pharma researcher

Anish Chandy, Preti k suresh, p H -Responsive and Mucoadherent Microparticles for Oral Delivery of Serratiopeptidase: Development and In Vitro Characterization, RJPBCS Volume 2 Issue 4 Page No. 662

2019-05-03T18:22:00.001-07:00

ISSN: 0975-8585
October – December 2011 RJPBCS Volume 2 Issue 4 Page No. 662
Research Journal of Pharmaceutical, Biological and Chemical
Sciences
p
H
-Responsive and Mucoadherent Microparticles for Oral Delivery of
Serratiopeptidase: Development and In Vitro Characterization
Preeti K Suresh1
* and Anish Chandy2
1 University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur (CG) INDIA
2 School of Pharmacy, Chouksey Engineering College, Bilaspur (CG) INDIA
ABSTRACT
The aim of the present study was to explore the potential of enteric coated chitosan microspheres as
carriers for oral site-specific delivery of peptides and proteins. In this study, microspheres of serratiopeptidase
were prepared by water in oil (w/o) emulsification solvent evaporation technique. Ratio of chitosan and
serratiopeptidase was varied in the range of 1:1, 1:2 and 2:1. The microspheres were then coated with Eudragit L
100. The product was obtained as non-aggregated free flowing microparticles. The drug content was found to be
between 15 to 40%. The presence of protein drug in the microparticles was confirmed by SDS-PAGE technique. In
vitro drug release studies indicated pH-responsive release profile. In vitro release of the drug first into phosphate
buffer pH 1.2 for 1 hr and then in phosphate buffer pH 6.8 at 37ºC was determined as a function of crosslinking
coating density of the microparticle. The pH-responsive behavior of the microparticle was confirmed, as there was
less than 10% release in phosphate buffer pH1.2. The extent of drug release had a remarkable dependence on the
coating density of the Eudragit L 100, the highly crosslinked spheres releasing only around 35% of the incorporated
drug in 6 hour compared to 40% from lightly coated spheres. The mucoadhesive nature of the microparticles was
established by an in situ method. These results indicate that Eudragit L 100 coated chitosan microparticles are
promising carriers for pH-responsive oral drug delivery of peptides and proteins.
Keywords: peptide, Eudragit L 100, Chitosan, pH-dependent, pH-sensitive, intestine-specific.
*Corresponding author
Email: preeti_venugopalan@yahoo.co.inINTRODUCTION
The intestinal drug targeting has been exploited for systemic delivery of active drugs. Most of the
peptide and protein drugs are unstable in the stomach and upper part of intestine. Apart from stability
problems, peptides are not well absorbed from the lumen of the GIT due to their large molecular size and
have high sensitivity to brush border peptidase activity. Comparatively, proteolytic activity of intestinal
mucosa is less than that observed in the stomach. Intestinal specific drug delivery systems protect peptide
drugs from hydrolysis and enzymatic degradation in the stomach, and eventually release drugs in the
jejunum, deuodenum, ileum or colon, which promises greater systemic bioavailability.
Serratiopeptidase (STP) is an anti-inflammatory, proteolytic enzyme isolated from the
microorganism, Serratia sp. HY-6 and is orally active [3]. Oral proteolytic enzymes have been
used successfully for inflammatory conditions. Recently, the intestinal absorption of orally
administered STP has also been demonstrated. To achieve an ideal therapeutic effect, however,
it is essential that any enzyme preparation be enterically coated so as to release the enzymes in
the intestines (where they can be absorbed) and not in the stomach (where they can be
digested). STP degrades in the stomach, but it is well absorbed from the small intestine.
Microsphere based drug delivery systems have received considerable attention in
recent years. The most important characteristic of microspheres is the microphase separation
morphology, which endows it with a controllable variability in degradation rate and drug
release.
pH-activated drug delivery systems permit the drug release at specific pH and the drug
molecules can thus be protected from degradation in the hostile gastric environment and in the
intestinal fluid the polymers dissolve and release the drug at intestinal pH>6.8. These types of
systems can be fabricated with polymers which are insoluble in acidic pH of stomach, but
soluble in basic pH prevailing in the intestine, viz., Eudragit L100, Eudragit S, Eudragit L, HMCP,
etc.
The aim of the present of work was to achieve site-specific controlled delivery of STP in
the small intestine. To achieve this objective Eudragit coated chitosan microparticles of STP were
prepared. The Eudragit coating will dissolve in the small intestine leaving chitosan microsphere,
which swells in the intestinal fluid leading to controlled release of STP from the microspheres.
The proposed mechanism is illustrated in Figure 1.
Fig. 1: Proposed mechanism of Eudragit®
coated chitosan microsphereshttp://www.rjpbcs.com/pdf/2011_2(4)/[70].pdf

ISSN: 0975-8585
October – December 2011 RJPBCS Volume 2 Issue 4 Page No. 664
MATERIAL AND METHODS
Materials
Chitosan (degree of deacetylation, 85.2%) particles with a viscosity 50 cps was obtained
as a gift sample from CFTI, Kochi, India. Serratiopeptidase was obtained from Centaur Labs Ltd,
Mumbai, India, as a gift sample. All other reagents used were of analytical grade from different
commercial manufacturers.
Development of Microparticles
Preparation of STP-containing chitosan microspheres (Chi-STP)
Chitosan (Chi) microspheres containing STP were prepared using w/o emulsification–
solvent evaporation method as reported by Hori et al [2]. Chitosan (100 mg) was dissolved in 5
ml of a 1% (v/v) acetic acid aqueous solution, and to this 2 ml of aqueous solution containing
STP (100 mg) was added. The chitosan (Chi) solution containing STP was dripped over 5 min into
200 ml of liquid paraffin containing SO-15
®
at 1% (w/v), which was continuously stirred at 500
rpm. The w/o emulsion obtained was stirred vigorously at 35C for 24 h, diethyl ether was
added, and the mixture was further, stirred overnight. The particles obtained were washed with
diethyl ether, 25% (w/w) ammonia aqueous solution, ethanol and diethyl ether in that order.
The particles were obtained by filtration and dried in air to yield microspheres.
ER-coated Chi-STP microspheres
Eudragit®
(ER)-coated Chi-STP microspheres (ER-Ch-STP) were prepared by coating Chi-
STP with Eudragit L 100 following the method reported by Bogataj et al [1]. Eudragit L 100 was
dissolved in 20 ml of acetone and the chitosan microspheres were dispersed in it. Then
equivalent amount of magnesium stearate was added and the dispersion was added dropwise
to 100 ml liquid paraffin (Heavy: Light = 1:1). To this dispersion 20 ml hexane was added with
stirring. The mixture was stirred for 90 min and the microspheres formed were collected by
filtration and washed with hexane twice and dried at room temperature.
Optimization of Process Variables
Various process variables, which could affect the preparation and properties of the
microspheres, were identified and studied. Preparation of pH-responsive microspheres involves
various process variables out of which drug: polymer ratio (D), temperature (T) and coating
polymer: microsphere ratio (P) was selected for the optimization of formulation.
The formulation code and respective variables used in the preparation of microspheres
are listed in Table 1. The effect of these variables was observed on particle size and size
distribution, % drug entrapment and % yield of microspheres.
CHARACTERIZATION
Size distribution and morphology
Scanning Electron Microscopy (SEM JEOL JSM-5800, Japan) was used to evaluate the
surface texture, shape and size of the microspheres. The samples for SEM were prepared by
lightly sprinkling the microspheres powder on a double adhesive tape, which stuck to an
aluminum stub. The stubs were then coated with gold to a thickness of about 300A using a
sputter container. The photomicrographs are shown in Figures 2 and 3.

Yield
To determine the % yield, weight of prepared microspheres was divided by the total
weight of all the non-volatile components used for the preparation of the microspheres. The
results are presented in Table 2.
Drug content
Chi-STP microspheres (10 mg) were dissolved in 10 ml of SIF (pH 7.4) by stirring with a
vortex mixer. An aliquot of 150 μl of the solution was treated with casein solution to detect itsproteolytic activity and to measure the amount of STP from the standard curve. The resultant
solution was centrifuged at 3000 rpm for 5 min and the supernatant was analyzed
spectrophotometrically at 280 nm.
Table 2: Encapsulation efficiency, yieldIn vitro release profile
Accurately weighed (60 mg) microspheres equivalent to 10 mg drug were suspended in
500 ml of mixed phosphate buffered saline (pH 6.8), and incubated at 37o
C and 90 rpm. After 1,
2, 3, 4, 5, 6 and 24 h incubation, 1ml of medium was collected, 4.5 ml Casein solution added
and allowed to stand for 37o
C for 20 min. [5] To the above solution, and trichloroacetic acid was
added to break the reaction. The supernatant collected and was used for the quantitative assay
of STP. For this assay, the final sample was obtained after centrifugation at 10,000 rpm for 5
min, and absorbance was measured spectrophotometrically at 280
ISSN: 0975-8585
October – December 2011 RJPBCS Volume 2 Issue 4 Page No. 668
ER-Chi-STP accurately weighed microspheres equivalent to 10mg drug were suspended
in 500 ml of phosphate buffered saline (pH 1.2) and incubated at 37o
C at 90 rpm. The samples
were collected at regular intervals of 15 min. The pH was then adjusted to pH 6.8. At 1, 2, 3, 4,
5, 6 and 24 h after the start of the incubation in mixed phosphate buffered saline (pH 6.8), 1ml
of the medium was taken, 4.5 ml casein solution was added and allowed to stand at 37o
C for 20
min. Trichloroacetic acid was added to this solution to break the reaction and then centrifuged
at 10000 rpm for 10 min. The supernatant was used for the measurement of the amount of STP
released. Proteolytic activity was determined to measure the concentration of STP by
spectrophotometric estimation at 280 nm. The results are presented in Figures 4-6.
Fig. 4: Drug release profile of various microparticles (drug: polymer ratio of 1:1)
Fig. 5: Drug release profile of various microparticles (drug: polymer ratio of 1:2)
Detection of Drug by SDS PAGE
10 mg microspheres were dissolved in 1ml phosphate buffered saline (pH 7.4), then
vortexed for 10 min, allowed to stand for 5 min and again vortexed for 5 min to obtain
equilibrium concentration of drug in solution. The sample was centrifuged at 10,000 rpm for 10
min. Supernatant was collected and used for SDS- PAGE. 20µl of supernatant was taken and
applied on gel with reducing buffer and dye methylene blue. The stain was detected by marker
silver stain. This procedure was repeated for non-reducing condition except using non-reducing
buffer in place of reducing buffer (Figure 7).
Fig. 7: SDS PAGE analysis of Serratiopeptidase in microspheres
ISSN: 0975-8585
October – December 2011 RJPBCS Volume 2 Issue 4 Page No. 670
Zeta potential
The microspheres were suspended in Phosphate buffer (pH 1.2) for 30 minutes. The
suspension (2% w/v) was employed for the determination of zeta potential. The results are
presented in Table 3.
Table 3: Zeta potential of selected microsphere formulations
Formulation Zeta potential (V)
A1
D2
Void Microspheres
+ 13.2
+ 8.5
+ 40.0
Mucoadhesivity
Mucoadhesivity was determined by an in situ method as described by [4]. A freshly cut
5-6 cm long piece of small intestine of rat was obtained and cleaned by washing with isotonic
saline. The piece was reversed with steel rod and the mucosal surface was exposed. Known
weights of microspheres were suspended in test tube containing phosphate buffer (pH 7.4) and
intestine section (exposed mucosal surface) was introduced into the suspension with a thread.
The intestinal piece was maintained at 80% relative humidity for 30 min in a desicator at 37C.
The piece was taken out and phosphate buffer pH 6.8 was allowed to flow over the intestinal
piece for about 2 minutes at a rate of 20 ml/min. The perfusate was collected and dried to
recover the unadhered particles. The % mucoadhesion was estimated by the ratio of amount
applied to adhered microspheres. The results are presented in Table 4.
Table 4: Percent mucoadhesion of various formulation of microspheres
Formulation % Mucoadhesion
A1
G2
D1
D2
36.95  3.66
40.13  0.10
19.16  5.85
31.66  1.66
Swelling properties
The water uptake by the non-crosslinked and crosslinked chitosan microspheres was
measured gravimetrically by swelling microspheres in deionized water (pH 6.0, 37°C) and
measuring changes in their weight during swelling. Microspheres were weighed and placed
inside a dialysis membrane, which was then introduced into the medium (50 ml) under
continuous stirring at 50 rpm and allowed to swell. The swollen samples were removed after
120 min and their surfaces were blotted with a filter paper to remove medium adsorbed on the
surface and then immediately weighed. Each swelling experiment was repeated twice and the
average value was taken as the degree of swelling, as calculated by:

