My efforts against Childhood Cancer

Help an International Research Team Fight the Zika Virus

2016-06-04T09:00:00.005+03:00

SummaryThe Zika virus was relatively unknown until 2015, when it made headlines due its rapid spread and its link to severe brain-related deficiencies in newborns born to mothers who contracted the virus while pregnant. Dr. Carolina Horta Andrade, the principal investigator for the new OpenZika project, discusses how she and an international team of researchers are using World Community Grid to accelerate the search for an effective anti-Zika treatment.

Introduction

Few people had heard of the Zika virus before 2015, when it began rapidly spreading in the Americas, particularly in Brazil. The virus is mostly spread byAedes aegypti mosquitoes, although sexual and blood transmission are also possible. A currently unknown percentage of pregnant women who have contracted the Zika virus have given birth to infants with a condition called microcephaly, which results in severe brain development issues. In other cases, adults and children who contract the Zika virus have suffered paralysis and other neurological problems.

Currently, there is no treatment for the Zika virus and no vaccine. Given that Zika has quickly become an international public health concern, my team and I are working with researchers here in Brazil as well as in the United States to look for possible treatments, and we are using World Community Grid to accelerate our project.

Our Goals

The OpenZika project on World Community Grid aims to identify drug candidates to treat the Zika virus in people who have been infected. The project will use software to screen millions of chemical compounds against the target proteins that the Zika virus likely uses to survive and spread in the human body, based on what is known from similar diseases such as dengue virus and yellow fever. As science's knowledge of the Zika virus increases in the coming months and key proteins are identified, the OpenZika team will use the new knowledge to refine our search.

Our work on World Community Grid is only the first step in the larger project of discovering a new drug to fight the Zika virus. Next, we will analyze the data obtained from World Community Grid’s virtual screening to choose the compounds that show the most promise. After we have selected and tested compounds that could be effective in killing the Zika virus, we will publish our results. As soon as we have proven that some of the candidate compounds can actually kill or disable the virus in cell-based tests, we and other labs can then modify the molecules to increase their potency against the virus, while ensuring that these modified compounds are safe and non-toxic.

We are committed to releasing all the results to the public as soon as they are completed, so other scientists can help advance the development of some of these active compounds into new drugs. We hope that OpenZika will include a second stage, where we can perform virtual screenings on many more compounds.

Without this research--and other projects that are studying the Zika virus--this disease could become an even bigger threat due to the rapid spread of the virus by mosquitoes, blood and sexual transmission. The link between the Zika virus in pregnant women and severe brain-based disorders in children could impact a generation with larger than usual numbers of members who have serious neurological difficulties.

And without the resources of World Community Grid, using only the resources of our lab, we would only be able to screen a few thousand compounds against some of the Zika proteins, or it would take years to screen millions of compounds against all Zika proteins. This would severely limit our potential for drug discovery.

Enlisting the help of World Community Grid volunteers will enable us to computationally evaluate over 20 million compounds in just the initial phase (and potentially up to 90 million compounds in future phases). Thus, running the OpenZika project on World Community Grid will allow us to greatly expand the scale of our project, and it will accelerate the rate at which we can obtain the results toward an antiviral drug for the Zika virus.

By working together and sharing our work with the scientific community, many other researchers in the world will also be able to take promising molecular candidates forward, to accelerate progress towards defeating the Zika outbreak.

Please visit www.savethechildren.org and http://www.worldcommunitygrid.org

How you could help WCG

New crunching Gpu

2016-01-22T06:45:00.001+02:00

Hi

Can't wait to get new crunching gpu!
It's shipped and arrives in 2 working days.

It's Asus gtx960 strix
Should give good boost to my crunching.

Thank you

LTDAkiles

Tarvitsemme uusia jäseniä!

2016-01-02T09:22:00.001+02:00

Moi

Pikku hiljaa alan saada koneita kasaan ja boincia jauhamaan. Tammikuun aikana lisää rautaa, jotta makuuhuone pysyy talvipakkasilla lämpimänä ;)

Tarviimme uusia jäseniä ja nykyisten jäsenten aktivoitumista.

