Stem Cell

materials@nature contents: 22 April 2010

2010-04-22T10:15:00.001-07:00

*********************************
materials@nature.com
*********************************

WOULD YOU PREFER TO RECEIVE THIS ALERT IN HTML FORMAT?
Tell us at http://links.ealert.nature.com/ctt?kn=97&m=34812055&r=MTc2MzU1NDQxMAS2&b=2&j=NzI0NDU4NTMS1&mt=1&rt=0

*********************************************************************
Bringing you the latest and best in materials news and research from
Nature Publishing Group

For more information, see each journal's latest table of contents:

Nature Volume 464 Number 7292 pp1103-1238
http://links.ealert.nature.com/ctt?kn=102&m=34812055&r=MTc2MzU1NDQxMAS2&b=2&j=NzI0NDU4NTMS1&mt=1&rt=0

Nature Materials Volume 9 Number 4 pp281-368
http://links.ealert.nature.com/ctt?kn=148&m=34812055&r=MTc2MzU1NDQxMAS2&b=2&j=NzI0NDU4NTMS1&mt=1&rt=0

Nature Nanotechnology Volume 5 No 4 pp237-309
http://links.ealert.nature.com/ctt?kn=43&m=34812055&r=MTc2MzU1NDQxMAS2&b=2&j=NzI0NDU4NTMS1&mt=1&rt=0

Nature Physics Volume 6 Number 4 pp231-316
http://links.ealert.nature.com/ctt?kn=151&m=34812055&r=MTc2MzU1NDQxMAS2&b=2&j=NzI0NDU4NTMS1&mt=1&rt=0

========================= Advertisement ==========================

Nature Communications - Now Live!

Nature Communications is a new online-only, multidisciplinary journal
with open access options. Dedicated to publishing high quality primary
research in all areas of the biological, physical and chemical
sciences, articles represent important advances of significance to
specialists within each field.

To celebrate the launch, ALL articles are available to access FREE* at
http://links.ealert.nature.com/ctt?kn=17&m=34812055&r=MTc2MzU1NDQxMAS2&b=2&j=NzI0NDU4NTMS1&mt=1&rt=0

*Free access to subscribed-access manuscripts is available until
September 30th, 2010.

=====================================================================

-------------------------------
Editorial
-------------------------------

The weight of evidence
http://links.ealert.nature.com/ctt?kn=114&m=34812055&r=MTc2MzU1NDQxMAS2&b=2&j=NzI0NDU4NTMS1&mt=1&rt=0

-------------------------------
News Feature
-------------------------------

Toxicology: The big test for bisphenol A
http://links.ealert.nature.com/ctt?kn=133&m=34812055&r=MTc2MzU1NDQxMAS2&b=2&j=NzI0NDU4NTMS1&mt=1&rt=0

-------------------------------
News and views
-------------------------------

Materials science: A cloak of liquidity
http://links.ealert.nature.com/ctt?kn=113&m=34812055&r=MTc2MzU1NDQxMAS2&b=2&j=NzI0NDU4NTMS1&mt=1&rt=0

-------------------------------
Letters
-------------------------------

Substrate-enhanced supercooling in AuSi eutectic droplets
T. U. Sch�lli, R. Daudin, G. Renaud, A. Vaysset, O. Geaymond
& A. Pasturel
http://links.ealert.nature.com/ctt?kn=112&m=34812055&r=MTc2MzU1NDQxMAS2&b=2&j=NzI0NDU4NTMS1&mt=1&rt=0

Super-resolution biomolecular crystallography with low-resolution data
Gunnar F. Schr�der, Michael Levitt & Axel T. Brunger
http://links.ealert.nature.com/ctt?kn=109&m=34812055&r=MTc2MzU1NDQxMAS2&b=2&j=NzI0NDU4NTMS1&mt=1&rt=0

A single-layer wide-angle negative-index metamaterial at visible
frequencies
Stanley P. Burgos, Rene de Waele, Albert Polman & Harry A. Atwater
http://links.ealert.nature.com/ctt?kn=146&m=34812055&r=MTc2MzU1NDQxMAS2&b=2&j=NzI0NDU4NTMS1&mt=1&rt=0

Complementary resistive switches for passive nanocrossbar memories
Eike Linn, Roland Rosezin, Carsten K�geler & Rainer Waser
http://links.ealert.nature.com/ctt?kn=21&m=34812055&r=MTc2MzU1NDQxMAS2&b=2&j=NzI0NDU4NTMS1&mt=1&rt=0

Understanding amyloid aggregation by statistical analysis of atomic
force microscopy images
Jozef Adamcik, Jin-Mi Jung, J�r�me Flakowski, Paolo De Los Rios,
Giovanni Dietler & Raffaele Mezzenga
http://links.ealert.nature.com/ctt?kn=48&m=34812055&r=MTc2MzU1NDQxMAS2&b=2&j=NzI0NDU4NTMS1&mt=1&rt=0

Observation and control of blinking nitrogen-vacancy centres in
discrete nanodiamonds
C. Bradac et al.
http://links.ealert.nature.com/ctt?kn=47&m=34812055&r=MTc2MzU1NDQxMAS2&b=2&j=NzI0NDU4NTMS1&mt=1&rt=0

Biologically templated photocatalytic nanostructures for sustained
light-driven water oxidation
Yoon Sung Nam et al.
http://links.ealert.nature.com/ctt?kn=51&m=34812055&r=MTc2MzU1NDQxMAS2&b=2&j=NzI0NDU4NTMS1&mt=1&rt=0

Integrated elastomeric components for autonomous regulation of sequential
and oscillatory flow switching in microfluidic devices
Bobak Mosadegh et al.
http://links.ealert.nature.com/ctt?kn=152&m=34812055&r=MTc2MzU1NDQxMAS2&b=2&j=NzI0NDU4NTMS1&mt=1&rt=0

-------------------------------
Articles
-------------------------------

The thermodynamic origin of hysteresis in insertion batteries
Wolfgang Dreyer, Janko Jamnik, Clemens Guhlke, Robert Huth, Joze Moskon
& Miran Gaberscek
http://links.ealert.nature.com/ctt?kn=20&m=34812055&r=MTc2MzU1NDQxMAS2&b=2&j=NzI0NDU4NTMS1&mt=1&rt=0

Free-floating ultrathin two-dimensional crystals from sequence-specific
peptoid polymers
Ki Tae Nam et al.
http://links.ealert.nature.com/ctt?kn=23&m=34812055&r=MTc2MzU1NDQxMAS2&b=2&j=NzI0NDU4NTMS1&mt=1&rt=0

Dissolvable films of silk fibroin for ultrathin conformal
bio-integrated electronics
Dae-Hyeong Kim et al.
http://links.ealert.nature.com/ctt?kn=22&m=34812055&r=MTc2MzU1NDQxMAS2&b=2&j=NzI0NDU4NTMS1&mt=1&rt=0

State-selective dissociation of a single water molecule on an ultrathin
MgO film
Hyung-Joon Shin et al.
http://links.ealert.nature.com/ctt?kn=24&m=34812055&r=MTc2MzU1NDQxMAS2&b=2&j=NzI0NDU4NTMS1&mt=1&rt=0

Tuning payload delivery in tumour cylindroids using gold nanoparticles
Byoungjin Kim, Gang Han, Bhushan J. Toley, Chae-kyu Kim, Vincent M. Rotello
& Neil S. Forbes
http://links.ealert.nature.com/ctt?kn=50&m=34812055&r=MTc2MzU1NDQxMAS2&b=2&j=NzI0NDU4NTMS1&mt=1&rt=0

A double-stranded DNA rotaxane
Damian Ackermann, Thorsten L. Schmidt, Jeffrey S. Hannam,
Chandra S. Purohit, Alexander Heckel & Michael Famulok
http://links.ealert.nature.com/ctt?kn=53&m=34812055&r=MTc2MzU1NDQxMAS2&b=2&j=NzI0NDU4NTMS1&mt=1&rt=0

Logic implementations using a single nanoparticle?protein hybrid
Izhar Medalsy et al.
http://links.ealert.nature.com/ctt?kn=52&m=34812055&r=MTc2MzU1NDQxMAS2&b=2&j=NzI0NDU4NTMS1&mt=1&rt=0

========================= Advertisement ==========================

Subscribe to Nature Materials, all that matters in material science
and technology, here http://links.ealert.nature.com/ctt?kn=12&m=34812055&r=MTc2MzU1NDQxMAS2&b=2&j=NzI0NDU4NTMS1&mt=1&rt=0

=====================================================================

You have been sent this Table of Contents Alert because you have
opted in to receive it. You can change or discontinue your e-mail
alerts at any time, by modifying your preferences on your
nature.com account at: http://links.ealert.nature.com/ctt?kn=138&m=34812055&r=MTc2MzU1NDQxMAS2&b=2&j=NzI0NDU4NTMS1&mt=1&rt=0
(You will need to log in to be recognised as a nature.com registrant)

For further technical assistance, please contact our registration
department: mailto:registration@nature.com

For print subscription enquiries, please contact our subscription
department: mailto:subscriptions@nature.com

For other enquiries, please contact our customer feedback department:
mailto:feedback@nature.com

Nature Publishing Group * 75 Varick Street, 9th floor * New York *
NY 10013-1917 * USA

Nature Publishing Group's worldwide offices:
London - Paris - Munich - New Delhi - Tokyo - Melbourne
San Diego - San Francisco - Washington - New York - Boston

=====================================================================

Oncogene - Table of Contents alert Volume 29 Issue 16

2010-04-22T09:16:00.001-07:00

ONCOGENE

April 2010 Volume 29 Number 16, pp 2309 - 2456

-----------------------------------------------------------------------
Nature Communications - Now Live!

Nature Communications is a new online-only, multidisciplinary journal
with open access options. Dedicated to publishing high quality primary
research in all areas of the biological, physical and chemical sciences,
articles represent important advances of significance to specialists
within each field.

To celebrate the launch, ALL articles are available to access FREE* at
http://links.ealert.nature.com/ctt?kn=13&m=34811813&r=MTc2ODI0Mjc1MwS2&b=2&j=NzI0NDMxNDES1&mt=1&rt=0

*Free access to subscribed-access manuscripts is available until
September 30th, 2010.

----------------------
REVIEW
----------------------
Viral hepatocarcinogenesis
W-L Tsai and R T Chung
Abstract: http://links.ealert.nature.com/ctt?kn=49&m=34811813&r=MTc2ODI0Mjc1MwS2&b=2&j=NzI0NDMxNDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=64&m=34811813&r=MTc2ODI0Mjc1MwS2&b=2&j=NzI0NDMxNDES1&mt=1&rt=0

----------------------
ORIGINAL ARTICLES
----------------------
AT7519, A novel small molecule multi-cyclin-dependent kinase inhibitor,
induces apoptosis in multiple myeloma via GSK-3[beta] activation and
RNA polymerase II inhibition
L Santo, S Vallet, T Hideshima, D Cirstea, H Ikeda, S Pozzi, K Patel,
Y Okawa, G Gorgun, G Perrone, E Calabrese, M Yule, M Squires, M Ladetto,
M Boccadoro, P G Richardson, N C Munshi, K C Anderson and N Raje
Abstract: http://links.ealert.nature.com/ctt?kn=67&m=34811813&r=MTc2ODI0Mjc1MwS2&b=2&j=NzI0NDMxNDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=60&m=34811813&r=MTc2ODI0Mjc1MwS2&b=2&j=NzI0NDMxNDES1&mt=1&rt=0

Knock in of the AKT1 E17K mutation in human breast epithelial cells does
not recapitulate oncogenic PIK3CA mutations
J Lauring, D P Cosgrove, S Fontana, J P Gustin, H Konishi, A M Abukhdeir,
J P Garay, M Mohseni, G M Wang, M J Higgins, D Gorkin, M Reis, B Vogelstein,
K Polyak, M Cowherd, P J Buckhaults and B H Park
Abstract: http://links.ealert.nature.com/ctt?kn=62&m=34811813&r=MTc2ODI0Mjc1MwS2&b=2&j=NzI0NDMxNDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=58&m=34811813&r=MTc2ODI0Mjc1MwS2&b=2&j=NzI0NDMxNDES1&mt=1&rt=0

Amplification of EGFR T790M causes resistance to an irreversible EGFR
inhibitor
D Ercan, K Zejnullahu, K Yonesaka, Y Xiao, M Capelletti, A Rogers,
E Lifshits, A Brown, C Lee, J G Christensen, D J Kwiatkowski,
J A Engelman and P A Janne
Abstract: http://links.ealert.nature.com/ctt?kn=59&m=34811813&r=MTc2ODI0Mjc1MwS2&b=2&j=NzI0NDMxNDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=54&m=34811813&r=MTc2ODI0Mjc1MwS2&b=2&j=NzI0NDMxNDES1&mt=1&rt=0

Lysine methylation regulates the pRb tumour suppressor protein
S Munro, N Khaire, A Inche, S Carr and N B La Thangue
Abstract: http://links.ealert.nature.com/ctt?kn=55&m=34811813&r=MTc2ODI0Mjc1MwS2&b=2&j=NzI0NDMxNDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=68&m=34811813&r=MTc2ODI0Mjc1MwS2&b=2&j=NzI0NDMxNDES1&mt=1&rt=0

Extracellular matrix-induced transforming growth factor-[beta] receptor
signaling dynamics
N Garamszegi, S P Garamszegi, P Samavarchi-Tehrani, E Walford,
M M Schneiderbauer, J L Wrana and S P Scully
Abstract: http://links.ealert.nature.com/ctt?kn=20&m=34811813&r=MTc2ODI0Mjc1MwS2&b=2&j=NzI0NDMxNDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=21&m=34811813&r=MTc2ODI0Mjc1MwS2&b=2&j=NzI0NDMxNDES1&mt=1&rt=0

Peptide-based interference of the transmembrane domain of neuropilin-1
inhibits glioma growth in vivo
C Nasarre, M Roth, L Jacob, L Roth, E Koncina, A Thien, G Labourdette,
P Poulet, P Hubert, G Cremel, G Roussel, D Aunis and D Bagnard
Abstract: http://links.ealert.nature.com/ctt?kn=22&m=34811813&r=MTc2ODI0Mjc1MwS2&b=2&j=NzI0NDMxNDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=23&m=34811813&r=MTc2ODI0Mjc1MwS2&b=2&j=NzI0NDMxNDES1&mt=1&rt=0

ASAP1 promotes tumor cell motility and invasiveness, stimulates metastasis
formation in vivo, and correlates with poor survival in colorectal cancer
patients
T Muller, U Stein, A Poletti, L Garzia, M Rothley, D Plaumann, W Thiele,
M Bauer, A Galasso, P Schlag, M Pankratz, M Zollo and J P Sleeman
Abstract: http://links.ealert.nature.com/ctt?kn=24&m=34811813&r=MTc2ODI0Mjc1MwS2&b=2&j=NzI0NDMxNDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=25&m=34811813&r=MTc2ODI0Mjc1MwS2&b=2&j=NzI0NDMxNDES1&mt=1&rt=0

Phosphorylation of the mutant K303R estrogen receptor [alpha] at serine
305 affects aromatase inhibitor sensitivity
I Barone, D Iacopetta, K R Covington, Y Cui, A Tsimelzon, A Beyer,
S Ando and S A W Fuqua
Abstract: http://links.ealert.nature.com/ctt?kn=26&m=34811813&r=MTc2ODI0Mjc1MwS2&b=2&j=NzI0NDMxNDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=27&m=34811813&r=MTc2ODI0Mjc1MwS2&b=2&j=NzI0NDMxNDES1&mt=1&rt=0

Role of Mdm4 in drug sensitivity of breast cancer cells
S Lam, K Lodder, A F A S Teunisse, M J W E Rabelink, M Schutte and
A G Jochemsen
Abstract: http://links.ealert.nature.com/ctt?kn=29&m=34811813&r=MTc2ODI0Mjc1MwS2&b=2&j=NzI0NDMxNDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=32&m=34811813&r=MTc2ODI0Mjc1MwS2&b=2&j=NzI0NDMxNDES1&mt=1&rt=0

Cadherin switching and activation of p120 catenin signaling are mediators
of gonadotropin-releasing hormone to promote tumor cell migration and
invasion in ovarian cancer
L W T Cheung, P C K Leung and A S T Wong
Abstract: http://links.ealert.nature.com/ctt?kn=40&m=34811813&r=MTc2ODI0Mjc1MwS2&b=2&j=NzI0NDMxNDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=5&m=34811813&r=MTc2ODI0Mjc1MwS2&b=2&j=NzI0NDMxNDES1&mt=1&rt=0

----------------------
SHORT COMMUNICATIONS
----------------------
Formin-like 2 drives amoeboid invasive cell motility downstream of RhoC
T M Kitzing, Y Wang, O Pertz, J W Copeland and R Grosse
Abstract: http://links.ealert.nature.com/ctt?kn=6&m=34811813&r=MTc2ODI0Mjc1MwS2&b=2&j=NzI0NDMxNDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=1&m=34811813&r=MTc2ODI0Mjc1MwS2&b=2&j=NzI0NDMxNDES1&mt=1&rt=0

Dissection of RAS downstream pathways in melanomagenesis: a role for Ral
in transformation
P J Mishra, L Ha, J Rieker, E V Sviderskaya, D C Bennett, M D Oberst,
K Kelly and G Merlino
Abstract: http://links.ealert.nature.com/ctt?kn=3&m=34811813&r=MTc2ODI0Mjc1MwS2&b=2&j=NzI0NDMxNDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=8&m=34811813&r=MTc2ODI0Mjc1MwS2&b=2&j=NzI0NDMxNDES1&mt=1&rt=0

-----------------------------------------------------------------------
Ensure your access

If you are unable to access the articles in this Table of Contents e-alert,
your library may not subscribe to this journal. Our online recommendation
form is a simple way to make your librarian aware that this journal is
valuable to your research.

Recommend now at
http://links.ealert.nature.com/ctt?kn=69&m=34811813&r=MTc2ODI0Mjc1MwS2&b=2&j=NzI0NDMxNDES1&mt=1&rt=0

=====================================================================

You have been sent this Table of Contents Alert because you have opted
in to receive it. You can change or discontinue your e-mail alerts at
any time, by modifying your preferences on your nature.com account at:
http://links.ealert.nature.com/ctt?kn=47&m=34811813&r=MTc2ODI0Mjc1MwS2&b=2&j=NzI0NDMxNDES1&mt=1&rt=0
(You will need to log in to be recognised as a nature.com registrant).

For further technical assistance, please contact our registration
department: registration@nature.com

For print subscription enquiries, please contact our subscription
department: subscriptions@nature.com

For other enquiries, please contact customer feedback department:
feedback@nature.com

Nature Publishing Group | 75 Varick Street, 9th Floor | New York | NY 10013-1917 | USA

Nature Publishing Group's worldwide offices:
London - Paris - Munich - New Delhi - Tokyo - Melbourne - San Diego - San Francisco - Washington - New York - Boston

Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at Brunel Road, Houndmills, Basingstoke, Hampshire RG21 6XS.

=====================================================================

Genes and Immunity - Table of Contents alert Volume 11 Issue 3

2010-04-22T07:16:00.001-07:00

GENES AND IMMUNITY

April 2010 Volume 11 Number 3, pp 199 - 278

=====================================================================

Mucosal Immunology
The official publication of the Society for Mucosal Immunology (SMI)
Indexed by Medline
Mucosal Immunology presents
A focus on the latest developments in understanding allergic disease

This issue brings together reviews on immune activation by allergens,
the role of basophils in driving Th2 immunity, the function of epithelial
cytokines such as TSLP in allergic inflammatory responses, and advances
in understanding Mast cell phenotypes and functions.

http://links.ealert.nature.com/ctt?kn=7&m=34811114&r=MTc2MTE2NTAwMwS2&b=2&j=NzI0MzcxMzkS1&mt=1&rt=0

=====================================================================
----------------------
ORIGINAL ARTICLES
----------------------
Supervised machine learning and logistic regression identifies novel
epistatic risk factors with PTPN22 for rheumatoid arthritis
F B S Briggs, P P Ramsay, E Madden, J M Norris, V M Holers,
T R Mikuls, T Sokka, M F Seldin, P K Gregersen, L A Criswell
and L F Barcellos
Abstract: http://links.ealert.nature.com/ctt?kn=18&m=34811114&r=MTc2MTE2NTAwMwS2&b=2&j=NzI0MzcxMzkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=24&m=34811114&r=MTc2MTE2NTAwMwS2&b=2&j=NzI0MzcxMzkS1&mt=1&rt=0

Genetic variation within the HLA class III influences T1D
susceptibility conferred by high-risk HLA haplotypes
A M Valdes, G Thomson and L F Barcellos the T1DGC
Abstract: http://links.ealert.nature.com/ctt?kn=25&m=34811114&r=MTc2MTE2NTAwMwS2&b=2&j=NzI0MzcxMzkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=17&m=34811114&r=MTc2MTE2NTAwMwS2&b=2&j=NzI0MzcxMzkS1&mt=1&rt=0

Quantitative lymphatic vessel trait analysis suggests Vcam1 as
candidate modifier gene of inflammatory bowel disease
G Jurisic, J P Sundberg, A Bleich, E H Leiter, K W Broman,
G Buechler, L Alley, D Vestweber and M Detmar
Abstract: http://links.ealert.nature.com/ctt?kn=20&m=34811114&r=MTc2MTE2NTAwMwS2&b=2&j=NzI0MzcxMzkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=21&m=34811114&r=MTc2MTE2NTAwMwS2&b=2&j=NzI0MzcxMzkS1&mt=1&rt=0

New genetic associations detected in a host response study to
hepatitis B vaccine
S Davila, F E M Froeling, A Tan, C Bonnard, G J Boland, H Snippe,
M L Hibberd and M Seielstad
Abstract: http://links.ealert.nature.com/ctt?kn=22&m=34811114&r=MTc2MTE2NTAwMwS2&b=2&j=NzI0MzcxMzkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=26&m=34811114&r=MTc2MTE2NTAwMwS2&b=2&j=NzI0MzcxMzkS1&mt=1&rt=0

Finemapping of the arthritis QTL Pia7 reveals co-localization with
Oia2 and the APLEC locus
C Rintisch, T Kelkka, U Norin, J C Lorentzen, P Olofsson and
R Holmdahl
Abstract: http://links.ealert.nature.com/ctt?kn=27&m=34811114&r=MTc2MTE2NTAwMwS2&b=2&j=NzI0MzcxMzkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=28&m=34811114&r=MTc2MTE2NTAwMwS2&b=2&j=NzI0MzcxMzkS1&mt=1&rt=0

Involvement of T-cell receptor-[beta] alterations in the development
of otosclerosis linked to OTSC2
I Schrauwen, K Venken, K Vanderstraeten, M Thys, J-J Hendrickx,
E Fransen, L Van Laer, P J Govaerts, M Verstreken, I Schatteman,
P Stinissen, N Hellings and G Van Camp
Abstract: http://links.ealert.nature.com/ctt?kn=37&m=34811114&r=MTc2MTE2NTAwMwS2&b=2&j=NzI0MzcxMzkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=38&m=34811114&r=MTc2MTE2NTAwMwS2&b=2&j=NzI0MzcxMzkS1&mt=1&rt=0

Immunoglobulin heavy chain variable region genes contribute to the
induction of thyroid-stimulating antibodies in recombinant inbred mice
B Rapoport, R W Williams, C-R Chen and S M McLachlan
Abstract: http://links.ealert.nature.com/ctt?kn=32&m=34811114&r=MTc2MTE2NTAwMwS2&b=2&j=NzI0MzcxMzkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=31&m=34811114&r=MTc2MTE2NTAwMwS2&b=2&j=NzI0MzcxMzkS1&mt=1&rt=0

STAT3 locus in inflammatory bowel disease and multiple
sclerosis susceptibility
M C Cenit, A Alcina, A Marquez, J L Mendoza, M Diaz-Rubio,
V de las Heras, G Izquierdo, R Arroyo, O Fernandez, E G de la Concha,
F Matesanz and E Urcelay
Abstract: http://links.ealert.nature.com/ctt?kn=30&m=34811114&r=MTc2MTE2NTAwMwS2&b=2&j=NzI0MzcxMzkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=29&m=34811114&r=MTc2MTE2NTAwMwS2&b=2&j=NzI0MzcxMzkS1&mt=1&rt=0

Specific gene expression signature associated with development of
autoimmune type-I diabetes using whole-blood microarray analysis
F Reynier, A Pachot, M Paye, Q Xu, F Turrel-Davin, F Petit, A Hot,
C Auffray, N Bendelac, M Nicolino, B Mougin and C Thivolet
Abstract: http://links.ealert.nature.com/ctt?kn=35&m=34811114&r=MTc2MTE2NTAwMwS2&b=2&j=NzI0MzcxMzkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=33&m=34811114&r=MTc2MTE2NTAwMwS2&b=2&j=NzI0MzcxMzkS1&mt=1&rt=0

=====================================================================

Nature Communications - Now Live!

Nature Communications is a new online-only, multidisciplinary journal
with open access options. Dedicated to publishing high quality primary
research in all areas of the biological, physical and chemical sciences,
articles represent important advances of significance to specialists
within each field.

To celebrate the launch, ALL articles are available to access FREE* at
http://links.ealert.nature.com/ctt?kn=3&m=34811114&r=MTc2MTE2NTAwMwS2&b=2&j=NzI0MzcxMzkS1&mt=1&rt=0

*Free access to subscribed-access manuscripts is available until September 30th, 2010.

=====================================================================

You have been sent this Table of Contents Alert because you have
opted in to receive it.
You can change or discontinue your e-mail alerts at any time, by
modifying your preferences on your nature.com account at:
http://links.ealert.nature.com/ctt?kn=41&m=34811114&r=MTc2MTE2NTAwMwS2&b=2&j=NzI0MzcxMzkS1&mt=1&rt=0
(You will need to log in to be recognised as a nature.com
registrant).

For further technical assistance, please contact our registration
department:
registration@nature.com

For print subscription enquiries, please contact our subscription
department:
subscriptions@nature.com

For other enquiries, please contact customer feedback department:
feedback@nature.com

Nature Publishing Group | 75 Varick Street, 9th Floor | New York
| NY 10013-1917 | USA

Nature Publishing Group's worldwide offices:
London - Paris - Munich - New Delhi - Tokyo - Melbourne - San Diego
- San Francisco - Washington - New York - Boston

Macmillan Publishers Limited is a company incorporated in England
and Wales under company number 785998 and whose registered office
is located at Brunel Road, Houndmills, Basingstoke, Hampshire
RG21 6XS.

