Paul Dobson's Research

Worst. Certificate. Ever

2012-02-08T21:19:00.000Z


The course was very good though	.

The Golden Age of the Idler

2012-01-29T23:23:00.000Z

The essence of Idling is to swap about 'Work Ethic' and 'Idle' such that the former becomes perjorative and the latter a virtue. To what end? "When we have nothing to do, we cannot avoid thinking about things. When we are idle, our minds leap into action".^ref

Trees, growing beautifully, "for they have nothing else to do". Credit

I think this true, for a subset of people at least. Is it not best to leave Turings, Russells, Wittgensteins, Van Goghs and their ilk to their musings? Should an Andalusian horse pull a dray?

Once we left the important work of idleness to the wealthy, but soon it became clear that their minds weren't up to it, so we formalised it, made universities, and gave better minds support to be professionally idle. Again, idleness is not fecklessness, it is freedom to think and do what these minds could not if burdened by the mundanity of work and money. A university lecturer, therefore, has only two roles: to do the unexpected, and to prepare the next generation to do likewise. All else tumbles from this setup like golden eggs.

Then we broke it. We let our professors talk like middle managers, our teaching become curriculumcised and routine, money is the new god, and corporation-speak of "core values" crept in. Academics crawled into niches that very few now ever truly look beyond. Asking daft questions, wandering around in a world of ideas, and turning over rocks on the way, with a child-like curiosity, is not something to be hurried.

One of my favourite quotes is from Sanderson, headmaster of Oundle, who pronounced himself possessed "of a Dionysian urge to create". A true academic reconciles such an urge with the insouciance of an untroubled, unhurried but brilliant mind, towards matured, quality thoughts that are worth having. How can one think Grand Thoughts to a deadline?

Of course, this is idealistic, dreamy nonsense that may never have been - Merrie Oxbridge, if you will. The expectation that research produces results, even commercially useful ones at present, is not so unreasonable. Yet I cannot believe that rushing is conducive to quality thinking, or that the sorts of minds the more corporate system selects are always all that high wattage.

And, quite appropriately I feel, I shall not strive for some synthesis of these vague thoughts towards a profound conclusion, because they aren't going that way just yet. All in good time...

Much credit due to Stephen Robin's immense collection of idle quotes "The Importance of Being Idle".

All Quiet On The Dobson Front

2011-12-21T23:38:00.003Z

The old blog hasn't been updated much of late. I never quite grasped beforehand how much time and energy a baby would demand. Still, he is marvellous, look...

The Fuzzy Pink Monkey

As we reach the Winter Solstice - a time of year when I particularly love being a Northern European (reindeer, big jumpers, Dickens, German markets, snow, hot chocolatl) - I too intend to turn a corner and post more often.

To begin the resurrection, here's a link to a research brochure about where I work, written by myself. ChELSI (Chemical Engineering at the Life Science Interface) is an institute within the Department of Chemical and Biological Engineering at the University of Sheffield, UK. It was officially opened in November 2011 by Professor Richard Dawkins.

For the launch I was given the job of summarising all ChELSI research and compiling it into a snazzy little brochure. It was extremely difficult (I only had a few weeks to do it), but I really picked up a lot of stuff from other fields, made some new contacts, raised my profile in the department and, hopefully, earned a lot of Brownie points. Richard (we're on first name terms now, honest) described it as "this marvellous little brochure", which was what my PhD supervisor might call a gruntling experience.

In ChELSI I'm working towards improved biomanufacturing hosts through modelling (FBA, kinetic models and pattern recognition). Yet, as ever for the poor postdoc, just as everything gets up to full speed, the sands of time begin to run out. I have six months left. Short contracts are easily the worst thing about being a postdoc. I'm making a deliberate effort not to dwell on it - that way lies madness - but it's a constant worry.

Have yourself a merry little Christmas.

Genome-wide assessment of the carriers involved in the cellular uptake of drugs: a model system in yeast.

2011-10-26T10:05:00.000+01:00

Karin Lanthaler, Elizabeth Bilsland, Paul D Dobson, Harry J Moss, Pinar Pir, Douglas B Kell and Stephen G Oliver

BMC Biology. 2011

Go to article

Abstract

Background
The uptake of drugs into cells has traditionally been considered to be predominantly via passive diffusion through the bilayer portion of the cell membrane. The recent recognition that drug uptake is mostly carrier-mediated, raises the question of which drugs use which carriers.

Results
To answer this, we have constructed a chemical genomics platform built upon the yeast gene deletion collection using competition experiments in batch fermenters and robotic automation of cytotoxicity screens, including protection by 'natural' substrates. Using these, we tested 26 different drugs and identified the carriers required for 18 of the drugs to gain entry into yeast cells.

Conclusions
As well as providing a useful platform technology, these results further substantiate the notion that the cellular uptake of pharmaceutical drugs normally occurs via carrier-mediated transport and indicates that establishing the identity and tissue distribution of such carriers should be a major consideration in the design of safe and effective drugs.

Clouds of Drugs

2011-07-14T13:10:00.007+01:00

I've been doing a bit of primitive database mining for my drug transporter work. I took drugs and synonyms from DrugBank, and transporter genes and synonyms from HGNC, searched against PubMed and calculated some simple co-occurrence statistics.

Wordle tag cloud for drugs that co-occur with SLC15A1 (peptide transporter)

I'll be doing other stuff with the data, but while it was there it was simple enough to throw it into Wordle to get a nice overview of the drugs that occur most frequently in the literature associated with a given transporter. Above is the example of SLC15A1 (a peptide transporter). Valaciclovir is large because it is mentioned in many SLC15A1 papers, whereas Cidofovir is mentioned in fewer. These counts are also normalised by a background of how many PubMed hits each drug has on its own (so a drug that crops up in thousands of papers carries less weight than one that is only mentioned dozens of times, because the latter was less likely than the former to co-occur with the transporter by chance alone).

Note that you have to be careful about interpreting the numbers. Sometimes a drug is mentioned a lot because it is studied a lot, not because it is a particularly important transporter substrate. Sometimes DrugBank includes things that aren't what everyone would call a drug. Sometimes my synonym lists are rubbish. Sometimes I mangled the text. Sometimes a match occurs for some other reason (particularly amino acids, which might pop up because they are being discussed in the context of the protein, for example).

The buttons below take you to your own Wordle tag clouds for each transporter based upon my data ("gene (number of drugs)"). Note I cut off any transporter with fewer than ten drugs because they make for boring word clouds. Also note Wordle truncates to 150 words, but you can edit this via >Layout>Maximum Words

Succimer L-Asparagine Dapsone Becaplermin Baclofen Alpha-1-proteinaseinhibitor Collagenase Sulfisoxazole Glycine Menadione Mannitol Fosinopril Vidarabine Inulin Creatine Oprelvekin L-GlutamicAcid L-GlutamicAcid Nitrofurazone Streptozocin Streptozocin Streptozocin Glutathione Deferoxamine Meclizine Latanoprost L-Leucine L-Glutamine Doxapram Rifabutin Somatropinrecombinant Carbachol Rofecoxib Reteplase Sargramostim Penciclovir Pyruvicacid Pyruvicacid Loxapine Loxapine Sulindac Ziprasidone Mirtazapine L-AsparticAcid Amoxapine Brimonidine L-Tryptophan VitaminC CoagulationFactorIX Clozapine AminosalicylicAcid AminosalicylicAcid Oxyphenonium Ritonavir Nelfinavir Alitretinoin Pentobarbital L-Cystine Ketorolac Pegvisomant Megestrol Secobarbital L-Isoleucine Antithymocyteglobulin L-Cysteine Valsartan Raltitrexed Clemastine Clemastine Nateglinide Tenecteplase Idoxuridine Doxazosin Losartan Denileukindiftitox Benazepril Alpha-LinolenicAcid Flurazepam Ethosuximide Indinavir Indinavir Cladribine Anistreplase Troglitazone Troglitazone Troglitazone Alteplase Olanzapine Palifermin Hyoscyamine Thioguanine Trandolapril Trandolapril L-Threonine Methimazole L-Phenylalanine Acarbose Metformin Metformin L-Proline Glimepiride Glimepiride Glimepiride Rosiglitazone Rosiglitazone L-Carnitine L-Carnitine Anakinra Anakinra Medrysone Lisuride Liothyronine Fluphenazine N-Acetyl-D-glucosamine Ergocalciferol Milrinone

Efavirenz Efavirenz Efavirenz Efavirenz Efavirenz Pemetrexed Pemetrexed Pemetrexed Pemetrexed Pemetrexed Pemetrexed Calcitriol Calcitriol Dapsone Dapsone Dapsone Lactulose Lactulose Baclofen Baclofen Baclofen Collagenase FolicAcid FolicAcid FolicAcid FolicAcid Theophylline Clofarabine Clofarabine Clofarabine Clofarabine Clofarabine Clofarabine Sulfadiazine Sulfadiazine Nafarelin Nafarelin Lidocaine Lidocaine Lindane Lindane Lindane Lindane Oxacillin Oxacillin Oxacillin Succinylcholine Docosanol Docosanol Docosanol Docosanol LipoicAcid LipoicAcid LipoicAcid Entecavir Entecavir Entecavir Entecavir Entecavir Perflutren Perflutren L-Leucine L-Leucine Etanercept Etanercept Etanercept Etanercept BotulinumToxinTypeA BotulinumToxinTypeA BotulinumToxinTypeA BotulinumToxinTypeA Sargramostim Sargramostim Enfuvirtide Enfuvirtide Enfuvirtide Enfuvirtide Enfuvirtide Enfuvirtide Levonorgestrel Levonorgestrel Epoetinalfa Epoetinalfa Epoetinalfa Epoetinalfa Thiopental Nelfinavir Nelfinavir Nelfinavir Nelfinavir Progesterone Progesterone L-Cystine L-Cystine Cinnarizine Carmustine Carmustine L-Isoleucine L-Isoleucine L-Cysteine L-Cysteine Zileuton Zileuton Amiloride Amiloride Tenecteplase Tenecteplase Imiquimod Imiquimod Imiquimod Fenfluramine Fenfluramine Tetracycline Tetracycline Ceftazidime Ceftazidime Ceftazidime Adenine Adenine Methysergide Ibutilide Ibutilide Cladribine Cladribine Cladribine Cladribine Troglitazone Troglitazone Phentolamine Tigecycline Tigecycline Tigecycline Tigecycline Tigecycline Betaxolol Betaxolol Atomoxetine Atomoxetine Bethanidine Bethanidine Mefloquine Mefloquine Mefloquine Esmolol Esmolol Esmolol Estrone Estrone Bupivacaine Bupivacaine Rosiglitazone Rosiglitazone Rosiglitazone L-Carnitine L-Carnitine Methylscopolamine Naftifine Naftifine Naftifine Rituximab Rituximab Rituximab Rituximab Rituximab Rituximab Fluorometholone Fluorometholone NitricOxide NitricOxide Darifenacin Darifenacin Darifenacin Diltiazem Lenalidomide Lenalidomide Lenalidomide Lenalidomide Lenalidomide Lenalidomide Lenalidomide Dexrazoxane Dexrazoxane Pirenzepine Testosterone Testosterone Hexachlorophene Hexachlorophene Flunisolide Flunisolide Alpha-1-proteinaseinhibitor Alpha-1-proteinaseinhibitor Sulfisoxazole Sulfisoxazole Sulfisoxazole Menadione Menadione Pyridostigmine Pyridostigmine Hydroxyzine Hydroxyzine Pamidronate Pamidronate Pamidronate Inulin Inulin Betamethasone Betamethasone Griseofulvin Mitotane Mitotane Mitotane Ipratropiumbromide Ipratropiumbromide Nedocromil Succinicacid Succinicacid Ramipril Ramipril Ramipril Lovastatin Eplerenone Eplerenone Rasburicase Rasburicase Midodrine PyridoxalPhosphate PyridoxalPhosphate Carisoprodol Carisoprodol Carbimazole Carbimazole Mefenamicacid Mefenamicacid Mefenamicacid Mefenamicacid Mefenamicacid Mefenamicacid ValproicAcid ValproicAcid ValproicAcid ValproicAcid ValproicAcid Reteplase Reteplase Metyrosine Methylergonovine Methylergonovine L-Tryptophan L-Tryptophan VitaminC VitaminC Mazindol Amitriptyline Amitriptyline AminosalicylicAcid AminosalicylicAcid AminosalicylicAcid Beclomethasone Beclomethasone Tizanidine Tizanidine Bleomycin Bleomycin Zolpidem Zolpidem Zolpidem Vasopressin Vasopressin Mometasone Mometasone Mometasone Mometasone Sildenafil Sildenafil Sildenafil Butorphanol Esomeprazole Esomeprazole Esomeprazole Esomeprazole CalciumAcetate CalciumAcetate CalciumAcetate Cefotiam Cefotiam Cefotiam Sumatriptan Sumatriptan Sumatriptan Doxylamine Doxylamine Oxiconazole Oxiconazole Oxiconazole Benzquinamide Benzquinamide Benzquinamide Bortezomib Bortezomib Bortezomib Bortezomib Bortezomib Bortezomib Timolol Timolol Lamivudine Lamivudine Lamivudine Lamivudine Oxaliplatin Oxaliplatin Oxaliplatin Oxaliplatin Oxaliplatin Oxaliplatin Eletriptan Eletriptan Tobramycin Tobramycin Aldesleukin Aldesleukin Oseltamivir Oseltamivir Oseltamivir Oseltamivir AntihemophilicFactor AntihemophilicFactor AntihemophilicFactor Modafinil Modafinil Modafinil Modafinil Nitroprusside Nitroprusside Fluorescein Fluorescein Oxycodone Oxycodone Cyproheptadine NADH NADH Spermine Spermine Phenytoin Phenytoin Lansoprazole Lansoprazole Lansoprazole Lansoprazole Lansoprazole Mephenytoin Mephenytoin Enalapril Enalapril Raloxifene Raloxifene Raloxifene Natalizumab Natalizumab Natalizumab Natalizumab Natalizumab Natalizumab Basiliximab Basiliximab Basiliximab Fluoxetine Fluoxetine Etonogestrel Etonogestrel Etonogestrel Amodiaquine Amodiaquine Amodiaquine Amodiaquine Amodiaquine Atenolol Atenolol Alfuzosin Alfuzosin Alfuzosin Pramipexole Pramipexole Pramipexole Pramipexole Icosapent Icosapent Icosapent Naltrexone Naltrexone Laronidase Laronidase Laronidase Laronidase Laronidase Laronidase Laronidase Laronidase Laronidase Zanamivir Zanamivir Zanamivir Zanamivir Sucralfate Sucralfate Dolasetron Dolasetron Dolasetron Dolasetron Imatinib Imatinib Imatinib Imatinib Lisinopril L-GlutamicAcid L-GlutamicAcid Tamoxifen Tamoxifen Reboxetine Reboxetine Reboxetine Meclizine Interferonbeta-1a Interferonbeta-1a Interferonbeta-1a Gonadorelin Gonadorelin Gonadorelin Verteporfin Verteporfin Verteporfin Aminoglutethimide Lorazepam Lorazepam Prilocaine Prilocaine Ibandronate Masoprocol Risperidone Risperidone Risperidone Haloperidol Haloperidol Haloperidol Haloperidol Cyanocobalamin Oxcarbazepine Oxcarbazepine Foscarnet Foscarnet Foscarnet L-Methionine L-Methionine Azithromycin Azithromycin Azithromycin Mupirocin Mupirocin Pyruvicacid Pyruvicacid L-AsparticAcid L-AsparticAcid Chloroquine Chloroquine Chloroquine Furosemide Furosemide Furosemide CoagulationFactorIX CoagulationFactorIX CoagulationFactorIX CoagulationFactorIX Clavulanate Clavulanate Clavulanate Citalopram Citalopram Citalopram Atropine Fenoldopam Fenoldopam Ritonavir Ritonavir Ritonavir Ritonavir Cyclosporine Cyclosporine Interferonbeta-1b Interferonbeta-1b Monobenzone Monobenzone Monobenzone Monobenzone Ethoxzolamide Ethoxzolamide Ethoxzolamide Ethoxzolamide Verapamil Verapamil Nimodipine Nimodipine Bexarotene Bexarotene Bexarotene Bexarotene L-Valine L-Valine Tramadol Tramadol Tramadol Indomethacin Cevimeline Cevimeline Cevimeline Cevimeline Dofetilide Dofetilide Fondaparinuxsodium Fondaparinuxsodium Fondaparinuxsodium Fondaparinuxsodium Fondaparinuxsodium Fondaparinuxsodium Stavudine Stavudine Stavudine Stavudine Altretamine Altretamine Altretamine Denileukindiftitox Denileukindiftitox Denileukindiftitox L-Lysine L-Lysine L-Lysine Moexipril Moexipril Moexipril Benazepril Benazepril Oxytocin Oxytocin Loratadine Loratadine CoagulationfactorVIIa CoagulationfactorVIIa CoagulationfactorVIIa Chlorzoxazone Indinavir Indinavir Indinavir Bosentan Bosentan Bosentan Bosentan Trimethoprim Trimethoprim Clotrimazole Clotrimazole L-Threonine L-Threonine Acarbose Acarbose Olmesartan Olmesartan Olmesartan Olmesartan Montelukast Montelukast Montelukast Warfarin Warfarin Warfarin Interferongamma-1b Interferongamma-1b Anakinra Anakinra Anakinra Tirofiban Tirofiban Tirofiban Fluphenazine N-Acetyl-D-glucosamine N-Acetyl-D-glucosamine Milrinone Milrinone Chlorambucil Chlorambucil Scopolamine Scopolamine HalobetasolPropionate HalobetasolPropionate HalobetasolPropionate HalobetasolPropionate HalobetasolPropionate Allopurinol Allopurinol Methoxamine Mebendazole Mebendazole Galantamine Galantamine Galantamine Gemcitabine Gemcitabine Gemcitabine Gemcitabine Dexmedetomidine Dexmedetomidine Vidarabine Vidarabine Vidarabine Propranolol Filgrastim Filgrastim Chlorthalidone Chlorthalidone Tenoxicam Dipivefrin Dipivefrin Dipivefrin Dipivefrin Valaciclovir Valaciclovir Valaciclovir Oprelvekin Nitrofurazone Nitrofurazone Nitrofurazone Codeine Deferoxamine Deferoxamine L-Ornithine L-Ornithine Dronabinol Dronabinol Dronabinol Riboflavin Riboflavin Riluzole Riluzole Riluzole Riluzole Marimastat Marimastat Guanidine Guanidine Xanthophyll Xanthophyll Xanthophyll Xanthophyll Icodextrin Icodextrin Rofecoxib Rofecoxib Carbachol Carbachol Voriconazole Voriconazole Voriconazole Voriconazole Voriconazole Mirtazapine Mirtazapine Mirtazapine Lercanidipine Lercanidipine Lercanidipine Omalizumab Omalizumab Omalizumab Omalizumab Omalizumab Brimonidine Brimonidine Alendronate Alendronate Dibucaine Alglucerase Alglucerase Alglucerase Alglucerase Piperacillin Piperacillin Piperacillin CarboprostTromethamine Dicumarol Nabumetone Carbamazepine Carbamazepine Pentamidine Pentamidine Aztreonam Aztreonam Sotalol Sotalol Pentobarbital Torasemide Torasemide Asparaginase Asparaginase Asparaginase Asparaginase Asparaginase Asparaginase Asparaginase Asparaginase Asparaginase Asparaginase Asparaginase Asparaginase Asparaginase Asparaginase Asparaginase Asparaginase Asparaginase Asparaginase Asparaginase Asparaginase Asparaginase Asparaginase Asparaginase Asparaginase Asparaginase Asparaginase Asparaginase Asparaginase Asparaginase Asparaginase Asparaginase Asparaginase Gadodiamide Gadodiamide Gadodiamide Gadodiamide Antithymocyteglobulin Antithymocyteglobulin Antithymocyteglobulin Midazolam Midazolam Hyaluronidase Idoxuridine Idoxuridine Cefalotin Cefalotin Etomidate Etomidate Tenofovir Tenofovir Tenofovir Tenofovir Tenofovir Butalbital Butalbital Butalbital Pentazocine BotulinumToxinTypeB BotulinumToxinTypeB BotulinumToxinTypeB Vincristine Vincristine DornaseAlfa DornaseAlfa Cetuximab Cetuximab Cetuximab Cetuximab Cetuximab Cetuximab Cisplatin Cisplatin Cisplatin Ethosuximide Fluvoxamine Fluvoxamine Vinblastine Vinblastine Chloramphenicol Chloramphenicol Cetirizine Cetirizine Pegaspargase Pegaspargase Pegaspargase Pegaspargase Propylthiouracil Propylthiouracil Hyoscyamine Hyoscyamine Hyoscyamine Trastuzumab Trastuzumab Trastuzumab Trastuzumab L-Phenylalanine L-Phenylalanine Nisoldipine Apomorphine Apomorphine Metformin Metformin Metformin Cetrorelix Hydroflumethiazide Hydroflumethiazide Hydroflumethiazide Hydroflumethiazide Metoprolol Desmopressin Desmopressin Desmopressin Desmopressin Phenelzine Sulpiride Sulpiride Argatroban Argatroban Trihexyphenidyl Trihexyphenidyl Cimetidine Procyclidine Procyclidine Digoxin Digoxin Demeclocycline Goserelin Goserelin Morphine Morphine Oxytetracycline Becaplermin Becaplermin Clofibrate Clofibrate Bendroflumethiazide Sulfanilamide Sulfanilamide Sulfanilamide Sulfanilamide Sulfanilamide Fosinopril Fosinopril Fosinopril Phenindione Phenindione Phenindione Diflorasone Diflorasone Diflorasone Diflorasone Diflorasone Carbenicillin Nitroglycerin Nitroglycerin L-Citrulline L-Citrulline Phosphatidylserine Phosphatidylserine AdefovirDipivoxil AdefovirDipivoxil AdefovirDipivoxil AdefovirDipivoxil Topiramate Topiramate Topiramate Topiramate Tretinoin Tretinoin Sufentanil Sufentanil Sufentanil Sufentanil Daptomycin Daptomycin Daptomycin Daptomycin Alemtuzumab Alemtuzumab Alemtuzumab Flurbiprofen Flurbiprofen Fluorouracil Fluorouracil VitaminA VitaminA VitaminA Nortriptyline Nicardipine Nicardipine Calcidiol Calcidiol Ziprasidone Ziprasidone Palonosetron Palonosetron Palonosetron Palonosetron Palonosetron Palonosetron Hydromorphone Hydromorphone Tetrahydrofolicacid Tetrahydrofolicacid Tetrahydrofolicacid Tetrahydrofolicacid Atracurium Atracurium Palivizumab Palivizumab Palivizumab Moxifloxacin Moxifloxacin Moxifloxacin Moxifloxacin Toremifene Toremifene Toremifene Isoflurophate S-Adenosylmethionine S-Adenosylmethionine S-Adenosylmethionine S-Adenosylmethionine S-Adenosylmethionine Furazolidone Megestrol Megestrol Etoposide Etoposide Urokinase Urokinase Pentostatin Pentostatin Dextromethorphan Sulfasalazine Sulfasalazine Trazodone Trazodone Terfenadine Terfenadine Valsartan Valsartan Valsartan Lepirudin Lepirudin Ticlopidine Ticlopidine Ticlopidine Ticlopidine Aciclovir Aciclovir Aciclovir Alfentanil Doxazosin Nafcillin Adalimumab Adalimumab Adalimumab Adalimumab Adalimumab Adalimumab Pregabalin Pregabalin Pregabalin Pregabalin Pregabalin Mitomycin Mitomycin Framycetin Framycetin Framycetin Teniposide Miglustat Miglustat Miglustat Miglustat Miglustat Miglustat Miglustat Prazosin Pantoprazole Pantoprazole Pantoprazole L-Histidine L-Histidine Pyrazinamide Pyrazinamide Pyrazinamide Olanzapine Olanzapine Olanzapine Vinorelbine Vinorelbine Vinorelbine Vinorelbine L-Arginine L-Arginine Doxycycline Doxycycline Clobazam Clobazam Clobazam Nizatidine Nizatidine Secretin VitaminE VitaminE VitaminE Ranolazine Ranolazine Ranolazine Liothyronine Liothyronine Chlorpromazine Anidulafungin Anidulafungin Anidulafungin Anidulafungin Anidulafungin Anidulafungin Infliximab Infliximab Infliximab Infliximab Infliximab Follitropinbeta Follitropinbeta L-Asparagine L-Asparagine Ethopropazine Ethopropazine Ethopropazine Pralidoxime Imipramine Imipramine Mannitol Mannitol Prednisone Prednisone Prednisone Flutamide Flutamide Linezolid Linezolid Linezolid Linezolid Streptozocin Streptozocin Glutathione Glutathione Pyridoxal Pyridoxal Nystatin Choline Choline Erlotinib Erlotinib Erlotinib Erlotinib Erlotinib Porfimer Cefotaxime Cefotaxime Bentiromide Bentiromide Dyphylline Dyphylline Sulfamethizole Sulfamethizole Sulfamethizole Alprazolam Alprazolam Alprazolam Cidofovir Cidofovir Cidofovir Somatropinrecombinant Somatropinrecombinant Somatropinrecombinant Imiglucerase Imiglucerase Imiglucerase Imiglucerase Imiglucerase Imiglucerase Cycloserine Entacapone Entacapone Entacapone Entacapone Entacapone Eptifibatide Eptifibatide Penciclovir Penciclovir Penciclovir Clodronate Clodronate Clodronate Agalsidasebeta Agalsidasebeta Agalsidasebeta Agalsidasebeta Agalsidasebeta Agalsidasebeta Agalsidasebeta Diatrizoate Clozapine Clozapine Nicotine Nicotine Pefloxacin Methotrexate Methotrexate Alitretinoin Alitretinoin Daunorubicin Daunorubicin Alefacept Alefacept Valdecoxib Valdecoxib Procaine Diethylcarbamazine Diethylcarbamazine Methylphenidate Methylphenidate Secobarbital Dydrogesterone Dydrogesterone Malathion Malathion Desogestrel Desogestrel Sorafenib Sorafenib Sorafenib Sorafenib Sorafenib Sorafenib Sorafenib Dihydroergotamine Dihydroergotamine Mexiletine Mexiletine Nitazoxanide Nitazoxanide Nitazoxanide Nitazoxanide Nitazoxanide Carbinoxamine Carbinoxamine Carbinoxamine Carbinoxamine Carbinoxamine Losartan AminocaproicAcid AminocaproicAcid AminocaproicAcid AmphotericinB AmphotericinB Zoledronate Zoledronate Zoledronate Zoledronate Nitrofurantoin Nitrofurantoin Nitrofurantoin Nitrofurantoin Alpha-LinolenicAcid Alpha-LinolenicAcid AcetohydroxamicAcid AcetohydroxamicAcid Zafirlukast Zafirlukast Tositumomab Tositumomab Rocuronium Rocuronium Rocuronium Methadone Methadone Acamprosate Acamprosate Acamprosate Acamprosate Anistreplase Anistreplase Alteplase Alteplase Mesalazine Mesalazine Mesalazine Muromonab Muromonab Ertapenem Ertapenem Ertapenem Ertapenem Ertapenem Ertapenem Celecoxib Celecoxib Gentamicin Gentamicin Gefitinib Gefitinib Gefitinib Gefitinib Ergocalciferol Ergocalciferol Minoxidil Minoxidil Minaprine Succimer Succimer Pravastatin Pravastatin Benzthiazide Benzthiazide Benzthiazide Benzthiazide Perindopril Perindopril Perindopril Cefixime Cefixime Bisoprolol Bisoprolol Bisoprolol Paroxetine Paroxetine Paroxetine Metolazone Metolazone Metolazone Metolazone Leuprolide Leuprolide Creatine Creatine Piperazine Piperazine Piperazine Piperazine Propoxyphene Latanoprost Latanoprost Latanoprost Latanoprost L-Glutamine L-Glutamine Fluconazole Fluconazole Fluconazole Darbepoetinalfa Darbepoetinalfa Darbepoetinalfa Darbepoetinalfa Temazepam Temazepam Remoxipride Remoxipride Sulindac Sulindac Guanabenz Amoxapine Amoxapine Ergotamine Bevacizumab Bevacizumab Bevacizumab Bevacizumab Bevacizumab Gadoteridol Gadoteridol Gadoteridol Gadoteridol Acitretin Acitretin Acitretin Niacin Niacin Triamcinolone Triamcinolone Hydroxocobalamin Hydroxocobalamin Tranylcypromine Tranylcypromine GadobenateDimeglumine GadobenateDimeglumine GadobenateDimeglumine GadobenateDimeglumine GadobenateDimeglumine Pegvisomant Pegvisomant Pegvisomant Cisapride Cisapride Nevirapine Nevirapine Nevirapine Nevirapine Thioridazine Thioridazine Interferonalfacon-1 Interferonalfacon-1 Interferonalfacon-1 Raltitrexed Raltitrexed SodiumTetradecylSulfate SodiumTetradecylSulfate Enoxacin Vancomycin Vancomycin Vancomycin Buspirone Buspirone Buspirone Tazarotene Tazarotene Tazarotene Gadopentetatedimeglumine Gadopentetatedimeglumine Norgestrel Pegfilgrastim Pegfilgrastim Labetalol Labetalol Travoprost Travoprost Travoprost Travoprost Travoprost Carbidopa Carbidopa Ampicillin Ampicillin Piroxicam Piroxicam Octreotide Octreotide Octreotide Disopyramide Mycophenolatemofetil Mycophenolatemofetil Mycophenolatemofetil Erythromycin Erythromycin Rimantadine Rimantadine Tacrine Tacrine Tacrine Nabilone Nabilone Thiabendazole Thiabendazole Thiabendazole Venlafaxine Venlafaxine Venlafaxine Venlafaxine Alprostadil Alprostadil Trandolapril Trandolapril Trandolapril Spironolactone Spironolactone Acetaminophen Acetaminophen Acetaminophen Pyridoxine Pyridoxine Pyridoxine Methimazole Methimazole Methazolamide Methazolamide Methazolamide Methazolamide Lymecycline Glimepiride Glimepiride Treprostinil Treprostinil Treprostinil Treprostinil Fludrocortisone Fludrocortisone Tamsulosin Tamsulosin Trimipramine Ropinirole Ropinirole Ropinirole Ropinirole Thiamine Simvastatin Simvastatin Gadoversetamide Gadoversetamide Gadoversetamide Gadoversetamide Droperidol Droperidol Ropivacaine Ropivacaine Ropivacaine Ropivacaine Lamotrigine Lamotrigine Lamotrigine Ibritumomab Ibritumomab Ibritumomab Ibritumomab Ibritumomab Sermorelin Sermorelin Glycine Glycine Aprepitant Aprepitant Aprepitant Aprepitant Aprepitant Famciclovir Famciclovir Astemizole Astemizole Astemizole Albendazole Albendazole Albendazole Aminohippurate Aminohippurate Aminohippurate Aminohippurate Nicergoline Nicergoline Clorazepate Clorazepate Etodolac Etodolac Duloxetine Duloxetine Duloxetine Duloxetine Bacitracin Cephalexin Cephalexin Cephalexin Cephalexin Rifabutin Rifabutin Methohexital Methoxsalen Anagrelide Anagrelide Anagrelide Loxapine Loxapine Menotropin Isoflurane Isoflurane Isoflurane Chlorotrianisene Chlorotrianisene Chlorotrianisene Caspofungin Caspofungin Caspofungin Caspofungin Caspofungin Oxyphenonium Oxyphenonium Oxyphenonium Sulfametopyrazine Sulfametopyrazine Sulfametopyrazine Miglitol Miglitol Delavirdine Delavirdine Delavirdine Uracilmustard Uracilmustard Uracilmustard Uracilmustard Uracilmustard Uracilmustard Ketorolac Ketorolac Irinotecan Irinotecan Irinotecan Irinotecan Vindesine Vindesine Clonidine Mecamylamine Mecamylamine Amikacin Amikacin Cabergoline Cabergoline Cabergoline Cabergoline Amlodipine Amlodipine Daclizumab Daclizumab Leucovorin Leucovorin Leucovorin Roxithromycin Candesartan Candesartan Tolcapone Tolcapone Tolcapone Nateglinide Nateglinide Nateglinide Efalizumab Efalizumab Efalizumab Cerivastatin Cerivastatin Floxuridine Ciprofloxacin Ciprofloxacin Ciprofloxacin Cefmenoxime Pimecrolimu Pimecrolimu Isoetharine Isoetharine Gemtuzumabozogamicin Gemtuzumabozogamicin Gemtuzumabozogamicin Gemtuzumabozogamicin Amphetamine Amphetamine Tetrahydrobiopterin Tetrahydrobiopterin Ethambutol Ethambutol Isradipine Clopidogrel Clopidogrel Clopidogrel Clopidogrel Flucloxacillin Adapalene Adapalene Adapalene Palifermin Palifermin Palifermin Thioguanine Thioguanine Thioguanine Epirubicin Epirubicin Epirubicin Trifluridine Trifluridine Phentermine Phentermine Diclofenac Diclofenac Diclofenac Meropenem Meropenem Meropenem Abciximab Abciximab Abciximab L-Proline L-Proline Bivalirudin Bivalirudin Bivalirudin Bivalirudin Medrysone Medrysone Lisuride Lisuride Colistin Colistin Colistin Zolmitriptan Zolmitriptan

