Nature Genetics is the primary research journal for the genetics community. With a reputation for quality global coverage, Nature Genetics delivers the latest research across the field, including human genetics and genomics, genomics in plant and animal breeding, epigenetics, cancer and genetic technology. With News and Views, Analysis, Perspectives, Letters, Articles and Technical Reports, Nature Genetics is consistently the most frequently cited primary research journal in the field of Genetics and Heredity. http://feeds.nature.com/ng/rss/current Nature Publishing Group en © 2026 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. Nature Genetics © 2026 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. permissions@nature.com https://www.nature.com/uploads/product/ng/rss.png http://feeds.nature.com/ng/rss/current https://www.nature.com/articles/s41588-026-02626-7 Nature Genetics, Published online: 08 June 2026; doi:10.1038/s41588-026-02626-7

Pan-genomic analyses shed light on the evolutionary history of the Brassica A subgenome and identify a unique barcode pattern of transposable elements that underpin the Brassica self-incompatibility system.]]> Brassica A genome]]> Xu CaiZhicheng ZhangLupeng ZhangFengming LiYufang LiHaixu ChenLichun ChangTingting ZhangJianli LiangXiaowu WangJian Wu doi:10.1038/s41588-026-02626-7 Nature Genetics, Published online: 2026-06-08; | doi:10.1038/s41588-026-02626-7 2026-06-08 Nature Genetics 10.1038/s41588-026-02626-7 https://www.nature.com/articles/s41588-026-02626-7 https://www.nature.com/articles/s41588-026-02630-x Nature Genetics, Published online: 03 June 2026; doi:10.1038/s41588-026-02630-x

Leveraging a national-scale long-read sequencing program and new methods for allele-specific epigenome analysis, the integrated health ecosystem of the United Arab Emirates has created a unique platform in which genomic, clinical and environmental insights can converge to enable adaptive, preventive healthcare.]]> Andrew P. FeinbergEduardo BeltrameMohamed AlameriEran SegalShahrukh HashmiDavid Threadgill doi:10.1038/s41588-026-02630-x Nature Genetics, Published online: 2026-06-03; | doi:10.1038/s41588-026-02630-x 2026-06-03 Nature Genetics 10.1038/s41588-026-02630-x https://www.nature.com/articles/s41588-026-02630-x https://www.nature.com/articles/s41588-026-02583-1 Nature Genetics, Published online: 03 June 2026; doi:10.1038/s41588-026-02583-1