Tässä hiukan ohjeita kuinka päästä alkuun:

Käytä tietokoneen joutoaikaa parantamaan sairauksia(Aids,Ebola,Syöpä...), tutkimaan ilmaston lämpenemistä, puhdasta energiaa(aurinkokennoihin paremmin soveltuvia materiaaleja), tekemään 3d-kartta Milkyway galaksista ja tekemään monia muita tieteellisiä tutkimuksia.

Asenna Boinc http://boinc.berkeley.edu/index.php

Käynnistä Boinc ja ensimmäisen käynnistyksen yhteyssä kysyy projektia johon halut liittyä( Voit liittyä myöhemmin toisiin projekteihin Boinc ohjelman ikkunan ylälaidasta löytyvän
"Työkalut"->"Liity projektiin" kohdasta.

Kun olet valinnut projektin, niin Boinc yhdistää projektiin ja kysyy "Oletko jo liittynyt tähän projektiin?" valitse "En, uusi käyttäjä" ja laita sähköpostiosoite ja luo salasana.

Nyt pääset Projektin sivuille luomaan profiiliasi. Anna nimeksi vaikka alias/nick tai vastaava ja paina ok.

Etsi tiimi ja key words kohtaan "My efforts against childhood cancer" ja hae.
Klikkaa My efforts against childhood cancer ja seuraavalla sivulla "Liity tiimiin" (Join this team)

Boinc ohjelmasta huomaat, että Boinc laskee tehtäviä ja monesti asetukset niin kun käytät tietokonetta Boinc lopettaa laskemisen ja laskee vain kun tietokone käyttämättömänä.

Tässä hiukan lisätietoa projekteista:

http://boinc.berkeley.edu/projects.php

Kiitos

LTDAkiles

I'm back

2015-12-24T08:38:00.001+02:00

Hi everyone

I had to take a break from Boinc and other internet activities for family reasons.
Here's a short list what was going on:

- Spent 100% efforts for recovery from injury (took 4 years with bad pains and physical training), but now i have been 100% and pain free over a year now.

- It's a boy and and 2 years later it's a girl. Two kids born, it's 4 kids total now. Have spend a lot of time with them so they could have childhood that i never had( Dad at home)

- This year my focus was to get my job licences in order and to find a job. I have something coming up early next year for primary job and i have a contract at my desk all signed for second job(my evening job).

- Powerlifting to get my physical condition on bar to my job

- Quit smoking and i turned into vaping. Easy and my body thanks me for that decision (i can smell, taste again and no cough).

Now i'm 100%, i'm crunching Boinc again. In coming months i will update my boinc crunchers and might get one or two crunchers online. Hopefully our team members will go active too. It's winter here and all need more warmth from our crunchers ;)

Thank you happy holidays

LTDAkiles

Boinc 7.0.25 Released to public!

2012-04-17T13:14:00.000+03:00

Release of Boinc 7.0.25 makes Poem@home available to crunch with AMD gpu's which is first medical project for AMD gpu's.

Boinc

Use the idle time on your computer (Windows, Mac, or Linux) to cure diseases, study global warming, discover pulsars, and do many other types of scientific research. It's safe, secure, and easy:

Choose projects
Download and run BOINC software
Enter an email address and password.

Boinc homepage for more details

New World Community Grid project: Say No to Schistosoma

2012-02-23T13:55:00.000+02:00

Mission
The mission of the Say No to Schistosoma project is to identify potential drug candidates that could possibly be developed into treatments for schistosomiasis. The extensive computing power of World Community Grid will be used to perform computer simulations of the interactions between millions of chemical compounds and certain target proteins. This will help find the most promising compounds that may lead to effective treatments for the disease.

Significance
Schistosomiasis is a tropical disease caused by parasitic worms that are transmitted by freshwater snails. The disease kills 200,000 people each year and affects over 207 million people. Schistosomiasis is second only to malaria in its socioeconomic devastation. Researchers at the Infórium University in Belo Horizonte and FIOCRUZ-Minas, Brazil, are using World Community Grid to search for chemical compounds which may lead to new drugs for treating the disease.