Efavirenz Pemetrexed Pemetrexed Sargramostim Enfuvirtide Nelfinavir L-Cysteine Atomoxetine Pyridostigmine Lovastatin PyridoxalPhosphate Bleomycin CalciumAcetate CalciumAcetate Bortezomib Enalapril Raloxifene Icosapent Imatinib Lisinopril Lisinopril Meclizine Foscarnet Mupirocin Fenoldopam Fenoldopam Fenoldopam Fenoldopam Ritonavir Ritonavir Cyclosporine Monobenzone Bexarotene Bexarotene Bexarotene Bexarotene Bexarotene Altretamine Indinavir Bosentan Trimethoprim Tirofiban Gemcitabine Filgrastim Chlorthalidone Marimastat Marimastat Marimastat Xanthophyll Icodextrin Pentamidine Aztreonam Idoxuridine Cisplatin Fluvoxamine Vinblastine Cetirizine Trastuzumab Metformin Valrubicin Valrubicin Desmopressin Argatroban Digoxin Goserelin Becaplermin Fosinopril Fosinopril Etoposide Pentostatin Valsartan Ticlopidine Teniposide Teniposide Pantoprazole Doxycycline Liothyronine Triprolidine Triprolidine Ethopropazine Flutamide Erlotinib Erlotinib Erlotinib Sulfamethizole Somatropinrecombinant Penciclovir Eptifibatide Diatrizoate Pefloxacin Daunorubicin Diethylcarbamazine Dydrogesterone Sorafenib Sorafenib Clemastine Clemastine Rocuronium Celecoxib Gentamicin Gefitinib Pravastatin Bisoprolol Leuprolide Bevacizumab Acitretin Acitretin Pegvisomant Nevirapine Cisapride Raltitrexed Pegfilgrastim Octreotide Tacrine Glimepiride Glimepiride Fludrocortisone Simvastatin Lamotrigine Aminohippurate Chlorotrianisene Triamterene Oxyphenonium Miglitol Miglitol Irinotecan Vindesine Vindesine Cabergoline Amlodipine Amlodipine Roxithromycin Tolcapone Tolcapone Pimecrolimu Isoetharine Clopidogrel Flucloxacillin Thioguanine Epirubicin Abciximab

Baclofen Lindane Lindane Sargramostim Fenfluramine Tetracycline Cladribine Atomoxetine Atomoxetine Atomoxetine Mefloquine Rituximab Pirenzepine Hexachlorophene Pyridostigmine Metyrosine L-Tryptophan VitaminC Mazindol Mazindol Mazindol Mazindol Mazindol Mazindol Mazindol Mazindol Oseltamivir Modafinil Modafinil Modafinil Cyproheptadine Mephenytoin Raloxifene Amsacrine Amsacrine Fluoxetine Pramipexole Pramipexole Pramipexole Naltrexone Reboxetine Reboxetine Reboxetine Reboxetine Reboxetine Tamoxifen Interferonbeta-1a Protriptyline Meclizine Meclizine Haloperidol Risperidone Mupirocin Chloroquine Citalopram Citalopram Citalopram Citalopram Clavulanate Interferonbeta-1b Monobenzone Tramadol L-Valine Denileukindiftitox Tirofiban Galantamine Vidarabine Codeine Dronabinol Mirtazapine Mirtazapine Dibucaine Piperacillin Cefalotin Etomidate Tenofovir Pentazocine Vincristine Fluvoxamine Vinblastine Cetirizine Hyoscyamine Apomorphine Sulpiride Sulpiride Becaplermin Topiramate Alemtuzumab Flurbiprofen Nortriptyline Ziprasidone Dyclonine Dyclonine Dyclonine Dyclonine Dyclonine Reserpine Megestrol Megestrol Etoposide Trazodone Terfenadine Ticlopidine Teniposide Olanzapine Triprolidine Triprolidine Ethopropazine Ethopropazine Prednisone Benztropine Benztropine Benztropine Benztropine Benztropine Benztropine Benztropine Choline Alprazolam Dyphylline Entacapone Clozapine Nicotine Daunorubicin Daunorubicin Daunorubicin Procaine Methylphenidate Methylphenidate Methylphenidate Methylphenidate Methylphenidate AcetohydroxamicAcid Perindopril Paroxetine Paroxetine Piperazine Piperazine Tranylcypromine Cisapride Carbidopa Carbidopa Tacrine Tacrine Thiabendazole Venlafaxine Lamotrigine Sermorelin Sermorelin Sermorelin Nicergoline Duloxetine Isoflurane Vindesine Mecamylamine Cabergoline Tolcapone Tolcapone Gemtuzumabozogamicin Gemtuzumabozogamicin Amphetamine Amphetamine Amphetamine Clopidogrel Thioguanine Thioguanine Phentermine Medrysone

Baclofen Lindane Perflutren L-Cysteine Fenfluramine Fenfluramine Fenfluramine Methysergide Atomoxetine Pirenzepine L-Tryptophan L-Tryptophan VitaminC Mazindol Mazindol Mazindol Mazindol Mazindol Sildenafil Sumatriptan Modafinil Mephenytoin Fluoxetine Fluoxetine Reboxetine Reboxetine Reboxetine Reboxetine Protriptyline Protriptyline Meclizine Risperidone Foscarnet Mupirocin CoagulationFactorIX Citalopram Citalopram Citalopram Citalopram Citalopram Citalopram Citalopram L-Valine Bosentan Mirtazapine Mirtazapine Brimonidine CarboprostTromethamine Fluvoxamine Fluvoxamine Fluvoxamine Fluvoxamine Fluvoxamine Phenelzine Sulfanilamide Nortriptyline Nortriptyline Ziprasidone Reserpine Megestrol Trazodone Olanzapine Imipramine Imipramine Benztropine Benztropine Benztropine Alprazolam Clozapine Nicotine Triflupromazine Methylphenidate Methylphenidate Minaprine Paroxetine Paroxetine Paroxetine Paroxetine Paroxetine Paroxetine Paroxetine Piperazine Piperazine Propoxyphene Propoxyphene Propoxyphene L-Glutamine Amoxapine Amoxapine Hydroxocobalamin Buspirone Carbidopa Venlafaxine Venlafaxine Venlafaxine Trimipramine Famciclovir Aminohippurate Duloxetine Duloxetine Duloxetine Loxapine Loxapine Mecamylamine Amphetamine Phentermine Medrysone Lisuride

Efavirenz Baclofen Perflutren L-Leucine Nelfinavir L-Cystine L-Isoleucine L-Cysteine Amiloride Cladribine Rituximab Pirenzepine Alpha-1-proteinaseinhibitor Pamidronate Inulin Carisoprodol Metyrosine Mazindol Zolpidem Oxiconazole Oxiconazole Oxiconazole Fluorescein Oxycodone Zanamivir L-GlutamicAcid Verteporfin Mupirocin CoagulationFactorIX Ritonavir Cyclosporine Verapamil Tramadol Dofetilide Dofetilide L-Lysine Denileukindiftitox Acarbose N-Acetyl-D-glucosamine Vidarabine Dronabinol Riboflavin Riluzole Guanidine Carbachol Omalizumab Omalizumab Flurazepam Chloramphenicol Trastuzumab Nisoldipine Apomorphine Phenelzine Digoxin Nitroglycerin Alemtuzumab Alemtuzumab Nicardipine Palivizumab Palivizumab Isoflurophate S-Adenosylmethionine Furazolidone Megestrol Doxazosin L-Histidine L-Arginine Triprolidine Triprolidine L-Asparagine Choline Nystatin Nystatin Bentiromide Dyphylline Cycloserine Clodronate Clozapine Dihydroergotamine AminocaproicAcid Alpha-LinolenicAcid Muromonab Minaprine Haloprogin Haloprogin Haloprogin Haloprogin Cefixime Bevacizumab Nevirapine Pyridoxine Capromab Capromab Capromab Ibritumomab Ibritumomab Ibritumomab Glycine Mecamylamine Isoetharine Gemtuzumabozogamicin Gemtuzumabozogamicin Amphetamine Isradipine Thioguanine Abciximab L-Proline Medrysone

Calcitriol Dapsone Baclofen Collagenase FolicAcid Theophylline Nafarelin Nafarelin LipoicAcid LipoicAcid L-Leucine L-Leucine Etanercept BotulinumToxinTypeA Sargramostim Thiopental Nelfinavir Nelfinavir Cinnarizine L-Isoleucine L-Cysteine Enflurane Tenecteplase Fenfluramine Adenine Methysergide Esmolol Methylscopolamine Methylscopolamine Diltiazem Pirenzepine Alpha-1-proteinaseinhibitor Alpha-1-proteinaseinhibitor Hexachlorophene Sulfisoxazole Rasburicase PyridoxalPhosphate PyridoxalPhosphate Carisoprodol Carbimazole ValproicAcid Reteplase Metyrosine L-Tryptophan VitaminC VitaminC Mazindol Vasopressin Zolpidem Butorphanol Cefotiam Aldesleukin Fluorescein NADH Spermine Phenytoin Raloxifene Amsacrine Basiliximab Fluoxetine Naltrexone Zanamivir L-GlutamicAcid Reboxetine Reboxetine Interferonbeta-1a Lorazepam Prilocaine Cyanocobalamin Haloperidol Risperidone Ceruletide Ceruletide Ceruletide Foscarnet Oxcarbazepine L-Methionine Mupirocin L-AsparticAcid Atropine Ritonavir Interferonbeta-1b Monobenzone Verapamil L-Valine Nimodipine Indomethacin L-Lysine L-Lysine Denileukindiftitox Loratadine Indinavir Indinavir Bosentan L-Threonine Montelukast Warfarin Interferongamma-1b N-Acetyl-D-glucosamine Fluphenazine Chlorambucil Chlorambucil Scopolamine Vidarabine Propranolol Nitrofurazone L-Ornithine Deferoxamine Riluzole Guanidine Icodextrin Carbachol Carbachol Voriconazole CarboprostTromethamine Carbamazepine Antithymocyteglobulin Midazolam Idoxuridine Etomidate DornaseAlfa Cisplatin Fluvoxamine Vinblastine Chloramphenicol Cetirizine Hyoscyamine L-Phenylalanine L-Phenylalanine Apomorphine Sulpiride Argatroban Goserelin Becaplermin Sulfanilamide Nitroglycerin Phosphatidylserine Sufentanil Tretinoin Alemtuzumab Daptomycin Flurbiprofen Fluorouracil Ziprasidone Tetrahydrofolicacid Isoflurophate Megestrol Urokinase Terfenadine Aciclovir Doxazosin Mitomycin Miglustat Miglustat Prazosin L-Histidine L-Histidine L-Arginine Triprolidine Triprolidine L-Asparagine L-Asparagine Imipramine Pyridoxal Glutathione Choline Alprazolam Alprazolam Dyphylline Somatropinrecombinant Clodronate Clozapine Nicotine Pefloxacin Alitretinoin Daunorubicin Methylphenidate Methylphenidate Secobarbital Mexiletine Losartan Cyclothiazide Cyclothiazide Alpha-LinolenicAcid Alpha-LinolenicAcid Anistreplase Alteplase Muromonab Ertapenem Gentamicin Ergocalciferol Haloprogin Haloprogin Haloprogin Haloprogin Pravastatin Perindopril Paroxetine Piperazine L-Glutamine Temazepam Carteolol Ergotamine Pegvisomant Nevirapine Metixene Metixene Metixene Metixene Erythromycin Rimantadine Pyridoxine Fludrocortisone Ropivacaine Glycine Glycine Astemizole Nicergoline Nicergoline Bacitracin Rifabutin Isoflurane Chlorotrianisene Vindesine Clonidine Daclizumab Roxithromycin Cerivastatin Isoetharine Palifermin Thioguanine Trifluridine L-Proline L-Proline Bivalirudin Medrysone

Calcitriol Calcitriol Dapsone L-Leucine Etanercept Carmustine L-Cysteine Tenecteplase Cladribine Troglitazone Troglitazone Troglitazone Rosiglitazone Methylscopolamine NitricOxide Lovastatin Lovastatin Reteplase Bleomycin Bortezomib Bortezomib Benzquinamide Benzquinamide Benzquinamide Oxaliplatin AntihemophilicFactor Spermine Imatinib Tamoxifen Interferonbeta-1a CoagulationFactorIX Interferonbeta-1b L-Threonine L-Threonine Gemcitabine Vidarabine Nitrofurazone L-Ornithine Deferoxamine Xanthophyll Dicumarol Antithymocyteglobulin Idoxuridine Vincristine Cetuximab Cisplatin Vinblastine Becaplermin Becaplermin Tretinoin Tretinoin Flurbiprofen Fluorouracil Megestrol Etoposide Etoposide Terfenadine Mitomycin Teniposide Vinorelbine Doxycycline Imipramine Streptozocin Glutathione Erlotinib Bentiromide Porfimer Alitretinoin Alitretinoin Alitretinoin Daunorubicin Sorafenib Zoledronate Alpha-LinolenicAcid Anistreplase Alteplase Celecoxib Celecoxib Gefitinib Minaprine Sulindac Sulindac Sulindac Tazarotene Tazarotene Simvastatin Sermorelin Sermorelin Astemizole Etodolac Rifabutin Methoxsalen Oxyphenonium Irinotecan Amlodipine Cerivastatin Cerivastatin Palifermin Medrysone