ISSN: 0975-8585
October – December 2011 RJPBCS Volume 2 Issue 4 Page No. 671
S.W. = Mt-Mo / t
where, Mt denotes the weight of the swollen sample at time t and Mo is the initial
weight of the sample before swelling. The results are presented in Table 5.
Table 5: Degree of swelling of coated formulation
Formulation Degree of swelling
A1
A2
A3
E1
E2
E3
G1
G2
G3
0.76  0.04
0.86  0.04
0.80  0.02
0.78  0.04
0.72  0.06
0.78  0.04
0.80  0.03
0.78  0.02
0.66  0.06
X-Ray Powder Diffractometry
X-ray powder diffractometry (XRD) was carried out to investigate the effect of
microencapsulation process on crystallinity of the drug. Powder XRD patterns were recorded on
a powder XRD using Ni-filtered, CuKα radiation, a voltage of 30 Kv, and a current of 15 mA. The
scanning rate employed was 1° min-1
over the 20° to 60° diffraction angle (2θ) range. The XRD
patterns of polymers, drug and drug-loaded microspheres were recorded (Figure 8).
Microspheres were triturated to get fine powder before taking the scan.
Fig. 8: X-ray powder diffractometry of serratiopeptidase, polymer, chitosan and microparticles.

ISSN: 0975-8585
October – December 2011 RJPBCS Volume 2 Issue 4 Page No. 672
Statistical Analysis
Statistical significance of all the data generated was tested by analysis of variance
(ANOVA) followed by studentized range test. A confidence limit of P<0.05 was fixed for
interpretation of the results using the software PRISM (Graphpad, San Diego, CA).
RESULTS AND DISCUSSION
Some of the challenges of encapsulating proteins/enzymes for sustained delivery
namely high loading with high recovery, maintenance of enzyme integrity and sustained
delivery with a pH-responsive release have been successfully met with microspheres in this
study. It offers advantage for drug delivery of proteins/ enzymes, which can also be extended to
other therapeutic macromolecules.
Preparation of the microparticles
Chi-STP microspheres prepared by emulsification–solvent evaporation technique
showed good granulation. The particle shape was nearly spherical (Fig. 2). The mean particle
diameter was 8.3m. The mean STP content was between 13.7-31.2% (w/w), and the
encapsulation efficiency was more than 38%. ER-Chi-STP was prepared at different combination
ratios of Chi-STP to ER. The drug content was almost proportional to the ratio of Chi-STP.
Encapsulation efficiencies were 95.3–119.2%, indicating that the ideal drug content was well
achieved. Coated microspheres prepared by simple emulsification solvent evaporation method
with Chi-STP microspheres and Eudragit, showed a larger size, with the increase in amount of
Eudragit. The particle shape of A3, B3, etc. was irregular, but rugged ellipsoid.
Morphology of microspheres was examined by optical and s canning electron
microscopy. The view of the uncoated microspheres showed a hollow structure with a smooth
surface morphology whereas coated microspheres displayed a rough surface. The shell of the
uncoated microspheres showed some porous structures, which might have been caused by the
evaporation of solvent entrapped within the shell of microspheres after forming a smooth
dense skin layer. In contrast, the coated microspheres displayed continuous surface without
any porous structure.
The effect of the ratio of drug: polymer (Chitosan) in the aqueous phase on the
formation of the microspheres was evaluated keeping the volume of aqueous phase constant at
5 ml. The yield of the microspheres was found to be 85-98%. A variation in drug release was
observed, with highly loaded microspheres releasing more drugs. However, the average particle
size and the coating thickness increased as the amount of polymer were increased as reported
by Hori et al. [2]
The temperature of the dispersing medium was an important factor in the formation of
microspheres, because it controls the evaporation rate of the solvent. The microspheres
ISSN: 0975-8585
October – December 2011 RJPBCS Volume 2 Issue 4 Page No. 673
prepared at low temperatures (35C), had irregular morphology. At higher temperatures
(45C), the microspheres prepared had a darker brownish color and uniform shape. The
optimum temperature to form good microspheres was found to be 35 and 40C.
Emulsification–solvent evaporation technique gave Chi-STP microspheres, which had
pores adequate for release of STP. The coating with ER prevented Chi-STP from the dissolution
in SGF (pH 1.2). ER-coated Chi-STP microspheres released STP very slowly in mixed phosphate
buffered saline (pH 6.8), than Chi-STP. It was observed that high entrapment efficiency was
achieved at optimum drug: polymer ratio and optimum temperature.
In vitro drug release
Release of drug from pH responsive microspheres was evaluated at pH 1.2, and pH 6.8.
The initial slow release at the entire tested medium may be due to coating with Eudragit L100.
The uncoated microspheres of chitosan alone released a significant amount of drug through the
pores of the microspheres, as the polymer was soluble in acidic pH whereas the coating
prevented the release of drug. A combination of polymer was used for current study to design
pH responsive delivery system, which released most of the drug at lower gastrointestinal tract.
As the amount of Eudragit L 100 used in the preparation was increased, the release of the drug
decreased. The release in the mixed phosphate buffer (pH 6.8) may be due to the porous
nature of chitosan and Eudragit L100 and increase in the pores of the microspheres due to
swelling of chitosan. As the drug was most soluble in pH 6.8 and 7.4, its release was highest in
these mediums caused by diffusion through pores. The release of drug in the mixed phosphate
buffer (pH 6.8) was many times elevated than at pH 1.2. At pH 6.8, nearly 50% of the drug was
released as observed within first 6 hours. It may be due to swelling of chitosan in mixed
phosphate buffer.
In case of formulation A1 coated with Eudragit L 100, the maximum drug release was
seen in pH 6.8 and minimum at pH 1.2. There was an initial fast release of drug in pH 6.8, which
may be due to the dissolution of Eudragit L 100, in alkaline pH.
Formulation A3 prepared by coating with polymer at highest ratio to microsphere, also
showed the maximum drug release at pH 6.8. The effect of coating ratio of polymer to
microsphere on dissolution time was in the sequence as1:1<1:2<1:5, dissolution time.
X-ray powder diffraction study
The x-ray powder diffraction patterns of microspheres along with those of physical
mixtures and raw crystals of drug and polymer were studied. The Serratiopeptidase-Chitosan-
Eudragit system, in the form of microsphere, indicated the presence of the crystalline STP but
with a dramatic decrease of the intensity of the signal because of both a dilution effect and a
decrease in crystallinity of the drug. These results were in compliance with the reports of [6].
Detection of drug by SDS-PAGE technique
Formulation A and A1 was identified and tested for purity by SDS-PAGE technique. The
presence of drug in the microsphere was confirmed by this technique.
Bioadhesive study
The bioadhesion of microspheres was measured by the method reported by Rao and
Buri [4]. The adsorption of microsphere to mucin is expected to be dominated by the
electrostatic attraction between the positively charged chitosan and negatively charged mucin.
Therefore, the surface charges of microspheres represented by zeta potential influenced the
amount bioadhesed. The amount of microsphere adsorbed increased with increasing chitosan
concentration. Also, in conformity with the electrostatic attraction theory, the amount of the
adsorption decreased with decreasing zeta potential. Microspheres with highest zeta potential
are highly adsorbed. The mucoadhession of the microspheres increased with increase in net
concentration of chitosan.
The water uptake of microspheres prepared at 40ºC and 45ºC was more than those
prepared at 35ºC. It also increased with increase in chitosan content.
CONCLUSION
The drug carriers developed for oral peptide delivery in the present study have been
tailored to protect the sensitive macromolecular drug from the harsh environment of the
stomach and deliver biologically active peptide for an extended period of time to more favorable
regions for absorption along the GI tract. The results indicated pH-responsive release of
serratiopeptidase and also confirmed integrity of drug within the formulation. The integrity of the
drug could be maintained during the formulation process and other formulation objectives i.e.,
high encapsulation yield and loading combined with pH responsive release of drugs were also
achieved. Further, the method of preparation of microspheres adopted i.e. the emulsification
process, is amenable to easy industrial scale-up. These findings corroborate the idea that the
combination of pH-responsive and mucoadhesive properties can be utilized effectively to devise
strategies for oral delivery of peptidal drugs.
Declaration of Interest
The authors report no conflict of interests. The authors alone are responsible for the
content and writing of the paper.
REFERENCES
[1] Bogataj M, Burjak M, Velnar M, Grabnar I, Mrhar A. Int J Pharm 2001; 224: 123-30.
[2] Hori M, Onishi H, Machida Y. Int J Pharm 2005; 297: 223-34.
[3] Moriya N, Nakata M, Nakamura M, Takaoka M, Iwasa S, Kato K, Kakinuma A. Biotechnol
Appl Biochem 1994; 20: 101-8.
[4] Rao KVR, Buri P. Int J Pharm 1989; 52: 265-70.
[5] Ryden AN, Hofsten BV. Acta Chemica Scandinavica 1968; 22: 2803-8.
[6] Tayade PT, Kale RD. AAPS PharmSci 2004; 6(1): E12.