Approach
A software program called VINA from The Scripps Research Institute in La Jolla, California, will be used to perform the virtual chemistry experiments. These virtual experiments will search to find which of millions of drug compounds might be able to disable particular proteins essential for the parasite's survival. Screening for the best potential drug compounds is an early step in the process of developing effective treatments for the disease. With enough computing power, this screening can be done much more quickly than using conventional laboratory experiments. Existing computers available to the researchers would require approximately 30 years to perform the screening. However, it is estimated that the power of World Community Grid can reduce the time required to one year or less. Information about the best candidate compounds will be published by the scientists, and this information will be available in the public domain for other scientists to build upon with their research. Further laboratory work using the best candidates identified by this project could lead to the development of better drugs to fight schistosomiasis.

Project Status and Findings:
Information about this project is provided on the web pages below and by the project scientists on the Say No to Schistosoma website. If you have comments or questions about this project, please visit the Say No to Schistosoma forum.

Join our World Community Team My efforts against childhood cancer

Referral Race 2012

2012-01-21T00:57:00.001+02:00

Hi team.

We're having a great start for the year 2012 and i want to boost it with small referral race.

Referral race is simple.

1. Crunch in our Boinc team and get at least one friend to join our Boinc team.
2. Soon as your friend is crunching regular(10 000 boinc points from cpu project and 100 000 boinc points from gpu project untill 29/02/2012) Ask your friend to email your nick and project to Akiles@windowslive.com and i will add one ticket from each friend to prize drawal. More friends to join, more tickets and better chances to win.
3. Main prize is NEW Battlefield 3 game download ticket and winner will be announced 29/02/2012.

Everyone can join and chance to win is good. I will add small prizes in the mix if i will receive more.

If you have any questions, please email Akiles@windowslive.com

Thank you
LTDAkiles
Team Captain
Email/Msn: Akiles@windowslive.com

You can join the team by searching team with "My efforts against childhood cancer".

Here is direct links to the team page in our main projects( Click bolded project name)

Milkyway@home : Milkyway@Home uses the BOINC platform to harness volunteered computing resources, creating a highly accurate three dimensional model of the Milky Way galaxy using data gathered by the Sloan Digital Sky Survey. Cpu and AMD Gpus(AMD 4830 or better,5830 or better, 6950 or better)

World Community Grid : World Community Grid brings people together from across the globe to create the largest non-profit computing grid benefiting humanity. It does this by pooling surplus computer processing power. We believe that innovation combined with visionary scientific research and large-scale volunteerism can help make the planet smarter. Our success depends on like-minded individuals - like you. Projects: GO Fight Against Malaria, Drug Search for Leishmaniasis, Computing for Clean Water, The Clean Energy Project - Phase 2, Help Cure Muscular Dystrophy - Phase2, Help Fight Childhood Cancer, Help Conquer Cancer, FightAIDS@Home, Discovering Dengue Drugs - Together - Phase 2

MalariaControl.net :

What is malariacontrol.net?

The malariacontrol.net project is an application that makes use of network computing for stochastic modelling of the clinical epidemiology and natural history of Plasmodium falciparum malaria.

Simulation modeling of malaria

The fight against malaria was given a new impetus by the call for eradication at the Gates Malaria Forum in October 2007, making more but still limited resources available for research, development, and combating malaria. To inform decisions on which new or existing tools to prioritize, we have developed a general platform for comparing, fitting, and evaluating stochastic simulation models of Plasmodium falciparum malaria, programmed in C++ (openmalaria).

We use this to inform the target product profiles for novel interventions like vaccines, addressing questions such as minimal efficacy and duration of effects needed for a vaccine to be worthwhile, and also to optimize deployment of established interventions and integrated strategies. Field trials of interventions consider effects over 1-2 years at most, but the dynamics of immunity and human demography also lead to longer term effects. We consider many different outcomes, including transmission reduction or interruption, illness, hospitalization, or death, as well as economic aspects.

