Nature Genetics is the primary research journal for the genetics community. With a reputation for quality global coverage, Nature Genetics delivers the latest research across the field, including human genetics and genomics, genomics in plant and animal breeding, epigenetics, cancer and genetic technology. With News and Views, Analysis, Perspectives, Letters, Articles and Technical Reports, Nature Genetics is consistently the most frequently cited primary research journal in the field of Genetics and Heredity. http://feeds.nature.com/ng/rss/current Nature Publishing Group en © 2026 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. Nature Genetics © 2026 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. permissions@nature.com https://www.nature.com/uploads/product/ng/rss.png http://feeds.nature.com/ng/rss/current https://www.nature.com/articles/s41588-026-02619-6 Nature Genetics, Published online: 15 June 2026; doi:10.1038/s41588-026-02619-6

This study contributes a resource of predicted effects of noncoding variants on chromatin accessibility and a method to identify noncoding variants with extreme regulatory effects, with application to disease variant discovery.]]> Andrew R. MardersteinSoumya KunduEvin M. PadhiSalil DeshpandeAustin WangEsther RobbYing SunChang M. YunDiego Pomales-MatosYilin XieSerena H. ChangIris M. ChinAayushi J. ShahZachary A. GardellM. Ryan CorcesDaniel NachunSelin JessaAnshul KundajeStephen B. Montgomery doi:10.1038/s41588-026-02619-6 Nature Genetics, Published online: 2026-06-15; | doi:10.1038/s41588-026-02619-6 2026-06-15 Nature Genetics 10.1038/s41588-026-02619-6 https://www.nature.com/articles/s41588-026-02619-6 https://www.nature.com/articles/s41588-026-02634-7 Nature Genetics, Published online: 15 June 2026; doi:10.1038/s41588-026-02634-7

IBDverse is a single-cell RNA atlas of terminal ileal biopsies comprising 1.1 million cells from 111 patients with Crohn’s disease and 232 healthy participants. Analysis of the data identifies genes, pathways and cell populations associated with the disease and implicates inflammatory monocytes and macrophages in disease susceptibility.]]> Monika KrzakTobi AlegbeD. Leland TaylorGareth-Rhys JonesMennatallah GhourabaMichelle StricklandBradley T. HarrisReem SattiKenneth ArestangLucia Ramirez-NavarroNilanga NishadKimberly Ai Xian CheamMarcus TutertMatiss OzolsGuillaume NoellSteven LeonardMoritz J. PrzybillaCiro Ramirez SuasteguiEleonora KhabirovaTong DengHanna NajgebauerVelislava PetrovaCarla P. JonesNoor WanaMay Xueqi HuJason SkeltonJasmin OstermayerYong GuWendy GarriBiljana BrezinaCharry Queen CaballesDaniele CorridoniMiles ParkesVivek IyerCristina Cotobal MartinRebecca E. McIntyreTim RaineCarl A. Anderson doi:10.1038/s41588-026-02634-7 Nature Genetics, Published online: 2026-06-15; | doi:10.1038/s41588-026-02634-7 2026-06-15 Nature Genetics 10.1038/s41588-026-02634-7 https://www.nature.com/articles/s41588-026-02634-7 https://www.nature.com/articles/s41588-026-02651-6 Nature Genetics, Published online: 12 June 2026; doi:10.1038/s41588-026-02651-6

Mitochondrial capsules mitigate mitochondrial dysfunction]]> Chiara Anania doi:10.1038/s41588-026-02651-6 Nature Genetics, Published online: 2026-06-12; | doi:10.1038/s41588-026-02651-6 2026-06-12 Nature Genetics 10.1038/s41588-026-02651-6 https://www.nature.com/articles/s41588-026-02651-6 https://www.nature.com/articles/s41588-026-02652-5 Nature Genetics, Published online: 12 June 2026; doi:10.1038/s41588-026-02652-5

Dynamic genetic effects on lifespan]]> Margot Brandt doi:10.1038/s41588-026-02652-5 Nature Genetics, Published online: 2026-06-12; | doi:10.1038/s41588-026-02652-5 2026-06-12 Nature Genetics 10.1038/s41588-026-02652-5 https://www.nature.com/articles/s41588-026-02652-5 https://www.nature.com/articles/s41588-026-02650-7 Nature Genetics, Published online: 12 June 2026; doi:10.1038/s41588-026-02650-7

