ranged from 11.4% for land...

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Oncological Outcomes of Metastatic Testicular Cancers under Centralized Management through Regional Medical Network

Japanese Journal of Clinical Oncology — Wed, 27 Nov 2013 05:00:00 +0100

Conclusions Induction chemotherapy with high relative dose intensity, post-chemotherapy surgery and salvage chemotherapy was accomplished efficiently through centralization of management. Oncological outcomes were excellent, especially in patients with poor-prognosis disease, whose 5-year OS reached 84%. (Source: Japanese Journal of Clinical Oncology)

Second cancer risk and mortality in men treated with radiotherapy for stage I seminoma

British Journal of Cancer AOP — Thu, 21 Nov 2013 05:00:00 +0100

Authors: A Horwich, S D Fossa, R Huddart, D P Dearnaley, S Stenning, M Aresu, J M Bliss & E Hall (Source: British Journal of Cancer AOP)

[Diagnosis and treatment of nonseminomatous germ cell tumors.]

Der Urologe. Ausg. A — Wed, 20 Nov 2013 05:00:00 +0100

Authors: Krege S Abstract Testicular cancer currently shows excellent rates of curing and even in advanced stages of disease about 70% can be achieved. This was possible due to continuously carrying out studies. To reduce long-term toxicity the focus is now put on reduction of treatment. In nonseminomatous germ cell cancer this is discussed especially for stage I disease where different therapeutic strategies can be offered. Concerning advanced disease the aim is a further improvement of treatment results. Polychemotherapy and surgical procedures are equally important in this scenario. Concerning residual tumor resection it should always be considered that the procedure can be extended by adjuvant surgery, e.g. cava resection. Therefore, those resections should only be performed at...

The management of retroperitoneal lymphadenopathy in spermatocytic seminoma of the testicle

Clinical Imaging — Wed, 20 Nov 2013 00:00:00 +0100

We present a 49-year-old man with spermatocytic seminoma and retroperitoneal and mesenteric lymphadenopathy who was found to have concurrent low-grade lymphoma. (Source: Clinical Imaging)

Use of Contrast‐Enhanced Ultrasonography in Chronic Pathologic Canine Testes

Reproduction in Domestic Animals — Mon, 18 Nov 2013 05:00:00 +0100

Contents Contrast‐enhanced ultrasound with sulphur hexafluoride microbubbles was performed in seven healthy dogs without a history of reproductive pathology and with histologically confirmed normal testes and in 42 dogs with chronic scrotal anomalies. All dogs underwent orchiectomy and histological examination. Enhancement patterns and perfusion parameters (peak intensity and regional blood flow) of testes of healthy dogs and testes with chronic lesions were compared. Fourteen non‐pathologic and 60 pathologic testes were considered. Forty testes were neoplastic (24 interstitial cell tumours, 9 seminomas, 7 Sertoli cell tumours), 20 were non‐neoplastic (16 testicular degenerations, 2 chronic orchitis, 1 testicular atrophy, 1 interstitial cell hyperplasia). In healthy dogs, the contras...

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Phenotypic characterisation of immune cell infiltrates in testicular germ cell neoplasia

Journal of Reproductive Immunology — Mon, 18 Nov 2013 05:00:00 +0100

This study showed a phenotypically comparable composition of infiltrating immune cells independently of the presence of neoplasia, suggesting the absence of active immune surveillance in testicular germ cell cancer. (Source: Journal of Reproductive Immunology)

Spermatocytic seminoma: a 21 years' retrospective study in a tertiary care hospital in Pakistan.

International Journal of Clinical and Experimental Pathology — Sat, 16 Nov 2013 19:25:02 +0100

CONCLUSION: CD 117 is of limited utility in differentiating the spermatocytic seminoma from classic seminoma as it is expressed in significant number of spermatocytic seminomas. However, different histological features, PAS special stain and PLAP immunostain are significantly helpful in distinguishing these two entities. PMID: 24228096 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)

Building the mammalian testis: origins, differentiation, and assembly of the component cell populations [Reviews]

Genes and Development — Fri, 15 Nov 2013 05:00:00 +0100

Development of testes in the mammalian embryo requires the formation and assembly of several cell types that allow these organs to achieve their roles in male reproduction and endocrine regulation. Testis development is unusual in that several cell types such as Sertoli, Leydig, and spermatogonial cells arise from bipotential precursors present in the precursor tissue, the genital ridge. These cell types do not differentiate independently but depend on signals from Sertoli cells that differentiate under the influence of transcription factors SRY and SOX9. While these steps are becoming better understood, the origins and roles of many testicular cell types and structures—including peritubular myoid cells, the tunica albuginea, the arterial and venous blood vasculature, lymphatic vesse...

Chemotherapy‐induced peripheral neurotoxicity: A critical analysis

CA: A Cancer Journal for Clinicians — Mon, 11 Nov 2013 05:00:00 +0100

With a 3‐fold increase in the number of cancer survivors noted since the 1970s, there are now over 28 million cancer survivors worldwide. Accordingly, there is a heightened awareness of long‐term toxicities and the impact on quality of life following treatment in cancer survivors. This review will address the increasing importance and challenge of chemotherapy‐induced neurotoxicity, with a focus on neuropathy associated with the treatment of breast cancer, colorectal cancer, testicular cancer, and hematological cancers. An overview of the diagnosis, symptomatology, and pathophysiology of chemotherapy‐induced peripheral neuropathy will be provided, with a critical analysis of assessment strategies, neuroprotective approaches, and potential treatments. The review will concentrate on ...

Venous thromboembolic events in germ cell cancer patients undergoing platinum-based chemotherapy.

Onkologie — Mon, 11 Nov 2013 00:00:02 +0100

Conclusions: The incidence of VTEEs in GCT patients was 11%, but in the majority of patients, the VTEEs occurred before the initiation of platinum-based chemotherapy. Supraclavicular lymph node metastases and use of a CVC are risk factors for VTEEs during chemotherapy. © 2013 S. Karger GmbH, Freiburg. PMID: 24192771 [PubMed - in process] (Source: Onkologie)

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EORTC study: Prognostic value of baseline recorded health-related quality of life for survival for eleven types of cancer

Health News from Medical News Today — Fri, 08 Nov 2013 09:00:00 +0100

Results of an EORTC study published in Cancer point out the prognostic value of baseline recorded health-related quality of life for survival for eleven types of cancer: brain, breast, colorectal, esophageal, head and neck, lung, melanoma, ovarian, pancreatic, prostate, and testicular cancer. For each cancer site, at least one health-related quality of life parameter provided additional prognostic information over and above the clinical and sociodemographic variables. Dr... (Source: Health News from Medical News Today)

Comment on ‘Chemotherapy for testicular cancer induces acute alterations in diastolic heart function’

British Journal of Cancer AOP — Thu, 07 Nov 2013 05:00:00 +0100

Comment on ‘Chemotherapy for testicular cancer induces acute alterations in diastolic heart function’ British Journal of Cancer advance online publication, November 7 2013. doi:10.1038/bjc.2013.703 Author: K-P Dieckmann (Source: British Journal of Cancer AOP)

Reply: Comment on ‘Chemotherapy for testicular cancer induces acute alterations in diastolic heart function’

British Journal of Cancer AOP — Thu, 07 Nov 2013 05:00:00 +0100

Reply: Comment on ‘Chemotherapy for testicular cancer induces acute alterations in diastolic heart function’ British Journal of Cancer advance online publication, November 7 2013. doi:10.1038/bjc.2013.704 Authors: L D van Schinkel, P M Willemse, R W van der Meer, J Burggraaf, S G C van Elderen, J W A Smit, A de Roos, S Osanto & H J Lamb (Source: British Journal of Cancer AOP)

October eFactor

Environmental Factor - NIEHS Newsletter — Wed, 06 Nov 2013 15:15:16 +0100

Council has a busy two days Capitol Hill events put spotlight on environmental connections to cancer NIEHS collaborates with World Health Organization to address global environmental health issues NIEHS scientists, grantees participate in environment and health conference Balbus briefs Congress on climate change and public health Miller delivers keynote at international conference on occupational health Bucher keynotes at meeting of hazardous waste specialists Advisors learn about the reinvention of ICCVAM Rutgers holds high school summer program Public health group announces launch of Canadian Environmental Health Atlas PEPH webinar highlights tribal efforts to address environmental justice and public health NIEHS hosts local middle school students SRP grantees gather in Baton...

