Physical Sciences / Chemistry -- New results matching your topic search. https://www.pnas.org/action/doSearch?af=R Proceedings of the National Academy of Sciences: Chemistry Proceedings of the National Academy of Sciences en-US http://www.atypon.com/images/atypon_logo_small.gif http://www.atypon.com https://www.pnas.org/doi/abs/10.1073/pnas.2518381123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 15, April 2026. <br/>SignificanceFerroelectric anomalous photovoltaic (APV) effect holds a great promise in the new optoelectronic application fields. Nevertheless, the limited understanding of ferroelectric APV effect mechanism hinders the exploration of new APV-active ... Shift current anomalous photovoltaics in a double perovskite ferroelectric doi:10.1073/pnas.2518381123 2026-04-07T07:00:00Z Linjie WeiFu LiYi LiuHongbin ZhangJunhua LuoZhihua SunaState Key Laboratory of Functional Crystals and Devices, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, People’s Republic of ChinabUniversity of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing 100039, People’s Republic of ChinacDepartment of Materials and Earth Sciences, Technical University of Darmstadt, Darmstadt 64287, GermanydFujian Science & Technology Innovation Laboratory for Optoelectronic Information of China, Fuzhou, Fujian 350108, People’s Republic of China Proceedings of the National Academy of Sciences 123 15 2026-04-14T07:00:00Z 2026-04-14T07:00:00Z 10.1073/pnas.2518381123 https://www.pnas.org/doi/abs/10.1073/pnas.2518381123?af=R https://www.pnas.org/doi/abs/10.1073/pnas.2528666123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 15, April 2026. <br/>SignificanceBiofilms are ubiquitous, capable of thriving in diverse and often hostile environments. Yet, the mechanisms behind their success remain poorly understood. To gain a foundational understanding of biofilm survival, we show that tuning matrix ... Extracellular matrix chemistry tunes bacterial biofilm metabolism and optimizes fitness doi:10.1073/pnas.2528666123 2026-04-06T07:00:00Z Jinyang LiGeorgia R. SquyresKathy DuongCourtney ReichhardtMatthew R. ParsekDianne K. NewmanaDivision of Biology and Biological Engineering, Caltech, Pasadena, CA 91125bDepartment of Chemistry, Washington University, St. Louis, MO 63130cDepartment of Microbiology, University of Washington, Seattle, WA 98195dDivision of Geological and Planetary Sciences, Caltech, Pasadena, CA 91125 Proceedings of the National Academy of Sciences 123 15 2026-04-14T07:00:00Z 2026-04-14T07:00:00Z 10.1073/pnas.2528666123 https://www.pnas.org/doi/abs/10.1073/pnas.2528666123?af=R https://www.pnas.org/doi/abs/10.1073/pnas.2606250123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 15, April 2026. <br/> Structural innovation and flexibility in plant chemical defenses doi:10.1073/pnas.2606250123 2026-04-06T07:00:00Z Martin VolfaBiology Centre, Institute of Entomology, Czech Academy of Sciences, Ceske Budejovice 370 05, Czech RepublicbFaculty of Science, Department of Zoology, University of South Bohemia, Ceske Budejovice 370 05, Czech Republic Proceedings of the National Academy of Sciences 123 15 2026-04-14T07:00:00Z 2026-04-14T07:00:00Z 10.1073/pnas.2606250123 https://www.pnas.org/doi/abs/10.1073/pnas.2606250123?af=R https://www.pnas.org/doi/abs/10.1073/pnas.2518221123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 14, April 2026. <br/>SignificanceThis study is motivated by a previously understudied natural pharmacophore, the spirocyclic β-lactone (SβL). This structurally distinct, potentially electrophilic pharmacophore is found in the oxazolomycin family of natural products known to ... Spirocyclic β-lactone secondary