GPUGRID.net is a distributed computing infrastructure devoted to biomedical research. Thanks to the contribution of volunteers, GPUGRID scientists can perform molecular simulations to understand the function of proteins in health and disease. Projects: Cancer : Unveiling mechanisms of drug resistance and malfunctions in cell signalling pathways in Cancer. Hiv/Aids : Modelling the process of how HIV maturation first starts by simulating the activation of one of its key proteins: the protease. Neural disorders : Investigating features of neurologically important proteins that have thus far evaded traditional experimental techniques. Nvidia Gpus

2012 Projects

2012-01-16T17:05:00.000+02:00

For year 2012 projects are:

For Cpu:
World Community Grid
Join here
Malariacontrol.net
Join Team here

For GPU(AMD):

Milkyway@home for DP gpus (48xx,58xx,69xx,79xx-series)
Join Team here
Moo!Wrapper for SP gpus (47xx or lower,57xx or lower,68xxor lower)
Join Team here

For GPU(NVIDIA):

Gpugrid
Join Team here
Primegrid
Join Team here

Almost every project have information how to install Boinc software and how to get started. If you are interested to start or want more information, please email Akiles@windowslive.com

Thank you

Merry Christmas and Happy New Year

2011-12-23T21:57:00.000+02:00

Merry Christmas and Happy New Year.

Thanks team from this great year. Team is growing and crunching. That's why the team was created. Crunch for good cause and making the world a better place for our kids.

LTDAkiles

Please join "My efforts against Childhood Cancer" Team at Malariacontrol.net

2011-12-19T13:12:00.002+02:00

Please Join our teams last crunching rush of 2011 at Malariacontrol.net.

What is malariacontrol.net?

The malariacontrol.net project is an application that makes use of network computing for stochastic modelling of the clinical epidemiology and natural history of Plasmodium falciparum malaria.

Simulation modeling of malaria

The fight against malaria was given a new impetus by the call for eradication at the Gates Malaria Forum in October 2007, making more but still limited resources available for research, development, and combating malaria. To inform decisions on which new or existing tools to prioritize, we have developed a general platform for comparing, fitting, and evaluating stochastic simulation models of Plasmodium falciparum malaria, programmed in C++ (openmalaria).

We use this to inform the target product profiles for novel interventions like vaccines, addressing questions such as minimal efficacy and duration of effects needed for a vaccine to be worthwhile, and also to optimize deployment of established interventions and integrated strategies. Field trials of interventions consider effects over 1-2 years at most, but the dynamics of immunity and human demography also lead to longer term effects. We consider many different outcomes, including transmission reduction or interruption, illness, hospitalization, or death, as well as economic aspects.

Malaria occurs in an enormous variety of ecological settings, and interventions are not always universally applicable. For instance, indoor residual spraying works only with indoor-resting mosquitoes, and insecticide treated mosquito nets only with nocturnal vectors. The best combinations of interventions vary, as do optimal delivery approaches and their health system implications. There are trade-offs between high coverage and costs or feasibility of deployment. Indiscriminate deployment may lead to evolution of drug resistance or insensitivity to other interventions. To support the analysis of these elements we are assembling databases of health system descriptions, intervention costing, and vector bionomics across different malaria ecotypes.

Uncertainties inherent in simulations of complex systems are addressed using probabilistic sensitivity analyses, fitting multiple different models, and basing predictions on model ensembles not single simulations. This requires super-computing, both for statistical fitting (which must simultaneously reproduce a wide range of outcomes across different settings), and for exploring predictions. We obtain this computing power over the internet from spare capacity on the computers of volunteers (malariacontrol.net).

Meetings with potential users of these predicitons are used to promote the models and their predictions to wider communities of malariologists, planners, and policy specialists. We are also developing web-based job submission and analysis systems to increase internet access to models.
This project is supported by

You can join here after adding project to your Boinc Manager :http://www.malariacontrol.net/team_display.php?teamid=3333

"My efforts against childhood cancer" Team Captain is user of the day @Moo!wrapper!

2011-12-16T14:24:00.000+02:00

"My efforts against childhood cancer" Team Captain is user of the day @ Moo!Wrapper
Because of this honor i have ordered AMD Sapphire 6950 for Moo!Wrapper Boinc crunching.
Hopefully this new gpu will generate more points and get more work done for our Boinc team "My efforts against childhood cancer". Hopefully our team will interest new boincers to join our Boinc team.

Please join My efforts against childhood cancer Moo!Wrapper team.

If you are interested about Boinc, want more information or don't know Boinc project just for you, please email Akiles@windowslive.com and i'm happy to help.