Prognostic value of baseline HRQOL for survival for 11 types of cancer pointed out by EORTC study

EurekAlert! - Medicine and Health — Wed, 06 Nov 2013 05:00:00 +0100

(European Organisation for Research and Treatment of Cancer) Results of an EORTC study published in Cancer point out the prognostic value of baseline recorded health-related quality of life for survival for eleven types of cancer: brain, breast, colorectal, esophageal, head and neck, lung, melanoma, ovarian, pancreatic, prostate, and testicular cancer. For each cancer site, at least one health-related quality of life parameter provided additional prognostic information over and above the clinical and sociodemographic variables. (Source: EurekAlert! - Medicine and Health)

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Teaching NeuroImages: Ma2 encephalitis presenting as acute panhypopituitarism in a young man

Neurology — Mon, 04 Nov 2013 05:00:00 +0100

A 21-year-old man presented with headache, hypotonia, hypothermia, and somnolence, deteriorating to a Glasgow Coma Scale score of 3 within days. Hormonal testing revealed panhypopituitarism. His cerebral MRI showed a gadolinium-enhancing lesion in the pituitary gland with adjacent changes to the hypothalamus, midbrain, and basal ganglia (figures 1 and 2). Therapy with prednisolone resulted in rapid improvement. Ma2 antibodies were found in the patient’s serum and CSF. FDG-PET demonstrated a tumor mass in the superior mediastinum and histology revealed a mediastinal seminoma. Ma2 antibody–mediated paraneoplastic disease has to be considered as a rare differential diagnosis in patients presenting with acute panhypopituitarism.1 (Source: Neurology)

Testicular‐sparing surgery for bilateral or monorchide testicular tumors: a multicenter study of long term oncological and functional results

BJU International — Fri, 01 Nov 2013 04:00:00 +0100

ConclusionsSparing surgery for bilateral testicular tumor is safe and effective in selected patients, and should be considered to avoid definitive androgen therapy. Adjuvant radiotherapy remains poorly described leading to adjuvant treatment heterogeneity. (Source: BJU International)

Assessment and Management of Renal Impairment in Chemotherapy for Urogenital Cancer

Japanese Journal of Clinical Oncology — Fri, 01 Nov 2013 04:00:00 +0100

The method of diagnosing chronic kidney disease by simple estimated glomerular filtration rate equations has demonstrated a high prevalence of chronic kidney disease among the genitourinary cancer patients. Approximately 30–50% of urothelial cancer patients have Grade 3 chronic kidney disease before chemotherapy, and the rate increases to around 80% in upper urinary tract cancer patients who have undergone radical surgery. Several gold-standard treatments, including cisplatin for urothelial/testicular tumors and anti-vascular endothelial growth factor therapy for kidney cancers, are known to be associated with the development of renal impairment. However, which renal function assessments are best to select a chemotherapy regimen remain unknown. Most testicular tumor patients are cure...

[Pharmacological therapy of urogenital cancer : Rational routine diagnostic imaging].

Der Urologe. Ausg. A — Fri, 01 Nov 2013 04:00:00 +0100

CONCLUSIONS: Imaging studies to assess therapeutic response to systemic treatment in metastatic cancers of the urogenital tract must be chosen depending on the treatment regime, primary organ, and potential consequences of the findings. Routine imaging studies without specific clinical or therapeutic relevance are not justified. PMID: 24197084 [PubMed - in process] (Source: Der Urologe. Ausg. A)

Surgery for treatment of metastatic testicular cancer

ANZ Journal of Surgery — Thu, 31 Oct 2013 04:00:00 +0100

(Source: ANZ Journal of Surgery)

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Chemotherapy-induced peripheral neurotoxicity: A critical analysis.

Clinical Genitourinary Cancer — Thu, 31 Oct 2013 04:00:00 +0100

Authors: Park SB, Goldstein D, Krishnan AV, Lin CS, Friedlander ML, Cassidy J, Koltzenburg M, Kiernan MC Abstract With a 3-fold increase in the number of cancer survivors noted since the 1970s, there are now over 28 million cancer survivors worldwide. Accordingly, there is a heightened awareness of long-term toxicities and the impact on quality of life following treatment in cancer survivors. This review will address the increasing importance and challenge of chemotherapy-induced neurotoxicity, with a focus on neuropathy associated with the treatment of breast cancer, colorectal cancer, testicular cancer, and hematological cancers. An overview of the diagnosis, symptomatology, and pathophysiology of chemotherapy-induced peripheral neuropathy will be provided, with a critical analys...

Chemotherapy‐induced peripheral neurotoxicity: A critical analysis

CA: A Cancer Journal for Clinicians — Thu, 31 Oct 2013 04:00:00 +0100

Integrating multiple oestrogen receptor alpha ChIP studies: overlap with disease susceptibility regions, DNase I hypersensitivity peaks and gene expression

BMC Medical Genomics — Wed, 30 Oct 2013 04:00:00 +0100

Conclusions: Our study suggests that integration of multiple ChIP datasets can highlight binding sites likely to be of particular biological importance and can provide important insights into understanding human health and disease. However, it also highlights the high number of likely false positive binding sites in ChIP datasets drawn from cell lines and illustrates the importance of considering multiple independent experiments together. (Source: BMC Medical Genomics)

DuPont sued multiple times as court-backed science panel finds chemical C8 used in Teflon is linked to cancer

NaturalNews.com — Tue, 29 Oct 2013 06:00:00 +0100

Back in April 2013, DuPont was sued in a wrongful death case when a court-appointed science panel linked DuPont's C8 (perfluorooctanoic acid) to kidney cancer, thyroid disease and testicular cancer, to name a few adverse effects. 2001 lawsuit advances forwardDupont's... (Source: NaturalNews.com)

Ifosfamide related encephalopathy: The need for a timely EEG evaluation

Journal of the Neurological Sciences — Mon, 28 Oct 2013 04:00:00 +0100

Conclusions: Severity of ifosfamide related encephalopathy correlates with EEG changes. We suggest a timely EEG evaluation for patients receiving ifosfamide who develop features of encephalopathy. (Source: Journal of the Neurological Sciences)

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Microdissection Testicular Sperm Extraction and Salvage Hormonal Treatment in Patients With Postchemotherapy Azoospermia

Urology — Thu, 24 Oct 2013 04:00:00 +0100

Conclusion: Micro-TESE–intracytoplasmic sperm injection is an effective fertility treatment for patients with PCA. Furthermore, patients who could not achieve successful sperm retrieval by micro-TESE might obtain improved outcomes with hormonal therapy, indicating that these treatments might provide the patients with PCA with the opportunity to retrieve sperm and father a child. (Source: Urology)

FELD better, not thinking of metastases only when liver lesions appear after bleomycin-based treatment for non-seminoma testis from metastases

BioMed Central — Tue, 22 Oct 2013 04:00:00 +0100

Conclusion: As follow up may consist of CT scanning in germ-line tumor patients, transient eosinophilic liver lesions reported during regressive bleomycin-induced pneumonitis should not be presumed automatically as metastatic tumor relapse and require further sequential imaging and pathological examination. (Source: BioMed Central)

Sperm cryopreservation for Chinese male cancer patients: a 17-year retrospective analysis in an assisted reproductive unit in Hong Kong.

