Nubs of Usmle

Protooncogenes

2008-08-02T07:31:00.003+05:30

ForSynthesis of GF - sisSynthesis of GF receptors - erbB2/neu(HER-2) & retSignal Transduction (Membrane related GTP binding proteins) - rasSignal Transduction (non-receptor tyrosine kinase) - ablSynthesize nuclear transcription regulators - myc and N-myc

Methemoglobinemia

2008-07-10T15:41:00.002+05:30

Heme in Ferric state instead of Ferrous.O2 content: DecreasedPaO2: NormalSaO2: Decreased (Ferric state cannot bind O2)Left shifts O2 Dissociation curveCauses:---> Heme oxidized by nitro/sulfa drugs: Dapsone, Primaquine, Nitroglycerin, Quinine, Trimethoprim/Sulfamethoxazole, Nitrofurantoin.---> Person coming from Rocky Mountains - Have high Nitro compounds in such area---> Common in HIV - Bcoz

CO Poisoning

2008-07-10T15:32:00.005+05:30

O2 content: DecreasedPaO2: NormalSaO2: Decreased(Higher affinity of CO for Hb than O2)Left shifts O2 dissociation curveInhibits Cytochrome oxidaseCauses:Car exhaustSpace heatersSmoke inhalation in fires(house fires-also have cyanide poisoning)Wood stovesMethylene ChlorideS/S:HeadacheCherry red color of CO-Hb, masks cyanosis.Long term: Necrosis of Globus Pallidus leading to Parkinson-like

Normal Flora

2008-07-04T15:30:00.003+05:30

Blood and Internal OrgansFlora: None; Generally SterileCutaneous surfaces + urethra + outer earFlora: Staph. epidermidis(MC)Staph. aureusCorynebacteriaStreptococciAnaerobes, e.g. Pepto-streptococciYeasts(Candida species)NoseFlora:Staph. aureus(MC)Staph. epidermidisOropharynxFlora:Strep. viridans including Strep mutans(MC)Nonpathogenic NeisseriaNontypeable H. Influenza(i.e. one with no capsule)

California Letter

2008-07-03T16:00:00.004+05:30

..... Hey guys.. Came across this blog from Harshit, where he has given near complete info on how to obtain a California Letter, also known as PTAL(Post-graduation Training Authorization Letter).. Check the link below..California LetterDon't tell me the procedure is too hectic guys..U expect California Residency for nothing, Do ya??

MTP Act

2008-06-30T11:36:00.003+05:30

MTP Act: It is an Act to provide for the termination of certain pregnancies by registered Medical Practitioners.:Short title, extent and commencement:1) This Act may be called the Medical Termination of Pregnancy Act, 1971.2) It extends to the whole of India except the State of Jammu and Kashmir.:Definitions: -

Myasthenia Gravis

2008-06-30T10:27:00.010+05:30

..... Myasthenia Gravis is a neuro-muscular disorder charecterized by weakness and fatigability of skeletal muscles.Defect: Decrease in the number of available Acetyl-Choline receptors(AChRs) at the neuro-muscular(NM) junctions due to an antibody-mediated autoimmune attack.Normal Phyz at NM Junction:.... At NM Junction Acetyl Choline(ACh) is synthesized in motor nerve terminals and stored in

Coagulation pathway

2008-06-18T13:41:00.004+05:30

Factor I -----> FibrinogenFactor II -----> ProthrombinFactor III -----> Tissue factor; Tissue thromboplastinFactor IV -----> CalciumFactor V -----> Pro-accelerin; Labile factor; Ac-GFactor VII -----> Pro-convertin; Stable factorFactor VIII -----> Anti-hemophilic AFactor IX

Antiviral Drugs

2008-03-09T20:54:00.004+05:30

Many Anti-viral drugs are anti-metabolites..1) Those who block viral penetration/ uncoating - Amantadine, Enfurvitide2) Those who inhibit DNA polymerase - They end in "-clovir"3) Those who inhibit RNA polymerase - Ribavirin4) Those who inhibit both DNA and RNA polymerase - Foscarnet5) Those who inhibit Reverse transcriptase - They end in "-ine" [Exception: Efavirenz which is reverse transcriptase

Green Card during Residency...!!!!!!!!!!

2007-11-22T21:25:00.000+05:30

Roaming about on the blogs of Usmle to Md, i found this interesting post..Take a thought, wat if someone gives you greencard during first year IM residency itself..!!Read more on this link..Crozer Chester IM residency program to sponsor Greencards

cool link

2007-11-08T21:21:00.000+05:30

hey guys...found this link in first aid...just have to register there and u'll get the access to a full 350 que exam...for free...http://www.lww.com/medstudent/usmle/enjoy..

Radiology Sites for Usmle

2007-11-01T01:08:00.002+05:30

...Hey guys......There has always been confusion as in - From where can we get hold on some X-rays, CT's or MRI for Usmle Step 1 ?? Confusion prevails... The Sectional Anatomy site was considered best.. Sadly, those moderators just screwed it up to make it a pay site.. What less - that pay site is not for anyone and everyone, it is now available only to some institution which specifically

MRI/CT - Contraindications vs Indications

2007-10-29T21:18:00.000+05:30

Whenever a question stem on the step 2 or Step 3 says that the patient has any metallic object implants like pacemakers , prosthetic metal valves, etc - MRI is contraindicated in such a patient.. CT's are preferred in these situation and even or else, cause they are cheaper and can detect pathologies with almost equal effectiveness..MRIs are generally preferred in spine conditions and early