=====================================================================

physics@nature.com 22 April 2010

2010-04-22T06:33:00.001-07:00

*********************************
physics@nature.com
*********************************

WOULD YOU PREFER TO RECEIVE THIS ALERT IN HTML FORMAT?
Tell us at http://links.ealert.nature.com/ctt?kn=85&m=34810841&r=MTc2ODM1MzAwNQS2&b=2&j=NzI0MzQ2ODMS1&mt=1&rt=0

*********************************************************************
Bringing you the latest and best in physics news and research from
Nature Publishing Group

For more information, see each journal's latest table of contents:

Nature Volume 464 Number 7292 pp 1103-1238
http://links.ealert.nature.com/ctt?kn=11&m=34810841&r=MTc2ODM1MzAwNQS2&b=2&j=NzI0MzQ2ODMS1&mt=1&rt=0

Nature Physics Volume 6 Number 4 pp 231-316
http://links.ealert.nature.com/ctt?kn=50&m=34810841&r=MTc2ODM1MzAwNQS2&b=2&j=NzI0MzQ2ODMS1&mt=1&rt=0

Nature Materials Volume 9 Number 4 pp 281-368
http://links.ealert.nature.com/ctt?kn=117&m=34810841&r=MTc2ODM1MzAwNQS2&b=2&j=NzI0MzQ2ODMS1&mt=1&rt=0

Nature Nanotechnology Volume 5 Number 4 pp 237-309
http://links.ealert.nature.com/ctt?kn=47&m=34810841&r=MTc2ODM1MzAwNQS2&b=2&j=NzI0MzQ2ODMS1&mt=1&rt=0

Nature Photonics Volume 4 Number 4 pp 195-258
http://links.ealert.nature.com/ctt?kn=97&m=34810841&r=MTc2ODM1MzAwNQS2&b=2&j=NzI0MzQ2ODMS1&mt=1&rt=0

=========================== ADVERTISEMENT ===========================

Subscribe to Nature Physics for top quality research in all areas of
pure and applied physics here
http://links.ealert.nature.com/ctt?kn=95&m=34810841&r=MTc2ODM1MzAwNQS2&b=2&j=NzI0MzQ2ODMS1&mt=1&rt=0

======================================================================

-------------------------------
Editorial
-------------------------------

Nuclear ambition
http://links.ealert.nature.com/ctt?kn=79&m=34810841&r=MTc2ODM1MzAwNQS2&b=2&j=NzI0MzQ2ODMS1&mt=1&rt=0

-------------------------------
News
-------------------------------

Scientists measure atomic nudge
http://links.ealert.nature.com/ctt?kn=116&m=34810841&r=MTc2ODM1MzAwNQS2&b=2&j=NzI0MzQ2ODMS1&mt=1&rt=0

-------------------------------
News and Views
-------------------------------

Quantum measurement: A condensate's main squeeze
http://links.ealert.nature.com/ctt?kn=64&m=34810841&r=MTc2ODM1MzAwNQS2&b=2&j=NzI0MzQ2ODMS1&mt=1&rt=0

-------------------------------
Letters
-------------------------------

Possible thermochemical disequilibrium in the atmosphere of the
exoplanet GJ 436b
Kevin B. Stevenson et al.
http://links.ealert.nature.com/ctt?kn=46&m=34810841&r=MTc2ODM1MzAwNQS2&b=2&j=NzI0MzQ2ODMS1&mt=1&rt=0

Nonlinear atom interferometer surpasses classical precision limit
C. Gross et al.
http://links.ealert.nature.com/ctt?kn=41&m=34810841&r=MTc2ODM1MzAwNQS2&b=2&j=NzI0MzQ2ODMS1&mt=1&rt=0

Atom-chip-based generation of entanglement for quantum metrology
Max F. Riedel et al.
http://links.ealert.nature.com/ctt?kn=39&m=34810841&r=MTc2ODM1MzAwNQS2&b=2&j=NzI0MzQ2ODMS1&mt=1&rt=0

Integrated elastomeric components for autonomous regulation of
sequential and oscillatory flow switching in microfluidic devices
Bobak Mosadegh et al.
http://links.ealert.nature.com/ctt?kn=142&m=34810841&r=MTc2ODM1MzAwNQS2&b=2&j=NzI0MzQ2ODMS1&mt=1&rt=0

Complementary resistive switches for passive nanocrossbar memories
Eike Linn, Roland Rosezin, Carsten K�geler & Rainer Waser
http://links.ealert.nature.com/ctt?kn=54&m=34810841&r=MTc2ODM1MzAwNQS2&b=2&j=NzI0MzQ2ODMS1&mt=1&rt=0

A single-layer wide-angle negative-index metamaterial at visible
frequencies
Stanley P. Burgos, Rene de Waele, Albert Polman & Harry A. Atwater
http://links.ealert.nature.com/ctt?kn=102&m=34810841&r=MTc2ODM1MzAwNQS2&b=2&j=NzI0MzQ2ODMS1&mt=1&rt=0

Room-temperature polariton lasing in an organic single-crystal
microcavity
S. Kena-Cohen & S. R. Forrest
http://links.ealert.nature.com/ctt?kn=127&m=34810841&r=MTc2ODM1MzAwNQS2&b=2&j=NzI0MzQ2ODMS1&mt=1&rt=0

Ultrafast optical spin echo in a single quantum dot
David Press et al.
http://links.ealert.nature.com/ctt?kn=130&m=34810841&r=MTc2ODM1MzAwNQS2&b=2&j=NzI0MzQ2ODMS1&mt=1&rt=0

-------------------------------
Articles
-------------------------------

Experimental violation of a Bell's inequality in time with weak
measurement
Agustin Palacios-Laloy et al.
http://links.ealert.nature.com/ctt?kn=138&m=34810841&r=MTc2ODM1MzAwNQS2&b=2&j=NzI0MzQ2ODMS1&mt=1&rt=0

Laser-driven amplification of soft X-rays by parametric stimulated
emission in neutral gases
J. Seres et al.
http://links.ealert.nature.com/ctt?kn=136&m=34810841&r=MTc2ODM1MzAwNQS2&b=2&j=NzI0MzQ2ODMS1&mt=1&rt=0

Dissolvable films of silk fibroin for ultrathin conformal
bio-integrated electronics
Brian Litt and John A. Rogers et al.
http://links.ealert.nature.com/ctt?kn=114&m=34810841&r=MTc2ODM1MzAwNQS2&b=2&j=NzI0MzQ2ODMS1&mt=1&rt=0

Logic implementations using a single nanoparticle-protein hybrid
Izhar Medalsy et al.
http://links.ealert.nature.com/ctt?kn=2&m=34810841&r=MTc2ODM1MzAwNQS2&b=2&j=NzI0MzQ2ODMS1&mt=1&rt=0

Room-temperature subwavelength metallo-dielectric lasers
Maziar P. Nezhad et al.
http://links.ealert.nature.com/ctt?kn=133&m=34810841&r=MTc2ODM1MzAwNQS2&b=2&j=NzI0MzQ2ODMS1&mt=1&rt=0

=========================== ADVERTISEMENT ===========================

Free to view: digital edition of Nature Photonics Technology Focus

Newly available as a digital edition, see for yourself if the Nature
Photonics Technology Focus is right for you. January and March issues
are free to view here
http://links.ealert.nature.com/ctt?kn=48&m=34810841&r=MTc2ODM1MzAwNQS2&b=2&j=NzI0MzQ2ODMS1&mt=1&rt=0

Like what you see. Register here today for your FREE subscription!
http://links.ealert.nature.com/ctt?kn=150&m=34810841&r=MTc2ODM1MzAwNQS2&b=2&j=NzI0MzQ2ODMS1&mt=1&rt=0

=====================================================================

You have been sent this Table of Contents Alert because you have
opted in to receive it. You can change or discontinue your e-mail
alerts at any time, by modifying your preferences on your
nature.com account at: http://links.ealert.nature.com/ctt?kn=93&m=34810841&r=MTc2ODM1MzAwNQS2&b=2&j=NzI0MzQ2ODMS1&mt=1&rt=0
(You will need to log in to be recognised as a nature.com registrant)

For further technical assistance, please contact our registration
department: mailto:registration@nature.com

For print subscription enquiries, please contact our subscription
department: mailto:subscriptions@nature.com

For other enquiries, please contact our customer feedback department:
mailto:feedback@nature.com

Nature Publishing Group * 75 Varick Street, 9th floor * New York *
NY 10013-1917 * USA

Nature Publishing Group's worldwide offices:
London - Paris - Munich - New Delhi - Tokyo - Melbourne
San Diego - San Francisco - Washington - New York - Boston

=====================================================================

The EMBO Journal - Table of Contents alert Volume 29 Issue 8

2010-04-22T02:37:00.000-07:00

THE EMBO JOURNAL

21 April 2010 Volume 29 Number 8, pp 1313 - 1471

Visit The EMBO Journal online to browse the journal.

Now available at http://links.ealert.nature.com/ctt?kn=87&m=34810069&r=MTc2ODY3NTU2NQS2&b=2&j=NzI0MjQ1OTYS1&mt=1&rt=0

Please note that you need to be a subscriber to enjoy full text access to The EMBO Journal online. To purchase a subscription, please visit:
http://links.ealert.nature.com/ctt?kn=54&m=34810069&r=MTc2ODY3NTU2NQS2&b=2&j=NzI0MjQ1OTYS1&mt=1&rt=0

Alternatively, to recommend a subscription to your library, please visit
http://links.ealert.nature.com/ctt?kn=104&m=34810069&r=MTc2ODY3NTU2NQS2&b=2&j=NzI0MjQ1OTYS1&mt=1&rt=0

=========================== ADVERTISEMENT ===========================

Use far less starting material for RNA Labeling while maintaining the
same high sensitivity analysis expected from Agilent gene expression arrays. Just launched - the new Low Input Quick Amp Labeling Kit, allowing you to detect both low- and high-expressors, while you conserve on precious RNA samples. Learn how at www.agilent.com/genomics/low_input_quickamp.

=====================================================================

=========================== ADVERTISEMENT ===========================

The EMBO Meeting 2010 - advancing the life sciences
4-7 September 2010, Barcelona
Featuring:
- Plenary lecture sessions devoted to modern evolutionary biology, molecular developmental biology and the rapidly developing field of systems biology
- 21 workshops juxtapose classical fields of research with those exploring new frontiers in molecular biology
- Daily meet the speaker lunches and poster sessions
- Popular career development activities
For further information, to submit abstracts and to register visit:
www.the-embo-meeting.org

=====================================================================

=========================== ADVERTISEMENT ===========================

Interested in protein translation? Please take a look at this article that recently appeared in EMBO reports:

Sumoylation of eIF4E Activates mRNA Translation

Jing Hu and colleagues

Work by Hu and colleagues shows that mammalian eIF4E is regulated by SUMO-1 conjugation, which promotes the formation of the active eIF4F translation initiation complex and induces the translation of a subset of proteins that are essential for cell proliferation and preventing apoptosis. These results indicate that sumoylation represents a novel fundamental regulation mechanism of protein synthesis.

http://links.ealert.nature.com/ctt?kn=58&m=34810069&r=MTc2ODY3NTU2NQS2&b=2&j=NzI0MjQ1OTYS1&mt=1&rt=0

=====================================================================

----------------------
HAVE YOU SEEN ...?
----------------------
Adaptin' endosomes for synaptic vesicle recycling, learning and memory
Michael Krausz and Volker Haucke
doi:10.1038/emboj.2010.47
Abstract: http://links.ealert.nature.com/ctt?kn=49&m=34810069&r=MTc2ODY3NTU2NQS2&b=2&j=NzI0MjQ1OTYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=45&m=34810069&r=MTc2ODY3NTU2NQS2&b=2&j=NzI0MjQ1OTYS1&mt=1&rt=0

Salmonella vacuole maturation: PIKfyve leads the way
Maximiliano G Gutierrez
doi:10.1038/emboj.2010.41
Abstract: http://links.ealert.nature.com/ctt?kn=46&m=34810069&r=MTc2ODY3NTU2NQS2&b=2&j=NzI0MjQ1OTYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=43&m=34810069&r=MTc2ODY3NTU2NQS2&b=2&j=NzI0MjQ1OTYS1&mt=1&rt=0

----------------------
ARTICLES
----------------------
AP-1/[sigma]1B-adaptin mediates endosomal synaptic vesicle recycling, learning and memory
Nataliya Glyvuk, Yaroslav Tsytsyura, Constanze Geumann, Rudi D'Hooge, Jana Hüve, Manuel Kratzke, Jennifer Baltes, Daniel Böning, Jürgen Klingauf and Peter Schu
doi:10.1038/emboj.2010.15
Abstract: http://links.ealert.nature.com/ctt?kn=44&m=34810069&r=MTc2ODY3NTU2NQS2&b=2&j=NzI0MjQ1OTYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=42&m=34810069&r=MTc2ODY3NTU2NQS2&b=2&j=NzI0MjQ1OTYS1&mt=1&rt=0

Inhibition of the PtdIns(5) kinase PIKfyve disrupts intracellular replication of Salmonella
Markus C Kerr, Jack T H Wang, Natalie A Castro, Nicholas A Hamilton, Liam Town, Darren L Brown, Frederic A Meunier, Nat F Brown, Jennifer L Stow and Rohan D Teasdale
doi:10.1038/emboj.2010.28
Abstract: http://links.ealert.nature.com/ctt?kn=32&m=34810069&r=MTc2ODY3NTU2NQS2&b=2&j=NzI0MjQ1OTYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=31&m=34810069&r=MTc2ODY3NTU2NQS2&b=2&j=NzI0MjQ1OTYS1&mt=1&rt=0

Phosphatidylinositol-(4,5)-bisphosphate enables efficient secretion of HIV-1 Tat by infected T-cells
Fabienne Rayne, Solène Debaisieux, Hocine Yezid, Yea-Lih Lin, Clément Mettling, Karidia Konate, Nathalie Chazal, Stefan T Arold, Martine Pugnière, Françoise Sanchez, Anne Bonhoure, Laurence Briant, Erwann Loret, Christian Roy and Bruno Beaumelle
doi:10.1038/emboj.2010.32
Abstract: http://links.ealert.nature.com/ctt?kn=29&m=34810069&r=MTc2ODY3NTU2NQS2&b=2&j=NzI0MjQ1OTYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=28&m=34810069&r=MTc2ODY3NTU2NQS2&b=2&j=NzI0MjQ1OTYS1&mt=1&rt=0

A bacterial effector targets host DH-PH domain RhoGEFs and antagonizes macrophage phagocytosis
Na Dong, Liping Liu and Feng Shao
doi:10.1038/emboj.2010.33
Abstract: http://links.ealert.nature.com/ctt?kn=36&m=34810069&r=MTc2ODY3NTU2NQS2&b=2&j=NzI0MjQ1OTYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=35&m=34810069&r=MTc2ODY3NTU2NQS2&b=2&j=NzI0MjQ1OTYS1&mt=1&rt=0

VEGF receptor 2/-3 heterodimers detected in situ by proximity ligation on angiogenic sprouts
Ingrid Nilsson, Fuad Bahram, Xiujuan Li, Laura Gualandi, Sina Koch, Malin Jarvius, Ola Söderberg, Andrey Anisimov, Ivana Kholová, Bronislaw Pytowski, Megan Baldwin, Seppo Ylä-Herttuala, Kari Alitalo, Johan Kreuger and Lena Claesson-Welsh
doi:10.1038/emboj.2010.30
Abstract: http://links.ealert.nature.com/ctt?kn=34&m=34810069&r=MTc2ODY3NTU2NQS2&b=2&j=NzI0MjQ1OTYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=33&m=34810069&r=MTc2ODY3NTU2NQS2&b=2&j=NzI0MjQ1OTYS1&mt=1&rt=0

Interaction of MAGED1 with nuclear receptors affects circadian clock function
Xiaohan Wang, Jing Tang, Lijuan Xing, Guangsen Shi, Haibin Ruan, Xiwen Gu, Zhiwei Liu, Xi Wu, Xiang Gao and Ying Xu
doi:10.1038/emboj.2010.34
Abstract: http://links.ealert.nature.com/ctt?kn=38&m=34810069&r=MTc2ODY3NTU2NQS2&b=2&j=NzI0MjQ1OTYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=37&m=34810069&r=MTc2ODY3NTU2NQS2&b=2&j=NzI0MjQ1OTYS1&mt=1&rt=0

UTX mediates demethylation of H3K27me3 at muscle-specific genes during myogenesis
Shayesta Seenundun, Shravanti Rampalli, Qi-Cai Liu, Arif Aziz, Carmen Palii, SunHwa Hong, Alexandre Blais, Marjorie Brand, Kai Ge and Francis Jeffrey Dilworth
doi:10.1038/emboj.2010.37
Abstract: http://links.ealert.nature.com/ctt?kn=39&m=34810069&r=MTc2ODY3NTU2NQS2&b=2&j=NzI0MjQ1OTYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=15&m=34810069&r=MTc2ODY3NTU2NQS2&b=2&j=NzI0MjQ1OTYS1&mt=1&rt=0

Daughter cell separation is controlled by cytokinetic ring-activated cell wall hydrolysis
Tsuyoshi Uehara, Katherine R Parzych, Thuy Dinh and Thomas G Bernhardt
doi:10.1038/emboj.2010.36
Abstract: http://links.ealert.nature.com/ctt?kn=14&m=34810069&r=MTc2ODY3NTU2NQS2&b=2&j=NzI0MjQ1OTYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=17&m=34810069&r=MTc2ODY3NTU2NQS2&b=2&j=NzI0MjQ1OTYS1&mt=1&rt=0

Separating speed and ability to displace roadblocks during DNA translocation by FtsK
Estelle Crozat, Adrien Meglio, Jean-François Allemand, Claire E Chivers, Mark Howarth, Catherine Vénien-Bryan, Ian Grainge and David J Sherratt
doi:10.1038/emboj.2010.29
Abstract: http://links.ealert.nature.com/ctt?kn=16&m=34810069&r=MTc2ODY3NTU2NQS2&b=2&j=NzI0MjQ1OTYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=19&m=34810069&r=MTc2ODY3NTU2NQS2&b=2&j=NzI0MjQ1OTYS1&mt=1&rt=0

A cooperative activation loop among SWI/SNF, [gamma]-H2AX and H3 acetylation for DNA double-strand break repair
Han-Sae Lee, Ji-Hye Park, So-Jung Kim, Su-Jung Kwon and Jongbum Kwon
doi:10.1038/emboj.2010.27
Abstract: http://links.ealert.nature.com/ctt?kn=18&m=34810069&r=MTc2ODY3NTU2NQS2&b=2&j=NzI0MjQ1OTYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=21&m=34810069&r=MTc2ODY3NTU2NQS2&b=2&j=NzI0MjQ1OTYS1&mt=1&rt=0

High-resolution profiling of [gamma]H2AX around DNA double strand breaks in the mammalian genome
Jason S Iacovoni, Pierre Caron, Imen Lassadi, Estelle Nicolas, Laurent Massip, Didier Trouche and Gaëlle Legube
doi:10.1038/emboj.2010.38
Abstract: http://links.ealert.nature.com/ctt?kn=20&m=34810069&r=MTc2ODY3NTU2NQS2&b=2&j=NzI0MjQ1OTYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=22&m=34810069&r=MTc2ODY3NTU2NQS2&b=2&j=NzI0MjQ1OTYS1&mt=1&rt=0

IBRDC2, an IBR-type E3 ubiquitin ligase, is a regulatory factor for Bax and apoptosis activation
Giovanni Benard, Albert Neutzner, Guihong Peng, Chunxin Wang, Ferenc Livak, Richard J Youle and Mariusz Karbowski
doi:10.1038/emboj.2010.39
Abstract: http://links.ealert.nature.com/ctt?kn=26&m=34810069&r=MTc2ODY3NTU2NQS2&b=2&j=NzI0MjQ1OTYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=27&m=34810069&r=MTc2ODY3NTU2NQS2&b=2&j=NzI0MjQ1OTYS1&mt=1&rt=0

=====================================================================

You have been sent this Table of Contents Alert because you have opted in to
receive it. You can change or discontinue your e-mail alerts at any time,
by modifying your preferences on your nature.com account at:
http://links.ealert.nature.com/ctt?kn=24&m=34810069&r=MTc2ODY3NTU2NQS2&b=2&j=NzI0MjQ1OTYS1&mt=1&rt=0
(You will need to log in to be recognised as a nature.com registrant).

For further technical assistance, please contact our registration department:
registration@nature.com

For print subscription enquiries, please contact our subscription department:
subscriptions@nature.com

For other enquiries, please contact our customer feedback department:
feedback@nature.com

Nature Publishing Group | 75 Varick Street, 9th Floor | New York |
NY 10013-1917 | USA

Nature Publishing Group's worldwide offices:
London - Paris - Munich - New Delhi - Tokyo - Melbourne -
San Diego - San Francisco - Washington - New York - Boston

=====================================================================

Nature 22 April 2010 Volume 464 Number 7292 pp1103-1238

2010-04-21T10:56:00.003-07:00

NATURE

22 April 2010 Volume 464 Number 7292, pp 1103 - 1238

Visit Nature online to browse the journal.

Now available at http://links.ealert.nature.com/ctt?kn=199&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

Please note that you need to be a subscriber to enjoy full text access
to Nature online. To purchase a subscription, please visit:
http://links.ealert.nature.com/ctt?kn=86&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

Alternatively, to recommend a subscription to your library, please visit
http://links.ealert.nature.com/ctt?kn=42&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

=========================== ADVERTISEMENT ===========================
A*STAR Research is a free online and print publication highlighting
the best of research at the Agency for Science, Technology and
Research (A*STAR) - Singapore's premier research organization

Latest Highlights:
http://links.ealert.nature.com/ctt?kn=129&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0
* Brain–computer interfaces: Translating brain waves
* Genetics: Colitis research takes guts

Keep up to date by registering for A*Star Research email alerts!
http://links.ealert.nature.com/ctt?kn=22&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0
=====================================================================

=========================== ADVERTISEMENT ===========================
WIN Symposium in personalized cancer medicine
7th-9th July 2010, Palais des Congres, Paris
Presenting breakthrough scientific technologies and achievements in
personalized cancer medicine, with a special focus on individualized
treatment and early diagnosis of cancer.
Register online or download a registration form for this exciting event.
=====================================================================

=========================== ADVERTISEMENT ===========================
Nature Communications - Now Live!

To celebrate the launch, ALL articles are available to access FREE* at
http://links.ealert.nature.com/ctt?kn=200&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

*Free access to subscribed-access manuscripts is available until
September 30th, 2010.
=====================================================================

=========================== ADVERTISEMENT ===========================
Nature News & Views Forum

From April 1st, Nature introduced an occasional variation on the
traditional format of News & Views articles. In this new type of
article - called News & Views Forum - two separate opinions about a
paper are given, with the aim of offering diversity of views on
selected high-impact research.

The latest News & Views Forum relates to a study reporting direct
reprogramming of pancreatic α cells to β cells. Kenneth Zaret writes
about the science behind this process, whereas Morris White discusses
what the findings mean for the treatment of diabetes.