Hong Kong Med J — Mon, 21 Oct 2013 04:00:00 +0100

CONCLUSION. Sperm cryopreservation is a simple and effective way of preserving the fertility potential of male patients undergoing gonadotoxic treatment. This procedure is underutilised and deserves increased awareness by all possible means. PMID: 24141859 [PubMed - as supplied by publisher] (Source: Hong Kong Med J)

Tanning Gene Linked to Increased Risk of Testicular Cancer

MedlinePlus Health News — Sat, 19 Oct 2013 05:06:49 +0100

Source: National Institute of Environmental Health Sciences - Related MedlinePlus Page: Testicular Cancer (Source: MedlinePlus Health News)

Tanning gene linked to increased risk of testicular cancer, according to NIH scientists

National Institutes of Health (NIH) News Releases — Fri, 18 Oct 2013 13:29:00 +0100

Nearly 80 percent of white men carry a variant of the gene. (Source: National Institutes of Health (NIH) News Releases)

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Tanning Gene Linked to Testicular Cancer for White Males

PharmaManufacturing.com — Fri, 18 Oct 2013 06:09:06 +0100

Nearly 80 percent of white men carry a variant form of this gene, which increased risk of testicular cancer up to threefold in the study (Source: PharmaManufacturing.com)

Tanning gene linked to increased risk of testicular cancer, according to NIH scientists

EurekAlert! - Medicine and Health — Fri, 18 Oct 2013 04:00:00 +0100

(NIH/National Institute of Environmental Health Sciences) A gene important in skin tanning has been linked to higher risk for testicular cancer in white men, according to a study led by scientists from the US National Institutes of Health and the University of Oxford in England. Nearly 80 percent of white men carry a variant form of this gene, which increased risk of testicular cancer up to threefold in the study. (Source: EurekAlert! - Medicine and Health)

Tanning Gene Linked to Increased Risk of Testicular Cancer, According to NIH Scientists

NIEHS - National Institute of Environmental Health Sciences - News — Fri, 18 Oct 2013 04:00:00 +0100

A gene important in skin tanning has been linked to higher risk for testicular cancer in white men, according to a study led by scientists from the U.S. National Institutes of Health and the University of Oxford in England. Nearly 80 percent of white men carry a variant form of this gene, which increased risk of testicular cancer up to threefold in the study.The research appeared online October 10... (Source: NIEHS - National Institute of Environmental Health Sciences - News)

Solid Tumors After Chemotherapy or Surgery for Testicular Nonseminoma: A Population-Based Study [Urologic Oncology]

Journal of Clinical Oncology — Fri, 18 Oct 2013 04:00:00 +0100

Conclusion To our knowledge, this is the first large population-based series reporting significantly increased risks of solid cancers among patients with testicular nonseminoma treated in the modern era of cisplatin-based chemotherapy. Subsequent analytic studies should focus on the evaluation of dose-response relationships, types of solid cancers, latency patterns, and interactions with other possible factors, including genetic susceptibility. (Source: Journal of Clinical Oncology)

Tanning Gene Linked to Increased Risk of Testicular Cancer, According to NIH Scientists

NIEHS - National Institute of Environmental Health Sciences - News — Fri, 18 Oct 2013 04:00:00 +0100

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Cancer: Two-faced cancer gene

Nature — Wed, 16 Oct 2013 04:00:00 +0100

Nature 502, 7471 (2013). doi:10.1038/502275b A genetic variant that greatly boosts the risk of testicular cancer may protect light-skinned individuals from skin cancer by helping them to tan.A team led by Douglas Bell at the US National Institutes of Health in Bethesda, Maryland, and Gareth Bond at the University (Source: Nature)

[Update on first-line and relapse chemotherapy for testicular cancer.]

Der Urologe. Ausg. A — Wed, 16 Oct 2013 04:00:00 +0100

Authors: Lorch A, Albers P Abstract Germ-cell cancer (GCC) is still the most common cancer diagnosis in men between the ages of 20 and 45 years with an increasing incidence. Due to effective and standardized algorithms that have been developed to stratify patients into different risk groups, remarkable progress has been made in the medical treatment of testicular cancer with an overall cure rate of 88%. The application of surgery, radiotherapy and chemotherapy, the choice of chemotherapy agents as well as treatment duration is defined in international consensus guidelines. The guidelines are based on histology, tumor stages and presence or absence of already known and well-established risk factors. These stringent parameters guarantee the optimal curative treatment options for eac...

[Cryptorchidism: Guidelines for surgical management.]

Archives de Pediatrie — Tue, 15 Oct 2013 04:00:00 +0100

Authors: Sapin E Abstract Cryptorchidism is one of the commonest congenital anomalies in the male genitalia, affecting 3 to 5% of male full-term neonates. It is a known cause of infertility associated with a greater risk of development of germ cell tumor. The benefits of early orchidopexy include psychological affects, prevention of testicular degeneration and decrease in the risk of testicular cancer. Laparoscopy is the best way to diagnose and manage intra-abdominal testes. PMID: 24139390 [PubMed - as supplied by publisher] (Source: Archives de Pediatrie)

Gene variation that offers skin protection from sun damage may increase risk for testicular cancer

Health News from Medical News Today — Mon, 14 Oct 2013 07:00:00 +0100

A Ludwig Cancer Research study published in Cell identifies a common mutation that dramatically increases the risk for testicular cancer - and describes a likely molecular mechanism by which it exerts that effect. The researchers also suggest why, despite its potential lethality, the genetic variation has been favored by natural selection to become common in light-skinned people. It appears this mutation might aid the tanning of Caucasian skin in response to sunlight, protecting it from UV radiation, which can burn and cause cancer... (Source: Health News from Medical News Today)

Genetic Variation Fuels Testicular Cancer

Medical Headlines From Ivanhoe.com — Mon, 14 Oct 2013 05:00:00 +0100

(Ivanhoe Newswire) –New research identifies a common mutation that dramatically increases the risk for testicular cancer and describes a likely molecular mechanism by which it exerts that effect. Researchers also explain why the genetic variation is more common in light-skinned people. (Source: Medical Headlines From Ivanhoe.com)

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A Case Report of Primary Mediastinal Seminoma Diagnosised as Pulmonary Fibrosis

Chinese Journal of Lung Cancer — Sun, 13 Oct 2013 00:19:39 +0100

DOI: 10.3779/j.issn.1009-3419.2013.10.12 (Source: Chinese Journal of Lung Cancer)

A Trade-off Between Skin Protection and Testicular Cancer Risk

NPR Health and Science — Fri, 11 Oct 2013 16:00:00 +0100

A genetic variation that protects skin against sun damage may also increase the risk of testicular cancer, at least in mice. Researcher Gareth Bond discusses why this relationship may have evolved and how the findings could help to create personalized cancer treatments for humans.» E-Mail This » Add to Del.icio.us (Source: NPR Health and Science)

Genetic variant that increases testicular cancer risk in caucasians evolved to protect light skin

EurekAlert! - Social and Behavioral Science — Thu, 10 Oct 2013 04:00:00 +0100

(Cell Press) One of the most important proteins implicated in cancer is p53. Researchers have identified a DNA sequence variation in a p53-binding site that is more prevalent in Caucasians than in Africans and is associated with a very large risk of testicular cancer but may protect light-skinned individuals against harmful ultraviolet rays. The study offers insights into the evolution of DNA sequence variations in p53-binding sites, and it could lead to improvements in personalized treatment strategies. (Source: EurekAlert! - Social and Behavioral Science)

18F-FDG-PET/CT in a patient with suspected recurrence of germ cell tumor

Journal of Cancer Research and Therapeutics — Tue, 08 Oct 2013 04:00:00 +0100

Daniele Penna, Vincenzo Arena, Ettore PelosiJournal of Cancer Research and Therapeutics 2013 9(3):520-522At present, the available clinical practice guidelines for the management of patients with germ cell tumor (GCT) assign to Positron Emission Tomography (PET) scan a role in the evaluation of the residual mass at the end of the treatment of advanced seminoma, while a possible role of this tool in the strategy of follow-up has not been defined yet. We are presenting a case of a patient treated for a GCT with an increase of the marker levels during the follow-up where a PET/CT with 18F-FDG was the only noninvasive examination able to correctly identify the site of disease recurrence. This case shows how this tool could have a role, in addition to morphological examinations, in the manageme...

Null Association Between Histology of First and Second Primary Malignancies in Men With Bilateral Testicular Germ Cell Tumors

American Journal of Epidemiology — Tue, 08 Oct 2013 04:00:00 +0100

Testicular germ cell tumors (TGCTs), the most common neoplasms of young men, are categorized histologically as either seminomas or nonseminomas/mixed germ cell tumors. These subtypes differ by age at diagnosis and clinical course, but little is known about etiological distinctions. To test the hypothesis that histological subtypes have distinct sets of unrecognized etiological factors, we used a recently described approach, estimating the association between histological types of first and second tumors of men with 2 primary TGCTs. The study population of 488 men each with 2 primary TGCTs was ascertained through population-based cancer registries in the United States between 1972 and 2006. Univariate logistic regression analysis revealed that the histology of second primary TGCTs was assoc...

