Nature Genetics is the primary research journal for the genetics community. With a reputation for quality global coverage, Nature Genetics delivers the latest research across the field, including human genetics and genomics, genomics in plant and animal breeding, epigenetics, cancer and genetic technology. With News and Views, Analysis, Perspectives, Letters, Articles and Technical Reports, Nature Genetics is consistently the most frequently cited primary research journal in the field of Genetics and Heredity. http://feeds.nature.com/ng/rss/current Nature Publishing Group en © 2026 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. Nature Genetics © 2026 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. permissions@nature.com https://www.nature.com/uploads/product/ng/rss.png http://feeds.nature.com/ng/rss/current https://www.nature.com/articles/s41588-026-02604-z Nature Genetics, Published online: 20 May 2026; doi:10.1038/s41588-026-02604-z

Davidovich et al. investigate allele-specific DNA methylation inheritance patterns in mouse liver and muscle. Most patterns are Mendelian, but ~7% are non-Mendelian, including new imprinted genes and a paramutation at the Capn11 locus.]]> Adam DavidovichDanila CuomoHang SuSandeep KambhampatiQingqing GongAlexandra NaronRakel TryggvadottirLeonard McMillanKasper D. HansenDavid W. ThreadgillAndrew P. Feinberg doi:10.1038/s41588-026-02604-z Nature Genetics, Published online: 2026-05-20; | doi:10.1038/s41588-026-02604-z 2026-05-20 Nature Genetics 10.1038/s41588-026-02604-z https://www.nature.com/articles/s41588-026-02604-z https://www.nature.com/articles/s41588-026-02612-z Nature Genetics, Published online: 20 May 2026; doi:10.1038/s41588-026-02612-z

This study identifies structural variants (SVs) from long-read assemblies, develops a new reference panel and web application to impute SVs from single-nucleotide polymorphism-level data, and identifies associations between SVs and complex traits.]]> Wei-Yang BaiShuli LiuZhongqu DuanJi-Jian YangJie ChenJunren HouLianfeng WuNan LiTing QiJian Yang doi:10.1038/s41588-026-02612-z Nature Genetics, Published online: 2026-05-20; | doi:10.1038/s41588-026-02612-z 2026-05-20 Nature Genetics 10.1038/s41588-026-02612-z https://www.nature.com/articles/s41588-026-02612-z https://www.nature.com/articles/s41588-026-02610-1 Nature Genetics, Published online: 20 May 2026; doi:10.1038/s41588-026-02610-1

Cellist is a computationally efficient cell-segmentation method combining imaging and expression data from spatial transcriptomics across different technologies.]]> Dongqing SunLele ZhangTong HanQiu WuPeng ZhangChenfei Wang doi:10.1038/s41588-026-02610-1 Nature Genetics, Published online: 2026-05-20; | doi:10.1038/s41588-026-02610-1 2026-05-20 Nature Genetics 10.1038/s41588-026-02610-1 https://www.nature.com/articles/s41588-026-02610-1 https://www.nature.com/articles/s41588-026-02606-x Nature Genetics, Published online: 19 May 2026; doi:10.1038/s41588-026-02606-x

Large-scale biological data repositories, particularly when deployed as single, non-mirrored instances or governed within narrow contexts, face structural vulnerabilities, from cyberattacks to funding disruptions. We propose a hybrid framework that integrates federated and decentralized models to ensure the resilience, sustainability and FAIR/CARE stewardship of scientific data as a global public good.]]> Gaurav SharmaViorel MunteanuNika Mansouri GhiasiUtkarsha MahantaJineta BanerjeeSusheel VarmaLuca FoschiniKyle EllrottOnur MutluDumitru CiorbăRoel A. OphoffViorel BostanJason H. MooreDespoina SousoniArunkumar KrishnanAlexander G. LucaciAlba TullChristopher E. MasonMihai DimianGustavo StolovitzkyFabio G. LiberanteTaras K. OleksykSerghei Mangul doi:10.1038/s41588-026-02606-x Nature Genetics, Published online: 2026-05-19; | doi:10.1038/s41588-026-02606-x 2026-05-19 Nature Genetics 10.1038/s41588-026-02606-x https://www.nature.com/articles/s41588-026-02606-x https://www.nature.com/articles/s41588-026-02596-w Nature Genetics, Published online: 19 May 2026; doi:10.1038/s41588-026-02596-w

A de novo genome assembly of drought-resistant wheat (Triticum aestivum L.) genotype JIN50 and genomic analyses across other wheat germplasms identify structural variations contributing to drought responses and adaptation.]]> Jingchen LinChenji ZhangZehui LiuJinpeng LiQun YangWei ChuDebiao LiuLei ZhangDanyang ZhaoXiao PengWanghongan JiaHuitao AnMingming XinYingyin YaoWeilong GuoHuiru PengChaojie XieZhongfu NiQixin SunZhaorong Hu doi:10.1038/s41588-026-02596-w Nature Genetics, Published online: 2026-05-19; | doi:10.1038/s41588-026-02596-w 2026-05-19 Nature Genetics 10.1038/s41588-026-02596-w https://www.nature.com/articles/s41588-026-02596-w https://www.nature.com/articles/s41588-026-02592-0 Nature Genetics, Published online: 19 May 2026; doi:10.1038/s41588-026-02592-0

