Online Medicine Resource

MALE INFERTILITY TREATMENT OPTIONS

noreply@blogger.com (Manzoor Majeed) — Fri, 16 Apr 2010 06:56:00 +0000

The introduction of Intracytoplasmic Sperm Injection (ICSI) over the past five years has revolutionised the management of male infertility.

Intracytoplasmic sperm injection (ICSI) is an in vitro fertilization procedure in which a single sperm is injected directly into an egg; this procedure is most commonly used to overcome male infertility problems.

The procedure is done under a microscope using micromanipulation devices (micromanipulators, microinjectors and micropipettes). A holding pipette (on picture on left) stablizes the mature oocyte. from the opposite site a thin, hollow needle is pierced into the inner part of the oocyte, the oolemma. it is loaded with a single sperm that will be released into the oocyte. The pictured oocyte has an extruded polar body at about 12 o'clock indicating its maturity. After the procedure, the oocyte will be placed into cell culture and checked on the following day for signs of fertilization.

In natural fertilisation sperm compete and when the first sperm enters the egg cell, the egg cell blocks the entry of any other sperm. Concern has been raised that in ICSI this sperm selection process is bypassed and the sperm is selected by the embryologist without undergoing any specific testing. However, in mid 2006 the FDA cleared a device that allows embryologists to select mature sperm for ICSI based on sperm binding to hyaluronan, the main constituent of the gel layer (cumulus oophorus) surrounding the oocyte. The device provides microscopic droplets of hyaluronan hydrogel attached to the culture dish. The embryologist places the prepared sperm on the microdot, selects and captures sperm that bind to the dot. Basic research on the maturation of sperm shows that hyaluronan-binding sperm are more mature and show fewer DNA strand breaks and significantly lower levels of aneuploidy than the sperm population from which they were selected.

There is some suggestion that birth defects are increased with the use of IVF in general, and ICSI specifically. It is hoped that use of new device (PICSI) will lower the apparently elevated level of birth defects associated with ICSI.

Medical conditions - Causes of Male Infertility

noreply@blogger.com (Manzoor Majeed) — Fri, 16 Apr 2010 06:51:00 +0000

There are various medical conditions that can cause infertility which include:

Diabetes
Pituitary gland disease
Hypothalamus disorder
Multiple sclerosis
Chlamydia
Prostatitis
Cushing’s syndrome
Hypogonadism
Mumps

There are two types of diabetes – Type 1 and Type 2 which are both to do with abnormally high levels in sugar in the bloodstream. Type 1 starts in childhood and is where the body is unable to produce any insulin.

Type 2 affects mainly older people and is where the body is unable to produce enough insulin. It is also known as ‘insulin-dependant’ diabetes.

How does this relate to infertility? A body of research has shown that there is a link between diabetes and male infertility. It appears to be the case that sperm produced by a man with diabetes are more damaged than those from a non-diabetic.

These damaged sperm are unable to fertilise an egg which leads to problems with conceiving.

Further studies are needed in order to determine the extent of the problem but it does seem to suggest that this will be a major cause of male infertility in the future.

Pituitary gland disease is classed as a hormonal problem and one of the many causes of male infertility. If it fails to send the correct signals to activate the testes then testosterone levels will drop which affects sperm production.

The hypothalamus is responsible for testosterone production but problems with this can reduce testosterone levels which directly impacts upon fertility levels.

Multiple sclerosis is a condition which affects myelin – the protective coating on nerve fibres which enable messages to be transmitted from the brain to the rest of the body. This myelin becomes damaged which then affects these messages.

In respect of male fertility, the layer of myelin on the nerves which control sexual response become damaged which disrupts this response, leading to problems with erection and ejaculation.

Chlamydia is a sexually transmitted disease (STD) which has come to our attention in recent years. It is most prevalent in young people and is a major area of concern for experts as it can have long term effects. And one of these effects is infertility.

It affects the quantity, shape and movement of sperm which damages male fertility.

Prostatitis is inflammation of the prostate gland which can cause permanent infertility if left untreated. Symptoms of this include painful ejaculation and urination.

Cushing’s syndrome is a hormonal disorder which is caused by excessive levels of cortisol in the body. Cortisol is produced by the adrenal glands and is responsible for a variety of functions which include: regulating blood pressure and the immune system, controlling blood sugar levels and an appropriate response to stress (‘fight or flight’).

But too much cortisol causes a whole range of problems which include:

Muscle weakness
Obesity
Water retention (around the ankles)
Reduced libido (and reduced fertility)
High blood pressure
Aches and pains
Excess thirst
Mood swings

Reduced libido (or lack of a sex drive) is likely to affect your sexual performance and ability to conceive.

Hypogonadism is a condition which can occur as a result of an injury or disease to the pituitary glands, hypothalamus or testicles. It can decrease the levels of the hormone gonadotrophin which in turn, lowers testosterone levels.

Lowered testosterone levels inhibit sperm production and may cause erectile dysfunction.

Mumps is a common childhood illness which usually causes no long term effects but, complications do happen. It is especially problematic for adult men as it can infect the testicles, causing orchitis which may cause sterility.

Around 20 to 30% cases of men with mumps experience orchitis. Symptoms of this include tenderness, swelling and a fever and it tends to occur a week after the outbreak of the disease.

Other general medical conditions which cause infertility include kidney disease, cancer, high blood pressure, stroke and coronary heart disease.

Failure to ejaculate - Causes of Male Infertility

noreply@blogger.com (Manzoor Majeed) — Fri, 16 Apr 2010 06:51:00 +0000

Ejaculation problems include a failure to ejaculate, sperm retention or a flushing of sperm into the bladder instead (known as retrograde ejaculation).

Problems with ejaculation can be caused by the following:

Disease such as multiple sclerosis or diabetes
Paralysis (spinal cord injury)
Damage occurred during surgery
Psychological issues
Certain medications such as high blood pressure medication

Other ejaculation problems include premature ejaculation and delayed ejaculation. Premature ejaculation is the condition in which the man ejaculates too quickly during sexual intercourse. This is much more common than delayed ejaculation in which ejaculation doesn’t happen straight away even though you have a normal erection.

Prescription medicines - Causes of Male Infertility

noreply@blogger.com (Manzoor Majeed) — Fri, 16 Apr 2010 06:48:00 +0000

A prescription medicine is designed to treat a particular complaint but many of them have side effects which can affect fertility. The use and indeed the overuse of these have been found to cause infertility.

What doesn’t help matters is when the medicine prescribed for a condition then causes another set of symptoms which impact upon fertility levels.

Problems to be aware of include:

Erectile dysfunction
Low sperm count
Hormone imbalance

If you are trying to conceive but require prescription medicines then discuss your concerns with your GP. He or she can recommend an alternative and the best way of changing from your current medication to a less risky one.

This also applies to over the counter medicines. These may seem fairly innocuous but they can have side effects, and one of these may be infertility. We tend to buy these assuming that they will cure whatever condition we have but they may not be the best option.

If you are thinking of doing this then check with your GP first before purchasing over the counter medicines from your local chemist or pharmacy.

At the end of the day you want to ensure that your reproductive system is in the best shape it can be when planning a family. So ensure that your lifestyle poses no or minimal risk to your fertility.

Another issue is that of cancer treatment: if you have been receiving radiation therapy or chemotherapy then this does affect fertility. In some cases it causes short term infertility but in others it can lead to long term infertility problems.

Cancer drugs can affect the quality and quantity of sperm produced as well as problems with ejaculation.

Speak to your GP or fertility specialist about this if you have to undergo chemotherapy or radiation therapy. He or she may advise you to store your sperm in a sperm bank prior to your cancer treatment which will help to preserve them.

Environmental issues (exposure to toxins etc) - Causes of Male Infertility

noreply@blogger.com (Manzoor Majeed) — Fri, 16 Apr 2010 06:47:00 +0000

These refer to potential hazards at work, in the home and during leisure.

If you work with hazardous chemicals such as pesticides, solvents and fuels then consider that these have been linked to fertility issues so discuss this further with your employer. If you are bothered by this then see if your employer will allow you to change jobs or move to another department whilst undergoing fertility tests.

If this is not possible then ensure that you follow guidelines prescribed by your health and safety department, wear protective clothing if necessary and shower afterwards to remove any potentially damaging chemicals.

Other factors which can affect your fertility include a lack of activity and overheated environments. If you are inactive at work and tend to sit down for long periods of time then what happens is that your core temperature rises which overheats the testes and so reduces sperm count.

If you have a job which requires you to sit down for long periods of time then try to take short breaks. And wear loose fitting underwear such as boxer shorts which allows the testes to remain cool and the sperm healthy.