Calcitriol Lactulose Collagenase Lidocaine Cinnarizine Zileuton Amiloride Fenfluramine Troglitazone L-Carnitine L-Carnitine Griseofulvin Ipratropiumbromide Lovastatin Methyclothiazide Methyclothiazide AminosalicylicAcid Vasopressin Sildenafil Sildenafil Oxaliplatin AntihemophilicFactor Nitroprusside Fluorescein Oxycodone Spermine Enalapril Amsacrine Fluoxetine Pramipexole Imatinib Foscarnet Pyruvicacid Pyruvicacid Ethoxzolamide Ethoxzolamide Ethoxzolamide Altretamine Denileukindiftitox Bosentan Bosentan L-Ornithine Icodextrin Torasemide Torasemide Gadodiamide Etomidate Vinblastine Cetirizine L-Phenylalanine Nisoldipine Clofibrate Flurbiprofen Nortriptyline Mitomycin L-Arginine VitaminE Streptozocin Bentiromide Cidofovir Oxandrolone Mexiletine Losartan Cyclothiazide Celecoxib Succimer Succimer Pravastatin L-Glutamine Carbidopa Octreotide Disopyramide Pentagastrin Pentagastrin Pentagastrin Alprostadil Pyridoxine Fludrocortisone Simvastatin Aminohippurate Aminohippurate Chlorotrianisene Oxyphenonium Vindesine Roxithromycin Nateglinide Nateglinide Nateglinide Ethambutol Isradipine Isradipine Thioguanine Diclofenac

Efavirenz Efavirenz Efavirenz Efavirenz Efavirenz Pemetrexed Pemetrexed Pemetrexed Pemetrexed Calcitriol Calcitriol Calcitriol Dapsone Dapsone Dapsone Lactulose Lactulose Lactulose Lactulose Baclofen Baclofen Collagenase Collagenase FolicAcid FolicAcid FolicAcid FolicAcid Theophylline Theophylline Clofarabine Clofarabine Clofarabine Sulfadiazine Sulfadiazine Sulfadiazine Lidocaine Lidocaine Lidocaine Lidocaine Lindane Lindane Dapiprazole Dapiprazole Dapiprazole Dapiprazole Oxacillin Oxacillin Succinylcholine Succinylcholine Entecavir Entecavir Entecavir Perflutren Perflutren Perflutren Perflutren Perflutren L-Leucine L-Leucine Etanercept Etanercept Etanercept BotulinumToxinTypeA BotulinumToxinTypeA BotulinumToxinTypeA BotulinumToxinTypeA BotulinumToxinTypeA BotulinumToxinTypeA Sargramostim Sargramostim Sargramostim Enfuvirtide Enfuvirtide Enfuvirtide Levonorgestrel Levonorgestrel Levonorgestrel Levonorgestrel Epoetinalfa Epoetinalfa Epoetinalfa Epoetinalfa Thiopental Thiopental Thiopental Nelfinavir Nelfinavir Nelfinavir Nelfinavir Progesterone Progesterone L-Cystine Cinnarizine Carmustine Carmustine Tolazoline L-Isoleucine L-Cysteine L-Cysteine Enflurane Enflurane Zileuton Zileuton Zileuton Zileuton Amiloride Amiloride Tenecteplase Tenecteplase Imiquimod Fenfluramine Fenfluramine Tetracycline Tetracycline Tetracycline Ceftazidime Ceftazidime Adenine Metaraminol Metaraminol Ibutilide Ibutilide Ibutilide Ibutilide Ibutilide Ibutilide Cladribine Troglitazone Troglitazone Troglitazone Phentolamine Tigecycline Tigecycline Betaxolol Betaxolol Betaxolol Atomoxetine Atomoxetine Atomoxetine Atomoxetine Atomoxetine Mefloquine Mefloquine Esmolol Esmolol Esmolol Esmolol Esmolol Estrone Estrone Epinastine Epinastine Epinastine Epinastine Bupivacaine Bupivacaine Bupivacaine Bupivacaine Bupivacaine Rosiglitazone Rosiglitazone Rosiglitazone Rosiglitazone L-Carnitine L-Carnitine L-Carnitine Methylscopolamine Naftifine Naftifine Naftifine Rituximab Rituximab Fluorometholone Fluorometholone Fluorometholone Fluorometholone Fluorometholone NitricOxide NitricOxide Diltiazem Diltiazem Lenalidomide Dexrazoxane Pirenzepine Pirenzepine Pirenzepine Testosterone Testosterone Testosterone Alpha-1-proteinaseinhibitor Alpha-1-proteinaseinhibitor Alpha-1-proteinaseinhibitor Flunisolide Flunisolide Flunisolide Flunisolide Hexachlorophene Hexachlorophene Hexachlorophene Hexachlorophene Sulfisoxazole Sulfisoxazole Sulfisoxazole Menadione Pyridostigmine Pyridostigmine Pyridostigmine Hydroxyzine Hydroxyzine Hydroxyzine Pamidronate Pamidronate Pamidronate Pamidronate Griseofulvin Betamethasone Betamethasone Betamethasone Inulin Inulin Inulin Mitotane Mitotane Ipratropiumbromide Ipratropiumbromide Ipratropiumbromide Ipratropiumbromide Ipratropiumbromide Succinicacid Succinicacid Nedocromil Nedocromil Ramipril Ramipril Ramipril Lovastatin Lovastatin Eplerenone Eplerenone Eplerenone Trovafloxacin Trovafloxacin Trovafloxacin Rasburicase Rasburicase Rasburicase PyridoxalPhosphate PyridoxalPhosphate Midodrine Midodrine Midodrine Carisoprodol Carisoprodol Carbimazole Carbimazole Propiomazine Propiomazine Propiomazine Propiomazine ValproicAcid ValproicAcid Reteplase Reteplase Metyrosine Metyrosine Methylergonovine Methylergonovine L-Tryptophan VitaminC VitaminC VitaminC Mazindol AminosalicylicAcid AminosalicylicAcid AminosalicylicAcid Amitriptyline Amitriptyline Beclomethasone Beclomethasone Beclomethasone Beclomethasone Meperidine Meperidine Meperidine Bleomycin Bleomycin Tizanidine Tizanidine Tizanidine Tizanidine Vasopressin Vasopressin Zolpidem Zolpidem Mometasone Mometasone Mometasone Mometasone Sildenafil Sildenafil Sildenafil Sildenafil Butorphanol Butorphanol Butorphanol Butorphanol Butorphanol Butorphanol InterferonAlfa-2a,Recombinant InterferonAlfa-2a,Recombinant InterferonAlfa-2a,Recombinant CalciumAcetate CalciumAcetate CalciumAcetate Esomeprazole Esomeprazole Esomeprazole Cefotiam Cefotiam Cefotiam Sumatriptan Sumatriptan Sumatriptan Bortezomib Bortezomib Timolol Timolol Timolol Timolol Fenoprofen Lamivudine Lamivudine Lamivudine Lamivudine Oxaliplatin Oxaliplatin Oxaliplatin Oxaliplatin Oxaliplatin Acetohexamide Acetohexamide Acetohexamide Eletriptan Eletriptan Eletriptan Eletriptan Tobramycin Tobramycin Tobramycin Aldesleukin Aldesleukin AntihemophilicFactor AntihemophilicFactor AntihemophilicFactor AntihemophilicFactor Oseltamivir Oseltamivir Oseltamivir Modafinil Modafinil Modafinil Modafinil Modafinil Modafinil Nitroprusside Nitroprusside Nitroprusside Fluorescein Fluorescein Fluorescein Fluorescein Oxycodone Oxycodone Oxycodone Oxycodone Oxycodone Cyproheptadine Cyproheptadine NADH Spermine Spermine Phenytoin Phenytoin Lansoprazole Lansoprazole Lansoprazole Mephenytoin Mephenytoin Mephenytoin Enalapril Enalapril Enalapril Raloxifene Raloxifene Raloxifene Raloxifene Natalizumab Natalizumab Natalizumab Amsacrine Basiliximab Basiliximab Basiliximab Basiliximab Basiliximab Fluoxetine Fluoxetine Fluoxetine Etonogestrel Etonogestrel Etonogestrel Etonogestrel Amodiaquine Amodiaquine Atenolol Atenolol Atenolol Alfuzosin Alfuzosin Alfuzosin Alfuzosin Alfuzosin Alfuzosin Pramipexole Pramipexole Pramipexole Pramipexole Pramipexole Icosapent Icosapent Icosapent Naltrexone Naltrexone Naltrexone Sucralfate Sucralfate Sucralfate Zanamivir Zanamivir Dolasetron Dolasetron Dolasetron Imatinib Imatinib Imatinib Lisinopril Lisinopril Lisinopril Lisinopril L-GlutamicAcid Reboxetine Reboxetine Reboxetine Reboxetine Tamoxifen Tamoxifen Tamoxifen Interferonbeta-1a Interferonbeta-1a Meclizine Meclizine Aminoglutethimide Verteporfin Verteporfin Verteporfin Verteporfin Verteporfin Gonadorelin Gonadorelin Lorazepam Lorazepam Lorazepam Ibandronate Ibandronate Ibandronate Ibandronate Prilocaine Prilocaine Prilocaine Masoprocol Masoprocol Cyanocobalamin Cyanocobalamin Cyanocobalamin Haloperidol Haloperidol Risperidone Risperidone Risperidone Risperidone Risperidone Risperidone Streptokinase Streptokinase Ceruletide Ceruletide Foscarnet Foscarnet Foscarnet Oxcarbazepine Oxcarbazepine Oxcarbazepine Oxcarbazepine Azithromycin Azithromycin Azithromycin L-Methionine L-Methionine Pyruvicacid Pyruvicacid Mupirocin Mupirocin Mupirocin L-AsparticAcid L-AsparticAcid L-AsparticAcid L-AsparticAcid L-AsparticAcid L-AsparticAcid L-AsparticAcid L-AsparticAcid Chloroquine Chloroquine CoagulationFactorIX CoagulationFactorIX CoagulationFactorIX Furosemide Furosemide Furosemide Citalopram Citalopram Citalopram Citalopram Clavulanate Clavulanate Clavulanate Atropine Atropine Fenoldopam Fenoldopam Fenoldopam Ritonavir Ritonavir Ritonavir Ritonavir Ritonavir Cyclosporine Cyclosporine Cyclosporine Interferonbeta-1b Interferonbeta-1b Monobenzone Monobenzone Verapamil Verapamil Tramadol Tramadol Tramadol Tramadol Tramadol L-Valine L-Valine Nimodipine Nimodipine Dofetilide Dofetilide Dofetilide Indomethacin Indomethacin Choriogonadotropinalfa Choriogonadotropinalfa Choriogonadotropinalfa Choriogonadotropinalfa Stavudine Stavudine Stavudine Stavudine Altretamine Altretamine DigoxinImmuneFab DigoxinImmuneFab DigoxinImmuneFab DigoxinImmuneFab DigoxinImmuneFab DigoxinImmuneFab DigoxinImmuneFab DigoxinImmuneFab DigoxinImmuneFab DigoxinImmuneFab DigoxinImmuneFab DigoxinImmuneFab L-Lysine L-Lysine Denileukindiftitox Denileukindiftitox Denileukindiftitox Benazepril Benazepril Benazepril Benazepril Benazepril Oxytocin Oxytocin CoagulationfactorVIIa CoagulationfactorVIIa CoagulationfactorVIIa CoagulationfactorVIIa Loratadine Loratadine Loratadine Indinavir Indinavir Indinavir Indinavir Chlorzoxazone Chlorzoxazone Chlorzoxazone Chlorzoxazone Bosentan Bosentan Bosentan Bosentan Trimethoprim Trimethoprim Clotrimazole Clotrimazole L-Threonine Olmesartan Olmesartan Olmesartan Acarbose Acarbose Acarbose Acarbose Montelukast Montelukast Montelukast Warfarin Warfarin Anakinra Anakinra Anakinra Interferongamma-1b Interferongamma-1b Tirofiban Tirofiban Tirofiban N-Acetyl-D-glucosamine N-Acetyl-D-glucosamine N-Acetyl-D-glucosamine Fluphenazine Fluphenazine Milrinone Milrinone Chlorambucil Scopolamine Scopolamine Scopolamine Allopurinol Allopurinol Allopurinol Methoxamine Methoxamine Mebendazole Gemcitabine Gemcitabine Gemcitabine Gemcitabine Galantamine Galantamine Galantamine Galantamine Dexmedetomidine Dexmedetomidine Dexmedetomidine Dexmedetomidine Dexmedetomidine Dexmedetomidine Dexmedetomidine Vidarabine Filgrastim Filgrastim Filgrastim Propranolol Chlorthalidone Chlorthalidone Tenoxicam Tenoxicam Tenoxicam Dipivefrin Dipivefrin Dipivefrin Oprelvekin Oprelvekin Oprelvekin Valaciclovir Valaciclovir Valaciclovir Codeine Codeine Nitrofurazone Nitrofurazone L-Ornithine L-Ornithine Deferoxamine Deferoxamine Dronabinol Dronabinol Riboflavin Riboflavin Riluzole Riluzole Marimastat Marimastat Xanthophyll Xanthophyll Xanthophyll Guanidine FluticasonePropionate FluticasonePropionate FluticasonePropionate FluticasonePropionate FluticasonePropionate FluticasonePropionate FluticasonePropionate Icodextrin Icodextrin Icodextrin Carbachol Carbachol Rofecoxib Rofecoxib Rofecoxib Rofecoxib Voriconazole Voriconazole Voriconazole Mirtazapine Mirtazapine Mirtazapine Mirtazapine Omalizumab Omalizumab Lercanidipine Lercanidipine Lercanidipine Lercanidipine Brimonidine Brimonidine Brimonidine Brimonidine Brimonidine Alendronate Alendronate Alendronate Alendronate Alendronate Alendronate Dibucaine Dibucaine Alglucerase Alglucerase Alglucerase Piperacillin Piperacillin CarboprostTromethamine CarboprostTromethamine CarboprostTromethamine CarboprostTromethamine Dicumarol Nabumetone Nabumetone Nabumetone Carbamazepine Carbamazepine Carbamazepine Pentamidine Pentamidine Aztreonam Aztreonam Sotalol Sotalol Sotalol Pentobarbital Pentobarbital Torasemide Torasemide Gadodiamide Gadodiamide Gadodiamide Gadodiamide Gadodiamide Antithymocyteglobulin Antithymocyteglobulin Antithymocyteglobulin Midazolam Midazolam Midazolam Midazolam Midazolam Hyaluronidase Hyaluronidase Cefmetazole Idoxuridine Idoxuridine Cefalotin Cefalotin Etomidate Etomidate Etomidate Etomidate Tenofovir Tenofovir Tenofovir Butalbital Butalbital Butalbital Butalbital Pentazocine Pentazocine BotulinumToxinTypeB BotulinumToxinTypeB BotulinumToxinTypeB BotulinumToxinTypeB Vincristine Vincristine DornaseAlfa Cetuximab Cetuximab Cetuximab Cisplatin Cisplatin Cisplatin Flurazepam Fluvoxamine Fluvoxamine Fluvoxamine Fluvoxamine Vinblastine Vinblastine Chloramphenicol Chloramphenicol Cetirizine Cetirizine Cetirizine Cetirizine Propylthiouracil Propylthiouracil Hyoscyamine Hyoscyamine Trastuzumab Trastuzumab Trastuzumab L-Phenylalanine Apomorphine Apomorphine Metformin Metformin Metformin Metformin Metformin Cetrorelix Cetrorelix Cetrorelix Cetrorelix Valrubicin Valrubicin Valrubicin Valrubicin Valrubicin Valrubicin Metoprolol Metoprolol Metoprolol Desmopressin Desmopressin Desmopressin Phenelzine Sulpiride Sulpiride Argatroban Argatroban Argatroban Trihexyphenidyl Trihexyphenidyl Eszopiclone Eszopiclone Eszopiclone Eszopiclone Cimetidine Cimetidine Procyclidine Procyclidine Procyclidine Digoxin Digoxin Goserelin Goserelin Goserelin Goserelin Morphine Morphine Morphine Becaplermin Oxytetracycline Clofibrate Clofibrate Bendroflumethiazide Bendroflumethiazide Bendroflumethiazide Sulfanilamide Sulfanilamide Phenindione Phenindione Phenindione Fosinopril Fosinopril Fosinopril Fosinopril Fosinopril Cefdinir Cefdinir Cefdinir Cefdinir Carbenicillin L-Citrulline L-Citrulline Nitroglycerin Nitroglycerin Nitroglycerin Phosphatidylserine AdefovirDipivoxil AdefovirDipivoxil AdefovirDipivoxil Topiramate Topiramate Topiramate Topiramate Sufentanil Sufentanil Sufentanil Sufentanil Sufentanil Sufentanil Tretinoin Tretinoin GallamineTriethiodide Alemtuzumab Alemtuzumab Daptomycin Daptomycin Flurbiprofen Flurbiprofen VitaminA VitaminA Fluorouracil Fluorouracil Fluorouracil Nortriptyline Nortriptyline Nortriptyline Ziprasidone Ziprasidone Ziprasidone Ziprasidone Calcidiol Calcidiol Calcidiol Calcidiol Calcidiol Nicardipine Nicardipine Dyclonine Dyclonine Dyclonine Dyclonine Dyclonine Dyclonine Palonosetron Palonosetron Hydromorphone Hydromorphone Hydromorphone Hydromorphone Tetrahydrofolicacid Tetrahydrofolicacid Atracurium Atracurium Atracurium Atracurium Atracurium Palivizumab Palivizumab Palivizumab Olopatadine Olopatadine Olopatadine Olopatadine Olopatadine Moxifloxacin Moxifloxacin Moxifloxacin Moxifloxacin Toremifene Toremifene Toremifene Toremifene Reserpine Isoflurophate Isoflurophate S-Adenosylmethionine S-Adenosylmethionine S-Adenosylmethionine ThyrotropinAlfa ThyrotropinAlfa Furazolidone Furazolidone Megestrol Megestrol Megestrol Megestrol Urokinase Urokinase Etoposide Etoposide Dextromethorphan Dextromethorphan Dextromethorphan Dextromethorphan Pentostatin Pentostatin Sulfasalazine Sulfasalazine Trazodone Trazodone Trazodone Terfenadine Terfenadine Terfenadine Felypressin Felypressin Valsartan Valsartan Valsartan Valsartan Valsartan Valsartan Ticlopidine Ticlopidine Ticlopidine Lepirudin Lepirudin Lepirudin Aciclovir Aciclovir Doxazosin Doxazosin Doxazosin Alfentanil Alfentanil Alfentanil Alfentanil Alfentanil Adalimumab Adalimumab Adalimumab Adalimumab Pregabalin Pregabalin Pregabalin Pregabalin Mitomycin Mitomycin Mitomycin Framycetin Teniposide Miglustat Miglustat Miglustat Miglustat Miglustat Prazosin Prazosin Pantoprazole Pantoprazole Pantoprazole Pantoprazole Pyrazinamide Pyrazinamide Pyrazinamide L-Histidine Olanzapine Olanzapine Olanzapine Olanzapine Olanzapine Vinorelbine Vinorelbine Vinorelbine Vinorelbine L-Arginine L-Arginine Doxycycline Doxycycline Peginterferonalfa-2a Peginterferonalfa-2a Peginterferonalfa-2a Peginterferonalfa-2a Peginterferonalfa-2a Peginterferonalfa-2a Peginterferonalfa-2a Peginterferonalfa-2a Clobazam Clobazam Clobazam VitaminE VitaminE VitaminE Secretin Nizatidine Nizatidine Nizatidine Chlorpromazine Liothyronine Liothyronine Liothyronine Tolmetin Infliximab Infliximab Infliximab Infliximab L-Asparagine Follitropinbeta Follitropinbeta Follitropinbeta gamma-Homolinolenicacid gamma-Homolinolenicacid gamma-Homolinolenicacid gamma-Homolinolenicacid Ethopropazine Ethopropazine Imipramine Imipramine Imipramine Pralidoxime Prednisone Prednisone Prednisone Mannitol Mannitol Mannitol Thiethylperazine Thiethylperazine Propantheline Propantheline Flutamide Flutamide Flutamide Flutamide Linezolid Linezolid Linezolid Streptozocin Streptozocin Streptozocin Streptozocin Pyridoxal Pyridoxal Pyridoxal Glutathione Glutathione Glutathione Glutathione Benztropine Benztropine Choline Choline Nystatin Erlotinib Erlotinib Erlotinib Erlotinib Bentiromide Bentiromide Bentiromide Bentiromide Bentiromide Bentiromide Cefotaxime Cefotaxime Porfimer Porfimer Alprazolam Alprazolam Alprazolam Sulfamethizole Sulfamethizole Sulfamethizole Dyphylline Dyphylline Dyphylline Dyphylline Tripelennamine Cidofovir Cidofovir Somatropinrecombinant Somatropinrecombinant Somatropinrecombinant Somatropinrecombinant Somatropinrecombinant Imiglucerase Imiglucerase Imiglucerase Entacapone Entacapone Entacapone Entacapone Cycloserine Cycloserine Penciclovir Eptifibatide Eptifibatide Eptifibatide Diatrizoate Diatrizoate Diatrizoate Agalsidasebeta Agalsidasebeta Agalsidasebeta Agalsidasebeta Clodronate Clodronate Clodronate Clozapine Clozapine Clozapine Nicotine Nicotine Nicotine Pefloxacin Pefloxacin Trimethobenzamide Trimethobenzamide Trimethobenzamide Trimethobenzamide Methotrexate Methotrexate Oxandrolone Oxandrolone Oxandrolone Oxandrolone Oxandrolone Daunorubicin Daunorubicin Trospium Trospium Trospium Valdecoxib Valdecoxib Valdecoxib Valdecoxib Diethylcarbamazine Diethylcarbamazine Procaine Methylphenidate Methylphenidate Methylphenidate Methylphenidate Secobarbital Nilutamide Nilutamide Dydrogesterone Dydrogesterone Dydrogesterone Malathion Malathion Malathion Sorafenib Sorafenib Sorafenib Sorafenib Desogestrel Desogestrel Desogestrel Dihydroergotamine Mexiletine Mexiletine Clemastine Clemastine Nitazoxanide Nitazoxanide Nitazoxanide AminocaproicAcid AminocaproicAcid AminocaproicAcid Losartan Losartan Losartan Losartan AmphotericinB AmphotericinB Zoledronate Zoledronate Zoledronate Zoledronate Cyclothiazide Cyclothiazide Nitrofurantoin Alpha-LinolenicAcid Alpha-LinolenicAcid Zafirlukast Zafirlukast Zafirlukast Zafirlukast AcetohydroxamicAcid AcetohydroxamicAcid AcetohydroxamicAcid Tositumomab Tositumomab Tositumomab Tositumomab Methadone Methadone Methadone Rocuronium Rocuronium Rocuronium Rocuronium Rocuronium Rocuronium Rocuronium Rocuronium Acamprosate Acamprosate Anistreplase Anistreplase Alteplase Alteplase Mesalazine Mesalazine Mesalazine Muromonab Celecoxib Celecoxib Celecoxib Celecoxib Ertapenem Ertapenem Ertapenem Ertapenem Gentamicin Gentamicin Gefitinib Gefitinib Gefitinib Gefitinib Ergocalciferol Ergocalciferol Ergocalciferol Minoxidil Minoxidil Minaprine Minaprine Succimer Succimer Succimer Succimer Pravastatin Pravastatin Pravastatin Pravastatin Cefixime Cefixime Perindopril Perindopril Perindopril Perindopril Perindopril Bisoprolol Bisoprolol Bisoprolol Metolazone Metolazone Metolazone Paroxetine Paroxetine Paroxetine Paroxetine Leuprolide Leuprolide Leuprolide Leuprolide Leuprolide Creatine Creatine Creatine Creatine Piperazine Piperazine Propoxyphene Propoxyphene Latanoprost Latanoprost Latanoprost Latanoprost Latanoprost Latanoprost Latanoprost Latanoprost Chlorpropamide L-Glutamine L-Glutamine Fluconazole Fluconazole Darbepoetinalfa Darbepoetinalfa Darbepoetinalfa Darbepoetinalfa Temazepam Temazepam Temazepam Sulindac Sulindac Sulindac Guanabenz Carteolol Carteolol Carteolol Carteolol Amoxapine InsulinLispro InsulinLispro InsulinLispro InsulinLispro InsulinLispro InsulinLispro InsulinLispro InsulinLispro Bevacizumab Bevacizumab Bevacizumab Bevacizumab Bevacizumab Ergotamine Gadoteridol Gadoteridol Gadoteridol Gadoteridol Gadoteridol Acitretin Acitretin Triamcinolone Triamcinolone Triamcinolone Triamcinolone Niacin Niacin Niacin Hydroxocobalamin Hydroxocobalamin Pegvisomant Pegvisomant Pegvisomant Pegvisomant Pegvisomant GadobenateDimeglumine GadobenateDimeglumine Tranylcypromine Tranylcypromine Nevirapine Nevirapine Nevirapine Nevirapine Nevirapine Cisapride Cisapride Cisapride Cisapride Thioridazine Serumalbumin Serumalbumin Serumalbumin Serumalbumin Serumalbumin Raltitrexed Raltitrexed Raltitrexed Raltitrexed Enoxacin Enoxacin SodiumTetradecylSulfate SodiumTetradecylSulfate SodiumTetradecylSulfate Vancomycin Vancomycin Buspirone Buspirone Gadopentetatedimeglumine Gadopentetatedimeglumine Gadopentetatedimeglumine Tazarotene Tazarotene Tazarotene Norgestrel Norgestrel Pegfilgrastim Pegfilgrastim Pegfilgrastim Travoprost Travoprost Travoprost Travoprost Travoprost Travoprost Labetalol Labetalol Carbidopa Carbidopa Carbidopa Ampicillin Ampicillin Octreotide Octreotide Octreotide Piroxicam Piroxicam Disopyramide Disopyramide Mycophenolatemofetil Mycophenolatemofetil Mycophenolatemofetil Mycophenolatemofetil Erythromycin Erythromycin Erythromycin Rimantadine Rimantadine Tacrine Tacrine Tacrine Nabilone Nabilone Nabilone Thiabendazole Venlafaxine Venlafaxine Venlafaxine Venlafaxine Pentagastrin Alprostadil Alprostadil Trandolapril Trandolapril Trandolapril Trandolapril Spironolactone Spironolactone Acetaminophen Acetaminophen Acetaminophen Pyridoxine Pyridoxine Pyridoxine Methimazole Methimazole Methazolamide Lymecycline Glimepiride Glimepiride Glimepiride Glimepiride Glimepiride Glimepiride Prochlorperazine Prochlorperazine Treprostinil Treprostinil Treprostinil Treprostinil Treprostinil Treprostinil Capromab Capromab Capromab Fludrocortisone Fludrocortisone Fludrocortisone Tamsulosin Tamsulosin Tamsulosin Tamsulosin Trimipramine Trimipramine Trimipramine Ropinirole Ropinirole Ropinirole Ropinirole Ropinirole Thiamine Simvastatin Simvastatin Simvastatin Simvastatin Gadoversetamide Gadoversetamide Gadoversetamide Gadoversetamide Droperidol Droperidol Ropivacaine Ropivacaine Ropivacaine Ropivacaine Ropivacaine Ropivacaine Ropivacaine Lamotrigine Lamotrigine Lamotrigine Lamotrigine Ibritumomab Ibritumomab Ibritumomab Dicyclomine Dicyclomine Glycine Glycine Aprepitant Aprepitant Aprepitant Famciclovir Famciclovir Famciclovir Astemizole Astemizole Astemizole Albendazole Albendazole Aminohippurate Aminohippurate Aminohippurate Nicergoline Nicergoline Clorazepate Clorazepate Clorazepate Etodolac Etodolac Etodolac Etodolac Duloxetine Duloxetine Duloxetine Duloxetine Bacitracin Doxapram Doxapram Doxapram Doxapram Cephalexin Cephalexin Cephalexin Rifabutin Rifabutin Rifabutin Methohexital Methohexital Methohexital Methoxsalen Methoxsalen Anagrelide Anagrelide Anagrelide Loxapine Loxapine Menotropin Menotropin Isoflurane Isoflurane Isoflurane Isoflurane Isoflurane Chlorotrianisene Chlorotrianisene Chlorotrianisene Chlorotrianisene Triamterene Caspofungin Caspofungin Oxyphenonium Oxyphenonium Sulfametopyrazine Sulfametopyrazine Sulfametopyrazine Miglitol Miglitol Miglitol InsulinGlargine InsulinGlargine InsulinGlargine InsulinGlargine Delavirdine Delavirdine Ketorolac Ketorolac Ketorolac Ketorolac Ketorolac Irinotecan Irinotecan Irinotecan Irinotecan Vindesine Vindesine Clonidine Clonidine Clonidine Mecamylamine Amikacin Amikacin Cabergoline Cabergoline Cabergoline Amlodipine Amlodipine Amlodipine Amlodipine Amlodipine Daclizumab Daclizumab Daclizumab Leucovorin Leucovorin Leucovorin Leucovorin Roxithromycin Roxithromycin Candesartan Candesartan Candesartan Candesartan Tolcapone Tolcapone Tolcapone Nateglinide Nateglinide Nateglinide Cerivastatin Cerivastatin Cerivastatin Trimethadione Floxuridine Ciprofloxacin Ciprofloxacin Pimecrolimu Pimecrolimu Pimecrolimu Pimecrolimu Isoetharine Isoetharine Isoetharine Gemtuzumabozogamicin Gemtuzumabozogamicin Gemtuzumabozogamicin Amphetamine Amphetamine Tetrahydrobiopterin Tetrahydrobiopterin Tetrahydrobiopterin Ethambutol Ethambutol Ethambutol Isradipine Isradipine Clopidogrel Clopidogrel Clopidogrel Flucloxacillin Flucloxacillin Adapalene Adapalene Palifermin Palifermin Palifermin Thioguanine Thioguanine Thioguanine Thioguanine Epirubicin Epirubicin Epirubicin Epirubicin Trifluridine Trifluridine Phentermine Phentermine Diclofenac Diclofenac Diclofenac Diclofenac Meropenem Meropenem Meropenem Abciximab Abciximab Abciximab L-Proline Urofollitropin Urofollitropin Bivalirudin Bivalirudin Medrysone Medrysone Medrysone Medrysone Lisuride Lisuride Colistin Colistin Nitisinone Nitisinone Nitisinone Zolmitriptan Zolmitriptan