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Robot‐assisted laparoscopic retroperitoneal lymph node dissection for left clinical stage I non‐seminomatous germ cell testicular cancer: Focus on port placement and surgical technique

International Journal of Urology — Mon, 30 Sep 2013 04:00:00 +0100

Abstract The aim of our report was to describe the feasibility of robotic retroperitoneal lymph node dissection in the contemporary era. We suggest the linear port location and 90° robotic docking as the main key to minimizing instrument clashing and improving the range of surgical accessibility. (Source: International Journal of Urology)

Fibroblast growth factor receptors, developmental corruption and malignant disease

Carcinogenesis — Mon, 30 Sep 2013 04:00:00 +0100

Fibroblast growth factors (FGF) are a family of ligands that bind to four different types of cell surface receptor entitled, FGFR1, FGFR2, FGFR3 and FGFR4. These receptors differ in their ligand binding affinity and tissue distribution. The prototypical receptor structure is that of an extracellular region comprising three immunoglobulin (Ig)-like domains, a hydrophobic transmembrane segment and a split intracellular tyrosine kinase domain. Alternative gene splicing affecting the extracellular third Ig loop also creates different receptor isoforms entitled FGFRIIIb and FGFRIIIc. Somatic fibroblast growth factor receptor (FGFR) mutations are implicated in different types of cancer and germline FGFR mutations occur in developmental syndromes particularly those in which craniosynostosis is a ...

Active Surveillance Is the Preferred Approach to Clinical Stage I Testicular Cancer [COMMENTS AND CONTROVERSIES]

Journal of Clinical Oncology — Fri, 27 Sep 2013 04:00:00 +0100

(Source: Journal of Clinical Oncology)

Cancer mortality in Europe, 2005-2009, and an overview of trends since 1980

Annals of Oncology — Thu, 26 Sep 2013 04:00:00 +0100

Conclusions With the major exceptions of female lung cancer and pancreatic cancer in both sexes, in the last quinquennium, cancer mortality has moderately but steadily declined across Europe. However, substantial differences across countries persist, requiring targeted interventions on risk factor control, early diagnosis, and improved management and pharmacological treatment for selected cancer sites. (Source: Annals of Oncology)

Critical role of CCDC6 in the neoplastic growth of testicular germ cell tumors

BMC Cancer — Tue, 24 Sep 2013 04:00:00 +0100

Conclusions: Therefore, our results suggest that the loss of CCDC6 could aid the spermatogonial cells to be part of a pro-survival pathway that helps to evade the toxic effects of endogenous oxidants and contributes to testicular neoplastic growth. (Source: BMC Cancer)

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Detection of persistent organic pollutants binding modes with androgen receptor ligand binding domain by docking and molecular dynamics

BMC Structural Biology - Latest articles — Sun, 22 Sep 2013 04:00:00 +0100

Conclusions: POPs disrupt the function of AR through binding to three possible biding sites on AR/LBD. One of them shares the same binding site of natural ligand of AR. Another one is on AF2 region. The third one is in a cleft near N-terminal of the receptor. Significantly, values of binding free energy of POPs with AR/LBD are comparable to that of natural ligand androgen DHT. (Source: BMC Structural Biology - Latest articles)

Seminoma with Bronchial Involvement and Superior Vena Cava Syndrome: A Rare Combination.

Archivos de Bronconeumologia — Sat, 21 Sep 2013 04:00:00 +0100

We describe the case of a 45-year-old male who was admitted with clinical signs of superior vena cava syndrome (SVCS). Physical examination showed collar of Stokes and extensive collateral circulation in the neck and anterosuperior thoracic region, as well as a large testicular mass. Fibrobronchoscopy revealed an endobronchial tumour, histopathologically diagnosed as seminoma, with the same characteristics as the testicular biopsy. Treatment was initiated with surgery, chemotherapy and radiotherapy, resulting in a major clinical improvement. We indicate the importance of considering SVCS as an entity related with less common neoplasms such as germ cell tumours. PMID: 24064342 [PubMed - as supplied by publisher] (Source: Archivos de Bronconeumologia)

A novel cell-processing method 'AgarCytos' in conjunction with OCT3/4 and PLAP to detect intratubular germ cell neoplasia in non-obstructive azoospermia using remnants of testicular sperm extraction specimens

Human Reproduction — Thu, 19 Sep 2013 04:00:00 +0100

This study was (partially) funded by Merck Serono (the Netherlands). There are no conflicting interests to disclose. TRIAL REGISTRATION NUMBER N/A. (Source: Human Reproduction)

Diagnosis of testicular cancer with a urine pregnancy test in an austere military medical environment

The American Journal of Emergency Medicine — Thu, 19 Sep 2013 04:00:00 +0100

Testicular cancer is an uncommon cancer in the United States, responsible for approximately 8000 new cases per year . Although diagnosis of testicular cancer in the United States is fairly straightforward in a hospital environment, obtaining the correct diagnosis can be more challenging in an austere medical environment, such as that encountered in a forward-deployed combat zone. Here is presented the case of a patient whose testicular cancer was diagnosed using a bedside pregnancy test—one of the few diagnostic tests available at our medical facility to assist with the diagnosis. (Source: The American Journal of Emergency Medicine)

Semen cryopreservation for men banking for oligospermia, cancers, and other pathologies: prediction of post-thaw outcome using basal semen quality

Fertility and Sterility — Thu, 12 Sep 2013 04:00:00 +0100

Conclusion(s): Our study demonstrates the ability of prefreeze semen parameters to predict cryosurvival in terms of sensitivity and precision. Using this information, the clinician could perform appropriate counseling about the future possibilities of fertility for the patient. (Source: Fertility and Sterility)

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Employment participation and work experience of male cancer survivors: A NOCWO study.

Work — Wed, 04 Sep 2013 04:00:00 +0100

CONCLUSIONS: Employment participation and work experiences of male cancer survivors varied substantially according to type of cancer. Occupational therapists and other health care personnel should keep this in mind when assisting cancer survivors in identifying their strengths and limitations at work. PMID: 24004734 [PubMed - as supplied by publisher] (Source: Work)

Testicular cancer.

Nursing Standard — Wed, 04 Sep 2013 04:00:00 +0100

Authors: Abstract Essential facts Testicular cancer is the most common cancer in men between the ages of 15 and 44. About 2,300 men are diagnosed with the disease each year in the UK, making it a relatively rare form of cancer. However, incidence rates are increasing - they have more than doubled in Britain since the mid-1970s, particularly among white men. PMID: 24011226 [PubMed - in process] (Source: Nursing Standard)

Markedly increased incidence and improved survival of testicular cancer in the Netherlands.

Acta Oncologica — Fri, 30 Aug 2013 04:00:00 +0100

Conclusion. This study shows that incidence of TC has increased sharply in the Netherlands. Relative survival is high and improved in most disease stages. There is a growing demand for medical care of newly diagnosed TC patients and for the rapidly increasing number of prevalent TC patients. PMID: 23992111 [PubMed - as supplied by publisher] (Source: Acta Oncologica)

Is Paclitaxel-based chemotherapy the way forward in testicular cancer?

Indian Journal of Urology — Thu, 29 Aug 2013 04:00:00 +0100

Vivek VenkatramaniIndian Journal of Urology 2013 29(3):268-269 (Source: Indian Journal of Urology)

Optimizing treatment of seminoma stage IIA/B step by step

Annals of Oncology — Wed, 28 Aug 2013 04:00:00 +0100

(Source: Annals of Oncology)

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[Clinical stage I seminoma : Is surveillance a new therapy standard?]

Der Urologe. Ausg. A — Wed, 28 Aug 2013 04:00:00 +0100

DISCUSSION: In this review, recent data on the long-term effects of adjuvant radiotherapy and chemotherapy, the question of risk stratification as well as the advantages and limitations of a surveillance strategy are discussed. PMID: 23979446 [PubMed - as supplied by publisher] (Source: Der Urologe. Ausg. A)

The Effects of Chemotherapy with Bleomycin, Etoposide, and Cis-Platinum (BEP) on Rat Sperm Chromatin Remodeling, Fecundity and Testicular Gene Expression in the Progeny.

