Nature Reviews Neuroscience is the leading review journal in the neurosciences. It publishes articles that review recent progress in brain and nervous system research. Topics range from molecular and cellular aspects of neuronal development and function to behavior, cognition and disorders of the nervous system. By commissioning the best authors to write on the timeliest issues, and following a rigorous peer-review process, the journal provides an unparalleled source of information and opinion for neuroscientists in academia, clinical research and industry. One of the unique features of Nature Reviews Neuroscience is its extraordinary breadth and depth of coverage. This very broad scope – from molecules to mind – captures the essence of modern neuroscience, and allows the journal to attract readers from all areas of this ever-expanding discipline. http://feeds.nature.com/nrn/rss/current Nature Publishing Group en © 2026 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. Nature Reviews Neuroscience © 2026 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. permissions@nature.com https://www.nature.com/uploads/product/nrn/rss.gif http://feeds.nature.com/nrn/rss/current https://www.nature.com/articles/s41583-026-01093-7 Nature Reviews Neuroscience, Published online: 10 November 2026; doi:10.1038/s41583-026-01093-7

The cortico-basal ganglia–thalamic (CBGT) system supports a wide range of behaviours through its modular network organization. Dong and colleagues describe how advanced mesoscale and single-neuron connectomics has refined our understanding of CBGT circuit architecture, providing insights into the network’s capacity to preserve functional specialization while integrating across sensory, motor and cognitive domains.]]> Hong-Wei DongNicholas N. FosterHouri Hintiryan doi:10.1038/s41583-026-01093-7 Nature Reviews Neuroscience, Published online: 2026-11-10; | doi:10.1038/s41583-026-01093-7 2026-11-10 Nature Reviews Neuroscience 10.1038/s41583-026-01093-7 https://www.nature.com/articles/s41583-026-01093-7 https://www.nature.com/articles/s41583-026-01094-6 Nature Reviews Neuroscience, Published online: 10 November 2026; doi:10.1038/s41583-026-01094-6

Extracting insight from nanoscale connectomes presents formidable challenges. In this Review, Betzel and colleagues focus on network science applications to these high-dimensional datasets, providing a high-level overview of different community detection methods while discussing which methods suit which questions and the types of biologically meaningful information they can reveal.]]> Qingyang WangGabrielle J. GutierrezAlexander B. KuninJoshua T. VogelsteinKevin E. BasslerKrešimir JosićRichard Betzel doi:10.1038/s41583-026-01094-6 Nature Reviews Neuroscience, Published online: 2026-11-10; | doi:10.1038/s41583-026-01094-6 2026-11-10 Nature Reviews Neuroscience 10.1038/s41583-026-01094-6 https://www.nature.com/articles/s41583-026-01094-6 https://www.nature.com/articles/s41583-026-01096-4 Nature Reviews Neuroscience, Published online: 06 November 2026; doi:10.1038/s41583-026-01096-4

Single-cell and single-nucleus RNA sequencing technologies have advanced our understanding of the molecular responses of specific cellular populations to Alzheimer disease (AD). Swarup and colleagues outline the insights that these approaches have provided into the multicellular interactions that underlie AD pathogenesis and heterogeneity.]]> Nora EmersonKristen VallejoNegin RahimzadehNellie E. KwangVivek Swarup doi:10.1038/s41583-026-01096-4 Nature Reviews Neuroscience, Published online: 2026-11-06; | doi:10.1038/s41583-026-01096-4 2026-11-06 Nature Reviews Neuroscience 10.1038/s41583-026-01096-4 https://www.nature.com/articles/s41583-026-01096-4 https://www.nature.com/articles/s41583-026-01101-w Nature Reviews Neuroscience, Published online: 02 November 2026; doi:10.1038/s41583-026-01101-w

A population of acetylcholine-sensitive GABAergic neurons in the mouse hippocampus regulates sharp wave ripples and memory consolidation during sleep.]]> Katherine Whalley doi:10.1038/s41583-026-01101-w Nature Reviews Neuroscience, Published online: 2026-11-02; | doi:10.1038/s41583-026-01101-w 2026-11-02 Nature Reviews Neuroscience 10.1038/s41583-026-01101-w https://www.nature.com/articles/s41583-026-01101-w https://www.nature.com/articles/s41583-026-01098-2 Nature Reviews Neuroscience, Published online: 02 November 2026; doi:10.1038/s41583-026-01098-2

Intercellular nanotubes (NTs) provide a structurally distinct route of intercellular communication by enabling cellular material to be selectively transferred between cells. In this Review, Chang, Ryu and Kwon discuss the evidence for NT networks in the nervous system and the experimental approaches that can be used to study NTs in this context.]]> Minhyeok ChangSeungjun RyuHyung-Bae Kwon doi:10.1038/s41583-026-01098-2 Nature Reviews Neuroscience, Published online: 2026-11-02; | doi:10.1038/s41583-026-01098-2 2026-11-02 Nature Reviews Neuroscience 10.1038/s41583-026-01098-2 https://www.nature.com/articles/s41583-026-01098-2 https://www.nature.com/articles/s41583-026-01088-4 Nature Reviews Neuroscience, Published online: 23 October 2026; doi:10.1038/s41583-026-01088-4

Neuronal activity is traditionally viewed as instructing cortical interneuron development. In this Review, Moissidis and Marín discuss how interneurons also actively shape early postnatal network activity, establishing a reciprocal dialogue that drives the maturation of both interneurons and cortical circuits.]]> Monika MoissidisOscar Marín doi:10.1038/s41583-026-01088-4 Nature Reviews Neuroscience, Published online: 2026-10-23; | doi:10.1038/s41583-026-01088-4 2026-10-23 Nature Reviews Neuroscience 10.1038/s41583-026-01088-4 https://www.nature.com/articles/s41583-026-01088-4 https://www.nature.com/articles/s41583-026-01085-7 Nature Reviews Neuroscience, Published online: 16 October 2026; doi:10.1038/s41583-026-01085-7

Age-related changes in endocannabinoid system (ECS) activity might contribute to the decline in cognitive function observed during ageing. In this review, Andreas Zimmer discusses how evidence from genetic and pharmacological studies in mice and humans indicate that relevant cognitive functions may change as a result of changing ECS activity.]]> Andreas Zimmer doi:10.1038/s41583-026-01085-7 Nature Reviews Neuroscience, Published online: 2026-10-16; | doi:10.1038/s41583-026-01085-7 2026-10-16 Nature Reviews Neuroscience 10.1038/s41583-026-01085-7 https://www.nature.com/articles/s41583-026-01085-7 https://www.nature.com/articles/s41583-026-01095-5 Nature Reviews Neuroscience, Published online: 15 October 2026; doi:10.1038/s41583-026-01095-5

A distinct neuropeptide Y2 receptor-expressing neuronal subtype is identified in the brainstem nucleus ambiguus that selectively projects to cardiac ganglia and regulates heart rate and the mammalian diving reflex.]]> Sian Lewis doi:10.1038/s41583-026-01095-5 Nature Reviews Neuroscience, Published online: 2026-10-15; | doi:10.1038/s41583-026-01095-5 2026-10-15 Nature Reviews Neuroscience 10.1038/s41583-026-01095-5 https://www.nature.com/articles/s41583-026-01095-5