Access the News & Views Forum article in this week's Nature.

http://links.ealert.nature.com/ctt?kn=89&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0
=====================================================================

----------------------
EDITORIALS
----------------------
Nuclear ambition p1103
The US weapons labs need to develop a twenty-first-century vision of
deterrence -- one that does not include making new bombs.
doi:10.1038/4641103a
http://links.ealert.nature.com/ctt?kn=96&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

The weight of evidence pp1103-1104
Better chemical-control legislation is a good start, but scientific
reform should parallel legal reform.
doi:10.1038/4641103b
http://links.ealert.nature.com/ctt?kn=94&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

Time for libel-law reform p1104
Simon Singh's recent libel result is a victory for science, but the
real fight lies ahead.
doi:10.1038/4641104a
http://links.ealert.nature.com/ctt?kn=85&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

----------------------
RESEARCH HIGHLIGHTS
----------------------
Planetary science: Moon grab p1106
doi:10.1038/4641106a
http://links.ealert.nature.com/ctt?kn=60&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

Neuroscience: Relief from pain p1106
doi:10.1038/4641106b
http://links.ealert.nature.com/ctt?kn=65&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

Biomaterials: Electronics on the brain p1106
doi:10.1038/4641106c
http://links.ealert.nature.com/ctt?kn=72&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

Cultural evolution: High fidelity p1106
doi:10.1038/4641106d
http://links.ealert.nature.com/ctt?kn=77&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

Cell biology: Toxin tackle p1106
doi:10.1038/4641106e
http://links.ealert.nature.com/ctt?kn=123&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

Chemistry: Plumbing carbon rings pp1106-1107
doi:10.1038/4641106f
http://links.ealert.nature.com/ctt?kn=108&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

Cancer biology: Cells combat chemo p1107
doi:10.1038/4641107a
http://links.ealert.nature.com/ctt?kn=102&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

Neuroscience: Sharpening social skills p1107
doi:10.1038/4641107b
http://links.ealert.nature.com/ctt?kn=120&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

Climate change: Fewer, taller, fiercer p1107
doi:10.1038/4641107c
http://links.ealert.nature.com/ctt?kn=114&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

Immunology: Inflammatory good guys p1107
doi:10.1038/4641107d
http://links.ealert.nature.com/ctt?kn=43&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

----------------------
JOURNAL CLUB
----------------------
Journal club p1107
Kevin Mitchell
doi:10.1038/4641107e
http://links.ealert.nature.com/ctt?kn=40&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

----------------------
NEWS
----------------------
News briefing: 22 April 2010 pp1108-1109
The week in science
doi:10.1038/4641108a
http://links.ealert.nature.com/ctt?kn=222&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

A shot in the arm for cancer vaccines? pp1110-1111
Researchers anxiously await a decision by US regulators on a
controversial cancer therapy.
Heidi Ledford
doi:10.1038/4641110a
http://links.ealert.nature.com/ctt?kn=242&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

No gain from brain training p1111
Computerized mental workouts don't boost mental skills, study claims.
Alla Katsnelson
doi:10.1038/4641111a
http://links.ealert.nature.com/ctt?kn=240&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

Portrait of a year-old pandemic pp1112-1113
'Swine flu' isn't over yet, but it already holds lessons for the
future.
Declan Butler
doi:10.1038/4641112a
http://links.ealert.nature.com/ctt?kn=238&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

Undersea project delivers data flood p1115
Sea-floor observatory in the Pacific Ocean to provide terabytes of
data.
Nicola Jones
doi:10.1038/4641115a
http://links.ealert.nature.com/ctt?kn=236&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

Crucial data on REACH not disclosed pp1116-1117
Disagreement flares up over the number of animals required to
implement Europe's chemical-safety law.
Natasha Gilbert
doi:10.1038/4641116a
http://links.ealert.nature.com/ctt?kn=269&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

----------------------
NEWS FEATURES
----------------------
Environmental science: New life for the Dead Sea? pp1118-1120
A conduit from the Red Sea could restore the disappearing Dead Sea
and slake the region's thirst. But such a massive engineering project
could have untold effects, reports Josie Glausiusz.
Josie Glausiusz
doi:10.1038/4641118a
http://links.ealert.nature.com/ctt?kn=266&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

Toxicology: The big test for bisphenol A pp1122-1124
After years of wrangling over the chemical's toxicity, researchers
are charting a new way forwards. Brendan Borrell investigates how the
debate has reshaped environmental-health studies.
Brendan Borrell
doi:10.1038/4641122a
http://links.ealert.nature.com/ctt?kn=264&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

----------------------
CORRESPONDENCE
----------------------
Climate policy: role of scientists in public advocacy p1125
Stephen H. Schneider
doi:10.1038/4641125a
http://links.ealert.nature.com/ctt?kn=36&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

Climate policy: dissent over moral as well as factual issues p1125
Gregor Betz
doi:10.1038/4641125b
http://links.ealert.nature.com/ctt?kn=38&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

What users really want to know from university ratings p1125
Jimmy J. Zhuang, Annie X. Wang and Joyce Y. Zhang
doi:10.1038/4641125c
http://links.ealert.nature.com/ctt?kn=32&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

African students value the results of studying in China p1125
Kenneth King
doi:10.1038/4641125d
http://links.ealert.nature.com/ctt?kn=34&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

Actions speak louder than words to prevent language extinctions p1125
Yoshina Gautam and Aashish Jha
doi:10.1038/4641125e
http://links.ealert.nature.com/ctt?kn=51&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

----------------------
OPINION
----------------------
Copenhagen Accord pledges are paltry pp1126-1128
Current national emissions targets can't limit global warming to 2
[deg]C, calculate Joeri Rogelj, Malte Meinshausen and colleagues --
they might even lock the world into exceeding 3 [deg]C warming.
Joeri Rogelj et al.
doi:10.1038/4641126a
http://links.ealert.nature.com/ctt?kn=49&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

----------------------
BOOKS AND ARTS
----------------------
Building life from the bottom up pp1129-1130
Engineering biological systems and organisms is a costly team effort
and may be incompatible with an open-source regulatory environment,
finds Michael A. Goldman.
Michael A. Goldman reviews Biology is Technology: The Promise, Peril,
and New Business of Engineering Life by Robert H. Carlson
doi:10.1038/4641129a
http://links.ealert.nature.com/ctt?kn=47&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

Why twins age differently pp1130-1131
Michael Sargent reviews Epigenetics of Aging by Trygve O. Tollefsbol
doi:10.1038/4641130a
http://links.ealert.nature.com/ctt?kn=45&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

Where the wilderness line blurs p1131
Emma Marris reviews Living Through the End of Nature: The Future of
American Environmentalism by Paul Wapner
doi:10.1038/4641131a
http://links.ealert.nature.com/ctt?kn=44&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

----------------------
NEWS AND VIEWS
----------------------
Diabetes forum: Extreme makeover of pancreatic [alpha]-cells
pp1132-1133
Most insulin-secreting pancreatic [beta]-cells are irreplaceably lost
in type 1 diabetes. In a mouse model, pancreatic [alpha]-cells seem
to sacrifice their identity to replenish the low stock of [beta]-cells.
Two experts discuss what this means for understanding the basic cell
biology involved and its relevance to treating diabetes.
Kenneth S. Zaret and Morris F. White
doi:10.1038/4641132a
http://links.ealert.nature.com/ctt?kn=89&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

Quantum measurement: A condensate's main squeeze pp1133-1134
Entanglement between particles permits the quantum uncertainty in one
variable to be reduced at the cost of increasing that in another.
Condensates are an ideal system in which this technique can be studied.
Charles A. Sackett
doi:10.1038/4641133a
http://links.ealert.nature.com/ctt?kn=2&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

Neuroscience: Signals far and away pp1134-1136
The neocortex of the mammalian brain mediates functions such as
sensory perception and ultimately consciousness and language. The
spread of local signals across large distances in this brain region
has now been clarified.
Dirk Feldmeyer
doi:10.1038/4641134a
http://links.ealert.nature.com/ctt?kn=7&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

Chemistry: Not just any old anion pp1136-1137
Unlike its neighbours on the right-hand side of the periodic table,
boron barely forms an anion. A new trick has been established that
allows it to do so, enabling a highly unusual complex to be prepared.
Kyoko Nozaki
doi:10.1038/4641136a
http://links.ealert.nature.com/ctt?kn=25&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

Materials science: A cloak of liquidity pp1137-1138
Droplets of a liquid alloy on a silicon surface can rearrange the
surface atoms so that they mimic the short-range ordering of atoms in
the alloy. Remarkably, this effect inhibits freezing of the droplets.
A. Lindsay Greer
doi:10.1038/4641137a
http://links.ealert.nature.com/ctt?kn=19&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

50 & 100 years ago p1138
doi:10.1038/4641138b
http://links.ealert.nature.com/ctt?kn=21&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

Infectious disease: Listeria does it again pp1138-1139
Proteins are synthesized by ribosomes, and then commonly undergo
further modifications. A new example of how these host-cell processes
can e subverted by a pathogenic bacterium has come to light.
Julian I. Rood
doi:10.1038/4641138a
http://links.ealert.nature.com/ctt?kn=272&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

Q&A: Animal behaviour: Magnetic-field perception pp1140-1142
The ability to perceive Earth's magnetic field, which at one time was
dismissed as a physical impossibility, is now known to exist in
diverse animals. The receptors for the magnetic sense remain elusive.
But it seems that at least two underlying mechanisms exist --
sometimes in the same organism.
Kenneth J. Lohmann
doi:10.1038/4641140a
http://links.ealert.nature.com/ctt?kn=279&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

----------------------
ARTICLES
----------------------
Generation of a novel wing colour pattern by the Wingless morphogen
pp1143-1148
Here, the generation and evolution of the complex spotted wing pattern
of Drosophila guttifera are investigated. The findings show that wing
spots are induced by the Wingless morphogen, and that the elaborate
spot pattern evolved from simpler schemes by co-option of Wingless
expression at new sites. This type of process is likely to occur in
other animals, too.
Thomas Werner, Shigeyuki Koshikawa, Thomas M. Williams and
Sean B. Carroll
doi:10.1038/nature08896
Abstract: http://links.ealert.nature.com/ctt?kn=261&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=288&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

Conversion of adult pancreatic [agr]-cells to [bgr]-cells after
extreme [bgr]-cell loss pp1149-1154
In the pancreas, insulin-producing [beta]-cells are long-lived and
generally replicate seldom. They can do so, however, after increased
metabolic demand or after injury. Here, a new transgenic model is
developed in which [beta]-cells are nearly completely ablated in mice.
If given insulin, these mice survive, and grow new [beta]-cells.
Lineage-tracing shows that these new [beta]-cells come from
[alpha]-cells, revealing a previously disregarded degree of pancreatic
cell plasticity.
Fabrizio Thorel et al.
doi:10.1038/nature08894
Abstract: http://links.ealert.nature.com/ctt?kn=276&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=11&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

Lateral competition for cortical space by layer-specific horizontal
circuits pp1155-1160
A common anatomical feature of the sensory cortex in many species is
that neurons with similar features cluster into vertically orientated
domains spanning all layers of the cortex. Moreover, neurons in one
domain modulate neurons in neighbouring domains through horizontal
connections. A combination of techniques has now been used to show
that such horizontal projections suppress layers of cortex devoted
to processing inputs, but facilitate layers devoted to outputs.
Hillel Adesnik and Massimo Scanziani
doi:10.1038/nature08935
Abstract: http://links.ealert.nature.com/ctt?kn=271&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=28&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

----------------------
LETTERS
----------------------
Possible thermochemical disequilibrium in the atmosphere of the
exoplanet GJ 436b pp1161-1164
Here, the atmosphere of the extrasolar planet GJ 436b is studied
during its 'secondary eclipse'. The findings reveal the presence of
some H2O and traces of CO2. The best-fit compositional models contain
a high CO abundance and a substantial methane deficiency relative to
thermochemical equilibrium models for the predicted hydrogen-dominated
atmosphere. Disequilibrium processes such as vertical mixing and
polymerization of methane may be required to explain this small
methane-to-CO ratio.
Kevin B. Stevenson et al.
doi:10.1038/nature09013
Abstract: http://links.ealert.nature.com/ctt?kn=273&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=253&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

Nonlinear atom interferometer surpasses classical precision limit
pp1165-1169
The precision of interferometers -- used in metrology and in the
state-of-the-art time standard -- is generally limited by classical
statistics. Here it is shown that the classical precision limit can
be beaten by using nonlinear atom interferometry with Bose-Einstein
condensates.
C. Gross et al.
doi:10.1038/nature08919
Abstract: http://links.ealert.nature.com/ctt?kn=282&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=5&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

Atom-chip-based generation of entanglement for quantum metrology
pp1170-1173
Atom chips provide a versatile quantum laboratory for experiments
with ultracold atomic gases, but techniques to control atomic
interactions and to generate entanglement have been unavailable so
far. Here, the experimental generation of multi-particle entanglement
on an atom chip is described. The technique is used to produce
spin-squeezed states of a two-component Bose-Einstein condensate,
which should be useful for quantum metrology.
Max F. Riedel et al.
doi:10.1038/nature08988
Abstract: http://links.ealert.nature.com/ctt?kn=284&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=6&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

Substrate-enhanced supercooling in AuSi eutectic droplets
pp1174-1177
Supercooling is a phenomenon by which a liquid remains in its fluid
phase well below its melting point. Supercooling can be inhibited by
the presence of a solid surface, whereby crystalline surfaces cause
adjacent atoms in the liquid to become ordered, inducing crystal
nucleation of the melt. Here it is shown that a particular surface
ordering of gold atoms on top of a silicon substrate can stabilize
the liquid phase of a gold-silicon eutectic droplet, and thus enhance
supercooling.
T. U. Schülli et al.
doi:10.1038/nature08986
Abstract: http://links.ealert.nature.com/ctt?kn=277&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=18&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

Stoichiometric control of organic carbon-nitrate relationships from
soils to the sea pp1178-1181
The accumulation of nitrate in freshwater and coastal marine ecosystems
is one of the consequences of the worldwide production of artificial
fertilizers. Here it is shown that nitrate accumulation in ecosystems
shows consistent and negative nonlinear correlations with organic
carbon availability, along a continuum from soils, through freshwater
systems and coastal margins, to the open ocean. This pattern can be
explained by carbon:nitrate ratios, which influence nitrate
accumulation by regulating microbial processes.
Philip G. Taylor and Alan R. Townsend
doi:10.1038/nature08985
Abstract: http://links.ealert.nature.com/ctt?kn=280&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=216&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

Learning-related fine-scale specificity imaged in motor cortex
circuits of behaving mice pp1182-1186
It is generally accepted that specific neuronal circuits in the
brain's cortex drive behavioural execution, but the relationship
between the performance of a task and the function of a circuit is
unknown. Here, this problem was tackled by using a technique that
allows many neurons within the same circuit to be monitored
simultaneously. The findings indicate that enhanced correlated
activity in specific ensembles of neurons can identify and encode
specific behavioural responses while a task is learned.
Takaki Komiyama et al.
doi:10.1038/nature08897
Abstract: http://links.ealert.nature.com/ctt?kn=289&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=106&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

Genetic analysis of variation in transcription factor binding in
yeast pp1187-1191
Variation in the regulation of gene transcription between individuals
is thought to be a major cause of phenotypic diversity. Here,
individual differences in the binding of transcription-factor
proteins are studied. A well-known transcription factor in the yeast
pheromone pathway is used as an example, and the underlying genetic
loci responsible for variation in its binding are mapped. The study
reveals new insights into the mechanisms of gene regulation, and new
regulators of the yeast pheromone pathway.
Wei Zheng et al.
doi:10.1038/nature08934
Abstract: http://links.ealert.nature.com/ctt?kn=291&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=118&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

Listeria monocytogenes impairs SUMOylation for efficient infection
pp1192-1195
SUMOylation is a post-translational protein modification that affects
many eukaryotic cellular processes. It is shown here that cellular
infection with Listeria monocytogenes induces degradation of one of
the essential SUMOylation enzymes, Ubc9, through a mechanism that
involves a bacterial toxin, listeriolysin O. This effect on
SUMOylation may support efficient infection by Listeria.
David Ribet et al.
doi:10.1038/nature08963
Abstract: http://links.ealert.nature.com/ctt?kn=286&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=281&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

MicroRNA-mediated integration of haemodynamics and Vegf signalling
during angiogenesis pp1196-1200
During embryonic development, blood vessels remodel in response to
blood flow. Here, a genetic pathway is described through which this
mechanosensory stimulus is integrated with early developmental signals
to remodel vessels of the aortic arch in zebrafish. It is found that
the flow-induced transcription factor klf2a is required to induce the
expression of an endothelial-specific microRNA, activating signalling
through the growth factor Vegf.
Stefania Nicoli et al.
doi:10.1038/nature08889
Abstract: http://links.ealert.nature.com/ctt?kn=205&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=59&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

Caspase activation precedes and leads to tangles pp1201-1204
Fibrillar deposits of tau protein (neurofibrillary tangles) are
thought to cause neuronal death in patients with Alzheimer's disease,
and tau-related frontotemporal dementia. Here, however, the opposite
has been found: the activation of executioner caspase enzymes occurs
first, preceding tangle formation by hours to days. Tangle-bearing
neurons seem to be long-lived, indicating that tangles might be 'off
pathway' to acute neuronal death.
Alix de Calignon et al.
doi:10.1038/nature08890
Abstract: http://links.ealert.nature.com/ctt?kn=206&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=67&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

Crystal structure of the FTO protein reveals basis for its substrate
specificity pp1205-1209
The fat mass and obesity-associated (FTO) gene has been associated
with increased body weight. The FTO protein has DNA/RNA demethylase
activity. Here, the crystal structure of human FTO in complex with
the mononucleotide 3-methylthymidine is presented. The structure
provides a basis for understanding the substrate specificity of FTO,
and should serve as a foundation for the design of FTO inhibitors.
Zhifu Han et al.
doi:10.1038/nature08921
Abstract: http://links.ealert.nature.com/ctt?kn=207&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=78&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

Isolation of the elusive supercomplex that drives cyclic electron
flow in photosynthesis pp1210-1213
During photosynthesis, light energy is used by photosystems I and II
to establish electron flow, which ultimately results in the production
of ATP and NADPH. Two modes of electron flow exist, a linear electron
flow and a cyclic electron flow (CEF). The latter pathway generates
more ATP, but its molecular components have been elusive. Here, a
combination of biochemical and spectroscopic techniques has been used
to identify the supercomplex that drives CEF in the green alga
Chlamydomonas reinhardtii.
Masakazu Iwai et al.
doi:10.1038/nature08885
Abstract: http://links.ealert.nature.com/ctt?kn=208&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=164&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

Ku is a 5[prime]-dRP/AP lyase that excises nucleotide damage near
broken ends pp1214-1217
Most agents that generate breaks in DNA leave 'dirty ends' that
cannot be joined immediately; instead, intervening steps are required
to restore the integrity of nucleotides at the break. Here it is
shown that the non-homologous end joining pathway requires a
5[prime]-dRP/AP lyase activity to remove abasic sites at
double-strand breaks. Surprisingly, this activity is catalysed by the
Ku70 protein, which, together with its partner Ku86, had been thought
only to recognize broken DNA ends and to recruit other factors that
process ends.
Steven A. Roberts et al.
doi:10.1038/nature08926
Abstract: http://links.ealert.nature.com/ctt?kn=201&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=168&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

Super-resolution biomolecular crystallography with low-resolution
data pp1218-1222
X-ray crystallography has become the most common way for structural
biologists to obtain the three-dimensional structures of proteins and
protein complexes. However, crystals of large macromolecular complexes
often diffract only weakly (yielding a resolution worse than 4 A), so
new methods that work at such low resolution are needed. Here a new
method is described by which to obtain higher-quality electron
density maps and more accurate molecular models of weakly diffracting
crystals.
Gunnar F. Schroder, Michael Levitt and Axel T. Brunger
doi:10.1038/nature08892
Abstract: http://links.ealert.nature.com/ctt?kn=202&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=194&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

----------------------
TECHNOLOGY FEATURE
----------------------
RNA interference: Homing in on delivery pp1225-1228
The scientific community now seems convinced that small RNAs will
become therapies, if new tools can help these large molecules to make
it safely into cells. Monya Baker reports.
Monya Baker
doi:10.1038/4641225a
http://links.ealert.nature.com/ctt?kn=186&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

RNA interference: From tools to therapies p1225
doi:10.1038/4641225b
http://links.ealert.nature.com/ctt?kn=184&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

RNA interference: MicroRNAs as biomarkers p1227
doi:10.1038/4641227a
http://links.ealert.nature.com/ctt?kn=190&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

RNA interference: Table of suppliers pp1229-1230
doi:10.1038/4641229a
http://links.ealert.nature.com/ctt?kn=188&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

----------------------
NATUREJOBS
----------------------
News
Science outreach scheme ramps up p1233
More than 2,500 US scientists are participating in new initiative.
Karen Kaplan
doi:10.1038/nj7292-1233a
http://links.ealert.nature.com/ctt?kn=128&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

Prospects
The junior senior supervisor p1233
Mentoring students as a young researcher has its own particular
challenges, suggests Fabio Paglieri.
Fabio Paglieri
doi:10.1038/nj7292-1233b
http://links.ealert.nature.com/ctt?kn=132&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

Careers and Recruitment
Making a switch p1234
When inspiration strikes or desperation sets in, a bold few risk
career suicide and move to new fields. Bryn Nelson reports on what
it takes.
Bryn Nelson
doi:10.1038/nj7292-1234a
http://links.ealert.nature.com/ctt?kn=130&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

----------------------
FUTURES
----------------------
Corrective action p1238
Accidents will happen.
John Gilbey
doi:10.1038/4641238a
http://links.ealert.nature.com/ctt?kn=146&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

----------------------
Advance Online Publication
----------------------
20 April 2010
Putting brain training to the test near-final version
Adrian M. Owen et al.
doi:10.1038/nature09042
Abstract: http://links.ealert.nature.com/ctt?kn=203&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0
PDF: http://links.ealert.nature.com/ctt?kn=204&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

21 April 2010
Chemical genetics strategy identifies an HCV NS5A inhibitor with a
potent clinical effect
Min Gao et al.
doi:10.1038/nature08960
Abstract: http://links.ealert.nature.com/ctt?kn=145&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=145&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

Cell signalling by microRNA165/6 directs gene dose-dependent root
cell fate
Annelie Carlsbecker et al.
doi:10.1038/nature08977
Abstract: http://links.ealert.nature.com/ctt?kn=139&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=139&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

Oxidation of methane by a biological dicopper centre
Ramakrishnan Balasubramanian et al.
doi:10.1038/nature08992
Abstract: http://links.ealert.nature.com/ctt?kn=158&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=158&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

An RNA polymerase II- and AGO4-associated protein acts in RNA-directed
DNA methylation
Zhihuan Gao et al.
doi:10.1038/nature09025
Abstract: http://links.ealert.nature.com/ctt?kn=154&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=154&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

18 April 2010
Evolution of self-compatibility in Arabidopsis by a mutation in the
male specificity gene
Takashi Tsuchimatsu et al.
doi:10.1038/nature08927
Abstract: http://links.ealert.nature.com/ctt?kn=151&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=151&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

The scaffold protein Ste5 directly controls a switch-like mating
decision in yeast
Mohan K. Malleshaiah, Vahid Shahrezaei, Peter S. Swain
and Stephen W. Michnick
doi:10.1038/nature08946
Abstract: http://links.ealert.nature.com/ctt?kn=246&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=246&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

X-ray crystal structure of the light-independent protochlorophyllide
reductase
Norifumi Muraki et al.
doi:10.1038/nature08950
Abstract: http://links.ealert.nature.com/ctt?kn=252&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=252&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

Native GABAB receptors are heteromultimers with a family of auxiliary
subunits
Jochen Schwenk et al.
doi:10.1038/nature08964
Abstract: http://links.ealert.nature.com/ctt?kn=258&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=258&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

=========================== ADVERTISEMENT ===========================
Now on clinpharmpod: Nutraceuticals
http://links.ealert.nature.com/ctt?kn=263&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

Join us on clinpharmpod as we discuss topics related to the dietary
supplement field. This podcast addresses the role clinical
pharmacology plays in advancing the safety and efficacy of dietary
supplements and the FDA's experience in the first year after
implementation of the Dietary Supplement of Nonprescription Drug
Consumer Protection Act.

Clinpharmpod: Download and discover online at
http://links.ealert.nature.com/ctt?kn=263&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0
=====================================================================

You have been sent this Table of Contents Alert because you have opted in to
receive it. You can change or discontinue your e-mail alerts at any time,
by modifying your preferences on your nature.com account at:
http://links.ealert.nature.com/ctt?kn=41&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0
(You will need to log in to be recognised as a nature.com registrant).

For further technical assistance, please contact our registration department:
registration@nature.com

For print subscription enquiries, please contact our subscription department:
subscriptions@nature.com

For other enquiries, please contact our customer feedback department:
feedback@nature.com

Nature Publishing Group | 75 Varick Street, 9th Floor | New York |
NY 10013-1917 | USA

Nature Publishing Group's worldwide offices:
London - Paris - Munich - New Delhi - Tokyo - Melbourne -
San Diego - San Francisco - Washington - New York - Boston

=====================================================================

Cord Blood America Interview Explains Diversified Revenues

2010-04-21T05:30:00.000-07:00

Release #:812-77574-em-434148:

Cord Blood America Interview Explains Diversified Revenues

Cord Blood America's CEO Matthew Schissler, in Analyst Interview, Discusses Significantly Increasing Revenues

LAS VEGAS, April 21 /PRNewswire-FirstCall/ -- Cord Blood America, Inc. (OTC Bulletin Board: CBAI), the umbilical cord blood stem cell preservation company (http://www.cordblood-america.com ), is focused on bringing the life saving potential of stem cells, a biological insurance policy, to families nationwide and internationally. Its CEO and co-founder, Matthew Schissler, in an interview with analyst Francis Gaskins, said a focus this year is top-line revenue growth.

The announcement that the Cord Blood America is seeking to purchase controlling interest in a major, profitable South American stem cell company could increase revenue by $1.0 to $1.5 million in the next 12 month time period.
The purchase of a stem cell company in Germany, previously announced, could add up to $1 million in revenues also in the next 12 months.
The agreement to collect placentas for a world renowned tissue bank, announced this week, could add up to one million dollars in revenues annually and significantly diversifies the Company's revenue stream.
Cord Blood America recently visited China where its new facility, in partnership with a Chinese pharmaceutical company, will have storage facilities ten times the size of Cord Blood America's new Las Vegas laboratory, which is believed to be the largest of its kind in the U.S. Operations are scheduled to begin in 2011.

The entire interview is available at http://gaskinsco.com/cbai-4-20-10.mp3

About Cord Blood America

Cord Blood America (OTC Bulletin Board: CBAI) is the parent company of CorCell, which facilitates umbilical cord blood stem cell preservation for expectant parents and their children. Its mission is to be the most respected stem cell preservation company in the industry. Collected through a safe and non-invasive process, cord blood stem cells offer a powerful and potentially life-saving resource for treating a growing number of ailments, including cancer, leukemia, blood, and immune disorders. To find out more about Cord Blood America, Inc. (OTC Bulletin Board: CBAI), visit our website at www.corcell.com. For investor information, visit www.cordblood-america.com.

CONTACT:
Paul Knopick
E & E Communications
949/707-5365
pknopick@eandecommunications.com

SOURCE Cord Blood America, Inc.

My EANDE

More Information

Nature Immunology Contents: May 2010 Volume 11 pp 357 - 454

2010-04-21T02:41:00.000-07:00

NATURE IMMUNOLOGY

May 2010 Volume 11 Number 5, pp 357 - 454

Visit Nature Immunology online to browse the journal.

Now available at http://links.ealert.nature.com/ctt?kn=108&m=34805966&r=MTc2NTA4MDAwNgS2&b=2&j=NzIzNzExMTMS1&mt=1&rt=0

Please note that you need to be a subscriber to enjoy full text
access to Nature Immunology online. To purchase a subscription,
please visit:
http://links.ealert.nature.com/ctt?kn=27&m=34805966&r=MTc2NTA4MDAwNgS2&b=2&j=NzIzNzExMTMS1&mt=1&rt=0

Alternatively, to recommend a subscription to your library,
please visit
http://links.ealert.nature.com/ctt?kn=136&m=34805966&r=MTc2NTA4MDAwNgS2&b=2&j=NzIzNzExMTMS1&mt=1&rt=0

=========================== ADVERTISEMENT ===========================

Smaller 25-µg and 25-test size reagents now available.
More color. More choice. More sizes. That's what you can expect from
our ever-expanding portfolio of high quality flow cytometry products.
With the new smaller size reagents, you can more affordably design and
optimize multicolor panels, conduct new experiments, and further your
discovery. Now you really can do more with... less. Welcome to a more
colorful world.(sm)

http://links.ealert.nature.com/ctt?kn=115&m=34805966&r=MTc2NTA4MDAwNgS2&b=2&j=NzIzNzExMTMS1&mt=1&rt=0

=====================================================================

=========================== ADVERTISEMENT ===========================

Buy 4, Get 1 Offer on RayBio Antibody Arrays and ELISA Kits. Detect 200
cytokines quantitatively, measure relative expression of 507 cytokines in a
single sample, or choose from over 500 ELISA kits. Come see us at AAI 2010, Booth 307.

http://links.ealert.nature.com/ctt?kn=66&m=34805966&r=MTc2NTA4MDAwNgS2&b=2&j=NzIzNzExMTMS1&mt=1&rt=0
http://links.ealert.nature.com/ctt?kn=106&m=34805966&r=MTc2NTA4MDAwNgS2&b=2&j=NzIzNzExMTMS1&mt=1&rt=0
http://links.ealert.nature.com/ctt?kn=129&m=34805966&r=MTc2NTA4MDAwNgS2&b=2&j=NzIzNzExMTMS1&mt=1&rt=0
http://links.ealert.nature.com/ctt?kn=61&m=34805966&r=MTc2NTA4MDAwNgS2&b=2&j=NzIzNzExMTMS1&mt=1&rt=0

=====================================================================

=========================== ADVERTISEMENT ===========================

Nature Communications - Now Live!

