Gene Therapy Fulfilling Its Promise

Thu, 29 Jan 2009 12:00:00 EST

NHGRI Senior Investigator Fabio Candotti, M.D., of the Genetics and Molecular Biology Branch, and co-author Donald B. Kohn, M.D., Keck School of Medicine, University of Southern California, comment on prospects for continuing advancement of gene therapy for treatment of genetic diseases in light of the outcome of gene therapy for severe combined immunodeficiency disease, or SCID, due to deficiency of the enzyme adenosine deaminase (ADA), reported in recent trials.

Dr. Canotti's and Dr. Kohn's comments were based on the NEJM article: Gene Therapy for Immunodeficiency Due to Adenosine Deaminase Deficiency [Abstract]

Growth and Patterning in the Limb: Signaling Gradients Make the Decision

Tue, 13 Jan 2009 12:00:00 EST

Alterations in the duration and range of the signaling gradients may underlie many of the morphological differences in the evolution of vertebrate limbs.

NHGRI Recently Published Articles

Gene Therapy Fulfilling Its Promise

Growth and Patterning in the Limb: Signaling Gradients Make the Decision