High-resolution analyses of blood-derived whole-genome sequence data from UK Biobank detect new mosaic chromosomal alterations and identify rare protein-coding variants associated with clonal expansions of copy-neutral loss-of-heterozygosity mutations.]]> David TangNolan KamitakiRonen E. MukamelSimone RubinacciPo-Ru Loh doi:10.1038/s41588-026-02592-0 Nature Genetics, Published online: 2026-05-19; | doi:10.1038/s41588-026-02592-0 2026-05-19 Nature Genetics 10.1038/s41588-026-02592-0 https://www.nature.com/articles/s41588-026-02592-0 https://www.nature.com/articles/s41588-026-02636-5 Nature Genetics, Published online: 18 May 2026; doi:10.1038/s41588-026-02636-5

Author Correction: Biallelic variants in the noncoding RNA gene RNU4-2 cause a recessive neurodevelopmental syndrome with distinct white matter changes]]> RNU4-2 cause a recessive neurodevelopmental syndrome with distinct white matter changes]]> Rocio RiusAlexander J. M. BlakesYuyang ChenJoachim De JongheFrançois LecoquierreRuebena DawesBenjamin CogneHyung Chul KimJaveria R. AlviFlorence AmblardMorad AnsariAnnabelle ArltChristina Austin-TseSarah BaerMeena BalasubramanianElsa V. BaltonGiulia BarciaAna Beleza-MeirelesJonathan A. BernsteinJasmin BeygoPierre BlancNuria C. BramswigFrederik BraunDaniel BuchzikDaniel G. CalameJamie CampbellCharles CouttonChloe A. CunninghamNitsuh DargieChristel DepienneKatrina M. DippleAnne DieuxAbhijit DixitLauren DreyerHaowei DuSalima El ChehadehMichael FieldLisa J. EwansVanessa GeigerRichard A. GibbsIan GlassOlivier GrunewaldPaul GueguenTobias B. HaackHamza Hadj AbdallahRadu HarbuzIngo HelbigJudit HorvathAlexander HustinxBertrand IsidorMarie-Line JacquemontFraser JamieMédéric JeanneRiley KesslerHannah KlinkhammerG. Christoph KorenkeUrania KotzaeridouPeter KrawitzSteven LaurieRichard J. LeventerRebecca J. LevyJames R. LupskiPierre MarijonKaitlin E. McGinnisRodrigo MendezOlfa MessaoudCaroline NavaMevyn NizardAnne O’Donnell-LuriaMelanie C. O’LearySimone OlivieriAmitav ParidaDavut PehlivanAnna Jenne PrenticeJennifer E. PoseyChloe M. ReuterVéronique SatreCaroline Schluth-BolardThomas SmolTipu SultanJohn TaylorChristel Thauvin-RobinetJulien ThevenonEloise UebergangSandra UeberbergCatherine Vincent-DelormeEvangeline WassmerEmma WestwoodMatthew T. WheelerElif Yilmaz GulecAdeline VanderverArastoo VossoughStephan J. SandersSiddharth BankaGregory M. FindlayDaniel G. MacArthurCas SimonsNicola Whiffin doi:10.1038/s41588-026-02636-5 Nature Genetics, Published online: 2026-05-18; | doi:10.1038/s41588-026-02636-5 2026-05-18 Nature Genetics 10.1038/s41588-026-02636-5 https://www.nature.com/articles/s41588-026-02636-5 https://www.nature.com/articles/s41588-026-02586-y Nature Genetics, Published online: 18 May 2026; doi:10.1038/s41588-026-02586-y

Restricting or permitting H3K27me3 spreading concentrates or dilutes canonical PRC1 (cPRC1), respectively, which affects three-dimensional chromatin interactions. Disruption of cPRC1 compromises repression of Polycomb target genes and induces differentiation and tumor regression in H3K27M-mutant glioma.]]> Brian KrugBo HuHaifen ChenClaudia Negrón-LomasXiao ChenAhmed El MouataniKristjan H. GretarssonAdam PtackShriya DeshmukhNisha KabirWajih JawharAugusto Faria AndradeElias JabbourAshot S. HarutyunyanXinrui WangRobert TaylorJohn J. Y. LeeMaud HulswitDamien FauryCaterina RussoXinjing XuJiahan YangAudrey BaguetteNathan A. DahlAlexander G. WeilBenjamin EllezamRola DaliMathieu BlanchetteKhadija WilsonBenjamin A. GarciaRajesh Kumar SoniMarco GalloMichael D. TaylorClaudia L. KleinmanJacek MajewskiNada JabadoChao Lu doi:10.1038/s41588-026-02586-y Nature Genetics, Published online: 2026-05-18; | doi:10.1038/s41588-026-02586-y 2026-05-18 Nature Genetics 10.1038/s41588-026-02586-y https://www.nature.com/articles/s41588-026-02586-y