metabolites modulate spliceosome function doi:10.1073/pnas.2518221123 2026-03-31T07:00:00Z Kathryn E. PentonSydney A. BatesHannah L. ThirmanCrissey D. CameronChristopher JurichMadeline J. Grider-HayesMing JiangMichael R. SavonaZhongyue J. YangLars PlateJonathan M. IrishBrian O. BachmannaDepartment of Chemistry, Vanderbilt University, Nashville, TN 37232bVanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, TN 37232cDepartment of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37232dChemical & Physical Biology Program, Vanderbilt University, Nashville, TN 37232eDepartment of Pediatrics-Neurology, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045fDepartment of Internal Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232gProgram in Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37232hCenter for Structural Biology, Vanderbilt University, Nashville, TN 37235iVanderbilt University Data Science Institute, Nashville, TN 37235jDepartment of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN 37235 Proceedings of the National Academy of Sciences 123 14 2026-04-07T07:00:00Z 2026-04-07T07:00:00Z 10.1073/pnas.2518221123 https://www.pnas.org/doi/abs/10.1073/pnas.2518221123?af=R https://www.pnas.org/doi/abs/10.1073/pnas.2534956123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 14, April 2026. <br/>SignificanceSinglet oxygen (1O2) drives key photochemical reactions in the atmosphere and natural waters, yet its spatial distribution in multiphase systems remains unexplored. Here, we reveal strong microscale enrichment of1O2at the air–water interface,... Microheterogeneous singlet oxygen generation at air–water interfaces doi:10.1073/pnas.2534956123 2026-04-01T07:00:00Z Shaoping MiYe-Guang FangXiaochen LiuXiaoshan ZhengHongbo MingXiaojiao LiBaoliang ChenChongqin ZhuKristopher McNeillChiheng ChuaState Key Laboratory of Soil Pollution Control and Safety, Department of Environmental Science, Institute of Fundamental and Transdisciplinary Research, Zhejiang University, Hangzhou 310058, ChinabCollege of Chemistry, Key Laboratory of Theoretical and Computational Photochemistry of Ministry of Education, Beijing Normal University, Beijing 100875, ChinacInstitute of Biogeochemistry and Pollutant Dynamics, Department of Environmental Systems Science, ETH Zürich, Zürich 8092, Switzerland Proceedings of the National Academy of Sciences 123 14 2026-04-07T07:00:00Z 2026-04-07T07:00:00Z 10.1073/pnas.2534956123 https://www.pnas.org/doi/abs/10.1073/pnas.2534956123?af=R https://www.pnas.org/doi/abs/10.1073/pnas.2504045123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 13, March 2026. <br/>SignificanceInfluenza remains a major global health threat. We introduce oseltamivir-based aziridines that unite transition-state mimicry for tight binding with aziridine-enabled covalent capture of the catalytic tyrosine. This dual function yields potent,... Oseltamivir aziridines are potent influenza neuraminidase inhibitors and imaging agents doi:10.1073/pnas.2504045123 2026-03-23T07:00:00Z Merijn B. L. VriendsElisha MoranMartín CalveloThomas HansenIsabelle B. PicklesXincheng XinMarieke BiezenoZachary W. B. ArmstrongMaria J. FerrazLei LiAlice LilleyRuth HarveyDmitri V. FilippovQinghua LiaoSybrin P. SchröderGijsbert A. van der MarelMarta ArtolaJohannes M. F. G. AertsJames N. BlazaJeroen D. C. CodéeCarme RoviraHerman S. OverkleeftGideon J. DaviesaDepartment of Bio-organic Synthesis, Leiden Institute of Chemistry, Leiden University, Leiden 2300 RA, The NetherlandsbDepartment of Chemistry, University of York Heslington, York YO10 5DD, United KingdomcDepartament de Química Inorgaǹica i Orgaǹica (Seccióde Química Orgaǹica) and