Biology of Reproduction — Wed, 28 Aug 2013 04:00:00 +0100

Authors: Maselli J, Hales BF, Robaire B Abstract During spermiogenesis histones are replaced first by transition proteins and then by protamines resulting in a very condensed sperm DNA structure that is absolutely critical for normal sperm function. We have demonstrated previously that, despite a 9-wk recovery period, mature sperm from rats treated for 9 wk with bleomycin, etoposide, and cis-platinum (BEP), the drugs used to treat testicular cancer, have reduced levels of protamine 1 and a concomitant upregulation of specific histones, highlighting a problem in histone eviction. Here, we demonstrate that regulators of histone removal are increased in elongating spermatids following recovery; however, Ac-H4 and gammaH2AX histones remain elevated in elongating spermatids or caudal ep...

Targeted serum miRNA (TSmiR) test for diagnosis and follow-up of (testicular) germ cell cancer patients: A proof of principle

Molecular Oncology — Wed, 28 Aug 2013 04:00:00 +0100

Abstract: Germ cell cancers (GCC) are the most frequent malignancy in young Caucasian males. GCC can consist of seminomas (SE) and non-seminomas (malignant NS: embryonal carcinoma (EC), yolk sac tumor (YS), choriocarcinoma (CH) and teratoma (TE)). Current serum-markers used for diagnosis and follow-up (AFP, hCG) are predominantly related to YS and CH and marker positivity can vary during disease. Therefore, stable markers consistently identifying more GCC components, specifically the stem cell components SE and EC, are of interest. Expression of the embryonic stem cell miR-371-3 and miR-302/367 clusters in SE/EC/YS suggest possible application of these micro-RNAs as GCC tumor-markers. The TSmiR protocol constitutes a complete, quality-controlled pipeline for the detection of miRs in serum,...

Why I am laughing in the face of cancer

Daily Express - Health — Mon, 26 Aug 2013 23:00:00 +0100

THE last thing Adam Hart felt like doing when a hospital consultant gave him a grave diagnosis was to laugh. However the part-time comedian has turned his experience of surviving testicular cancer into an unlikely source of gags for his stand-up comedy routine. (Source: Daily Express - Health)

[National second-opinion network for testicular cancer patients : Results of a user survey.]

Der Urologe. Ausg. A — Wed, 21 Aug 2013 04:00:00 +0100

Authors: Zengerling F, Schrader AJ, Mohr A, Schrader M Abstract BACKGROUND: The national second opinion project of the German Testicular Cancer Study Group (GTCSG) has served to improve the quality of care provided to testicular cancer patients since 2006. AIM: A recent online survey was carried out to characterize the users of the second opinion offer and clarify their motivation for participating in the project. Furthermore, the aim was to identify weaknesses of the project which could be improved. A total of 440 users of the second opinion project were contacted of whom 192 participated in the survey. RESULTS: In summary, the data collected showed a high degree of satisfaction among the participants who appreciated the second opinions received. Some issues with a need fo...

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Long-term side-effects in testicular cancer could be reduced by chemotherapy before radiotherapy

Health News from Medical News Today — Tue, 20 Aug 2013 07:00:00 +0100

Giving men with testicular cancer a single dose of chemotherapy alongside radiotherapy could improve the effectiveness of treatment and reduce the risk of long-term side-effects, a new study reports. As many as 96% of men with testicular cancer now survive at least ten years from diagnosis (1), but more advanced forms need to be treated with combination chemotherapy - which can have serious long-term complications... (Source: Health News from Medical News Today)

Abdominal visceral and subcutaneous fat increase, insulin resistance and hyperlipidemia in testicular cancer patients treated with cisplatin-based chemotherapy.

Acta Oncologica — Mon, 19 Aug 2013 04:00:00 +0100

Conclusion. Cisplatin-based chemotherapy was associated with acute insulin resistance, dyslipidemia and an immediate increase in abdominal visceral adipose tissue and abdominal subcutaneous adipose tissue in testicular cancer patients. A large prospective cohort study with long follow-up is warranted to characterize the time course and relationship between acutely induced obesity and hypercholesterolemia and the development of metabolic syndrome and CVD years later in individual testicular cancer survivors. PMID: 23957624 [PubMed - as supplied by publisher] (Source: Acta Oncologica)

Testicular cancer and viral infections: A systematic literature review and meta‐analysis

Journal of Medical Virology — Mon, 19 Aug 2013 04:00:00 +0100

Abstract In 1984, Newell and coworkers were the first to suggest that testicular cancer might have a viral etiology since it showed similar characteristics to Hodgkin's lymphoma. A systematic literature review and meta‐analysis was conducted to investigate a possible association between viral infections (EBV, CMV, Parvovirus B19, HPV, and HIV) and testicular cancer. Articles published from 1985 through June 2010 were located from MEDLINE and EMBASE databases, 21 articles were finally included in the review. For infection with EBV, CMV, Parvovirus B19, and HIV the pooled OR were 4.80 (95% CI 0.98–23.54), 1.85 (95% CI 0.92–3.70), 2.86 (95% CI 0.35–23.17), and 1.79 (95% CI 1.45–2.21) respectively. No pooling was possible for HPV infection studies due to small numbers. The results su...

Chemotherapy before radiotherapy for testicular cancer could reduce long-term side-effects

EurekAlert! - Medicine and Health — Fri, 16 Aug 2013 04:00:00 +0100

(Institute of Cancer Research) Giving men with testicular cancer a single dose of chemotherapy alongside radiotherapy could improve the effectiveness of treatment and reduce the risk of long-term side-effects, a new study reports.As many as 96% of men with testicular cancer now survive at least ten years from diagnosis, but more advanced forms need to be treated with combination chemotherapy -- which can have serious long-term complications. (Source: EurekAlert! - Medicine and Health)

miR-142-3p Inhibits PTPN23 Expression in TGCTs [Cell Biology]

Journal of Biological Chemistry — Fri, 16 Aug 2013 04:00:00 +0100

Protein-tyrosine phosphatase non-receptor type 23 (PTPN23) is a candidate tumor suppressor involved in the tumorigenesis of various organs. However, its physiological role(s) and detailed expression profile(s) have not yet been elucidated. We investigated the function and regulation of PTPN23 in the formation of testicular germ cell tumors (TGCTs). Expression of PTPN23 in human TGCT cell lines was significantly lower than that in spermatogonial stem cells in mice. Overexpression of PTPN23 in NEC8, a human TGCT cell line, suppressed soft agar colony formation in vitro and tumor formation in nude mice in vivo. These data indicate that PTPN23 functions as a tumor suppressor in TGCTs. Multiple computational algorithms predicted that the 3′ UTR of human PTPN23 is a target for miR-142-3p. A lu...

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[Surgery of inferior vena cava-associated urological tumor lesions.]

Der Urologe. Ausg. A — Thu, 15 Aug 2013 04:00:00 +0100

CONCLUSIONS: The current development status and advances in surgical approaches as well as advances in medical technology allow the successful approach to such advanced stage urological tumor manifestations. A deciding factor is the abdominal and cardiovascular surgical expertise of each surgeon after formation of a team of surgical specialists (including urologists) and only then prognostic advantages can be achieved. PMID: 23942738 [PubMed - as supplied by publisher] (Source: Der Urologe. Ausg. A)

Allelotyping analysis suggesting a consecutive progression from intratubular germ cell neoplasia to seminoma and then to embryonal carcinoma of the adult testis

Human Pathology — Mon, 12 Aug 2013 04:00:00 +0100

Summary: Among adult testicular germ cell tumors, the pathogenesis of embryonal carcinoma remains a matter of debate. Some studies suggest a single consecutive progression from intratubular germ cell neoplasia, unclassified (IGCNU), to seminoma and then to embryonal carcinoma; others suggest that seminoma and embryonal carcinoma derive independently from IGCNU. This allelotyping study aimed to clarify the genetic relationship between embryonal carcinoma components and coexisting seminoma and/or IGCNU components. From a cohort of 18 patients with embryonal carcinoma, 11 coexisting seminoma components and 14 coexisting IGCNUs were identified. DNA isolated from each laser-microdissected tissue was subjected to polymerase chain reaction and loss of heterozygosity (LOH) analysis, using 20 polym...

Null Association Between Histology of First and Second Primary Malignancies in Men With Bilateral Testicular Germ Cell Tumors.