Another work related aspect is if your job requires you to do any heavy lifting or carrying. There is a risk of injuring your back or an abdominal strain (hernia) which may affect your fertility. If you do have to lift anything then take extra care whilst doing so or see if you can change duties in the meantime.

This equally applies to any manual work you may do around the home.

As regards leisure: certain sports especially contact sports such as rugby have a high risk of injury, for example to the groin area. Other equally risky sports include heavy weightlifting and endurance cycling. It may be a good idea to ease off on these or change to something less rigorous whilst trying to conceive.

Lifestyle issues - Causes of Male Infertility

noreply@blogger.com (Manzoor Majeed) — Fri, 16 Apr 2010 06:46:00 +0000

These include diet, smoking, alcohol consumption and even the type of pants you wear!

Smoking lowers sperm count as well as affecting sperm quality so both the quality and quality of your sperm are affected. In fact, this sperm count can be 13 to 17% lower in men who smoke as compared to non-smoking males.

It can also damage the blood vessels within the penis which decreases blood flow and causes ineffective erections.

These are all good reasons to give up smoking if you and your partner are trying to conceive.

Visit our female infertility section to learn more about the effects of smoking on your partner.

Another aspect is alcohol: alcohol consumption can affect fertility in both men and women. Even a moderate amount of alcohol can have quite a drastic effect. With men it can reduce the size of the testicles, lower sperm count, decrease the quality of the sperm (more poor quality sperm), decrease libido and even cause impotence.

You may enjoy a few drinks after work or at the weekend when socialising but you need to look at your intake if you are trying to conceive. It is better to limit this to the occasional drink rather than on a regular basis.

This equally applies to your partner as drinking can also affect the woman’s fertility.

Your diet plays more of a part in fertility than you think. A healthy diet, rich in antioxidants, especially vitamins C and E are particularly crucial for fertility. They can boost sperm production, ensuring that these sperm are of a superior quality and likely to fertilise an egg.

Conversely, a diet which is lacking in certain vitamins and minerals, for example, zinc, can reduce the volume of semen produced by the male. A certain amount of semen is required for fertilisation and a diet which is deficient in zinc will affect this.

If you feel that you are lacking in zinc then introduce the following zinc rich foods into your diet:

Wheat germ
Seafood
Beef
Lamb

Other factors which can affect sperm count include: wearing tight underwear, riding a bicycle for a long period of time (the saddle puts pressure on the groin which can damage arteries and nerves) and drug use (cannabis, cocaine or steroids)

Vasectomy - Causes of Male Infertility

noreply@blogger.com (Manzoor Majeed) — Fri, 16 Apr 2010 06:44:00 +0000

A vasectomy is a surgical procedure in which the vas deferens (the tube which carries sperm) is cut and tied off to prevent sperm from accessing the ejaculatory semen.

This won’t affect your sex drive or the ability to ejaculate but your semen won’t contain any sperm. You will still produce sperm but these cannot escape via your penis and are naturally absorbed by your body.

As a result of this many men consider this to be a permanent state of affairs and usually choose to have this operation if they are not planning on starting a family. It is also known as male sterilisation.

The procedure can be reversed via a vasectomy reversal operation but this is not a guarantee of future fertility.

If you have undergone this procedure and want it reversed check with your GP as success rates depend on the length of time between the original procedure and the reversal.

Blockage in the ejaculatory duct - Causes of Male Infertility

noreply@blogger.com (Manzoor Majeed) — Fri, 16 Apr 2010 06:42:00 +0000

The ejaculatory duct is the part of the male reproductive system which enables sperm to travel from the epididymis to the ejaculatory fluid.

The ejaculatory duct consists of the epididymi and the vas deferens. The epididymi are two coiled tubes which store and transport sperm from the testes. This sperm then moves from the epididymi to the vas deferens, ready for ejaculation.

This is a straightforward process but in a small percentage of cases this duct becomes blocked which prevents the sperm from reaching your partner’s egg in order to fertilise it.

A blockage can be caused by a groin injury, congenital defect, vasectomy or a sexually transmitted disease (STD).

Surgery is required to remove the blockage and this generally has a high success rate.

Disease or trauma to the testicles - Causes of Male Infertility

noreply@blogger.com (Manzoor Majeed) — Fri, 16 Apr 2010 06:41:00 +0000

An injury or disease to the testicles can reduce their function and so impact upon fertility. For example, a blow received playing sport or as a result of a fight.

This can affect the blood supply to the testicles which damages the ability produce sperm.

Viral infections such as orchitis (painful swelling of the testicles) can also mean a failure to produce sperm.

Surgery can be carried out to treat any of these but it is not a guarantee of fertility.

Variococele - Causes of Male Infertility

noreply@blogger.com (Manzoor Majeed) — Fri, 16 Apr 2010 06:40:00 +0000

This is a medical condition which affects the blood vessels of the penis. These veins are designed to channel blood away from the penis and scrotum but if they become diseased then the ability to do so is affected.

These diseased veins look very similar to the varicose veins seen on the legs.

What happens is that these veins become enlarged and swollen which causes the blood to pool within them. This can then cause the temperature of the scrotum to rise which reduces the number of sperm in the testis.

If you develop variococele then it doesn’t automatically mean that you will become infertile but it does increase that risk.

Genetic disorders - Causes of Male Infertility

noreply@blogger.com (Manzoor Majeed) — Fri, 16 Apr 2010 06:36:00 +0000

These are uncommon but do occur in men who have low or no sperms. Some of these are not immediately obvious but there is concern over one particular type of gene which causes problems with the Y-chromosome. This can be passed down to male offspring as a result of an assisted fertility technique such as intracytoplasmic sperm injection (ICSI). And this can lead to infertility.

Another genetic disorder is Klinefelters syndrome which leads to an extra Y-chromosome in men. It is also known as ‘trisomy’ and is characterised as XYY rather than the usual male XY configuration.

It is easy to assume that men who have this extra chromosome will be extra fertile but unfortunately the opposite is true. They tend to have serious fertility problems and are often classed as being sterile.

Abnormal/low sperm count - Causes of Male Infertility

noreply@blogger.com (Manzoor Majeed) — Fri, 16 Apr 2010 06:34:00 +0000

Around 75% of cases of male infertility are due to a low or abnormal sperm count.

The medical term for low sperm count is oligospermia and this is now defined as 10 million/ml of semen although this figure used to be set at 40 million/ml. The reason for this is that if your female partner is young and healthy then a sperm count as low as 10 million/ml can still achieve conception.

Bear in mind that sperm counts do vary over time so a temporary low count is not uncommon. So, if you undergo a fertility test which reports a low sperm count then this may not be an accurate reading.

An abnormal sperm is one that it is abnormally shaped which makes it more difficult for that sperm to travel through the fallopian tube and fertilise an egg.

There are certain drugs such as anabolic steroids, sulfasalazine and chemotherapy medication which can cause a low sperm count.

Another factor is that of trauma or injury to the testicles. If you have sustained an injury to your testicles or have undergone surgery for testicular cancer then your sperm count will be affected.

Other aspects to take into account are sperm movement and shape. The shape and movement of a sperm can determine how likely it is to fertilise an egg. As you can guess a sperm which is oddly shaped or moves very slowly is unlikely to fertilise an egg.

The medical term for low quality sperm is dysspermia.

Ideally you need 60% normal sperm to guarantee fertility so quality can be more important than quantity.

MALE INFERTILITY

noreply@blogger.com (Manzoor Majeed) — Fri, 16 Apr 2010 06:33:00 +0000

Male infertility accounts for around 20 to 25% of infertility cases which is higher than many people think. It is easy to assume that infertility is a female problem, which is the traditional view, but it’s often the case that the man has the problem rather than the woman.

There are many reasons for male infertility which include the following:

Hormone disorders
Abnormal/low sperm count
Genetic disorders
Variococele
Disease or trauma to the testicles
Blockage in the ejaculatory duct
Vasectomy
Lifestyle issues
Environmental issues (exposure to toxins etc)
Prescription medicines
Failure to ejaculate
Medical conditions

There are a small percentage of cases in which there appears to be no obvious cause of infertility. These are known as ‘idiopathic’ cases.

Male infertility problems are often categorised into four areas: hormonal, structural, lifestyle and genetic. And many of these are related to each other. In other words, a genetic cause of infertility can also be related to a structural problem (e.g. damage to the male reproductive organs).

Hormone disorders

The reproductive endocrine system exists in a delicate state of balance which can easily be upset. The main hormones of this system are testosterone, follicle stimulating hormone (FSH) and luteinizing hormones (LH). These are responsible for male fertility.

Any problem in the central nervous system such as the adrenal glands or thyroid glands can minimise the production of LH and FSH which then impacts upon fertility. For example, a problem with the adrenal glands can cause low testosterone levels which also affect fertility.