Nature Communications is a new online-only, multidisciplinary journal
with open access options. Dedicated to publishing high quality primary
research in all areas of the biological, physical and chemical sciences,
articles represent important advances of significance to specialists
within each field.

To celebrate the launch, ALL articles are available to access FREE* at
http://links.ealert.nature.com/ctt?kn=31&m=34805966&r=MTc2NTA4MDAwNgS2&b=2&j=NzIzNzExMTMS1&mt=1&rt=0

*Free access to subscribed-access manuscripts is available until
September 30th, 2010.

=====================================================================

=========================== ADVERTISEMENT ===========================

Nature Network
Personalized. Productive. Collaborative.

Nature Network has re-launched with improved features including a new
workbench. Your workbench can be tailored to your specific needs and
includes a growing library of scientific applications such as Nature
Open Search, Nature Video, MyExperiment Workflow and Novoseek literature
search, as well as tools to help you stay connected to other networks
such as Facebook and Twitter.

Visit http://links.ealert.nature.com/ctt?kn=70&m=34805966&r=MTc2NTA4MDAwNgS2&b=2&j=NzIzNzExMTMS1&mt=1&rt=0 and start customizing your
scientific experience!

=====================================================================

=========================== ADVERTISEMENT ===========================

Get Yourself a Better Pipette
Try the new RAININ Pipet-Lite™ for greater comfort and performance.
The Modern Solution to Accurate, Precise and Tireless Pipetting
Find out more http://links.ealert.nature.com/ctt?kn=21&m=34805966&r=MTc2NTA4MDAwNgS2&b=2&j=NzIzNzExMTMS1&mt=1&rt=0
Great value introductory offers available for a limited time at
http://links.ealert.nature.com/ctt?kn=19&m=34805966&r=MTc2NTA4MDAwNgS2&b=2&j=NzIzNzExMTMS1&mt=1&rt=0

=====================================================================

----------------------
EDITORIAL
----------------------
Of faith and reason p357
doi:10.1038/ni0510-357
The openly religious stance of the NIH director could have
undesirable effects on science education in the United States.
http://links.ealert.nature.com/ctt?kn=24&m=34805966&r=MTc2NTA4MDAwNgS2&b=2&j=NzIzNzExMTMS1&mt=1&rt=0

----------------------
MEETING REPORT
----------------------
The 2010 Midwinter Conference of Immunologists at Asilomar
pp359 - 361
Stephen P Schoenberger, Hilde Cheroutre, Christel Uittenbogaart
and Ann Marshak-Rothstein
doi:10.1038/ni0510-359
A diverse group of immunologists gathered recently at Asilomar,
California, to discuss advances in the theory and practice of
their field. The pristine setting and informal atmosphere have
always made this a unique and memorable conference.
http://links.ealert.nature.com/ctt?kn=13&m=34805966&r=MTc2NTA4MDAwNgS2&b=2&j=NzIzNzExMTMS1&mt=1&rt=0

----------------------
NEWS AND VIEWS
----------------------
HIV-1 and pattern-recognition receptors: a marriage of convenience
pp363 - 365
Michel J Tremblay
doi:10.1038/ni0510-363
Dendritic cells can internalize and degrade invading pathogens in
phagosomes, yet some HIV-1 particles can evade this degradation
process and productively infect dendritic cells. New data show
that HIV-1 replication is triggered by signal-transduction events
through Toll-like receptor 8 and DC-SIGN.
http://links.ealert.nature.com/ctt?kn=14&m=34805966&r=MTc2NTA4MDAwNgS2&b=2&j=NzIzNzExMTMS1&mt=1&rt=0

Unfolding new roles for XBP1 in immunity pp365 - 367
Alex Engel and Gregory M Barton
doi:10.1038/ni0510-365
A critical aspect of innate immune function is the coordinated
regulation of inflammatory gene expression. Now an unexpected
discovery shows that certain signaling components of the unfolded
protein response are required for optimal gene induction by Toll-like
receptors.
http://links.ealert.nature.com/ctt?kn=15&m=34805966&r=MTc2NTA4MDAwNgS2&b=2&j=NzIzNzExMTMS1&mt=1&rt=0

AIMing 2 defend against intracellular pathogens pp367 - 369
Arthur M Krieg
doi:10.1038/ni0510-367
Intracellular pathogens face a diverse array of innate immune
receptors. New data show that a single receptor, AIM2, functions
to detect bacterial or viral DNA in the cytosol, inducing a
protective inflammasome response.
http://links.ealert.nature.com/ctt?kn=16&m=34805966&r=MTc2NTA4MDAwNgS2&b=2&j=NzIzNzExMTMS1&mt=1&rt=0

Another zinc finger in the pie of CD4-CD8 lineage choice
pp370 - 371
Kensuke Takada and Yousuke Takahama
doi:10.1038/ni0510-370
The 'choice' between the CD4+CD8- and CD4-CD8+ T cell lineage
involves genomic specification via a set of transcription factors.
A new study shows that the zinc-finger protein MAZR is another
member of this transcription factor network.
http://links.ealert.nature.com/ctt?kn=1&m=34805966&r=MTc2NTA4MDAwNgS2&b=2&j=NzIzNzExMTMS1&mt=1&rt=0

----------------------
RESEARCH HIGHLIGHTS
----------------------
Research Highlights p372
doi:10.1038/ni0510-372
http://links.ealert.nature.com/ctt?kn=3&m=34805966&r=MTc2NTA4MDAwNgS2&b=2&j=NzIzNzExMTMS1&mt=1&rt=0

----------------------
REVIEW
----------------------
The role of pattern-recognition receptors in innate immunity: update
on Toll-like receptors pp373 - 384
Taro Kawai and Shizuo Akira
doi:10.1038/ni.1863
Abstract: http://links.ealert.nature.com/ctt?kn=2&m=34805966&r=MTc2NTA4MDAwNgS2&b=2&j=NzIzNzExMTMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=5&m=34805966&r=MTc2NTA4MDAwNgS2&b=2&j=NzIzNzExMTMS1&mt=1&rt=0

----------------------
ARTICLES
----------------------
The AIM2 inflammasome is critical for innate immunity to Francisella
tularensis pp385 - 393
Teresa Fernandes-Alnemri et al.
doi:10.1038/ni.1859
The AIM2 inflammasome induces maturation of the proinflammatory
cytokines IL-1beta and IL-18. Using AIM2-deficient mice, Fitzgerald
and colleagues and Alnemri and colleagues show that the AIM2
inflammasome is essential for host defense against cytosolic
bacteria and DNA viruses.
Abstract: http://links.ealert.nature.com/ctt?kn=4&m=34805966&r=MTc2NTA4MDAwNgS2&b=2&j=NzIzNzExMTMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=7&m=34805966&r=MTc2NTA4MDAwNgS2&b=2&j=NzIzNzExMTMS1&mt=1&rt=0

The AIM2 inflammasome is essential for host defense against cytosolic
bacteria and DNA viruses pp395 - 402
Vijay A K Rathinam et al.
doi:10.1038/ni.1864
The AIM2 inflammasome induces maturation of the proinflammatory
cytokines IL-1beta and IL-18. Using AIM2-deficient mice, Fitzgerald
and colleagues and Alnemri and colleagues show that the AIM2
inflammasome is essential for host defense against cytosolic bacteria
and DNA viruses.
Abstract: http://links.ealert.nature.com/ctt?kn=6&m=34805966&r=MTc2NTA4MDAwNgS2&b=2&j=NzIzNzExMTMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=133&m=34805966&r=MTc2NTA4MDAwNgS2&b=2&j=NzIzNzExMTMS1&mt=1&rt=0

Influenza virus activates inflammasomes via its intracellular M2 ion
channel pp404 - 410
Takeshi Ichinohe, Iris K Pang and Akiko Iwasaki
doi:10.1038/ni.1861
The mechanism by which influenza virus activates the NLRP3
inflammasome is unknown. Iwasaki and colleagues show that the
influenza virus M2 protein, a proton-selective ion channel,
stimulates the NLRP3 inflammasome pathway.
Abstract: http://links.ealert.nature.com/ctt?kn=132&m=34805966&r=MTc2NTA4MDAwNgS2&b=2&j=NzIzNzExMTMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=131&m=34805966&r=MTc2NTA4MDAwNgS2&b=2&j=NzIzNzExMTMS1&mt=1&rt=0

TLR activation of the transcription factor XBP1 regulates innate
immune responses in macrophages pp411 - 418
Fabio Martinon, Xi Chen, Ann-Hwee Lee and Laurie H Glimcher
doi:10.1038/ni.1857
The transcription factor XBP1 is activated after endoplasmic
reticulum stress. Glimcher and colleagues show that XBP1 can
also be activated by TLR2 and TLR4 signaling pathways, in which
it sustains proinflammatory cytokine production.
Abstract: http://links.ealert.nature.com/ctt?kn=127&m=34805966&r=MTc2NTA4MDAwNgS2&b=2&j=NzIzNzExMTMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=128&m=34805966&r=MTc2NTA4MDAwNgS2&b=2&j=NzIzNzExMTMS1&mt=1&rt=0

HIV-1 exploits innate signaling by TLR8 and DC-SIGN for productive
infection of dendritic cells pp419 - 426
Sonja I Gringhuis et al.
doi:10.1038/ni.1858
HIV-1 replication requires proviral production of full-length
transcripts. Geijtenbeek and colleagues show that early
Tat-independent HIV-1 replication coopts innate receptor
signaling by DC-SIGN and TLR8 to promote RNA polymerase II
elongation complexes at long terminal repeats.
Abstract: http://links.ealert.nature.com/ctt?kn=124&m=34805966&r=MTc2NTA4MDAwNgS2&b=2&j=NzIzNzExMTMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=126&m=34805966&r=MTc2NTA4MDAwNgS2&b=2&j=NzIzNzExMTMS1&mt=1&rt=0

Capture of influenza by medullary dendritic cells via SIGN-R1 is
essential for humoral immunity in draining lymph nodes pp427 - 434
Santiago F Gonzalez et al.
doi:10.1038/ni.1856
Vaccines elicit neutralizing antibodies to protect organisms against
viral infection. Carroll and colleagues show that medullary lymph
node dendritic cells capture influenza virus via SIGN-R1 and are
necessary for humoral antiviral immunity.
Abstract: http://links.ealert.nature.com/ctt?kn=121&m=34805966&r=MTc2NTA4MDAwNgS2&b=2&j=NzIzNzExMTMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=122&m=34805966&r=MTc2NTA4MDAwNgS2&b=2&j=NzIzNzExMTMS1&mt=1&rt=0

The transcription factor c-Myb primes CD4+CD8+ immature thymocytes
for selection into the iNKT lineage pp435 - 441
Taishan Hu et al.
doi:10.1038/ni.1865
How double-positive thymocytes enter the invariant natural killer T
cell lineage is still unclear. Alberola-Ila and co-workers show that
c-Myb has a central role in this process.
Abstract: http://links.ealert.nature.com/ctt?kn=119&m=34805966&r=MTc2NTA4MDAwNgS2&b=2&j=NzIzNzExMTMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=120&m=34805966&r=MTc2NTA4MDAwNgS2&b=2&j=NzIzNzExMTMS1&mt=1&rt=0

The zinc-finger protein MAZR is part of the transcription factor
network that controls the CD4 versus CD8 lineage fate of
double-positive thymocytes pp442 - 448
Shinya Sakaguchi et al.
doi:10.1038/ni.1860
MAZR is an important negative regulator of CD8 expression. Ellmeier
and colleagues now demonstrate that MAZR directly regulates the
transcription factor Th-POK locus and is therefore involved in CD4
and CD8 cell-fate 'decisions'.
Abstract: http://links.ealert.nature.com/ctt?kn=112&m=34805966&r=MTc2NTA4MDAwNgS2&b=2&j=NzIzNzExMTMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=111&m=34805966&r=MTc2NTA4MDAwNgS2&b=2&j=NzIzNzExMTMS1&mt=1&rt=0

Production of an antigenic peptide by insulin-degrading enzyme
pp449 - 454
Nicolas Parmentier et al.
doi:10.1038/ni.1862
Most antigenic peptides presented by MHC class I are produced by the
proteasome. Van den Eynde and co-workers show that a MAGE-A3-derived
peptide is produced directly by the cytosolic metallopeptidase IDE.
Abstract: http://links.ealert.nature.com/ctt?kn=107&m=34805966&r=MTc2NTA4MDAwNgS2&b=2&j=NzIzNzExMTMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=109&m=34805966&r=MTc2NTA4MDAwNgS2&b=2&j=NzIzNzExMTMS1&mt=1&rt=0

=========================== ADVERTISEMENT ===========================

Announcing Nature Middle East the much awaited portal from
NaturePublishing Group.

Log in for your regular dose of Middle East science, from research
success stories and latest news to information on jobs and events,
in-depth features and commentaries.

Access some hand-picked premium content from various Nature Publishing
Group journals and interact with other readers in the recommended papers
section and the 'House of Wisdom' blog.

http://links.ealert.nature.com/ctt?kn=114&m=34805966&r=MTc2NTA4MDAwNgS2&b=2&j=NzIzNzExMTMS1&mt=1&rt=0

Keep up to date with the latest research coming out of the Arab world
by signing up to Nature Middle East table of contents e-alerts!
Go to http://links.ealert.nature.com/ctt?kn=116&m=34805966&r=MTc2NTA4MDAwNgS2&b=2&j=NzIzNzExMTMS1&mt=1&rt=0 to sign up today.

=====================================================================

You have been sent this Table of Contents Alert because you have
opted in to receive it. You can change or discontinue your e-mail
alerts at any time, by modifying your preferences on your nature.com
account at:
http://links.ealert.nature.com/ctt?kn=100&m=34805966&r=MTc2NTA4MDAwNgS2&b=2&j=NzIzNzExMTMS1&mt=1&rt=0
(You will need to log in to be recognised as a nature.com registrant).

For further technical assistance, please contact our registration
department:
registration@nature.com

For print subscription enquiries, please contact our subscription
department:
subscriptions@nature.com

For other enquiries, please contact our customer feedback department:
feedback@nature.com

Nature Publishing Group | 75 Varick Street, 9th Floor | New York |
NY 10013-1917 | USA

Nature Publishing Group's worldwide offices:
London - Paris - Munich - New Delhi - Tokyo - Melbourne -
San Diego - San Francisco - Washington - New York - Boston

=====================================================================

Cord Blood America Again Diversifies Revenue Stream

2010-04-20T10:35:00.000-07:00

Release #:812-77533-em-434148:

Cord Blood America Again Diversifies Revenue Stream

Cord Blood America to Provide Placentas for Transplantation

LAS VEGAS, April 20 /PRNewswire-FirstCall/ -- Cord Blood America, Inc. (OTC Bulletin Board: CBAI), the umbilical cord blood stem cell preservation company (http://www.cordblood-america.com ) focused on bringing the life saving potential of stem cells, a biological insurance policy, to families nationwide and internationally, announced today that it has signed a Definitive Supplier Agreement with a well-respected, accredited, tissue bank providing placenta collection services for therapeutic transplantation, and Cord Blood America is already filling orders.

The placenta (sometimes called afterbirth) connects the developing fetus to the uterine wall and supplies the fetus with oxygen and food. It is normally discarded at birth. Recent research has shown that there are significant numbers of stem cells in the placenta and they can be safely extracted for transplantation.

These stem cells are currently used to cure chronic blood-related disorders such as sickle cell disease, thalassemia and leukemia, and research is ongoing on utilizing stem cells in treatments of a number of chronic medical conditions including diabetes, heart disease and stroke.

"CBAI has committed to diversify our revenue streams. This contract drives revenues to CBAI for supplying a different source of stem cells. It's the dawn of a new and exciting era for CBAI," said Matthew Schissler, Cord Blood America co-founder and CEO. Terms of the agreement were not disclosed. "Because of the sensitive nature of the project, and intellectual property rights involved, we can only provide a limited amount of detail. However, we wanted to let our shareholders know a different revenue stream has been consummated, one in which we have extreme enthusiasm."

About Cord Blood America

CONTACT:
Paul Knopick
E & E Communications
949/707-5365
pknopick@eandecommunications.com

SOURCE Cord Blood America, Inc.

My EANDE

More Information

Cord Blood America Due Diligence Announcement

2010-04-19T11:16:00.000-07:00

Release #:812-77487-em-434148:

Cord Blood America Due Diligence Announcement

Cord Blood America Signs Letter of Intent to Purchase Controlling Interest in BioCells, Inc., a Major, Profitable South American Company

BioCells, the second largest stem cell storage company in Argentina, is profitable, with annual revenues in 2009 of $1.2 million (USD), and 12 locations throughout that country, plus recent expansion into Uruguay and Paraguay. On February 8, 2010, Cord Blood America announced that BioCells finalized an agreement to process and store cord blood specimens with Cord Blood America in Las Vegas.

"The transaction is subject to the normal due diligence process," said Matthew Schissler, Cord Blood America co-founder and CEO. "We believe this potential transaction is an excellent example of how we are building Cord Blood America into the world's premier stem cell storage company. If successful in due diligence, this will give CBAI a majority stake in a proven South American company. Adding our recently announced acquisition in Europe and our Licensing Agreement in China, this step further proves our commitment to our mission, becoming the world's largest stem cell storage company and creating the cellular pharmacy business model which will be in high demand in years to come."

About Cord Blood America

Cord Blood America (OTC Bulletin Board:CBAI.ob - News) is the parent company of CorCell, which facilitates umbilical cord blood stem cell preservation for expectant parents and their children. Its mission is to be the most respected stem cell preservation company in the industry. Collected through a safe and non-invasive process, cord blood stem cells offer a powerful and potentially life-saving resource for treating a growing number of ailments, including cancer, leukemia, blood, and immune disorders. To find out more about Cord Blood America, Inc. (OTC Bulletin Board:CBAI.ob - News), visit our website at http://www.corcell.com/. For investor information, visit http://www.cordblood-america.com/.

CONTACT:
Paul Knopick
E & E Communications
949/707-5365
pknopick@eandecommunications.com

Forward-Looking Statements

Some statements made in this press release are forward-looking statements, which are made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. We use words such as "anticipate,'' "believe,'' "expect,'' "future,'' "intend,'' "plan,'' and similar expressions to identify forward-looking statements. These statements including those related to the growth of the industry, new stem cell treatments, and the Company's performance, are only predictions and are subject to certain risks, uncertainties and assumptions. Additional risks are identified and described in the Company's public filings with the Securities and Exchange Commission. Statements made herein are as of the date of this press release and should not be relied upon as of any subsequent date. The Company's past performance is not necessarily indicative of its future performance. The Company does not undertake, and the Company specifically disclaims any obligation to update any forward-looking statements to reflect occurrences, developments, events, or circumstances after the date of such statement

My EANDE

More Information

Cancer Gene Therapy - Table of Contents alert Volume 17 Issue 5

2010-04-19T05:50:00.001-07:00

CANCER GENE THERAPY

May 2010 Volume 17 Number 5, pp 299 - 374
---------------------------------------------------------------------
Use far less starting material for RNA Labeling while maintaining
the same high sensitivity analysis expected from Agilent gene expression
arrays. Just launched - the new Low Input Quick Amp Labeling Kit,
allowing you to detect both low- and high-expressors, while you
conserve on precious RNA samples. Learn how at
opengenomics.com/low_input_quickamp.

http://links.ealert.nature.com/ctt?kn=73&m=34799261&r=MTc3MTg1MDcyMQS2&b=2&j=NzIyNjkxMjUS1&mt=1&rt=0
---------------------------------------------------------------------
Call for papers - Nature Communications

Nature Communications, an innovative new online science journal,
launching in spring 2010, is now accepting submissions. The journal
will provide a unique forum for the rapid publication of high-quality
Articles, from short communications to longer format research papers,
covering all areas of the physical, chemical and biological sciences.

Submit now at
http://links.ealert.nature.com/ctt?kn=18&m=34799261&r=MTc3MTg1MDcyMQS2&b=2&j=NzIyNjkxMjUS1&mt=1&rt=0

----------------------
ORIGINAL ARTICLES
----------------------
Human neural stem cells transduced with IFN-[beta] and cytosine
deaminase genes intensify bystander effect in experimental glioma
S Ito, A Natsume, S Shimato, M Ohno, T Kato, P Chansakul, T
Wakabayashi and S U Kim
Abstract: http://links.ealert.nature.com/ctt?kn=63&m=34799261&r=MTc3MTg1MDcyMQS2&b=2&j=NzIyNjkxMjUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=61&m=34799261&r=MTc3MTg1MDcyMQS2&b=2&j=NzIyNjkxMjUS1&mt=1&rt=0

CUG2, a novel oncogene confers reoviral replication through Ras and
p38 signaling pathway
E-H Park, E H Park, I-R Cho, R Srisuttee, H-J Min, M-J Oh, Y-J Jeong,
B H Jhun, R N Johnston, S Lee, S S Koh and Y-H Chung
Abstract: http://links.ealert.nature.com/ctt?kn=21&m=34799261&r=MTc3MTg1MDcyMQS2&b=2&j=NzIyNjkxMjUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=26&m=34799261&r=MTc3MTg1MDcyMQS2&b=2&j=NzIyNjkxMjUS1&mt=1&rt=0

Using lentiviral vectors for efficient pancreatic cancer gene therapy
E Ravet, H Lulka, F Gross, L Casteilla, L Buscail and P Cordelier
Abstract: http://links.ealert.nature.com/ctt?kn=28&m=34799261&r=MTc3MTg1MDcyMQS2&b=2&j=NzIyNjkxMjUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=23&m=34799261&r=MTc3MTg1MDcyMQS2&b=2&j=NzIyNjkxMjUS1&mt=1&rt=0

Intratumoral delivery of shRNA targeting cyclin D1 attenuates
pancreatic cancer growth
S J Deharvengt, J R Gunn, S B Pickett and M Korc
Abstract: http://links.ealert.nature.com/ctt?kn=25&m=34799261&r=MTc3MTg1MDcyMQS2&b=2&j=NzIyNjkxMjUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=13&m=34799261&r=MTc3MTg1MDcyMQS2&b=2&j=NzIyNjkxMjUS1&mt=1&rt=0

Tumor-targeted delivery of biologically active TRAIL protein
H-Y Zhang, J-H Man, B Liang, T Zhou, C-H Wang, T Li, H-Y Li, W-H Li,
B-F Jin, P-J Zhang, J Zhao, X Pan, K He, W-L Gong, X-M Zhang and A-L Li
Abstract: http://links.ealert.nature.com/ctt?kn=11&m=34799261&r=MTc3MTg1MDcyMQS2&b=2&j=NzIyNjkxMjUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=10&m=34799261&r=MTc3MTg1MDcyMQS2&b=2&j=NzIyNjkxMjUS1&mt=1&rt=0

Bovine herpesvirus type 1 as a novel oncolytic virus
R Rodrigues, B Cuddington and K Mossman
Abstract: http://links.ealert.nature.com/ctt?kn=9&m=34799261&r=MTc3MTg1MDcyMQS2&b=2&j=NzIyNjkxMjUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=17&m=34799261&r=MTc3MTg1MDcyMQS2&b=2&j=NzIyNjkxMjUS1&mt=1&rt=0

Genetic immunotherapy of lung cancer using conditionally replicating
adenovirus and adenovirus-interferon-[beta]
M-Y Park, D R Kim, H W Jung, H-I Yoon, J H Lee and C-T Lee
Abstract: http://links.ealert.nature.com/ctt?kn=39&m=34799261&r=MTc3MTg1MDcyMQS2&b=2&j=NzIyNjkxMjUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=40&m=34799261&r=MTc3MTg1MDcyMQS2&b=2&j=NzIyNjkxMjUS1&mt=1&rt=0

Down-regulation of HIF-1[alpha] by oncolytic reovirus infection
independently of VHL and p53
I-R Cho, S S Koh, H-J Min, E-H Park, S Ratakorn, B H Jhun, S H Jeong,
Y H Yoo, H D Youn, R N Johnston and Y-H Chung
Abstract: http://links.ealert.nature.com/ctt?kn=41&m=34799261&r=MTc3MTg1MDcyMQS2&b=2&j=NzIyNjkxMjUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=45&m=34799261&r=MTc3MTg1MDcyMQS2&b=2&j=NzIyNjkxMjUS1&mt=1&rt=0

----------------------
LETTER TO THE EDITOR
----------------------
Neuroblastoma-specific expression of potential therapeutics cannot be
achieved using a promoter region of the NCX (TLX2) gene
A Tivnan and R L Stallings
http://links.ealert.nature.com/ctt?kn=46&m=34799261&r=MTc3MTg1MDcyMQS2&b=2&j=NzIyNjkxMjUS1&mt=1&rt=0

---------------------------------------------------------------------
Research Diversity
Limited-time web focus

The Journal of Human Genetics is proud to present Research Diversity -
a limited-time web focus featuring the following topics:

- Susceptibility genes to complex diseases
- Towards personalized medicine
- Ancient DNA and population diversity.

Take advantage of free content through Research Diversity today!
http://links.ealert.nature.com/ctt?kn=33&m=34799261&r=MTc3MTg1MDcyMQS2&b=2&j=NzIyNjkxMjUS1&mt=1&rt=0

=====================================================================

You have been sent this Table of Contents Alert because you have
opted in to receive it.
You can change or discontinue your e-mail alerts at any time, by
modifying your preferences on your nature.com account at:
http://links.ealert.nature.com/ctt?kn=57&m=34799261&r=MTc3MTg1MDcyMQS2&b=2&j=NzIyNjkxMjUS1&mt=1&rt=0
(You will need to log in to be recognised as a nature.com registrant).

For further technical assistance, please contact our registration
department:
registration@nature.com

For print subscription enquiries, please contact our subscription
department:
subscriptions@nature.com

For other enquiries, please contact customer feedback department:
feedback@nature.com

Nature Publishing Group | 75 Varick Street, 9th Floor | New York |
NY 10013-1917 | USA

Nature Publishing Group's worldwide offices:
London - Paris - Munich - New Delhi - Tokyo - Melbourne - San Diego -
San Francisco - Washington - New York - Boston

Macmillan Publishers Limited is a company incorporated in England and
Wales under company number 785998 and whose registered office is
located at Brunel Road, Houndmills, Basingstoke, Hampshire RG21 6XS.