Institut de Química TeorÌica I Computacional, Universitat de Barcelona, Barcelona 08028, SpaindFundació Catalana de Recerca i Estudis Avancats, Barcelona 08010, SpaineDepartment of Medical Biochemistry, Leiden Institute of Chemistry, Leiden University, Leiden 2300 RA, The NetherlandsfWorldwide Influenza Centre, The Francis Crick Institute, London NW1 1AT, United Kingdom Proceedings of the National Academy of Sciences 123 13 2026-03-31T07:00:00Z 2026-03-31T07:00:00Z 10.1073/pnas.2504045123 https://www.pnas.org/doi/abs/10.1073/pnas.2504045123?af=R https://www.pnas.org/doi/abs/10.1073/pnas.2515413123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 13, March 2026. <br/>SignificanceC(sp2)–C(sp2) bonds are pivotal in pharmaceuticals, natural products, and functional organic/polymeric materials. Thus, developing robust, efficient methods to construct C(sp2)–C(sp2) linkages is an important objective in synthetic chemistry. ... General and selective nickel-electrocatalyzed cross-electrophile C*(sp2)–C(sp2) coupling doi:10.1073/pnas.2515413123 2026-03-23T07:00:00Z Wenbin XieZhe SongQinqin ShiPanping ShengGu XuKaikai WenLutang ZhaoTobin J. MarksZhi-Xiang WangHui HuangaCollege of Materials Science and Opto-Electronic Technology, University of Chinese Academy of Sciences, Beijing 100049, P. R. ChinabSchool of Chemical Sciences, University of Chinese Academy of Sciences, Beijing 100049, P. R. ChinacBeijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing 100140, P. R. ChinadDepartment of Chemistry and the Materials Research Center, Northwestern University, Evanston, IL 60208eCenter of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing 100049, P. R. ChinafSchool of Chemical Engineering and Technology, State Key Laboratory of Chemical Engineering and Low-Carbon Technology, Tianjin University, Tianjin 300072, P. R. China Proceedings of the National Academy of Sciences 123 13 2026-03-31T07:00:00Z 2026-03-31T07:00:00Z 10.1073/pnas.2515413123 https://www.pnas.org/doi/abs/10.1073/pnas.2515413123?af=R https://www.pnas.org/doi/abs/10.1073/pnas.2515805123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 13, March 2026. <br/>SignificanceOrigin of life strongly relies on reactive carbon and nitrogen precursors, among which hydrogen cyanide (HCN) is one of the most versatile molecules that can be used for synthesizing almost all essential biomolecules. However, recent ... Mineral-facilitated aqueous synthesis of hydrogen cyanide from prebiotically abundant amino acids for chemical evolution doi:10.1073/pnas.2515805123 2026-03-23T07:00:00Z Zening YangYamei LiNorio KitadaiMasahiro YamamotoYuichiro UenoYanjing LuAilong LiKiyohiro AdachiAkira YamaguchiDaisuke HashizumeRyuhei NakamuraaEarth-Life Science Institute, Institute of Future Science, Institute of Science Tokyo, Meguro-ku, Tokyo 152-8550, JapanbDepartment of Chemical Science and Engineering, School of Materials and Chemical Technology, Institute of Science Tokyo, Ookayama, Meguro-ku, Tokyo 152-8552, JapancBiofunctional Catalyst Research Team, RIKEN Center for Sustainable Resource Science, Wako, Saitama 351-0198, JapandInstitute for Extra-Cutting-Edge Science and Technology Avant-Garde Research, Japan Agency for Marine-Earth Science and Technology, Yokosuka 237-0061, JapaneDepartment of Earth and Planetary Sciences, Institute of Science Tokyo, Meguro-ku, Tokyo 152-8551, JapanfMaterials Characterization Support Team, RIKEN Center for Emergent Matter Science, Wako, Saitama 351-0198, JapangDepartment of Materials Science and Engineering, School of Materials and Chemical Technology, Institute of Science Tokyo, Ookayama, Meguro-ku, Tokyo 152-8552, Japan Proceedings of the