LISTERIA

noreply@blogger.com (Manzoor Majeed) — Fri, 16 Apr 2010 06:31:00 +0000

What is listeriosis (Listeria infection)?

Listeriosis, a serious infection caused by eating food contaminated with the bacterium Listeria monocytogenes, is an important public health problem. The disease primarily affects pregnant women, newborns, and adults with weakened immune systems. It can be avoided by following a few simple recommendations.

What are the symptoms of listeriosis?

A person with listeriosis (listeria infection) has fever, muscle aches, and sometimes gastrintestinal symptoms such as nausea or diarrhoea. If infection spreads to the nervous system, symptoms such as headache, stiff neck, confusion, loss of balance, or convulsions can occur.

Infected pregnant women may experience only a mild, flu-like illness; however, infections during pregnancy can lead to miscarraige or stillbirth, premature delivery, or infection of the newborn.

How great is the risk for listeriosis?

In the United States, an estimated 2,500 persons become seriously ill with listeriosis each year. Of these, 500 die. At increased risk are:

Pregnant women - They are about 20 times more likely than other healthy adults to get listeriosis. About one-third of listeriosis cases happen during pregnancy.
Newborns - Newborns rather than the pregnant women themselves suffer the serious effects of infection in pregnancy.
Persons with weakened immune systems
Persons with cancer, diabetes, or kidney disease
Persons with AIDS - They are almost 300 times more likely to get listeriosis than people with normal immune systems.
Persons who take glucocorticosteroid medications
The elderly

Healthy adults and children occasionally get infected with Listeria, but they rarely become seriously ill.

How does Listeria get into food?

Listeria monocytogenes is found in soil and water. Vegetables can become contaminated from the soil or from manure used as fertilizer.
Animals can carry the bacterium without appearing ill and can contaminate foods of animal origin such as meats and dairy products. The bacterium has been found in a variety of raw foods, such as uncooked meats and vegetables, as well as in processed foods that become contaminated after processing, such as soft cheeses and cold cuts at the deli counter. Unpasteurized (raw) milk or foods made from unpasteurized milk may contain the bacterium.

Listeria is killed by pasteurization and cooking; however, in certain ready-to-eat foods such as hot dogs and deli meats, contamination may occur after cooking but before packaging.

How do you get listeriosis?

You get listeriosis by eating food contaminated with Listeria. Babies can be born with listeriosis if their mothers eat contaminated food during pregnancy. Although healthy persons may consume contaminated foods without becoming ill, those at increased risk for infection can probably get listeriosis after eating food contaminated with even a few bacteria. Persons at risk can prevent Listeria infection by avoiding certain high-risk foods and by handling food properly.

Can listeriosis be prevented?

The general guidelines recommended for the prevention of listeriosis are similar to those used to help prevent other foodborne illnesses, such as salmonellosis.

How can you reduce your risk for listeriosis?

General recommendations:

Thoroughly cook raw food from animal sources, such as beef, pork, or poultry.
Wash raw vegetables thoroughly before eating.
Keep uncooked meats separate from vegetables and from cooked foods and ready-to-eat foods.
Avoid unpasteurized (raw) milk or foods made from unpasteurized milk.
Wash hands, knives, and cutting boards after handling uncooked foods.
Consume perishable and ready-to-eat foods as soon as possible.

Recommendations for persons at high risk, such as pregnant women and persons with weakened immune systems, in addition to the recommendations listed above:

Do not eat hot dogs, luncheon meats, or deli meats, unless they are reheated until steaming hot.
Avoid getting fluid from hot dog packages on other foods, utensils, and food preparation surfaces, and wash hands after handling hot dogs, luncheon meats, and deli meats.
Do not eat soft cheeses such as feta, Brie, and Camembert, blue-veined cheeses, or Mexican-style cheeses such as queso blanco, queso fresco, and Panela, unless they have labels that clearly state they are made from pastuerized milk.
Do not eat refrigerated p�t�s or meat spreads. Canned or shelf-stable p�t�s and meat spreads may be eaten.
Do not eat refrigerated smoked seafood, unless it is contained in acooked dish, such as a casserole. Refrigerated smoked seafood, such as salmon, trout, whitefish, cod, tuna or mackerel, is most often labeled as "nova-style," "lox," "kippered," "smoked," or "jerky." The fish is found in the refrigerator section or sold at deli counters of grocery stores and delicatessens. Canned or shelf-stable smoked seafood may be eaten.

How do you know if you have listeriosis?

There is no routine screening test for susceptibility to listeriosis during pregnancy, as there is for rubella and some other congenital infections. If you have symptoms such as fever or stiff neck, consult your doctor. A blood or spinal fluid test (to cultivate the bacteria) will show if you have listeriosis. During pregnancy, a blood test is the most reliable way to find out if your symptoms are due to listeriosis.

What should you do if you've eaten a food recalled because of Listeria contamination?

The risk of an individual person developing Listeria infection after consumption of a contaminated product is very small. If you have eaten a contaminated product and do not have any symptoms, we do not recommend that you have any tests or treatment, even if you are in a high-risk group. However, if you are in a high-risk group, have eaten the contaminated product, and within 2 months become ill with fever or signs of serious illness, you should contact your physician and inform him or her about this exposure.

Can listeriosis be treated?

When infection occurs during pregnancy, antibiotics given promptly to the pregnant woman can often prevent infection of the foetus or newborn.

Babies with listeriosis receive the same antibiotics as adults, although a combination of antibiotics is often used until physicians are certain of the diagnosis. Even with prompt treatment, some infections result in death. This is particularly likely in the elderly and in persons with other serious medical problems.

IVF (IN VITRO FERTILISATION) AND GIFT (GAMETE INTRA FALLOPIAN TRANSFER)

noreply@blogger.com (Manzoor Majeed) — Wed, 19 Aug 2009 07:14:00 +0000

What is IVF?

In vitro fertilisation (IVF) is a technique in which egg cells are fertilised by sperm outside the woman's womb. IVF is a major treatment in infertility when other methods of achieving conception have failed.

The process involves hormonally controlling the ovulatory process, removing ova (eggs) from the woman's ovaries and letting sperm fertilise them in a fluid medium. The fertilised egg (zygote) is then transferred to the patient's uterus with the intent to establish a successful pregnancy.

What is GIFT?

Gamete intrafallopian transfer (GIFT) is an infertility treatment in which eggs are removed from a woman's ovaries, and placed in one of the fallopian tubes, along with the man's sperm. This allows fertilization to take place inside the woman's body.

It takes, on average, four to six weeks to complete a cycle of GIFT. First, the woman must take a fertility drug to stimulate egg production in the ovaries. The doctor will monitor the growth of the ovarian follicles, and once they are mature, the woman will be injected with Human chorionic gonadotropin (hCG). The eggs will be harvested approximately 36 hours later, mixed with the man's sperm, and placed back into the woman's Fallopian tubes using a laparoscope.

A woman must have at least one normal fallopian tube in order for GIFT to be suitable. It is used in instances where the fertility problem relates to sperm dysfunction, and where the couple has idiopathic (unknown cause) infertility. Some patients may prefer the procedure to IVF for ethical reasons, since the fertilization takes place inside the body.

As with most fertility procedures, success depends on the couple's age and the woman's egg quality. It is estimated that approximately 25-30% of GIFT cycles result in pregnancy, with a third of those being multiple pregnancies.

Many specialists in infertility would look at GIFT as a procedure that is outdated (2004) as pregnancy rates in IVF tend to be equal or better and do not require laparoscopy.

IVF Method

Ovarian stimulation

Treatment cycles are typically started on the third day of menstruation and consist of a regimen of fertility medications to stimulate the development of multiple follicles of the ovaries. In most patients injectable gonadotropins (usually FSH analogues) are used under close monitoring. Such monitoring frequently checks the oestradiol level and, by means of gynaecologic ultrasonography, follicular growth. Typically approximately 10 days of injections will be necessary. Endogenous ovulation is blocked by the use of GnRH agonists or GnRH antagonists.

Oocyte retrieval

When follicular maturation is judged to be adequate, human chorionic gonadotropin (β-hCG) is given. This agent, which acts as an analogue of luteinising hormone, would cause ovulation about 36 hours after injection, but a retrieval procedure takes place just prior to that, in order to recover the egg cells from the ovary. The eggs are retrieved from the patient using a transvaginal technique involving an ultrasound-guided needle piercing the vaginal wall to reach the ovaries. Through this needle follicles can be aspirated, and the follicular fluid is handed to the IVF laboratory to identify ova. The retrieval procedure takes about 20 minutes and is usually done under conscious sedation or general anaesthesia.