Thank you
LTDAkiles

Waiting for Radeon HD 7950 / 7970 / 7990 and Nvidia "Kepler" 28nm

2011-12-10T16:04:00.002+02:00

We "crunchers" will soon get nice new gpus to crunch with. Interesting times again.
I will get most likely at least new AMD HD 7950 or 7970 and maybe Nvidia "Kepler" if it will offer good performance vs Price with good energy efficiency. Let's hope AMD and Nvidia will release quality gpus with equal performance. In that case we the consumers will win, because of the price competition. Hopefully AMD will be strong at Folding@Home and Boinc crunching.

Superlink@Technion

2011-12-10T14:42:00.000+02:00

Superlink@Technion helps geneticists all over the world find disease-provoking genes causing some types of diabetes, hypertension (high blood pressure), cancer, schizophrenia and many others.

Superlink@Technion helps geneticists perform genetic linkage analysis, which is a statistical method used to associate functionality of genes with their location on chromosomes. It typically serves for detecting mutated disease-provoking genes. This analysis can be extremely computationally intensive and has been parallelized for simultaneous execution on many computers. Geneticists submit the data for the analysis via Superlink-online linkage analysis portal. The tasks are then automatically parallelized and scheduled for execution on many computers in the Technion, in the University of Wisconsin in Madison, and also on many computers all over the world.

Your computer can help geneticists perform their analysis faster! All you need to do is download and install a small client, called BOINC. The client will start the computations according to the predefined scheduling policy, which by default is configured to start jobs only at nights and during weekends. The client will pull the data and the executable from our server, perform the computations and then return the results back to the server. The program that will perform the actual computations is called Superlink. It is a well known genetic linkage analysis program developed in our laboratory, and thoroughly tested to make sure that it cannot corrupt any local data. You will also be able to configure your BOINC client to restrict the use of your computer.

My efforts against childhood cancer Team have been created there.

"My efforts against childhood cancer" Team moves to top 4!!

2011-12-07T06:52:00.000+02:00

"My efforts against childhood cancer" Team takes 4th place (Boinc Finnish Team overall points).
Our team is getting good amount of work units done and we are gaining Top 3 daily.
Thanks goes to our great members.

We need more new members to join and crunch with us for the good cause.
If you, your family members or/and friends are interested what we do or just want to use your computer idle time for good cause, Please Join "My efforts against childhood cancer" Team or if you have any questions about Boinc,crunching,hardware or installation i'm happy to help. Please email to Akiles@windowslive.com

22 days until Christmas!

2011-12-02T16:46:00.000+02:00

Only 22 days until Christmas. My kids can't wait for Santa Claus . In finnish Santa is Joulupukki, Christmas is Joulu and Rudolpf the Red nosed Reindeer is Petteri Punakuono. Let's make this Christmas special for the children.

Here is a place for the Christmas spirit. Santa Claus village
Photos are from SantaPark Arctic Circle Rovaniemi, Finland.

Here is a link for livecam feed from Santas office. You can see Santa working.

Making the World a better place for our kids by Donating cpu cycles!

2011-11-23T16:09:00.001+02:00

The Help Fight Childhood Cancer comes to you from the Chiba Cancer Center Research Institute, which is affiliated to Chiba University, located in Chiba prefecture, Japan.

As the name of the project implies, the focus of this project is to try to find novel drugs to treat childhood cancers, namely neuroblastoma.

Neuroblastoma is one of the most frequently occurring solid tumors in children, especially in the first two years of their life, and its clinical outcome is still very poor.

With your help, we hope to do the initial research which could result in discoveries that could lead to the development of novel drugs to treat these complex pediatric tumors.

Although, we expect to finish the project in about 2 years on World Community Grid, your contribution is appreciated as it would take us over 100 years on the computers available to us to finish this computation. Join now!

Latest News from The Help Fight Childhood Cancer project:

After screening 3,000,000 candidate chemicals by molecular imaging and cellular toxicity, our project team has finally identified 7 small chemical compounds which kill several neuroblastoma cells at very low concentration.

From: HFCC

My efforts against childhood cancer Team goes top 20 RAC at Collatz Conjecture!