FolicAcid Nelfinavir Zileuton Ibutilide Ibutilide Ibutilide Troglitazone Atomoxetine Rosiglitazone L-Carnitine L-Carnitine L-Carnitine L-Carnitine L-Carnitine Darifenacin Darifenacin Lenalidomide Hexachlorophene Pamidronate Ipratropiumbromide Eplerenone Eplerenone Eplerenone PyridoxalPhosphate VitaminC Amitriptyline Meperidine Bleomycin Sildenafil Oxaliplatin AntihemophilicFactor Oseltamivir Oxycodone Oxycodone Lansoprazole Enalapril Basiliximab Icosapent Verapamil Dofetilide Dofetilide Dofetilide Altretamine Bosentan Bosentan Olmesartan Montelukast Deferoxamine Guanidine Grepafloxacin Grepafloxacin Dibucaine Sotalol Sotalol Antithymocyteglobulin Cetirizine Sulpiride Digoxin Clofibrate L-Citrulline Phosphatidylserine Alemtuzumab VitaminA Ziprasidone Hydromorphone Pentostatin Terfenadine Valsartan Mitomycin L-Arginine Ranolazine Ranolazine gamma-Homolinolenicacid gamma-Homolinolenicacid Moricizine Moricizine Pyridoxal Choline Bentiromide Cidofovir Eptifibatide Alitretinoin Mexiletine AminocaproicAcid AminocaproicAcid Losartan AcetohydroxamicAcid Rocuronium Minaprine Pravastatin Bisoprolol Hydroxocobalamin SodiumTetradecylSulfate Disopyramide Trandolapril Trandolapril Spironolactone Acetaminophen Simvastatin Astemizole Aminohippurate Oxyphenonium Ketorolac Amlodipine Isradipine Clopidogrel Palifermin Thioguanine

Lactulose Theophylline Clofarabine Clofarabine Clofarabine Clofarabine Entecavir L-Leucine Enfuvirtide L-Cystine L-Isoleucine L-Cysteine Amiloride Tenecteplase Adenine Adenine Cladribine Cladribine Levallorphan L-Carnitine Succinicacid Lovastatin PyridoxalPhosphate Reteplase Metyrosine L-Tryptophan Cefotiam Lamivudine NADH Spermine Amsacrine Amsacrine L-GlutamicAcid Reboxetine Aminoglutethimide Ibandronate Masoprocol L-Methionine Pyruvicacid L-AsparticAcid L-AsparticAcid Furosemide Citalopram Fenoldopam Monobenzone Ethoxzolamide Ethoxzolamide Dofetilide Choriogonadotropinalfa Choriogonadotropinalfa Choriogonadotropinalfa Choriogonadotropinalfa Choriogonadotropinalfa Choriogonadotropinalfa Choriogonadotropinalfa Choriogonadotropinalfa Altretamine L-Lysine Denileukindiftitox Montelukast N-Acetyl-D-glucosamine Allopurinol Gemcitabine Gemcitabine Vidarabine Vidarabine Vidarabine Filgrastim L-Ornithine Dronabinol Guanidine Carbachol Dibucaine Alglucerase Aztreonam Antithymocyteglobulin Tenofovir DornaseAlfa L-Phenylalanine Phosphatidylserine Phosphatidylserine AdefovirDipivoxil Isoflurophate S-Adenosylmethionine ThyrotropinAlfa ThyrotropinAlfa ThyrotropinAlfa Etoposide Pentostatin Aciclovir Teniposide L-Histidine L-Arginine Chlorpromazine L-Asparagine Follitropinbeta Follitropinbeta Follitropinbeta Ethopropazine Pyridoxal Choline Choline Choline Choline Dyphylline Cidofovir Imiglucerase Alitretinoin Daunorubicin Losartan Alpha-LinolenicAcid Anistreplase Alteplase L-Glutamine L-Glutamine Carteolol Hydroxocobalamin Pegfilgrastim Trandolapril Trandolapril Prochlorperazine Simvastatin Glycine Chlorotrianisene Chlorotrianisene Chlorotrianisene Caspofungin Oxyphenonium Sulfametopyrazine Irinotecan Vindesine Roxithromycin Floxuridine Gemtuzumabozogamicin Gemtuzumabozogamicin Thioguanine Trifluridine Trifluridine Urofollitropin Urofollitropin Urofollitropin

Efavirenz Pemetrexed Pemetrexed Calcitriol Dapsone Dapsone Lactulose Lactulose Baclofen Collagenase FolicAcid FolicAcid Theophylline Theophylline Sulfadiazine Sulfadiazine Nafarelin Nafarelin Lidocaine Lidocaine Lindane Dapiprazole Dapiprazole Dapiprazole Dapiprazole Succinylcholine Succinylcholine Succinylcholine Docosanol Docosanol Docosanol Docosanol LipoicAcid LipoicAcid Entecavir Perflutren Perflutren L-Leucine L-Leucine Etanercept Etanercept BotulinumToxinTypeA Hetacillin Hetacillin Hetacillin Sargramostim Sargramostim Sargramostim Enfuvirtide Enfuvirtide Levonorgestrel Levonorgestrel Levonorgestrel Epoetinalfa Thiopental Thiopental Thiopental Thiopental Nelfinavir Nelfinavir Progesterone Progesterone L-Cystine L-Cystine Cinnarizine Carmustine Carmustine L-Isoleucine L-Isoleucine L-Cysteine L-Cysteine Enflurane Enflurane Enflurane Zileuton Amiloride Tenecteplase Tenecteplase Fenfluramine Tetracycline Tetracycline Tetracycline Ceftazidime Ceftazidime Adenine Adenine Ardeparin Ardeparin Ardeparin Ardeparin Ardeparin Metaraminol Metaraminol Ibutilide Ibutilide Cladribine Cladribine Troglitazone Troglitazone Phentolamine Betaxolol Betaxolol Atomoxetine Atomoxetine Mefloquine Mefloquine Mefloquine Esmolol Esmolol Esmolol Esmolol Estrone Bupivacaine Bupivacaine Bupivacaine Rosiglitazone Rosiglitazone L-Carnitine L-Carnitine Methylscopolamine Methylscopolamine Methylscopolamine Rituximab NitricOxide NitricOxide Diltiazem Diltiazem Dexrazoxane Dexrazoxane Dexrazoxane Pirenzepine Testosterone Testosterone Alpha-1-proteinaseinhibitor Flunisolide Flunisolide Hexachlorophene Hexachlorophene Hexachlorophene Sulfisoxazole Sulfisoxazole Sulfisoxazole Menadione Pyridostigmine Pyridostigmine Pyridostigmine Hydroxyzine Hydroxyzine Pamidronate Griseofulvin Betamethasone Inulin Inulin Mitotane Ipratropiumbromide Succinicacid Ramipril Lovastatin Eplerenone Trovafloxacin Trovafloxacin Rasburicase PyridoxalPhosphate PyridoxalPhosphate Midodrine Midodrine Carisoprodol Carisoprodol Carbimazole ValproicAcid ValproicAcid Mefenamicacid Mefenamicacid Reteplase Reteplase Metyrosine Metyrosine Methylergonovine Methylergonovine Arcitumomab Arcitumomab Arcitumomab Arcitumomab Arcitumomab Arcitumomab L-Tryptophan L-Tryptophan VitaminC VitaminC Mazindol Mazindol AminosalicylicAcid AminosalicylicAcid Amitriptyline Beclomethasone Meperidine Meperidine Bleomycin Bleomycin Vasopressin Vasopressin Zolpidem Zolpidem Mometasone Mometasone Sildenafil Butorphanol Butorphanol Butorphanol CalciumAcetate CalciumAcetate Esomeprazole Esomeprazole Esomeprazole Cefotiam Cefotiam Cefotiam Cefotiam Doxylamine Doxylamine Sumatriptan Sumatriptan Oxiconazole Oxiconazole Oxiconazole Timolol Timolol Fenoprofen Lamivudine Oxaliplatin Oxaliplatin Tobramycin Tobramycin Aldesleukin Aldesleukin AntihemophilicFactor AntihemophilicFactor Oseltamivir Modafinil Modafinil Nitroprusside Fluorescein Fluorescein Oxycodone Oxycodone Cyproheptadine NADH NADH Spermine Spermine Phenytoin Phenytoin Lansoprazole Lansoprazole Mephenytoin Mephenytoin Mephenytoin Enalapril Raloxifene Natalizumab Natalizumab Natalizumab Natalizumab Amsacrine Amsacrine Amsacrine Fluoxetine Fluoxetine Amodiaquine Amodiaquine Atenolol Atenolol Alfuzosin Alfuzosin Alfuzosin Pramipexole Icosapent Naltrexone Naltrexone Sucralfate Sucralfate Zanamivir Zanamivir Dolasetron Dolasetron Dolasetron Dolasetron Dolasetron Dolasetron Imatinib Lisinopril L-GlutamicAcid L-GlutamicAcid Reboxetine Reboxetine Reboxetine Tamoxifen Tamoxifen Tamoxifen Interferonbeta-1a Interferonbeta-1a Interferonbeta-1a Protriptyline Aminoglutethimide Aminoglutethimide Verteporfin Verteporfin Gonadorelin Gonadorelin Gonadorelin Gonadorelin Lorazepam Lorazepam Prilocaine Prilocaine Cyanocobalamin Haloperidol Risperidone Streptokinase Foscarnet Foscarnet Oxcarbazepine Oxcarbazepine Oxcarbazepine Azithromycin Azithromycin L-Methionine L-Methionine Pyruvicacid Mupirocin Mupirocin L-AsparticAcid L-AsparticAcid Dicloxacillin Chloroquine Chloroquine CoagulationFactorIX CoagulationFactorIX CoagulationFactorIX Furosemide Furosemide Citalopram Citalopram Citalopram Clavulanate Clavulanate Atropine Atropine Fenoldopam Ritonavir Ritonavir Cyclosporine Cyclosporine Interferonbeta-1b Interferonbeta-1b Monobenzone Monobenzone Verapamil Verapamil Tramadol Tramadol L-Valine L-Valine Bexarotene Bexarotene Nimodipine Nimodipine Cevimeline Cevimeline Cevimeline Indomethacin Choriogonadotropinalfa Choriogonadotropinalfa Stavudine Stavudine Altretamine L-Lysine L-Lysine Denileukindiftitox Denileukindiftitox Denileukindiftitox Benazepril Benazepril Benazepril Oxytocin Loratadine Loratadine Indinavir Indinavir Chlorzoxazone Chlorzoxazone Chlorzoxazone Bosentan Trimethoprim Trimethoprim Clotrimazole L-Threonine L-Threonine Acarbose Montelukast Montelukast Warfarin Anakinra Anakinra Interferongamma-1b Interferongamma-1b Tirofiban Tirofiban N-Acetyl-D-glucosamine N-Acetyl-D-glucosamine Fluphenazine Milrinone Milrinone Chlorambucil Scopolamine Scopolamine HalobetasolPropionate HalobetasolPropionate HalobetasolPropionate HalobetasolPropionate HalobetasolPropionate Allopurinol Methoxamine Mebendazole Gemcitabine Gemcitabine Galantamine Galantamine Dexmedetomidine Dexmedetomidine Vidarabine Vidarabine Filgrastim Propranolol Propranolol Chlorthalidone Tenoxicam Tenoxicam Tenoxicam Oprelvekin Valaciclovir Valaciclovir Valaciclovir Codeine Nitrofurazone L-Ornithine Deferoxamine Deferoxamine Dronabinol Metaxalone Metaxalone Metaxalone Metaxalone Metaxalone Metaxalone Metaxalone Metaxalone Riboflavin Riluzole Riluzole Xanthophyll Xanthophyll Guanidine Guanidine Icodextrin Icodextrin Carbachol Carbachol Rofecoxib Voriconazole Mirtazapine Brimonidine Brimonidine Alendronate Dibucaine Dibucaine Halazepam Halazepam Halazepam Halazepam Alglucerase Alglucerase Alglucerase Alglucerase Piperacillin Piperacillin CarboprostTromethamine Nabumetone Carbamazepine Carbamazepine Pentamidine Aztreonam Aztreonam Sotalol Sotalol Pentobarbital Pentobarbital Torasemide Torasemide Torasemide Gadodiamide Gadodiamide Gadodiamide Gadodiamide Gadodiamide Gadodiamide Gadodiamide Gadodiamide Gadodiamide Gadodiamide Gadodiamide Gadodiamide Gadodiamide Gadodiamide Gadodiamide Antithymocyteglobulin Midazolam Midazolam Midazolam Hyaluronidase Cefmetazole Cefmetazole Idoxuridine Cefalotin Cefalotin Cefalotin Etomidate Etomidate Etomidate Tenofovir Tenofovir Pentazocine Vincristine Vincristine DornaseAlfa DornaseAlfa Cetuximab Cisplatin Cisplatin Cisplatin Flurazepam Flurazepam Ethosuximide Ethosuximide Fluvoxamine Fluvoxamine Fluvoxamine Vinblastine Vinblastine Chloramphenicol Chloramphenicol Cetirizine Cetirizine Pegaspargase Pegaspargase Pegaspargase Pegaspargase Propylthiouracil Propylthiouracil Hyoscyamine Hyoscyamine Trastuzumab L-Phenylalanine L-Phenylalanine Nisoldipine Nisoldipine Apomorphine Metformin Cetrorelix Cetrorelix Hydroflumethiazide Hydroflumethiazide Hydroflumethiazide Hydroflumethiazide Valrubicin Valrubicin Valrubicin Valrubicin Valrubicin Valrubicin Metoprolol Metoprolol Desmopressin Desmopressin Phenelzine Sulpiride Sulpiride Argatroban Trihexyphenidyl Trihexyphenidyl Cimetidine Cimetidine Digoxin Digoxin Demeclocycline Goserelin Goserelin Goserelin Morphine Morphine Becaplermin Oxytetracycline Oxytetracycline Clofibrate Clofibrate Bendroflumethiazide Bendroflumethiazide Sulfanilamide Sulfanilamide Phenindione Fosinopril Fosinopril Diflorasone Diflorasone Diflorasone Diflorasone Diflorasone Cefdinir Cefdinir Cefdinir Cefdinir Carbenicillin L-Citrulline Nitroglycerin Nitroglycerin Nitroglycerin Phosphatidylserine Phosphatidylserine AdefovirDipivoxil Topiramate Topiramate Sufentanil Sufentanil Sufentanil Sufentanil Tretinoin GallamineTriethiodide GallamineTriethiodide Alemtuzumab Daptomycin Flurbiprofen Flurbiprofen VitaminA Fluorouracil Fluorouracil Fluorouracil Nortriptyline Nortriptyline Calcidiol Nicardipine Nicardipine Nicardipine Hydromorphone Tetrahydrofolicacid Tetrahydrofolicacid Atracurium Atracurium Atracurium Atracurium Atracurium Atracurium Atracurium Atracurium Atracurium Olopatadine Olopatadine Moxifloxacin Toremifene Toremifene Reserpine Isoflurophate Isoflurophate S-Adenosylmethionine S-Adenosylmethionine ThyrotropinAlfa Megestrol Megestrol Urokinase Urokinase Etoposide Etoposide Dextromethorphan Dextromethorphan Pentostatin Pentostatin Sulfasalazine Trazodone Terfenadine Terfenadine Valsartan Valsartan Ticlopidine Aciclovir Aciclovir Doxazosin Doxazosin Alfentanil Alfentanil Alfentanil Alfentanil Alfentanil Adalimumab Adalimumab Nafcillin Pregabalin Pregabalin Mitomycin Mitomycin Mitomycin Teniposide Teniposide Prazosin Prazosin Pantoprazole Pantoprazole Pantoprazole Pyrazinamide Pyrazinamide L-Histidine L-Histidine Olanzapine Vinorelbine Vinorelbine L-Arginine Doxycycline Clobazam Clobazam VitaminE VitaminE Secretin Secretin Nizatidine Nizatidine Nizatidine Nizatidine Nizatidine Chlorpromazine Liothyronine Liothyronine Ranolazine Ranolazine Tolmetin Tolmetin Triprolidine Triprolidine Infliximab L-Asparagine L-Asparagine Follitropinbeta Ethopropazine Imipramine Imipramine Pralidoxime Moricizine Moricizine Moricizine Moricizine Moricizine Prednisone Mannitol Mannitol Thiethylperazine Thiethylperazine Propantheline Propantheline Flutamide Flutamide Streptozocin Pyridoxal Pyridoxal Glutathione Glutathione Glutathione Glutathione Benztropine Choline Choline Choline Nystatin Erlotinib Candoxatril Candoxatril Candoxatril Bentiromide Bentiromide Bentiromide Cefotaxime Cefotaxime Porfimer Porfimer Porfimer Alprazolam Alprazolam Alprazolam Sulfamethizole Sulfamethizole Dyphylline Dyphylline Dyphylline Dyphylline Dyphylline Dyphylline Tripelennamine Tripelennamine Cidofovir Somatropinrecombinant Somatropinrecombinant Imiglucerase Imiglucerase Imiglucerase Imiglucerase Entacapone Entacapone Entacapone Entacapone Cephaloglycin Cephaloglycin Penciclovir Penciclovir Penciclovir Eptifibatide Diatrizoate Diatrizoate Clodronate Clozapine Nicotine Pefloxacin Pefloxacin Pefloxacin Methotrexate Methotrexate Triflupromazine Alitretinoin Alitretinoin Daunorubicin Daunorubicin Loracarbef Loracarbef Loracarbef Alefacept Alefacept Alefacept Diethylcarbamazine Procaine Methylphenidate Secobarbital Nilutamide Nilutamide Nilutamide Nilutamide Malathion Desogestrel Dihydroergotamine Mexiletine Mexiletine Mexiletine Clemastine Clemastine Nitazoxanide Nitazoxanide AminocaproicAcid AminocaproicAcid Losartan Losartan AmphotericinB Zoledronate Cyclothiazide Cyclothiazide Nitrofurantoin Alpha-LinolenicAcid Alpha-LinolenicAcid Zafirlukast AcetohydroxamicAcid Methadone Rocuronium Rocuronium Rocuronium Rocuronium Rocuronium Rocuronium Rocuronium Rocuronium Rocuronium Acamprosate Acamprosate Anistreplase Anistreplase Remikiren Remikiren Remikiren Remikiren Remikiren Remikiren Alteplase Alteplase Mesalazine Muromonab Muromonab Celecoxib Ertapenem Gentamicin Gentamicin Gefitinib Ergocalciferol Minoxidil Minaprine Minaprine Succimer Succimer Succimer Pravastatin Pravastatin Cefixime Cefixime Cefixime Perindopril Perindopril Bisoprolol Bisoprolol Bisoprolol Paroxetine Paroxetine Leuprolide Leuprolide Creatine Creatine Creatine Piperazine Piperazine Propoxyphene Latanoprost Chlorpropamide L-Glutamine L-Glutamine Fluconazole Fluconazole Darbepoetinalfa Temazepam Temazepam Temazepam Remoxipride Remoxipride Remoxipride Remoxipride Sulindac Sulindac Guanabenz Carteolol Carteolol Carteolol Bevacizumab Bevacizumab Ergotamine Gadoteridol Gadoteridol Gadoteridol Gadoteridol Gadoteridol Gadoteridol Gadoteridol Gadoteridol Gadoteridol Gadoteridol Gadoteridol Gadoteridol Gadoteridol Gadoteridol Gadoteridol Acitretin Acitretin Triamcinolone Triamcinolone Niacin Hydroxocobalamin Hydroxocobalamin Pegvisomant Pegvisomant Adinazolam Adinazolam Adinazolam GadobenateDimeglumine GadobenateDimeglumine GadobenateDimeglumine GadobenateDimeglumine GadobenateDimeglumine GadobenateDimeglumine GadobenateDimeglumine GadobenateDimeglumine GadobenateDimeglumine GadobenateDimeglumine GadobenateDimeglumine GadobenateDimeglumine GadobenateDimeglumine GadobenateDimeglumine GadobenateDimeglumine GadobenateDimeglumine GadobenateDimeglumine GadobenateDimeglumine Nevirapine Cisapride Cisapride Cisapride Thioridazine Interferonalfacon-1 Interferonalfacon-1 Interferonalfacon-1 Serumalbumin Serumalbumin Serumalbumin Raltitrexed Raltitrexed Enoxacin Enoxacin SodiumTetradecylSulfate Vancomycin Vancomycin Buspirone Buspirone Gadopentetatedimeglumine Gadopentetatedimeglumine Gadopentetatedimeglumine Gadopentetatedimeglumine Gadopentetatedimeglumine Gadopentetatedimeglumine Gadopentetatedimeglumine Gadopentetatedimeglumine Gadopentetatedimeglumine Gadopentetatedimeglumine Gadopentetatedimeglumine Gadopentetatedimeglumine Gadopentetatedimeglumine Gadopentetatedimeglumine Gadopentetatedimeglumine Gadopentetatedimeglumine Gadopentetatedimeglumine Tazarotene Tazarotene Norgestrel Norgestrel Pegfilgrastim Labetalol Labetalol Carbidopa Carbidopa Carbidopa Ampicillin Octreotide Octreotide Piroxicam Piroxicam Piroxicam Disopyramide Disopyramide Disopyramide Erythromycin Erythromycin Tacrine Tacrine Thiabendazole Venlafaxine Pentagastrin Alprostadil Alprostadil Trandolapril Trandolapril Spironolactone Acetaminophen Acetaminophen Pyridoxine Pyridoxine Pyridoxine Methimazole Methimazole Methazolamide Methazolamide Lymecycline Glimepiride Glimepiride Prochlorperazine Prochlorperazine Capromab Capromab Capromab Fludrocortisone Tamsulosin Trimipramine Trimipramine Thiamine Simvastatin Gadoversetamide Gadoversetamide Gadoversetamide Gadoversetamide Gadoversetamide Gadoversetamide Gadoversetamide Gadoversetamide Droperidol Droperidol Ropivacaine Ropivacaine Ropivacaine Ropivacaine Lamotrigine Lamotrigine Sermorelin Sermorelin Sermorelin Dicyclomine Glycine Glycine Divalproexsodium Divalproexsodium Divalproexsodium Divalproexsodium Famciclovir Famciclovir Tolnaftate Tolnaftate Astemizole Astemizole Albendazole Albendazole Aminohippurate Aminohippurate Nicergoline Clorazepate Clorazepate Clorazepate Clorazepate Etodolac Etodolac Etodolac Etodolac Duloxetine Duloxetine Bacitracin Bacitracin Doxapram Doxapram Doxapram Cephalexin Cephalexin Rifabutin Rifabutin Methohexital Methohexital Methoxsalen Loxapine Loxapine Menotropin Isoflurane Isoflurane Isoflurane Chlorotrianisene Chlorotrianisene Chlorotrianisene Triamterene Triamterene Oxyphenonium Sulfametopyrazine Delavirdine Ketorolac Ketorolac Irinotecan Irinotecan Vindesine Vindesine Vindesine Clonidine Clonidine Mecamylamine Amikacin Amikacin Cabergoline Cabergoline Amlodipine Daclizumab Daclizumab Leucovorin Leucovorin Roxithromycin Roxithromycin Roxithromycin Candesartan Candesartan Tolcapone Tolcapone Tolcapone Nateglinide Nateglinide Nateglinide Efalizumab Efalizumab Efalizumab Cerivastatin Cerivastatin Cerivastatin Cerivastatin Trimethadione Trimethadione Trimethadione Trimethadione Trimethadione Floxuridine Floxuridine Ciprofloxacin Ciprofloxacin Cefmenoxime Cefmenoxime Cefmenoxime Cefpiramide Cefpiramide Cefpiramide Cefpiramide Cefpiramide Isoetharine Isoetharine Amphetamine Tetrahydrobiopterin Ethambutol Isradipine Isradipine Clopidogrel Flucloxacillin Flucloxacillin Palifermin Thioguanine Thioguanine Epirubicin Epirubicin Epirubicin Epirubicin Trifluridine Phentermine Diclofenac Diclofenac Meropenem Meropenem Abciximab L-Proline L-Proline Urofollitropin Medrysone Medrysone Lisuride Colistin Nitisinone Nitisinone Nitisinone Nitisinone Zolmitriptan Zolmitriptan Zolmitriptan