IVF laboratory

In the laboratory, the identified eggs are stripped of surrounding cells and prepared for fertilisation. In the meantime, semen is prepared for fertilisation by removing inactive cells and seminal fluid. The sperm and the egg are incubated together (at a ratio of about 75,000:1) in the culture media for about 18 hours. By that time fertilisation should have taken place and the fertilised egg would show two pronuclei. In situations where the sperm count is low a single sperm is injected directly into the egg using intracytoplasmic sperm injection (ICSI). The fertilised egg is passed to a special growth medium and left for about 48 hours until the egg has reached the 6-8 cell stage.

Laboratories have developed grading methods to judge oocyte and embryo quality. Typically, embryos that have reached the 6-8 cell stage are transferred three days after retrieval.

Embryo transfer

Embryos are graded by the embryologist based on the number of cells, evenness of growth and degree of fragmentation. The number to be transferred depends on the number available, the age of the woman and other health and diagnostic factors. In countries such as the UK, Australia and New Zealand, a maximum of two embryos are transferred except in unusual circumstances. This is to limit the number of multiple pregnancies. The embryos judged to be the "best" are transferred to the patient's uterus through a thin, plastic catheter, which goes through her vagina and cervix. Several embryos may be passed into the uterus to improve chances of implantation and pregnancy.

Post-transfer

The patient has to wait two weeks before she returns to the clinic for the pregnancy test. During this time she may receive progesterone—a hormone that keeps the uterus lining thickened and suitable for implantation. Many IVF programmes provide additional medications as part of their protocol.

Success rates

Chance of a successful pregnancy is approximately 15% for each IVF cycle, although selected clinics are now able to claim rates up to 50% per cycle. There are many factors that determine success rates including the age of the patient, the quality of the eggs and sperm, the duration of the infertility, the health of the uterus, and the medical expertise. It is a common practice for IVF programmes to boost the pregnancy rate by placing multiple embryos during embryo transfer. A flip side of this practice is a higher risk of multiple pregnancy, itself associated with obstetric complications.

IVF programmes generally publish their pregnancy rates. However, comparisons between clinics are difficult as many variables determine outcome. Furthermore, these statistics depend strongly on the type of patients selected.

There are many reasons why pregnancy may not occur following IVF and embryo transfer, including

The timing of ovulation may be misjudged, or ovulation may not be able to be predicted or may not occur
Attempts to obtain eggs that develop during the monitored cycle may be unsuccessful
The eggs obtained may be abnormal or may have been damaged during the retrieval process
A semen specimen may not be able to be provided
Fertilization of eggs to form embryos may not occur
Cleavage or cell division of the fertilised eggs may not take place
The embryo may not develop normally
Implantation may not occur
Equipment failure, infection and/or human error or other unforeseen and uncontrollable factors, which may result in the loss of or damage to the eggs, the semen sample and/or the embryos.

Potential Complications

The major complication of IVF is the risk of multiple births. This is directly related to the practice of transferring multiple embryos at embryo transfer. Multiple births are related to increased risk of pregnancy loss, obstetrical complications, prematurity, and neonatal morbidity with the potential for long term damage. Strict limits on the number of embryos that may be transferred have been enacted in some countries (e.g., England) to reduce the risk of high-order multiples (triplets or more), but are not universally followed or accepted. Spontaneous splitting of embryos in the womb after transfer does occur, but is rare (<1%)>

Another risk of ovarian stimulation is the development of ovarian hyperstimulation syndrome.

INFERTILITY What is infertility?

noreply@blogger.com (Manzoor Majeed) — Wed, 19 Aug 2009 07:06:00 +0000

Most experts define infertility as not being able to get pregnant after at least one year of trying. Women who are able to get pregnant but then have repeat miscarriages are also said to be infertile.

Pregnancy is the result of a complex chain of events. In order to get pregnant:

A woman must release an egg from one of her ovaries (ovulation).
The egg must go through a fallopian tube toward the uterus (womb).
A man's sperm must join with (fertilize) the egg along the way.
The fertilized egg must attach to the inside of the uterus (implantation).

Infertility can result from problems that interfere with any of these steps.

Is infertility a common problem?

About 1 in 10 women have difficulty getting pregnant or carrying a baby to term.

Is infertility just a woman's problem?

No, infertility is not always a woman's problem. In only about one-third of cases is infertility due to the woman (female factors). In another one third of cases, infertility is due to the man (male factors). The remaining cases are caused by a mixture of male and female factors or by unknown factors.

What causes infertility in men?

Infertility in men is most often caused by:

problems making sperm -- producing too few sperm or none at all
problems with the sperm's ability to reach the egg and fertilize it -- abnormal sperm shape or structure prevent it from moving correctly

Sometimes a man is born with the problems that affect his sperm. Other times problems start later in life due to illness or injury. For example, cystic fibrosis often causes infertility in men.

What increases a man's risk of infertility?

The number and quality of a man's sperm can be affected by his overall health and lifestyle. Some things that may reduce sperm number and/or quality include:

alcohol
drugs
environmental toxins, including pesticides and lead
smoking cigarettes
health problems
medicines
radiation treatment and chemotherapy for cancer
age

What causes infertility in women?

Problems with ovulation account for most cases of infertility in women. Without ovulation, there are no eggs to be fertilized. Some signs that a woman is not ovulating normally include irregular or absent menstrual periods.

Less common causes of fertility problems in women include:

blocked fallopian tubes due to pelvic inflammatory disease, endometriosis, or surgery for an ectopic pregnancy
physical problems with the uterus
uterine fibroids

What things increase a woman's risk of infertility?

Many things can affect a woman's ability to have a baby. These include:

age
stress
poor diet
athletic training
being overweight or underweight
tobacco smoking
alcohol
sexually transmitted diseases (STDs)
health problems that cause hormonal changes

How does age affect a woman's ability to have children?

More and more women are waiting until their 30s and 40s to have children. Actually, about 20 percent of women in the United States now have their first child after age 35. So age is an increasingly common cause of fertility problems. About one third of couples in which the woman is over 35 have fertility problems.

Aging decreases a woman's chances of having a baby in the following ways:

The ability of a woman's ovaries to release eggs ready for fertilization declines with age.
The health of a woman's eggs declines with age.
As a woman ages she is more likely to have health problems that can interfere with fertility.
As a women ages, her risk of having a miscarriage increases.

How long should women try to get pregnant before calling their doctors?

Most healthy women under the age of 30 shouldn't worry about infertility unless they've been trying to get pregnant for at least a year. At this point, women should talk to their doctors about a fertility evaluation. Men should also talk to their doctors if this much time has passed.

In some cases, women should talk to their doctors sooner. Women in their 30s who've been trying to get pregnant for six months should speak to their doctors as soon as possible. A woman's chances of having a baby decrease rapidly every year after the age of 30. So getting a complete and timely fertility evaluation is especially important.

Some health issues also increase the risk of fertility problems. So women with the following issues should speak to their doctors as soon as possible:

irregular periods or no menstrual periods
very painful periods
endometriosis
pelvic inflammatory disease
more than one miscarriage

No matter how old you are, it's always a good idea to talk to a doctor before you start trying to get pregnant. Doctors can help you prepare your body for a healthy baby. They can also answer questions on fertility and give tips on conceiving.

How will doctors find out if a woman and her partner have fertility problems?

Sometimes doctors can find the cause of a couple's infertility by doing a complete fertility evaluation. This process usually begins with physical exams and health and sexual histories. If there are no obvious problems, like poorly timed intercourse or absence of ovulation, tests will be needed.

Finding the cause of infertility is often a long, complex and emotional process. It can take months for you and your doctor to complete all the needed exams and tests. So don't be alarmed if the problem is not found right away.

For a man, doctors usually begin by testing his semen. They look at the number, shape, and movement of the sperm. Sometimes doctors also suggest testing the level of a man's hormones.

For a woman, the first step in testing is to find out if she is ovulating each month. There are several ways to do this. A woman can track her ovulation at home by:

recording changes in her morning body temperature (basal body temperature) for several months
recording the texture of her cervical mucus for several months
using a home ovulation test kit (available at drug or grocery stores)

Doctors can also check if a woman is ovulating by doing blood tests and an ultrasound of the ovaries. If the woman is ovulating normally, more tests are needed.

Some common tests of fertility in women include:

Hysterosalpingography: In this test, doctors use x-rays to check for physical problems of the uterus and fallopian tubes. They start by injecting a special dye through the vagina into the uterus. This dye shows up on the x-ray. This allows the doctor to see if the dye moves normally through the uterus into the fallopian tubes. With these x-rays doctors can find blockages that may be causing infertility. Blockages can prevent the egg from moving from the fallopian tube to the uterus. Blockages can also keep the sperm from reaching the egg.
Laparoscopy: During this surgery doctors use a tool called a laparoscope to see inside the abdomen. The doctor makes a small cut in the lower abdomen and inserts the laparoscope. Using the laparoscope, doctors check the ovaries, fallopian tubes, and uterus for disease and physical problems. Doctors can usually find scarring and endometriosis by laparoscopy.