=====================================================================

Order Your New IRCMB Volume Today

2010-04-19T03:59:00.001-07:00

Share this with colleagues in your social network:

Click here to display this email in a browser.

This dynamic collection of series is written and edited by the most prestigious scholars in the field, selected from Elsevier's extensive global research network. Available online via ScienceDirect, or in print, this highly-regarded and heavily-cited collection ranges from classics such as Advances in Cancer Research, Current Topics in Membranes, and International Review of Cell and Molecular Biology, to cutting-edge series like Advances in Genetics, Current Topics in Developmental Biology and Methods in Cell Biology. It's must-have information that researchers like you should not be without!

Elsevier eSeries on ScienceDirect -- The Perfect Complement to Primary Research, from Library to Lab:

Highly cited, highly accessible to all users, all the time
Structured like eJournals, Elsevier eSeries cover the methodology and in-depth perspective you need to build foundation knowledge
Easy to search and browse eBooks and eJournals to find the information you need, when you need it -- and nothing more
Flexibility to find, download, and print without restriction

Interested? Tell your library to subscribe to this series by July 2010 to get 10 years of backfiles FREE!

"Many book series are used like journals; user is only interested in one article/section, so eBook Series are easier to use."
Jan Lewis, Associate Library Director, East Carolina University

RECOMMEND THIS SERIES ON SCIENCEDIRECT TO YOUR LIBRARIAN!

78% of Librarians Surveyed Would Replace
Their Printed Book Series with Online Book Series

International Review of Cell and Molecular Biology, Vol 280

CONTENTS INCLUDE:

Natriuretic Peptides in the Regulation of the
Hypothalamic-Pituitary-Adrenal Axis
Evidence for Multiple Photosystems in Jellyfish
Membrane Trafficking in Protozoa: SNARE Proteins, H+-ATPase, Actin, and Other Key Players in Ciliates
New Insights into the Types and Function of Proteases in Plastids
Impact of ATP-Binding Cassette Transporters on Human Immunodeficiency Virus Therapy
New Insights into the Circadian Clock in Chlamydomonas

Click here for more info

Details about these and other Book and Handbook Series:

Online via ScienceDirect: onlinebooksonsciencedirect.com/series
In Print: elsevierdirect.com/series

JOIN OUR COMMUNITY

Find us on Facebook

Special Offers
The special offers made in this email are intended for our direct customers, and are not applicable to resellers or other third parties. Prices subject to change.

This e-mail has been sent to manojhind2001us1.stemcell@blogger.com from Elsevier Science & Technology Books, Elsevier Inc, 30 Corporate Drive, 4th Floor, Burlington, MA 01803 United States. To ensure delivery to your inbox (not your bulk or junk folders) please add MolecularBiology.books@mail.elsevier-alerts.com to your address book.

Unsubscribe Privacy Policy
© 2010 Elsevier Inc. All rights reserved.

Stem Cells Accepted Articles for April 16th

2010-04-16T07:04:00.001-07:00

>> If you have trouble viewing this e-mail, you can see this message online <<

Published on behalf of

AlphaMed Press

This Publication Alert is being sent to individuals who requested receipt of this information. For additional details, see the bottom of this message.

Stem Cells Express (Accepted Articles)

Embryonic Stem Cells/Induced Pluripotent Stem Cells

A Role For Borg5 During Trophectoderm Differentiation (p N/A)
Queenie P. Vong, Zhonghua Liu, Jae Gyu Yoo, Rong Chen, Wen Xie, Alexei A. Sharov, Chen-ming Fan, Chengyu Liu, Minoru S. H. Ko, Yixian Zheng
Accepted Article Online: Apr 15 2010 2:41PM
DOI: 10.1002/stem.428

Tissue-Specific Stem Cells

Impaired Hippocampal Neurogenesis and Vascular Formation in Ephrin-A5-Deficient Mice (p N/A)
Yoshinobu Hara, Tadashi Nomura, Kaichi Yoshizaki, Jonas Frisén, Noriko Osumi
Accepted Article Online: Apr 15 2010 2:41PM
DOI: 10.1002/stem.427

This message is sent to subscribers and alert registrants for Stem Cells.

To UNSUBSCRIBE from future mailings go to The Stem Cells Express Alert list.

If you have any questions or concerns about this message, please contact lwoo@wiley.com.
Do not reply directly to this message.

Wiley InterScience is a division of:
John Wiley & Sons, Inc. | 111 River Street | Hoboken, NJ 07030
Phone: 800-225-5945 | Fax: 800-605-2665 | www.wiley.com

>> If you have trouble viewing this e-mail, you can see this message online <<

Nature Reviews Microbiology contents May 2010 Volume 8 Number 5 pp 309-382

2010-04-16T04:48:00.001-07:00

NATURE REVIEWS MICROBIOLOGY

May 2010 Volume 8 Number 5

Visit Nature Reviews Microbiology online to browse the journal.

Now available at http://links.ealert.nature.com/ctt?kn=15&m=34790741&r=MTc2NzM1ODUwNgS2&b=2&j=NzIxMzI3MTUS1&mt=1&rt=0

Please note that you need to be a subscriber to enjoy full text access
to Nature Reviews Microbiology online. To purchase a subscription,
please visit: http://links.ealert.nature.com/ctt?kn=87&m=34790741&r=MTc2NzM1ODUwNgS2&b=2&j=NzIxMzI3MTUS1&mt=1&rt=0

Alternatively, to recommend a subscription to your library, please visit
http://links.ealert.nature.com/ctt?kn=24&m=34790741&r=MTc2NzM1ODUwNgS2&b=2&j=NzIxMzI3MTUS1&mt=1&rt=0

*********************************************************************
Nature Reviews Microbiology Impact Factor: 14.310*
*2008 Journal Citation Report (Thomson Reuters, 2009)
*********************************************************************

=========================== ADVERTISEMENT ===========================

Find over 5,000 vacancies across scientific disciplines as well as the
latest job market news, career advice and more, only at...

naturejobs.com
http://links.ealert.nature.com/ctt?kn=22&m=34790741&r=MTc2NzM1ODUwNgS2&b=2&j=NzIxMzI3MTUS1&mt=1&rt=0

ATTENTION EMPLOYERS! Stay up to date with Naturejobs advertising
deadlines and upcoming features:
http://links.ealert.nature.com/ctt?kn=98&m=34790741&r=MTc2NzM1ODUwNgS2&b=2&j=NzIxMzI3MTUS1&mt=1&rt=0 or
telephone:

US: + 1 800 989 7718
EUR: +44 (0) 20 7843 4961

=========================== ADVERTISEMENT ===========================

Nature Reviews Microbiology
Focus on Antimicrobial Resistance

Resistance to antimicrobials is becoming increasingly common, raising
the concern that bacterial infections that can currently be controlled
could become a major health threat again, as well as undermining
efforts to combat diseases such as malaria.

To highlight the problem of resistance to antimicrobials,
Nature Reviews Microbiology presents a set of specially commissioned
articles that focus on key issues in the field.

Visit http://links.ealert.nature.com/ctt?kn=70&m=34790741&r=MTc2NzM1ODUwNgS2&b=2&j=NzIxMzI3MTUS1&mt=1&rt=0 to access the Focus.

=========================== ADVERTISEMENT ===========================

Nature Communications - Now Live!

Nature Communications is a new online-only, multidisciplinary journal
with open access options. Dedicated to publishing high quality primary
research in all areas of the biological, physical and chemical sciences,
articles represent important advances of significance to specialists
within each field.

To celebrate the launch, ALL articles are available to access FREE* at
http://links.ealert.nature.com/ctt?kn=69&m=34790741&r=MTc2NzM1ODUwNgS2&b=2&j=NzIxMzI3MTUS1&mt=1&rt=0

*Free access to subscribed-access manuscripts is available until
September 30th, 2010.

=====================================================================

In this issue
p309 | doi:10.1038/nrmicro2352
http://links.ealert.nature.com/ctt?kn=31&m=34790741&r=MTc2NzM1ODUwNgS2&b=2&j=NzIxMzI3MTUS1&mt=1&rt=0

Editorial: China: a life sciences giant
p310 | doi:10.1038/nrmicro2364
Life science research in China continues to expand rapidly. Support
from the Chinese government and a thriving research community,
including in the field of microbiology, are making China an increasingly
important contributor to the life sciences.
http://links.ealert.nature.com/ctt?kn=33&m=34790741&r=MTc2NzM1ODUwNgS2&b=2&j=NzIxMzI3MTUS1&mt=1&rt=0

----------------------
RESEARCH HIGHLIGHTS
----------------------
Fungal genetics: Expanding horizons through chromosome exchange
p311 | doi:10.1038/nrmicro2357
The exchange of chromomes between plant-pathogenic fungi can alter
the host range of the pathogens.
http://links.ealert.nature.com/ctt?kn=39&m=34790741&r=MTc2NzM1ODUwNgS2&b=2&j=NzIxMzI3MTUS1&mt=1&rt=0

Bacterial virulence: Modifying virulent behaviour
p312 | doi:10.1038/nrmicro2353
Cj0256-mediated phosphoethanolamine modification of lipo-oligosaccharide
and the flagellar rod protein FlgG couples membrane biogenesis and
motility in Campylobacter jejuni.
http://links.ealert.nature.com/ctt?kn=67&m=34790741&r=MTc2NzM1ODUwNgS2&b=2&j=NzIxMzI3MTUS1&mt=1&rt=0

Techniques and applications: Real-time view of AMP-mediated killing
p312 | doi:10.1038/nrmicro2355
Following the kinetics of antimicrobial peptide (AMP) activity on a
bacterial cell surface using high speed atomic force microscopy.
http://links.ealert.nature.com/ctt?kn=63&m=34790741&r=MTc2NzM1ODUwNgS2&b=2&j=NzIxMzI3MTUS1&mt=1&rt=0

Plant immunity: Helping plants to fight back
p312 | doi:10.1038/nrmicro2358
The expression of heterologous pattern recognition receptors in plants
can confer broad-spectrum antibacterial resistance.
http://links.ealert.nature.com/ctt?kn=6&m=34790741&r=MTc2NzM1ODUwNgS2&b=2&j=NzIxMzI3MTUS1&mt=1&rt=0

IN BRIEF
Fungal physiology | Viral immune evasion | Metagenomics
p313 | doi:10.1038/nrmicro2362
http://links.ealert.nature.com/ctt?kn=65&m=34790741&r=MTc2NzM1ODUwNgS2&b=2&j=NzIxMzI3MTUS1&mt=1&rt=0

HIV: Second hideout for HIV-1
p314 | doi:10.1038/nrmicro2359
Immature multipotent haematopoietic progenitor cells are identified as
another reservoir for latent HIV-1 infection.
http://links.ealert.nature.com/ctt?kn=13&m=34790741&r=MTc2NzM1ODUwNgS2&b=2&j=NzIxMzI3MTUS1&mt=1&rt=0

Bacterial secretion: The two faces of MycP1
p314 | doi:10.1038/nrmicro2360
The subtilin-like serine protease MycP1 has a dual role in ESX1-mediated
secretion.
http://links.ealert.nature.com/ctt?kn=16&m=34790741&r=MTc2NzM1ODUwNgS2&b=2&j=NzIxMzI3MTUS1&mt=1&rt=0

----------------------
NEWS AND ANALYSIS
----------------------
GENOME WATCH
A glut from the gut: metagenomics takes a giant step foward
Alan Walker
p315 | doi:10.1038/nrmicro2363
Interest in the bacteria that inhabit the human gut has increased
greatly in recent years, as technological advancements have allowed
new discoveries. This month's Genome Watch reviews a recent study of
the microorganisms in the human gut that sets a new marker for the
field of metagenomics.
http://links.ealert.nature.com/ctt?kn=21&m=34790741&r=MTc2NzM1ODUwNgS2&b=2&j=NzIxMzI3MTUS1&mt=1&rt=0

DISEASE WATCH
In the News
p316 | doi:10.1038/nrmicro2361
Our monthly round up of infectious diseases news, which this month
includes similarities between Spanish flu and swine flu and decreased
mortality of HIV-infected individuals when prophylactically treated
with co-trimoxazole.
http://links.ealert.nature.com/ctt?kn=20&m=34790741&r=MTc2NzM1ODUwNgS2&b=2&j=NzIxMzI3MTUS1&mt=1&rt=0

----------------------
REVIEWS
----------------------
Bacteriophage resistance mechanisms
Simon J. Labrie, Julie E. Samson and Sylvain Moineau
p317 | doi:10.1038/nrmicro2315
To prevent infection by phages, bacteria have evolved a diverse range
of resistance mechanisms. Moineau and colleagues highlight recent work
to characterize these resistance strategies and discuss how phages have
adapted to overcome many of these mechanisms, triggering an evolutionary
arms race with their hosts.
Abstract: http://links.ealert.nature.com/ctt?kn=76&m=34790741&r=MTc2NzM1ODUwNgS2&b=2&j=NzIxMzI3MTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=75&m=34790741&r=MTc2NzM1ODUwNgS2&b=2&j=NzIxMzI3MTUS1&mt=1&rt=0

Anaplasma phagocytophilum and Ehrlichia chaffeensis: subversive
manipulators of host cells
Yasuko Rikihisa
p328 | doi:10.1038/nrmicro2318
Anaplasma phagocytophilum and Ehrlichia chaffeensis cause the emerging
zoonoses human granulocytic anaplasmosis and human monocytic ehrlichiosis,
respectively, which are among the most prevalent life-threatening
tick-borne zoonoses in the United States. Yasuko Rikihisa reviews
the adaptations of these obligate intracellular bacteria that allow
them to subvert and manipulate host cells.
Abstract: http://links.ealert.nature.com/ctt?kn=74&m=34790741&r=MTc2NzM1ODUwNgS2&b=2&j=NzIxMzI3MTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=78&m=34790741&r=MTc2NzM1ODUwNgS2&b=2&j=NzIxMzI3MTUS1&mt=1&rt=0

Medically important bacterial-fungal interactions
Anton Y. Peleg, Deborah A. Hogan and Eleftherios Mylonakis
p340 | doi:10.1038/nrmicro2313
The human body plays host to interactions between a diverse range of
microorganisms, including bacteria and fungi. In this Review, Mylonakis
and colleagues describe the characteristics of medically important
bacterial-fungal interactions and highlight how imbalances in these
interactions can contribute to human disease.
Abstract: http://links.ealert.nature.com/ctt?kn=79&m=34790741&r=MTc2NzM1ODUwNgS2&b=2&j=NzIxMzI3MTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=80&m=34790741&r=MTc2NzM1ODUwNgS2&b=2&j=NzIxMzI3MTUS1&mt=1&rt=0

A look behind closed doors: interaction of persistent viruses with
dendritic cells
Melanie Lambotin, Sukanya Raghuraman, Francoise Stoll-Keller,
Thomas F. Baumert and Heidi Barth
p350 | doi:10.1038/nrmicro2332
Dendritic cells form an important arm of the innate immune defence and
provide protection against various pathogens. Heidi Barth and colleagues
provide an overview of the interaction of dendritic cells with
hepatitis B virus, hepatitis C virus and HIV.
Abstract: http://links.ealert.nature.com/ctt?kn=82&m=34790741&r=MTc2NzM1ODUwNgS2&b=2&j=NzIxMzI3MTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=83&m=34790741&r=MTc2NzM1ODUwNgS2&b=2&j=NzIxMzI3MTUS1&mt=1&rt=0

The arrival, establishment and spread of exotic diseases: patterns
and predictions
Sarah E. Randolph and David J. Rogers
p361 | doi:10.1038/nrmicro2336
Diseases spread across the world more than ever. Sarah Randolph and
David Rogers use six examples of diseases to explore the factors that
are involved in the spread and establishment of diseases and discuss
how this information can be used to predict where new infections can
take hold and become established.
Abstract: http://links.ealert.nature.com/ctt?kn=84&m=34790741&r=MTc2NzM1ODUwNgS2&b=2&j=NzIxMzI3MTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=85&m=34790741&r=MTc2NzM1ODUwNgS2&b=2&j=NzIxMzI3MTUS1&mt=1&rt=0

----------------------
ANALYSIS
----------------------
Detecting genomic islands using bioinformatics approaches
Morgan G. I. Langille, William W. L. Hsiao and Fiona S. L. Brinkman
p373 | doi:10.1038/nrmicro2350
The identification of genomic islands in bacterial genomes is becoming
increasingly important. In this Analysis article, Fiona Brinkman and
colleagues look at the limitations and benefits of the major computational
methods that are available for genomic island prediction.
Abstract: http://links.ealert.nature.com/ctt?kn=86&m=34790741&r=MTc2NzM1ODUwNgS2&b=2&j=NzIxMzI3MTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=61&m=34790741&r=MTc2NzM1ODUwNgS2&b=2&j=NzIxMzI3MTUS1&mt=1&rt=0

=========================== ADVERTISEMENT ===========================

The Royal Society and Nature present:
Tomorrow's Giants
July 1, 2010 - London, UK

Tomorrow's Giants will bring together scientists and policy makers to
gather scientists' vision of the next 50 years, to address questions such as:
What is required to enable academic achievement of the highest quality?
What will science be like in 10 and in 50 years time? What will be the
main goals and challenges?

Visit http://links.ealert.nature.com/ctt?kn=51&m=34790741&r=MTc2NzM1ODUwNgS2&b=2&j=NzIxMzI3MTUS1&mt=1&rt=0 to apply.

=====================================================================

You have been sent this Table of Contents Alert because you have opted in to
receive it. You can change or discontinue your e-mail alerts at any time,
by modifying your preferences on your nature.com account at:
http://links.ealert.nature.com/ctt?kn=23&m=34790741&r=MTc2NzM1ODUwNgS2&b=2&j=NzIxMzI3MTUS1&mt=1&rt=0
(You will need to log in to be recognised as a nature.com registrant).

For further technical assistance, please contact our registration department:
registration@nature.com

For print subscription enquiries, please contact our subscription department:
subscriptions@nature.com

For other enquiries, please contact our customer feedback department:
feedback@nature.com

Nature Publishing Group | 75 Varick Street, 9th Floor | New York |
NY 10013-1917 | USA

Nature Publishing Group's worldwide offices:
London - Paris - Munich - New Delhi - Tokyo - Melbourne -
San Diego - San Francisco - Washington - New York - Boston

=====================================================================

ScienceDirect Alert: Cell, Vol. 141, Iss. 2, 2010

2010-04-16T04:34:00.001-07:00

New Volume/Issue is now available on ScienceDirect

Cell

Volume 141, Issue 2, Pages 193-370 (16 April 2010)

Leading Edge

In This Issue
Pages 193, 195

Virology Select
Pages 197, 199

Analysis

Video Games and the Second Life of Science Class
Pages 201-203
Amy Maxmen

Commentary

Science in Diplomacy
Pages 204-207
Ahmed H. Zewail

Obituary

Leena Peltonen 1952–2010
Pages 208-209
Michael R. Stratton, Eric Lander

Essay

Genetic Heterogeneity in Human Disease
Pages 210-217
Jon McClellan, Mary-Claire King

Previews

Preventing a Perm with TRPV3
Pages 218-220
Craig Montell

Ubiquitin Gets CARDed
Pages 220-222
Eric J. Bennett, J. Wade Harper

Ricin Toxin Hits a Retrograde Roadblock
Pages 222-224
Matthew N.J. Seaman, Andrew A. Peden

10.

The Hidden Rhythms of the Dividing Cell
Pages 224-226
David O. Morgan

Minireview

11.

How the Sequence of a Gene Can Tune Its Translation
Pages 227-229
Kurt Fredrick, Michael Ibba

Articles

12.

Inhibition of Retrograde Transport Protects Mice from Lethal Ricin Challenge
Pages 231-242
Bahne Stechmann, Siau-Kun Bai, Emilie Gobbo, Roman Lopez, Goulven Merer, Suzy Pinchard, Laetitia Panigai, Danièle Tenza, Graça Raposo, Bruno Beaumelle, Didier Sauvaire, Daniel Gillet, Ludger Johannes, Julien Barbier

Graphical Abstract

► Identification of two toxin inhibitors by cell-based high-throughput screening ► Cells are protected against the plant toxin ricin and bacterial Shiga-like toxins ► Inhibitors selectively block toxin trafficking at endosome-TGN interface ► One compound protects mice from lethal nasal challenge with ricin

13.

53BP1 Inhibits Homologous Recombination in Brca1-Deficient Cells by Blocking Resection of DNA Breaks
Pages 243-254
Samuel F. Bunting, Elsa Callén, Nancy Wong, Hua-Tang Chen, Federica Polato, Amanda Gunn, Anne Bothmer, Niklas Feldhahn, Oscar Fernandez-Capetillo, Liu Cao, Xiaoling Xu, Chu-Xia Deng, Toren Finkel, Michel Nussenzweig, Jeremy M. Stark, André Nussenzweig

Graphical Abstract

► 53BP1 and Brca1 regulate the choice between HR and NHEJ pathways for DNA repair ► 53BP1 deletion promotes HR by increasing ATM-dependent resection of DNA breaks ► 53BP1 mutation protects Brca1-deficient cells from death induced by PARP inhibition ► Lig4 joins unrepaired DNA breaks into radial chromosomes in Brca1 mutant cells

14.

The RAD6 DNA Damage Tolerance Pathway Operates Uncoupled from the Replication Fork and Is Functional Beyond S Phase
Pages 255-267
Georgios I. Karras, Stefan Jentsch

Graphical Abstract

► Error-free and error-prone DNA damage tolerance can function outside S phase ► The RAD6 DNA damage tolerance pathway is independent of the replication fork ► The RAD6 pathway seems to act on single-stranded gaps behind the replication fork

15.

Periodic Cyclin-Cdk Activity Entrains an Autonomous Cdc14 Release Oscillator
Pages 268-279
Ying Lu, Frederick R. Cross

Graphical Abstract

► Constant active mitotic cyclin levels reveal independent Cdc14 release cycles ► Mitotic cyclin levels determine Cdc14 oscillator frequency ► Cyclin-Cdk oscillation might order cell-cycle events through phase-locking

16.

Mitochondrial Fusion Is Required for mtDNA Stability in Skeletal Muscle and Tolerance of mtDNA Mutations
Pages 280-289
Hsiuchen Chen, Marc Vermulst, Yun E. Wang, Anne Chomyn, Tomas A. Prolla, J. Michael McCaffery, David C. Chan

Graphical Abstract

► Mice lacking mitochondrial fusion in skeletal muscle exhibit mitochondrial myopathy ► Fusion is essential for maintenance of mitochondrial DNA (mtDNA) levels ► Loss of mitochondrial fusion results in increased mtDNA mutations ► Fusion protects mitochondrial respiration in cells with high loads of mutated mtDNA

17.

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids
Pages 290-303
Yasemin Sancak, Liron Bar-Peled, Roberto Zoncu, Andrew L. Markhard, Shigeyuki Nada, David M. Sabatini

Graphical Abstract

► Amino acids induce the translocation of mTORC1 to the lysosomal surface ► The lysosomal membrane-associated Ragulator complex interacts with Rag GTPases ► Ragulator is necessary for TORC1 activation by amino acids ► Targeting of mTORC1 to the lysosomal surface eliminates its amino acid sensitivity

18.

LIS1 and NudE Induce a Persistent Dynein Force-Producing State
Pages 304-314
Richard J. McKenney, Michael Vershinin, Ambarish Kunwar, Richard B. Vallee, Steven P. Gross

Graphical Abstract

► NudE recruits LIS1 to dynein to regulate force production ► NudE-LIS1-dynein complex resists detachment from microtubules under load ► NudE-LIS1 allow summation of multiple dynein forces for transport of high loads

19.

Reconstitution of the RIG-I Pathway Reveals a Signaling Role of Unanchored Polyubiquitin Chains in Innate Immunity
Pages 315-330
Wenwen Zeng, Lijun Sun, Xiaomo Jiang, Xiang Chen, Fajian Hou, Anirban Adhikari, Ming Xu, Zhijian J. Chen

Graphical Abstract

► In vitro reconstitution of the RIG-I pathway from viral RNA binding to IRF3 activation ► The tandem CARD domains of RIG-I bind to K63-polyubiquitin chains ► Unanchored K63-polyubiquitin chains potently activate RIG-I ► RIG-I activation requires sequential binding of RNA and K63-polyubiquitin chains

20.

TRP Channel Regulates EGFR Signaling in Hair Morphogenesis and Skin Barrier Formation
Pages 331-343
Xiping Cheng, Jie Jin, Lily Hu, Dongbiao Shen, Xian-ping Dong, Mohammad A. Samie, Jayne Knoff, Brian Eisinger, Mei-ling Liu, Susan M. Huang, Michael J. Caterina, Peter Dempsey, Lowell Evan Michael, Andrzej A. Dlugosz, Nancy C. Andrews, David E. Clapham, Haoxing Xu

Graphical Abstract

► Mice deficient in TRPV3, EGFR, or TGF-α exhibit wavy hair coat and curly whiskers ► Activation of EGFR leads to increased TRPV3 channel activity in keratinocytes ► Activation of TRPV3 channel stimulates TGF-α release in keratinocytes ► TRPV3 regulates transglutaminase activity and skin barrier formation

Theories

21.

An Evolutionarily Conserved Mechanism for Controlling the Efficiency of Protein Translation
Pages 344-354
Tamir Tuller, Asaf Carmi, Kalin Vestsigian, Sivan Navon, Yuval Dorfan, John Zaborske, Tao Pan, Orna Dahan, Itay Furman, Yitzhak Pilpel

Graphical Abstract

► The efficiency of translation is universally lower across the first ∼50 codons ► Evolutionary forces act to maintain this profile of translation elongation speed ► The profile is predictive of ribosome density for translation of yeast genes ► The ramp in efficiency may contribute to fitness and managing the cost of translation

22.

A Role for Codon Order in Translation Dynamics
Pages 355-367
Gina Cannarrozzi, Nicol N. Schraudolph, Mahamadou Faty, Peter von Rohr, Markus T. Friberg, Alexander C. Roth, Pedro Gonnet, Gaston Gonnet, Yves Barral

Graphical Abstract

► Successive codons for a given amino acid tend to employ the same tRNA ► This increases translation speed by allowing recycling of tRNA molecules ► Effect present in many organisms and across substantial distances between codons ► Predictive of rapid expression, suggests substantial tRNA channeling at the ribosome

Errata

23.