Efavirenz Pemetrexed Pemetrexed Pemetrexed Calcitriol Calcitriol Dapsone Dapsone Lactulose Baclofen Collagenase Collagenase FolicAcid FolicAcid Theophylline Sulfadiazine Lidocaine Lidocaine Lindane Lindane Succinylcholine Entecavir Perflutren L-Leucine L-Leucine Etanercept Etanercept BotulinumToxinTypeA Sargramostim Sargramostim Sargramostim Sargramostim Enfuvirtide Levonorgestrel Levonorgestrel Epoetinalfa Thiopental Thiopental Nelfinavir Nelfinavir Progesterone Progesterone L-Cystine Carmustine Tolazoline L-Isoleucine L-Isoleucine L-Cysteine Enflurane Enflurane Amiloride Amiloride Tenecteplase Tenecteplase Imiquimod Fenfluramine Tetracycline Tetracycline Adenine Adenine Methysergide Cladribine Cladribine Troglitazone Troglitazone Phentolamine Betaxolol Mefloquine Esmolol Esmolol Esmolol Estrone Estrone Bupivacaine Bupivacaine Bupivacaine Bupivacaine Rosiglitazone L-Carnitine L-Carnitine Methylscopolamine Rituximab Fluorometholone NitricOxide NitricOxide Diltiazem Dexrazoxane Testosterone Testosterone Testosterone Alpha-1-proteinaseinhibitor Alpha-1-proteinaseinhibitor Flunisolide Flunisolide Hexachlorophene Hexachlorophene Hexachlorophene Sulfisoxazole Sulfisoxazole Sulfisoxazole Menadione Pyridostigmine Hydroxyzine Pamidronate Pamidronate Betamethasone Betamethasone Inulin Ipratropiumbromide Succinicacid Succinicacid Lovastatin Trovafloxacin Rasburicase PyridoxalPhosphate PyridoxalPhosphate Midodrine Carisoprodol Carisoprodol Carbimazole Carbimazole Carbimazole Carbimazole Carbimazole Carbimazole Carbimazole Carbimazole Carbimazole Carbimazole ValproicAcid Reteplase Reteplase Metyrosine Metyrosine Metyrosine Methylergonovine L-Tryptophan L-Tryptophan VitaminC VitaminC Mazindol AminosalicylicAcid AminosalicylicAcid Amitriptyline Beclomethasone Meperidine Bleomycin Bleomycin Bleomycin Vasopressin Zolpidem Zolpidem Mometasone Sildenafil Butorphanol Butorphanol InterferonAlfa-2a,Recombinant InterferonAlfa-2a,Recombinant InterferonAlfa-2a,Recombinant CalciumAcetate CalciumAcetate Esomeprazole Esomeprazole Cefotiam Cefotiam Sumatriptan Bortezomib Timolol Timolol Fenoprofen Lamivudine Oxaliplatin Oxaliplatin Oxaliplatin Acetohexamide Acetohexamide Tobramycin Aldesleukin Aldesleukin Aldesleukin AntihemophilicFactor AntihemophilicFactor Oseltamivir Modafinil Modafinil Nitroprusside Fluorescein Fluorescein Oxycodone Cyproheptadine NADH Spermine Phenytoin Phenytoin Lansoprazole Lansoprazole Mephenytoin Enalapril Raloxifene Natalizumab Natalizumab Natalizumab Natalizumab Natalizumab Basiliximab Fluoxetine Fluoxetine Amodiaquine Atenolol Atenolol Pramipexole Icosapent Naltrexone Sucralfate Zanamivir Zanamivir Dextrothyroxine Dextrothyroxine Dextrothyroxine Dextrothyroxine Dextrothyroxine Dextrothyroxine Dextrothyroxine Dextrothyroxine Imatinib L-GlutamicAcid L-GlutamicAcid Reboxetine Tamoxifen Tamoxifen Tamoxifen Interferonbeta-1a Interferonbeta-1a Interferonbeta-1a Interferonbeta-1a Protriptyline Aminoglutethimide Verteporfin Gonadorelin Gonadorelin Gonadorelin Gonadorelin Gonadorelin Lorazepam Ibandronate Prilocaine Masoprocol Cyanocobalamin Haloperidol Risperidone Streptokinase Ceruletide Ceruletide Foscarnet Foscarnet Oxcarbazepine Oxcarbazepine L-Methionine L-Methionine Pyruvicacid Pyruvicacid Mupirocin Mupirocin L-AsparticAcid L-AsparticAcid Chloroquine CoagulationFactorIX CoagulationFactorIX CoagulationFactorIX Furosemide Furosemide Citalopram Citalopram Clavulanate Atropine Fenoldopam Fenoldopam Ritonavir Cyclosporine Interferonbeta-1b Interferonbeta-1b Interferonbeta-1b Monobenzone Monobenzone Ethoxzolamide Ethoxzolamide Verapamil Tramadol Tramadol L-Valine Bexarotene Bexarotene Bexarotene Nimodipine Indomethacin Stavudine Stavudine Altretamine L-Lysine Denileukindiftitox Denileukindiftitox Denileukindiftitox Benazepril Benazepril Oxytocin Indinavir Bosentan Trimethoprim Clotrimazole L-Threonine Acarbose Montelukast Montelukast Warfarin Anakinra Anakinra Interferongamma-1b Interferongamma-1b Tirofiban Tirofiban N-Acetyl-D-glucosamine N-Acetyl-D-glucosamine Fluphenazine Milrinone Milrinone Chlorambucil Scopolamine Scopolamine HalobetasolPropionate HalobetasolPropionate HalobetasolPropionate HalobetasolPropionate HalobetasolPropionate Allopurinol Methoxamine Mebendazole Gemcitabine Gemcitabine Galantamine Galantamine Dexmedetomidine Vidarabine Filgrastim Propranolol Propranolol Chlorthalidone Tenoxicam Dipivefrin Dipivefrin Dipivefrin Dipivefrin Oprelvekin Valaciclovir Valaciclovir Codeine Nitrofurazone L-Ornithine L-Ornithine Deferoxamine Deferoxamine Deferoxamine Dronabinol Riboflavin Riluzole Xanthophyll Guanidine Icodextrin Grepafloxacin Grepafloxacin Carbachol Carbachol Rofecoxib Voriconazole Abarelix Abarelix Abarelix Abarelix Abarelix Abarelix Mirtazapine Brimonidine Alendronate Alendronate Dibucaine Alglucerase Alglucerase Alglucerase Piperacillin CarboprostTromethamine Dicumarol Carbamazepine Carbamazepine Carbamazepine Sotalol Sotalol Pentobarbital Pentobarbital Torasemide Torasemide Gadodiamide Gadodiamide Gadodiamide Gadodiamide Gadodiamide Gadodiamide Gadodiamide Gadodiamide Gadodiamide Gadodiamide Gadodiamide Antithymocyteglobulin Antithymocyteglobulin Midazolam Midazolam Hyaluronidase Idoxuridine Cefalotin Etomidate Etomidate Etomidate Tenofovir Tenofovir Pentazocine BotulinumToxinTypeB BotulinumToxinTypeB BotulinumToxinTypeB Vincristine Vincristine DornaseAlfa DornaseAlfa Cetuximab Cetuximab Cisplatin Cisplatin Cisplatin Cisplatin Ethosuximide Fluvoxamine Fluvoxamine Vinblastine Vinblastine Vinblastine Chloramphenicol Chloramphenicol Propylthiouracil Propylthiouracil Propylthiouracil Propylthiouracil Propylthiouracil Propylthiouracil Propylthiouracil Propylthiouracil Propylthiouracil Propylthiouracil Propylthiouracil Propylthiouracil Hyoscyamine Hyoscyamine Trastuzumab Trastuzumab L-Phenylalanine Apomorphine Metformin Hydroflumethiazide Hydroflumethiazide Valrubicin Valrubicin Valrubicin Metoprolol Metoprolol Desmopressin Phenelzine Sulpiride Argatroban Trihexyphenidyl Trihexyphenidyl Cimetidine Digoxin Goserelin Goserelin Goserelin Goserelin Goserelin Goserelin Morphine Becaplermin Becaplermin Oxytetracycline Clofibrate Clofibrate Bendroflumethiazide Bendroflumethiazide Sulfanilamide Phenindione Diflorasone Diflorasone Diflorasone Diflorasone Diflorasone L-Citrulline Nitroglycerin Nitroglycerin Nitroglycerin Nitroglycerin Phosphatidylserine AdefovirDipivoxil Topiramate Topiramate Sufentanil Sufentanil Sufentanil Sufentanil Tretinoin Tretinoin Tretinoin GallamineTriethiodide Alemtuzumab Daptomycin Flurbiprofen Flurbiprofen Betazole Betazole VitaminA Fluorouracil Fluorouracil Fluorouracil Fluorouracil Nortriptyline Ziprasidone Calcidiol Calcidiol Nicardipine Nicardipine Hydromorphone Hydromorphone Tetrahydrofolicacid Atracurium Atracurium Moxifloxacin Toremifene Toremifene Reserpine Isoflurophate S-Adenosylmethionine S-Adenosylmethionine ThyrotropinAlfa ThyrotropinAlfa ThyrotropinAlfa ThyrotropinAlfa ThyrotropinAlfa Furazolidone Megestrol Megestrol Urokinase Etoposide Etoposide Dextromethorphan Pentostatin Sulfasalazine Trazodone Terfenadine Valsartan Ticlopidine Aciclovir Aciclovir Doxazosin Alfentanil Alfentanil Pregabalin Pregabalin Mitomycin Mitomycin Mitomycin Teniposide Prazosin Prazosin Pantoprazole Pyrazinamide L-Histidine L-Histidine Olanzapine Vinorelbine Vinorelbine L-Arginine Doxycycline Clobazam Clobazam Clobazam VitaminE VitaminE Secretin Secretin Chlorpromazine Liothyronine Liothyronine Liothyronine Liothyronine Liothyronine Liothyronine Liothyronine Liothyronine Liothyronine Liothyronine Liothyronine Liothyronine Liothyronine Liothyronine Liothyronine Liothyronine Liothyronine Liothyronine Liothyronine Liothyronine Liothyronine Tolmetin Tolmetin Infliximab L-Asparagine Follitropinbeta Follitropinbeta Follitropinbeta Follitropinbeta Ethopropazine Imipramine Imipramine Pralidoxime Prednisone Prednisone Mannitol Mannitol Flutamide Flutamide Flutamide Flutamide Streptozocin Streptozocin Pyridoxal Pyridoxal Glutathione Glutathione Choline Choline Choline Erlotinib Bentiromide Bentiromide Porfimer Porfimer Porfimer Alprazolam Alprazolam Alprazolam Alprazolam Dyphylline Dyphylline Dyphylline Dyphylline Dyphylline Dyphylline Tripelennamine Cidofovir Somatropinrecombinant Somatropinrecombinant Somatropinrecombinant Somatropinrecombinant Somatropinrecombinant Imiglucerase Imiglucerase Imiglucerase Cycloserine Diatrizoate Diatrizoate Agalsidasebeta Agalsidasebeta Agalsidasebeta Agalsidasebeta Clodronate Clozapine Nicotine Pefloxacin Methotrexate Methotrexate Methotrexate Alitretinoin Alitretinoin Alitretinoin Alitretinoin Alitretinoin Oxandrolone Oxandrolone Oxandrolone Daunorubicin Alefacept Alefacept Procaine Methylphenidate Methylphenidate Nilutamide Nilutamide Malathion Sorafenib Sorafenib Desogestrel Mexiletine Nitazoxanide Nitazoxanide AminocaproicAcid AminocaproicAcid Losartan AmphotericinB Nitrofurantoin Alpha-LinolenicAcid Alpha-LinolenicAcid AcetohydroxamicAcid Methadone Rocuronium Rocuronium Rocuronium Acamprosate Acamprosate Anistreplase Anistreplase Alteplase Alteplase Muromonab Muromonab Muromonab Celecoxib Ertapenem Gentamicin Gefitinib Ergocalciferol Minoxidil Minaprine Minaprine Succimer Succimer Pravastatin Cefixime Perindopril Paroxetine Leuprolide Leuprolide Leuprolide Leuprolide Creatine Creatine Creatine Creatine Ethchlorvynol Ethchlorvynol Piperazine Latanoprost L-Glutamine L-Glutamine Fluconazole Darbepoetinalfa Temazepam Temazepam Sulindac Sulindac Carteolol Amoxapine Bevacizumab Bevacizumab Ergotamine Gadoteridol Gadoteridol Gadoteridol Gadoteridol Gadoteridol Gadoteridol Gadoteridol Gadoteridol Gadoteridol Gadoteridol Gadoteridol Gadoteridol Acitretin Triamcinolone Niacin Hydroxocobalamin Pegvisomant Pegvisomant Pegvisomant Pegvisomant Pegvisomant GadobenateDimeglumine GadobenateDimeglumine GadobenateDimeglumine GadobenateDimeglumine GadobenateDimeglumine GadobenateDimeglumine GadobenateDimeglumine GadobenateDimeglumine GadobenateDimeglumine GadobenateDimeglumine GadobenateDimeglumine GadobenateDimeglumine Tranylcypromine Nevirapine Cisapride Thioridazine Raltitrexed Raltitrexed Raltitrexed Raltitrexed SodiumTetradecylSulfate Buspirone Buspirone Gadopentetatedimeglumine Gadopentetatedimeglumine Gadopentetatedimeglumine Gadopentetatedimeglumine Gadopentetatedimeglumine Gadopentetatedimeglumine Gadopentetatedimeglumine Gadopentetatedimeglumine Gadopentetatedimeglumine Gadopentetatedimeglumine Norgestrel Norgestrel Pegfilgrastim Labetalol Carbidopa Carbidopa Ampicillin Octreotide Octreotide Octreotide Piroxicam Piroxicam Disopyramide Mycophenolatemofetil Mycophenolatemofetil Mycophenolatemofetil Erythromycin Erythromycin Tacrine Tacrine Thiabendazole Venlafaxine Pentagastrin Alprostadil Alprostadil Spironolactone Acetaminophen Acetaminophen Pyridoxine Pyridoxine Pyridoxine Methimazole Methimazole Methimazole Methimazole Methimazole Methimazole Methimazole Methimazole Methimazole Methimazole Methimazole Lymecycline Glimepiride Capromab Capromab Capromab Capromab Capromab Fludrocortisone Tamsulosin Trimipramine Thiamine Thiamine Simvastatin Gadoversetamide Gadoversetamide Gadoversetamide Gadoversetamide Gadoversetamide Droperidol Ropivacaine Ropivacaine Ropivacaine Ropivacaine Lamotrigine Sermorelin Sermorelin Glycine InterferonAlfa-2b,Recombinant InterferonAlfa-2b,Recombinant InterferonAlfa-2b,Recombinant InterferonAlfa-2b,Recombinant Famciclovir Albendazole Albendazole Aminohippurate Nicergoline Nicergoline Clorazepate Etodolac Duloxetine Bacitracin Cephalexin Cephalexin Rifabutin Methohexital Methoxsalen Methoxsalen Menotropin Isoflurane Isoflurane Chlorotrianisene Chlorotrianisene Chlorotrianisene Triamterene Triamterene Caspofungin Oxyphenonium Oxyphenonium Delavirdine Ketorolac Ketorolac Irinotecan Irinotecan Irinotecan Vindesine Vindesine Vindesine Clonidine Clonidine Mecamylamine Amikacin Cabergoline Cabergoline Daclizumab Daclizumab Leucovorin Leucovorin Leucovorin Leucovorin Roxithromycin Candesartan Efalizumab Cerivastatin Cerivastatin Floxuridine Floxuridine Ciprofloxacin Pimecrolimu Isoetharine Isoetharine Amphetamine Tetrahydrobiopterin Ethambutol Isradipine Isradipine Flucloxacillin Palifermin Thioguanine Thioguanine Thioguanine Thioguanine Epirubicin Epirubicin Epirubicin Epirubicin Trifluridine Trifluridine Trifluridine Phentermine Phentermine Diclofenac Diclofenac Meropenem Abciximab L-Proline Urofollitropin Urofollitropin Urofollitropin Urofollitropin Urofollitropin Bivalirudin Medrysone Medrysone Colistin