Am J Epidemiol — Thu, 08 Aug 2013 04:00:00 +0100

Authors: Thomas JP, Davis-Dao C, Lewinger JP, Siegmund KD, Hamilton AS, Daneshmand S, Skinner EC, Thomas DC, Cortessis VK Abstract Testicular germ cell tumors (TGCTs), the most common neoplasms of young men, are categorized histologically as either seminomas or nonseminomas/mixed germ cell tumors. These subtypes differ by age at diagnosis and clinical course, but little is known about etiological distinctions. To test the hypothesis that histological subtypes have distinct sets of unrecognized etiological factors, we used a recently described approach, estimating the association between histological types of first and second tumors of men with 2 primary TGCTs. The study population of 488 men each with 2 primary TGCTs was ascertained through population-based cancer registries in the...

Effect of the time from the presentation of symptoms to medical consultation on primary tumor size and survival in patients with testicular cancer: Shift in the last 2 decades

Urologic Oncology: Seminars and Original Investigations — Mon, 05 Aug 2013 04:00:00 +0100

Abstract: Objectives: To clarify the effect of the time from the presentation of symptoms to medical consultation (time to consultation) on oncological outcomes in men with testicular cancer and to examine whether the recent improvement of delays in consultation has led to better outcomes.Methods: We reviewed 175 consecutive patients registered for testicular cancer (124 men with seminoma and 51 men with nonseminoma) at a single institution between 1991 and 2010.Results: Men with the time to consultation of>6 months (n = 56) had a poorer overall survival than those with the time to consultation of ≤6 months (log-rank test, P = 0.028), despite similar disease stage between them (P = 0.897) and less prevalent nonseminoma in the former (P = 0.032). Although the negative effect of consultati...

Phosphorylation of Tyr-823 Is Crucial for c-Kit Signaling [Cell Biology]

Journal of Biological Chemistry — Fri, 02 Aug 2013 04:00:00 +0100

The receptor tyrosine kinase c-Kit, also known as the stem cell factor receptor, plays a key role in several developmental processes. Activating mutations in c-Kit lead to alteration of these cellular processes and have been implicated in many human cancers such as gastrointestinal stromal tumors, acute myeloid leukemia, testicular seminomas and mastocytosis. Regulation of the catalytic activity of several kinases is known to be governed by phosphorylation of tyrosine residues in the activation loop of the kinase domain. However, in the case of c-Kit phosphorylation of Tyr-823 has been demonstrated to be a late event that is not required for kinase activation. However, because phosphorylation of Tyr-823 is a ligand-activated event, we sought to investigate the functional consequences of Ty...

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Clusterin expression and human testicular seminoma

Medical Hypotheses — Mon, 29 Jul 2013 04:00:00 +0100

Abstract: Clusterin expression has a positive correlation with the occurrence and progression of various types of tumors from different genetic backgrounds. Clusterin overexpression may protect tumor cells from apoptosis and damage caused by autoimmunity or anti-tumor therapy. Using immunohistochemisty, one previous study showed that clusterin protein expression is downregulated in human testicular seminoma, which is highly sensitive to radiotherapy and chemotherapy. We thus postulate that clusterin expression in human testicular seminoma differs from clusterin expression in other tumors. It may be the cause of the treatable characteristics of testicular seminoma. In the present preliminary study, we detected the abundance of clusterin mRNA in human testicular seminoma and normal testis. T...

Almost all survive testicular cancer: 96% of men diagnosed with the disease are still alive ten years later

the Mail online | Health — Mon, 29 Jul 2013 01:10:49 +0100

Although there is a slim chance of the disease returning, patients who have survived for more than a decade are considered effectively cured. (Source: the Mail online | Health)

Testicular cancer survival 'soaring'

BBC News | Health | UK Edition — Mon, 29 Jul 2013 00:57:06 +0100

The overwhelming majority of men with testicular cancer will now survive for at least 10 years, figures released by Cancer Research UK show. (Source: BBC News | Health | UK Edition)

Chromosome X-encoded Cancer/Testis antigens are less frequently expressed in non-seminomatous germ cell tumors than in seminomas.

Cancer Immunity — Sun, 28 Jul 2013 19:05:02 +0100

Authors: Chen YT, Cao D, Chiu R, Lee P Abstract Cancer/Testis (CT) antigens are normally only expressed in germ cells and yet are aberrantly activated in a wide variety of human cancers. Most chromosome X-encoded CT antigens (CT-X) show restricted expression in pre-meiotic germ cells in adult testis, except for the expression of SPANX in post-meiotic germ cells. In the present study, the expression of eight CT-X antigens (MAGE-A, NY-ESO-1, GAGE, MAGE-C1/CT7, MAGE-C2/CT10, CT45, SAGE1, and SPANX) in non-seminomatous germ cell tumors was evaluated immunohistochemically, including 24 embryonal carcinomas, 20 yolk sac tumors, 9 teratomas, and 3 choriocarcinomas, and the results were compared to our previous study of 77 classic seminomas and 2 spermatocytic seminomas. SPANX was not dete...

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Immunohistochemical Studies of Metastatic Germ-Cell Tumors in Retroperitoneal Dissection Specimens: A Sensitive and Specific Panel

International Journal of Surgical Pathology — Fri, 26 Jul 2013 04:00:00 +0100

In conclusion, SALL4 and NANOG are sensitive and specific markers for GCTs. GPC3, D2-40, and CD30 are sensitive but not specific for individual components of GCTs and may be useful in aiding in the differential diagnosis for the individual component of GCTs when the identity of GCT is established. (Source: International Journal of Surgical Pathology)

Man who had testicle removed discovers 'cancer' was actually varicose vein

Telegraph Health — Mon, 22 Jul 2013 13:30:36 +0100

A man who was diagnosed with testicular cancer and had a testicle removed has claimed doctors ruined his life after it emerged he only had an enlarged varicose vein. (Source: Telegraph Health)

Man discovers cancer was varicose vein seven years after treatment

Telegraph Health — Mon, 22 Jul 2013 13:30:36 +0100

A man who was diagnosed with testicular cancer and had a testicle removed has claimed doctors ruined his life after it emerged he only had an enlarged varicose vein. (Source: Telegraph Health)

Neoadjuvant carboplatin before radiotherapy in stage IIA and IIB seminoma

Annals of Oncology — Mon, 22 Jul 2013 04:00:00 +0100

Conclusions The results of this pilot study suggest that a single cycle of neoadjuvant carboplatin before radiotherapy may reduce recurrence risk compared with radiotherapy alone and permit a smaller radiation field, and this approach is proposed for further investigation. (Source: Annals of Oncology)

Expression of syndecan-4 and correlation with metastatic potential in testicular germ cell tumours.

Biomed Res — Tue, 16 Jul 2013 06:45:02 +0100

Authors: Labropoulou VT, Skandalis SS, Ravazoula P, Perimenis P, Karamanos NK, Kalofonos HP, Theocharis AD Abstract Although syndecan-4 is implicated in cancer progression, there is no information for its role in testicular germ cell tumours (TGCTs). Thus, we examined the expression of syndecan-4 in patients with TGCTs and its correlation with the clinicopathological findings. Immunohistochemical staining in 71 tissue specimens and mRNA analysis revealed significant overexpression of syndecan-4 in TGCTs. In seminomas, high percentage of tumour cells exhibited membranous and/or cytoplasmic staining for syndecan-4 in all cases. Stromal staining for syndecan-4 was found in seminomas and it was associated with nodal metastasis (P = 0.04), vascular/lymphatic invasion (P = 0.01), and dis...

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Relationship between primary and metastatic testicular germ cell tumors: a clinicopathologic analysis of 100 cases

Human Pathology — Mon, 15 Jul 2013 04:00:00 +0100

Summary: Testicular germ cell tumors (GCTs) commonly metastasize to the retroperitoneal lymph nodes (RPLNs). We evaluated 100 cases of RPLN dissection specimens with viable GCTs after chemotherapy and compared them with their corresponding orchiectomy specimens. The mean age of patients was 28 years (range, 15–58 years). The testicular tumors consisted of mixed GCT (n = 72), teratoma (n = 18), seminoma (n = 4), embryonal carcinoma (n = 3), yolk sac tumor (n = 1), and no viable tumor (n = 2). Somatic malignant components were found in 5 cases. The metastatic tumors in the RPLNs consisted of only teratoma (n = 77) and non-teratomatous GCT (n = 23). Twenty-one patients had only teratoma in the RPLNs but not in the testis, and 10 patients had metastatic non-teratomatous GCT components that w...