Sumoylation Silences the Plasma Membrane Leak K⁺ Channel K2P1
Page 368
Sindhu Rajan, Leigh D. Plant, Michael L. Rabin, Margaret H. Butler, Steve A.N. Goldstein

24.

An Atlas of Combinatorial Transcriptional Regulation in Mouse and Man
Page 369
Timothy Ravasi, Harukazu Suzuki, Carlo Vittorio Cannistraci, Shintaro Katayama, Vladimir B. Bajic, Kai Tan, Altuna Akalin, Sebastian Schmeier, Mutsumi Kanamori-Katayama, Nicolas Bertin, Piero Carninci, Carsten O. Daub, Alistair R.R. Forrest, Julian Gough, Sean Grimmond, Jung-Hoon Han, Takehiro Hashimoto, Winston Hide, Oliver Hofmann, Atanas Kamburov, Mandeep Kaur, Hideya Kawaji, Atsutaka Kubosaki, Timo Lassmann, Erik van Nimwegen, Cameron Ross MacPherson, Chihiro Ogawa, Aleksandar Radovanovic, Ariel Schwartz, Rohan D. Teasdale, Jesper Tegnér, Boris Lenhard, Sarah A. Teichmann, Takahiro Arakawa, Noriko Ninomiya, Kayoko Murakami, Michihira Tagami, Shiro Fukuda, Kengo Imamura, Chikatoshi Kai, Ryoko Ishihara, Yayoi Kitazume, Jun Kawai, David A. Hume, Trey Ideker, Yoshihide Hayashizaki

SnapShot

25.

SnapShot: DNA Polymerases II Mammals
Pages 370-370.e1
James J. Foti, Graham C. Walker

Send my e-mail in plain text format

Modify or Remove My Alerts

Access the ScienceDirect Info site if you have questions about this message or other features of this service.

This email has been sent to you by ScienceDirect, a division of Elsevier B.V., Radarweg 29, 1043 NX Amsterdam, The Netherlands, Tel.+31 20 485 3911.

ScienceDirect respects your privacy and does not disclose, rent or sell your personal information to any non-affiliated third parties without your consent, except as may be stated in the ScienceDirect online privacy policy.

By using email or alert services, you agree to comply with the ScienceDirect Terms and Conditions.

To unsubscribe to alert services, please go to the Alerts page.

Copyright © 2010 ScienceDirect. All rights reserved. Any unauthorized use, reproduction, or transfer of this message or its contents, in any medium, is strictly prohibited. ScienceDirect® is a registered trademark of Elsevier B.V.

Delivery Job ID: 11207:276423380:11205:234359324

Journal of Investigative Dermatology - Table of Contents alert Volume 130 Issue 5

2010-04-15T09:01:00.001-07:00

JOURNAL OF INVESTIGATIVE DERMATOLOGY

May 2010 Volume 130 Number 5, pp 1193 - 1472

--------------------------------------------------------------------------

Ultraviolet Light: A Workshop for the Skin Care Industry
May 18, 2010
Princeton, NJ
TRI/Princeton offers this 1-day workshop to provide a forum for experts
from various backgrounds who are focusing research efforts on UV.
Join us to develop a common base knowledge on the UV, UVA, photobiology,
measurements and research tools.
Registration is $995.

http://links.ealert.nature.com/ctt?kn=88&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0

--------------------------------------------------------------------------

Still the #1 journal in Dermatology*

Journal of Investigative Dermatology (JID) continues to publish the latest,
most important research in cutaneous biology and skin disease. Read a full
issue FREE online:
http://links.ealert.nature.com/ctt?kn=168&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0

*2008 Journal Citation Report (Thomson Reuters, 2009)

----------------------
EDITORIAL
----------------------
The Importance of the Coalition of Skin Diseases to Dermatologic Research
Paul R Bergstresser,
Article: http://links.ealert.nature.com/ctt?kn=187&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0
PDF: http://links.ealert.nature.com/ctt?kn=189&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0

Clinical Snippets
Article: http://links.ealert.nature.com/ctt?kn=185&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0
PDF: http://links.ealert.nature.com/ctt?kn=192&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0

Research Snippets
Article: http://links.ealert.nature.com/ctt?kn=190&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0
PDF: http://links.ealert.nature.com/ctt?kn=191&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0

Editors' Picks
Article: http://links.ealert.nature.com/ctt?kn=133&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0
PDF: http://links.ealert.nature.com/ctt?kn=132&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0

----------------------
JOURNAL CLUB
----------------------
The Multipotent Nature of Hair Bulge Cells
Ronald Sulewski and Robert S Kirsner
Article: http://links.ealert.nature.com/ctt?kn=135&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0
PDF: http://links.ealert.nature.com/ctt?kn=140&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0

----------------------
MEETING REPORT
----------------------
Montagna Symposium 2009: Genetic-Epigenetic Basis of Skin Diseases
Angela Christiano, Molly Kulesz-Martin and Jackie R Bickenbach
Article: http://links.ealert.nature.com/ctt?kn=143&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0
PDF: http://links.ealert.nature.com/ctt?kn=141&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0

----------------------
COMMENTARIES
----------------------
Human Hair Follicles: "Bulging" with Neural Crest-Like Stem Cells
Jeff Biernaskie
Abstract: http://links.ealert.nature.com/ctt?kn=146&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=54&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0
PDF: http://links.ealert.nature.com/ctt?kn=55&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0

Lipids to the Top of Hair Biology
Kurt S Stenn and Pratima Karnik
Abstract: http://links.ealert.nature.com/ctt?kn=56&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=57&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0
PDF: http://links.ealert.nature.com/ctt?kn=58&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0

Interpretation of Quality-of-Life Scores
Mary-Margaret Chren
Abstract: http://links.ealert.nature.com/ctt?kn=60&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=62&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0
PDF: http://links.ealert.nature.com/ctt?kn=63&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0

Common Links among the Pathways Leading to UV-Induced Immunosuppression
Gary M. Halliday
Abstract: http://links.ealert.nature.com/ctt?kn=64&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=65&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0
PDF: http://links.ealert.nature.com/ctt?kn=68&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0

----------------------
REVIEW
----------------------
Molecular Dissection of Psoriasis: Integrating Genetics and Biology
James T Elder, Allen T Bruce, Johann E Gudjonsson, Andrew Johnston, Philip E Stuart,
Trilokraj Tejasvi, John J Voorhees, Goncalo R Abecasis and Rajan P Nair
Abstract: http://links.ealert.nature.com/ctt?kn=71&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=72&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0
PDF: http://links.ealert.nature.com/ctt?kn=69&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0

----------------------
ORIGINAL ARTICLES
----------------------

Stem Cells with Neural Crest Characteristics Derived from the Bulge Region of Cultured Human Hair Follicles
Hong Yu, Suresh M Kumar, Andrew V Kossenkov, Louise Showe and Xiaowei Xu
Abstract: http://links.ealert.nature.com/ctt?kn=70&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=77&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0
PDF: http://links.ealert.nature.com/ctt?kn=79&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0

Hair Growth Defects in Insig-Deficient Mice Caused by Cholesterol Precursor Accumulation
and Reversed by Simvastatin
Bret M Evers, Midhat S Farooqi, John M Shelton, James A Richardson, Joseph L Goldstein,
Michael S Brown and Guosheng Liang
Abstract: http://links.ealert.nature.com/ctt?kn=73&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=75&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0
PDF: http://links.ealert.nature.com/ctt?kn=81&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0

CELL BIOLOGY
Transcriptional Repression of miR-34 Family Contributes to p63-Mediated Cell Cycle
Progression in Epidermal Cells
Dario Antonini, Monia T Russo, Laura De Rosa, Marisa Gorrese, Luigi Del Vecchio and Caterina Missero
Abstract: http://links.ealert.nature.com/ctt?kn=91&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=89&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0
PDF: http://links.ealert.nature.com/ctt?kn=97&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0

Effects of the Aminophenol Analogue p-Dodecylaminophenol on Mouse Skin
Noriko Takahashi and Yasunori Fujiu
Abstract: http://links.ealert.nature.com/ctt?kn=98&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=99&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0
PDF: http://links.ealert.nature.com/ctt?kn=100&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0

Real-Time Monitoring of Membrane Cholesterol Reveals New Insights into Epidermal Differentiation
Florian Sporl, Minetta Wunderskirchner, Oliver Ullrich, Gerrit Bomke, Ute Breitenbach,
Thomas Blatt, Horst Wenck, Klaus-Peter Wittern and Annika Schrader
Abstract: http://links.ealert.nature.com/ctt?kn=92&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=93&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0
PDF: http://links.ealert.nature.com/ctt?kn=95&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0

Soluble Adenylyl Cyclase Defines a Nuclear cAMP Microdomain in Keratinocyte Hyperproliferative Skin Diseases
Jonathan H Zippin, Paul A Chadwick, Lonny R Levin, Jochen Buck and Cynthia M Magro
Abstract: http://links.ealert.nature.com/ctt?kn=96&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=107&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0
PDF: http://links.ealert.nature.com/ctt?kn=109&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0

Overexpression of Fetuin-A Counteracts Ectopic Mineralization in a Mouse Model of
Pseudoxanthoma Elasticum (Abcc6-/-)
Qiujie Jiang, Florian Dibra, Michael D Lee, Reid Oldenburg and Jouni Uitto
Abstract: http://links.ealert.nature.com/ctt?kn=108&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=116&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0
PDF: http://links.ealert.nature.com/ctt?kn=117&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0

Kallikrein Expression and Cathelicidin Processing Are Independently Controlled in Keratinocytes
by Calcium, Vitamin D3, and Retinoic Acid
Shin Morizane, Kenshi Yamasaki, Filamer D Kabigting and Richard L Gallo
Abstract: http://links.ealert.nature.com/ctt?kn=114&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=115&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0
PDF: http://links.ealert.nature.com/ctt?kn=112&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0

Angiopoietin-1 Reduces H2O2-Induced Increases in Reactive Oxygen Species and Oxidative Damage to Skin Cells
Nesreen S Ismail, Elke A Pravda, Dan Li, Shou-Ching Shih and Susan M Dallabrida
Abstract: http://links.ealert.nature.com/ctt?kn=113&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=110&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0
PDF: http://links.ealert.nature.com/ctt?kn=126&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0

CLINICAL RESEARCH
Health-Related Quality of Life Assessment in Dermatology: Interpretation of Skindex-29 Scores
Using Patient-Based Anchors
Cecilia A C Prinsen, Robert Lindeboom, Mirjam A G Sprangers, Catharina M Legierse and John de Korte
Abstract: http://links.ealert.nature.com/ctt?kn=125&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=124&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0
PDF: http://links.ealert.nature.com/ctt?kn=123&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0

Incidence Trends of Squamous Cell and Rare Skin Cancers in the Swedish National Cancer
Registry Point to Calendar Year and Age-Dependent Increases
Shehnaz K Hussain, Jan Sundquist and Kari Hemminki
Abstract: http://links.ealert.nature.com/ctt?kn=6&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=4&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0
PDF: http://links.ealert.nature.com/ctt?kn=8&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0

IMMUNOLOGY/INFECTION
T Cells Specific to Leishmania and Other Nonrelated Microbial Antigens Can Migrate to Human
Leishmaniasis Skin Lesions
Alda M Da-Cruz, Manoel P Oliveira-Neto, Alvaro L Bertho, Carolina O Mendes-Aguiar and Sergio G Coutinho
Abstract: http://links.ealert.nature.com/ctt?kn=7&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=10&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0
PDF: http://links.ealert.nature.com/ctt?kn=9&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0

[mu]-Opioid Receptor Is Induced by IL-13 within Lymph Nodes from Patients with Sezary Syndrome
Alan Benard, Pierre Cavailles, Jerome Boue, Emmanuelle Chapey, Jagadeesh Bayry, Catherine Blanpied,
Nicolas Meyer, Laurence Lamant, Srini V Kaveri, Pierre Brousset and Gilles Dietrich
Abstract: http://links.ealert.nature.com/ctt?kn=11&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=12&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0
PDF: http://links.ealert.nature.com/ctt?kn=13&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0

Human Langerhans Cells Are More Efficient Than CD14-CD1c+ Dermal Dendritic Cells at Priming Naive CD4+ T Cells
Laetitia Furio, Isabelle Briotet, Alexandra Journeaux, Hermine Billard and Josette Peguet-Navarro
Abstract: http://links.ealert.nature.com/ctt?kn=14&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=16&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0
PDF: http://links.ealert.nature.com/ctt?kn=23&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0

Enhanced Expression and Secretion of Antimicrobial Peptides in Atopic Dermatitis and after
Superficial Skin Injury
Jurgen Harder, Stefanie Dressel, Maike Wittersheim, Jesko Cordes, Ulf Meyer-Hoffert,
Ulrich Mrowietz, Regina Folster-Holst, Ehrhard Proksch, Jens-Michael Schroder, Thomas Schwarz and Regine Glaser
Abstract: http://links.ealert.nature.com/ctt?kn=22&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=20&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0
PDF: http://links.ealert.nature.com/ctt?kn=18&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0

Erysipelas Caused by Group A Streptococcus Activates the Contact System and Induces the
Release of Heparin-Binding Protein
Adam Linder, Linda Johansson, Pontus Thulin, Erika Hertzen, Matthias Morgelin,
Bertil Christensson, Lars Bjorck, Anna Norrby-Teglund and Per Akesson
Abstract: http://links.ealert.nature.com/ctt?kn=26&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=28&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0
PDF: http://links.ealert.nature.com/ctt?kn=29&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0

Circulating Th17, Th22, and Th1 Cells Are Increased in Psoriasis
Shinji Kagami, Heather L Rizzo, Jennifer J Lee, Yoshinobu Koguchi and Andrew Blauvelt
Abstract: http://links.ealert.nature.com/ctt?kn=32&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=33&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0
PDF: http://links.ealert.nature.com/ctt?kn=30&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0

Regulation of the Psoriatic Chemokine CCL20 by E3 Ligases Trim32 and Piasy in Keratinocytes
Yuangang Liu, James P Lagowski, Shangpu Gao, James H Raymond, Clifton R White and Molly F Kulesz-Martin
Abstract: http://links.ealert.nature.com/ctt?kn=31&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=36&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0
PDF: http://links.ealert.nature.com/ctt?kn=35&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0

KERATINOCYTES/EPIDERMIS
Autoantibodies in Scurfy Mice and IPEX Patients Recognize Keratin 14
Eva N Huter, Kannan Natarajan, Troy R Torgerson, Deborah D Glass and Ethan M Shevach
Abstract: http://links.ealert.nature.com/ctt?kn=40&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=38&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0
PDF: http://links.ealert.nature.com/ctt?kn=45&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0

MELANOCYTES/MELANOMA
Induction of Terminal Differentiation in Melanoma Cells on Downregulation of [beta]-Amyloid Precursor Protein
Michelle G Botelho, Xiaolei Wang, Donna J Arndt-Jovin, Dorothea Becker and Thomas M Jovin
Abstract: http://links.ealert.nature.com/ctt?kn=46&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=47&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0
PDF: http://links.ealert.nature.com/ctt?kn=41&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0

PHOTOBIOLOGY
Recommended Summer Sunlight Exposure Levels Can Produce Sufficient ([ges]20[thinsp]ng[thinsp]ml-1)
but Not the Proposed Optimal ([ges]32[thinsp]ng[thinsp]ml-1) 25(OH)D Levels at UK Latitudes
Lesley E Rhodes, Ann R Webb, Heather I Fraser, Richard Kift, Marie T Durkin, Donald Allan,
Sarah J O'Brien, Andy Vail and Jacqueline L Berry
Abstract: http://links.ealert.nature.com/ctt?kn=42&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=43&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0
PDF: http://links.ealert.nature.com/ctt?kn=44&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0

Langerhans Cells Are Required for UVR-Induced Immunosuppression
Agatha Schwarz, Madelon Noordegraaf, Akira Maeda, Kan Torii, Bjorn E Clausen and Thomas Schwarz
Abstract: http://links.ealert.nature.com/ctt?kn=52&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=51&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0
PDF: http://links.ealert.nature.com/ctt?kn=50&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0

Agents that Reverse UV-Induced Immune Suppression and Photocarcinogenesis Affect DNA Repair
Coimbatore S Sreevidya, Atsushi Fukunaga, Noor M Khaskhely, Taro Masaki, Ryusuke Ono,
Chikako Nishigori and Stephen E Ullrich
Abstract: http://links.ealert.nature.com/ctt?kn=128&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=149&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0
PDF: http://links.ealert.nature.com/ctt?kn=148&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0

TUMOR BIOLOGY
Association of Prediagnostic Serum Vitamin D Levels with the Development of Basal Cell Carcinoma
Maryam M Asgari, Jean Tang, Margaret E Warton, Mary-Margaret Chren, Charles P Quesenberry,
Dan Bikle, Ronald L Horst, Norman Orentreich, Joseph H Vogelman and Gary D Friedman
Abstract: http://links.ealert.nature.com/ctt?kn=151&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=150&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0
PDF: http://links.ealert.nature.com/ctt?kn=144&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0

WOUND HEALING
Basic Fibroblast Growth Factor Regulates Persistent ERK Oscillations in Premalignant but Not Malignant JB6 Cells
Thomas J Weber, Harish Shankaran, H Steven Wiley, Lee K Opresko, William B Chrisler and Ryan D Quesenberry
Abstract: http://links.ealert.nature.com/ctt?kn=142&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=147&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0
PDF: http://links.ealert.nature.com/ctt?kn=145&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0

----------------------
LETTERS TO THE EDITOR
----------------------
Lipid Rafts and the Oxidative Stress Hypothesis
Conny Mathay and Yves Poumay
Article: http://links.ealert.nature.com/ctt?kn=197&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0
PDF: http://links.ealert.nature.com/ctt?kn=196&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0

Tannic Acid and Quercetin Display a Therapeutic Effect in Atopic Dermatitis via Suppression
of Angiogenesis and TARC Expression in Nc/Nga Mice
Min Kyung Jung, Dae Young Hur, Seok Bean Song, Yoorim Park, Tae Sung Kim, Sa Ik Bang,
Seonghan Kim, Hyun Keun Song, Hyunjeong Park and Dae Ho Cho
Article: http://links.ealert.nature.com/ctt?kn=203&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0
PDF: http://links.ealert.nature.com/ctt?kn=199&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0

Relationship between Germline MC1R Variants and BRAF-Mutant Melanoma in a North Carolina Population-Based Study
Nancy E Thomas, Peter A Kanetsky, Sharon N Edmiston, Audrey Alexander, Colin B Begg,
Pamela A Groben, Honglin Hao, Klaus Busam, David W Ollila, Marianne Berwick and Kathleen Conway
Article: http://links.ealert.nature.com/ctt?kn=206&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0
PDF: http://links.ealert.nature.com/ctt?kn=207&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0

PAX3 Is Extensively Expressed in Benign and Malignant Tissues of the Melanocytic Lineage in Humans
Shujie He, Han-Seung Yoon, Bong-Jik Suh and Michael R Eccles
Abstract: http://links.ealert.nature.com/ctt?kn=204&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=205&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0
PDF: http://links.ealert.nature.com/ctt?kn=177&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0

Cathepsin S Elicits Itch and Signals via Protease-Activated Receptors
Vemuri B Reddy, Steven G Shimada, Parul Sikand, Robert H LaMotte and Ethan A Lerner
Article: http://links.ealert.nature.com/ctt?kn=179&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0
PDF: http://links.ealert.nature.com/ctt?kn=181&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0

IRF4 Expression without IRF4 Rearrangement Is a General Feature of Primary Cutaneous
Diffuse Large B-Cell Lymphoma, Leg Type
Anne Pham-Ledard, Martina Prochazkova-Carlotti, Beatrice Vergier, Tony Petrella,
Florent Grange, Marie Beylot-Barry and Jean-Philippe Merlio for the French Study Group of Cutaneous Lymphoma
Article: http://links.ealert.nature.com/ctt?kn=186&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0
PDF: http://links.ealert.nature.com/ctt?kn=188&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0

--------------------------------------------------------------------------

Free for everyone. JID Editorials, Clinical Snippets and Editors' Picks
are too good to keep to only our subscribers. Did you know that these
articles are always available to everyone? Visit the journal online for
the latest on cutaneous biology and learn why JID is the #1 journal in
dermatology.

http://links.ealert.nature.com/ctt?kn=122&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0

=====================================================================

You have been sent this Table of Contents Alert because you have opted in to receive it.
You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at:
http://links.ealert.nature.com/ctt?kn=48&m=34788513&r=MTc2MjcyNDA3NwS2&b=2&j=NzIwMzY1ODgS1&mt=1&rt=0
(You will need to log in to be recognised as a nature.com registrant).

For further technical assistance, please contact our registration department:
registration@nature.com

For print subscription enquiries, please contact our subscription department:
subscriptions@nature.com

For other enquiries, please contact customer feedback department:
feedback@nature.com

Nature Publishing Group | 75 Varick Street, 9th Floor | New York | NY 10013-1917 | USA

Nature Publishing Group's worldwide offices:
London - Paris - Munich - New Delhi - Tokyo - Melbourne - San Diego - San Francisco - Washington - New York - Boston

=====================================================================

physics@nature.com 15 April 2010

2010-04-15T08:04:00.001-07:00

*********************************
physics@nature.com
*********************************

WOULD YOU PREFER TO RECEIVE THIS ALERT IN HTML FORMAT?
Tell us at http://links.ealert.nature.com/ctt?kn=88&m=34788156&r=MTc2ODM1MzAwNQS2&b=2&j=NzIwMzM2MzIS1&mt=1&rt=0

*********************************************************************
Bringing you the latest and best in physics news and research from
Nature Publishing Group

For more information, see each journal's latest table of contents:

Nature Volume 464 Number 7291 pp 957-1094
http://links.ealert.nature.com/ctt?kn=13&m=34788156&r=MTc2ODM1MzAwNQS2&b=2&j=NzIwMzM2MzIS1&mt=1&rt=0

Nature Physics Volume 6 Number 4 pp 231-316
http://links.ealert.nature.com/ctt?kn=54&m=34788156&r=MTc2ODM1MzAwNQS2&b=2&j=NzIwMzM2MzIS1&mt=1&rt=0

Nature Materials Volume 9 Number 4 pp 281-368
http://links.ealert.nature.com/ctt?kn=112&m=34788156&r=MTc2ODM1MzAwNQS2&b=2&j=NzIwMzM2MzIS1&mt=1&rt=0

Nature Nanotechnology Volume 5 Number 4 pp 237-309
http://links.ealert.nature.com/ctt?kn=51&m=34788156&r=MTc2ODM1MzAwNQS2&b=2&j=NzIwMzM2MzIS1&mt=1&rt=0

Nature Photonics Volume 4 Number 4 pp 195-258
http://links.ealert.nature.com/ctt?kn=99&m=34788156&r=MTc2ODM1MzAwNQS2&b=2&j=NzIwMzM2MzIS1&mt=1&rt=0

=========================== ADVERTISEMENT ===========================

Free to view: digital edition of Nature Photonics Technology Focus

Newly available as a digital edition, see for yourself if the Nature
Photonics Technology Focus is right for you. January and March issues
are free to view here
http://links.ealert.nature.com/ctt?kn=52&m=34788156&r=MTc2ODM1MzAwNQS2&b=2&j=NzIwMzM2MzIS1&mt=1&rt=0

Like what you see. Register here today for your FREE subscription!
http://links.ealert.nature.com/ctt?kn=139&m=34788156&r=MTc2ODM1MzAwNQS2&b=2&j=NzIwMzM2MzIS1&mt=1&rt=0

======================================================================

-------------------------------
Editorials
-------------------------------

Winners take all
http://links.ealert.nature.com/ctt?kn=81&m=34788156&r=MTc2ODM1MzAwNQS2&b=2&j=NzIwMzM2MzIS1&mt=1&rt=0

Welcome Nature Communications
http://links.ealert.nature.com/ctt?kn=84&m=34788156&r=MTc2ODM1MzAwNQS2&b=2&j=NzIwMzM2MzIS1&mt=1&rt=0

-------------------------------
News
-------------------------------

US nuclear policy could boost basic research
http://links.ealert.nature.com/ctt?kn=111&m=34788156&r=MTc2ODM1MzAwNQS2&b=2&j=NzIwMzM2MzIS1&mt=1&rt=0

Japan rolls out elite science funds
http://links.ealert.nature.com/ctt?kn=121&m=34788156&r=MTc2ODM1MzAwNQS2&b=2&j=NzIwMzM2MzIS1&mt=1&rt=0

-------------------------------
Column
-------------------------------

Moment of reckoning
http://links.ealert.nature.com/ctt?kn=116&m=34788156&r=MTc2ODM1MzAwNQS2&b=2&j=NzIwMzM2MzIS1&mt=1&rt=0

-------------------------------
Correspondence
-------------------------------

Weighing up the case for telescope site on La Palma
http://links.ealert.nature.com/ctt?kn=79&m=34788156&r=MTc2ODM1MzAwNQS2&b=2&j=NzIwMzM2MzIS1&mt=1&rt=0

-------------------------------
Books and Arts
-------------------------------

Beyond the image of the tragic genius
http://links.ealert.nature.com/ctt?kn=60&m=34788156&r=MTc2ODM1MzAwNQS2&b=2&j=NzIwMzM2MzIS1&mt=1&rt=0

Q&A: John Sims on mathematical art
http://links.ealert.nature.com/ctt?kn=62&m=34788156&r=MTc2ODM1MzAwNQS2&b=2&j=NzIwMzM2MzIS1&mt=1&rt=0

-------------------------------
News and Views
-------------------------------

Complex networks: The fragility of interdependency
http://links.ealert.nature.com/ctt?kn=65&m=34788156&r=MTc2ODM1MzAwNQS2&b=2&j=NzIwMzM2MzIS1&mt=1&rt=0

Information science: Guaranteed randomness
http://links.ealert.nature.com/ctt?kn=67&m=34788156&r=MTc2ODM1MzAwNQS2&b=2&j=NzIwMzM2MzIS1&mt=1&rt=0

-------------------------------
Letters
-------------------------------

An image of an exoplanet separated by two diffraction beamwidths from
a star
E. Serabyn, D. Mawet & R. Burruss
http://links.ealert.nature.com/ctt?kn=45&m=34788156&r=MTc2ODM1MzAwNQS2&b=2&j=NzIwMzM2MzIS1&mt=1&rt=0

Random numbers certified by Bell's theorem
S. Pironio et al.
http://links.ealert.nature.com/ctt?kn=43&m=34788156&r=MTc2ODM1MzAwNQS2&b=2&j=NzIwMzM2MzIS1&mt=1&rt=0

Catastrophic cascade of failures in interdependent networks
Sergey V. Buldyrev et al.
http://links.ealert.nature.com/ctt?kn=35&m=34788156&r=MTc2ODM1MzAwNQS2&b=2&j=NzIwMzM2MzIS1&mt=1&rt=0

Delocalization of a disordered bosonic system by repulsive
interactions
B. Deissler et al.
http://links.ealert.nature.com/ctt?kn=131&m=34788156&r=MTc2ODM1MzAwNQS2&b=2&j=NzIwMzM2MzIS1&mt=1&rt=0

Direct observation of magnetic monopole defects in an artificial
spin-ice system
S. Ladak, D. E. Read, G. K. Perkins, L. F. Cohen & W. R. Branford
http://links.ealert.nature.com/ctt?kn=127&m=34788156&r=MTc2ODM1MzAwNQS2&b=2&j=NzIwMzM2MzIS1&mt=1&rt=0

Understanding amyloid aggregation by statistical analysis of atomic
force microscopy images
Jozef Adamcik et al.
http://links.ealert.nature.com/ctt?kn=2&m=34788156&r=MTc2ODM1MzAwNQS2&b=2&j=NzIwMzM2MzIS1&mt=1&rt=0

Observation and control of blinking nitrogen-vacancy centres in
discrete nanodiamonds
C. Bradac et al.
http://links.ealert.nature.com/ctt?kn=143&m=34788156&r=MTc2ODM1MzAwNQS2&b=2&j=NzIwMzM2MzIS1&mt=1&rt=0

-------------------------------
Articles
-------------------------------

Why do particle clouds generate electric charges?
T. P�htz, H. J. Herrmann & T. Shinbrot
http://links.ealert.nature.com/ctt?kn=126&m=34788156&r=MTc2ODM1MzAwNQS2&b=2&j=NzIwMzM2MzIS1&mt=1&rt=0

=========================== ADVERTISEMENT ===========================

Nature Insight Exotic matter

Bring together a large number of particles, and they can order
themselves in unusual ways, giving rise to emergent phenomena that
cannot be understood solely in terms of the interactions that rule
at the microscopic level. This Insight exposes examples of matter for
which the maxim 'more is different' holds true in particularly
striking ways.