Data wastage due to slow internet

2016-06-02T23:46:00.001-07:00

Slow internet connection for a internet under is a barrier in surfing. It means more time to search a content in net.
More battery is used up, current stored in it is measured in milli ampere or mh.
Also cause heating of device which again cause a greater power loss.
It causes load on power grid.
Every 2 out of 5 people use internet randomly.
Its now part of life. E-commerce need are growing day by day.
A better battery support is what people need to surf for long duration.

Generally battery consumption on normal usage is 13 mh per minute
Only calls messages

Battery consumption rise on internet usage to get to 39 to 70 mh per minute

Slow internet like ,2 g or GPRS edge cause loss of current due to long term of use

2013-12-01T07:11:00.002-08:00

Ready to submit synopsis/ thesis

2013-12-01T07:06:00.000-08:00

Dear friends
A Grand oppertunity for you

Truely preparing synopsis, following university guidelines, checking correcting mistakes is a headache

ohh waste of time
]

lots of stress

and many other problem

Now Get rid of this problem

we have unique solution our experts will provide you the solution

SEND the title of your synopsis
SEND format of synopsis
SEND any data you wish to include and

GET a prepared complete copy of of well edited SYNOPSIS/ THESIS

only for few hundred bugs*

*contact directly at our browser.

now you have much time to your girlfriend, watch a movie and finally have a good impression on your guide

Novel herbal formulation

2013-04-16T22:06:00.003-07:00

Preparation and development of Novel Poly-herbal Formulation of .... drug withAntioxidant Activity.
Preparation and development of Novel Poly-herbal Formulation of .... drug with Immune Potentiating Activit.
Preparation and development of Novel Poly-herbal Formulation of .... drug with Hypoglycemic Activity.
Preparation and development of Novel Poly-herbal Formulation of .... drug with antiInflamatory Activity.
Preparation and development of Novel Poly-herbal Formulation of .... drug with Anticancer Activity.
Preparation and development of Novel Poly-herbal Formulation of .... drug with Cytotoxic Activity.
Preparation and development of Novel Poly-herbal Formulation of .... drug with Anti ucer Activity.

how to do reserch in pharmacology

2012-10-30T05:54:00.000-07:00

Pharmacological Research

Pharmacological Research provides a rapid information exchange medium for specialists within the discipline of pharmacology. The journal publishes papers on basic and applied pharmacological research and is proud of its rapid publication of accepted papers.
Invited and unsolicited review articles are also featured.
Research Areas are:
• Biochemical and molecular pharmacology
• Cardiovascular pharmacology
• Gastrointestinal pharmacology
• Clinical pharmacology, if addressing novel mechanisms of action
• Respiratory tract pharmacology
• Urogenital tract pharmacology
• Pharmacology of tissue repair
• Neuropharmacology, psychopharmacology, and neuroendocrinology
• Chemotherapy and cancer therapy
• Immunopharmacology
• Pharmacological applications of genomics
• Pharmacology of aging
• Nutraceuticals, if relevant to human disease
Note that ethnopharmacological studies generally do not fall into the scope of this journal. Exceptions are made for papers addressing the mechanisms of actions or the clinical applications of worldwide-used natural substances. Clinical studies on commercially-available nutraceuticals are also taken into consideration.
Immediate rejection criteria are:
1. Ethnopharmacological papers, namely studies that deal with locally-consumed plants.
2. In vitro antioxidant activity of plant extracts and pure compounds isolated from them.
3. Papers that describe pharmacological activities of plants which are not easily found worldwide, eg, Chinese herbs.
4. Papers reporting pharmacological activities of novel compounds if no proper controls with known substances are performed.
5. Papers describing the pharmacological activities of natural compounds are considered only if they identify novel mechanisms of action. In particular, Pharmacol Research does not publish papers that describe
• Single dose studies with very few animals, no dose-response studies.
• In-vitro assays with single dose or very high dose, measuring only one endpoint.
• Repetition of a simple bioassay for yet another extract or plant.

2012-10-26T01:37:00.001-07:00

hi friends

Topics you can work further

2012-09-28T19:31:00.000-07:00

Pharma acquisitions, mergers & joint ventures - Strategic Alliances
Telemedicine in India – e-healthcare only a click away
Developing Avenues for Collaborative Research Between Industry & Academia
Overview of national drug research institutes, Govt. drives and research funding
agencies in India
Electrophoretic technologies
Miniaturization & nanotechnologies
“Patent or Pass away”: Inescapable state for issue concerning academic drug
research
Solving the controversies in plant identification: The need of the hour
Bioremediation: An overview
Synthesis and biological evaluation of 2-thiosubstituted 1,3,4-oxadiazoles derivative.
Simultanious determination of Atorvastatin calcium, Enofibrate and Ezetimibe in pharmaceutical dosage form by HPLC method
Cardio-protective effect of Rutin considering cardiac injury marker in suprarenal aortic banding induced left ventricular hypertrophy
Cardio-protective Effect of Rutin Considering Anti-oxidative enzyme level and size of infarction in isoproterenol induced myocardial infarction
Greener way of synthesis: Phase transfer catalysis
Basic of LC-MS & its Application in Qualitative & Quantitative Analysis
Preparation and characterization of Sustained release Tramadol-HCL microsphere by spray-drying method
Biological evaluation and synthesis of 5-(pyridine-4-yl)-2-(Nsubstitutedcarboxamidoethylthio)-1,3,4-oxadiazoles by Schotten-Baumann reaction
Formulation and Evaluation of Floating Tablets of Captopril
Estimation of Sumatriptan Succinate in pharmaceutical dosage form by Liquid Chromatographic method
Determination Of Sumatriptan Succinate In Pharmaceutical Dosage Form By High Performance Thin Layer Chromatography Method
Antibacterial Action Of Prickly Pear Peel Extract
Synthesis and evaluation of antibacterial activity of 5-mercapto striazole derivative
Synthesis Of A Water-Soluble Derivative Of Anti-Fungal Agent With Advanced Inflammatory Activity
Preparation and characterization of agglomerates of Tolbutamide by Spherical crystallization technique
Microwave Assisted Synthesis of Heterocycles
Management Of Adverse Drug Reactions By An Innovative System
Investigation Into Therapeutic Role Of Peroxisome Proliferator Activated Receptor – γ Selective Agonist Pioglitazone In Asthma
Development and characterization of Cefdinir Nanosuspension for Enhancement of Oral Bioavailability
Design And Evaluation Of Gastroretentive Floating Drug Delivery System Of Ketoprofen
Gastro Retentive Drug Delivery System: A Review
Design And Development Of Orodispersible Tablets Of Diclofenac Sodium
2D-QSAR study on 1-acetyl-3-aryl-5-(4-methoxyphenyl)pyrazole analogous as an antifungal agents
Study of urinary biomarkers for nephrotoxicity in rats
Analytical Method Development & Validation for Estimation of Entacapone in Human Plasma
Lipid nanoparticles for improved topical application of drugs for skin diseases
Effect of abscisic acid on Fructose-Induced Insulin Resistance in rat
Study Of CNS Depressant, Sedative, Anxiolytic Effect And Skeletal Muscle Effect Of Methanolic Extract Of Hibiscus rosa-sinensis On Laboratory Animals
Investigation Into Analgesic And CNS Stimulant Activities of Seeds of Holarrhena antidysenterica In Laboratory Animals
Transdermal Permeation Enhancement by Herbal Terpenes

P1 - Investigation Into Immunomodulatory Activity Of Triticum aestivum
Evaluation of beads prepared with innovative techniques (Assembly)
Review: Pathophysiology & Current Treatment Of Alzheimer Disease
Synthesis & Antimicrobial Activity of Some Novel Carbazole Derivatives
Nanomedicine: Promising Tiny Machine For The Healthcare In Future
Analysis Of Food-borne Contaminants And Residues
Nasal Drug Delivery: Rapid Onset Via A Convenient Route
A Review: Osteoporosis And Its Treatment
A Review: Super Critical Fluid Technique
A Review: Pathophysiology And Current Treatment Of Thalassemia
A Review: Current Scenario And Treatment Of Asthma
Liposomes As Drug Delivery System: Promises And Challenges
Hepatoprotective activity of leaves of Rhododendron arboreum in CCl4 induced hepatotoxicity in rats
Transdermal Theraputic System of Atenolol: Effect of Hydrophilic and Hydrophobic Matrix on Ex Vivo Characteristics
A Review: Liver Toxicity Vs. Hepatoprotectives
Novel Method for Estimation of Marketed Formulation of Cefalexin by Colorimetric Method
Supercritical Fluid Technology-The Alternative Method for Extraction
Microsponge: A Novel Topical Drug Delivery System
Iontophoresis: Drug Delivery Using Safe Current
Carbon Nanotubes- A New Carrier for Targeted Drug Delivery System
Review on current therapies of cancer: Unveiling new horizons
Novel Analytical Method Development For Estimation Of Diclofenac Sodium By Using Co-Solvent By UV-Visible spectrophotometer
A Review: Epigenetic Drugs and Epigenetic Machinery
Resealed Erythrocytes
In-Vitro Comparative Evaluation Of Commercial Brands Of Tetracycline Hydrochloride Capsules
Development And Validation Of Colorimetric Method For Determination Of Pramipexole Hydrochloride Using Iron (III) And Ferricyanide
Sustained-Release Floating Microspheres Of Carbamazepine: Formulation, Optimization, Characterization And In-Vitro Evaluation
Formulation And Characterization Of Novel Taste Masked Mouth Dissloving Tablets Of
Tramadol By Sublimation Technique
Study on the Herb-Herb Interaction Potential of Glycyrrhiza glabra with Solanum xanthocarpum
and Adhatoda vasica, on neutrophil function
Formulation & Evaluation of Gastroretentive Drug Delivery System of Nifedipine
Improvement Of Dissolution Characteristics Of Meloxicam By Inclusion Complexation
With β-Cyclodextrin
Glycyrrhiza glabra exaggerates antiasthmatic activity of Adhatoda Vasica.
Determination of Linezolid In Bulk and In Pharmaceutical Dosage Forms by Visible Spectrophotometry

These topics are those which were having scope of modification and further new work can be done on them

How to face interview

2012-09-26T01:58:00.000-07:00

Steps to answer interview questions:

Step 1: Give a brief introduction about yourself:

For example: My name is Peter. I graduated from XYZ University with bachelor degree in Sales. After 5 years working as a Sales Manager, I have well experienced in training, mentoring and motivating other sales personnel to achieve the goals of the Company.