Levonorgestrel Thiopental Carmustine Enflurane Tenecteplase Tenecteplase Metaraminol Mefloquine Fluorometholone Fluorometholone Fluorometholone Alpha-1-proteinaseinhibitor Hexachlorophene Rasburicase Carisoprodol Carbimazole ValproicAcid Reteplase Reteplase Metyrosine Methylergonovine Sumatriptan Oxaliplatin AntihemophilicFactor AntihemophilicFactor Oseltamivir Cyproheptadine Amsacrine Fluoxetine Pramipexole Zanamivir Streptokinase Ceruletide Ceruletide L-AsparticAcid Dicloxacillin Ethoxzolamide Ethoxzolamide Ethoxzolamide Altretamine Oxytocin Warfarin Filgrastim Oprelvekin Piperacillin Dicumarol Dicumarol Hyaluronidase Cefmetazole Pentazocine Vincristine Cisplatin Cetirizine Desmopressin Argatroban Argatroban Argatroban Argatroban Trihexyphenidyl Phosphatidylserine Tretinoin Tretinoin Alemtuzumab Fluorouracil Nicardipine Urokinase Etoposide Ticlopidine Lepirudin Lepirudin Lepirudin Aciclovir Mitomycin Teniposide Prednisone Flutamide Streptozocin Cefotaxime Pefloxacin Methotrexate Alitretinoin Alitretinoin Daunorubicin Daunorubicin Dihydroergotamine AminocaproicAcid Zoledronate Anistreplase Anistreplase Alteplase Alteplase Pipobroman Pipobroman Pipobroman Ergocalciferol Pravastatin Leuprolide Chlorpropamide Chlorpropamide Temazepam Amoxapine Bevacizumab Buspirone Pegfilgrastim Labetalol TranexamicAcid TranexamicAcid TranexamicAcid TranexamicAcid Carbidopa Acetaminophen Dicyclomine Dicyclomine Dicyclomine Etodolac Ketorolac Vindesine Cabergoline Leucovorin Gemtuzumabozogamicin Gemtuzumabozogamicin Isradipine Epirubicin Trifluridine Phentermine Diclofenac Diclofenac Meropenem

Calcitriol Collagenase L-Leucine Levonorgestrel Carmustine L-Cysteine Amiloride Tenecteplase Tenecteplase Tenecteplase Tenecteplase Troglitazone NitricOxide Testosterone Betamethasone PyridoxalPhosphate PyridoxalPhosphate PyridoxalPhosphate Reteplase Reteplase Reteplase Reteplase Mazindol AminosalicylicAcid Doxylamine Doxylamine Bortezomib Oxaliplatin Aldesleukin Spermine Spermine Spermine Spermine Spermine Spermine Spermine Spermine Atenolol L-GlutamicAcid Tamoxifen Interferonbeta-1a Aminoglutethimide Masoprocol Masoprocol Masoprocol L-Methionine Interferonbeta-1b Monobenzone Verapamil Indomethacin L-Lysine L-Threonine Methoxamine Propranolol Nitrofurazone L-Ornithine L-Ornithine L-Ornithine L-Ornithine L-Ornithine L-Ornithine L-Ornithine L-Ornithine L-Ornithine L-Ornithine L-Ornithine L-Ornithine L-Ornithine L-Ornithine Dicumarol DornaseAlfa Vinblastine Propylthiouracil L-Phenylalanine Nisoldipine Apomorphine Metoprolol Becaplermin L-Citrulline Tretinoin Tretinoin S-Adenosylmethionine S-Adenosylmethionine S-Adenosylmethionine S-Adenosylmethionine L-Histidine L-Arginine VitaminE Secretin Liothyronine L-Asparagine Mannitol Flutamide Flutamide Streptozocin Pyridoxal Glutathione Porfimer Nicotine Dihydroergotamine Anistreplase Anistreplase Anistreplase Anistreplase Alteplase Alteplase Alteplase Alteplase Celecoxib Minoxidil Bisoprolol L-Glutamine Sulindac Acitretin Piroxicam Pentagastrin Alprostadil Methimazole Fludrocortisone Nicergoline Methoxsalen Sulfametopyrazine Irinotecan Vindesine Cerivastatin

Lactulose IntravenousImmunoglobulin IntravenousImmunoglobulin IntravenousImmunoglobulin IntravenousImmunoglobulin IntravenousImmunoglobulin IntravenousImmunoglobulin IntravenousImmunoglobulin Entecavir Levonorgestrel Nelfinavir Cladribine Alpha-1-proteinaseinhibitor Betamethasone Carbimazole ValproicAcid ValproicAcid ValproicAcid Beclomethasone Fluoxetine Interferonbeta-1a Interferonbeta-1b Monobenzone Chlorzoxazone Chlorzoxazone Bosentan Anakinra Interferongamma-1b Vidarabine Dipivefrin DornaseAlfa Chloramphenicol Becaplermin Palivizumab Palivizumab Palivizumab Palivizumab Palivizumab Valsartan Anidulafungin Anidulafungin Anidulafungin Follitropinbeta Imipramine Imipramine Pyridoxal Bentiromide Cephaloglycin Cephaloglycin Cephaloglycin Clodronate Clodronate Minoxidil Minoxidil Metolazone Metolazone Metolazone Propoxyphene Fluconazole Guanabenz Acitretin Nevirapine Carbidopa Carbidopa Spironolactone Methazolamide Methazolamide Methazolamide Famciclovir Bacitracin Caspofungin Pimecrolimu Isoetharine Isoetharine Isradipine Phentermine Medrysone

Efavirenz Efavirenz Efavirenz Pemetrexed Pemetrexed Pemetrexed Calcitriol Calcitriol Calcitriol Dapsone Dapsone Dapsone SalmonCalcitonin SalmonCalcitonin SalmonCalcitonin SalmonCalcitonin SalmonCalcitonin Lactulose Lactulose Lactulose Baclofen Baclofen Baclofen Collagenase Collagenase Collagenase FolicAcid FolicAcid FolicAcid Theophylline Theophylline Clofarabine Clofarabine Clofarabine Clofarabine Sulfadiazine Sulfadiazine Nafarelin Nafarelin Lidocaine Lidocaine Lidocaine Lindane Lindane Oxacillin Oxacillin Succinylcholine Succinylcholine Succinylcholine Docosanol Docosanol Docosanol Docosanol Entecavir Entecavir Entecavir Perflutren Perflutren Perflutren Perflutren Perflutren Perflutren L-Leucine L-Leucine Etanercept Etanercept Etanercept BotulinumToxinTypeA BotulinumToxinTypeA BotulinumToxinTypeA BotulinumToxinTypeA BotulinumToxinTypeA BotulinumToxinTypeA Sargramostim Sargramostim Sargramostim Enfuvirtide Enfuvirtide Levonorgestrel Levonorgestrel Levonorgestrel Levonorgestrel Levonorgestrel Epoetinalfa Epoetinalfa Thiopental Thiopental Thiopental Thiopental Nelfinavir Nelfinavir Nelfinavir Progesterone Progesterone L-Cystine L-Cystine Cinnarizine Cinnarizine Cinnarizine Cinnarizine Carmustine Carmustine Carmustine Tolazoline Tolazoline L-Isoleucine L-Isoleucine L-Isoleucine L-Isoleucine L-Cysteine L-Cysteine L-Cysteine Enflurane Enflurane Enflurane Enflurane Zileuton Zileuton Zileuton Zileuton Zileuton Amiloride Amiloride Amiloride Tenecteplase Tenecteplase Tenecteplase Imiquimod Imiquimod Imiquimod Fenfluramine Fenfluramine Tetracycline Tetracycline Tetracycline Ceftazidime Ceftazidime Ceftazidime Adenine Adenine Adenine Ardeparin Ardeparin Ardeparin Ardeparin Ardeparin Metaraminol Metaraminol Methysergide Methysergide Ibutilide Ibutilide Ibutilide Ibutilide Cladribine Cladribine Cladribine Troglitazone Troglitazone Troglitazone Troglitazone Phentolamine Phentolamine Phentolamine Tigecycline Tigecycline Tigecycline Tigecycline Betaxolol Betaxolol Betaxolol Betaxolol Atomoxetine Atomoxetine Atomoxetine Mefloquine Mefloquine Esmolol Esmolol Esmolol Esmolol Esmolol Estrone Estrone Epinastine Epinastine Epinastine Epinastine Epinastine Epinastine Bupivacaine Bupivacaine Bupivacaine Bupivacaine Bupivacaine Rosiglitazone Rosiglitazone Rosiglitazone Rosiglitazone L-Carnitine L-Carnitine Methylscopolamine Methylscopolamine Methylscopolamine Naftifine Naftifine Naftifine Naftifine Naftifine Rituximab Rituximab Rituximab Fluorometholone Fluorometholone Fluorometholone Fluorometholone Fluorometholone Fluorometholone NitricOxide NitricOxide NitricOxide Darifenacin Darifenacin Darifenacin Diltiazem Diltiazem Diltiazem Lenalidomide Lenalidomide Dexrazoxane Dexrazoxane Pirenzepine Pirenzepine Pirenzepine Testosterone Testosterone Alpha-1-proteinaseinhibitor Alpha-1-proteinaseinhibitor Flunisolide Flunisolide Flunisolide Hexachlorophene Hexachlorophene Hexachlorophene Hexachlorophene Hexachlorophene Sulfisoxazole Sulfisoxazole Sulfisoxazole Menadione Menadione Menadione Pyridostigmine Pyridostigmine Pyridostigmine Hydroxyzine Hydroxyzine Pamidronate Pamidronate Pamidronate Pamidronate Pamidronate Griseofulvin Betamethasone Betamethasone Betamethasone Inulin Inulin Mitotane Mitotane Ipratropiumbromide Ipratropiumbromide Ipratropiumbromide Succinicacid Succinicacid Nedocromil Nedocromil Nedocromil Ramipril Ramipril Ramipril Ramipril Ramipril Lovastatin Lovastatin Lovastatin Eplerenone Eplerenone Eplerenone Eplerenone Eplerenone Trovafloxacin Trovafloxacin Trovafloxacin Trovafloxacin Rasburicase Rasburicase Rasburicase PyridoxalPhosphate PyridoxalPhosphate PyridoxalPhosphate PyridoxalPhosphate Midodrine Midodrine Midodrine Midodrine Carisoprodol Carisoprodol Carbimazole Carbimazole Carbimazole ValproicAcid ValproicAcid ValproicAcid Reteplase Reteplase Reteplase Metyrosine Metyrosine Metyrosine Methylergonovine Methylergonovine Methylergonovine Arcitumomab Arcitumomab Arcitumomab Arcitumomab L-Tryptophan L-Tryptophan VitaminC VitaminC VitaminC Mazindol Mazindol Mazindol AminosalicylicAcid AminosalicylicAcid Amitriptyline Amitriptyline Beclomethasone Beclomethasone Meperidine Meperidine Meperidine Bleomycin Bleomycin Bleomycin Vasopressin Vasopressin Vasopressin Zolpidem Zolpidem Zolpidem Zolpidem Mometasone Mometasone Sildenafil Sildenafil Sildenafil Sildenafil Butorphanol Butorphanol Butorphanol Butorphanol Esomeprazole Esomeprazole Esomeprazole Cefotiam Cefotiam Cefotiam Doxylamine Doxylamine Sumatriptan Sumatriptan Sumatriptan Sumatriptan Sumatriptan Bortezomib Bortezomib Bortezomib Bortezomib Benzquinamide Benzquinamide Benzquinamide Timolol Timolol Timolol Timolol Fenoprofen Lamivudine Lamivudine Lamivudine Lamivudine Oxaliplatin Oxaliplatin Oxaliplatin Eletriptan Eletriptan Eletriptan Eletriptan Eletriptan Eletriptan Eletriptan Eletriptan Eletriptan Tobramycin Tobramycin Tobramycin Aldesleukin Aldesleukin Aldesleukin AntihemophilicFactor AntihemophilicFactor AntihemophilicFactor AntihemophilicFactor Oseltamivir Oseltamivir Modafinil Modafinil Modafinil Nitroprusside Nitroprusside Nitroprusside Nitroprusside Fluorescein Fluorescein Fluorescein Fluorescein Oxycodone Oxycodone Oxycodone Cyproheptadine Cyproheptadine NADH NADH NADH Spermine Spermine Spermine Phenytoin Phenytoin Lansoprazole Lansoprazole Lansoprazole Mephenytoin Mephenytoin Enalapril Enalapril Enalapril Enalapril Enalapril Enalapril Enalapril Raloxifene Raloxifene Raloxifene Natalizumab Natalizumab Natalizumab Natalizumab Amsacrine Amsacrine Amsacrine Basiliximab Basiliximab Basiliximab Basiliximab Basiliximab Basiliximab Basiliximab Basiliximab Basiliximab Basiliximab Fluoxetine Fluoxetine Fluoxetine Etonogestrel Etonogestrel Etonogestrel Etonogestrel Amodiaquine Atenolol Atenolol Atenolol Atenolol Atenolol Alfuzosin Alfuzosin Alfuzosin Alfuzosin Alfuzosin Pramipexole Pramipexole Pramipexole Pramipexole Icosapent Icosapent Icosapent Naltrexone Naltrexone Naltrexone Laronidase Laronidase Laronidase Laronidase Laronidase Laronidase Laronidase Sucralfate Sucralfate Zanamivir Zanamivir Zanamivir Dextrothyroxine Dextrothyroxine Dolasetron Dolasetron Dolasetron Imatinib Imatinib Imatinib Lisinopril Lisinopril Lisinopril Lisinopril Lisinopril Lisinopril Lisinopril L-GlutamicAcid L-GlutamicAcid L-GlutamicAcid Reboxetine Reboxetine Reboxetine Reboxetine Tamoxifen Tamoxifen Tamoxifen Interferonbeta-1a Interferonbeta-1a Interferonbeta-1a Protriptyline Meclizine Aminoglutethimide Aminoglutethimide Verteporfin Verteporfin Verteporfin Verteporfin Verteporfin Verteporfin Verteporfin Verteporfin Gonadorelin Gonadorelin Gonadorelin Gonadorelin Lorazepam Lorazepam Lorazepam Ibandronate Ibandronate Ibandronate Ibandronate Prilocaine Prilocaine Prilocaine Masoprocol Masoprocol Masoprocol Cyanocobalamin Cyanocobalamin Haloperidol Haloperidol Haloperidol Risperidone Risperidone Risperidone Streptokinase Streptokinase Ceruletide Ceruletide Foscarnet Foscarnet Foscarnet Oxcarbazepine Oxcarbazepine Oxcarbazepine Azithromycin Azithromycin Azithromycin L-Methionine L-Methionine Pyruvicacid Pyruvicacid Mupirocin Mupirocin Mupirocin L-AsparticAcid L-AsparticAcid L-AsparticAcid Dicloxacillin Dicloxacillin Chloroquine Chloroquine CoagulationFactorIX CoagulationFactorIX CoagulationFactorIX Furosemide Furosemide Furosemide Citalopram Citalopram Citalopram Clavulanate Clavulanate Clavulanate Atropine Atropine Atropine Fenoldopam Fenoldopam Fenoldopam Fenoldopam Fenoldopam Ritonavir Ritonavir Ritonavir Cyclosporine Cyclosporine Cyclosporine Cyclosporine Cyclosporine Interferonbeta-1b Interferonbeta-1b Interferonbeta-1b Monobenzone Monobenzone Monobenzone Ethoxzolamide Ethoxzolamide Ethoxzolamide Verapamil Verapamil Verapamil BenzylBenzoate BenzylBenzoate BenzylBenzoate BenzylBenzoate Tramadol Tramadol Tramadol Tramadol Tramadol L-Valine L-Valine L-Valine L-Valine Bexarotene Bexarotene Bexarotene Nimodipine Nimodipine Nimodipine Dofetilide Dofetilide Dofetilide Dofetilide Dofetilide Dofetilide Dofetilide Dofetilide Dofetilide Cevimeline Cevimeline Cevimeline Cevimeline Cevimeline Indomethacin Indomethacin Indomethacin Stavudine Stavudine Stavudine Altretamine Altretamine L-Lysine L-Lysine L-Lysine Denileukindiftitox Denileukindiftitox Denileukindiftitox Denileukindiftitox Benazepril Benazepril Benazepril Benazepril Benazepril Benazepril Moexipril Moexipril Moexipril Moexipril Moexipril Oxytocin Oxytocin CoagulationfactorVIIa CoagulationfactorVIIa CoagulationfactorVIIa Loratadine Loratadine Loratadine Loratadine Indinavir Indinavir Indinavir Chlorzoxazone Chlorzoxazone Chlorzoxazone Chlorzoxazone Bosentan Bosentan Bosentan Bosentan Bosentan Bosentan Bosentan Trimethoprim Trimethoprim Clotrimazole Clotrimazole Clotrimazole L-Threonine L-Threonine Olmesartan Olmesartan Olmesartan Olmesartan Olmesartan Olmesartan Olmesartan Olmesartan Olmesartan Olmesartan Olmesartan Olmesartan Olmesartan Olmesartan Acarbose Acarbose Acarbose Montelukast Montelukast Warfarin Warfarin Warfarin Anakinra Anakinra Anakinra Anakinra Interferongamma-1b Interferongamma-1b Interferongamma-1b Tirofiban Tirofiban Tirofiban Tirofiban N-Acetyl-D-glucosamine N-Acetyl-D-glucosamine N-Acetyl-D-glucosamine Fluphenazine Milrinone Milrinone Milrinone Milrinone Chlorambucil Chlorambucil Scopolamine Scopolamine Allopurinol Allopurinol Allopurinol Methoxamine Methoxamine Methoxamine Methoxamine Mebendazole Mebendazole Gemcitabine Gemcitabine Gemcitabine Gemcitabine Galantamine Galantamine Galantamine Dexmedetomidine Dexmedetomidine Dexmedetomidine Dexmedetomidine Dexmedetomidine Vidarabine Vidarabine Vidarabine Filgrastim Filgrastim Filgrastim Propranolol Propranolol Chlorthalidone Chlorthalidone Tenoxicam Tenoxicam Tenoxicam Tenoxicam Dipivefrin Dipivefrin Dipivefrin Oprelvekin Oprelvekin Oprelvekin Valaciclovir Valaciclovir Valaciclovir Valaciclovir Codeine Codeine Nitrofurazone Nitrofurazone Nitrofurazone L-Ornithine L-Ornithine Deferoxamine Deferoxamine Deferoxamine Dronabinol Dronabinol Riboflavin Riboflavin Riboflavin Riluzole Riluzole Riluzole Riluzole Marimastat Marimastat Xanthophyll Xanthophyll Xanthophyll Guanidine Guanidine Guanidine Icodextrin Icodextrin Icodextrin Grepafloxacin Grepafloxacin Grepafloxacin Carbachol Carbachol Carbachol Carbachol Rofecoxib Rofecoxib Rofecoxib Voriconazole Voriconazole Voriconazole Mirtazapine Mirtazapine Omalizumab Omalizumab Lercanidipine Lercanidipine Lercanidipine Lercanidipine Lercanidipine Brimonidine Brimonidine Brimonidine Brimonidine Brimonidine Alendronate Alendronate Alendronate Alendronate Dibucaine Alglucerase Alglucerase Alglucerase Piperacillin Piperacillin Piperacillin CarboprostTromethamine CarboprostTromethamine CarboprostTromethamine Dicumarol Nabumetone Nabumetone Nabumetone Carbamazepine Carbamazepine Pentamidine Pentamidine Pentamidine Aztreonam Aztreonam Sotalol Sotalol Sotalol Sotalol Sotalol Pentobarbital Pentobarbital Pentobarbital Torasemide Torasemide Torasemide Gadodiamide Gadodiamide Gadodiamide Gadodiamide Gadodiamide Gadodiamide Gadodiamide Gadodiamide Antithymocyteglobulin Antithymocyteglobulin Antithymocyteglobulin Antithymocyteglobulin Antithymocyteglobulin Antithymocyteglobulin Antithymocyteglobulin Midazolam Midazolam Midazolam Midazolam Lutropinalfa Lutropinalfa Lutropinalfa Lutropinalfa Hyaluronidase Hyaluronidase Cefmetazole Cefmetazole Cefmetazole Idoxuridine Idoxuridine Cefalotin Cefalotin Etomidate Etomidate Etomidate Tenofovir Tenofovir Tenofovir Pentazocine Pentazocine BotulinumToxinTypeB BotulinumToxinTypeB BotulinumToxinTypeB BotulinumToxinTypeB BotulinumToxinTypeB BotulinumToxinTypeB Vincristine Vincristine DornaseAlfa DornaseAlfa Cetuximab Cetuximab Cisplatin Cisplatin Cisplatin Flurazepam Ethosuximide Ethosuximide Fluvoxamine Fluvoxamine Vinblastine Vinblastine Vinblastine Chloramphenicol Chloramphenicol Cetirizine Cetirizine Cetirizine Cetirizine Cetirizine Propylthiouracil Propylthiouracil Hyoscyamine Hyoscyamine Trastuzumab Trastuzumab L-Phenylalanine L-Phenylalanine L-Phenylalanine Nisoldipine Nisoldipine Nisoldipine Nisoldipine Apomorphine Apomorphine Apomorphine Metformin Metformin Metformin Cetrorelix Cetrorelix Cetrorelix Metoprolol Metoprolol Metoprolol Desmopressin Desmopressin Desmopressin Phenelzine Sulpiride Sulpiride Sulpiride Argatroban Argatroban Argatroban Argatroban Argatroban Trihexyphenidyl Trihexyphenidyl Eszopiclone Eszopiclone Eszopiclone Eszopiclone Cimetidine Cimetidine Procyclidine Procyclidine Digoxin Digoxin Demeclocycline Demeclocycline Goserelin Goserelin Goserelin Morphine Morphine Morphine Becaplermin Becaplermin Becaplermin Becaplermin Oxytetracycline Oxytetracycline Clofibrate Clofibrate Bendroflumethiazide Bendroflumethiazide Sulfanilamide Sulfanilamide Phenindione Phenindione Fosinopril Fosinopril Fosinopril Fosinopril Fosinopril Fosinopril Cefdinir Cefdinir Cefdinir Carbenicillin L-Citrulline L-Citrulline L-Citrulline L-Citrulline Nitroglycerin Nitroglycerin Nitroglycerin Phosphatidylserine Phosphatidylserine AdefovirDipivoxil AdefovirDipivoxil AdefovirDipivoxil AdefovirDipivoxil Topiramate Topiramate Topiramate Sufentanil Sufentanil Sufentanil Sufentanil Tretinoin Tretinoin Tretinoin GallamineTriethiodide GallamineTriethiodide Alemtuzumab Alemtuzumab Alemtuzumab Alemtuzumab Alemtuzumab Daptomycin Daptomycin Daptomycin Flurbiprofen Flurbiprofen Flurbiprofen VitaminA VitaminA VitaminA Fluorouracil Fluorouracil Fluorouracil Nortriptyline Nortriptyline Ziprasidone Ziprasidone Ziprasidone Calcidiol Calcidiol Nicardipine Nicardipine Nicardipine Nicardipine Nicardipine Hydromorphone Hydromorphone Hydromorphone Tetrahydrofolicacid Tetrahydrofolicacid Atracurium Atracurium Atracurium Atracurium Palivizumab Palivizumab Olopatadine Olopatadine Olopatadine Olopatadine Olopatadine Moxifloxacin Moxifloxacin Moxifloxacin Moxifloxacin Moxifloxacin Toremifene Toremifene Toremifene Reserpine Reserpine Isoflurophate Isoflurophate S-Adenosylmethionine S-Adenosylmethionine S-Adenosylmethionine Furazolidone Furazolidone Furazolidone Megestrol Megestrol Megestrol Urokinase Urokinase Urokinase Etoposide Etoposide Etoposide Dextromethorphan Dextromethorphan Dextromethorphan Pentostatin Pentostatin Sulfasalazine Sulfasalazine Sulfasalazine Methocarbamol Methocarbamol Methocarbamol Trazodone Trazodone Terfenadine Terfenadine Terfenadine Terfenadine Valsartan Valsartan Valsartan Valsartan Valsartan Valsartan Valsartan Valsartan Valsartan Valsartan Valsartan Valsartan Valsartan Valsartan Valsartan Ticlopidine Ticlopidine Ticlopidine Ticlopidine Ticlopidine Lepirudin Lepirudin Lepirudin Aciclovir Aciclovir Aciclovir Doxazosin Doxazosin Doxazosin Doxazosin Doxazosin Alfentanil Alfentanil Alfentanil Alfentanil Adalimumab Adalimumab Adalimumab Nafcillin Pregabalin Pregabalin Pregabalin Pregabalin Mitomycin Mitomycin Mitomycin Mitomycin Framycetin Framycetin Teniposide Teniposide Teniposide Prazosin Prazosin Prazosin Prazosin Pantoprazole Pantoprazole Pantoprazole Pyrazinamide Pyrazinamide L-Histidine L-Histidine L-Histidine Olanzapine Olanzapine Olanzapine Vinorelbine Vinorelbine Vinorelbine Vinorelbine L-Arginine L-Arginine L-Arginine L-Arginine Doxycycline Doxycycline Doxycycline Peginterferonalfa-2a Peginterferonalfa-2a Peginterferonalfa-2a Clobazam Clobazam Clobazam VitaminE VitaminE VitaminE Secretin Secretin Secretin Nizatidine Nizatidine Chlorpromazine Liothyronine Liothyronine Ranolazine Ranolazine Ranolazine Ranolazine Ranolazine Anidulafungin Anidulafungin Anidulafungin Anidulafungin Tolmetin Tolmetin Tolmetin Triprolidine Triprolidine Triprolidine Triprolidine Infliximab Infliximab Infliximab Infliximab L-Asparagine L-Asparagine L-Asparagine gamma-Homolinolenicacid gamma-Homolinolenicacid gamma-Homolinolenicacid gamma-Homolinolenicacid Ethopropazine Ethopropazine Imipramine Imipramine Imipramine Pralidoxime Pralidoxime Moricizine Moricizine Prednisone Prednisone Prednisone Mannitol Mannitol Mannitol Thiethylperazine Thiethylperazine Propantheline Flutamide Flutamide Flutamide Linezolid Linezolid Linezolid Streptozocin Streptozocin Streptozocin Streptozocin Pyridoxal Pyridoxal Pyridoxal Glutathione Glutathione Glutathione Benztropine Choline Choline Choline Nystatin Nystatin Nystatin Erlotinib Erlotinib Candoxatril Candoxatril Candoxatril Candoxatril Candoxatril Candoxatril Bentiromide Bentiromide Bentiromide Bentiromide Cefotaxime Cefotaxime Porfimer Porfimer Porfimer Porfimer Porfimer Alprazolam Alprazolam Alprazolam Dyphylline Dyphylline Dyphylline Dyphylline Tripelennamine Tripelennamine Cidofovir Cidofovir Cidofovir Somatropinrecombinant Somatropinrecombinant Somatropinrecombinant Imiglucerase Imiglucerase Entacapone Entacapone Entacapone Entacapone Cycloserine Cycloserine Cephaloglycin Cephaloglycin Penciclovir Penciclovir Penciclovir Eptifibatide Eptifibatide Eptifibatide Eptifibatide Eptifibatide Diatrizoate Diatrizoate Diatrizoate Agalsidasebeta Agalsidasebeta Agalsidasebeta Agalsidasebeta Agalsidasebeta Agalsidasebeta Agalsidasebeta Agalsidasebeta Clodronate Clodronate Clodronate Clodronate Clozapine Clozapine Nicotine Nicotine Nicotine Pefloxacin Pefloxacin Pefloxacin Pefloxacin Methotrexate Methotrexate Methotrexate Triflupromazine Triflupromazine Triflupromazine Alitretinoin Alitretinoin Alitretinoin Oxandrolone Oxandrolone Daunorubicin Daunorubicin Loracarbef Loracarbef Loracarbef Loracarbef Trospium Trospium Trospium Valdecoxib Valdecoxib Valdecoxib Diethylcarbamazine Diethylcarbamazine Procaine Procaine Methylphenidate Methylphenidate Secobarbital Secobarbital Nilutamide Nilutamide Nilutamide Dydrogesterone Dydrogesterone Malathion Malathion Sorafenib Sorafenib Desogestrel Desogestrel Dihydroergotamine Dihydroergotamine Mexiletine Mexiletine Mexiletine Clemastine Clemastine Nitazoxanide Nitazoxanide Nitazoxanide AminocaproicAcid AminocaproicAcid AminocaproicAcid AminocaproicAcid Losartan Losartan Losartan Losartan Losartan Losartan Losartan Losartan Losartan Losartan Losartan Losartan Losartan Losartan Losartan Losartan Losartan Losartan Losartan Losartan AmphotericinB AmphotericinB AmphotericinB Zoledronate Zoledronate Zoledronate Cyclothiazide Cyclothiazide Cyclothiazide Nitrofurantoin Nitrofurantoin Alpha-LinolenicAcid Alpha-LinolenicAcid Alpha-LinolenicAcid Zafirlukast Zafirlukast AcetohydroxamicAcid AcetohydroxamicAcid AcetohydroxamicAcid AcetohydroxamicAcid Tositumomab Tositumomab Tositumomab Tositumomab Methadone Methadone Rocuronium Rocuronium Rocuronium Rocuronium Rocuronium Acamprosate Acamprosate Anistreplase Anistreplase Anistreplase Remikiren Remikiren Remikiren Remikiren Remikiren Remikiren Remikiren Remikiren Alteplase Alteplase Alteplase Mesalazine Mesalazine Mesalazine Muromonab Muromonab Muromonab Muromonab Muromonab Muromonab Celecoxib Celecoxib Celecoxib Celecoxib Ertapenem Ertapenem Ertapenem Ertapenem Gentamicin Gentamicin Gentamicin Gefitinib Gefitinib Ergocalciferol Ergocalciferol Minoxidil Minoxidil Minoxidil Minaprine Minaprine Minaprine Succimer Succimer Succimer Pravastatin Pravastatin Pravastatin Pravastatin Cefixime Cefixime Cefixime Perindopril Perindopril Perindopril Perindopril Perindopril Perindopril Bisoprolol Bisoprolol Bisoprolol Bisoprolol Metolazone Metolazone Paroxetine Paroxetine Leuprolide Leuprolide Leuprolide Creatine Creatine Creatine Creatine Piperazine Piperazine Piperazine Propoxyphene Propoxyphene Latanoprost Latanoprost Latanoprost Latanoprost Latanoprost Latanoprost Latanoprost L-Glutamine L-Glutamine L-Glutamine Fluconazole Fluconazole Fluconazole Darbepoetinalfa Darbepoetinalfa Temazepam Temazepam Remoxipride Remoxipride Remoxipride Sulindac Sulindac Guanabenz Guanabenz Guanabenz Guanabenz Carteolol Carteolol Carteolol Carteolol Carteolol InsulinLispro InsulinLispro InsulinLispro InsulinLispro InsulinLispro InsulinLispro Bevacizumab Bevacizumab Bevacizumab Bevacizumab Bevacizumab Bevacizumab Ergotamine Ergotamine Gadoteridol Gadoteridol Gadoteridol Gadoteridol Gadoteridol Gadoteridol Gadoteridol Gadoteridol Gadoteridol Gadoteridol Acitretin Acitretin Triamcinolone Triamcinolone Triamcinolone Triamcinolone Triamcinolone Niacin Niacin Hydroxocobalamin Hydroxocobalamin Pegvisomant Pegvisomant Pegvisomant Adinazolam Adinazolam Adinazolam Adinazolam GadobenateDimeglumine GadobenateDimeglumine GadobenateDimeglumine GadobenateDimeglumine GadobenateDimeglumine GadobenateDimeglumine GadobenateDimeglumine GadobenateDimeglumine GadobenateDimeglumine GadobenateDimeglumine GadobenateDimeglumine GadobenateDimeglumine Tranylcypromine Tranylcypromine Nevirapine Nevirapine Nevirapine Cisapride Cisapride Cisapride Cisapride Thioridazine Serumalbumin Serumalbumin Serumalbumin Serumalbumin Serumalbumin Serumalbumin Serumalbumin Serumalbumin Serumalbumin Raltitrexed Raltitrexed Raltitrexed Raltitrexed Enoxacin Enoxacin Enoxacin SodiumTetradecylSulfate SodiumTetradecylSulfate Vancomycin Vancomycin Vancomycin Buspirone Buspirone Buspirone Gadopentetatedimeglumine Gadopentetatedimeglumine Gadopentetatedimeglumine Gadopentetatedimeglumine Gadopentetatedimeglumine Gadopentetatedimeglumine Gadopentetatedimeglumine Gadopentetatedimeglumine Gadopentetatedimeglumine Tazarotene Tazarotene Norgestrel Norgestrel Pegfilgrastim Pegfilgrastim Pegfilgrastim Travoprost Travoprost Travoprost Travoprost Travoprost Travoprost Labetalol Labetalol Carbidopa Carbidopa Carbidopa Ampicillin Ampicillin Octreotide Octreotide Octreotide Piroxicam Piroxicam Piroxicam Disopyramide Disopyramide Mycophenolatemofetil Mycophenolatemofetil Mycophenolatemofetil Mycophenolatemofetil Mycophenolatemofetil Mycophenolatemofetil Mycophenolatemofetil Mycophenolatemofetil Erythromycin Erythromycin Tacrine Tacrine Tacrine Tacrine Alclometasone Alclometasone Alclometasone Alclometasone Alclometasone Thiabendazole Thiabendazole Thiabendazole Venlafaxine Venlafaxine Pentagastrin Pentagastrin Alprostadil Alprostadil Alprostadil Trandolapril Trandolapril Trandolapril Trandolapril Trandolapril Trandolapril Spironolactone Spironolactone Spironolactone Acetaminophen Acetaminophen Acetaminophen Pyridoxine Pyridoxine Methimazole Methimazole Methazolamide Methazolamide Lymecycline Lymecycline Glimepiride Glimepiride Glimepiride Glimepiride Prochlorperazine Prochlorperazine Prochlorperazine Treprostinil Treprostinil Treprostinil Treprostinil Capromab Capromab Capromab Fludrocortisone Fludrocortisone Tamsulosin Tamsulosin Tamsulosin Tamsulosin Tamsulosin Trimipramine Ropinirole Ropinirole Thiamine Thiamine Simvastatin Simvastatin Simvastatin Simvastatin Gadoversetamide Gadoversetamide Gadoversetamide Gadoversetamide Gadoversetamide Droperidol Droperidol Droperidol Ropivacaine Ropivacaine Ropivacaine Ropivacaine Ropivacaine Ropivacaine Lamotrigine Lamotrigine Lamotrigine Ibritumomab Ibritumomab Sermorelin Sermorelin Sermorelin Sermorelin Dicyclomine Glycine Glycine Glycine Aprepitant Aprepitant Famciclovir Famciclovir Famciclovir Astemizole Astemizole Astemizole Albendazole Albendazole Albendazole Aminohippurate Aminohippurate Aminohippurate Nicergoline Nicergoline Nicergoline Etodolac Etodolac Etodolac Etodolac Duloxetine Duloxetine Duloxetine Bacitracin Bacitracin Doxapram Doxapram Cephalexin Cephalexin Cephalexin Rifabutin Rifabutin Rifabutin Methohexital Methohexital Methohexital Methoxsalen Methoxsalen Anagrelide Anagrelide Menotropin Isoflurane Isoflurane Isoflurane Isoflurane Isoflurane Isoflurane Chlorotrianisene Chlorotrianisene Chlorotrianisene Chlorotrianisene Chlorotrianisene Triamterene Caspofungin Caspofungin Caspofungin Oxyphenonium Oxyphenonium Oxyphenonium Oxyphenonium Sulfametopyrazine Sulfametopyrazine Sulfametopyrazine Miglitol Miglitol Miglitol Miglitol InsulinGlargine InsulinGlargine InsulinGlargine Delavirdine Delavirdine Ketorolac Ketorolac Ketorolac Ketorolac Ketorolac Irinotecan Irinotecan Irinotecan Vindesine Vindesine Vindesine Clonidine Clonidine Clonidine Mecamylamine Mecamylamine Mecamylamine Mecamylamine Amikacin Amikacin Cabergoline Cabergoline Cabergoline Cabergoline Amlodipine Amlodipine Amlodipine Amlodipine Amlodipine Daclizumab Daclizumab Daclizumab Daclizumab Daclizumab Daclizumab Daclizumab Daclizumab Leucovorin Leucovorin Leucovorin Roxithromycin Roxithromycin Roxithromycin Candesartan Candesartan Candesartan Candesartan Candesartan Candesartan Candesartan Candesartan Candesartan Candesartan Candesartan Candesartan Candesartan Candesartan Candesartan Candesartan Candesartan Candesartan Candesartan Tolcapone Tolcapone Tolcapone Tolcapone Nateglinide Nateglinide Nateglinide Efalizumab Efalizumab Cerivastatin Cerivastatin Cerivastatin Cerivastatin Trimethadione Trimethadione Floxuridine Floxuridine Ciprofloxacin Ciprofloxacin Ciprofloxacin Cefmenoxime Cefmenoxime Pimecrolimu Pimecrolimu Isoetharine Isoetharine Isoetharine Gemtuzumabozogamicin Gemtuzumabozogamicin Gemtuzumabozogamicin Gemtuzumabozogamicin Amphetamine Amphetamine Tetrahydrobiopterin Tetrahydrobiopterin Tetrahydrobiopterin Ethambutol Ethambutol Isradipine Isradipine Isradipine Isradipine Clopidogrel Clopidogrel Clopidogrel Clopidogrel Clopidogrel Flucloxacillin Flucloxacillin Flucloxacillin Palifermin Palifermin Palifermin Palifermin Thioguanine Thioguanine Thioguanine Epirubicin Epirubicin Epirubicin Epirubicin Trifluridine Trifluridine Phentermine Phentermine Phentermine Diclofenac Diclofenac Diclofenac Diclofenac Meropenem Meropenem Meropenem Abciximab Abciximab Abciximab Abciximab Abciximab Abciximab L-Proline L-Proline L-Proline Bivalirudin Bivalirudin Bivalirudin Bivalirudin Bivalirudin Bivalirudin Medrysone Medrysone Lisuride Lisuride Colistin Colistin Nitisinone Nitisinone Nitisinone Zolmitriptan Zolmitriptan Zolmitriptan Zolmitriptan Zolmitriptan Zolmitriptan