The relevance of increased cancer risk in infertile men

Fertility and Sterility — Mon, 08 Jul 2013 04:00:00 +0100

The authors from Baylor College of Medicine have presented interesting information on the risk of subsequently having a cancer diagnosis after being found to be azoospermic on semen analysis or having a male factor infertility diagnosis . The increased cancer risk identified in these men was greatest for the azoospermic patients. Prior studies have documented an increased risk of testicular cancer in men evaluated for infertility , and one of the most important reasons to have a urologist involved with the care of infertile men is the risk of infertility being a symptom of a more sinister or important medical condition, such as pituitary tumors, erectile dysfunction, or other abnormalities . These findings emphasize the critical importance of male factor evaluation by an expert who has a c...

The prevalence and correlates of supportive care needs in testicular cancer survivors: a cross‐sectional study

Psycho-Oncology — Wed, 03 Jul 2013 04:00:00 +0100

ConclusionsThe majority of TC survivors reported one or more unmet needs. Unmet needs regarding existential survivorship issues were frequently reported by TC survivors despite their favorable prognosis. Relationships unmet needs were less prevalent but still more common than in breast and gynecological cancer survivors. These findings appear to be related to the young age of TC survivors. As a higher number of unmet needs is significantly associated with psychological morbidity and impaired HRQoL, interventions addressing this constellation of issues are needed. Copyright © 2013 John Wiley & Sons, Ltd. (Source: Psycho-Oncology)

Erectile Dysfunction In Men Treated For Testicular Cancer

BJU International — Sun, 30 Jun 2013 15:15:04 +0100

ConclusionsMen with TC presenting with ED after treatment appear to uniformly have normal erectile hemodynamics, suggesting adrenaline‐mediated ED. While the majority of TC survivors with ED respond successfully to PDE5i, a significant minority do not. (Source: BJU International)

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Treatment burden in stage I seminoma: a comparison of surveillance and adjuvant radiation therapy

BJU International — Thu, 27 Jun 2013 04:00:00 +0100

ConclusionsSurveillance reduces overall treatment burden in stage I seminoma patients and is the preferred management. RT selectively used at first relapse on surveillance leads to a comparable requirement for subsequent chemotherapy as aRT. (Source: BJU International)

Patterns of management and surveillance imaging amongst medical oncologists in Australia for stage I testicular cancer

BJU International — Tue, 25 Jun 2013 04:00:00 +0100

Conclusion We found considerable variation in management patterns. The infrequent use of surveillance and frequent use of carboplatin for seminoma differs from international guidelines. Radiation exposure from CT imaging should be reduced through standardized follow‐up protocols, and possibly by alternate imaging methods if validated in appropriate studies. (Source: BJU International)

Re: An Alternative Treatment Regimen of Advanced Seminoma with Carboplatin, Etoposide, and Bleomycin instead of Cisplatin-Based Therapy

The Journal of Urology — Mon, 24 Jun 2013 04:00:00 +0100

E. Giesen, A. Mager, H. van Tinteren, S. Rodenhuis and M. Kerst Department of Medical Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands (Source: The Journal of Urology)

PARP expression in germ cell tumours

Journal of Clinical Pathology — Fri, 21 Jun 2013 04:00:00 +0100

Conclusions In this pilot study, we showed for the first time, that PARP is overexpressed in testicular germ cell tumours compared to normal testis. (Source: Journal of Clinical Pathology)

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International geographic correlation study of the prevalence of disorders of male reproductive health

Human Reproduction — Tue, 18 Jun 2013 04:00:00 +0100

STUDY QUESTION Is there evidence at the population level of associations between different male genital disorders, outside Scandinavian countries? SUMMARY ANSWER At an international scale, there is evidence for a number of correlations between rates of four male reproductive disorders (hypospadias, cryptorchidism, testicular cancer and low sperm concentration). WHAT IS KNOWN ALREADY Some associations between these outcomes have been shown in studies focusing on individuals and mainly in Nordic European countries. These associations, together with histological evidence of a dysgenesis pattern in testicular tissue specimens, have generated the concept of the existence of a ‘testicular dysgenesis syndrome’ originating in utero. STUDY DESIGN, SIZE, DURATION This is a geographica...

ASCO: Post-Surgery Surveillance Found Safe in Seminoma

Cancer Network — Mon, 17 Jun 2013 12:00:00 +0100

Surveillance of patients with stage I seminoma following orchiectomy can spare a majority of patients from adjuvant chemotherapy with a low risk of relapse, according to results presented at the 2013 ASCO meeting. (Source: Cancer Network)

Contrasting effects of Deadend1 (Dnd1) gain and loss of function mutations on allelic inheritance, testicular cancer, and intestinal polyposis

BMC Genetics - Latest articles — Mon, 17 Jun 2013 04:00:00 +0100

Conclusion: These results show that Dnd1 is essential for normal allelic inheritance and that Dnd1Ter has a novel combination of functions that significantly increase risk for both testicular and intestinal cancer. (Source: BMC Genetics - Latest articles)

The role of OCT4 immunohistochemistry in evaluation of retroperitoneal lymph node dissections: a pilot study

Modern Pathology AOP — Fri, 14 Jun 2013 04:00:00 +0100

Authors: Muhammad T Idrees, Sean R Williamson, Theodore W Kieffer & Liang Cheng (Source: Modern Pathology AOP)

Re: A Meta-Analysis of the Risk of Boys with Isolated Cryptorchidism Developing Testicular Cancer in Later Life

The Journal of Urology — Thu, 06 Jun 2013 04:00:00 +0100

S. Z. Lip, L. E. Murchison, P. S. Cullis, L. Govan and R. Carachi School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom (Source: The Journal of Urology)

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Solitary Bony Metastasis in Seminoma [DIAGNOSIS IN ONCOLOGY]

Journal of Clinical Oncology — Wed, 29 May 2013 04:00:00 +0100

(Source: Journal of Clinical Oncology)

Transcriptome profiling of mice testes following low dose irradiation

Reproductive Biology and Endocrinology — Tue, 28 May 2013 04:00:00 +0100

Conclusions: The five clusters represent gene expression in distinct cell types of the adult testis. We observed large expression changes in the somatic cell profile, which mainly could be attributed to changes in cellularity, but hyperplasia of Leydig cells may also play a role. We speculate that the possible hyperplasia may be caused by lower testosterone production and inadequate inhibin signalling due to missing germ cells. (Source: Reproductive Biology and Endocrinology)

Genetics: New susceptibility loci for testicular cancer identified

Nature Clinical Practice Oncology — Tue, 28 May 2013 04:00:00 +0100

Nature Reviews Clinical Oncology 10, 368 (2013). doi:10.1038/nrclinonc.2013.90 Two new studies have added to the body of knowledge on the chromosomal loci associated with testicular germ cell tumour (TGCT), which is known for high familial risk. The first, a meta-analysis, involved the analysis of >900 men with TGCT and >1,900 controls included in (Source: Nature Clinical Practice Oncology)

Frequency of computed tomography examinations in the follow-up care of testicular cancer patients - an evaluation of patterns of care in Germany.

Onkologie — Fri, 24 May 2013 20:30:02 +0100

CONCLUSION: There is a considerable gap between recommendation and actual performance regarding the number of CT scans applied to testicular cancer patients. Unfamiliarity of clinicians with guidelines as well as poor acceptance of high numbers of CT scans scheduled may have contributed to create this particular pattern of care. PMID: 23548967 [PubMed - in process] (Source: Onkologie)

Curcumin inhitis AP-2γ-induced apoptosis in the human malignant testicular germ cells in vitro.

Acta Pharmacologica Sinica — Mon, 20 May 2013 04:00:00 +0100

Conclusion:Curcumin induces apoptosis and inhibits proliferation in NTera-2 cells via the inhibition of AP-2γ-mediated downstream cell survival signaling pathways. PMID: 23685957 [PubMed - as supplied by publisher] (Source: Acta Pharmacologica Sinica)

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Clinical outcomes in patients with stage I non-seminomatous germ cell cancer.