Proteomic prediction of APOL1-associated kidney disease]]> APOL1-associated kidney disease]]> Kyle Vogan doi:10.1038/s41588-026-02650-7 Nature Genetics, Published online: 2026-06-12; | doi:10.1038/s41588-026-02650-7 2026-06-12 Nature Genetics 10.1038/s41588-026-02650-7 https://www.nature.com/articles/s41588-026-02650-7 https://www.nature.com/articles/s41588-026-02653-4 Nature Genetics, Published online: 12 June 2026; doi:10.1038/s41588-026-02653-4

Somatic mutations in autoimmunity]]> Safia Danovi doi:10.1038/s41588-026-02653-4 Nature Genetics, Published online: 2026-06-12; | doi:10.1038/s41588-026-02653-4 2026-06-12 Nature Genetics 10.1038/s41588-026-02653-4 https://www.nature.com/articles/s41588-026-02653-4 https://www.nature.com/articles/s41588-026-02616-9 Nature Genetics, Published online: 12 June 2026; doi:10.1038/s41588-026-02616-9

This study implicates recurrent in-frame deletions in COPA exon 13 in small intestinal tumorigenesis through activation of Wnt signaling in an R-spondin-independent but Wnt ligand-dependent manner.]]> COPA mutation drives R-spondin-independent Wnt activation in intestinal tumors]]> Masayuki FujiiNaoko AbetoShotaro KishimotoKouya ShiraishiTaiki HashimotoNobuyoshi HiraokaSatoru NonakaMotohiro KojimaMami MatanoSirirat TakahashiGabriele ColozzaBon-Kyoung KooYasushi YatabeMotohiko KatoToshiro SatoShigeki Sekine doi:10.1038/s41588-026-02616-9 Nature Genetics, Published online: 2026-06-12; | doi:10.1038/s41588-026-02616-9 2026-06-12 Nature Genetics 10.1038/s41588-026-02616-9 https://www.nature.com/articles/s41588-026-02616-9 https://www.nature.com/articles/s41588-026-02633-8 Nature Genetics, Published online: 12 June 2026; doi:10.1038/s41588-026-02633-8

This study investigates the consequences of hypermethylation in a progeria syndrome caused by gain-of-function DNMT3A mutations, finding effects on adult stem cell function.]]> Dan SarniGráinne NearyPaula L. CarrollChris S. VinkCaroline V. BillardTomoya IsobeXiong WengJordan R. PortmanDaniel L. McCartneyPatricia HeynRob J. van ‘t HofLinda R. MorrisonCarol-Anne MartinColin StokMargaret E. HarleyAndrea LeitchMaarten van den AnckerNic RobertsonLaura KittoRichard ClarkMichael RennieAnna PopravkoJessica J. McClureDavid A. ParryGiuseppina CamioloTom LeahHélène JakobczykRoly MegawLisa McKieGrant F. MarshallNika BalkicJeanne AmielTania Barragán ArévaloGrace Bronken McCarthyCatherine A. BuchananAlexandre BuffetAlberto CascónBenjamin CogneSolene ConradAnna Maria Cueto-GonzálezMaria Currás-FreixesGunnar Douzgos HougeChin-To FongJaya K. George-AbrahamKate GibsonLourdes IbáñezNicola LongoCharlotte Lussey-LepoutreBradley S. MillerAlejandro Moles-FernandezNishitha R. PillaiTatiana TvrdikMarie VincentEmiy YokoyamaCatherine M. AbbottFrancisco Jose Sanchez-LuqueKatrin OttersbachCosimo De BariAnke J. RoelofsRebekah TillotsonKamil R. KrancSara J. BrownRiccardo E. MarioniMihaela CrisanBerthold GöttgensNeil C. HendersonRobert K. SempleKevin B. MyantElaine DzierzakMartin A. M. ReijnsDuncan SproulAndrew P. Jackson doi:10.1038/s41588-026-02633-8 Nature Genetics, Published online: 2026-06-12; | doi:10.1038/s41588-026-02633-8 2026-06-12 Nature Genetics 10.1038/s41588-026-02633-8 https://www.nature.com/articles/s41588-026-02633-8