Step 2: Give a brief summary of your experience in your latest positions:

Give a summary of 2-3 latest companies that you have worked for and companies that have helped you succeed with your new jobs.

For example: recently, I have worked for ABC Company as Sales Manager for North-East Region. With my skills from training courses, I developed many sales campaigns which contributed much to the development of new customers and maintenance of current customer base. After 6 months, my sales force and I did regain the company’s market and promote the sales revenue up by 37%.

Step 3: Connect your ability to the employer’s requirements:
Never assume that the employer will by himself be able to connect all of your abilities to the job requirements.
Step 4: Make a concerning question:
With a concerning question, it will help you gain “control” of the interview. You may reduce the stress of the interview with such questions.
For example: I would like to know the strong points of your company’s current Sales force.

Some tips in answering:

1. Records/references: when giving information about yourself, remember to provide records/references as well;
2. Don’t make up the information: your information will be kept as records for a long time when you are employed. Also, the employer has many ways to checking whether your information provided are correct or not. Therefore, give the most faithful information as possible;
3. Practice: to answer well an interview question, you can practice with your friends or do it by yourself in a private room. Be sure that your answer is brief and within 3 minutes;
4. Keep information brief and relevant: Try making your answers more and more concise; Try to give much information in as short time as possible;
5. Eliminate irrelevant and unnecessary information.
Good Morning Sir/madam.

First of all I would like to thanks you to provide me a opportunity to introduce my self in front of you.

My name is Ashwini Kumar, I m from lucknow.

I have just completed my Graduation in B.Com stream from Faizabad University. And I did my intermediate in 2006 from Sadar lucknow.

In my family My father is an Army retired officer and my mother is homemaker. I have one elder brother and he is married.

In my experience I have worked as a trader in SDS Pvt ltd for 6 month & worked as a Forex trader for 1 year in Shri Forex Solution Pvt ltd. Right now I m working in Aegis BPO as a CCE but now I m a senior executive in K&E Dept.

My Hobbies are playing & watching cricket and listening music.

My short term goal is to catch this opportunity & get this job after that my long term goal is to get higher position in this company by applying my hard work & dedication towards my job.
A very good morning /evening everyone.

First of all thank you for giving me opportunity to introduce myself in front of you.

My name is Haider ali and am from panipat.

I have done my +2 from S. B. V. M school in panipat. And secured 72% marks.

Right now I'm in the fresher of BBA Bachelor of Business Administration from Piet collage. I done my schooling from panipat.

And coming to my family background, My family consist of 6 members my father is a business man. And my mother is a housewife. I have three elder sister.

My hobbies are Listening music, zymning Travelling to new places and exploring new people.

I have completed software and hardware course from hartron center.

My strength are I am a good listener as well as quick learner. I can work hard to achieve my goals in time.

My Weakness is that I will Feel Uncomfortable Until I Complete My Work within Time.

Thank you Sir for Giving Me This Opportunity!.
What do you know about this organization?
What do you know about our organization?
This question is one reason to do some research on the organization before the interview. Find out where they have been and where they are going. What are the current issues and who are the major players?

Sample answers:

1. A good organization with perfect management. I heard that in this organization i can gain knowledge and good atmosphere.
2. If its for a good renowned company then its better to go through the company website and know what’s the company profile and what’s their achievements/successes and branches & other details.
3. According to me this is one of the best company. It has a good Environment, We feel good working in companies, which has good growth in the IT Industries. This Organization has all the qualities like good growth, good Environment, maintaining a best level in the IT Industries, etc.
3. What are your career goals for Academic affairs?

The reasons of this question:

This question will test your ability and ambition to develop yourself as well as the ability to plan for the future.

2. Levels of career goals:

• You are not sure about your goals, then answer: I’m rather busy with my duties and goals of the Company; as a result, I haven’t focused much on my long-term personal goals.
• You have goals not or very little relating to the current job: For example, you are applying for a sales manager, but your career goal is to become the head of marketing department in the next 5 years.
• Current job oriented career goals: For example, you are working as a sales manager, you goal is to become the area sales manager in the next 2 years and in the next 5 years, you will be the regional sales manager.

4. What motivates you to do your best on the Academic affairs?

Answer tips

This is a personal trait that only you can say, but good examples are: Challenge, Achievement, Recognition
For any person motivation is the main factor which should make him work in an efficient manner.
And that motivation could be done my some rewards for doing good job, some encouragements etc. Moreover an employees good work must be acknowledged by his employer, which would definately boost him to work more harder to get more acknowledgements.

Answer samples

1. I was motivated both by the challenge of finishing the projects on time and by managing the teams that achieved our goals.
2. I want to be successful in my job, both for my own personal satisfaction and for my employer.
3. I’ve always felt that it’s important, both to me personally, and for the company and the clients, to provide a positive customer experience.
What experience do you have in this field? or Do you have any actual work experience?

Answer tips

• Speak about specifics that relate to the position you are applying for. If you do not have specific experience, get as close as you can.
• If you are being asked this question from your employer then you can explain your experience. Tell the employer what responsibilities you were performing during your job. You can tell what programs you developed and what modules you worked on. What were your achievements regarding different programs.

Answer sample

I have been working with computers since 2001 I also have a degree in network support/computer repair. I have built my last 3 computers, have work with Dell as an employee. So I have around 15 years experience working with computers.

5. How would you know you were successful on this Academic affairs?

Answer tips

Several ways are good measures: You set high standards for yourself and meet them. Your outcomes are a success. Your boss tell you that you are successful.
Answer sample
I m sure that I were successful in the because any job offered in your company is my dream and I can do any thing for my dreams. another way I am like to do this from my heart not for money.
so………

6. What is your greatest weakness?

1. Ways to answer:

a) First way: Turning your strong point into weak point.
For example: I am a perfectionist and therefore, I rarely believe in anyone who can work as well as me. As a result, I am afraid to delegate important tasks to others.
This approach has a weak side as that if you are not clever, you will cause the employer to believe that you are cheating him.
b) Second way: Solving your weakness absolutely.
A better approach is that you state one point which was once your weakness, but you have done well to resolve it.
For example: I tended to be a perfectionist, therefore I didn’t like to delegate to others. But I have found out that in order to develop the organization, everyone in the organization must be experienced with many tasks and this is very good for an efficient team work.

2. Steps to answer:

• You need to show it through your attitude and voice: It is really your weakness. And, you may also state some situations how much that weakness has caused you difficulties.
• Give your solution to resolve that weakness, partly or wholly.
• Solutions to a weakness may be training, mentoring, etc

love and thanks to dear friends

2012-09-09T05:33:00.000-07:00

thanks for getting upto the mark of double century hits by this month we are thankful to you all and need more suggestions on new topics which can improve the site view

We are curious to know about your views

Paid assistance in project "No Tension WORK"

2012-09-06T10:10:00.000-07:00

NO TENSION

TYYAR PROJECT

YAAR ISSE BADIYA AUR KYA

We can provide assistance to students of M.Pharm, B. Pharm and Pharm D who are interested in taking our service in further handling of their project or project related problems.
We have a group of knowledges teachers having specialization in various subjects and specialization from India and abroad.
We have Collaboration with established institutions in area of scientific research and analysis
We can Provide full ready to submitt thesis/ synopsis as per your requirement.
Partial work are also done on research work

Charges Depend on COURSE i.e., MinimumB.Pharm Rs2000, M.Pharm, RS15000, PharmD Rs15000
Further discussion by mail will help in some deductions or addition in charges depending on below mentioned points

EFFORTS and INSTRUMENTAL ANALYSIS REQUIRED
NO. Of Pages
STUDY PLAN AND EXPERT HELP
NO. OF HARD COPY+ ONE SOFT COPY REQUIRED
AUTHENTIC WORK FOR PUBLICATION IN RESEARCH PAPER

WE also provide service in providing ready to submitt/ Partial studied/ Instrumental help in MBA PROJECTS of various universities (MINIMUM Rs 5000 and above depending on study+hardcopy+soft copy)

We also provide ready to publish research or review articles in journals (MINIMUM Rs 2000 and above depending on study+soft copy)

We also assist in publishing articles in national and international journals (MINIMUM Rs 5000 and above depending on study+soft copy+journal+ individual + separate for additional charges authors)

We also can add your name within articles of our friendly authors in high impact journals so you can have help for yourself you has to do only is to contact and its yours

We have authors who publish books which can help you in having as an author yourself

Every transaction would be fair and additional bank transaction charges has to be bearded by customer

To prevent delay contact with full detail and specific about your work and university you belong.

BYE TO ALL AND BEST OF LUCK TO ALL

HOW TO CONVINCE YOUR GUIDE

2012-09-06T09:37:00.001-07:00

HOW TO CONVINCE YOUR GUIDE

I was going through discussion with few fellow readers of this blog and found that they are generally facing an problem of mis-conception, communication and lack of common understanding on an topic between a guide and an student

Dear friend its really a problem which generally all students feels or face or came through. Generally intelligent students easily can handle such situations. But truly all of us are not so cunning and intellegent, Its natural. So i thought to write about some tricks that can help you to came over such terrible condition.

1. Guide is the primary person who will judge your skill and decide that which project will be suitable to you and how can the project reach its destiny. It is very important to design a project as per his will it will not only help you to build a good relation but also help you to have some useful material with yourself and also a lot better marks than your classmates
2. Lack of communication is the basic reason: Generally guide expect his student to be in contact so that he can tell him his views to execute his veiwsor ideas into a study but most students try to avoid guide.

3. lack of understanding between guide and student: It is basically due to specialization of guide and interest of the student, guide wish from student to aquire new information in topic of his specialization and student dosent get through the idea
4. Some personnel problems of student or also in some case guide: Every human being is a human and humans have some social, nonsocial problems, which act as barrier in project activities.i.e. Back Exams, Family conditions, financial problems etc...Time boundation by guide, non liking of home visit by guide, etc
5. Grievance : It occurs due to some kind of bad response or any incidence which created in the mind of guide

Heyyy Friends Dont worryyyy here are the tips and reply me when ever you find it has helped you...

