Nature Biotechnology is a monthly journal publishing new concepts in biological technology of relevance to bioengineering, medicine, energy, agriculture, food and the environment. It has a magazine covering the commercial, political, ethical, legal and societal aspects of this research. http://feeds.nature.com/nbt/rss/current Nature Publishing Group en © 2026 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. Nature Biotechnology © 2026 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. permissions@nature.com https://www.nature.com/uploads/product/nbt/rss.png http://feeds.nature.com/nbt/rss/current https://www.nature.com/articles/s41587-026-03138-9 Nature Biotechnology, Published online: 15 May 2026; doi:10.1038/s41587-026-03138-9

Cas12 nucleases can use guide DNA instead of guide RNA, which switches their targets from DNA to RNA.]]> Chase L. Beisel doi:10.1038/s41587-026-03138-9 Nature Biotechnology, Published online: 2026-05-15; | doi:10.1038/s41587-026-03138-9 2026-05-15 Nature Biotechnology 10.1038/s41587-026-03138-9 https://www.nature.com/articles/s41587-026-03138-9 https://www.nature.com/articles/s41587-026-03129-w Nature Biotechnology, Published online: 15 May 2026; doi:10.1038/s41587-026-03129-w

ΨDNA guides are used with Cas12 for precise, programmable targeting of cellular RNA.]]> Carlos OroscoBoyu HuangSantosh R. RananawareAugust P. BodinIvy BrowningAnne FangMichael P. BaughIan H. LangeYasmin B. ElhabashyMahika BalarajuJordan G. LewisNayan H. ShahMichael P. HannaSarah J. FlanneryKatelyn S. MeisterVedant KaralkarPiyush K. Jain doi:10.1038/s41587-026-03129-w Nature Biotechnology, Published online: 2026-05-15; | doi:10.1038/s41587-026-03129-w 2026-05-15 Nature Biotechnology 10.1038/s41587-026-03129-w https://www.nature.com/articles/s41587-026-03129-w https://www.nature.com/articles/s41587-026-03130-3 Nature Biotechnology, Published online: 15 May 2026; doi:10.1038/s41587-026-03130-3

Many long noncoding RNA–DNA binding peaks detected using common assays arise from technical artifacts.]]> Micah Jonathan GoldrichLouis DelhayeSarah-Lee BekaertBieke DecaestekerFilip Van NieuwerburghFrank SpelemanSven EyckermanPieter MestdaghIgor Ulitsky doi:10.1038/s41587-026-03130-3 Nature Biotechnology, Published online: 2026-05-15; | doi:10.1038/s41587-026-03130-3 2026-05-15 Nature Biotechnology 10.1038/s41587-026-03130-3 https://www.nature.com/articles/s41587-026-03130-3 https://www.nature.com/articles/s41587-026-03115-2 Nature Biotechnology, Published online: 13 May 2026; doi:10.1038/s41587-026-03115-2

Immune-remodeling mRNAs delivered in lipid nanoparticles boost antitumor immunity.]]> A. GuptaR. DasK. ReedT. JeonQ. T. C. NguyenA. RudraX. GeS. TrongjitY. S. VanrobaeysR. LangerR. WeisslederC. GarrisD. G. Anderson doi:10.1038/s41587-026-03115-2 Nature Biotechnology, Published online: 2026-05-13; | doi:10.1038/s41587-026-03115-2 2026-05-13 Nature Biotechnology 10.1038/s41587-026-03115-2 https://www.nature.com/articles/s41587-026-03115-2 https://www.nature.com/articles/s41587-026-03128-x Nature Biotechnology, Published online: 13 May 2026; doi:10.1038/s41587-026-03128-x

A deep-learning method predicts T cell receptor specificity and disease-associated antigens.]]> Nan WangHugh YehBen LaiJason PereraKevin M. JudeIsabel RischJoy UmXiaojing ChenXinyu XiangChunyu WangLiu Daisy LiuXinbo YangMichael A. PaleyAly A. KhanK. Christopher Garcia doi:10.1038/s41587-026-03128-x Nature Biotechnology, Published online: 2026-05-13; | doi:10.1038/s41587-026-03128-x 2026-05-13 Nature Biotechnology 10.1038/s41587-026-03128-x https://www.nature.com/articles/s41587-026-03128-x https://www.nature.com/articles/s41587-026-03155-8 Nature Biotechnology, Published online: 11 May 2026; doi:10.1038/s41587-026-03155-8

While circRNA is often framed as a more stable, longer-lasting alternative to linear mRNA, its real-world advantages remain largely theoretical, and it is unclear whether greater molecular stability will translate into meaningful clinical gains.]]> doi:10.1038/s41587-026-03155-8 Nature Biotechnology, Published online: 2026-05-11; | doi:10.1038/s41587-026-03155-8 2026-05-11 Nature Biotechnology 10.1038/s41587-026-03155-8 https://www.nature.com/articles/s41587-026-03155-8 https://www.nature.com/articles/s41587-026-03136-x Nature Biotechnology, Published online: 07 May 2026; doi:10.1038/s41587-026-03136-x

AstraZeneca’s IL-33 antibody tozorakimab targets two distinct signaling pathways engaged in COPD: inflammation and epithelial dysfunction.]]> Charlotte Harrison doi:10.1038/s41587-026-03136-x Nature Biotechnology, Published online: 2026-05-07; | doi:10.1038/s41587-026-03136-x 2026-05-07 Nature Biotechnology 10.1038/s41587-026-03136-x https://www.nature.com/articles/s41587-026-03136-x https://www.nature.com/articles/s41587-026-03141-0 Nature Biotechnology, Published online: 05 May 2026; doi:10.1038/s41587-026-03141-0

We developed PIVOT, a single-cell screening platform for functional characterization of plant genes. PIVOT enables delivery of gene libraries to tobacco leaves with single multiplicity of infection and magnetic sorting of single plant cells by phenotype. We use PIVOT to recover regulators of cytokinin signaling from an Arabidopsis open reading frame library.]]> doi:10.1038/s41587-026-03141-0 Nature Biotechnology, Published online: 2026-05-05; | doi:10.1038/s41587-026-03141-0 2026-05-05 Nature Biotechnology 10.1038/s41587-026-03141-0 https://www.nature.com/articles/s41587-026-03141-0