National Academy of Sciences 123 13 2026-03-31T07:00:00Z 2026-03-31T07:00:00Z 10.1073/pnas.2515805123 https://www.pnas.org/doi/abs/10.1073/pnas.2515805123?af=R https://www.pnas.org/doi/abs/10.1073/pnas.2518463123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 13, March 2026. <br/>SignificancePlatinum (Pt)-based catalysts are vital yet costly for proton exchange membrane fuel cells (PEMFC). While well-defined nanostructures enhance Pt utilization and stability, their dense structures impede mass transport, limiting practical ... Microstrain-engineered platinum nanoclathrins for fuel cells doi:10.1073/pnas.2518463123 2026-03-25T07:00:00Z Zhiyong YuQing YaoChen SunLiangqun ZhaoYonggang FengRui QinFei XueXueli YanZhiwei HuWei-Hsiang HuangChih-Wen PaoLili HanNanjun ChenXiaoqing HuangaState Key Laboratory of Physical Chemistry of Solid Surfaces, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, ChinabState Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, ChinacSchool of Chemical Sciences, University of Chinese Academy of Sciences, Beijing 101408, ChinadInnovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province, Xiamen 361005, ChinaeCoKey Lab of Advanced Energy Storage and Conversion, Zhejiang Province Key Lab of Leather Engineering, College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou, Zhejiang 325035, ChinafInternational Research Center for Renewable Energy, State Key Laboratory of Multiphase Flow in Power Engineering, Xi’an Jiaotong University, Xi’an 710049, ChinagMax Planck Institute for Chemical Physics of Solids, Dresden 01187, GermanyhNational Synchrotron Radiation Research Center, Hsinchu 30076, Taiwan Proceedings of the National Academy of Sciences 123 13 2026-03-31T07:00:00Z 2026-03-31T07:00:00Z 10.1073/pnas.2518463123 https://www.pnas.org/doi/abs/10.1073/pnas.2518463123?af=R https://www.pnas.org/doi/abs/10.1073/pnas.2527861123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 13, March 2026. <br/>SignificanceSolar-driven photocatalysis holds promise for sustainable and cost-efficient energy and chemical production, yet its advancement is hindered by the lack of in operando technique to understand charge-carrier behavior at the nanoscale. Here, we ... Probing charge-transfer processes in Pt/TiO2 photocatalysts by amperometric/potentiometric photo-SECM doi:10.1073/pnas.2527861123 2026-03-26T07:00:00Z Tianyu BoHaoqing SuZiyuan WangJe Hyun BaeGaukhar AskarovaShu HuMichael V. MirkinaDepartment of Chemistry and Biochemistry, Queens College, Flushing, NY 11367bThe Graduate Center of The City University of New York, New York, NY 10016cDepartment of Chemical and Environmental Engineering, Yale University, New Haven, CT 06510dEnergy Sciences Institute, Yale West Campus, West Haven, CT 06516eAdvanced Science Research Center of The City University of New York, New York, NY 10031 Proceedings of the National Academy of Sciences 123 13 2026-03-31T07:00:00Z 2026-03-31T07:00:00Z 10.1073/pnas.2527861123 https://www.pnas.org/doi/abs/10.1073/pnas.2527861123?af=R https://www.pnas.org/doi/abs/10.1073/pnas.2534303123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 13, March 2026. <br/>SignificanceWater’s anomalous properties emerge from its complex hydrogen-bond networks in the liquid phase, which are difficult to model accurately. Quantum-level accuracy typically entails prohibitive computational costs, limiting large-scale ... Energy landscape statistics and thermodynamics of a machine-learned model of water doi:10.1073/pnas.2534303123 2026-03-26T07:00:00Z Ryan J. SzukaloAndreas NeophytouAxel GomezNicolas GiovambattistaFrancesco SciortinoPablo G. DebenedettiaDepartment of Chemistry, Princeton