How do doctors treat infertility?

Infertility can be treated with medicine, surgery, artificial insemination or assisted reproductive technology. Many times these treatments are combined. About two-thirds of couples who are treated for infertility are able to have a baby. In most cases infertility is treated with drugs or surgery.

Doctors recommend specific treatments for infertility based on:

test results
how long the couple has been trying to get pregnant
the age of both the man and woman
the overall health of the partners
preference of the partners

Doctors often treat infertility in men in the following ways:

Sexual problems: If the man is impotent or has problems with premature ejaculation, doctors can help him address these issues. Behavioral therapy and/or medicines can be used in these cases.
Too few sperm: If the man produces too few sperm, sometimes surgery can correct this problem. In other cases, doctors can surgically remove sperm from the male reproductive tract. Antibiotics can also be used to clear up infections affecting sperm count.

Various fertility medicines are often used to treat women with ovulation problems. It is important to talk with your doctor about the pros and cons of these medicines. You should understand the risks, benefits, and side effects.

Doctors also use surgery to treat some causes of infertility. Problems with a woman's ovaries, fallopian tubes, or uterus can sometimes be corrected with surgery.

Intrauterine insemination (IUI) is another type of treatment for infertility.IUI is known by most people as artificial insemination. In this procedure, the woman is injected with specially prepared sperm. Sometimes the woman is also treated with medicines that stimulate ovulation before IUI.

IUI is often used to treat:

mild male factor infertility
women who have problems with their cervical mucus
couples with unexplained infertility

What medicines are used to treat infertility in women?

Some common medicines used to treat infertility in women include:

Clomiphene citrate (Clomid): This medicine causes ovulation by acting on the pituitary gland. It is often used in women who have Polycystic Ovarian Syndrome (PCOS) or other problems with ovulation. This medicine is taken by mouth.
Human menopausal gonadotropin or hMG (Repronex, Pergonal): This medicine is often used for women who don't ovulate due to problems with their pituitary gland. hMG acts directly on the ovaries to stimulate ovulation. It is an injected medicine.
Follicle-stimulating hormone or FSH (Gonal-F, Follistim): FSH works much like hMG. It causes the ovaries to begin the process of ovulation. These medicines are usually injected.
Gonadotropin-releasing hormone (Gn-RH) analog: These medicines are often used for women who don't ovulate regularly each month. Women who ovulate before the egg is ready can also use these medicines. Gn-RH analogs act on the pituitary gland to change when the body ovulates. These medicines are usually injected or given with a nasal spray.
Metformin (Glucophage): Doctors use this medicine for women who have insulin resistance and/or Polycystic Ovarian Syndrome (PCOS). This drug helps lower the high levels of male hormones in women with these conditions. This helps the body to ovulate. Sometimes clomiphene citrate or FSH is combined with metformin. This medicine is usually taken by mouth.
Bromocriptine (Parlodel): This medicine is used for women with ovulation problems due to high levels of prolactin. Prolactin is a hormone that causes milk production.

Many fertility drugs increase a woman's chance of having twins, triplets or other multiples. Women who are pregnant with multiple foetuses have more problems during pregnancy. Multiple foetuses have a high risk of being born too early (prematurely). Premature babies are at a higher risk of health and developmental problems.

What is assisted reproductive technology (ART)?

Assisted reproductive technology (ART) is a term that describes several different methods used to help infertile couples. ART involves removing eggs from a woman's body, mixing them with sperm in the laboratory and putting the embryos back into a woman's body.

How often is assisted reproductive technology (ART) successful?

Success rates vary and depend on many factors. Some things that affect the success rate of ART include:

age of the partners
reason for infertility
clinic
type of ART
if the egg is fresh or frozen
if the embryo is fresh or frozen

The US Centers for Disease Prevention (CDC) collects success rates on ART for some fertility clinics. According to the 2003 CDC report on ART, the average percentage of ART cycles that led to a healthy baby were as follows:

37.3% in women under the age of 35
30.2% in women aged 35-37
20.2% in women aged 37-40
11.0% in women aged 41-42

ART can be expensive and time-consuming. But it has allowed many couples to have children that otherwise would not have been conceived. The most common complication of ART is multiple foetuses. But this is a problem that can be prevented or minimized in several different ways.

What are the different types of assisted reproductive technology (ART)?

Common methods of ART include:

In vitro fertilization (IVF) means fertilization outside of the body. IVF is the most effective ART. It is often used when a woman's fallopian tubes are blocked or when a man produces too few sperm. Doctors treat the woman with a drug that causes the ovaries to produce multiple eggs. Once mature, the eggs are removed from the woman. They are put in a dish in the lab along with the man's sperm for fertilization. After 3 to 5 days, healthy embryos are implanted in the woman's uterus.
Zygote intrafallopian transfer (ZIFT) or Tubal Embryo Transfer is similar to IVF. Fertilization occurs in the laboratory. Then the very young embryo is transferred to the fallopian tube instead of the uterus.
Gamete intrafallopian transfer (GIFT) involves transferring eggs and sperm into the woman's fallopian tube. So fertilization occurs in the woman's body. Few practices offer GIFT as an option.
Intracytoplasmic sperm injection (ICSI) is often used for couples in which there are serious problems with the sperm. Sometimes it is also used for older couples or for those with failed IVF attempts. In ICSI, a single sperm is injected into a mature egg. Then the embryo is transferred to the uterus or fallopian tube.

ART procedures sometimes involve the use of donor eggs (eggs from another woman), donor sperm, or previously frozen embryos. Donor eggs are sometimes used for women who can not produce eggs. Also, donor eggs or donor sperm is sometimes used when the woman or man has a genetic disease that can be passed on to the baby.

FOLIC ACID is Pregnancy

noreply@blogger.com (Manzoor Majeed) — Wed, 19 Aug 2009 07:05:00 +0000

What is folic acid?

Folic acid is a B vitamin. Folic acid helps the body make healthy new cells.

Why should women take folic acid?

All women need folic acid. When a woman has enough folic acid before and during pregnancy, it can help prevent major birth defects of her baby's brain or spine.

Be sure to get enough folic acid every day. Start before you are pregnant. Folic acid is needed during the first few weeks, often before a woman knows she is pregnant. And half of all pregnancies in the U.S. are not planned. That is why it's so important to start taking folic acid each day, even when you are not planning to get pregnant.

Folic acid might also have other benefits for men and women of any age. Some studies show that folic acid might help prevent heart disease, stroke, some cancers, and possibly Alzheimer's disease.

How can women get folic acid?

All women should aim to get at least 400 micrograms (400 mcg) of folic acid each day. There are a few easy ways she can do this.

Take a daily vitamin that has folic acid in it. Most multivitamins sold in the U.S. have enough. Check the label on the vitamin to be sure. It should say �400 mcg� or �100%� next to folic acid. Some labels might use the word �folate� for folic acid. Or you can take a vitamin pill that only has folic acid in it. You can find both of these types at your local grocery, drug store, or discount store.

Another way to get enough folic acid is to eat a serving of breakfast cereal that contains 100% of the daily value (DV) for folic acid each day. Check the label on the box to be sure it has enough.

Eat a healthy diet that contains lots of fruits and vegetables and other foods that have folic acid (or folate) in them or added to them. Foods that contain folic acid (or folate) include broccoli, asparagus, bananas, oranges, peas, nuts, bread, cereal, and flour.

How much folic acid should you take?

Read the descriptions below to see how much folic acid you should take. Check off the one that applies to you.

	You are able to get pregnant. Take 400 mcg of folic acid every day.
	You are pregnant. Take 600mcg of folic acid every day.
	You are breastfeeding. Take 500mcg of folic acid every day.
	You had a baby with spina bifida or anencephaly and want to get pregnant again. Talk with your doctor, and ask for a prescription for a higher dose of folic acid. You should take 4,000 micrograms (4,000 mcg) starting at least one to three months before getting pregnant and during the first 3 months of pregnancy. That's 10 times the normal amount! But don't try to get the larger amount by taking more than one multivitamin or prenatal vitamin a day. You could get too much of another vitamin that could harm you or your baby.
	You had a baby with spina bifida or anencephaly. You are not planning to have another baby. Take 400 mcg of folic acid every day.