An updated meta-analysis of genome-wide association studies identified 91 risk loci for Alzheimer’s disease (AD) and related dementias among individuals of European ancestry, of which 56 loci were specifically detected in clinically diagnosed AD cases.]]> Céline BellenguezAtahualpa Castillo MoralesNajaf AminSven J. van der LeeManon MuntanerKayenat ParveenFahri KüçükaliBenjamin Grenier-BoleySami HeikkinenItziar de RojasMaria Carolina DalmassoLuca KleineidamOliver PetersAnja SchneiderMartin DichgansDan RujescuNorbert ScherbaumJürgen DeckertSteffi Riedel-HellerLucrezia HausnerLaura Molina-PorcelEmrah DüzelTimo GrimmerJens WiltfangStefanie Heilmann-HeimbachSusanne MoebusMatthias SchmidThomas TegosNikolaos ScarmeasOriol Dols-IcardoFermin MorenoJordi Pérez-TurMaría J. BullidoPau PastorRaquel Sánchez-ValleVictoria ÁlvarezMercè BoadaPablo García-GonzálezRaquel PuertaPablo MirLuis M. RealGerard Piñol-RipollJose María García-AlbercaEloy Rodriguez-RodriguezHilkka SoininenAlexandre de MendonçaShima MehrabianJakub HortMartin VyhnalekNicolai SandauJiao LuoJesper Qvist ThomassenYolande A. L. PijnenburgWiesje van der FlierHarro SeelaarInez RamakersJanne PapmaMarc HulsmanGert-Jan BiesselsCaroline GraffHakan ThonbergAbbe UllgrenGoran PapenbergVilmantas GiedraitisMalin LöwenmarkLena KilanderJulie WilliamsPeter HolmansJulie Le BorgneSagnik PalmalAude NicolasPhilippe AmouyelAnne BolandJean-François DeleuzeGael NicolasCarole DufouilFlorence PasquierOlivier HanonStéphanie DebetteEdna GrünblattJulius PoppDaniela GalimbertiBeatrice ArosioPatrizia MecocciVincenzo SolfrizziLucilla ParnettiAlessio SquassinaLucio TremolizzoBarbara BorroniMichael WagnerBenedetta NacmiasMarco SpallazziDavide SeripaInnocenzo RaineroAntonio DanielePaola BossùCarlo MasulloGiacomina RossiFrank JessenHenne HolstegeKaren MatherM. Victoria FernandezPatrick G. KehoeMagda TsolakiCornelia van DuijnRuth Frikke-SchmidtRoberta GhidoniPascual Sánchez-JuanKristel SleegersMartin IngelssonMikko HiltunenRebecca SimsOle AndreassenAgustín RuizAlfredo RamirezJean-Charles LambertAdam C. NajFarid RajabliPenelope BenchekLincoln M. P. ShadeQi QiaoNicholas KushchJin ShaKatrina BazemoreCongcong ZhuWan-Ping LeeJacob HautKara L. Hamilton-NelsonNicholas R. WheelerYi ZhaoJohn J. FarrellMichelle A. GruninYuk Yee LeungPavel P. KuksaDonghe LiEder Lucio da FonsecaJesse B. MezEllen L. PalmerJagan PillaiRichard M. ShervaYeunjoo E. SongXiaoling ZhangTakeshi IkeuchiTaha IqbalOtto ValladaresDolly Reyes-DumeyerAmanda B. KuzmaErin AbnerLarry D. AdamsAlyssa AguirreMarilyn S. AlbertRoger L. AlbinMariet AllenLiana G. ApostolovaSteven E. ArnoldSanjay AsthanaCraig S. AtwoodSanford AuerbachClinton T. BaldwinRobert C. BarberLisa L. BarnesSandra BarralThomas G. BeachJames T. BeckerGary W. BeechamDuane BeeklyDavid A. BennettJohn BertelsonThomas D. BirdDeborah BlackerBradley F. BoeveJames D. BowenAdam BoxerJames BrewerJeffrey M. BurnsJoseph D. BuxbaumNigel J. CairnsLaura B. CantwellChuanhai CaoChristopher S. CarlsonCynthia M. CarlssonRegina M. CarneyMinerva M. CarrasquilloMarie-Francoise ChesseletNathaniel A. ChinHelena C. ChuiJaeyoon ChungSteven A. ClaasSuzanne CraftPaul K. CraneDavid H. CribbsElizabeth A. CroccoCarlos CruchagaMichael L. CuccaroMunro CullumEveleen DarbyBarbara DavisPhilip L. De JagerCharles DeCarliJohn DeToledoMalcolm DickDennis W. DicksonBeth A. DombroskiRachelle S. DoodyRanjan DuaraLogan C. DumitrescuNilüfer Ertekin-TanerDenis A. EvansKelley M. FaberThomas J. FairchildKenneth B. FallonMartin R. FarlowVictoria Fernandez-HernandezRobert P. FriedlandTatiana M. ForoudMatthew P. FroschBrian Fulton-HowardDouglas R. GalaskoMarla GearingDaniel H. GeschwindBernardino GhettiJohn R. GilbertRodney C. P. GoAlison M. GoateThomas J. GrabowskiNeill R. Graff-RadfordNora E. GrayJohn H. GrowdonHakon HakonarsonJames HallRonald L. HamiltonOscar HarariJohn HardyElizabeth HeadVictor W. HendersonMichelle HernandezTimothy J. HohmanLawrence S. HonigRyan M. HuebingerMatthew J. HuentelmanBradley T. HymanLinda S. HynanLaura IbanezGail P. JarvikSuman JayadevLee-Way JinKim JohnsonLeigh JohnsonM. Ilyas KambohYuriko KatsumataMindy J. KatzJohn S. KauweJeffrey A. KayeC. Dirk KeeneAisha KhaleeqMasataka KikuchiJanice KneblNeil W. KowallJoel H. KramerWalter A. KukullFrank M. LaFerlaJames