Asian Journal of Andrology — Mon, 20 May 2013 04:00:00 +0100

This study assesses the long-term outcomes in Han Chinese patients with clinical stage I non-seminomatous germ cell testicular cancer (CSI NSGCT) treated with surveillance, retroperitoneal lymph node dissection (RPLND) and adjuvant chemotherapy. We retrospectively evaluated 89 patients with a mean age of 26.5 years. After orchiectomy, 37 patients were treated with surveillance, 34 underwent RPLND and 18 were managed with chemotherapy. The overall survival rate, the recurrence-free survival rate and the risk factors were evaluated. The median follow-up length was 92 months (range: 6-149 months). Thirteen of the 89 patients (14.6%) had relapses, and one died by the evaluation date. The overall survival rate was 98.9%. The cumulative 4-year recurrence-free rates were 80.2%, 92.0% and 100% for...

Genomics Studies Identify Testicular Cancer Risk Variants

Cancer Network — Fri, 17 May 2013 12:00:00 +0100

Two genome-wide studies have identified a total of 12 new genetic loci associated with a higher risk of testicular cancer. The risk-associated genetic variations could help clinicians single out higher-risk men for screening and early detection. (Source: Cancer Network)

Early Stage Testicular Cancer - Surveillance Is Best Follow-Up Strategy

Health News from Medical News Today — Fri, 17 May 2013 07:00:00 +0100

A long-term study of men with stage I seminoma, a common form of testicular cancer, suggests that surveillance for cancer recurrence, rather than additional chemotherapy or radiation therapy, is sufficient for the vast majority of patients who have undergone successful surgery for their cancer. In a new long-term study conducted in Denmark, researchers analyzed a national clinical database and found that 99.6% of patients who only underwent surveillance (following a successful surgery) were alive after 10 years of being diagnosed with testicular cancer... (Source: Health News from Medical News Today)

ASCO: Surveillance for Early Seminoma Found Safe

MedPage Today Surgery — Thu, 16 May 2013 19:47:55 +0100

CHICAGO (MedPage Today) -- Most men with stage I seminoma can safely enter surveillance and avoid unnecessary therapy without jeopardizing survival, according to data from a large registry. (Source: MedPage Today Surgery)

Surveillance Sufficient After Surgery in Early SeminomaSurveillance Sufficient After Surgery in Early Seminoma

Medscape Today Headlines — Thu, 16 May 2013 15:45:26 +0100

Survival after surgery in stage I seminoma is excellent, and new data show that surveillance is sufficient for most patients. Medscape Medical News (Source: Medscape Today Headlines)

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Postsurgical surveillance sufficient for men with stage I seminoma

HemOncToday.com — Thu, 16 May 2013 00:00:00 +0100

(Source: HemOncToday.com)

4 New Genetic Risk Factors Identified For Testicular Cancer

Health News from Medical News Today — Tue, 14 May 2013 08:00:00 +0100

A new study looking at the genomes of more than 13,000 men identified four new genetic variants associated with an increased risk of testicular cancer, the most commonly diagnosed type in young men today. The findings from this first-of-its-kind meta-analysis were reported online in Nature Genetics by researchers at the Perelman School of Medicine at the University of Pennsylvania... (Source: Health News from Medical News Today)

Genetic Risk Factors for Testicular Cancer

Medical Headlines From Ivanhoe.com — Tue, 14 May 2013 05:00:00 +0100

(Ivanhoe Newswire) – Researchers from the Perelman School of Medicine at the University of Pennsylvania recently discovered four genetic variations strongly linked to an increased risk of testicular cancer. (Source: Medical Headlines From Ivanhoe.com)

Scientists Discover More Genetic Clues to Testicular Cancer

MedicineNet Cancer General — Mon, 13 May 2013 07:00:00 +0100

Title: Scientists Discover More Genetic Clues to Testicular CancerCategory: Health NewsCreated: 5/12/2013 2:35:00 PMLast Editorial Review: 5/13/2013 12:00:00 AM (Source: MedicineNet Cancer General)

Excess deaths among seminoma patients persist

MedWire News - Oncology — Mon, 13 May 2013 00:00:00 +0100

US research shows that men diagnosed with stage I seminoma since the advent of contemporary radiotherapy have a significantly increased risk for all-cause mortality compared with the overall population, despite being unlikely to die from testicular cancer itself. (Source: MedWire News - Oncology)

Scientists Discover More Genetic Clues to Testicular Cancer

The Doctors Lounge - Oncology — Sun, 12 May 2013 19:00:00 +0100

Disease risk is strongly tied to family history (Source: The Doctors Lounge - Oncology)

Second to fourth digit ratio, handedness and testicular germ cell tumors

Early Human Development — Sun, 12 May 2013 18:10:44 +0100

Conclusions: These results do not support the hypothesis that prenatal hormonal imbalance is associated with TGCT risk. Given the limited sample size, further evaluation of the relationship between TGCT and prenatal hormonal factors using digit ratio, ΔR−L, or left-hand dominance and larger sample size are warranted. (Source: Early Human Development)

Penn Medicine researchers identify 4 new genetic risk factors for testicular cancer

EurekAlert! - Medicine and Health — Sun, 12 May 2013 04:00:00 +0100

(University of Pennsylvania School of Medicine) A new study in Nature Genetics looking at the genomes of more than 13,000 men identified four new genetic variants associated with an increased risk of testicular cancer, the most commonly diagnosed type in young men today. (Source: EurekAlert! - Medicine and Health)

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Identification of nine new susceptibility loci for testicular cancer, including variants near DAZL and PRDM14

Nature Genetics — Sun, 12 May 2013 04:00:00 +0100

Nature Genetics 45, 686 (2013). doi:10.1038/ng.2635 Authors: Elise Ruark, Sheila Seal, Heather McDonald, Feng Zhang, Anna Elliot, KingWai Lau, Elizabeth Perdeaux, Elizabeth Rapley, Rosalind Eeles, Julian Peto, Zsofia Kote-Jarai, Kenneth Muir, Jeremie Nsengimana, Janet Shipley, D Timothy Bishop, Michael R Stratton, Douglas F Easton, Robert A Huddart, Nazneen Rahman & Clare Turnbull Testicular germ cell tumor (TGCT) is the most common cancer in young men and is notable for its high familial risks. So far, six loci associated with TGCT have been reported. From genome-wide association study (GWAS) analysis of 307,291 SNPs in 986 TGCT cases and 4,946 controls, we selected for follow-up 694 SNPs, which we genotyped in a further 1,064 TGCT cases and 10,082 controls from the UK. We ide...

Do Ethnic Patterns in Cryptorchidism Reflect Those Found in Testicular Cancer?

The Journal of Urology — Fri, 10 May 2013 04:00:00 +0100

Conclusions: Since the principal risk factors for cryptorchidism are present in utero, the results of the current study strengthen the likelihood that the ethnic patterning of testicular cancer is at least partly due to prenatal risk factors. (Source: The Journal of Urology)

Patterns of Management and Surveillance Imaging for Stage I Testicular Cancer amongst Medical Oncologists in Australia

BJU International — Thu, 09 May 2013 04:00:00 +0100

ConclusionWe found considerable variation in management. The infrequent use of surveillance and frequent use of carboplatin for seminoma differs from international guidelines.Radiation exposure from CT imaging should be reduced through standardised follow‐up protocols, and possibly by alternate imaging modalities if validated in appropriate studies. (Source: BJU International)

Men's experiences of sexuality after cancer: a material discursive intra-psychic approach.

Culture, Health and Sexuality — Wed, 08 May 2013 04:00:00 +0100

Authors: Gilbert E, Ussher JM, Perz J, Wong WK, Hobbs K, Mason C Abstract Men can experience significant changes to their sexuality following the onset of cancer. However, research on men's sexuality post-cancer has focused almost exclusively on those with prostate and testicular cancer, despite evidence that the diagnosis and treatment for most cancers can impact on men's sexuality. This Australian qualitative study explores the experiences of changes to sexuality for 21 men across a range of cancer types and stages, sexual orientations and relationship contexts. Semi-structured interviews were analysed with theoretical thematic analysis guided by a material discursive intra-psychic approach, recognising the materiality of sexual changes, men's intrapsychic experience of such chan...