Efavirenz Nelfinavir Cladribine Troglitazone Troglitazone Estrone Testosterone Menadione Menadione Amitriptyline Fenoprofen Fenoprofen Fenoprofen Oxaliplatin Oxycodone Cyproheptadine NADH Phenytoin Mephenytoin Mephenytoin Raloxifene Amodiaquine Naltrexone Tamoxifen Lorazepam Oxcarbazepine Tramadol Loratadine Indinavir Chlorzoxazone Warfarin N-Acetyl-D-glucosamine Dexmedetomidine Codeine Riluzole Grepafloxacin Grepafloxacin Rofecoxib Halazepam Halazepam Halazepam Halazepam Nabumetone Aztreonam Midazolam Ethosuximide Morphine Clofibrate Clofibrate Phenindione Topiramate Flurbiprofen Ziprasidone Hydromorphone Dextromethorphan Terfenadine Valsartan Pregabalin Liothyronine Imipramine Glutathione Tripelennamine Entacapone Entacapone Entacapone Entacapone Penciclovir Alitretinoin Alitretinoin Propoxyphene Fluconazole Temazepam Sulindac Acitretin Enoxacin Acetaminophen Methimazole Fludrocortisone Trimipramine Simvastatin Lamotrigine Lamotrigine Aminohippurate Nicergoline Etodolac Etodolac Rifabutin Ketorolac Irinotecan Irinotecan Irinotecan Irinotecan Tolcapone Tolcapone Tolcapone Cerivastatin Cerivastatin Epirubicin Diclofenac Diclofenac

Pharmaceutical drug transport: the issues and the implications that it is essentially carrier-mediated only

2011-07-09T22:41:00.000+01:00

Kell DB, Dobson PD, Oliver SG.

Drug Discovery Today. 2011

Go to article

Abstract

All cells necessarily contain tens, if not hundreds, of carriers for nutrients and intermediary metabolites, and the human genome codes for more than 1000 carriers of various kinds. Here, we illustrate using a typical literature example the widespread but erroneous nature of the assumption that the 'background' or 'passive' permeability to drugs occurs in the absence of carriers. Comparison of the rate of drug transport in natural versus artificial membranes shows discrepancies in absolute magnitudes of 100-fold or more, with the carrier-containing cells showing the greater permeability. Expression profiling data show exactly which carriers are expressed in which tissues. The recognition that drugs necessarily require carriers for uptake into cells provides many opportunities for improving the effectiveness of the drug discovery process.

Upcoming talk

2011-06-03T16:13:00.000+01:00

Well haven't I been quiet recently? I've been busy becoming a dad.

A crudely edited Routemaster, based upon an original image here.

Anyway, this is just a short advert for a conference I will be speaking at on the 23rd of June 2011 in London. It is called New Perspectives on Transporters in Drug Discovery and Development: ADME and Beyond and is organised by the Society for Medicines Research. Read all about it here.

My talk will be about the work I did in Manchester with Douglas Kell and Steve Oliver on drug transporters.

Getting it out in the Open

2011-03-17T23:19:00.003Z

"Bollocks to waiting 10 years for progress. I want people to know about it now, and then do something about it" - Dr Paul Fisher

UPDATE: Fisher didn't like the picture I used originally, so here's a better one.
I'm not taking the other one down though >>

Dr Paul Fisher ain't so happy

My friend and former colleague Paul Fisher has some workflows that link QTL (quantitative trait loci) data to pathway information in KEGG, with a bit of rudimentary text mining, to suggest which biochemical mechanisms underpin the trait. You can get a more complete description of the methods here, but my understanding of it is basically that QTLs are chromosomal regions known to be associated with a phenotypic trait. If Fisher finds that many genes in the QTL region map onto the same pathway, then that pathway might underpin the trait. So with the workflows we can move from a list of genes towards a mechanistic hypothesis.

Here the trait is Bilateral Perisylvian Polymicrogyria, a neurological condition in which the surface of the brain is irregular. Professor Wikipedia can tell you about it better than I, but then that's kind of the point of these workflows - they were developed for completely different traits but can easily be adapted.

So apart from it being the work of my friend, why have I focused on this? Fisher is a bioinformatician in a computer science department, not a clinician or an expert on BPP, who are the people who really need to see his results. Normal practice would be to publish them, most likely in a bioinformatics journal where the BPP experts probably won't see it, and this would all take far longer than necessary. So Fisher has decided to do away with that and just stick the data up on the Interweb straight away. Good for him.

It clearly is silly to slow down the release of valuable data by publishing everything in peer reviewed journals. The workflows are published and reviewed, and the data has been taken from the literature, so why not just get the new data from the workflows out as fast as possible? Oh yes, university politics again - research assessments and whatnot. Well I second Fisher's assertion - bollocks to it.

If we all thought more about the most appropriate way to disseminate our data then we'd surely conclude it's rarely wise to publish in slow, eye-wateringly expensive journals and being more open is the better choice. The king of all things Open Science is, of course, Cameron Neylon (if not the king then he is at least entitled to a very snazzy hat), who is always worth listening to. Following Fisher and Cameron, I have to work out how to get my data out there live and kicking, and have I got an Arduino-driven plan up my sleeve...

Fisher once made me go geocaching down a path in Cambridge. This is where you use your phone to look for some crap left somewhere by someone. It's a bit like dogging for people with no libido. After a good half hour rummaging in the bushes, I realised we were in fact poking around next to a nursery and this might have looked a bit dodgy. Perhaps some things shouldn't be done out in the open after all.

Mining metabolites: extracting the yeast metabolome from the literature

2010-12-18T23:57:00.000Z

Chikashi Nobata, Paul D. Dobson, Syed A. Iqbal, Pedro Mendes, Jun’ichi Tsujii, Douglas B. Kell and Sophia Ananiadou

Metabolomics. 2010

Go to article

Abstract

Text mining methods have added considerably to our capacity to extract biological knowledge from the literature. Recently the field of systems biology has begun to model and simulate metabolic networks, requiring knowledge of the set of molecules involved. While genomics and proteomics technologies are able to supply the macromolecular parts list, the metabolites are less easily assembled. Most metabolites are known and reported through the scientific literature, rather than through large-scale experimental surveys. Thus it is important to recover them from the literature.

Here we present a novel tool to automatically identify metabolite names in the literature, and associate structures where possible, to define the reported yeast metabolome. With ten-fold cross validation on a manually annotated corpus, our recognition tool generates an f-score of 78.49 (precision of 83.02) and demonstrates greater suitability in identifying metabolite names than other existing recognition tools for general chemical molecules.

The metabolite recognition tool has been applied to the literature covering an important model organism, the yeast Saccharomyces cerevisiae, to define its reported metabolome. By coupling to ChemSpider, a major chemical database, we have identified structures for much of the reported metabolome and, where structure identification fails, been able to suggest extensions to ChemSpider. Our manually annotated gold-standard data on 296 abstracts are available as supplementary materials. Metabolite names and, where appropriate, structures are also available as supplementary materials.

DIY Light Box

2010-12-15T17:35:00.000Z

In Sheffield we're interested in algae for producing biofuels. We sometimes grow them in conical flasks stood on light boxes, like the ones used in hospitals to look at x-rays. I was astonished at how expensive (and dim) they are. As ever, Instructables to the rescue! I flippin' love Instructables.