1. Contact your guide with even or uneven reasons atleast twice daily it will help you to get fimiliar with guide and his social activities also he find you as active and energetic student who is willing to do some good work.
2. Discuss Your personnel problem with guide it help your guide to know about you and understand your situation it will create some space for you in mind.
3. Remember to wish the guide at occasions and festivals because they wish that their student will be in contact with them although they not express this to you
4. Every guide likes to view his student as brilliant and an follower, of his ideas so try to know more about guide and accomplish guides achievements. Some time he may ask you to publish articles, attend seminar behalf of guide do it it will cost less but help you much at time of submission
5. Gifts are a good source or way of acquiring appreciation from guide even it is not much costly, some time its good to know guides hidden wish from you and fulfill as surprise.
6. Visit the guide at his/ her residence also boost relationship, its really a personnel touch...but it is not necessary that all will appreciate it so ask before a visit. Call your guide every time before a visit it will be convenient to you and guide and save time
7. Just always be confident to talk to your guide on a topic and always collect sufficent literature material before approaching guide dont think guide is a fool.
8. Try to provide your guide assistance in matters other than college, it will be tonic to those students who dont wish to work hard but wish to complete thesis with minimum effort
"ALLAH (GUIDE) Meharban To Gadha (Student) Pehelwan"
9. Most students fail to do this, at final submission of thesis get the signature of guide by gifting a new pen/ soft / hard copy of thesis its shows your goodwill and thanks to guide
This pen will work on MARKING
10. Listen to what Your guide is saying, behave manner-fully, try to complete assignment in time, put cool smile like fool it will refresh guide

BEST OF LUCK TO YOU ALL

CSVTU

2012-09-06T08:15:00.000-07:00

CONTENTS

Introduction .

1 Literature Review

Plant Profile

Pharmacological activity

Cuiltivation and collection

Scope of work

2. Preliminary phytochamical studies 1

2.1 physico chemical constant

Purification of solvent

2-3 Prepration of extract

2.4 Quantative phytochemical anylisis

3 Result and discussion

4 Conclusion

5. Reference

ACKNOWLEDGMENT

1 am thankful to the Almighty for blessings in successful completion of this
take this golden opportunity to express my heart felt gratitude and sincere ro my respected research guide ...................... ............ , lecturer of Pharmacy College, Raipur ...........constant invaluable guidance, constant encouragement and support which y .self-confidence and his patient association were of enormous help to me project work as a partial fulfillment ofB, Pharmacy, 1 am proud to say that it a most fruitful and enjoyable experience to work under his untiring guidance, I be to him for his constant support in ending and finalizing my

/ express my gratitude and sincere thanks to Head of department .........................

for providing facilities which enabled me to complete this work successfully,
! am also to ..................................................... for there

."t-r./us support throughout my -work.

It 's my pleasure to express my grateful thanks to Chairman and director Mr, * ..................................... College for the in and all other essential facilities given during project work,

I jm also thankful to , Librarians, and non teaching faculty of ................................. for theirs immense during literature survey,

not the least, 1 am very to my beloved sister who always preys and better future ami encourage me to give my hundred percent effort to project work.

B, Pharma Final Year

......................................

..........................(CG)

.............college, CSVT University,

Raipur Bhilai (C,G.)

CERTIFICATE

to certify that .................. S/O Shri .............. is a student of B. Pharma (Final Year) ................pharmacy College, Raipur done his Project Work satisfactorily.

He/she worked diligently,meticulously and methodically is authentic,

M, Pharm,

FORWARDING CERTIFICATE

This is to certify that MR. ......................................... S/O SHRI

............. is a student of B. Pharma, (Final Year) is .....................Pharmacy College Raipur has completed his on topic "TO ESTABLISH QUALITY CONTROL STUDY OF .................." under the guidance of Mr. .......................

He/she has worked very hard, delligently, carefully, systemically and collected literature very sincerely. The work performed by her/him is authentic. I recommended the project report to be respective examiners for evaluation

Dr. ................................
Head of department

topics hospital pharmacy: Review Reserch

2012-09-06T07:25:00.002-07:00

Pharmacy Education of Medical Undergraduates: Merit and demirShortcomings in medical education are a recognised factor in
prescribing errors. A previous study of MMUH doctors confirmed
there were omissions in medical undergraduate training with
respect to pharmaceutical issues such as prescribing and
medicines management.
Suggestions given in this study on how undergraduates' training in
could be improved, involving amendment of the undergraduate
curriculum to include pharmacist-mediated tutorials.
The Need for Needles Insulin pens are a patient-friendly manner to administer accurate
doses of insulin. They are available as pre-filled disposable units or
re-usable pens requiring cartridges of insulin.
An incident involving the inappropriate withdrawal of insulin from a
pre-filled insulin pen on a Medicine for the Elderly ward
The pharmacist as a member of a multidisciplinary group to control the use of restricted antibiotics
An evaluation of a pharmacist at a pre-admission clinic on the safety and accuracy of patients' medication on admission to the ward
EVALUATION OF THE COMPUTERIZED THERAPEUTIC PROCESS IN A HOSPITAL: PILOT STUDY
To studyInfusion reactions by systemic chemotherapy of anti cancer drugs
Self induced poisoning with hypoglycemic medication in non diabetic subjects
Results of pharmaceutical-care-programs in geriatric-populations
Analysis of medication errors in a psychiatric hospital
Drugs not included in the hospital formulary: Prescription error reduction with computerized prescription order entry Computerised Prescription Order Entry (CPOE) has been shown to
reduce prescription errors, mainly because of Clinical Decision Support
Medical prescripcion by drug name: analysis of factors influencing Prescription of medicines by international non-proprietary name (INN) instead of brand name improves quality and safety for the patient. It is recommended by the World Health Organisation. We aimed to increase generic prescribing by means of a printed prescription-administration sheet (PPAS) bearing the generic name,
which showed good results in a previous study.
drugs monitoring with laboratory test: a tool that improve the safety of the patient Pharmacological monitoring of hospitalised patients by means of blood tests is very important to decrease adverse drug reactions. This is not always easy to do as it is a lot of work daily for both
physicians and pharmacists.
Dosaging and Quality indicators of total parenteral nutrition for neonates or new born childs Adequate nutritional support for premature or sick neonates requires daily calculating and ordering of parenteral nutrition (PN). A standardized process for ordering, preparing, administering and
monitoring allows the team to calculate PN as well as to check recommended quality indicators.
Worlds First computerized medication error reporting system DokuPIK: establishment, results and clinical assessment. DokuPIK is the first German online database to report medication
errors and pharmaceutical interventions. In 2010, it was established as the standard reporting system in the Department of Orthopaedics at the St. Franziskus-Hospital, Münster. Six months after its establishment, clinical experience enabled a first assessment to be made of the system's relevance for future drug risk management.
Drug-related problems and pharmacist interventions in medical and surgical departments Hospital clinical pharmacists are crucial in drug therapy optimisation for detecting, solving and preventing drug-related problems (DRPs), which often translate to morbidity and mortality in hospitalised patients.
Optimization of treatment in patients with multiple sclerosis
Identification of drugs frequently associated with medication errors
Non-formulary prescriptions and hospital pharmacist's intervention in a Hospital Centre
Implementation of Quality Risk Management in the Clinical Pharmacy Field
Specific intervention in patients with therapeutic administration annual zoledronic to avoid duplication
Effect of a clinical pharmacist on drug therapy of patients in a long-term care facility
IMPLEMENTATION OF A SYSTEM OF DRUG SAFETY INFORMATION
Streamlining empirical antibiotic prescribing in paediatric intensive care
Introduction of an education, audit and feedback programme to improve the recording of clinical indication and duration on antimicrobial prescriptions.
drug history: medication reconciliations between patient's usual treatment and hospital prescription
Drug dosage adjustment in patients with renal impairment
Knowledge and usefulness of a drug alert-system for patients with kidney disease
Prevention on prescription medication errors: first quantification of pharmacist interventions
Non-small cell lung cancer therapy Detecting adverse drugs events with alarm signals in
a convalescence unit
Introduction of a comprehensive antimicrobial stewardship process to decrease broad spectrum
antimicrobial usage
Prevalence of potentially hazardous drug interactions
Analysis of the safety profile of drug in a group of patients with kidney/ liver disorder