What is Ectopic Pregnancy

noreply@blogger.com (Manzoor Majeed) — Wed, 19 Aug 2009 07:04:00 +0000

An ectopic pregnancy is one in which the fertilized ovum is implanted in any tissue other than the uterine wall. Most ectopic pregnancies occur in the Fallopian tube (so-called tubal pregnancies), but implantation can also occur in the cervix, ovaries, and abdomen.

An Overview of ectopic pregnancy

In a normal pregnancy, the fertilized egg enters the uterus and settles into the uterine lining where it has plenty of room to divide and grow. About 1% of pregnancies are in an ectopic location with implantation not occurring inside of the womb, and of these 98% occur in the Fallopian tubes.

In a typical ectopic pregnancy, the embryo does not reach the uterus, but instead adheres to the lining of the Fallopian tube. The implanted embryo burrows actively into the tubal lining. Most commonly this invades vessels and will cause bleeding. This bleeding expels the implantation out of the tubal end as a tubal abortion. Some women thinking they are having a miscarriage are actually having a tubal abortion. There is no inflammation of the tube in ectopic pregnancy. The pain is caused by prostaglandins released at the implantation site, and by free blood in the peritoneal cavity, which is locally irritant. Sometimes the bleeding might be heavy enough to threaten the health or life of the woman. Usually this degree of bleeding is due to delay in diagnosis, but sometimes, especially if the implantation is in the proximal tube (just before it enters the uterus), it may invade into Sampson's artery, causing heavy bleeding earlier than usual.

If left untreated, about half of ectopic pregnancies will resolve without treatment. These are the tubal abortions. The advent of methotrexate treatment for ectopic pregnancy has reduced the need for surgery; however, surgical intervention is still required in cases where the Fallopian tube has ruptured or is in danger of doing so. This intervention may be laparoscopic or through a larger incision, known as a laparotomy.

What causes an ectopic pregnancy

The cause of ectopic pregnancy is unknown. After fertilization of the oocyte in the peritoneal cavity, the egg takes about nine days to migrate down the tube to the uterine cavity at which time it implants. Wherever the embryo finds itself at that time, it will begin to implant.

There are some speculative specific causes or associations. Smoking, advanced maternal age and prior tubal damage of any origin are well shown risk factors for ectopic pregnancy.

Cilial damage and tube occlusion

Hair-like cilia located on the internal surface of the Fallopian tubes carry the fertilized egg to the uterus. Damage to the cilia or blockage of the Fallopian tubes is likely to lead to an ectopic pregnancy. Women with pelvic inflammatory disease (PID) have a high occurrence of ectopic pregnancy. This results from the build-up of scar tissue in the Fallopian tubes, causing damage to cilia. If however both tubes were occluded by PID, pregnancy would not occur and this would be protective against ectopic pregnancy. Tubal surgery for damaged tubes might remove this protection and increase the risk of ectopic pregnancy. Tubal ligation can predispose to ectopic pregnancy. Seventy percent of pregnancies after tubal cautery are ectopic, while 70% of pregnancies after tubal clips are intrauterine. Reversal of tubal sterilization carries a risk for ectopic pregnancy. This is higher if more destructive methods of tubal ligation (tubal cautery, partial removal of the tubes) have been used than less destructive methods (tubal clipping). A history of ectopic pregnancy increases the risk of future occurrences to about 10%. This risk is not reduced by removing the affected tube, even if the other tube appears normal.

Excessive oestrogen and progesterone

There has been speculation about the role of hormones in the genesis of ectopic pregnancy. No proven association has been established. High levels of oestrogen and progesterone are thought possibly to increase the risk of ectopic pregnancy because these hormones slow the movement of the fertilized egg through the Fallopian tube. However, advancing age is a risk factor for ectopic pregnancy, although this is a period of declining hormone levels.

Role of intrauterine devices (IUD)

The use of intrauterine devices (IUDs) was thought at one time to increase the risk of ectopic pregnancy. However the older model copper based IUDs were only effective in preventing intrauterine pregnancies, not tubal pregnancies. As the IUD is effective in reducing pregnacy overall, the relative risk only of ectopic is increased. The old copper-based IUDs reduced the overall pregnancy rate so effectively that even the gross ectopic rates were reduced. Nonetheless any pregnancy conceived with an IUD in situ must be investigated to exclude possible ectopic pregnancy.

The newer hormone-based (levonorgestrel) IUS creates such a profound suppression of the endometrium that overall pregnancy rate is lower even than that of male or female sterilization. There are some data available for ectopic pregnancy with the IUS, but the relative risk is extremely low, around 0.01%.

Association with infertility

Infertility treatments are highly variable and specific to individual patients. IVF is used for patients with damaged tubes which are an inherent risk factor for ectopic. Ectopic pregnancies have been seen with In Vitro Fertilization, but is uncommon and quickly diagnosed by the early ultrasounds that these intensively surveyed patients undergo.

Other

Patients are at higher risk for ectopic pregnancy with advancing age. Also, it has been noted that smoking is associated with ectopic risk. Vaginal douching is thought by some to increase ectopic pregnancies. Women exposed to diethylstilbestrol (DES) in utero (aka "DES Daughters") also have an elevated risk of ectopic pregnancy, up to 3 times the risk of unexposed women.

What are the symptoms of an ectopic pregnancy

Early symptoms are either absent or subtle. Clinical presentation of ectopic pregnancy occurs at a mean of 7.2 weeks after the last normal menstrual period, with a range of 5 to 8 weeks. Later presentations are more common in communities deprived of modern diagnostic ability.

The early signs are:

Pain and discomfort, usually mild. A corpus luteum on the ovary in a normal pregnancy may give very similar symptoms.

Vaginal bleeding, usually mild. An ectopic pregnancy is usually a failing pregnancy and falling levels of progesterone from the corpus luteum on the ovary cause withdrawal bleeding. This can be indistinguishable from an early miscarraige or the 'implantation bleed' of a normal early pregnancy.

Patients with a late ectopic pregnancy typically have pain and bleeding. This bleeding will be both vaginal and internal and has two discrete pathophysiologic mechanisms.

External bleeding is due to the falling progesterone levels.

Internal bleeding is due to hemorrhage from the affected tube.

The differential diagnosis at this point is between miscarriage, ectopic pregnancy, and early normal pregnancy. The presence of a positive pregnancy test virtually rules out pelvic infection as it is rare indeed to find pregnancy with an active Pelvic Inflammatory Disease (PID). The most common misdiagnosis assigned to early ectopic pregnancy is PID.

More severe internal bleeding may cause:

Lower back, abdominal, or pelvic pain.
Shoulder pain. This is caused by free blood tracking up the abdominal cavity, and is an ominous sign.
There may be cramping or even tenderness on one side of the pelvis.
The pain is of recent onset, meaning it must be differentiated from cyclical pelvic pain, and is often getting worse.

Ectopic pregnancy is noted that it can mimic symptoms of other diseases such as appendicitis, other gastrointestinal disorder, problems of the urinary system, as well as pelvic inflammatory disease and other gynaecologic problems.

How is an ectopic pregnancy diagnosed ?

An ectopic pregnancy has to be suspected in any woman with lower abdominal pain and/or unusual bleeding who is or might be sexually active and whose pregnancy test is positive. And abnormal rise in blood hCG levels may also indicate an ectopic pregnancy. The threshold of discrimination of intrauterine pregnancy today is around 3000 IU/ml of Human Chorionic Gonadotropin (HCG). A high resolution, vaginal ultrasound scan showing no intrauterine pregnancy is presumptive evidence that an ectopic pregnancy is present if the threshold of discrimination for HCG has been reached. An empty uterus with levels lower than 3000IU/ml may be evidence of an ectopic pregnancy, but may also be consistent with an intrauterine pregnancy which is simply too small to be seen on ultrasound. If there is uncertainty it might be necessary to wait a few days and repeat the bloodwork and ultrasound.

An ultrasound showing a gestational sac with foetal heart is clear evidence of ectopic pregnancy.

Free fluid which is non echogenic is a normal finding in the late menstrual cycle and early normal pregnacy. This is a transudate and is not presumptive evidence of bleeding. Echogenic free fluid suggests the presence of blood clot and is suggestive of free blood in the peritoneum.

A laparoscopy or laparotomy can also be performed to visually confirm an ectopic pregnancy. Often if a tubal abortion has occurred, or a tubal rupture has occurred, it is hard actually to find the pregnancy tissue. Laparoscopy in very early ectopic pregnancy may rarely show a normal looking Fallopian tube.

Nontubal ectopic pregnancy

2% of ectopic pregnancies occur in the ovary, cervix, or are intraabdominal. Transvaginal ultrasound examination is usually able to detect a cervical pregnancy. An ovarian pregnancy is differentiated from a tubal pregnancy by the Spiegelberg criteria.