2011-11-19T11:42:00.001+02:00

My efforts against childhood cancer Team goes top 20 RAC at Collatz Conjecture!
You can check standings here!

Thank you team!

Cancer Wellness Programs: Recovery Through Fitness

2011-11-18T00:05:00.001+02:00

Cancer Wellness Programs: Recovery Through Fitness

   Exercise plays an important role in health and wellness programs, especially for those who have lost their health to cancer. Many cancer recovery programs focus on reclaiming health and wellness through exercise and meditation. They are always tailored to meet the needs of individual cancer patients. Just about anyone can benefit, from breast cancer survivors to those facing rare and trying mesothelioma treatment.

   Cancer wellness programs provide many of the same benefits other exercise programs offer -- better circulation, stronger muscles, and improved energy and stamina. But their benefits go beyond the physical. Cancer patients who engage in exercise experience a decreased isolation, for example, and a remarkable sense of empowerment.

Physical Benefits

   Many cancer patients view their fitness recovery programs as motivating and inspiring. They credit cancer wellness programs with helping them “get back into life,” at a time when it may be hard to get out of bed.

   Conventional treatments are proven to fight cancer aggressively. But patients are usually left with negative side effects, including pain, nausea; sleep problems, anxiety, and depression. Exercise helps patients tolerate treatment better, and it helps them sleep better. In fact, moderate exercise during the treatment phase can alleviate physical pain and eliminate the need for anti-depressants or anti-anxiety medications.

Empowerment

    For most people, undergoing cancer treatment means losing control and power over their own body. Fitness programs, whether they involve gentle stretching movements or more involved exercise, serve to empower cancer survivors.

Motivation

    Motivation is a huge benefit of cancer wellness programs. When cancer patients are motivated to participate in exercise and meditation, they are typically motivated to continue their cancer treatment. They are more inspired and motivated in life, in general, which helps in the recovery process.

Balance

   Many people who managed to maintain physical fitness before cancer are surprised to learn they have lost their sense of balance during treatment. Wellness programs help them find that balance. Classes generally involve balance work and core strength, as well as cardio work and other strengthening exercises. Meditation and affirmation help patients stay focuses and grounded.

According to the National Cancer Institute, physical activity can reduce the risk for developing cancer. Colorectal cancer is one of the more extensively studied cancers with regard to exercise. But fitness is important for people with all cancer types, including endometrial, prostate, mesothelioma, and lung cancers.

Cancer patients are encouraged to stay active between fitness classes, and to continue their exercise work at home. Not only do cancer wellness programs strengthen patients physically, but they also provide emotional and spiritual strength. They also give patients a sense of belonging, so they know they are not alone.

By:
Guest Blogger
David Haas
http://www.mesothelioma.com/blog

Happy 7th Birthday, World Community Grid!

2011-11-15T22:51:00.000+02:00

World Community Grid is 7 years of age today, November 16, 2011, and kudos go to all of our members for donating their computer power each and every day to advance critical humanitarian research!

Since last year, we have accomplished the following:

Looking at the numbers: The following statistical growth was accomplished. (To see the current statistics click here).

Members: 44,000 new members registered

Devices: 241,000 new devices were registered

Computer Run Time: 120,000 years of computer run time were donated

Points: 121 Billion points were awarded

Research Results: 243 Million results were returned

Active Research Projects:
During the last 12 months, World Community Grid continued running the following research projects. Click on the project name to find out more about each project:

Drug Search for Leishmaniasis

Computing for Clean Water

The Clean Energy Project - Phase 2

Discovering Dengue Drugs - Together - Phase 2

Help Cure Muscular Dystrophy - Phase 2

Help Fight Childhood Cancer

Help Conquer Cancer

Human Proteome Folding - Phase 2

FightAIDS@Home

New Research Projects:
During the last 12 months, World Community Grid launched the following research projects. Click on the project name to find out more about each project:

GO Fight Against Malaria

Drug Search for Leishmaniasis

Future project queue:
Proposals for nine additional research projects have been received and are being reviewed at this time. Two of these research projects were announced in a September 7, 2010 press release. The remainder of the projects in review will be announced at launch time.