image

2012-08-06T19:28:00.002-07:00

http://img407.imageshack.us/img407/3696/200762917494627996ai1.jpg

new fresh topics for project

2012-08-06T19:27:00.001-07:00

1,2,5-TRISUBSTITUTED BENZIMIDAZOLES AS POTENTIAL ANGIOTENSIN II RECEPTOR ANTAGONISTS
3D QSAR STUDIES ON A SERIES OF 6-[4-FLUORO-3-(PIPERAZIN-1-YLCARBONYL) BENZYL]-4,5-DIMETHYLPYRIDAZIN-3(2H)-ONES AS POTENT POLY(ADP-RIBOSE)POLYMERASE-1 (PARP-1) INHIBITORS ACTIVE IN BRCA DEFICIENT CELLS AGENTS. THE K-NEAREST NEIGHBOR MOLECULAR FIELD ANALYSIS APPROACH.
A REVIEW ON HPTLC FINGERPRINTING OF HERBAL DRUGS
A REVIEW ON ORAL NOVEL DRUG DELIVERY SYSTEM APPROCHES TO GESTERO RETENTION
A TYPICAL REVIEW ON DEVELOPMENT OF STABILITY-INDICATING ASSAY METHOD
A VALIDATED HPLC-UV METHOD FOR STANDARDIZATION OF SYZYGIUM CUMINI SEEDS AND RELATED ANTI-DIABETIC HERBAL FORMULATIONS
AN ALTERNATIVE MODE OF PROTECTION OF PHARMACEUTICAL ENTITIES
AN EMINENT APPROACH IN DRUG DELIVERY SYSTEMS: MICROEMULSIONS
AN UPDATED REVIEW ON THE DIFFERENT APPROACHES OF SOLUBILITY AND ORAL BIOAVAILABILITY ENHANCEMENT
ANALYTICAL METHOD VALIDATION PARAMETERS BY UPLC TECHNIQUE
ANJEER: A PHYTOPHARMACOLOGICAL REVIEW
ANTI-ANXIETY ACTIVITY OF PLANT BARK EXTRACTS: A POLYHERBAL FORMULATION
ANTIOXIDANT AND ANTIDIABETIC ACTIVITY OF POLYHERBAL FORMULATION ON STREPTOZOTOCIN INDUCED DIABETES IN EXPERIMENTAL ANIMALS
APPLICATION OF NANOTECHNOLOGY IN CANCER
APPROACHES FOR THE SYNTHESIS OF THIAZOLOPYRIMIDINE DERIVATIVES: A REVIEW
BENZTHIAZOLE DERIVATIVES AND THEIR BIOLOGICAL ACTIVITIES: AN OVERVIEW
BIODEGRADABLE MICROSPHERES FOR ORAL DELIVERY OF CALCIUM
BIOPHARMACEUTICS CLASSIFICATION SYSTEM: A BENCHMARK IN ORAL DRUG DELIVERY
BIOPHARMING: “AS A TOOL FOR DEVELOPMENT OF COST EFFECTIVE BIOLOGICALLY ACTIVE DRUG
CANCER P53- THE GUARDIAN ANGEL OF GENOME
CHALLENGES AND OPPORTUNITIES IN COMMUNITY PRACTICE
CHARACTERIZATION OF SOLID DISPERSIONS
CHEMOGENOMICS: A NOVEL INFORMATION TOOL FOR DRUG DISCOVERY
CHEWING: A PATIENT FRIENDLY DRUG DELIVERY SYSTEMS
CLINICAL STUDY OF HYPERTENSION DURING PREGNANCY
COLON SPECIFIC DRUG DELIVERY SYSTEM: NEW ERA OF DRUG DELIVERY
COMPARATIVE PHARMACOGNOSTIC STUDY ON ALBIZIA LEBBECK AND ALBIZIA PROCERA
CONTROLLED RELEASE VIA GASTRORETENTIVE SYSTEM: A REVIEW
CORDIA DICHOTOMA G. FORST AS A POTENTIAL MEDICINAL TREE: AN OVERVIEW
CURRENT STATUS IN ORAL DRUG DELIVERY SYSTEM (BUCCAL ROUTE)
DESIGN AND DEVELOPMENT OF FAST DISSOLVING PIROXICAM TABLETS BY SUBLIMATION TECHNIQUE: FOR THE EFFECTIVE TREATMENT OF DYSMENORRHEA
DESIGN AND DEVELOPMENT OF FLURBIPROFEN PHARMACOSOMES FOR ORAL DELIVERY: A REVIEW
DESIGN AND EVALUATION OF METRONIDAZOLE FLOATING TABLETS
DETERMINING THE EFFICACY AND TOLERABILITY OF ADVANCED GLYCATION END-PRODUCTS INHIBITOR ON INFLAMMATORY DISEASE ACTIVITY IN RHEUMATOID ARTHRITIS PATIENTS
DEVELOPMENT AND EVALUATION OF GASTRORETANTIVE FLOATING BEADS OF OFLOXACIN
DEVELOPMENT AND EVALUATION OF TOPICAL GEL OF MINOXIDIL
DEVELOPMENT AND STUDY OF ANTIMICROBIAL ACTIVITY OF SOME NOVEL IMIDAZO [2,1B]-1,3,4 THIADIAZOLE DERIVATIVES
DEVELOPMENT AND VALIDATION OF UV SPECTROPHOTOMETRIC METHOD FOR THE ESTIMATION OF LEVAMISOLE HCL
DEVELOPMENT OF ANTIMICROBIAL HERBAL GEL FORMULATION OF VITEX NEGUNDO LINN.
DEVELOPMENT OF BIOANALYTICAL LC−MS/MS METHOD - A CRITICAL REVIEW
DEVELOPMENT OF PROMETHAZINE THEOCLATE FAST DISSOLVING TABLETS USING CO-PROCESSING TECHNOLOGY
DEVELOPMENT OF UV SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF GLIPIZIDE IN PHARMACEUTICAL DOSAGE FORMS
DEVELOPMENT OF UV SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF SERRATIOPEPTIDASE IN PHARMACEUTICAL DOSAGE FORMS
DISODIUM EDETATE TOPICAL GEL: OPTIMIZATION BY CENTRAL COMPOSITE DESIGN AND EVALUATION FOR EXTERNAL RADIOACTIVE DECONTAMINATION
DISSOLUTION TESTING: LIFE LINE OF PHARMACEUTICAL FORMULATIONS
ENHANCEMENT OF SOLUBILITY AND DISSOLUTION OF GLIPIZIDE BY SOLID DISPERSION TECHNIQUE USING POLOXAMER 407
ESTIMATION OF FLURBIPROFEN BY UV- VISIBLE SPECTROPHOTOMETER
EVALUATION OF BASELLA ALBA L. LEAVES MUCILAGE AS AN INNOVATIVE SUSPENDING AGENT
EVALUATION OF TAMARIND SEED POLYSACCHARIDE AS A CARRIER FOR COLON SPECIFIC DRUG DELIVERY
EXCIPIENTS OF NATURAL ORIGIN IN DRUG DELIVERY SYSTEMS
FAST DISSOLVING FILMS: A NOVEL APPROACH TO ORAL DRUG DELIVERY
FAST DISSOLVING TABLET: A REVIEW
FAST DISSOLVING TABLET: AN OVERVIEW
FAST DISSOLVING TABLETS: AN OVERVIEW OF PREPARATION TECHNIQUES AND EVALUATION
FINGERPRINTING OF BOERHAAVIA DIFFUSA LINN. - A CRITICAL REVIEW
FLOATING DRUG DELIVERY SYSTEM: A NOVEL APPROACH IN CONTROLLED DRUG RELEASE
FLOATING DRUG DELIVERY SYSTEMS: AN APPROACH TO ORAL CONTROLLED DRUG DELIVERY VIA GASTRIC RETENTION
FLOATING TABLET- A NOVAL DRUG DELIVERY SYSTEM FOR CONTROLLED RELEASE OF DRUG
FORMULATION AND EVALUATION OF ACYCLOVIR TOPICAL GEL
FORMULATION AND EVALUATION OF COSMOCEUTICAL GEL BASED SHAMPOO USING MICONAZOLE NITRATE AS ANTIFUNGAL AGENT
FORMULATION AND EVALUATION OF DULOXETINE HYDROCHLORIDE DELAYED RELEASE CAPSULE ENTERIC COATING WITH HPMC P55
FORMULATION AND EVALUATION OF FAMOTIDINE CHEWABLE TABLETS
FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF TELMISARTAN
FORMULATION AND EVALUATION OF FLOATING TABLET OF ATENOLOL
FORMULATION AND EVALUATION OF FLOATING TABLETS OF METOPROLOL SUCCINATE
FORMULATION AND EVALUATION OF GASTRORETENTIVE MUCOADHESIVE MICROSPHERES OF RANITIDINE HCL USING CHITOSAN & GUAR GUM
FORMULATION AND EVALUATION OF MOUTH DISSOLVING TABLETS OF ATENOLOL
FORMULATION AND EVALUATION OF NIZATIDINE FLOATING TABLETS
FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLET OF PREGABLIN
FORMULATION AND IN-VITRO EVALUATION OF MELOXICAM GEL
FORMULATION DESIGN AND OPTIMIZATION OF MOUTH DISSOLVING TABLETS OF DOMPERIDONE USING SUBLIMATION TECHNIQUE
FORMULATION OF FAST DISINTEGRATING TABLETS BY DIRECT COMPRESSION:REVIEW
GASTRORETENTIVE FLOATING DRUG DELIVERY SYSTEM: AN APPROACH TO ORAL CONTROLLED DRUG DELIVERY VIA GASTRIC RETENTION.
GEMINI AMPHIPHILES: A NOVEL NON VIRAL GENE DELIVERY
HEPATOPROTECTIVE ACTIVITY OF MEDICINAL PLANTS – A REVIEW
HYDROGELS AS DRUG DELIEVERY SYSTEM
INNOVATION IN TRANSDERMAL DRUG DELIVERY
INTERACTION OF PROMETHAZINE WITH CYCLODEXTRINE
INTERPOLYMER COMPLEXED PATCHES FOR BUCCAL DELIVERY
INVOLVEMENT OF VARIOUS RECEPTOR SUBTYPES IN THE ANTIDEPRESSANT-LIKE EFFECT BY FORCED SWIMMING TEST PARADIGM IN RODENTS.
Isha Aggrawal FLOATING MICROSPHERES AS PROMISING GASTRORETENTIVE DRUG DELIVERY SYSTEM
LIPID BASED EMULSOMES FOR ORAL CONTROLLED DRUG DELIVERY
LIPID BASED SELF-MICROEMULSIFYING DRUG DELIVERY SYSTEM (SMEDDS) FOR LIPOPHILIC DRUGS: AN ACQUAINTED REVIEW
LIPOSOME AS VESICULAR DRUG CARRIER
LYCOPENE A NOVEL ANTICANCER COMPOUND
MELT GRANULATION TECHNIQUE: A PROMISING TECHNIQUE FOR ORAL DRUG DOSAGE FORM
MICROENCAPSULATION : A REVIEW
MICROSPHERES A REVIEW
MICROSPHERES –A REVIEW
MICROWAVE ASSISTED HIGH-SPEED CHEMISTRY: A NEW TECHNIQUE IN DRUG DISCOVERY
MICROWAVE INDUCED FUSION METHOD: AN EFFICIENT METHOD FOR THE PREPARATION OF SOLID DISPERSIONS
MULTIPARTICULATE ORAL SUSTAINED RELEASE DRUG DELIVERY SYSTEM
NANOMEDICINE AND ITS APPLICATIONS IN DRUG DELIVERY
NANOPARTICLUATE ORAL PEPTIDE DRUG DELIVERY
NANOSTRUCTURED MESOPOROUS SILICA MATRICES: A NOVEL TOOL IN NANOMEDICINE
NANOSUSPENSIONS AS AN ORAL CONTROLLED DRUG DELIVERY SYSTEMS FOR CLASS BCS II DRUGS
NEUROPROTECTIVE EFFECT OF METHANOL EXTRACT OF OCIMUM KILIMANDSCHARICUM GUERKE ON CEREBRAL ISCHEMIA AND REPERFUSION INDUCED CEREBRAL INJURY IN MICE
NEUROPROTECTIVE ROLE OF QUERCETIN AND PYRANOCARBOXYLIC ACID DERIVATIVES AGAINST ALUMINIUM CHLORIDE INDUCED ALZHEIMER’S DISEASE IN RATS
NEW TOOLS AND APPROACHES FOR MEASURING LIPOPHILICITY
NIOSOMES AS A DRUG DELIVERY SYSTEM : A REVIEW
NIOSOMES AS CARRIER
NIOSOMES AS CONTROLLED AND TARGETED DRUG DELIVERY SYSTEMS: SOME RECENT ADVANCES
NIOSOMES: NOVEL VESICLES AS A CARRIER SYSTEM
NITROGLYCERINE TRANSDERMAL PATCH, A NOVEL APPROACH
NOVEL DRUG DELIVERY SYSTEM IN HERBAL DRUGS
NOVEL HYDROGELS AND THEIR DRUG DELIVERY STRATEGIES: A REVIEW
ORAL CONTROLLED DRUG DELIVERY OF ESOMEPRAZOLE MAGNESIUM TRIHYDRATE VIA GASTRORETENTION
ORAL CONTROLLED DRUG DELIVERY SYSTEM: AN OVERVIEW
ORYZA SATIVA LINN. AS A SOURCE OF ANTIOXIDANT AGENTS
PELLETS – A UNIVERSAL FORMULATION FOR ORAL DRUG DELIVERY
PHARMACOGNOSTIC AND PHYTOCHEMICAL PROPERTIES OF FICUS ARNOTTIANA MIQ – AN OVERVIEW
PHARMACOGNOSTIC COMPARISON OF AZADIRACHTA INDICA AND MELIA AZEDARACH LINN. LEAVES
PHARMACOGNOSTIC EVALUATION AND ANTIMICROBIAL ACTIVITY STUDIES ON GENTIANA OLIVIERI GRISEB
PHARMACOGNOSTICAL AND MICROBIOLOGICAL STUDY OF INDIGOFERA CORDIFOLIA
PHARMACOGNOSTICAL AND PHYTOCHEMICAL INVESTIGATION OF ZALEYA GOVINDIA
PHARMACOLOGICAL INTERVENTIONS OF VITEX NEGUNDO LINN.- A REVIEW
PHYTOCHEMICAL AND ANTIBACTERIAL STUDIES ON THE LEAVES OF QUISQUALIS INDICA
PHYTOSOMES: A NOVEL DRUG DELEVIRY SYSTEM FOR IMPROVING BIOAVAILABILITY
PREPARATION AND EVALUATION OF PHENYLEPHRINE HYDROCHLORIDE LOADED CHITOSAN NANOPARTICLES FOR IMPROVING ITS ORAL ABSORPTION
PULSATILE DRUG DELIVERY SYSTEM
PULSATILE DRUG DELIVERY SYSTEM: AN NOVEL MOVE IN CHRONOTHERAPEUTICS
RECENT ADVANCES IN THE FORMULATION OF MDDDS
RECENT TECHNOLOGICAL ADVANCES IN ORAL DRUG DELIVERY.
REDUCING THE USE OF LABORATORY ANIMALS IN RESEARCH BY IMPROVING EXPERIMENTAL DESIGN AND STATISTICS
REVIEW ON : FAST DISSOLVING TABLET
REVIEW ON ENTERIC COATED POLYMERS, FORMULATION, DEVELOPMENT AND EVALUATION TECHNIQUES
REVIEW ON FLOATING DRUG DELIVERY SYSTEM: AN EMERGING CONCEPT
ROSEMARY: A PHYTOPHARMACOLOGICAL REVIEW
SELF MICROEMULSIFYING DRUG DELIVERY SYSTEM FOR BIOAVAILABILITY ENHANCEMENT: AN OVERVIEW
SHILAJIT: AN ENERGENIC MEDICINE
STANDARDIZATION AND EVALUATION OF ANALGESIC ACTIVITY OF PICRORHIZA KURROOA ROYLE EX BENTH RHIZOMES
STOMACH SPECIFIC MUCOADHESIVE MICROSPHERES AS CONTROLLED DRUG DELIVERY SYSTEM-A REVIEW WORK
STOMACH SPECIFIC MUCOADHESIVE-A REVIEW
STOMACH TARGETED DRUG DELIVERY SYSTEMS: ADVENTS PROSPECTIVES
STOMACH TARGETED DRUG DELIVERY SYSTEMS: FUTURE PROSPECTIVES
SUPERCRITICAL FLUID TECHNOLOGY: NOVEL APPROACH FOR THE PREPARATION OF SOLID DISPERSION
SYNTHESIS AND EVALUATION OF 1,3,4-OXADIAZOLE DERIVATIVE AS ANTI-LEISHMANIAL AGENTS
SYNTHESIS AND EVALUATION OF NEWER 1,3,4-THIADIAZOLE DERIVATIVES
SYNTHESIS AND EVALUATION OF SOME NEWER INDOLE DERIVATIVES
SYNTHESIS AND EVALUATION OF SOME NOVEL 5-SUBSTITUTED CYCLOPROPYLIMIDAZO [2,1-B][1,3,4] THIADIAZOLE DERIVATIVES
SYNTHESIS, CHARACTERIZATION AND EVALUATION OF NOVEL1,3,4-OXADIAZOLE DERIVATIVES
TABLET: - A REVIEW
TASTE MASKING TECHNOLOGIES: - WAY TO OVERCOME THE BITTER TASTE OF DRUGS
TERPENES AS PENETRATION ENHANCERS IN TRANSDERMAL DELIVERY SYSTEM
THERMOREVERSIBLE MUCOADHESIVE GELS FOR NASAL DRUG DELIVERY: A REVIEW
TIMERx TECHNOLOGY
TO STUDY ANTIPYRETIC AND ANTIDIARRHOEAL ACTIVITIES ON WHOLE PLANT OF “FAGONIA SCHWEINFURTHII HADIDI”
TOPICAL GEL FORMULATION –A REVIEW
TRANSDERMAL PATCHES: A DISCRETE DOSAGE FORM
TRANSFEROSOMES A NOVEL APPROACH FOR TRANSDERMAL DRUG DELIVERY SYSTEM
TRANSFEROSOMES:- AS VESICULAR CARRIER SYSTEM
VALIDATED RP-HPLC METHOD DEVELOPMENT FOR THE ESTIMATION OF BORTEZOMIB IN PARENTERAL DOSAGE FORM.
VARIOUS APPROACHES FOR SYNTHESIS OF PYRAZOLINE DERIVATIVES: AN OVERVIEW
VESICULAR SYSTEM AS A CARRIER