While a foetus of ectopic pregnancy is typically not viable, very rarely, an abdominal pregnancy has been salvaged. In such a situation the placenta sits on the intraabdominal organs or the peritoneum and has found sufficient blood supply. In this author's experience this is invariably bowel or mesentery, but other sites, such as the renal (kidney), liver or hepatic (liver) artery or even aorta have been described. Support to near viability has occasionally been described, but even in third world countries, the diagnosis is most commonly made at 16 to 20 weeks gestation. Such a foetus would have to be delivered by laparotomy. Maternal morbidity and mortality from extrauterine pregnancy is high as attempts to remove the placenta from the organs to which it is attached usually lead to uncontrollable bleeding from the attachment site. If the organ to which the placenta is attached is removable, such as a section of bowel, then the placenta should be removed together with that organ. This is such a rare occurrence that true data are unavailable and reliance must be made on anecdotal reports. However, the vast majority of abdominal pregnancies require intervention well before fetal viability because the risk of hemorrhage.

Treatment of ectopic pregnancy

Nonsurgical treatment

Early treatment of an ectopic pregnancy with the drug methotrexate has proven to be a viable alternative to surgical treatment since 1993. If administered early in the pregnancy, methotrexate can disrupt the growth of the developing embryo causing the cessation of pregnancy.

Surgical treatment

If haemorrhaging has already occurred, surgical intervention may be necessary if there is evidence of ongoing blood loss. However, as already stated, about half of ectopics result in tubal abortion and are self limiting. The option to go to surgery is thus often a difficult decision to make in an obviously stable patient with minimal evidence of blood clot on ultrasound.

Surgeons use laparoscopy or laparotomy to gain access to the pelvis and can either incise the affected Fallopian and remove only the pregnancy (salpingostomy) or remove the affected tube with the pregnancy (salpingectomy).

Chances of future pregnancy after an ectopic pregnancy

The chance of future pregnancy depends on the status of the tube(s) that are left behind, but is decreased. The chance of recurrent ectopic pregnancy is about 10% and is independent of whether the affected tube was repaired (salpingostomy) or removed (salpingectomy). Successful pregnancy rates vary widely between different centres, and appear to be operator dependent. Pregnancy rates with successful methotrexate treatment compare favourably with the highest reported pregnancy rates. Often, patients may have to resort to IVF to achieve a successful pregnancy. The use of IVF does not preclude further ectopic pregnancies, but the likelihood is reduced.

Complications with ectopic pregnancy

The most common complication is rupture with internal bleeding that leads to shock. Death from rupture is rare. Infertility occurs in 10 - 15% of women who have had an ectopic pregnancy.

Down's Syndrome Explained

noreply@blogger.com (Manzoor Majeed) — Wed, 19 Aug 2009 07:03:00 +0000

What is Down's Syndrome?

Down's syndrome is set of mental and physical symptoms that result from having an extra copy of Chromosome 21.

Normally, a fertilized egg has 23 pairs of chromosomes. In most people with Down syndrome, there is an extra copy of Chromosome 21 (also called trisomy 21 because there are three copies of this chromosome instead of two), which changes the body's and brain's normal development.

What are the signs and symptoms of Down syndrome?

Even though people with Down syndrome may have some physical and mental features in common, symptoms of Down syndrome can range from mild to severe. Usually, mental development and physical development are slower in people with Down syndrome than in those without the condition.

Mental retardation is a disability that causes limits on intellectual abilities and adaptive behaviors (conceptual, social, and practical skills people use to function in everyday lives). Most people with Down syndrome have IQs that fall in the mild to moderate range of mental retardation. They may have delayed language development and slow motor development.

Some common physical signs of Down syndrome include:

Flat face with an upward slant to the eye, short neck, and abnormally shaped ears
Deep crease in the palm of the hand
White spots on the iris of the eye
Poor muscle tone, loose ligaments
Small hands and feet

There are a variety of other health conditions that are often seen in people who have Down syndrome, including:

Congenital heart disease
Hearing problems
Intestinal problems, such as blocked small bowel or oesophagus
Celiac disease
Eye problems, such as cataracts
Thyroid dysfunctions
Skeletal problems
Dementia�similar to Alzheimer's

What is the treatment for Down syndrome?

Down syndrome is not a condition that can be cured. However, early intervention can help many people with Down syndrome live productive lives well into adulthood.

Children with Down syndrome can often benefit from speech therapy, occupational therapy, and exercises for gross and fine motor skills. They might also be helped by special education and attention at school. Many children can integrate well into regular classes at school.

Who is at risk for Down syndrome?

The chance of having a baby with Down syndrome increases as a woman gets older�from about 1 in 1,250 for a woman who gets pregnant at age 25, to about 1 in 100 for a woman who gets pregnant at age 40. But, most babies with Down syndrome are born to women under age 35 because more younger women have babies.

Because the chances of having a baby with Down syndrome increase with the age of the mother, many health care providers recommend that women over age 35 have prenatal testing for the condition. Testing the baby before it is born to see if he or she is likely to have Down syndrome allows parents and families to prepare for the baby's special needs.

Parents who have already have a baby with Down syndrome or who have abnormalities in their own chromosome 21 are also at higher risk for having a baby with Down Syndrome.

Once the baby is born, a blood test can confirm whether the baby has Down syndrome.

Donor Insemination Explained

noreply@blogger.com (Manzoor Majeed) — Tue, 18 Aug 2009 10:53:00 +0000

What is donor insemination?

Donor insemination is where semen from a donor is artificially inseminated into a woman who wishes to conceive (ie. have a baby) but does not have a fertile male partner.

Artificial insemination is when sperm is placed into the uterus or cervix of a female by using artificial means.

Artificial insemination

In humans artificial insemination is usually part of an infertility treatment; either the woman's partner's sperm (artificial insemination by husband, AIH) or donor sperm (artificial insemination by donor) can be used.

The woman's menstrual cycle is closely observed, using ovulation kits, ultrasounds or blood tests. When an ovum is released, semen from a donor is inserted into her body. Just as with in vitro fertilization, the male donor is recommended not to ejaculate for a few days before the procedure. This is to ensure a higher sperm count. After the donation the sperm must immediately be �washed� in a laboratory. The process of �washing� the sperm increases the chances of fertilization and removes any chemicals in the semen that may cause discomfort for the woman. A chemical is added to the sperm that will separate the most active sperm in the sample. If the procedure is successful, she conceives and bears to term a baby as normal, making her both the genetic and gestational mother.

Of course, there are various gradations of treatment, and more technical procedures are sometimes needed. For example, semen can be injected directly into a woman's uterus to improve the chance of conception in a process called intrauterine insemination.

Artificial insemination has become a significant issue in recent years, particularly in debates revolving around surrogate parenting. Legal issues have arisen in cases where the gestational (and possibly genetic) mother decides to keep the child. Likewise, there have been debates over the rights of sperm donors.

Chorionic Villus Sampling (CVS) Details

noreply@blogger.com (Manzoor Majeed) — Tue, 18 Aug 2009 10:51:00 +0000

In chorionic villus sampling (CVS), the doctor collects a small piece of tissue from the placenta using a needle passed through the mother’s vagina and cervix. The placenta has the same genetic makeup as the baby.

Most healthy women do not need all the tests. Ultrasound examinations during pregnancy are routine, although they are not always required and rarely influence treatment decisions. Amniocentesis and CVS are recommended only when a risk of genetic problems exists because of family history or something detected during an ultrasound. Amniocentesis and CVS carry a slight risk of harming the baby and mother, or ending the pregnancy in miscarriage, so those risks should be weighed carefully against the potential benefits of learning about the baby’s condition. .

Amniocentesis, the removal and analysis of a small sample of foetal cells from the amniotic fluid, is widely available and involves a lower risk of miscarriage than chorionic villus sampling. However, amniocentesis cannot be done until the 14th to 18th week of pregnancy.

Chorionic villus sampling, conducted at 9 to 11 weeks of pregnancy, involves extracting a tiny amount of chorionic villi, tissue extensions that will eventually develop into a placenta. The villi can be obtained through the pregnant woman's abdomen or cervix. This type of sampling carries a 1-2% risk of miscarriage.

A third diagnostic method, percutaneous umbilical blood sampling or PUBS, is the most accurate method in detecting Down's syndrome and can be used to confirm the results of CVS or amniocentesis. However, PUBS cannot be performed until later in the pregnancy, during the 18th to 22nd weeks, and carries the greatest risk of miscarriage. Extra care should be taken in this time and if need be contact your doctor at once.

Birth Defects Explained

noreply@blogger.com (Manzoor Majeed) — Tue, 18 Aug 2009 10:51:00 +0000

What are birth defects?