Additional accomplishments:
The following is a list of additional accomplishments:

World Community Grid recognized as one of IBM's 100 Icons of Progress

World Community Grid research scientists awarded portion of IBM Watson Jeopardy! winnings

Expanded ability to handle growth by taking advantage of the IBM SmartCloud Enterprise

30 Peer Reviewed Research Papers

27 World Community Grid Videos

4 Lecture Series Webcasts:

New World Community Grid project: Go fight against Malaria.

2011-11-14T23:08:00.000+02:00

Mission
The mission of the GO Fight Against Malaria project is to discover promising drug candidates that could be developed into new drugs that cure drug resistant forms of malaria. The computing power of World Community Grid will be used to perform computer simulations of the interactions between millions of chemical compounds and certain target proteins, to predict their ability to eliminate malaria. The best compounds will be tested and further developed into possible treatments for the disease.

Significance
Malaria is one of the three deadliest infectious diseases on earth and is caused by parasites that infect both humans and animals. Female mosquitoes spread the disease by biting infected hosts and passing the parasites to other hosts that they bite later. When these parasites replicate themselves in red blood cells (which the parasites use for food), the symptoms of malaria appear. Malaria initially causes fevers and headaches, and in severe cases it leads to comas or death. Plasmodium falciparum, the parasite that causes the deadliest form of malaria, kills more people than any other parasite on the planet. Over 3 billion people are at risk of being infected with malaria.

Although there are many approved drugs that are able to cure malarial infections, multi-drug-resistant mutant "superbugs" exist that are not eliminated by the current drugs. Because new mutant superbugs keep evolving and spreading throughout the world, discovering and developing new types of drugs that can cure infections by these multi-drug-resistant mutant strains of malaria is a significant global health priority.

Approach
Scientists at The Scripps Research Institute of La Jolla, California, U.S.A., will use IBM's World Community Grid to computationally evaluate millions of candidate compounds against different molecular drug targets from the malaria parasite. If these target molecules can be disabled, then patients infected with malaria can potentially be cured. The computations will estimate the ability of the candidate compounds to disable the particular target molecules needed by the malaria parasite to survive and multiply. Particular priority will be given to targets and candidate compounds which could attack the multi-drug-resistant mutant "superbug" strains of the malaria parasite. The power of World Community Grid can reduce to one (1) year what would take at least one hundred (100) years to complete using the resources normally available to the researchers at The Scripps Research Institute. The results computed on World Community Grid will be available in the public domain for all scientists to use and build upon in their research to develop drugs to fight malaria.

Two weeks with FX-8120 Bulldozer and Corsair H100

2011-11-14T12:50:00.001+02:00

Almost two weeks with FX-8120 Bulldozer and Corsair H100 now.
I have been running Boinc 24/7 with 100% usage for FX-8120,AMD Powercolor 6870 and Nvidia Palit GTX 460 1gb. World Community Grid with Cpu, Moo!wrapper with AMD Powercolor 6870 and Primegrid with Nvidia Palit GTX 460 1gb. Just smooth crunching and I can use internet,Youtube and do all the things i usually do, even PC is crunching Boinc tasks with 100% system usage.

Corsair H100 does good job keeping FX-8120 temps down. I replaced Corsair H100 original fans with two Scythe Gentle Typhoon 1850 rpm fans, because of the noise original fans made and did see temps drop 2 C with Scythe Gentle Typhoons as well.
While crunching no cpu related temperature have past 53 C/127 F. Note: FX-8120 is overclocked to 4 Ghz with two overclocked Gpus with 100% usage in not so big Xigmatek Midgard Midi case. System is powered by very solid and silent PSU Thermaltake ToughPower XT 775W . Motherboard is Gigabyte GA-970A-UD3 and Gigabyte motherboards are perfect with good VRM.

Here is a good review from Corsair H100

My efforts against Childhood Cancer Team is advancing in Boinc Finnish Team standings!

2011-11-10T15:20:00.001+02:00

My efforts against Childhood Cancer Team is in 7th place in Boinc Finnish team standings and we are gaining 6th place team fast.

Check out our team stats HERE!

Thank you to our members and happy crunching for a good cause.

LTDAkiles
Email: Akiles@windowslive.com

One way to make world better place for our kids.

