Nature Biotechnology is a monthly journal publishing new concepts in biological technology of relevance to bioengineering, medicine, energy, agriculture, food and the environment. It has a magazine covering the commercial, political, ethical, legal and societal aspects of this research. http://feeds.nature.com/nbt/rss/current Nature Publishing Group en © 2026 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. Nature Biotechnology © 2026 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. permissions@nature.com https://www.nature.com/uploads/product/nbt/rss.png http://feeds.nature.com/nbt/rss/current https://www.nature.com/articles/s41587-026-03174-5 Nature Biotechnology, Published online: 05 June 2026; doi:10.1038/s41587-026-03174-5

Plant genome editing is multiplexed with twin prime editing.]]> Hongchao LiZhuangzhuang ChaiXiaoli ShiChao SunRui ZhangQiao ZhangZhenyu LiKang ZhangYuan LeiCaixia Gao doi:10.1038/s41587-026-03174-5 Nature Biotechnology, Published online: 2026-06-05; | doi:10.1038/s41587-026-03174-5 2026-06-05 Nature Biotechnology 10.1038/s41587-026-03174-5 https://www.nature.com/articles/s41587-026-03174-5 https://www.nature.com/articles/s41587-026-03162-9 Nature Biotechnology, Published online: 05 June 2026; doi:10.1038/s41587-026-03162-9

Folddisco enables protein structural motif search in million scale databases.]]> Hyunbin KimRachel Seongeun KimMilot MirditaJaewon YoonMartin Steinegger doi:10.1038/s41587-026-03162-9 Nature Biotechnology, Published online: 2026-06-05; | doi:10.1038/s41587-026-03162-9 2026-06-05 Nature Biotechnology 10.1038/s41587-026-03162-9 https://www.nature.com/articles/s41587-026-03162-9 https://www.nature.com/articles/s41587-026-03182-5 Nature Biotechnology, Published online: 04 June 2026; doi:10.1038/s41587-026-03182-5

The significance of the first FDA-approved PROTAC lies not in proving that targeted protein degradation is superior to conventional therapies, but in proving that degrading proteins is possible as a therapeutic.]]> doi:10.1038/s41587-026-03182-5 Nature Biotechnology, Published online: 2026-06-04; | doi:10.1038/s41587-026-03182-5 2026-06-04 Nature Biotechnology 10.1038/s41587-026-03182-5 https://www.nature.com/articles/s41587-026-03182-5 https://www.nature.com/articles/s41587-026-03159-4 Nature Biotechnology, Published online: 03 June 2026; doi:10.1038/s41587-026-03159-4

The SONAR system enables RNA-level control of bacterial operons using a single engineered Cas13 effector that can be modified to control transcript degradation, translation inhibition and translation activation through simple changes in crRNA design.]]> doi:10.1038/s41587-026-03159-4 Nature Biotechnology, Published online: 2026-06-03; | doi:10.1038/s41587-026-03159-4 2026-06-03 Nature Biotechnology 10.1038/s41587-026-03159-4 https://www.nature.com/articles/s41587-026-03159-4 https://www.nature.com/articles/s41587-026-03152-x Nature Biotechnology, Published online: 03 June 2026; doi:10.1038/s41587-026-03152-x

Interactions between the tumor microenvironment and antibody drugs are imaged with spatial proteomics.]]> Guolan LuJohn W. HickeyMaximilian HaistXulei QinEmily ZhaoAbdullah NaveedErna ForgoMarc-A. BaertschLucas ManiXavier Rovira-ClavéAndrey FinegershYury GoltsevChiara CaraccioNynke S. van den BergMarisa HomDeana R. ColburgBrock A. MartinChristina S. KongNatalie S. LuiGeorge A. FisherA. Dimitrios ColevasRobert B. WestGreg M. ThurberGeorge A. PoultsidesGarry P. NolanEben L. Rosenthal doi:10.1038/s41587-026-03152-x Nature Biotechnology, Published online: 2026-06-03; | doi:10.1038/s41587-026-03152-x 2026-06-03 Nature Biotechnology 10.1038/s41587-026-03152-x https://www.nature.com/articles/s41587-026-03152-x https://www.nature.com/articles/s41587-026-03160-x Nature Biotechnology, Published online: 02 June 2026; doi:10.1038/s41587-026-03160-x

A Cas13-based gene switch allows multiplexed RNA regulation in bacteria.]]> Shengkun TongYuxi QinYaqian SunYaojie GaoMuyi SongTao FangYaojun Tong doi:10.1038/s41587-026-03160-x Nature Biotechnology, Published online: 2026-06-02; | doi:10.1038/s41587-026-03160-x 2026-06-02 Nature Biotechnology 10.1038/s41587-026-03160-x https://www.nature.com/articles/s41587-026-03160-x https://www.nature.com/articles/s41587-026-03161-w Nature Biotechnology, Published online: 01 June 2026; doi:10.1038/s41587-026-03161-w

This Perspective positions cellular self-organization as a foundational principle for the origin of multicellular life and discusses how decoding this concept with stem cell-based models will advance biological engineering.]]> Qi ChenMagdalena Zernicka-Goetz doi:10.1038/s41587-026-03161-w Nature Biotechnology, Published online: 2026-06-01; | doi:10.1038/s41587-026-03161-w 2026-06-01 Nature Biotechnology 10.1038/s41587-026-03161-w https://www.nature.com/articles/s41587-026-03161-w https://www.nature.com/articles/s41587-026-03142-z Nature Biotechnology, Published online: 01 June 2026; doi:10.1038/s41587-026-03142-z

Selection increases the purity of blood stem cells bearing targeted homologous recombination.]]> Daniele CanaruttoMartina FiumaraVigneshwaran VenkatesanChiara GaddoniKohei ShiroshitaAngelica VaresiLuisa AlbanoGabriele PelosiAlfredo SilvaClaudia FirritoGiulia SchiroliDeborah CipriaStefano BerettaAngelo AmabileAnna VillaErika ZonariBernhard GentnerAngelo LombardoPietro GenoveseSamuele FerrariLuigi Naldini doi:10.1038/s41587-026-03142-z Nature Biotechnology, Published online: 2026-06-01; | doi:10.1038/s41587-026-03142-z 2026-06-01 Nature Biotechnology 10.1038/s41587-026-03142-z https://www.nature.com/articles/s41587-026-03142-z