research - The Chandran Labhttps://www.chandranlab.org/blog/Fri, 08 Aug 2025 12:20:13 +0000en-USSite-Server v@build.version@ (http://www.squarespace.com)High-resolution in situ structures of hantavirus glycoprotein tetramersKartik ChandranFri, 27 Feb 2026 17:00:00 +0000/guo202654629d11e4b03a44d1209d37:565b5ed8e4b0e91a03c4c997:69b5777ea20327003feba853Guo et al, Cell 2026

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]]>High-resolution in situ structures of hantavirus glycoprotein tetramersRASP: rapid antibody functional screening by pentavalent phage displayKartik ChandranMon, 09 Feb 2026 17:00:00 +0000/kaur202654629d11e4b03a44d1209d37:565b5ed8e4b0e91a03c4c997:69b573fae7717d6d17f3029fKaur et al, mAbs 2026

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]]>RASP: rapid antibody functional screening by pentavalent phage displayCross-binding antibodies capable of neutralising diverse hantaviruses are produced in response to Puumala virus infectionKartik ChandranThu, 08 Jan 2026 17:00:00 +0000/clark202654629d11e4b03a44d1209d37:565b5ed8e4b0e91a03c4c997:6962b173b7c9007504f905c7Clark et al, EBiomedicine 2026

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]]>Cross-binding antibodies capable of neutralising diverse hantaviruses are produced in response to Puumala virus infectionNanoparticle Adjuvant Design Enhances Germinal Center Responses Targeting Conserved Subdominant Epitopes for Pan-Coronavirus Vaccine DevelopmentKartik ChandranWed, 10 Dec 2025 17:00:00 +0000/huang202554629d11e4b03a44d1209d37:565b5ed8e4b0e91a03c4c997:696049050219282fa845e020Huang et al, Adv Sci (Weinh) 2025

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]]>Nanoparticle Adjuvant Design Enhances Germinal Center Responses Targeting Conserved Subdominant Epitopes for Pan-Coronavirus Vaccine DevelopmentBat sarbecovirus WIV1-CoV bears an adaptive mutation that alters spike dynamics and enhances ACE2 bindingKartik ChandranThu, 16 Oct 2025 16:00:00 +0000/tse202554629d11e4b03a44d1209d37:565b5ed8e4b0e91a03c4c997:68ecc686aab6276768d5ba5aTse et al, PLoS Pathog 2025

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]]>Bat sarbecovirus WIV1-CoV bears an adaptive mutation that alters spike dynamics and enhances ACE2 bindingLRP8 is a receptor for tick-borne encephalitis virusKartik ChandranWed, 24 Sep 2025 15:00:00 +0000/mittler202554629d11e4b03a44d1209d37:565b5ed8e4b0e91a03c4c997:68e13a62c1392120dfd6f3e7Mittler et al, Nature 2025

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]]>LRP8 is a receptor for tick-borne encephalitis virusInfluence of CCL2-mediated modulation of ALIX in the budding and replication of viruses from multiple familiesKartik ChandranTue, 23 Sep 2025 16:00:00 +0000/mofed202554629d11e4b03a44d1209d37:565b5ed8e4b0e91a03c4c997:68e5d0ad3431bd6f12a8682eMofed et al, mBio 2025

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]]>Influence of CCL2-mediated modulation of ALIX in the budding and replication of viruses from multiple familiesAvidity and variable domain spacing strongly influence the therapeutic potency of bispecific antibodies against Crimean-Congo hemorrhagic fever virusKartik ChandranWed, 14 May 2025 16:00:00 +0000/wang202554629d11e4b03a44d1209d37:565b5ed8e4b0e91a03c4c997:6895e9fee35aa02c1d89fd84Wang et al, mBio 2025

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]]>Avidity and variable domain spacing strongly influence the therapeutic potency of bispecific antibodies against Crimean-Congo hemorrhagic fever virusSuFEx-enabled high-throughput medicinal chemistry for developing potent tamoxifen analogs as Ebola virus entry inhibitors (Copy)Kartik ChandranSun, 27 Apr 2025 16:00:00 +0000/dada202554629d11e4b03a44d1209d37:565b5ed8e4b0e91a03c4c997:6895eb0312268851070ca116Dada et al, Front Immunol 2025

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]]>SuFEx-enabled high-throughput medicinal chemistry for developing potent tamoxifen analogs as Ebola virus entry inhibitors (Copy)Antibodies targeting Crimean-Congo hemorrhagic fever virus GP38 limit vascular leak and viral spreadKartik ChandranWed, 19 Feb 2025 17:00:00 +0000/pahmeier202554629d11e4b03a44d1209d37:565b5ed8e4b0e91a03c4c997:67db0f520a71a348cf70ad9dPahmeier et al, Science Transl Med 2025