University, Princeton, NJ 08544bDipartimento di Fisica, Sapienza Università di Roma, Roma 00185, ItalycDepartment of Physics, Brooklyn College of the City University of New York, Brooklyn, NY 11210dPh.D. Programs in Physics and Chemistry, The Graduate Center of the City University of New York, New York, NY 10016eDepartment of Chemical and Biological Engineering, Princeton University, Princeton, NJ 08544 Proceedings of the National Academy of Sciences 123 13 2026-03-31T07:00:00Z 2026-03-31T07:00:00Z 10.1073/pnas.2534303123 https://www.pnas.org/doi/abs/10.1073/pnas.2534303123?af=R https://www.pnas.org/doi/abs/10.1073/pnas.2529780123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 12, March 2026. <br/>SignificancePeptides synthesized at the ribosome and then posttranslationally modified by enzymes constitute an important class of natural products with antibiotic and antiviral properties. An important type of posttranslational modification is the ... The radical SAM enzyme EpeE exhibits distinct site reactivity during the biosynthesis of the RiPP natural product epipeptide doi:10.1073/pnas.2529780123 2026-03-18T07:00:00Z William G. WallsHao YangMadeline B. HoWilliam E. BroderickBrian M. HoffmanJoan B. BroderickaDepartment of Chemistry & Biochemistry, Montana State University, Bozeman, MT 59717bDeparment of Chemistry, Northwestern University, Evanston, IL 60208 Proceedings of the National Academy of Sciences 123 12 2026-03-24T07:00:00Z 2026-03-24T07:00:00Z 10.1073/pnas.2529780123 https://www.pnas.org/doi/abs/10.1073/pnas.2529780123?af=R https://www.pnas.org/doi/abs/10.1073/pnas.2531136123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 12, March 2026. <br/>SignificanceMaterials that assemble through chemical reactions are often designed with the expectation that fluctuations and inhomogeneities will relax toward a steady state, reflecting the equilibrium intuition commonly associated with Le Chatelier’s ... Transiently amplified fluctuations assemble dissipative materials doi:10.1073/pnas.2531136123 2026-03-18T07:00:00Z Tae Hyun UeonJoseph P. PattersonJason R. GreenaDepartment of Chemistry, University of Massachusetts Boston, Boston, MA 02125bDepartment of Chemistry, University of California, Irvine, CA 92697-2025cDepartment of Materials Science and Engineering, University of California, Irvine, CA 92697-2025dDepartment of Physics, University of Massachusetts Boston, Boston, MA 02125 Proceedings of the National Academy of Sciences 123 12 2026-03-24T07:00:00Z 2026-03-24T07:00:00Z 10.1073/pnas.2531136123 https://www.pnas.org/doi/abs/10.1073/pnas.2531136123?af=R https://www.pnas.org/doi/abs/10.1073/pnas.2531153123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 12, March 2026. <br/>SignificanceInspired by the periodic porous membrane and breathing process of the mammalian respiratory system, a steady nonequilibrium sensing process is established to achieve high-accuracy gas discrimination based on artificial periodic porous ... Bioinspired periodic mesoporous tin oxides enable steady nonequilibrium chemical sensing for enhanced gas discrimination doi:10.1073/pnas.2531153123 2026-03-18T07:00:00Z Keyu ChenYu DengTianming HuJichun LiXin-Yu HuangChengcheng ZhuHonggang ChenMeihua ChenLimin WuYonghui DengWenhe XieaDepartment of Chemistry, Shanghai Stomatological Hospital and School of Stomatology, State Key Laboratory of Coatings for Advanced Equipment, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University, Shanghai 200433, P. R. ChinabState Key Laboratory of Advanced Fiber Materials, Department of Materials Science and Engineering, College of Materials Science and Engineering, Donghua University, Shanghai 