Nature Biotechnology is a monthly journal publishing new concepts in biological technology of relevance to bioengineering, medicine, energy, agriculture, food and the environment. It has a magazine covering the commercial, political, ethical, legal and societal aspects of this research. http://feeds.nature.com/nbt/rss/current Nature Publishing Group en © 2026 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. Nature Biotechnology © 2026 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. permissions@nature.com https://www.nature.com/uploads/product/nbt/rss.png http://feeds.nature.com/nbt/rss/current https://www.nature.com/articles/s41587-026-03161-w Nature Biotechnology, Published online: 01 June 2026; doi:10.1038/s41587-026-03161-w

This Perspective positions cellular self-organization as a foundational principle for the origin of multicellular life and discusses how decoding this concept with stem cell-based models will advance biological engineering.]]> Qi ChenMagdalena Zernicka-Goetz doi:10.1038/s41587-026-03161-w Nature Biotechnology, Published online: 2026-06-01; | doi:10.1038/s41587-026-03161-w 2026-06-01 Nature Biotechnology 10.1038/s41587-026-03161-w https://www.nature.com/articles/s41587-026-03161-w https://www.nature.com/articles/s41587-026-03142-z Nature Biotechnology, Published online: 01 June 2026; doi:10.1038/s41587-026-03142-z

Selection increases the purity of blood stem cells bearing targeted homologous recombination.]]> Daniele CanaruttoMartina FiumaraVigneshwaran VenkatesanChiara GaddoniKohei ShiroshitaAngelica VaresiLuisa AlbanoGabriele PelosiAlfredo SilvaClaudia FirritoGiulia SchiroliDeborah CipriaStefano BerettaAngelo AmabileAnna VillaErika ZonariBernhard GentnerAngelo LombardoPietro GenoveseSamuele FerrariLuigi Naldini doi:10.1038/s41587-026-03142-z Nature Biotechnology, Published online: 2026-06-01; | doi:10.1038/s41587-026-03142-z 2026-06-01 Nature Biotechnology 10.1038/s41587-026-03142-z https://www.nature.com/articles/s41587-026-03142-z https://www.nature.com/articles/s41587-026-03158-5 Nature Biotechnology, Published online: 29 May 2026; doi:10.1038/s41587-026-03158-5

Radio waves are shown to modulate fluorescence and associate spin chemistry in proteins.]]> Kun MengLinyan NieJohannes BergerNick R. von GrafensteinStefan WeberLars-Oliver EssenRoberto RizzatoChristopher EinholzErik SchleicherDominik B. Bucher doi:10.1038/s41587-026-03158-5 Nature Biotechnology, Published online: 2026-05-29; | doi:10.1038/s41587-026-03158-5 2026-05-29 Nature Biotechnology 10.1038/s41587-026-03158-5 https://www.nature.com/articles/s41587-026-03158-5 https://www.nature.com/articles/s41587-026-03112-5 Nature Biotechnology, Published online: 27 May 2026; doi:10.1038/s41587-026-03112-5

SIGnature enables scalable cross-dataset analyses by combining explainable artificial intelligence with RNA foundation models.]]> Maxwell P. GoldMiguel ReyesNathaniel DiamantTony KuoEhsan HajiramezanaliJane W. NewburgerMary Beth F. SonPui Y. LeeGabriele ScaliaAicha BenTaiebSharookh B. KapadiaAnupriya TripathiHéctor Corrada BravoGraham HeimbergTommaso Biancalani doi:10.1038/s41587-026-03112-5 Nature Biotechnology, Published online: 2026-05-27; | doi:10.1038/s41587-026-03112-5 2026-05-27 Nature Biotechnology 10.1038/s41587-026-03112-5 https://www.nature.com/articles/s41587-026-03112-5 https://www.nature.com/articles/s41587-026-03131-2 Nature Biotechnology, Published online: 27 May 2026; doi:10.1038/s41587-026-03131-2

QuantUMS implements uncertainty estimation for protein quantification in mass spectrometry.]]> Justus L. GrossmannFranziska KistnerLudwig R. SinnLukasz SzyrwielJuri RappsilberVadim Demichev doi:10.1038/s41587-026-03131-2 Nature Biotechnology, Published online: 2026-05-27; | doi:10.1038/s41587-026-03131-2 2026-05-27 Nature Biotechnology 10.1038/s41587-026-03131-2 https://www.nature.com/articles/s41587-026-03131-2 https://www.nature.com/articles/s41587-026-03180-7 Nature Biotechnology, Published online: 26 May 2026; doi:10.1038/s41587-026-03180-7

Author Correction: DNA-guided CRISPR–Cas12a effectors for programmable RNA recognition and cleavage]]> Xiaolong WuWai Hei LamZibin ZhaoYumeng CaoHaosi LinXianzhen FengYuanliang ZhaiI-Ming Hsing doi:10.1038/s41587-026-03180-7 Nature Biotechnology, Published online: 2026-05-26; | doi:10.1038/s41587-026-03180-7 2026-05-26 Nature Biotechnology 10.1038/s41587-026-03180-7 https://www.nature.com/articles/s41587-026-03180-7 https://www.nature.com/articles/s41587-026-03134-z Nature Biotechnology, Published online: 26 May 2026; doi:10.1038/s41587-026-03134-z

This Comment explores artificial intelligence-driven strategies to accelerate the clinical translation of multimodal wearable sensors. We outline key data-science challenges and highlight disease contexts in which these systems could support therapeutic interventions.]]> Yizhou BianShichao DingCatherine R. JutzelerSheng XuNoé BrasierJoseph Wang doi:10.1038/s41587-026-03134-z Nature Biotechnology, Published online: 2026-05-26; | doi:10.1038/s41587-026-03134-z 2026-05-26 Nature Biotechnology 10.1038/s41587-026-03134-z https://www.nature.com/articles/s41587-026-03134-z https://www.nature.com/articles/s41587-026-03153-w Nature Biotechnology, Published online: 26 May 2026; doi:10.1038/s41587-026-03153-w

Building a living cell from scratch requires overcoming a bottleneck that has remained unresolved despite decades of progress: orchestrating the spatiotemporal integration of core functional modules. To tackle this barrier, the SynCell Asia Initiative outlines a strategy for developing core functional modules followed by their systems-level integration through the establishment of a centralized, artificial intelligence (AI)-driven biofoundry.]]> Zhuojun DaiWataru AokiPimchai ChaiyenMatthew Wook ChangXixian ChenZibo ChenByung-Kwan ChoNan-Nan DengShishen DuJee Loon FooJulius FredensMeifang FuXiaojun HanTomohisa HasunumaNorikazu IchihashiNurulfiza Mat IsaDaisuke KigaDong-Myung KimJongmin KimAkihiko KondoYuishin KosakaKobkul LaotengJoongoo LeeJian LiJunbai LiMing LiSierin LimJianbo LiuXingguo LiuYuan LuNan LuoTomoaki MatsuuraWataru MizunashiYan QiaoAhmad Bazli RamziSang Woo SeoYoshihiro ShimizuKwanwoo ShinLiangfei TianWanwipa VongsangnakBaojun WangCheng-Cai ZhangXian-En ZhangGuoping ZhaoBo ZhengYaoqi ZhouChenli Liu doi:10.1038/s41587-026-03153-w Nature Biotechnology, Published online: 2026-05-26; | doi:10.1038/s41587-026-03153-w 2026-05-26 Nature Biotechnology 10.1038/s41587-026-03153-w https://www.nature.com/articles/s41587-026-03153-w