Nature Genetics

Linking GWAS risk genes to transcriptional features of major depressive disorder via in vivo Perturb-seq

Liansheng Zhang — 2026-06-10

Nature Genetics, Published online: 10 June 2026; doi:10.1038/s41588-026-02638-3

The authors optimize and apply in vivo AAV-Perturb-seq to systematically profile GWAS-linked major depressive disorder risk genes and their corresponding transcriptomic features in the mouse brain.

CytoSignal detects locations and dynamics of ligand–receptor signaling at cellular resolution from spatial transcriptomic data

Jialin Liu — 2026-06-10

Nature Genetics, Published online: 10 June 2026; doi:10.1038/s41588-026-02624-9

CytoSignal models ligand–receptor interactions at cellular resolution using spatial transcriptomic data, inferring interaction scores at each spatial position and predicting temporal dynamics by incorporating RNA velocity.

Pleiotropic shared heritability quantifies the shared genetic variance of common diseases

Yujie Zhao — 2026-06-09

Nature Genetics, Published online: 09 June 2026; doi:10.1038/s41588-026-02607-w

Pleiotropic shared heritability with bias correction (PHBC) estimates the genetic variance of a target disease that is shared with a set of auxiliary diseases. Applying PHBC to diseases in the UK Biobank shows pervasive sharing of genetic etiologies across disease categories.

Inflammatory cytokines induce new cancer dependencies

Collins K. Cheruiyot — 2026-06-09

Nature Genetics, Published online: 09 June 2026; doi:10.1038/s41588-026-02614-x

Cheruiyot et al. conduct genome-scale in vitro CRISPR loss-of-function screens to map genetic vulnerabilities induced by inflammatory cytokines and identify the glycosylphosphatidylinositol transamidase complex and the lipid phosphatase FITM2 as two interferon-specific tumor dependencies whose disruption sensitizes tumors to immune checkpoint blockade.

Spatially resolved single-cell analyses of human meningioma identify novel cell states influencing tumor microenvironment and progression

Alexander P. Landry — 2026-06-09

Nature Genetics, Published online: 09 June 2026; doi:10.1038/s41588-026-02615-w

This paper presents a sizeable single-cell multi-omic analysis of meningiomas comprising more than seven million cells. The results highlight tumor-intrinsic heterogeneity within both malignant and stromal compartments.

MIXPRS enables multi-population and multi-method polygenic risk scores using summary statistics

Leqi Xu — 2026-06-09

Nature Genetics, Published online: 09 June 2026; doi:10.1038/s41588-026-02637-4

MIXPRS is a framework for combining polygenic risk scores from multiple populations using GWAS summary statistics, enabling risk scores that can be effective for individuals across ancestries.

Genomic analysis of 3,330 accessions provides insights into the evolutionary history and self-incompatibility locus of the Brassica A genome

Xu Cai — 2026-06-08

Nature Genetics, Published online: 08 June 2026; doi:10.1038/s41588-026-02626-7

Pan-genomic analyses shed light on the evolutionary history of the Brassica A subgenome and identify a unique barcode pattern of transposable elements that underpin the Brassica self-incompatibility system.

The promise of adaptive health in the United Arab Emirates and beyond

Andrew P. Feinberg — 2026-06-03

Nature Genetics, Published online: 03 June 2026; doi:10.1038/s41588-026-02630-x

Leveraging a national-scale long-read sequencing program and new methods for allele-specific epigenome analysis, the integrated health ecosystem of the United Arab Emirates has created a unique platform in which genomic, clinical and environmental insights can converge to enable adaptive, preventive healthcare.