Peter Attia

#395 – Brain lipidology: understanding APOE, cholesterol homeostasis, Alzheimer’s disease risk, and the effects of lipid-lowering therapies on brain health | Tom Dayspring, M.D.

Peter Attia — Mon, 08 Jun 2026 04:15:00 +0000

"Unfortunately, a prevalent belief out there in the real world is ‘I don't ever want to lower LDL cholesterol too much, because I'll deprive the brain and I'll injure the brain’ . . .and that is not true." —Tom Dayspring

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The beginning of the end of atherosclerosis?

Peter Attia — Sat, 06 Jun 2026 11:00:00 +0000

An early trial for a gene therapy that targets PCSK9 and profoundly lowers lipids

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#394 ‒ Sleep pharmacology: the role of medications in healthy sleep, the promise of emerging therapies, and the evidence for common sleep supplements

Peter Attia — Mon, 01 Jun 2026 04:15:00 +0000

“Different drugs vary in how quickly they work, how long they last, and which sleep problems they target. We need to match the medication's pharmacology to the patient's specific sleep challenges.” —Peter Attia

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Resistance training: lowering the barrier to entry

Peter Attia — Sat, 30 May 2026 11:00:00 +0000

Optimized programs with heavy weights are the gold standard for trained athletes. How much do they matter when starting fresh?

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Growth hormone for musculoskeletal system repair

Peter Attia — Tue, 26 May 2026 11:00:00 +0000

Despite the mechanism, growth hormone has not delivered on its promise for adult tissue repair

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#393 ‒ AMA #85: A guide to medications and supplements: determining what to take, what to skip, and how to know if they’re working for you

Peter Attia — Mon, 25 May 2026 04:15:00 +0000

“Poor problem definition almost guarantees some sort of false positive.” —Peter Attia

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What at-home HPV testing means for cervical cancer screening

Peter Attia — Sat, 23 May 2026 11:00:00 +0000

Pap smears transformed cervical cancer prevention. Now, self-collected HPV testing may help more women stay up to date on screening.

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#392 – Genetic testing: when it’s valuable, how to choose the right test, and what to do with the results

Peter Attia — Mon, 18 May 2026 04:15:00 +0000

“Like every tool we have in medicine, [genetic testing] has real strengths and real limitations, and its value depends almost entirely on how thoughtfully it is used.” —Peter Attia

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A critical look at ultra-processed diets and male reproductive health

Peter Attia — Sat, 16 May 2026 11:00:00 +0000

What a controlled feeding study in young men can—and cannot—tell us about ultra-processed foods.

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#391 ‒ Colorectal cancer screening: importance of early screening, colonoscopy as a screening and preventive tool, and how to build a personalized strategy

Peter Attia — Mon, 11 May 2026 04:15:00 +0000

“Most cancers are something that happen to you, but colorectal cancer is one of the few that you can intercept before it even exists.” —Peter Attia

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The dynamic physiology of the brain with menopause

Peter Attia — Sat, 09 May 2026 11:00:00 +0000

Menopause is often framed as a reproductive milestone. Brain imaging data suggest it may also be a neurological one.

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#390 ‒ AMA #84: Family health history, preventing heart disease, metabolic health, strength training efficiency, dementia risk reduction, NAD supplements, and hydration

Peter Attia — Mon, 04 May 2026 04:15:00 +0000

“There's a risk to doing anything, and then there's a risk to NOT doing something.” —Peter Attia

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Disappointing results from the first rapamycin-plus-exercise trial

Peter Attia — Sat, 02 May 2026 11:00:00 +0000

Why a single negative trial hasn’t diminished my interest in rapamycin as a potential geroprotector

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Reducing cardiovascular risk: a playbook for lipid-lowering pharmacotherapy

Peter Attia — Tue, 28 Apr 2026 11:00:00 +0000

Risk-stratified targets and a six-step playbook for choosing, combining, and escalating lipid-lowering therapy

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#389 – Thinking scientifically: why it’s hard, why it matters, and a practical toolkit

Peter Attia — Mon, 27 Apr 2026 04:15:00 +0000

“The goal of thinking scientifically is not simply to be right. It's to be less wrong over time. Science is a process built around that principle.” —Peter Attia

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There is no safe gamble with high LDL cholesterol

Peter Attia — Sat, 25 Apr 2026 11:00:00 +0000

The pitfalls of the lipid energy model and why “lean mass hyper-responders” should still take high LDL cholesterol seriously.

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#388 — Prostate cancer screening: why current PSA guidelines are failing men and how modern tools improve early detection and save lives

Peter Attia — Mon, 20 Apr 2026 04:15:00 +0000

“The timing of when you find the cancer is not a minor detail, it's arguably the determining factor in life and death.” —Peter Attia

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Prostate cancer: a PSA on PSA

Peter Attia — Sat, 18 Apr 2026 11:00:00 +0000

We have the tools to catch prostate cancer early—why aren’t we using them?

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#387 – AMA #83: Peptides—evaluating the science, safety, and hype in a rapidly growing field

Peter Attia — Mon, 13 Apr 2026 04:15:00 +0000

“The big picture is that peptides are a legitimate, powerful class of therapeutics, but the legitimacy is confined to a relatively narrow subset of them.” —Peter Attia

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Research Worth Sharing, April 2026 Edition

Peter Attia — Sat, 11 Apr 2026 11:00:00 +0000

Paternal exercise shaping offspring fitness via sperm microRNAs, mRNA COVID vaccines enhancing cancer immunotherapy, light-and-sound stimulation as a low-risk Alzheimer’s treatment, and autonomic nervous system imbalance as a unifying theory of aging

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#386 – Aging clocks—what they measure, how they work, and their clinical and real-world relevance

Peter Attia — Mon, 06 Apr 2026 04:15:00 +0000

"The biomarkers that capture aspects of the aging process could help us prioritize which ideas are worth testing more rigorously and putting more resources into.” —Peter Attia

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Updated cardiovascular guidelines—statin use in patients as young as 30

Peter Attia — Fri, 03 Apr 2026 11:00:00 +0000

Recommendations still may not be aggressive enough, but the needle is moving

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Thinking in trade-offs: a necessary antidote to diet tribalism

Peter Attia — Mon, 30 Mar 2026 18:00:00 +0000

Finding a diet that sustainably works for you is enough of a win. Why pretend it has no downsides?

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Protect the eyes, protect the brain—a potentially simple lever for dementia risk

Peter Attia — Sat, 28 Mar 2026 11:00:00 +0000

Uncorrected cataracts may do more than blur your vision. A recent meta-analysis explores what restoring sight could mean for long-term dementia risk.

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