research - The Chandran Labhttps://www.chandranlab.org/blog/Fri, 08 Aug 2025 12:20:13 +0000en-USSite-Server v@build.version@ (http://www.squarespace.com)Expanded protocadherin-1 usage reveals a broader hantavirus entry landscapeKartik ChandranWed, 24 Jun 2026 16:00:00 +0000/word202654629d11e4b03a44d1209d37:565b5ed8e4b0e91a03c4c997:6a70db5f3634a6503ce132aaWord et al, bioRxiv 2026

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]]>Expanded protocadherin-1 usage reveals a broader hantavirus entry landscapeFinding the Goldilocks zone: Modulating glycoprotein cleavage and fusogenicity optimizes the efficacy of a candidate Crimean-Congo hemorrhagic fever virus vaccineKartik ChandranMon, 08 Jun 2026 16:00:00 +0000/berrigan202654629d11e4b03a44d1209d37:565b5ed8e4b0e91a03c4c997:6a70d7ddcea8a7536ebeaa02Berrigan et al, bioRxiv 2026

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]]>Finding the Goldilocks zone: Modulating glycoprotein cleavage and fusogenicity optimizes the efficacy of a candidate Crimean-Congo hemorrhagic fever virus vaccinePowassan Virus Seroprevalence in a U.S. Servicemember Population at High Risk for Tick ExposureKartik ChandranWed, 03 Jun 2026 16:00:00 +0000/tse202654629d11e4b03a44d1209d37:565b5ed8e4b0e91a03c4c997:6a70d5f5348ff80e0da38827Tse et al, medRxiv 2026

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]]>Powassan Virus Seroprevalence in a U.S. Servicemember Population at High Risk for Tick ExposureCrimean-Congo hemorrhagic fever virus protein GP38 from isolate M18-China confers broad immunological breadthKartik ChandranTue, 19 May 2026 16:00:00 +0000/wang202654629d11e4b03a44d1209d37:565b5ed8e4b0e91a03c4c997:6a707c20c3e965138a0b4a05Wang et al, Res Sq 2026

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]]>Crimean-Congo hemorrhagic fever virus protein GP38 from isolate M18-China confers broad immunological breadthProtective human antibodies against Powassan virusKartik ChandranThu, 30 Apr 2026 16:00:00 +0000/fallon202654629d11e4b03a44d1209d37:565b5ed8e4b0e91a03c4c997:69ffa73cb6d78a30405505ddFallon et al, J Virol 2026

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]]>Protective human antibodies against Powassan virusStructural Dynamics and Allosteric Communication of a SARS-Like Bat Coronavirus Spike GlycoproteinKartik ChandranWed, 22 Apr 2026 16:00:00 +0000/balogun202654629d11e4b03a44d1209d37:565b5ed8e4b0e91a03c4c997:69f73bdcfcb0a60006debb5bBalogun et al, Biophys J 2026

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]]>Structural Dynamics and Allosteric Communication of a SARS-Like Bat Coronavirus Spike GlycoproteinHigh-resolution in situ structures of hantavirus glycoprotein tetramersKartik ChandranFri, 27 Feb 2026 17:00:00 +0000/guo202654629d11e4b03a44d1209d37:565b5ed8e4b0e91a03c4c997:69b5777ea20327003feba853Guo et al, Cell 2026

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]]>High-resolution in situ structures of hantavirus glycoprotein tetramersRASP: rapid antibody functional screening by pentavalent phage displayKartik ChandranMon, 09 Feb 2026 17:00:00 +0000/kaur202654629d11e4b03a44d1209d37:565b5ed8e4b0e91a03c4c997:69b573fae7717d6d17f3029fKaur et al, mAbs 2026

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]]>RASP: rapid antibody functional screening by pentavalent phage displayCross-binding antibodies capable of neutralising diverse hantaviruses are produced in response to Puumala virus infectionKartik ChandranThu, 08 Jan 2026 17:00:00 +0000/clark202654629d11e4b03a44d1209d37:565b5ed8e4b0e91a03c4c997:6962b173b7c9007504f905c7Clark et al, EBiomedicine 2026

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]]>Cross-binding antibodies capable of neutralising diverse hantaviruses are produced in response to Puumala virus infectionNanoparticle Adjuvant Design Enhances Germinal Center Responses Targeting Conserved Subdominant Epitopes for Pan-Coronavirus Vaccine DevelopmentKartik ChandranWed, 10 Dec 2025 17:00:00 +0000/huang202554629d11e4b03a44d1209d37:565b5ed8e4b0e91a03c4c997:696049050219282fa845e020Huang et al, Adv Sci (Weinh) 2025