new topics

2012-08-05T07:36:00.003-07:00

Brand vs. Store Brand Acetaminophen Stomach Dissolving Rate
Dissolution Rate of Lactase Pills
Which Antacid Can Neutralize The Most Stomach Acid?
A NOTE ON THE EFFECT OF NICOTINE INJECTION ON ADRENAL SECRETION
A STUDY OF THE ACTION OF VARIOUS DIURETICS IN NEPHRITIS

2012-07-31T02:40:00.003-07:00

Completion and validation of a Graduation Research Project is an essential requirement for obtaining the degree of B. Pharm. The Project is required to be prepared as per the following rules and conditions:

The students in the fourth year of B. Pharm. shall present a project based on all round knowledge they have acquired in the five main subjects viz., pharmacy practice, pharmaceutics & pharmaceutical technology, pharmaceutical & medicinal chemistry, pharmacognosy, & phytochemistry and pharmacology & toxicology. This project also includes a research work, which the students carry out on recent developments in pharmaceutical sciences.

Objectives of the Graduation Research Project

To ensure that the sum total of the academic achievement of the student is in consonance with the goals of the College.
To ensure that the student is sufficiently trained to extract necessary pharmaceutical information directly from different sources like Internet, Journals etc.
To have sufficient training to compile, classify and organize matters relating to pharmacy.
To train the student in presenting coherently the information collected by her.
To make the student aware of the latest aspects of pharmaceutical science.
To develop keenness in student for acquiring more and more knowledge about pharmaceutical sciences.
To create an ability among students in carrying out applied academic research on matters connected with latest development in pharmaceutical sciences.

Completion of the Graduation Research Project

The dissertation project shall be completed within one year starting in one September and finishing in the next September. Completion of the Graduation project, involves the following steps.

Presentation Procedure

Each member of the Pharmacy College staff or of the teaching panel from the Medical College shall suggest a few topics in right proportion to the number of students.
The selected topics shall be notified to the students at the end of the 2nd semester of the 3rd year.
Each student shall select six essays and one research topic by the end of June.

Procedure for selection and registration of topics for Graduation Research Project

Each staff member teaching in B. Pharm. gives a list of six essay topics and two research topics in his/her area of specialization to the Dean.
All essay and research Project topics shall be notified to the students at the end of the 2nd semester of the 3rd year.
Each group of two students selects from this list six essay topics and one research topic latest by 30th June.
These essay and research topics shall be registered with the Supervisors latest by 10th July.
The College Council shall approve research and essay topics and appoint the Supervisors.

Collection of data for Graduation Research Project

Dubai Pharmacy College provides sufficient facilities to the students for conducting the research and writing the Project.

Facilities for Project writing

Drug Information Center of Dubai Pharmacy College.
Central Library of Dubai Pharmacy College.
Internet facility provided by Dubai Pharmacy College.
Computers available in the College.
Library of Dubai Hospital.

Facilities for Research work of Project

Science Laboratories of Dubai Pharmacy College.
Science Laboratories of Dubai Medical College for Girls.
Instrumentation facilities of Central Laboratory of the Foundation.
Dubai Government hospitals under the Ministry of Health.
Pharmaceutical Companies.
Some general pharmacies.

Typing and designing of the Project’s dissertation

The typing and designing of the Project’s dissertation should be done as per the following guidelines.
The design of the cover page of the Project’s dissertation should be as given below:

The second page should have the contents of the Project’s dissertation.
The third page should have Part-I of Project essay topic number-I.
The fourth page should have the design as shown below

Pages following the one containing the Project topic I, should have the following:
- Synopsis of the study.
- The data given in support of the topic should be systematic, with reference numbers.
- The tables or figures given at the end of each project should be numbered properly.
- All lists and figures must be numbered.