J. LahEric B. LarsonAlan LernerJames B. LeverenzAllan I. LeveyAndrew P. LiebermanRichard B. LiptonMark LogueOscar L. LopezKathryn L. LunettaConstantine G. LyketsosDouglas MainsDaniel C. MarsonEden R. R. MartinFrank MartiniukDeborah C. MashEliezer MasliahPaul MassmanArjun MasurkarWayne C. McCormickSusan M. McCurryAnn C. McKeeMarsel MesulamBruce L. MillerCarol A. MillerJoshua W. MillerThomas J. MontineEdwin S. MonukiJohn C. MorrisShubhabrata MukherjeeAmanda J. MyersTrung NguyenThomas ObisesanSid O’BryantJohn M. OlichneyRaymond PalmerJoseph E. ParisiHenry L. PaulsonValory PavlikDavid PaydarfarVictoria PerezElaine PeskindRonald C. PetersenHelen PetrovitchMarsha PolkWayne W. PoonHuntington PotterLiming QuMary QuicenoJoseph F. QuinnAshok RajMurray RaskindEric M. ReimanBarry ReisbergJoan S. ReischJohn M. RingmanErik D. RobersonMonica RodriguearEkaterina RogaevaHoward J. RosenRoger N. RosenbergDonald R. RoyallMarwan SabbaghA. Dessa SadovnickMark A. SagerMary SanoAndrew J. SaykinJulie A. SchneiderLon S. SchneiderWilliam W. SeeleySusan H. SliferScott SmallAmanda G. SmithJoshua A. SonnenPeter St George-HyslopTakiyah D. StarksRobert A. SternAlan B. StevensStephen M. StrittmatterDavid SultzerRussell H. SwerdlowRudolph E. TanziJeffrey L. TilsonJuan C. TroncosoDebby W. TsuangVivianna M. Van DeerlinLinda J. Van EldikJeffery M. VanceBadri N. VardarajanRobert VassarHarry V. VintersJean-Paul VonsattelSandra WeintraubKathleen A. Welsh-BohmerPatrice L. WhiteheadEllen M. WijsmanKirk C. WilhelmsenBenjamin WilliamsJennifer WilliamsonHenrik WilmsThomas S. WingoThomas WisniewskiRandall L. WoltjerClinton B. WrightChuang-Kuo WuSteven G. YounkinChang-En YuLei YuXiongwei ZhuBrian W. KunkleWilliam S. BushAkinori MiyashitaGiuseppe TostoGyungah R. JunChristiane ReitzGoldie S. ByrdDavid W. FardoLi-San WangLindsay A. FarrerJonathan L. HainesRichard MayeuxMargaret A. Pericak-VanceGerard D. SchellenbergBernard FongangAmber YaqubMuralidharan SargurupremrajXueqiu JianAniket MishraJoshua C. BisMonica Gireud-GossJayandra Jung HimaliHabil ZareVilmundur GuðnasonLenore LaunerJan BresslerHans J. GrabeM. Arfan IkramBruce M. PsatyW. T. LongstrethSigurdur SigurdssonMohsen GhanbariFranck J. WoltersEric BoerwinkleAlexa S. BeiserChloe SarnowskiThomas H. MosleyOscar L. LopezCornelia van DuijnClaudia SatizabalM. Kamran IkramYang QiongMyriam FornageSudha SeshadriRebecca MahoneyNicola DenningAlun MeggyRachel MarshallDanielle LeRouxCatherine BresnerValentina Escott-PriceKevin MorganKeeley BrookesTamar Guetta-BaranesClive HolmesGill WindleVanessa BurholtEmma GreenCatherine MacleodBob WoodsSimon MeadJonathan M. SchottNick FoxSeth LoveClàudia OlivéLaura MontrrealM. Victoria FernándezMarta MarquiéAmanda CanoSergi ValeroOscar Sotolongo-GrauAlba Pérez-CordónAna EspinosaÁngela SanabriaGemma OrtegaMaitée Rosende-RocaMontserrat AlegretLluís TárragaMaría Eugenia SáezInés QuintelaÁngel CarracedoLuis M. RealJuan MacíasAnaïs Corma-GómezJuan A. PinedaSilvia MendozaJose Luis RoyoGuillermo Garcia-RibasSebastián García-MadronaEmilio Franco-MacíasDolores Buiza-RuedaMaría Bernal Sánchez-ArjonaRaquel Huerto VilasAlfonso Arias PastorMónica Diez-FairenIgnacio AlvarezCarmen LageDaniel AlcoleaJuan ForteaAlberto LleóAna Frank-GarcíaAngel Martín MontesAnna AntonellManuel Menéndez-GonzálezAdolfo Lopez de MunainMiguel MedinaMiguel CaleroAlberto RábanoAna Belén PastorTeodoro del SerFlorentino Sanchez-GarciaCarmen Muñoz-FernandezM. Candida Deniz-NaranjoDanielle PosthumaOle A. AndreassenDouglas P. WightmanEmil UffelmannHreinn StefanssonG. Bragi WaltersKari StefanssonJon SnaedalHelga EyjólfsdóttirNancy L. PedersenChandra A. ReynoldsIda K. KarlssonSara HäggAnna ZettergrenIngmar SkoogSilke KernMargda WaernKaj BlennowHenrik ZetterbergElisa MorenoMarta Riise MoksnesKristian HveemBendik S. WinsvoldBen BrumptonGeir SelbækTormod FladbyDag AarslandSrdjan DjurovicArvid RongveShahram BahramiAlexey A. ShadrinIngvild SaltvedtGeir Bråthen doi:10.1038/s41588-026-02583-1 Nature Genetics, Published online: 2026-06-03; | doi:10.1038/s41588-026-02583-1 2026-06-03 Nature Genetics 10.1038/s41588-026-02583-1 https://www.nature.com/articles/s41588-026-02583-1 https://www.nature.com/articles/s41588-026-02617-8 Nature Genetics, Published online: 02 June 2026; doi:10.1038/s41588-026-02617-8