Access selected content free online
http://links.ealert.nature.com/ctt?kn=82&m=34788156&r=MTc2ODM1MzAwNQS2&b=2&j=NzIwMzM2MzIS1&mt=1&rt=0

=====================================================================

You have been sent this Table of Contents Alert because you have
opted in to receive it. You can change or discontinue your e-mail
alerts at any time, by modifying your preferences on your
nature.com account at: http://links.ealert.nature.com/ctt?kn=96&m=34788156&r=MTc2ODM1MzAwNQS2&b=2&j=NzIwMzM2MzIS1&mt=1&rt=0
(You will need to log in to be recognised as a nature.com registrant)

For further technical assistance, please contact our registration
department: mailto:registration@nature.com

For print subscription enquiries, please contact our subscription
department: mailto:subscriptions@nature.com

For other enquiries, please contact our customer feedback department:
mailto:feedback@nature.com

Nature Publishing Group * 75 Varick Street, 9th floor * New York *
NY 10013-1917 * USA

Nature Publishing Group's worldwide offices:
London - Paris - Munich - New Delhi - Tokyo - Melbourne
San Diego - San Francisco - Washington - New York - Boston

=====================================================================

Kidney International - Table of Contents alert Volume 77 Issue 9

2010-04-15T04:27:00.001-07:00

KIDNEY INTERNATIONAL

May 2010 Volume 77 Number 9, pp 747 - 836

====ADVERTISEMENT=====

RBM's KidneyMAPs detect drug toxicity earlier
and with more sensitivity than BUN and creatinine.
Developed in response to the FDA's Critical Path
Initiative, these powerful assays measure critical
renal biomarkers (12 rat & 16 human).
Download our scientific posters & receive 10% off your order
http://links.ealert.nature.com/ctt?kn=82&m=34787080&r=MTc2MzAwNDQzNwS2&b=2&j=NzIwMjQ1NDcS1&mt=1&rt=0

----------------------

====ADVERTISEMENT=====

NEW from KI: the Kidney Podcast! Visit
http://links.ealert.nature.com/ctt?kn=103&m=34787080&r=MTc2MzAwNDQzNwS2&b=2&j=NzIwMjQ1NDcS1&mt=1&rt=0 today!
To listen as top researchers discuss their work with KI Editors, visit
http://links.ealert.nature.com/ctt?kn=15&m=34787080&r=MTc2MzAwNDQzNwS2&b=2&j=NzIwMjQ1NDcS1&mt=1&rt=0

----------------------

----------------------
IN THIS ISSUE
----------------------
In this Issue
http://links.ealert.nature.com/ctt?kn=58&m=34787080&r=MTc2MzAwNDQzNwS2&b=2&j=NzIwMjQ1NDcS1&mt=1&rt=0

----------------------
EDITORIAL
----------------------
Choosing the right mouse model for diabetic nephropathy
Detlef Schlöndorff
http://links.ealert.nature.com/ctt?kn=66&m=34787080&r=MTc2MzAwNDQzNwS2&b=2&j=NzIwMjQ1NDcS1&mt=1&rt=0

----------------------
JOURNAL CLUB
----------------------
Journal Club
http://links.ealert.nature.com/ctt?kn=70&m=34787080&r=MTc2MzAwNDQzNwS2&b=2&j=NzIwMjQ1NDcS1&mt=1&rt=0

----------------------
COMMENTARIES
----------------------
Hypertension, chronic kidney disease, and the development of cardiovascular risk: a joint primacy
John P Middleton and Patrick H Pun
Abstract: http://links.ealert.nature.com/ctt?kn=74&m=34787080&r=MTc2MzAwNDQzNwS2&b=2&j=NzIwMjQ1NDcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=60&m=34787080&r=MTc2MzAwNDQzNwS2&b=2&j=NzIwMjQ1NDcS1&mt=1&rt=0

The promise of biomarkers for personalized renal cancer care
Prasad Devarajan
Abstract: http://links.ealert.nature.com/ctt?kn=62&m=34787080&r=MTc2MzAwNDQzNwS2&b=2&j=NzIwMjQ1NDcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=64&m=34787080&r=MTc2MzAwNDQzNwS2&b=2&j=NzIwMjQ1NDcS1&mt=1&rt=0

LECT2 amyloidosis
Merrill D Benson
Abstract: http://links.ealert.nature.com/ctt?kn=14&m=34787080&r=MTc2MzAwNDQzNwS2&b=2&j=NzIwMjQ1NDcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=12&m=34787080&r=MTc2MzAwNDQzNwS2&b=2&j=NzIwMjQ1NDcS1&mt=1&rt=0

----------------------
MINI REVIEWS
----------------------
Recent changes in vancomycin use in renal failure
Stefaan J Vandecasteele and An S De Vriese
Abstract: http://links.ealert.nature.com/ctt?kn=11&m=34787080&r=MTc2MzAwNDQzNwS2&b=2&j=NzIwMjQ1NDcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=10&m=34787080&r=MTc2MzAwNDQzNwS2&b=2&j=NzIwMjQ1NDcS1&mt=1&rt=0

Membranous nephropathy: recent travels and new roads ahead
Laurence H Beck and David J Salant
Abstract: http://links.ealert.nature.com/ctt?kn=9&m=34787080&r=MTc2MzAwNDQzNwS2&b=2&j=NzIwMjQ1NDcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=7&m=34787080&r=MTc2MzAwNDQzNwS2&b=2&j=NzIwMjQ1NDcS1&mt=1&rt=0

----------------------
ORIGINAL ARTICLES
----------------------
Regulatory T cells contribute to the protective effect of ischemic preconditioning in the kidney
Gilbert R Kinsey, Liping Huang, Amy L Vergis, Li Li and Mark D Okusa
Abstract: http://links.ealert.nature.com/ctt?kn=99&m=34787080&r=MTc2MzAwNDQzNwS2&b=2&j=NzIwMjQ1NDcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=96&m=34787080&r=MTc2MzAwNDQzNwS2&b=2&j=NzIwMjQ1NDcS1&mt=1&rt=0

Differential resolution of inflammation and recovery after renal ischemia-reperfusion injury in Brown Norway compared with Sprague Dawley rats
David Sáenz-Morales, Elisa Conde, Ignacio Blanco-Sánchez, Belen Ponte, Elia Aguado-Fraile, Gonzalo de las Casas, Maria García-Martos, Laura Alegre, Maria M Escribese, Ana Molina, Carmen Santiuste, Fernando Liaño and Maria-Laura García-Bermejo
Abstract: http://links.ealert.nature.com/ctt?kn=101&m=34787080&r=MTc2MzAwNDQzNwS2&b=2&j=NzIwMjQ1NDcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=100&m=34787080&r=MTc2MzAwNDQzNwS2&b=2&j=NzIwMjQ1NDcS1&mt=1&rt=0

Higher systolic blood pressure is associated with progression of carotid intima-media thickness in patients with chronic kidney disease
Jessica Kendrick, Michel Chonchol, Hannes Gnahn and Dirk Sander
Abstract: http://links.ealert.nature.com/ctt?kn=86&m=34787080&r=MTc2MzAwNDQzNwS2&b=2&j=NzIwMjQ1NDcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=87&m=34787080&r=MTc2MzAwNDQzNwS2&b=2&j=NzIwMjQ1NDcS1&mt=1&rt=0

The chemokine receptor CXCR7 is expressed on lymphatic endothelial cells during renal allograft rejection
Matthias A Neusser, Anna K Kraus, Heinz Regele, Clemens D Cohen, Thomas Fehr, Dontscho Kerjaschki, Rudolf P Wüthrich, Mark E T Penfold, Thomas Schall and Stephan Segerer
Abstract: http://links.ealert.nature.com/ctt?kn=88&m=34787080&r=MTc2MzAwNDQzNwS2&b=2&j=NzIwMjQ1NDcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=89&m=34787080&r=MTc2MzAwNDQzNwS2&b=2&j=NzIwMjQ1NDcS1&mt=1&rt=0

Predictive value of baseline serum vascular endothelial growth factor and neutrophil gelatinase-associated lipocalin in advanced kidney cancer patients receiving sunitinib
Camillo Porta, Chiara Paglino, Mara De Amici, Silvana Quaglini, Lucia Sacchi, Ilaria Imarisio and Cinzia Canipari
Abstract: http://links.ealert.nature.com/ctt?kn=91&m=34787080&r=MTc2MzAwNDQzNwS2&b=2&j=NzIwMjQ1NDcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=92&m=34787080&r=MTc2MzAwNDQzNwS2&b=2&j=NzIwMjQ1NDcS1&mt=1&rt=0

Prevalence and morphology of leukocyte chemotactic factor 2-associated amyloid in renal biopsies
Christopher P Larsen, Patrick D Walker, Deborah T Weiss and Alan Solomon
Abstract: http://links.ealert.nature.com/ctt?kn=94&m=34787080&r=MTc2MzAwNDQzNwS2&b=2&j=NzIwMjQ1NDcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=126&m=34787080&r=MTc2MzAwNDQzNwS2&b=2&j=NzIwMjQ1NDcS1&mt=1&rt=0

Tubulointerstitial lesions of patients with lupus nephritis classified by the 2003 International Society of Nephrology and Renal Pathology Society system
Feng Yu, Li-hua Wu, Ying Tan, Li-hua Li, Cai-li Wang, Wen-ke Wang, Zhen Qu, Meng-hua Chen, Jun-jie Gao, Zeng-yan Li, Xin Zheng, Jie Ao, Sai-nan Zhu, Su-xia Wang, Ming-hui Zhao, Wan-zhong Zou and Gang Liu
Abstract: http://links.ealert.nature.com/ctt?kn=125&m=34787080&r=MTc2MzAwNDQzNwS2&b=2&j=NzIwMjQ1NDcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=123&m=34787080&r=MTc2MzAwNDQzNwS2&b=2&j=NzIwMjQ1NDcS1&mt=1&rt=0

----------------------
LETTERS TO THE EDITOR
----------------------
Connecting continuous renal replacement therapy in parallel with extracorporeal membrane oxygenation: is there no problem?
Chiao-Lin Chuang and Wu-Chang Yang
http://links.ealert.nature.com/ctt?kn=113&m=34787080&r=MTc2MzAwNDQzNwS2&b=2&j=NzIwMjQ1NDcS1&mt=1&rt=0

The Authors Reply
Jesús López-Herce, Maria Jose Santiago and Amelia Sánchez
http://links.ealert.nature.com/ctt?kn=110&m=34787080&r=MTc2MzAwNDQzNwS2&b=2&j=NzIwMjQ1NDcS1&mt=1&rt=0

Localization and mechanism of nephrocalcinosis in pseudo-Bartter's syndrome
Akihiro Tojo, Kana Unuma, Kazuki Harada, Ken-ichi Yoshida and Toshiro Fujita
http://links.ealert.nature.com/ctt?kn=122&m=34787080&r=MTc2MzAwNDQzNwS2&b=2&j=NzIwMjQ1NDcS1&mt=1&rt=0

The Authors Reply:
Benjamin A Vervaet, Anja Verhulst, Marc E De Broe and Patrick C D'Haese
http://links.ealert.nature.com/ctt?kn=120&m=34787080&r=MTc2MzAwNDQzNwS2&b=2&j=NzIwMjQ1NDcS1&mt=1&rt=0

Targeting mineralocorticoid (-like) interventions to treat hyperkalemia in chronic hemodialysis patients
William R Adam
http://links.ealert.nature.com/ctt?kn=53&m=34787080&r=MTc2MzAwNDQzNwS2&b=2&j=NzIwMjQ1NDcS1&mt=1&rt=0

The Authors Reply:
Stefan Farese and Felix J Frey
http://links.ealert.nature.com/ctt?kn=49&m=34787080&r=MTc2MzAwNDQzNwS2&b=2&j=NzIwMjQ1NDcS1&mt=1&rt=0

Vasopressin and microalbuminuria: is it vasopressin per se or is it salt intake?
Esther Meijer, Paul E de Jong and Ron T Gansevoort
http://links.ealert.nature.com/ctt?kn=51&m=34787080&r=MTc2MzAwNDQzNwS2&b=2&j=NzIwMjQ1NDcS1&mt=1&rt=0

Psychological risk factors of kidney transplant patients
Helge Müller, Wilfried Gwinner, Horst Haltenhof, Johannes Kornhuber and Juan Manuel Maler
http://links.ealert.nature.com/ctt?kn=42&m=34787080&r=MTc2MzAwNDQzNwS2&b=2&j=NzIwMjQ1NDcS1&mt=1&rt=0

----------------------
CORRIGENDUM/ERRATUM
----------------------
Depressed expression of Klotho and FGF receptor 1 in hyperplastic parathyroid glands from uremic patients
http://links.ealert.nature.com/ctt?kn=45&m=34787080&r=MTc2MzAwNDQzNwS2&b=2&j=NzIwMjQ1NDcS1&mt=1&rt=0

Tubulogenesis controls cell specification
http://links.ealert.nature.com/ctt?kn=77&m=34787080&r=MTc2MzAwNDQzNwS2&b=2&j=NzIwMjQ1NDcS1&mt=1&rt=0

----------------------
NEPHROLOGY IMAGE
----------------------
Vegetation in the superior vena cava: a complication of tunneled dialysis catheters
Tze-Fan Chao, Su-Jung Chen, Shuenn-Jiin Ho, Shih-Hsien Sung and Wen-Chung Yu
http://links.ealert.nature.com/ctt?kn=57&m=34787080&r=MTc2MzAwNDQzNwS2&b=2&j=NzIwMjQ1NDcS1&mt=1&rt=0

====ADVERTISEMENT=====

Nexus:
ISN Nexus, Fibrosis and the Kidney: Emerging culprits in Pathogenesis
and advances in therapy - 30 June - 3 July 2010 Geneva, Switzerland.
http://links.ealert.nature.com/ctt?kn=20&m=34787080&r=MTc2MzAwNDQzNwS2&b=2&j=NzIwMjQ1NDcS1&mt=1&rt=0

----------------------

====ADVERTISEMENT=====

Articles for Kidney International are published online ahead of print
through Advance Online Publication (AOP), meaning that the latest research
reaches you in the timeliest way possible. Check the AOP webpage each week at
http://links.ealert.nature.com/ctt?kn=73&m=34787080&r=MTc2MzAwNDQzNwS2&b=2&j=NzIwMjQ1NDcS1&mt=1&rt=0
to make sure that you are not left behind.

----------------------

=====================================================================

You have been sent this Table of Contents Alert because you have opted in to receive it.
You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at:
http://links.ealert.nature.com/ctt?kn=27&m=34787080&r=MTc2MzAwNDQzNwS2&b=2&j=NzIwMjQ1NDcS1&mt=1&rt=0
(You will need to log in to be recognised as a nature.com registrant).

For further technical assistance, please contact our registration department:
registration@nature.com

For print subscription enquiries, please contact our subscription department:
subscriptions@nature.com

For other enquiries, please contact customer feedback department:
feedback@nature.com

Nature Publishing Group | 75 Varick Street, 9th Floor | New York | NY 10013-1917 | USA

Nature Publishing Group's worldwide offices:
London - Paris - Munich - New Delhi - Tokyo - Melbourne - San Diego - San Francisco - Washington - New York - Boston

=====================================================================

Oncogene - Table of Contents alert Volume 29 Issue 15

2010-04-15T02:34:00.001-07:00

ONCOGENE

April 2010 Volume 29 Number 15, pp 2161 - 2308

-----------------------------------------------------------------------
miRNA functional studies made easy!

Buy 3'UTRs delivered in luciferase reporter vectors for cell-based assays.
Measure miRNA function quickly and easily. Screen for miRNA function
with experimentally-validated target 3'UTRs for miR-21, miR-155, miR-122,
miR-124, and many more! Visit SwitchGear Genomics and explore our sets of
genome-wide, assay-ready promoter and 3'UTR reporters.
http://links.ealert.nature.com/ctt?kn=43&m=34786495&r=MTc2ODI0Mjc1MwS2&b=2&j=NzIwMjE1OTAS1&mt=1&rt=0

-----------------------------------------------------------------------
New to NPG: Cell Death & Disease
http://links.ealert.nature.com/ctt?kn=24&m=34786495&r=MTc2ODI0Mjc1MwS2&b=2&j=NzIwMjE1OTAS1&mt=1&rt=0

Online. Open access. Translational cell death.

Brought to you by the editorial team of Cell Death & Differentiation,
Cell Death & Disease is a peer-reviewed open acess online journal
that publishes full-length papers, reviews, and commentaries describing
original research in the field of translational cell death.

Sign up today for Cell Death & Disease's ToC-alert at
http://links.ealert.nature.com/ctt?kn=53&m=34786495&r=MTc2ODI0Mjc1MwS2&b=2&j=NzIwMjE1OTAS1&mt=1&rt=0.

----------------------
REVIEW
----------------------
Targeting of mRNAs by multiple miRNAs: the next step
M E Peter
Abstract: http://links.ealert.nature.com/ctt?kn=62&m=34786495&r=MTc2ODI0Mjc1MwS2&b=2&j=NzIwMjE1OTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=74&m=34786495&r=MTc2ODI0Mjc1MwS2&b=2&j=NzIwMjE1OTAS1&mt=1&rt=0

----------------------
ORIGINAL ARTICLES
----------------------
High sensitivity to carcinogens in the brain of a mouse model of
Alzheimer's disease
J Serrano, A P Fernandez, R Martinez-Murillo and A Martinez
Abstract: http://links.ealert.nature.com/ctt?kn=75&m=34786495&r=MTc2ODI0Mjc1MwS2&b=2&j=NzIwMjE1OTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=72&m=34786495&r=MTc2ODI0Mjc1MwS2&b=2&j=NzIwMjE1OTAS1&mt=1&rt=0

Flanking sequence specificity determines coding microsatellite
heteroduplex and mutation rates with defective DNA mismatch repair (MMR)
H Chung, C G Lopez, D J Young, J F Lai, J Holmstrom, D Ream-Robinson,
B L Cabrera and J M Carethers
Abstract: http://links.ealert.nature.com/ctt?kn=73&m=34786495&r=MTc2ODI0Mjc1MwS2&b=2&j=NzIwMjE1OTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=70&m=34786495&r=MTc2ODI0Mjc1MwS2&b=2&j=NzIwMjE1OTAS1&mt=1&rt=0

Processing of CD109 by furin and its role in the regulation of TGF-[beta]
signaling
S Hagiwara, Y Murakumo, S Mii, T Shigetomi, N Yamamoto, H Furue, M Ueda
and M Takahashi
Abstract: http://links.ealert.nature.com/ctt?kn=71&m=34786495&r=MTc2ODI0Mjc1MwS2&b=2&j=NzIwMjE1OTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=66&m=34786495&r=MTc2ODI0Mjc1MwS2&b=2&j=NzIwMjE1OTAS1&mt=1&rt=0

Opposing effects of hMOF and SIRT1 on H4K16 acetylation and the sensitivity
to the topoisomerase II inhibitor etoposide
N Hajji, K Wallenborg, P Vlachos, J Fullgrabe, O Hermanson and B Joseph
Abstract: http://links.ealert.nature.com/ctt?kn=67&m=34786495&r=MTc2ODI0Mjc1MwS2&b=2&j=NzIwMjE1OTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=76&m=34786495&r=MTc2ODI0Mjc1MwS2&b=2&j=NzIwMjE1OTAS1&mt=1&rt=0

Rac1 is required for oncolytic NDV replication in human cancer cells
and establishes a link between tumorigenesis and sensitivity to oncolytic
virus
J Puhlmann, F Puehler, D Mumberg, P Boukamp and R Beier
Abstract: http://links.ealert.nature.com/ctt?kn=23&m=34786495&r=MTc2ODI0Mjc1MwS2&b=2&j=NzIwMjE1OTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=25&m=34786495&r=MTc2ODI0Mjc1MwS2&b=2&j=NzIwMjE1OTAS1&mt=1&rt=0

Epigenetic regulation of the human p53 gene promoter by the CTCF transcription
factor in transformed cell lines
E Soto-Reyes and F Recillas-Targa
Abstract: http://links.ealert.nature.com/ctt?kn=26&m=34786495&r=MTc2ODI0Mjc1MwS2&b=2&j=NzIwMjE1OTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=27&m=34786495&r=MTc2ODI0Mjc1MwS2&b=2&j=NzIwMjE1OTAS1&mt=1&rt=0

Accelerated hepatocellular carcinoma development in mice expressing the
Pim-3 transgene selectively in the liver
Y Wu, Y Y Wang, Y Nakamoto, Y-Y Li, T Baba, S Kaneko, C Fujii and N Mukaida
Abstract: http://links.ealert.nature.com/ctt?kn=28&m=34786495&r=MTc2ODI0Mjc1MwS2&b=2&j=NzIwMjE1OTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=29&m=34786495&r=MTc2ODI0Mjc1MwS2&b=2&j=NzIwMjE1OTAS1&mt=1&rt=0

c-Abl regulates estrogen receptor [alpha] transcription activity through
its stabilization by phosphorylation
X He, Z Zheng, T Song, C Wei, H Ma, Q Ma, Y Zhang, Y Xu, W Shi, Q Ye
and H Zhong
Abstract: http://links.ealert.nature.com/ctt?kn=30&m=34786495&r=MTc2ODI0Mjc1MwS2&b=2&j=NzIwMjE1OTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=31&m=34786495&r=MTc2ODI0Mjc1MwS2&b=2&j=NzIwMjE1OTAS1&mt=1&rt=0

NUB1 promotes cytoplasmic localization of p53 through cooperation of the
NEDD8 and ubiquitin pathways
G Liu and D P Xirodimas
Abstract: http://links.ealert.nature.com/ctt?kn=33&m=34786495&r=MTc2ODI0Mjc1MwS2&b=2&j=NzIwMjE1OTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=35&m=34786495&r=MTc2ODI0Mjc1MwS2&b=2&j=NzIwMjE1OTAS1&mt=1&rt=0

Multiple microRNAs rescue from Ras-induced senescence by inhibiting
p21Waf1/Cip1
V Borgdorff, M E Lleonart, C L Bishop, D Fessart, A H Bergin, M G Overhoff
and D H Beach
Abstract: http://links.ealert.nature.com/ctt?kn=42&m=34786495&r=MTc2ODI0Mjc1MwS2&b=2&j=NzIwMjE1OTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=6&m=34786495&r=MTc2ODI0Mjc1MwS2&b=2&j=NzIwMjE1OTAS1&mt=1&rt=0

DNA breaks at fragile sites generate oncogenic RET/PTC rearrangements
in human thyroid cells
M Gandhi, L W Dillon, S Pramanik, Y E Nikiforov and Y-H Wang
Abstract: http://links.ealert.nature.com/ctt?kn=7&m=34786495&r=MTc2ODI0Mjc1MwS2&b=2&j=NzIwMjE1OTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=3&m=34786495&r=MTc2ODI0Mjc1MwS2&b=2&j=NzIwMjE1OTAS1&mt=1&rt=0

Wip1 phosphatase is associated with chromatin and dephosphorylates [gamma]H2AX
to promote checkpoint inhibition
L Macurek, A Lindqvist, O Voets, J Kool, H R Vos and R H Medema
Abstract: http://links.ealert.nature.com/ctt?kn=4&m=34786495&r=MTc2ODI0Mjc1MwS2&b=2&j=NzIwMjE1OTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=11&m=34786495&r=MTc2ODI0Mjc1MwS2&b=2&j=NzIwMjE1OTAS1&mt=1&rt=0

----------------------
SHORT COMMUNICATIONS
----------------------
NFAT3 transcription factor inhibits breast cancer cell motility by
targeting the Lipocalin 2 gene
M Fougere, B Gaudineau, J Barbier, F Guaddachi, J-P Feugeas, D Auboeuf
and S Jauliac
Abstract: http://links.ealert.nature.com/ctt?kn=12&m=34786495&r=MTc2ODI0Mjc1MwS2&b=2&j=NzIwMjE1OTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=8&m=34786495&r=MTc2ODI0Mjc1MwS2&b=2&j=NzIwMjE1OTAS1&mt=1&rt=0

Multiple microRNAs modulate p21Cip1/Waf1 expression by directly targeting
its 3[prime] untranslated region
S Wu, S Huang, J Ding, Y Zhao, L Liang, T Liu, R Zhan and X He
Abstract: http://links.ealert.nature.com/ctt?kn=10&m=34786495&r=MTc2ODI0Mjc1MwS2&b=2&j=NzIwMjE1OTAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=15&m=34786495&r=MTc2ODI0Mjc1MwS2&b=2&j=NzIwMjE1OTAS1&mt=1&rt=0

---------------------------------------------------------------------
Ensure your access

Recommend now at
http://links.ealert.nature.com/ctt?kn=77&m=34786495&r=MTc2ODI0Mjc1MwS2&b=2&j=NzIwMjE1OTAS1&mt=1&rt=0

=====================================================================

You have been sent this Table of Contents Alert because you have opted
in to receive it. You can change or discontinue your e-mail alerts at
any time, by modifying your preferences on your nature.com account at:
http://links.ealert.nature.com/ctt?kn=59&m=34786495&r=MTc2ODI0Mjc1MwS2&b=2&j=NzIwMjE1OTAS1&mt=1&rt=0
(You will need to log in to be recognised as a nature.com registrant).