After finishing the Project topic I the same pattern should be followed in writing the other Project essays.
After this , in the stage of writing the research work follow the pattern given below:

All the above mentioned points should be discussed with the concerned Supervisor. Rough copy should be got checked and approved from the Supervisor before the final copy is made.

project topics in chemistry and pharmaceutics

2012-07-31T02:09:00.002-07:00

Method Development of Capecitabine HCl by HPLC

Method Development of Resveratrol by HPLC

Method Development of Ropinarole by HPLC

Method Development of Gefitinib by HPLC

Method Development of Dorzolamide by HPLC

Estimation of Esomeprazole Magnesium in Pharma Dosage Forms by HPLC

Estimation of Fluconazole in Pharma Dosage Forms by HPLC

Estimation of Loratadine in Pharma Dosage Forms by HPLC

Estimation of Quetiapine Femarate in Pharma Dosage Forms by HPLC

Estimation of Gabapentin in Pharma Dosage Forms by HPLC

UV Visible Method For Estimation Of Rebaprazole Sodium in the Dosage Forms

UV Visible Method For Estimation Of Pentoprazole Sodium in the Dosage Forms

UV Visible Method For Estimation Of Tadalafil in the Dosage Forms

UV Visible Method For Estimation Of Sertraline HCl in the Dosage Forms

UV Visible Method For Estimation Of Irbesatran HCl in the Dosage Forms

Simultaneous Estimation of Omeprazole and Domperidone by HPLC

Simultaneous Estimation of Metformine HCl and Pioglitazole by HPLC

Simultaneous Estimation of Rabeprazole and Domperidone by HPLC

Simultaneous Estimation of Nebivolol and Hydrochlorothiazide by HPLC

Simultaneous Estimation of Cefixime and Ornidazole by HPLC

RP- HPLC Method Development of Ofloxacin and Ornidazole by HPLC

RP- HPLC Method Development of Montelukaust Sodium and Cetrizine by HPLC

RP- HPLC Method Development of Amlodipine and Atorvostatine by HPLC

RP- HPLC Method Development of Lamividine and Zodovidine by HPLC

RP- HPLC Method Development of Losartan Potassium and Rosuvastatine by HPLC

Dissolution Studies of Metformine Sustain Release Pellets

Dissolution Studies of Diclofenac Sodium Sustain Release Pellets

Dissolution Studies of Indomethacin Sustain Release Pellets

Dissolution Studies of Cefixime Immediate Release Pellets

Dissolution Studies of Pentoprazole Sodium Enteric Coated Release Pellets

format for m.pharm and b. pharm synopsis

2012-07-21T07:01:00.000-07:00

“DESIGN AND DEVELOPMENT OF ---------------------------------- FOR ------------- DELIVERY”

Synopsis for M.Pharm Dissertation submitted to the

------------------------- Universit , District , STATE.

By

Name of Student

M.Pharm. SEM-I/II/III/IV

B.Pharm. Sem-I/II/III/IV/V/VI/VII/VIII

SHAPE \* MERGEFORMAT

Mono of the university

Under the guidance of

Name of Guide, M.Pharm, Ph.D. (Qualification)

Department of Pharmaceutics,/Pharmacognosy/Pharmacology…..(As correct)

Name and address of college

Year (e.g. 2012-2013)

RAJIV GANDHI UNIVERSITY OF HEALTH SCIENCES,

KARNATAKA, BANGALORE.

ANNEXURE II

PROFORMA FOR REGISTRATION OF SUBJECTS FOR DISSERTATION

1.	NAME OF THE CANDIDATE AND ADDRESS (IN BLOCK LETTERS)
2.	NAME OF THE INSTITUTION
3.	COURSE OF STUDY AND SUBJECT
4.	DATE OF ADMISSION OF COURSE
5.	TITLE OF TOPIC
6.	BRIEF RESUME OF THE INTENDED WORK 6.1 Need for the study 6.2 Review of the literature 6.3 Objectives of the study		ENCLOSURE - I ENCLOSURE - II ENCLOSURE – III
7.	MATERIALS AND METHODS 7.1 Source of data 7.2 Method of collection of data 7.3Does studies require any investigations or interventions to be conducted on patients or other human or animal? If so, please describe briefly. 7.4 Has ethical clearance been obtained from your institution in case of 7.3		ENCLOSURE – IV ENCLOSURE - V ENCLOSURE – VI ENCLOSURE – VI
8.	LIST OF REFERENCES		ENCLOSURE – VII
9.	SIGNATURE OF CANDIDATE
10.	REMARKS OF GUIDE		RECOMMENDED
11.	NAME AND DESIGNATION OF 11.1 Guide 11.2 Signature 11.3 Co guide (if any) 11.4 Signature 11.5 Head of department 11.6 Signature		Not applicable. Not applicable.
	12.1 Remarks of the Chairman and Principal 12.2 Name and designation of principal 12.3 Signature		RECOMMENDED & FORWARDED .
6.0		BRIEF RESUME OF THE INTENDED WORK ENCLOSURE - I 6.1 Need for the study ENCLOSURE - II 6.2 Review of the literature ENCLOSURE – III 6.3 Objectives of the study 1. To prepare the -------- loaded with 2. To carry out the evaluation for the prepared -----------------. 3. To study the drug polymer compatability and surface morphology of the prepared 4. To carry out the in vitro release studies and stability studies of the prepared MATERIALS AND METHODS: DRUG : POLYMERS : SOLVENTS : Methods Preparation of --------- by · Evaluation ENCLOSURE – IV 7.1. Source of data a. Library: College of Pharmacy. b. E-library: College of Pharmacy. ENCLOSURE-V 7.2. Method of collection of data 1.Literature search. 2.Laboratory experiments. 3.--- -------------------other studies A) Preparation B) Characterization: ENCLOSURE – VI 7.3. Does the study require any investigation or intervention to be conducted on patients or other humans or animals? If so, please mention briefly. -YES- 7.4. Has ethical clearance been obtained from your institution in case of 7.3? -IN PROCESS- ENCLOSURE – VII LIST OF REFERENCES: 1. 2. Maheshwari RK, Singh AK, Gaddipati J, Srimal RC. Multiple biological activities of curcumin:a short review. Life Sci 2006;78;2081–2087. 3. Arvind Sharma, Subheet jain, Manu modi , Vikrant Vashisht, Harpreet singh. Chitosan based biodegradable nanoparticles. Rjpbcs 2010;1;78-88. 4. Hiroki Sasaki, Yoichi Sunagawa, Kenji Takahashi, Atsushi Imaizumi, Hiroyuki Fukuda, Tadashi Hashimoto, Hiromichi Wada, Yasufumi Katanasaka, Hideaki Kakeya,Masatoshi Fujita, Koji Hasegawa and Tatsuya Morimoto. Innovative Preparation of Curcumin for Improved Oral Bioavailability Biol. Pham 2011;34; 660-665.

http://www.csvtu.ac.in/pdf_doc/Manual%20for%20Thesis%20Writing.pdf

2012-07-17T18:18:00.000-07:00

http://siddharthapharmacy.com/pdf/M%20Pharm_Synopsis_Repost.pdf Synopsis format dehradoon univerity

SYNOPSIS REPORT format

2012-07-17T18:09:00.000-07:00

It must contain the elements given in the listing below:
1) Cover sheet
2) Title page
3) Certificate page (From outside and/or Institute)
4) Declaration
5) Table of Contents
6) Introduction
7) Plan of work
8) Title of the proposed project
9) Aim and objectives
10) Literature survey and Research envisaged
11) Methodology/Schedule of activities
12) Achievements till date
13) Remaining Work
14) Solution to problems (if any)
15) Bibliography

The format may vary depending on universities/ courses/ ordinance.

Pharmacy project synopsis guidelines

2012-07-17T18:03:00.001-07:00

GUIDELINES FOR PREPARING SYNOPSIS REPORT:
1. Paper Size = A4
2. Spacing between Lines = 1.5 inch
3. Font Size = 12
4. Fonts = Times New Roman / Book Antiqua
5. Left Margin = 1.3 inch
6. Right Margin = 0.8 inch
7. Top Margin = 1.2 inch
8. Bottom Margin = 1.2 inch
9. Header Contents: Short Title of Project
10. Footer Contents: College/Institute name and page number lower right side
11. Hard Bound File

2012-07-17T00:47:00.001-07:00

Pharmacy is the health profession that links the health sciences with the chemical sciences and it is charged with ensuring the safe and effective use of pharmaceutical drugs. The word derives from the Greek: φάρμακον (pharmakon), meaning "drug" or "medicine" (the earliest form of the word is the Mycenaean Greek pa-ma-ko, attested in Linear B syllabic script
The field of Pharmacy can generally be divided into four primary disciplines:

Project work planning
The project plan is one of the most important and useful documents in your toolkit, and should be referred to and updated throughout the project lifecycle. Its initial purpose is to kick-start the project by convincing the decision makers (usually the people who control the funds e.g. the Project Board or Steering Committee) that the project is viable and will meet their needs and timeframes, budgets, expectations. If the project plan is poorly written or contains insufficient detail, the project may not even get past this first decision gate and may never actually get off the ground. Many viable projects have floundered at this stage due to poor planning and communication. On the flip side, if you can deliver a great project plan, it establishes your credibility as a project manager, starts the project on a sound footing, and provides the team with a mandate for action and a clear direction to follow.

pharma researcher

Anish Chandy, Preti k suresh, p H -Responsive and Mucoadherent Microparticles for Oral Delivery of Serratiopeptidase: Development and In Vitro Characterization, RJPBCS Volume 2 Issue 4 Page No. 662

Data wastage due to slow internet

Ready to submit synopsis/ thesis

Novel herbal formulation

how to do reserch in pharmacology

Pharmacological Research

Topics you can work further

How to face interview

Some tips in answering:

Sample answers:

The reasons of this question:

2. Levels of career goals:

Answer tips

Answer samples

Answer tips

Answer sample

Answer tips

1. Ways to answer:

2. Steps to answer:

love and thanks to dear friends

Paid assistance in project "No Tension WORK"

HOW TO CONVINCE YOUR GUIDE

HOW TO CONVINCE YOUR GUIDE

BEST OF LUCK TO YOU ALL

CSVTU

topics hospital pharmacy: Review Reserch

image

new fresh topics for project

new topics

project topics in chemistry and pharmaceutics

format for m.pharm and b. pharm synopsis

Synopsis for M.Pharm Dissertation submitted to the

By

RAJIV GANDHI UNIVERSITY OF HEALTH SCIENCES,

KARNATAKA, BANGALORE.

PROFORMA FOR REGISTRATION OF SUBJECTS FOR DISSERTATION

NAME OF THE INSTITUTION

COURSE OF STUDY AND SUBJECT

MATERIALS AND METHODS

7.1 Source of data

7.2 Method of collection of data

7.3Does studies require any investigations or interventions to be conducted on patients or other human or animal? If so, please describe briefly.

7.4 Has ethical clearance been obtained from your institution in case of 7.3

SYNOPSIS REPORT format

Pharmacy project synopsis guidelines