201620, P. R. ChinacInstitute of Energy and Materials Chemistry, Inner Mongolia University, Hohhot 010021, P. R. China Proceedings of the National Academy of Sciences 123 12 2026-03-24T07:00:00Z 2026-03-24T07:00:00Z 10.1073/pnas.2531153123 https://www.pnas.org/doi/abs/10.1073/pnas.2531153123?af=R https://www.pnas.org/doi/abs/10.1073/pnas.2534305123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 12, March 2026. <br/>SignificanceThe sluggish hydrogen oxidation reaction (HOR) remains a major barrier to eliminating the reliance on precious group metal (PGM) catalysts in fuel cells. Here, we elucidate the role of graphene in stabilizing metallic Ni surfaces against ... Unveiling the sensitivity and significance of the Ni oxidation state for alkaline hydrogen oxidation electrocatalysis doi:10.1073/pnas.2534305123 2026-03-18T07:00:00Z Qihao LiZixiao ShiColin R. BundschuChristopher J. PollockAndrés Molina VillarinoMihail R. KrumovRui ZengDavid A. MullerHéctor D. AbruñaaDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853bSchool of Applied and Engineering Physics, Cornell University, Ithaca, NY 14853cCornell High Energy Synchrotron Source, Wilson Laboratory, Cornell University, Ithaca, NY 14853dKavli Institute at Cornell for Nanoscale Science, Cornell University, Ithaca, NY 14853 Proceedings of the National Academy of Sciences 123 12 2026-03-24T07:00:00Z 2026-03-24T07:00:00Z 10.1073/pnas.2534305123 https://www.pnas.org/doi/abs/10.1073/pnas.2534305123?af=R https://www.pnas.org/doi/abs/10.1073/pnas.2515214123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 11, March 2026. <br/>SignificancePhotoprotection is essential for cyanobacteria to prevent light-induced damage, and the orange carotenoid protein (OCP) plays a central role in this process. Although the structural changes associated with OCP photoactivation have been ... Atomistic simulations reveal the photoactivation mechanism of a carotenoid-binding photoreceptor doi:10.1073/pnas.2515214123 2026-03-12T07:00:00Z Amanda ArcidiaconoMattia BondanzaLorenzo CupelliniBenedetta MennucciaDepartment of Chemistry and Industrial Chemistry, University of Pisa, Pisa 56124, Italy Proceedings of the National Academy of Sciences 123 11 2026-03-17T07:00:00Z 2026-03-17T07:00:00Z 10.1073/pnas.2515214123 https://www.pnas.org/doi/abs/10.1073/pnas.2515214123?af=R https://www.pnas.org/doi/abs/10.1073/pnas.2524561123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 11, March 2026. <br/>SignificanceAqueous zinc-ion batteries (ZIBs) are promising next-generation energy-storage systems owing to their intrinsic safety, low cost, resource abundance, and high-power density. In aqueous ZIBs, electrolytes—zinc salts dissolved in water—govern ... Anion-mediated solvation structures and intercalation chemistry of aqueous zinc-ion electrolytes doi:10.1073/pnas.2524561123 2026-03-12T07:00:00Z Shiqiang WeiQuan ZhouShuangming ChenYixiu WangPengjun ZhangWei JiangChangda WangJiewu CuiXiaojun WuLi SongaNational Synchrotron Radiation Laboratory, State Key Laboratory of Precision and Intelligent Chemistry, University of Science and Technology of China, Hefei, Anhui 230029, P. R. ChinabKey Laboratory of Advanced Functional Materials and Devices of Anhui Province, Hefei University of Technology, Hefei, Anhui 230029, P. R. ChinacSchool of Chemistry and Material Sciences, University of Science and Technology of China, Hefei, Anhui 230026, P.R. China Proceedings of the National Academy of Sciences 123 11 2026-03-17T07:00:00Z 2026-03-17T07:00:00Z 10.1073/pnas.2524561123 https://www.pnas.org/doi/abs/10.1073/pnas.2524561123?af=R https://www.pnas.org/doi/abs/10.1073/pnas.2524995123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 