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]]>Antibodies targeting Crimean-Congo hemorrhagic fever virus GP38 limit vascular leak and viral spreadStructural insights into tecovirimat antiviral activity and poxvirus resistanceKartik ChandranWed, 12 Feb 2025 17:00:00 +0000/vernuccio202554629d11e4b03a44d1209d37:565b5ed8e4b0e91a03c4c997:67db0a695a8bc72d7e3d21b8Vernuccio et al, Nat Microbiol 2025

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]]>Structural insights into tecovirimat antiviral activity and poxvirus resistanceEngineering and structures of Crimean-Congo hemorrhagic fever virus glycoprotein complexesKartik ChandranThu, 23 Jan 2025 17:00:00 +0000/mcfadden202454629d11e4b03a44d1209d37:565b5ed8e4b0e91a03c4c997:6789018934b62b1a24c6e33fMcFadden et al, Cell 2025

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]]>Engineering and structures of Crimean-Congo hemorrhagic fever virus glycoprotein complexesDecoding the blueprint of receptor binding by filoviruses through large-scale binding assays and machine learningKartik ChandranWed, 15 Jan 2025 17:00:00 +0000/lasso202554629d11e4b03a44d1209d37:565b5ed8e4b0e91a03c4c997:6789039069c37f40f710acc0Lasso et al, Cell Host & Microbe 2025

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]]>Decoding the blueprint of receptor binding by filoviruses through large-scale binding assays and machine learningDistinct pathways for evolution of enhanced receptor binding and cell entry in SARS-like bat coronavirusesKartik ChandranFri, 15 Nov 2024 17:00:00 +0000/tse202454629d11e4b03a44d1209d37:565b5ed8e4b0e91a03c4c997:673935e4078cc50796b95552Tse et al, PLoS Pathog. 2024

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]]>Distinct pathways for evolution of enhanced receptor binding and cell entry in SARS-like bat coronavirusesMPXV Infection Stimulates a More Robust and Durable Neutralizing Antibody Response Compared to MVA-BN VaccinationKartik ChandranFri, 18 Oct 2024 16:00:00 +0000/selverian202454629d11e4b03a44d1209d37:565b5ed8e4b0e91a03c4c997:673932fd60ecd260071f4420Selverian et al, J Infect Dis. 2024

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]]>MPXV Infection Stimulates a More Robust and Durable Neutralizing Antibody Response Compared to MVA-BN VaccinationSimulation-driven design of stabilized SARS-CoV-2 spike S2 immunogensKartik ChandranTue, 27 Aug 2024 16:00:00 +0000/nuqui202454629d11e4b03a44d1209d37:565b5ed8e4b0e91a03c4c997:67392ebaf69c1e1a4cc5fbc8Nuqui et al, Nat. Commun. 2024

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]]>Simulation-driven design of stabilized SARS-CoV-2 spike S2 immunogensCrimean-Congo hemorrhagic fever survivors elicit protective non-neutralizing antibodies that target 11 overlapping regions on glycoprotein GP38Kartik ChandranTue, 23 Jul 2024 18:17:00 +0000shin202454629d11e4b03a44d1209d37:565b5ed8e4b0e91a03c4c997:66c38be8e729544c4d63cd9aShin et al, Cell Rep. 2024

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]]>Crimean-Congo hemorrhagic fever survivors elicit protective non-neutralizing antibodies that target 11 overlapping regions on glycoprotein GP38A viral vaccine design harnessing prior BCG immunization confers protection against Ebola virusKartik ChandranTue, 16 Jul 2024 18:22:00 +0000ng202454629d11e4b03a44d1209d37:565b5ed8e4b0e91a03c4c997:66c38d3fec84db7fca53bedcNg et al, Front Immunol. 2024

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]]>A viral vaccine design harnessing prior BCG immunization confers protection against Ebola virusFine-tuning spatial-temporal dynamics and surface receptor expression support plasma cell-intrinsic longevityKartik ChandranTue, 18 Jun 2024 17:14:00 +0000jing202454629d11e4b03a44d1209d37:565b5ed8e4b0e91a03c4c997:66c37d26abafeb6a11932e1eJing et al, Elife. 2024

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]]>Fine-tuning spatial-temporal dynamics and surface receptor expression support plasma cell-intrinsic longevityA VHH single-domain platform enabling discovery and development of monospecific antibodies and modular neutralizing bispecifics against SARS-CoV-2 variantsKartik ChandranFri, 03 May 2024 18:11:00 +0000yang202454629d11e4b03a44d1209d37:565b5ed8e4b0e91a03c4c997:66c38a82930f4b3cc3790923Yang et al, Antib Ther. 2024

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]]>A VHH single-domain platform enabling discovery and development of monospecific antibodies and modular neutralizing bispecifics against SARS-CoV-2 variants