2011-11-09T23:07:00.002+02:00

Easiest way to help scientist reaserch important projects like Help fight childhood cancer or conquer cancer is to join Boinc Grid Computing.
Grid Computing is basically an oversized networked computer that allows a problem to be split into thousands of little problems and hundreds of computer’s (home pc’s, laptops, anything except mobile devices). By distributing an enormous problem to many systems, it can be solved faster and more accurately than relying on a single system to tackle the computations involved.

Use the idle time on your computer (Windows, Mac, or Linux) to cure diseases, study global warming, discover pulsars, and do many other types of scientific research. It's safe, secure, and easy:

Download and run BOINC software
Enter an email address and password.
Once Boinc software is running choose advanced view.
Go to Tools and choose add project.
Choose Project interesting you and add your email and create a password as new user.
Now Boinc starts to download a workunit for your pc to calculate and you are directed to projects your profile page asking your country and Team. To the team spot add "My efforts against childhood cancer". If some projects don't have a team option here, you can see "Find a team" spot page which comes after you have saved your alias.
Now you are in your profile page of project of your choosing. You can setup how your's is beeing used,when,how much and how many cores/gpus. You can leave those alone if it's all new to you.
You're done. Just let your computer do it's job and remember Boinc doesn't continue crunching if you close Boinc manager software. So leave it on. You can follow your stats from projects your profile page and http://boincstats.com/ with user search to see all stats from all of your projects.

You can run BOINC while you are chatting, watching movies or web surfing.

Docking@Home

2011-11-05T05:02:00.002+02:00

Docking@Home is a project which uses Internet-connected computers to perform scientific calculations that aid in the creation of new and improved medicines. The project aims to help cure diseases such as Human Immunodeficiency Virus (HIV). Docking@Home is a collaboration between the University of Delaware, The Scripps Research Institute, and the University of California - Berkeley. It is part of the Dynamically Adaptive Protein-Ligand Docking System project and is supported by the National Science Foundation.

How Does It Work?

Before new drugs can be produced for laboratory testing, researchers must create molecular models and simulate their interactions to reveal possible candidates for effective drugs. This simulation is called docking. The combinations of molecules and their binding orientations are infinite in number. Simulating as many combinations as possible requires a tremendous amount of computing power. In order to reduce costs, researchers have decided that an effective means of generating this computing power is to distribute the tasks across a large number of computers.

How Can I Help?

By downloading a free program developed at University of California - Berkeley called BOINC, you can contribute your computer's idle processing cycles to the Docking@Home project. It's safe, easy to setup, and runs only when you want it to so it won't affect your ability to use your computer. If you are interested in finding out more information, you can read more about the project and the science behind it, or if you are ready to help, you can GET STARTED .

Docking@Home Staff

Papers

First 24 hours with AMD "Bulldozer" FX-8120

2011-11-02T12:17:00.004+02:00

Monday afternoon i got AMD "Bulldozer" FX-8120, finally. Almost 3 weeks waiting cpus arrive to importers and it's finally up and crunching. Corsair H100 (CDON.FI sells it for 87€) takes care of cooling the beast. Corsair H100 is one of the best cooling units in the market and i have tested it with 24/7 Boinc crunching with cpu(AMD Phenom II 1055T and from Monday FX-8120) and two gpus(Powercolor 6870 and Palit GTX460 1gb) 100% usage around the clock. There is alot of heat generated in the Xigmatek Midgard case. Corsair H100 and six Scythe Gentle Typhoons 1850 rpm fans are doing excellent job with cooling.

Overclocking is fun with "Bulldozer". So much tweaking and testing. I love this cpu. With stock voltages 4.0ghz. Only issue i am having is with APM dropping multiple to 14 with benchmarks like Cinebench , Prime95, OCCT, GeekBench and Linx. Issue only happens when stressing all 8 cores to 100% usage with single multihreaded software. If i run 8 times memtest with 100% core usage to all cores or running 8 boinc cpu tasks multiplier doesn't drop and i am getting 100% performance out from Bulldozer. Gigabyte GA-970A-UD3 bios doesn't have any options in it to disable APM function. I have to wait for new Bios and hope Gigabyte adds APM option to it.

I will continue with my Overclocking experiments once i have my time.