11, March 2026. <br/>SignificanceOver 40 million people are living with HIV, with approximately one million new infections each year. A defining feature of the virus is its conical capsid consisting of around 1,200 capsid (CA) proteins, which plays key roles across multiple ... Mechanistic insights into lenacapavir-induced off-pathway HIV-1 capsid assembly doi:10.1073/pnas.2524995123 2026-03-10T07:00:00Z Manish GuptaCurt WaltmannNadine RennerYihang WangLeo C. JamesDavid A. JacquesTill BöckingGregory A. VothaDepartment of Chemistry, Chicago Center for Theoretical Chemistry, Institute for Biophysical Dynamics, and James Franck Institute, The University of Chicago, Chicago, IL 60637bMedical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, United KingdomcEuropean Molecular Biology Laboratory Australia Node in Single Molecule Science, School of Biomedical Sciences, The University of New South Wales, Sydney, NSW 2052, Australia Proceedings of the National Academy of Sciences 123 11 2026-03-17T07:00:00Z 2026-03-17T07:00:00Z 10.1073/pnas.2524995123 https://www.pnas.org/doi/abs/10.1073/pnas.2524995123?af=R https://www.pnas.org/doi/abs/10.1073/pnas.2529364123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 11, March 2026. <br/>SignificanceAmmonia is essential to food production, chemical manufacturing, and hydrogen storage, but its conventional synthesis via the Haber–Bosch process is energy-intensive and catalyst-dependent. In addition, traditional photoelectrochemical NOx−... Ambient ammonia synthesis from air via tandem water microdroplets–driven oxidation and pulsed photoelectrochemical reduction doi:10.1073/pnas.2529364123 2026-03-09T07:00:00Z Kejian LiWan Jae DongRui ShenZhengwei YeBingxing ZhangYuyang PanDeming XiaChunhua WangJoseph S. FranciscoZetian MiaDepartment of Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, MI 48109bDepartment of Integrative Energy Engineering, Graduate School of Energy and Environment (Korea University-Korea Institute of Science and Technology Green School), College of Engineering, Korea University, Seoul 02841, Republic of KoreacDepartment of Earth and Environmental Science, University of Pennsylvania, Philadelphia, PA 19104-6316 Proceedings of the National Academy of Sciences 123 11 2026-03-17T07:00:00Z 2026-03-17T07:00:00Z 10.1073/pnas.2529364123 https://www.pnas.org/doi/abs/10.1073/pnas.2529364123?af=R https://www.pnas.org/doi/abs/10.1073/pnas.2529841123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 11, March 2026. <br/>SignificanceMicrobial natural products are a rich source of therapeutic agents, yet many remain undiscovered due to the transcriptionally silent nature of their biosynthetic genes under standard laboratory conditions. Here, we present a simple and ... Leveraging antibiotic hormesis for cryptic natural product discovery doi:10.1073/pnas.2529841123 2026-03-09T07:00:00Z Joon Soo AnEllysia N. OvertonMohammad R. SeyedsayamdostaDepartment of Chemistry, Princeton University, Princeton, NJ 08544bDepartment of Molecular Biology, Princeton University, Princeton, NJ 08544 Proceedings of the National Academy of Sciences 123 11 2026-03-17T07:00:00Z 2026-03-17T07:00:00Z 10.1073/pnas.2529841123 https://www.pnas.org/doi/abs/10.1073/pnas.2529841123?af=R https://www.pnas.org/doi/abs/10.1073/pnas.2534439123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 11, March 2026. <br/>SignificanceTargeted intracellular delivery of large therapeutic molecules remains a major challenge, limiting the potential of cancer-targeted therapy, RNA-based drugs, and gene-editing treatments. Here, we present Sonoporation-assisted Precise ... SonoPIN enables precise, noninvasive, and efficient intracellular delivery of PROTACs doi:10.1073/pnas.2534439123 2026-03-13T07:00:00Z Yuqi WuMingyuan LiuKe LiShanglin LiLai Yee PhoonJohn MaiYing ChenWei YanShu Nakajima LanJoseph RufoGraham MilfordYe HeQian WuShujie YangLi LanStephen J. BenkovicTony Jun HuangaThomas Lord Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC 27708bDepartment of Electrical and Computer Engineering, Duke University, Durham, NC 27708cDepartment of Molecular Genetics and Microbiology, Duke University, Durham, NC 27708dAlfred E. Mann Department of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089eDepartment of Pharmacology, The Long School of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229fDepartment of Chemistry, Pennsylvania State University, State College, PA 16802 Proceedings of the National Academy of Sciences 123 11 2026-03-17T07:00:00Z 2026-03-17T07:00:00Z 10.1073/pnas.2534439123 https://www.pnas.org/doi/abs/10.1073/pnas.2534439123?af=R https://www.pnas.org/doi/abs/10.1073/pnas.2535853123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 11, March 2026. <br/>SignificanceThis work provides the strongest empirical test to date of how structural innovation in plant metabolism creates an evolutionary axis of novel defensive bioactivity and ecological opportunity. In this case, biosynthetic modifications to ... Structural innovation in the evolution of plant chemical defense doi:10.1073/pnas.2535853123 2026-03-12T07:00:00Z Paola Rubiano-BuitragoAmy P. HastingsMasaaki UematsuJeremy M. BaskinAnurag A. AgrawalChristophe DuplaisaDepartment of Ecology and Evolutionary Biology, Cornell University, Ithaca, NY 14853bDepartment of Chemistry and Chemical Biology and Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY 14853cDepartment of Entomology, Cornell University, Ithaca, NY 14853dDepartment of Entomology, Cornell AgriTech, Cornell University, Geneva, NY 14456 Proceedings of the National Academy of Sciences 123 11 2026-03-17T07:00:00Z 2026-03-17T07:00:00Z 10.1073/pnas.2535853123 https://www.pnas.org/doi/abs/10.1073/pnas.2535853123?af=R https://www.pnas.org/doi/abs/10.1073/pnas.2537547123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 11, March 2026. <br/>SignificanceIt has long been observed that cancer patients respond differently to the same cytotoxic chemotherapeutic agent. We are proposing here that cytotoxicity-induced viral mimicry contributes to so-called immunogenic cell death and could represent ... Viral mimicry may help explain immunogenic cell death doi:10.1073/pnas.2537547123 2026-03-11T07:00:00Z Matthew S. LevineJiexi LiLauren I. R. EhrlichRonald A. DePinhoBrent IversonJonathan L. SessleraDepartment of Chemistry, The University of Texas at Austin, Austin, TX 78712-1224bDepartment of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77054.cDepartment of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712-0159 Proceedings of the National Academy of Sciences 123 11 2026-03-17T07:00:00Z 2026-03-17T07:00:00Z 10.1073/pnas.2537547123 https://www.pnas.org/doi/abs/10.1073/pnas.2537547123?af=R https://www.pnas.org/doi/abs/10.1073/pnas.2600921123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 11, March 2026. <br/> A computational microscope for fluctuations: Bringing crystal nucleation into focus doi:10.1073/pnas.2600921123 2026-03-09T07:00:00Z Pablo M. PiaggiaCIC nanoGUNE BRTA, Donostia-San Sebastián 20018, SpainbIkerbasque, Basque Foundation for Science, Bilbao 48013, Spain Proceedings of the National Academy of Sciences 123 11 2026-03-17T07:00:00Z 2026-03-17T07:00:00Z 10.1073/pnas.2600921123 https://www.pnas.org/doi/abs/10.1073/pnas.2600921123?af=R