This study uses massively parallel reporting assays and CRISPR assays to interrogate chromatin accessibility for genetic variants associated with metabolic liver disease, implicating likely causal variants and genes.]]> Biying ZhuNa HeYang XiaoBin ChenChen LiRavi MandlaYifan LiuJiayu ZhangXiao ChangFulong YuMarijana VujkovicJulie A. LynchKyong-Mi ChangBogdan PasaniucDaniel J. RaderMitchell A. LazarWenxiang Hu doi:10.1038/s41588-026-02617-8 Nature Genetics, Published online: 2026-06-02; | doi:10.1038/s41588-026-02617-8 2026-06-02 Nature Genetics 10.1038/s41588-026-02617-8 https://www.nature.com/articles/s41588-026-02617-8 https://www.nature.com/articles/s41588-026-02601-2 Nature Genetics, Published online: 02 June 2026; doi:10.1038/s41588-026-02601-2

PGS-TRI, a framework designed for analyzing polygenic scores in case–parent trio studies, allows estimation of the risk of an index condition associated with direct and indirect polygenic effects and related gene–environment interactions.]]> Ziqiao WangLuke GrosvenorDebashree RayTianyuan ChengIngo RuczinskiTerri H. BeatyHeather VolkChristine Ladd-AcostaNilanjan Chatterjee doi:10.1038/s41588-026-02601-2 Nature Genetics, Published online: 2026-06-02; | doi:10.1038/s41588-026-02601-2 2026-06-02 Nature Genetics 10.1038/s41588-026-02601-2 https://www.nature.com/articles/s41588-026-02601-2 https://www.nature.com/articles/s41588-026-02631-w Nature Genetics, Published online: 01 June 2026; doi:10.1038/s41588-026-02631-w

As tissues age, mutant clones carrying driver mutations expand, yet the abundance of these variants in normal tissues suggests that fitness-based selection is often uncoupled from malignancy. Cheek et al. introduce a framework that disentangles clonal success from true carcinogenic potential, showing that fitness and fate are not synonymous.]]> Andrew DhawanAndriy MarusykJacob G. Scott doi:10.1038/s41588-026-02631-w Nature Genetics, Published online: 2026-06-01; | doi:10.1038/s41588-026-02631-w 2026-06-01 Nature Genetics 10.1038/s41588-026-02631-w https://www.nature.com/articles/s41588-026-02631-w https://www.nature.com/articles/s41588-026-02643-6 Nature Genetics, Published online: 01 June 2026; doi:10.1038/s41588-026-02643-6

Publisher Correction: Multi-ancestry genome-wide association analyses of refractive error augment genetic discovery and polygenic prediction]]> Fei-Fei ChengXiaoxi LiuHao MiLizhong WangRuilei MaYazhou GuoJulia SidorenkoChen JiangTania IslamAkira MeguroKeiko HikinoYuki IshikawaSenwei TangTeng LiRuoyan ChenLikun WangReedik MägiAndres MetspaluLili MilaniTõnu EskoMari NelisGeorgi HudjashovAdam AutonAlan KwongAnjali J. ShastriBarry HicksCatherine H. WeldonDavid A. HindsEmily DelloRussoEmily M. RiosJoyce Y. TungKahsaia de BritoKatelyn Kukar BondKeng-Han LinMatthew H. McIntyreMatthew J. KmiecikQiaojuan Jane SuRobert K. BellSayantan DasShubham SainiStella AslibekyanVinh TranWanwan XuAlisa P. LehmanNoura S. Abul-HusnR. Ryanne WuRebecca M. K. BernsRuth I. TennenStacey B. DetweilerAditya AmbatiAnna GuanBertram L. KoelschChris GermanÉadaoin HarneyEthan M. JewettG. David PoznikJames R. AshenhurstJingran WenPeter R. WiltonSteven J. MichelettiWilliam A. FreymanMasaki TakeuchiNobuhisa MizukiHélène ChoquetZi-Bing JinGang ChenKun ZhouChikashi TeraoJian ZengJian Yang doi:10.1038/s41588-026-02643-6 Nature Genetics, Published online: 2026-06-01; | doi:10.1038/s41588-026-02643-6 2026-06-01 Nature Genetics 10.1038/s41588-026-02643-6 https://www.nature.com/articles/s41588-026-02643-6 https://www.nature.com/articles/s41588-026-02625-8 Nature Genetics, Published online: 28 May 2026; doi:10.1038/s41588-026-02625-8

Peer Bork (1963–2026)]]> Francesca D. CiccarelliJan O. KorbelChristian Von Mering doi:10.1038/s41588-026-02625-8 Nature Genetics, Published online: 2026-05-28; | doi:10.1038/s41588-026-02625-8 2026-05-28 Nature Genetics 10.1038/s41588-026-02625-8 https://www.nature.com/articles/s41588-026-02625-8