IKEA do a good line in plain, semi-transparent plastic tubs that diffuse light nicely. I balked at the price of their bright LED arrays, although perhaps the light would be less spiky than the fluorescent tubes I went for. We'll see. Here's what I used...

IKEA Snålis box lid (40 x 30cm) £0.60
IKEA Samla transparent box (39 x 28 x 14cm) £1.49
Wickes 275mm Under Cupboard Light £12.99
Aluminium foil (from my kitchen)

The Samla box doesn't go with the lid (but sort of fits) - I picked it because it is more shallow than the Snålis box. I lined it with foil, fitted a plug to the light and put it in. Because the lid doesn't quite fit you needn't even drill a hole in your nice box, although if things start getting a bit hot this might be a good idea along the sides.

The light is more uniform than it looks in the photo above, but more lights can be daisy-chained onto the same power supply if you need it to be brighter and widely spread. For £15 I'm quite pleased with it.

Now to save the planet

stoutbear - setting up a business as a postdoc

2010-12-01T10:13:00.000Z

This week I've launched the website for stoutbear - my small science business.

stoutbear is just a way for me to function as a sole trader to handle a small amount of consultancy work I'm doing. In the future it might grow to do other things.

I got some excellent startup advice from a free business adviser via University of Sheffield Enterprise (although my business is nothing to do with the University of Sheffield). The biggest difficulty was sorting out IP and contract problems with my main employer.

Here are some useful things I've discovered for postdocs thinking of setting up as consultants...

Research generates intellectual property but, by definition, consulting does not. Confine yourself to consulting and there should be no IP issues to resolve with your employer. Of course, there's a lot of semantic trickery hidden in there, so be careful.
Generally, postdoc contracts state that outside work only needs the approval of your line manager or head of department. Initially HR were rather obstructive in case it impinged on my university work (or perhaps they just wanted a quiet life), but fortunately my contract leaves that decision up to my HoD.
HR aren't the big, bad wolf. Go and see them (it's so much easier than using email), talk about what you want to do, and be reasonable - it is their job to make sure you do what you're paid for.
Having said that, you'd be surprised at how much officials are willing to turn a blind eye to.
For most postdoc consulting sole trader status is the ideal, lite-touch answer. This is basically a one-man band business structure, with debt risk taken by you. In my case there is no financial outlay, so no risk. It's pretty easy and cheap to set up.
I haven't got to this stage yet, but my business adviser assures me that tax self-assessment for sole traders is much easier than accountants make out.

Further developments towards a genome-scale metabolic model of yeast

2010-10-28T11:37:00.000+01:00

Paul D Dobson, Kieran Smallbone, Daniel Jameson, Evangelos Simeonidis, Karin Lanthaler, Pnar Pir, Chuan Lu, Neil Swainston, Warwick B Dunn, Paul Fisher, Duncan Hull, Marie Brown, Olusegun Oshota, Natalie J Stanford, Douglas B Kell, Ross D King, Stephen G Oliver, Robert D Stevens and Pedro Mendes

BMC Systems Biology. 2010;4:145

Go to article

Background

To date, several genome-scale network reconstructions have been used to describe the metabolism of the yeast Saccharomyces cerevisiae, each differing in scope and content. The recent community-driven reconstruction, while rigorously evidenced and well annotated, under-represented metabolite transport, lipid metabolism and other pathways, and was not amenable to constraint-based analyses because of lack of pathway connectivity.

Results

We have expanded the yeast network reconstruction to incorporate many new reactions from the literature and represented these in a well-annotated and standards-compliant manner. The new reconstruction comprises 1102 unique metabolic reactions involving 924 unique metabolites - significantly larger in scope than any previous reconstruction. The representation of lipid metabolism in particular has improved, with 234 out of 268 enzymes linked to lipid metabolism now present in at least one reaction. Connectivity is emphatically improved, with more than 90% of metabolites now reachable from the growth medium constituents. The present updates allow constraint-based analyses to be performed; viability predictions of single knockouts are comparable to results from in vivo experiments and to those of previous reconstructions.

Conclusions

We report the development of the most complete reconstruction of yeast metabolism to date that is based upon reliable literature evidence and richly annotated according to MIRIAM standards. The reconstruction is available in the Systems Biology Markup Language (SBML) and via a publicly accessible database (http://www.comp-sys-bio.org/yeastnet/).

On Meetings and Conferences

2010-10-27T14:08:00.000+01:00

"I think you might do something better with the time," Alice said, "than wasting it in asking riddles that have no answers."

A quote that often pops into my head in meetings and at conferences.

Alice in Wonderland, Lewis Carroll (1865)

Masters Courses - We are not amused

2010-10-06T01:30:00.000+01:00

Remember graduation day? Your Mum getting all emotional? Wearing a suit, a cloak and a stupid hat in the middle of summer? The photographer giving you a piece of PVC pipe to hold instead of your degree certificate?

Queen Victoria, who dished out many a university charter.

"I'm not happy" - that was her catchphrase.

Then what? For me it was a career in academic research - I never wanted to do anything else. I was fortunate, I found a PhD position without first doing a Masters. I've met a lot of Masters students, ranging from the clearly talented to the nearly useless. Not all of these people want a career in research, which is a good job because I wouldn't trust some of them to sit the right way on the toilet, never mind work in a laboratory. How do these people get on their courses?

I've been doing some snooping around to try to find out what the entry requirements are for different courses. About the only conclusion I can draw is that there are no universal standards. Some courses are extremely exacting, for others the main driver obviously is financial. And just look at the money involved (Table 1)!

University	Course	Home/EU Fees	International Fees
Manchester	MSc Analytical Chemistry	£16400	£16400
Manchester	MSc Computational Molecular Biology	£16400	£16400
Manchester	MRes Tissue Engineering for Regenerative Medicine	£3770 /£6100*	£14200/£16400*
Sheffield	MSc Stem Cell and Regenerative Medicine	£7710	£18630
Sheffield	MSc Life Science/Physical Science Integrated Studies	£3460	£14380
Sheffield	MSc(Eng) Environmental and Energy Engineering	£3460	£14380
UCL	MSc Drug Design	£7000	£19465
UCL	MSc Machine Learning	£4865	£18245
UCL	MSc Biomaterials and Tissue Engineering	£4865	£18245

Table 1. Example fees for full-time postgraduate taught courses. Data retrieved from: Manchester, Sheffield, UCL on 5^th October 2010. *Second figure is the fee including cost of consumables.

I'm not saying these particular courses are bad or over-priced, they are just examples to give an idea of how lucrative running a Masters course can be for a university. Yet I worry that when ability to pay is the main requirement this affects the quality of students taken on and teaching standards slip. Some courses (not meaning those above) are much too easy because they have to be to keep the pass rate up to attract students to make money. What a tawdry business.

Universities get away with this because their royal charter (or similar) typically asserts the right to confer degrees upon whoever they deem worthy without saying much about what constitutes worthiness. I agree with this freedom as any sort of national curriculum is unthinkable and unworkable. What I don't understand is the short-sightedness of abusing the charter for financial gain. If standards continue to slip people will notice that UK universities do not always produce good people, new people will stop coming and the money will dry up.

Worse still, the once proud UK university system will be left with its reputation in tatters. Queen Victoria, who conferred many of the university charters, would not be amused. Not that she ever was, the miserable old bat.

I'm not particularly interested in how things could be fixed (expect the usual, tedious, unimaginative cry of "more funding" from the universities), but in what a new graduate wanting to get into research should do. If a prospective PhD candidate came to me with an MSc of dubious worth most likely I would assume wealth, not talent (because I'm very sceptical). But if someone comes to me with their own papers published in a scientific journal, I'll be mightily impressed. I certainly wouldn't care that there is no royal charter behind them because Science has its own built-in metric for competence: peer review.

So let me "start a leveret" (figure 2) - graduates wanting to get into certain cheap areas of research, like bioinformatics, might better spend their money on their own research programme instead of on a dodgy Masters.

The problem with this is that research is a big step from a degree and postgraduate study is a kind of apprenticeship to facilitate this transition, but it needn't be the only way. I'll soon be set up as a consultant. I don't see how paying for a Masters is different to paying me to advise and collaborate with you, except I won't get involved unless I'm genuinely interested in the research and I will be compelled (by market forces) to offer a much better deal. Perhaps you might pay me to work with you for an hour or so a week (more if needed) until we publish something. I bet it would be cheaper and more worthwhile.

There'll be no degree, obviously, as I don't have a royal charter (and won't get one if I keep calling the Queen's great great granny an old bat), but instead the proof of the pudding will be in the publishing, and much more valuable it will be for it.

Figure 2. Starting a leveret. No, I don't understand what it means either.

If you were recruiting a new PhD student would you prefer to see a Masters certificate or a self-published, peer-reviewed scientific paper? Let me know through my poll (left).

I wish the world was more anarchic, in a gentle sort of way.

Rise of the Plastic Professors

2010-09-10T16:25:00.002+01:00

I found an interesting article from a few years ago on the Beeb the other day. Back in 2004 Professor Dame Nancy Rothwell, now President at Manchester, lamented the number of people being promoted to professor.

"I am worried about the potential decline in what being a professor means"

At that time an astonishing 9.7% of academics held the title of professor. Richard Wilson from Loughborough asserted that many promotions were nothing but rewards "for being instruments of the university's administration".

Yet the rising number of professors has a more tangible impact than simply devaluing the title. Professors earn a lot of money. In theory they bring in a lot too, but if these people are promoted due to longevity and not because they are good at what they do, of course this is unlikely to be the case. Actually all these plastic professors do is increase the average wage, not to mention probably demanding a bigger office, a PA, and that all the doors in the department be widened to fit their big heads through... it all costs money we don't have.

Owing to tenure it is hard to remove academics who don't perform, but here we are doing something worse - promoting them simply for not being sackably bad. It's not a promotion for good work, it's a promotion for not being atrocious or feeling up the students.

I need an incentive

Speak to professors about this and they come out with some bizarre nonsense, like the need for an incentive to get people to work. Is that enormous salary, freedom to pursue your research and a job for life not enough?

"I don't get out of bed in the morning for less than $10,000 a day"

Of course, if promotions were only given on merit most professors would still be way down the pecking order and the incentive would remain intact.

I am a martyr

The other nonsense some come out with is "if I went to industry they'd pay me more". For some professors this might be true, but not most. Good ones can demonstrate that industry wants them by working as a consultant - universities are keen on that these days - or consistently bringing in industry money. Then a professorship and a pay rise is fair enough. If a professor can't attract consultancy work, it's highly unlikely industry wants to pay them £100K a year.

Now I don't say that good professors should not be rewarded, but that, as Nancy Rothwell said...

"It should be an absolute judgment about internationally recognised research supported by international referees."

It's about time we called their bluff. If they will only work for more money, or believe (but cannot demonstrate) they'd have it better elsewhere, then they should be given a pat on the back and shown the door. There are thousands of extremely good researchers who would love the chance to replace them just as a regular, lowly lecturer*.

Otherwise these plastic professors should shut up, stop being so precious, and be thankful they aren't still stuck on the postdoctoral career rollercoaster, or worse, or much much worse.

*Which we could have more of for the same money.

Vince the Evil Genius?

2010-09-08T22:07:00.004+01:00

Oh Vince, what have you done? You seemed like such a nice, sensible chap.

Naughty Cable guy

It sounds like Vince Cable is going to take a rusty scythe to the science budget, leaving thousands of research scientists out in the cold, threatening our future economic security*, and doing untold damage to basic research capacity by favouring commercially-driven projects. A decent analysis of Vince's words comes from Evan Harris, here. Although the details aren't yet known, unsurprisingly the scientific community is up in arms.

My favourite suggestion from @arclight is that we scientists should use our technological skills to take the City hostage with some sort of Death Ray. Hmm, perhaps not. More practical is the suggestion that the scientific community puts on a show of strength by marching on London.

I'll let others go through the blindingly obvious reasons why science is so important to our economy that these cuts are bloody stupid idea. I also can't be bothered (because I've done it before) detailing why I believe Vince might have a point when he asks universities to do "more from less" - essentially I think many departments are flabby, wasteful pedlars of bollocks, FEC a farce, and the grant review system not fit for purpose. Cuts would be easier to resist if we hadn't been running such a rotten setup for so long.

Why have we ended up with such a crappy system for research? Pretty much all university research relies on grants from the government and charities. Success in this grant-awarding system is largely based upon... success in the grant-awarding system.

For he that hath, to him shall be given (Mark 4:25)

If you make it to the top within this system, naturally, you aren't likely to see a need for reform. But how can you know it is optimal? How unscientific. The grant system is a self-policed monopoly - how could it yield a lean, efficient system for research? I have little faith in reform by rules and regulations, what is needed is for the monopoly to be broken by a bit of competition. Now, I believe, is the ideal time for this.

There will be several thousand more scientists in the dole office over the coming years. That's terrible, but on the upside it is also a huge resource. Dave and Nick are big on Big Society, which (perversely) was best explained inadvertently by Tony Blair the other day when the BBC was helping promote his book tour...

"(serious face) you know, I believe, that, you know, the role of, government, (pensive face) is, to put in place, the systems, that, erm, you know, enable people, to help, themselves (inane grin)".

Well we scientists constitute a big society that needs a bit of help. The best result for everyone - scientists, the flabby university system, the economy, Big Bad Vince - would be to develop new ways to fund research without grants. This would generate that much-needed competition to sharpen up the universities, more jobs for us non-tenured** scientists, less demand on the remaining funding, and more research overall.

Perhaps Vince is an evil genius and this was his plan all along? Or perhaps Gorgeous Gideon put him up to it?

I've gone on about this idea of independent research many times before. With a bit of innovation it is possible for certain types of research. One good example is the Freshwater Biology Association in Windermere, who I'm told get by with very little grant funding. For a more underground flavour see the growing DIYbio movement. Getting something like this going is hard (I have tried), but perhaps Vince's words will make the threat that little bit clearer and focus our minds.

*As in other expensive northern European countries, leading research will likely be one of the few viable future economic activities for the UK.

**Tenure - another concept that must go.

Protein ROA Band Assignments

2010-08-31T00:05:00.004+01:00

When I was working with Ewan Blanch on protein Raman Optical Activity spectroscopy, one of the key problems was the lack of a central resource describing the band assignments (the signatures in the spectra that indicate the presence of a particular substructure). I did a bit of simple work towards bringing this together, but never really put it into action.

If you don't know what I'm talking about this probably isn't your cup of tea. It's things like the presence of a peak between X and Y indicates the presence of beta sheet, for example. If this information was all centralised it would be a lot easier to utilise and validate.

With this in mind, I've set up a little form to collate things. If you want to contribute do (but you probably won't). Two important points. 1) I'm only really interested in ROA bands (not Raman), and 2) I want to capture the provenance of the assignment, so at the very least I'd like a Traceable Author Statement.

UPDATE: you can see currently entered assignments (albeit in an unpretty form) here.

Don't bother spamming, it only takes about half a second to get rid of it.

Text Mining Paper

2010-08-19T16:31:00.000+01:00

I'm a paper machine this month! I have a second paper out, in collaboration with the National Centre for Text Mining (NaCTeM) and friends from Japan. You can find it here.

It's about linking a text mining-specific workflow system called U-Compare to the more generic Taverna workflow environment to make it easier to apply text mining methods to your textual data, whatever it may be.

Text Mining Meets Workflow: Linking U-Compare with Taverna

2010-08-19T16:16:00.000+01:00

Yoshinobu Kano, Paul Dobson, Mio Nakanishi, Jun’ichi Tsujii and Sophia Ananiadou

Bioinformatics. 2010;(Advance access)

Go to article

Abstract

Text mining from the biomedical literature is of increasingimportance, yet it is not easy for the bioinformatics communityto create and run text mining workflows due to the lack of accessibilityand interoperability of the text mining resources. The U-Comparesystem provides a wide range of bio text mining resources ina highly interoperable workflow environment where workflowscan very easily be created, executed, evaluated and visualizedwithout coding. We have linked U-Compare to Taverna, a genericworkflow system, to expose text mining functionality to thebioinformatics community.

Arabidopsis metabolic network

2010-08-16T13:43:00.000+01:00

We have a new paper out about the reconstruction of metabolic networks. Find it here.

Here I put my cheminformatics tools into action towards a new reconstruction for Arabidopsis thaliana, or mouse-ear cress, a popular model organism for plant biology and genetics.

Image source: Wikipedia

Integration of metabolic databases for the reconstruction of genome-scale metabolic networks

2010-08-16T13:30:00.001+01:00

Karin Radrich, Yoshimasa Tsuruoka, Paul Dobson, Albert Gevorgyan, Neil Swainston, Gino Baart and Jean-Marc Schwartz

BMC Systems Biology. 2010;4:114

Go to article

Abstract

Background
Genome-scale metabolic reconstructions have been recognised as a valuable tool for a variety of applications ranging from metabolic engineering to evolutionary studies. However, the reconstruction of such networks remains an arduous process requiring a high level of human intervention. This process is further complicated by occurrences of missing or conflicting information and the absence of common annotation standards between different data sources.

Results
In this article, we report a semi-automated methodology aimed at streamlining the process of metabolic network reconstruction by enabling the integration of different genome-wide databases of metabolic reactions. We present results obtained by applying this methodology to the metabolic network of the plant Arabidopsis thaliana. A systematic comparison of compounds and reactions between two genome-wide databases allowed us to obtain a high-quality core consensus reconstruction, which was validated for stoichiometric consistency. A lower level of consensus led to a larger reconstruction, which has a lower quality standard but provides a baseline for further manual curation.

Conclusion
This semi-automated methodology may be applied to other organisms and help to streamline the process of genome-scale network reconstruction in order to accelerate the transfer of such models to applications.

Every Inch the Gardener

2010-08-10T09:51:00.000+01:00

In the Sir Robert Hadfield building in Sheffield (where I now work) there is a green roof space - a sort of garden up in the air - designed by Dr Nigel Dunnett of the Green Roof Centre. I like the hidden surprise of roof and vertical gardens, and suspect they will become increasingly common.

Musée du quai Branly

View Larger Map

The Sir Robert Hadfield garden is one of a growing number of green roof spaces in Sheffield built to demonstrate their potential. They are so much more than parks in the sky to relax in, although this is justification enough. On a practical level green roofing also has a role in managing storm run-off as plants hold back water and slowly trickle it into the drainage system to prevent flooding.

In Paris there are a number of vertical gardens, where walls have been adapted to allow them to be planted (above). Just imagine how greatly this will change how our cities look and feel as it becomes more widespread. With walls of foliage replacing hard surfaces city sounds will become softer and gentler, while plants capable of trapping pollutants will improve air quality. With all the extra space I'm sure people will look to grow food, probably on a small scale initially, but later on will farms be multi-storey?

The shape of things to come? There were goats on the roof when I was there.

Old Country Market, Coombs BC, Canada

view on map

Walking around the Sir Robert Hadfield green space with it's handsome green oak and larch lodge, I thought some more about my dream lab - a shed for experiments and a garden to grow medicinal plants. I'm rather sceptical of herbal medicines as often they are nonsense and sometimes extremely dangerous, but I keep returning to the fact that many of our current medicines derive from plants and, contrary to what Dara O'Briain says, we haven't tested them all.

I can think of a number of relatively simple but useful experiments to investigate interactions between plant extracts and specific proteins that might lead to new drugs. The first step towards this is a well-stocked medicines garden, which I feel would be an interesting and fitting way to use the green space on a science department's roof. Perhaps I'll take my trowel to work.

Printing proteins: pdb to scad

2010-07-16T00:55:00.007+01:00

Getting a message from Cathal Garvey reminded me I haven't played with OpenSCAD for a while. OpenSCAD is a simple but powerful scripting language for making 3D models. I've been wondering for a while about converting PDB files into spacefill models of molecules in a format I could print them from, so I wrote a little Perl script to convert PDB to SCAD. Nothing clever.

This might look like a bear investigating a big flower, but it's actually aspirin rendered in OpenSCAD from this PDB file.

If you want the script it is here. Do whatever you like with it. Van der Waal's radii taken from here are expected in a local copy of this file. It should also work for proteins (which is why I chose PDB and not mol, sdf or whatever), but rendering so many atoms in OpenSCAD does tend to make things crash. I should probably try clean my PDB file up first by stripping out waters and so on.

I've no idea whether these would print or not, I can imagine all manner of problems that might arise. I'll try it some time, but if you get there before do let me know.

My new toy

2010-07-07T15:16:00.000+01:00

The nice people I soon will have once worked with bought me some really cool leaving presents, including a USB microscope! Hurrah.

Packing foam

Trousers

Condensation on a bottle

Ink splodge (dry wipe marker on plastic)

Infinity (image of image of image...)

The inside of Yogi's nose I shall spare you from.

Thank you

Manchester the Hippopotamus

2010-07-07T00:11:00.000+01:00

After first going to Manchester some time last century(!), it's finally time to leave. I'll be off to Sheffield soon to work with Cap'n Bilko on a new biofuels project. It isn't a totally new angle for me - much of the groundwork has been laid in Manchester through my work on modelling lipid metabolism. I'm hoping to do something applied and results-driven, not pie-in-the-sky/25 years until it works stuff. Not that there is anything wrong with basic research, just that we can't and needn't wait any longer for this project.

My time at Manchester was split between tiny, friendly UMIST, and big, cumbersome Manchester. This was quite some cultural change given that my desk never moved more than 150 yards when they merged in 2004.

Jackson's Mill on the old UMIST campus, where I did my PhD View Larger Map

Like the company that owned the vacuum cleaner factory in Stephen Poliakoff's Friends and Crocodiles, The University of Manchester is so big it's a bit like a hippopotamus - slow, lumbering and a bit difficult to steer, but at the same time pretty hard to bring down. It's size protects it, but it's not so nimble.

This much was evident during work with Douglas Kell on drug uptake transporters. Several times after presenting our work at conferences I have been approached by other Manchester researchers in our area that we had never met before, but clearly should have done. Communication is the single biggest problem with being a hippopotamus. There's no easy solution, but one simple thing might be to compel researchers to maintain a tag cloud of interests and expertise. It works for Flickr. Much better than paying useless facilitators that research staff openly resent.

Another problem I think size exacerbates is that to be noticed you have to make a lot of noise, and in my opinion some people put so much effort into this they end up not being very good at anything else, or they drown out better people who aren't so self-promoting. This happens everywhere I'm sure, but in the gargantuan melee that is Manchester I fear your voice has to be that little bit louder. It's okay, the hippo is hard to bring down, remember, but he'd be much happier without blood-sucking leeches.

Not that I want to give the impression Manchester is bad. It does many good things. Most recently the university has appointed Professor Dame Nancy Rothwell (DBE, FRS*) to President and Pro-VC. I may have once accidentally nearly knocked her down the stairs at a conference, and another time perhaps almost set her hair on fire (in the days when the Lass O'Gowrie still had gas lamps), but I didn't mean to. I worked briefly with one of the Rothwell group, David Brough (excellent scientist, well-deserved Fellow and thoroughly nice chap), who gave me the distinct impression Nancy Rothwell is some sort of superstar. I hope she knows how to handle a hippo.

*I went to the Royal Society to give a talk. The gallery of women fellows seemed to line a corridor that led only to the men's toilets. Hmm. (See 'The Admission of the First Women to the Royal Society of London')