Birth defects are structural or functional abnormalities present at birth that cause physical or mental disability. Some may be fatal.

Researchers have identified thousands of different birth defects. Currently, birth defects are the leading cause of death for infants during the first year of life.

What causes birth defects?

Birth defects have a variety of causes, such as:

Genetic problems caused when one or more genes doesn't work properly or part of a gene is missing

Problems with chromosomes, such as having an extra chromosome or missing part of a chromosome

Environmental factors that a woman is exposed to during pregnancy, such as rubella or German measles while pregnant, or using drugs or alcohol during pregnancy

What are the different types of birth defects?

There are two main types of birth defects: structural and functional/developmental.

Structural birth defects are related to a problem with body parts. Some physical problems include cleft lip or cleft palate, heart defects, such as missing or misshaped valves, and abnormal limbs, such as a club foot. They also include neural tube defects, such as spina bifida, problems that are related to the growth and development of the brain and spinal cord.

Functional birth defects are related to a problem with how a body part or body system works. These problems often lead to developmental disabilities and can include things such as:

Nervous system or brain problems - such as learning disabilities, mental retardation, behavioral disorders, speech or language difficulties, convulsions, and movement trouble. Some examples of birth defects that affect the nervous system include Autism, Down syndrome, Prader-Willi syndrome, and Fragile X syndrome.

Sensory problems - such as blindness, cataracts and other visual problems, and varying degrees of hearing loss including deafness

Metabolic disorders - involve a body process or chemical pathway or reaction, such as conditions that limit the body's ability to get rid of waste materials or harmful chemicals. Two common metabolic disorders are phenylketonuria (PKU) and hypothryroidsim.

Degenerative disorders--are conditions that might not be obvious at birth, but cause one or more aspects of health to steadily get worse. For example, X-linked adrenoleukodystrophy (X-ALD), which was the focus of the movie Lorenzo's Oil, Rett syndrome, muscular dystrophy, and lysosomal disorders are examples of degenerative disorders.

In some cases, birth defects are caused by a combination of factors. Some recognized patterns of birth defects affect many parts or processes in the body, leading to both structural and functional problems.

Amniocentesis

noreply@blogger.com (Manzoor Majeed) — Tue, 18 Aug 2009 10:50:00 +0000

In amniocentesis, the doctor inserts a needle through the mother’s skin into the amniotic sac to collect about an ounce of amniotic fluid. The fluid contains genetic material from the baby that can be analyzed for signs of defects.

Most healthy women do not need all the tests. Ultrasound examinations during pregnancy are routine, although they are not always required and rarely influence treatment decisions. Amniocentesis and Chorionic Villus Sampling (CVS) are recommended only when a risk of genetic problems exists because of family history or something detected during an ultrasound. Amniocentesis and CVS carry a slight risk of harming the baby and mother, or ending the pregnancy in miscarriage, so those risks should be weighed carefully against the potential benefits of learning about the baby’s condition.

PREGNANCY & BIRTH

noreply@blogger.com (Manzoor Majeed) — Tue, 18 Aug 2009 10:49:00 +0000

This section looks at issues relating to pregnancy, labour and child birth.

AMNIOCENTISIS

Pregnant women over 35 should consider whether to have an amniocentisis to test for foetal abnormalities. This article details the procedure, the risks and benefits.

BIRTH DEFECTS

Birth defects are abnormalities present at birth that cause physical or mental disability. This article looks at causes and types of birth defect.

CHORIONIC VILLUS SAMPLING (CVS)
CVS is a test on the placenta to check for possible genetic abnormalities in the foetus. This article looks at how the test is performed and the risks of the procedure.

DONOR INSEMINATION
Donor insemination offers the hope of a pregnancy for some infertile couples. This article outlines the procedure and the legal issues related to it.

DOWN'S SYNDROME

This article outlines the age-related risk of having a baby with Down's syndrome, and the features of this genetic condition.

ECTOPIC PREGNANCY

This is a potentially life-threatening condition of early pregnancy and all women should be aware of the symptoms. Modern treatment aims to preserve future fertility.

FOLIC ACID

Folic acid has been shown to reduce the incidence of spina bifida when taken before conception and in early pregnancy. This article profiles the supplement.

GLOSSARY OF TERMS USED IN ASSISTED REPRODUCTIVE TECHNOLOGY
This article explains the technical terms and jargon used during infertility treatment, and is a helpful guide for those undergoing or considering treatment.

INFERTILITY

Infertility is experienced by an estimated 10 percent of couples. This article looks at some of the causes and when to seek expert help.

IVF (IN VITRO FERTILISATION) AND GIFT (GAMETE INTRA FALLOPIAN TRANSFER)
IVF and GIFT offer hope of a genetic child to many infertile couples. This article outlines how the procedures are carried out, and their success rates.

LISTERIA

This is a food-borne illness which is dangerous for pregnant women and those with weak immune systems. This article profiles the illness and how to minimise your risk of getting it.

MALE INFERTILITY

This article discusses the latest technology in treatment options for male infertility, including the Intracytoplasmic Sperm Injection and donor insemination.

MALE INFERTILITY TREATMENT OPTIONS
The development of Intracytoplasmic Sperm Injections (ICSI) has offered hope of a genetic child to infertile men. This article outlines this treatment and other options for infertile men.

MEDICATION IN PREGNANCY

This article provides a useful overview of the issues about medication use during pregnancy.

MISCARRIAGE

A miscarriage is a distressing event for many couples. This article looks at why they occur and the theories behind recurrent miscarriage.

PAIN RELIEF IN LABOUR
This article provides a broad overview of the different methods of pain relief that can be used during child birth.

POST NATAL DEPRESSION
An estimated 10 percent of new mothers get post natal depression. This article outlines the theories behind the disorder and what can be done to help.

PRE-ECLAMPSIA

Pre-eclampsia is a condition related to increased blood pressure and protein in the mother's urine. This article looks at the risks related to the condition.

PREGNANCY OVERVIEW

A normal pregnancy can still involve some undesirable symptoms like nausea and back pain. This article offers an overview of a healthy pregnancy.

RUBELLA

German measles is normally a mild illness but is serious in pregnant women because of the risks of birth defects. This article provides an overview of the illness.

SLAPPED CHEEK DISEASE (FIFTH DISEASE)
Slapped cheek disease is a mild illness among children but can be serious in pregnancy. This article looks at the symptoms and what can be done to help.

TOXOPLASMOSIS

Toxoplasmosis is an infection carried by cats that can be dangerous in pregnancy. This article looks at the risks of infection.

ULTRASOUND SCANNING

Ultrasound scanning is a common diagnostic technique. It is often used during pregnancy and to diagnose medical problems. This article outlines how the scan is performed and what preparation is required.

VASECTOMY REVERSAL

A small percentage of men will seek a vasectomy reversal. This article discusses the operation and the success rates.

How much does cosmetic surgery cost?

noreply@blogger.com (Manzoor Majeed) — Fri, 07 Aug 2009 23:09:00 +0000

Cosmetic surgery is cheaper than it used to be and has become affordable for a great many people.

However, prices vary according to the procedure. The more complicated and extensive the procedure the more expensive it is likely to be. Many sites do not list prices on their site as they state that each procedure, surgeon and hospital is different and will, of course, charge different prices.

One of the most common questions when it comes to cosmetic surgery is, what is the price? how much does it cost? why are some clinics cheaper than others?

The overall cost of any cosmetic surgery procedure ultimately depends on a number of different factors including but not limited to:

The experience of the surgeon
The Location of the Clinic
The aftercare package that you get
The type of procedure you are having
The type or quality of materials being used (eg implant type)
The number of days in hospital required

To get an idea of the cost of your cosmetic surgery it is better to arrange a free, no-obligation consultation with a surgeon in which you will be given a quote. This exact quote should include surgeon’s fees, anaesthetist’s fees, clinic/hospital care and aftercare. This means you will know exactly what you are paying for.

As a rough guide though, you are looking at paying £3,500 to £5,000 for breast augmentation; £3,000 to £4,000 for rhinoplasty and £2,800 to £3,500 for blepharoplasty. And I am saying it again a Rough guide, as prices may vary is different countries as well as for doctors fees and hospital fees!

In respect of paying for your surgery you have several options. You can either pay for it yourself or you can take out a loan to cover the cost. The loan can either be a personal loan from your local bank or building society or obtained through a finance scheme.

Many cosmetic surgery providers will operate a finance scheme which enables you to take out a loan to cover the cost of your treatment. Another option is a specialist medical loans provider.

If you have private health insurance then note that cosmetic surgery usually appears on their list of ‘exclusions’. They will only pay out for treatment which is considered a ‘medical necessity’.