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]]>Nanoparticle Adjuvant Design Enhances Germinal Center Responses Targeting Conserved Subdominant Epitopes for Pan-Coronavirus Vaccine DevelopmentBat sarbecovirus WIV1-CoV bears an adaptive mutation that alters spike dynamics and enhances ACE2 bindingKartik ChandranThu, 16 Oct 2025 16:00:00 +0000/tse202554629d11e4b03a44d1209d37:565b5ed8e4b0e91a03c4c997:68ecc686aab6276768d5ba5aTse et al, PLoS Pathog 2025

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]]>Bat sarbecovirus WIV1-CoV bears an adaptive mutation that alters spike dynamics and enhances ACE2 bindingLRP8 is a receptor for tick-borne encephalitis virusKartik ChandranWed, 24 Sep 2025 15:00:00 +0000/mittler202554629d11e4b03a44d1209d37:565b5ed8e4b0e91a03c4c997:68e13a62c1392120dfd6f3e7Mittler et al, Nature 2025

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]]>LRP8 is a receptor for tick-borne encephalitis virusInfluence of CCL2-mediated modulation of ALIX in the budding and replication of viruses from multiple familiesKartik ChandranTue, 23 Sep 2025 16:00:00 +0000/mofed202554629d11e4b03a44d1209d37:565b5ed8e4b0e91a03c4c997:68e5d0ad3431bd6f12a8682eMofed et al, mBio 2025

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]]>Influence of CCL2-mediated modulation of ALIX in the budding and replication of viruses from multiple familiesAvidity and variable domain spacing strongly influence the therapeutic potency of bispecific antibodies against Crimean-Congo hemorrhagic fever virusKartik ChandranWed, 14 May 2025 16:00:00 +0000/wang202554629d11e4b03a44d1209d37:565b5ed8e4b0e91a03c4c997:6895e9fee35aa02c1d89fd84Wang et al, mBio 2025

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]]>Avidity and variable domain spacing strongly influence the therapeutic potency of bispecific antibodies against Crimean-Congo hemorrhagic fever virusSuFEx-enabled high-throughput medicinal chemistry for developing potent tamoxifen analogs as Ebola virus entry inhibitors (Copy)Kartik ChandranSun, 27 Apr 2025 16:00:00 +0000/dada202554629d11e4b03a44d1209d37:565b5ed8e4b0e91a03c4c997:6895eb0312268851070ca116Dada et al, Front Immunol 2025

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]]>SuFEx-enabled high-throughput medicinal chemistry for developing potent tamoxifen analogs as Ebola virus entry inhibitors (Copy)Antibodies targeting Crimean-Congo hemorrhagic fever virus GP38 limit vascular leak and viral spreadKartik ChandranWed, 19 Feb 2025 17:00:00 +0000/pahmeier202554629d11e4b03a44d1209d37:565b5ed8e4b0e91a03c4c997:67db0f520a71a348cf70ad9dPahmeier et al, Science Transl Med 2025

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]]>Antibodies targeting Crimean-Congo hemorrhagic fever virus GP38 limit vascular leak and viral spreadStructural insights into tecovirimat antiviral activity and poxvirus resistanceKartik ChandranWed, 12 Feb 2025 17:00:00 +0000/vernuccio202554629d11e4b03a44d1209d37:565b5ed8e4b0e91a03c4c997:67db0a695a8bc72d7e3d21b8Vernuccio et al, Nat Microbiol 2025

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]]>Structural insights into tecovirimat antiviral activity and poxvirus resistanceEngineering and structures of Crimean-Congo hemorrhagic fever virus glycoprotein complexesKartik ChandranThu, 23 Jan 2025 17:00:00 +0000/mcfadden202454629d11e4b03a44d1209d37:565b5ed8e4b0e91a03c4c997:6789018934b62b1a24c6e33fMcFadden et al, Cell 2025

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]]>Engineering and structures of Crimean-Congo hemorrhagic fever virus glycoprotein complexesDecoding the blueprint of receptor binding by filoviruses through large-scale binding assays and machine learningKartik ChandranWed, 15 Jan 2025 17:00:00 +0000/lasso202554629d11e4b03a44d1209d37:565b5ed8e4b0e91a03c4c997:6789039069c37f40f710acc0Lasso et al, Cell Host & Microbe 2025

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]]>Decoding the blueprint of receptor binding by filoviruses through large-scale binding assays and machine learningDistinct pathways for evolution of enhanced receptor binding and cell entry in SARS-like bat coronavirusesKartik ChandranFri, 15 Nov 2024 17:00:00 +0000/tse202454629d11e4b03a44d1209d37:565b5ed8e4b0e91a03c4c997:673935e4078cc50796b95552Tse et al, PLoS Pathog. 2024

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]]>Distinct pathways for evolution of enhanced receptor binding and cell entry in SARS-like bat coronaviruses