For further technical assistance, please contact our registration
department:
registration@nature.com

For print subscription enquiries, please contact our subscription
department:
subscriptions@nature.com

For other enquiries, please contact customer feedback department:
feedback@nature.com

Nature Publishing Group | 75 Varick Street, 9th Floor | New York | NY 10013-1917 | USA

Nature Publishing Group's worldwide offices:
London - Paris - Munich - New Delhi - Tokyo - Melbourne - San Diego - San Francisco - Washington - New York - Boston

=====================================================================

Nature 15 April 2010 Volume 464 Number 7291 pp957-1094

2010-04-14T10:59:00.001-07:00

NATURE

15 April 2010 Volume 464 Number 7291, pp 957 - 1094

Visit Nature online to browse the journal.

Now available at http://links.ealert.nature.com/ctt?kn=216&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0

Please note that you need to be a subscriber to enjoy full text
access to Nature online. To purchase a subscription, please visit:
http://links.ealert.nature.com/ctt?kn=84&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0

Alternatively, to recommend a subscription to your library, please
visit
http://links.ealert.nature.com/ctt?kn=40&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0

=========================== ADVERTISEMENT ===========================
RIKEN RESEARCH http://links.ealert.nature.com/ctt?kn=156&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0
Bringing the best of RIKEN to YOU!
Come in and see what's going on!
RIKEN RESEARCH reports on the most exciting research from one of
Japan's largest research organizations, RIKEN, for free.
Unlocking the power of wood:
http://links.ealert.nature.com/ctt?kn=143&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0
The ABC of a stress response:
http://links.ealert.nature.com/ctt?kn=213&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0

Keep up to date by registering for RIKEN RESEARCH e-alerts!
=====================================================================

=========================== ADVERTISEMENT ===========================
Expression Analysis - THE FIRST Illumina CSPro Service Provider, in
the world, to be THE FIRST to receive certification on all Illumina
platforms - Sequencing, Infinium Genotyping, Goldengate Genotyping
and Direct Hyb Gene. Another example how we make it easier to access
powerful genetic technologies.
ExpressionAnalysis.com/

http://links.ealert.nature.com/ctt?kn=125&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0
=====================================================================

=========================== ADVERTISEMENT ===========================
Seed and early stage companies and academic investigators - apply
today

$3 million in funding available for research or commercial MS
development projects

Click here to learn more and participate in an information call April
23rd
http://links.ealert.nature.com/ctt?kn=85&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0

Fast ForwardSM - We can help you move your innovative ideas forward
- faster.
=====================================================================

=========================== ADVERTISEMENT ===========================
Nature Communications - Now Live!

To celebrate the launch, ALL articles are available to access FREE* at
http://links.ealert.nature.com/ctt?kn=218&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0

*Free access to subscribed-access manuscripts is available until
September 30th, 2010.
=====================================================================

=========================== ADVERTISEMENT ===========================
Science socially - Follow us on Twitter and Facebook

Follow Nature News on Twitter for as-it-happens access to science
news, comment, and opinion.
http://links.ealert.nature.com/ctt?kn=16&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0

Become a Nature.com Facebook fan, and every day we will let you know
about the latest science news, features, videos and podcasts,
applications, specials, offers and events from across nature.com.
We'll also alert you to job vacancies and news from Nature Publishing
Group, and ask your opinion on the issues of the day.
http://links.ealert.nature.com/ctt?kn=152&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0
=====================================================================

----------------------
EDITORIALS
----------------------
Testing time for gene patents p957
A surprising US court decision highlights the need to modernize
gene-patenting practices if patients are to benefit from advances in
genetic research.
doi:10.1038/464957a
http://links.ealert.nature.com/ctt?kn=88&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0

Winners take all pp957-958
Scientific competition is lacking in Japan, and efforts to increase
it are not always best focused.
doi:10.1038/464957b
http://links.ealert.nature.com/ctt?kn=96&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0

Welcome Nature Communications p958
doi:10.1038/464958a
http://links.ealert.nature.com/ctt?kn=94&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0

----------------------
RESEARCH HIGHLIGHTS
----------------------
Animal behaviour: Behind enemy lines p960
doi:10.1038/464960a
http://links.ealert.nature.com/ctt?kn=61&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0

Pathology: Bent out of shape p960
doi:10.1038/464960b
http://links.ealert.nature.com/ctt?kn=66&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0

Nanotechnology: Down the tube p960
doi:10.1038/464960c
http://links.ealert.nature.com/ctt?kn=72&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0

Planetary science: Venus vents p960
doi:10.1038/464960d
http://links.ealert.nature.com/ctt?kn=77&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0

Neuroscience: Stressing memory p960
doi:10.1038/464960e
http://links.ealert.nature.com/ctt?kn=122&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0

Physics: Monopoles on demand pp960-961
doi:10.1038/464960f
http://links.ealert.nature.com/ctt?kn=92&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0

Oceanography: Early bloomers p961
doi:10.1038/464961a
http://links.ealert.nature.com/ctt?kn=106&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0

Behavioural genetics: South bee-ch diet p961
doi:10.1038/464961b
http://links.ealert.nature.com/ctt?kn=98&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0

Seismology: On shaky ground p961
doi:10.1038/464961c
http://links.ealert.nature.com/ctt?kn=117&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0

Astrophysics: The odd couple p961
doi:10.1038/464961d
http://links.ealert.nature.com/ctt?kn=112&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0

----------------------
JOURNAL CLUB
----------------------
Journal club p961
Xing Xu
doi:10.1038/464961e
http://links.ealert.nature.com/ctt?kn=37&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0

----------------------
NEWS
----------------------
News briefing: 15 April 2010 pp962-963
The week in science.
doi:10.1038/464962a
http://links.ealert.nature.com/ctt?kn=244&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0

Lab-animal battle reaches truce p964
Biomedical scientists say revised European directive on animal
welfare averts feared disaster for research.
Alison Abbott
doi:10.1038/464964a
http://links.ealert.nature.com/ctt?kn=263&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0

US nuclear policy could boost basic research p965
National laboratories to see funding increases.
Jeff Tollefson
doi:10.1038/464965a
http://links.ealert.nature.com/ctt?kn=261&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0

Japan rolls out elite science funds pp966-967
FIRST scheme targets large grants to world-leading researchers.
David Cyranoski
doi:10.1038/464966a
http://links.ealert.nature.com/ctt?kn=259&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0

Stem-cell funding in sight p967
Most popular cell lines close to approval for US federal funding.
Meredith Wadman
doi:10.1038/464967a
http://links.ealert.nature.com/ctt?kn=264&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0

What it will take to feed the world p969
Nature talks to the chief executive of France's national agricultural
institute.
Declan Butler
doi:10.1038/464969a
http://links.ealert.nature.com/ctt?kn=296&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0

Pentagon turns to 'softer' sciences p970
US defence research to focus more on biology, cybersecurity and
social sciences to help win conflicts.
Sharon Weinberger
doi:10.1038/464970a
http://links.ealert.nature.com/ctt?kn=293&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0

Panel to take broad view of bioethics p971
President Obama appoints commission to advise on stem cells, clinical
trials and more.
Brendan Borrell
doi:10.1038/464971a
http://links.ealert.nature.com/ctt?kn=290&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0

----------------------
NEWS FEATURE
----------------------
Big science: The cancer genome challenge pp972-974
Databases could soon be flooded with genome sequences from 25,000
tumours. Heidi Ledford looks at the obstacles researchers face as
they search for meaning in the data.
Heidi Ledford
doi:10.1038/464972a
http://links.ealert.nature.com/ctt?kn=274&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0

----------------------
COLUMN
----------------------
Moment of reckoning p975
Tough choices lie ahead in UK research policy, and they need to
be debated openly in the general election campaign,
says Colin Macilwain.
doi:10.1038/464975a
http://links.ealert.nature.com/ctt?kn=280&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0

----------------------
CORRESPONDENCE
----------------------
Questioning how different societies respond to crises p977
Patricia A. McAnany and Norman Yoffee
doi:10.1038/464977a
http://links.ealert.nature.com/ctt?kn=33&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0

Students caught up in legal impasse at Mexican institute p977
Aaron Morelos Gomez, Eduardo Gracia Espino and Juan Carlos
Garcia Gallegos
doi:10.1038/464977b
http://links.ealert.nature.com/ctt?kn=35&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0

Weighing up the case for telescope site on La Palma p977
Francisco Sanchez
doi:10.1038/464977c
http://links.ealert.nature.com/ctt?kn=29&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0

----------------------
OPINION
----------------------
Let parents decide pp978-979
Twenty years on from the first pregnancies after preimplantation
genetic diagnosis, Alan Handyside argues that informed prospective
parents are largely good guides to the use of the thriving technology.
Alan Handyside
doi:10.1038/464978a
http://links.ealert.nature.com/ctt?kn=31&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0

----------------------
BOOKS AND ARTS
----------------------
Beyond the image of the tragic genius p980
Our stereotypical view of mathematicians shifted during the Romantic
era from worldly scholar to tortured soul, explains Jascha Hoffman.
Jascha Hoffman reviews Duel at Dawn: Heroes, Martyrs, and the Rise
of Modern Mathematics by Amir Alexander
doi:10.1038/464980a
http://links.ealert.nature.com/ctt?kn=52&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0

Calibrating the scales of suffering p981
Clive Wynne reviews Do Fish Feel Pain? by Victoria Braithwaite
doi:10.1038/464981a
http://links.ealert.nature.com/ctt?kn=50&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0

Books in brief p982
Joanne Baker
doi:10.1038/464982b
http://links.ealert.nature.com/ctt?kn=48&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0

Artificial reefs to buffer New York pp982-983
Josie Glausiusz reviews Rising Currents: Projects for New York's
Waterfront
doi:10.1038/464982a
http://links.ealert.nature.com/ctt?kn=46&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0

Q&A: John Sims on mathematical art p983
While pursuing his doctorate in dynamical systems, John Sims was
drawn to explore the connections between mathematics and art. Now
curating a year-long series of maths-art shows at the Bowery Poetry
Club in New York City, the conceptual artist explains the cultural
significance of maths.
Jascha Hoffman
doi:10.1038/464983a
http://links.ealert.nature.com/ctt?kn=44&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0

----------------------
NEWS AND VIEWS
----------------------
Complex networks: The fragility of interdependency pp984-985
A study of failures in interconnected networks highlights the
vulnerability of tightly coupled infrastructures and shows the need
to consider mutually dependent network properties in designing
resilient systems.
Alessandro Vespignani
doi:10.1038/464984a
http://links.ealert.nature.com/ctt?kn=8&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0

Genomics: Lessons in complexity from yeast pp985-986
A challenge in biology is to understand complex traits, which are
influenced by many genetic variants. Studies in yeast provide the
prospect of analysing such genetic variation in detail in other
organisms, including humans.
David B. Goldstein and Mohamed A. F. Noor
doi:10.1038/464985a
http://links.ealert.nature.com/ctt?kn=2&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0

50 & 100 years ago p986
doi:10.1038/464986a
http://links.ealert.nature.com/ctt?kn=6&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0

Single-molecule analysis: A ribosome in action pp987-988
The manufacture of proteins by ribosomes involves complex
interactions of diverse nucleic-acid and protein ligands.
Single-molecule studies allow us, for the first time, to follow the
synthesis of full-length proteins in real time.
Susanne Brakmann
doi:10.1038/464987a
http://links.ealert.nature.com/ctt?kn=23&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0

Information science: Guaranteed randomness pp988-989
You have received a device that is claimed to produce random numbers,
but you don't trust it. Can you check it without opening it? In some
cases, you can, thanks to the bizarre nature of quantum physics.
Valerio Scarani
doi:10.1038/464988a
http://links.ealert.nature.com/ctt?kn=25&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0

Cancer: Genomics of metastasis pp989-990
Cancer cells that invade other parts of the body do so by accumulating
genomic aberrations. Analysis of the genomic differences between
primary and metastatic tumours should aid the understanding of this
process.
Joe Gray
doi:10.1038/464989a
http://links.ealert.nature.com/ctt?kn=18&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0

Vision: Fisheye views p990
Tim Lincoln
doi:10.1038/464990a
http://links.ealert.nature.com/ctt?kn=311&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0

Behavioural ecology: Ways to raise tadpoles pp990-991
To reduce parental care, just add water -- that's the conclusion of
an intriguing investigation into the extent of the motherly and
fatherly devotion that different species of frog extend to their
offspring.
Hanna Kokko and Michael Jennions
doi:10.1038/464990b
http://links.ealert.nature.com/ctt?kn=307&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0

Obituary: Leena Peltonen-Palotie (1952-2010) p992
A visionary in medical genetics.
Gertjan van Ommen
doi:10.1038/464992a
http://links.ealert.nature.com/ctt?kn=318&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0

----------------------
PERSPECTIVES
----------------------
International network of cancer genome projects pp993-998
The International Cancer Genome Consortium
doi:10.1038/nature08987
Abstract: http://links.ealert.nature.com/ctt?kn=308&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=313&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0

----------------------
ARTICLES
----------------------
Genome remodelling in a basal-like breast cancer metastasis and
xenograft pp999-1005
Massively parallel DNA sequencing allows entire genomes to be
screened for genetic changes associated with tumour progression. Here,
the genomes of four DNA samples from a 44-year-old African-American
patient with basal-like breast cancer were analysed. The samples came
from peripheral blood, the primary tumour, a brain metastasis and a
xenograft derived from the primary tumour. The findings indicate that
cells with a distinct subset of the primary tumour mutation might be
selected during metastasis and xenografting.
Li Ding et al.
doi:10.1038/nature08989
Abstract: http://links.ealert.nature.com/ctt?kn=310&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=299&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0

Molecular basis of infrared detection by snakes pp1006-1011
Snakes are notoriously apt at generating 'thermal images' of
predators or prey. The underlying physiology has been unclear,
although in snakes such as pythons, vipers and boas, infrared signals
are initially received by the pit organ. Here it is shown that
pit-bearing snakes rely on heat detection by the ion channel TRPA1.
This extends the sensory repertoire of the TRPA1 family of proteins,
which detect chemical irritants in mammals and thermal variations in
insects.
Elena O. Gracheva et al.
doi:10.1038/nature08943
Abstract: http://links.ealert.nature.com/ctt?kn=304&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=281&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0

Real-time tRNA transit on single translating ribosomes at codon
resolution pp1012-1017
Single-molecule studies allow biological processes to be examined
one molecule at a time, as they occur. Here, zero-mode waveguides
have been used to concentrate reactions in zeptolitre-sized volumes,
making it possible to study real-time translocation by the ribosome.
The binding of transfer RNAs (tRNAs) to the ribosome could be
followed; the results show that tRNA release from the exit site is
uncoupled from tRNA binding to the aminoacyl-tRNA site.
Sotaro Uemura et al.
doi:10.1038/nature08925
Abstract: http://links.ealert.nature.com/ctt?kn=306&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=24&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0

----------------------
LETTERS
----------------------
An image of an exoplanet separated by two diffraction beamwidths
from a star pp1018-1020
Three exoplanets around the star HR 8799 have recently been discovered
by differential imaging with large telescopes. In such cases, bright
scattered starlight means that large angular offsets of the star are
required for high-contrast imaging of the planets. Imaging at small
angles requires a technique for reducing starlight and associated
noise while still transmitting light from the planet. Here such a
technique is described: all three HR 8799 planets have been detected
using a vector vortex coronagraph on a small-aperture system.
E. Serabyn, D. Mawet and R. Burruss
doi:10.1038/nature09007
Abstract: http://links.ealert.nature.com/ctt?kn=315&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=243&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0

Random numbers certified by Bell's theorem pp1021-1024
Here it is shown, both theoretically and experimentally, that
non-local correlations between entangled quantum particles can be
used for a new cryptographic application -- the generation of
certified private random numbers -- that is impossible to achieve
classically. The results have implications for future
device-independent quantum information experiments and for addressing
fundamental issues regarding the randomness of quantum theory.
S. Pironio et al.
doi:10.1038/nature09008
Abstract: http://links.ealert.nature.com/ctt?kn=317&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=17&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0

Catastrophic cascade of failures in interdependent networks pp1025-1028
Modern networks are rarely independent, instead being coupled together
with many others. Thus the failure of a small fraction of nodes in one
network may lead to the complete fragmentation of a system of several
interdependent networks. Here, a framework is developed for
understanding the robustness of interacting networks subject to such
'cascading' failures. Surprisingly, a broader degree distribution
increases the vulnerability of interdependent networks to random failure.
Sergey V. Buldyrev et al.
doi:10.1038/nature08932
Abstract: http://links.ealert.nature.com/ctt?kn=312&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=11&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0

Phosphate oxygen isotopic evidence for a temperate and biologically
active Archaean ocean pp1029-1032
It has been thought that ocean temperatures during the early
Palaeoarchaean era (around 3.5 billion years ago) were 55-85 [deg]C.
But a recent study indicated that the temperatures might be no higher
than 40 [deg]C. Here, studies are reported of the oxygen isotope
compositions of phosphates in sediments from the
3.2-3.5-billion-year-old Barberton Greenstone Belt in South Africa.
The findings indicate a well-developed phosphorus cycle and evolved
biological activity in an Archaean ocean with temperatures of 26-35
[deg]C.
Ruth E. Blake, Sae Jung Chang and Aivo Lepland
doi:10.1038/nature08952
Abstract: http://links.ealert.nature.com/ctt?kn=223&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=252&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0

Perigord black truffle genome uncovers evolutionary origins and
mechanisms of symbiosis pp1033-1038
The genome of the black truffle - one of the most popular truffles on
the market - has been sequenced. This is the first genome of a
symbiotic ascomycete to be analysed. Comparison with the genome of
another ectomycorrhizal symbiotic fungus indicates that a genetic
predisposition to symbiosis evolved differently in ascomycetes and
basidiomycetes. The study also offers insight into fungal sex and
fruiting.
Francis Martin et al.
doi:10.1038/nature08867
Abstract: http://links.ealert.nature.com/ctt?kn=224&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=101&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0

Dissection of genetically complex traits with extremely large pools
of yeast segregants pp1039-1042
Complex heritable traits -- such as human height and many human
diseases -- are caused by multiple genetic loci, each with small
effects. It is hard to identify such loci, however, because of a lack
of statistical power. Now, a method has been developed to overcome
this problem. The method has been applied to chemical resistance
traits and mitochondrial function in yeast, and has identified loci
for each of these phenotypes.
Ian M. Ehrenreich et al.
doi:10.1038/nature08923
Abstract: http://links.ealert.nature.com/ctt?kn=225&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=5&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0

APCDD1 is a novel Wnt inhibitor mutated in hereditary hypotrichosis
simplex pp1043-1047
Hereditary hypotrichosis simplex is a rare form of hereditary hair
loss in humans, where the hair follicle is miniaturized. Now, the
gene involved has been identified, using genetic linkage analysis in
three affected families. The gene, APCDD1, is expressed in human hair
follicles. It encodes a previously unknown membrane-bound glycoprotein
that inhibits signalling through the Wnt protein and functions
upstream of [beta]-catenin.
Yutaka Shimomura et al.
doi:10.1038/nature08875
Abstract: http://links.ealert.nature.com/ctt?kn=226&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=78&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0

Functional genomic screen for modulators of ciliogenesis and cilium
length pp1048-1051
Primary cilia are tiny hair-like structures expressed on the surface
of eukaryotic cells. They participate in a range of processes, such
as sensing the extracellular environment and regulating signalling
pathways during development. Here, a functional genomic screen is
presented that used RNA interference to identify human genes involved
in controlling ciliogenesis. Several positive and negative
ciliogenesis modulators with broad-ranging functions were found.
Joon Kim et al.
doi:10.1038/nature08895
Abstract: http://links.ealert.nature.com/ctt?kn=219&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=62&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0

Therapeutic antibody targeting of individual Notch receptors
pp1052-1057
The four receptors of the Notch family are transmembrane proteins
through which mammalian cells communicate to regulate cell fate and
growth. Aberrant signalling through each receptor has been linked to
disease, so the Notch pathway is a compelling drug target. But current
drugs cannot distinguish between the different Notch proteins. Here,
phage display technology has been used to generate highly specialized
antibodies, enabling the functions of Notch1 and Notch2 to be
discriminated in humans and mice.
Yan Wu et al.
doi:10.1038/nature08878
Abstract: http://links.ealert.nature.com/ctt?kn=220&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=73&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0

Chemoprevention of colorectal cancer by targeting APC-deficient cells
for apoptosis pp1058-1061
Cancer 'chemoprevention' uses substances to reverse, suppress or
prevent the initial phase of carcinogenesis or the progression of
neoplastic cells to cancer cells. Here it is shown that treatment
with TRAIL proteins and all-trans-retinyl acetate can cause the
death, in vitro and in vivo, of premalignant cells deficient in the
adenomatous polyposis coli gene. Normal cells are unaffected.
Selectively eliminating premalignant tumour cells in this way is thus
an effective method for chemoprevention.
Ling Zhang et al.
doi:10.1038/nature08871
Abstract: http://links.ealert.nature.com/ctt?kn=221&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=183&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0

Migrastatin analogues target fascin to block tumour metastasis pp1062-1066
Analogues of migrastatin -- a natural product secreted by Streptomyces
-- are potent inhibitors of tumour cell migration and metastasis.
Here, the underlying mechanism is elucidated: these migrastatin
analogues target and inhibit the activity of the actin-bundling
protein fascin. Hence proteins such as fascin might present new
molecular targets for cancer treatments.
Lin Chen et al.
doi:10.1038/nature08978
Abstract: http://links.ealert.nature.com/ctt?kn=222&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=173&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0

Evidence of RNAi in humans from systemically administered siRNA via
targeted nanoparticles pp1067-1070
It has previously been shown in mice and non-human primates that
systemically delivered short RNA molecules can inhibit gene
expression. Here it is shown that a short interfering RNA (siRNA) can
be systemically delivered, using nanoparticles, to a solid tumour in
humans. The siRNA mediates cleavage of its target mRNA, thereby also
reducing levels of the encoded protein. This proof-of-principle study
confirms the potential of this technology for treating human disease.
Mark E. Davis et al.
doi:10.1038/nature08956
Abstract: http://links.ealert.nature.com/ctt?kn=228&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=177&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0

Long non-coding RNA HOTAIR reprograms chromatin state to promote
cancer metastasis pp1071-1076
Large intervening non-coding RNAs (lincRNAs) are pervasively
transcribed in the genome. Here it is shown that lincRNAs in the HOX
genetic loci are dysregulated during breast cancer progression in
human cells, and that expression levels of the lincRNA called HOTAIR
can predict whether a tumour will metastasize. Moreover, enforced
expression of HOTAIR can lead to altered patterns of binding of the
PRC2 protein to the genome.
Rajnish A. Gupta et al.
doi:10.1038/nature08975
Abstract: http://links.ealert.nature.com/ctt?kn=229&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=200&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0

Fructose 1,6-bisphosphate aldolase/phosphatase may be an ancestral
gluconeogenic enzyme pp1077-1081
Thermophilic bacteria and archaea use carbon dioxide or carbon
monoxide as a starting material for making the organic substances
used in cellular molecules. A central enzyme in this pathway has now
been discovered, namely fructose 1,6-bisphosphate aldolase/phosphatase.
This enzyme might represent the ancestral gluconeogenic enzyme.
Rafael F. Say and Georg Fuchs
doi:10.1038/nature08884
Abstract: http://links.ealert.nature.com/ctt?kn=231&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=204&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0

CpG islands influence chromatin structure via the CpG-binding protein
Cfp1 pp1082-1086
Most human gene promoters are embedded within CpG islands that lack
DNA methylation and coincide with sites at which histone H3 lysine 4
is trimethylated (H3K4me3 sites). Here, a zinc-finger protein, Cfp1,
is found to be associated with non-methylated CpG islands and H3K4me3
sites throughout the genome in the mouse brain. A primary function of
non-methylated CpG islands might be to genetically determine the local
chromatin modification state by interaction with Cfp1 and perhaps
other CpG-binding proteins.
John P. Thomson et al.
doi:10.1038/nature08924
Abstract: http://links.ealert.nature.com/ctt?kn=242&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=150&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0

----------------------
NATUREJOBS
----------------------
Careers Q&A
Harmit Malik p1089
Evolutionary geneticist Harmit Malik of the Fred Hutchinson Cancer
Research Center in Seattle, Washington, has won the 2010 Vilcek Prize
for Creative Promise in Biomedical Science for his work on the
coevolution of humans and diseases.
Virginia Gewin
doi:10.1038/nj7291-1089a
http://links.ealert.nature.com/ctt?kn=129&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0

In Brief
US overseas applicants up p1089
Applications from China rise by nearly one-fifth.
doi:10.1038/nj7291-1089b
http://links.ealert.nature.com/ctt?kn=132&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0

In Brief
Science funding boost p1089
Programmes will support undergraduate and postgraduate students.
doi:10.1038/nj7291-1089c
http://links.ealert.nature.com/ctt?kn=130&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0

In Brief
Industry job cuts plunge p1089
Layoffs slow but companies are still not ready to begin hiring.
doi:10.1038/nj7291-1089d
http://links.ealert.nature.com/ctt?kn=140&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0

Careers and Recruitment
A systems approach p1090
Applying systems biology to cancer research has become a growth area
for computationally minded scientists. Kelly Rae Chi tallies the
possibilities.
Kelly Rae Chi
doi:10.1038/nj7291-1090a
http://links.ealert.nature.com/ctt?kn=137&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0

----------------------
FUTURES
----------------------
The frozen hive of her mind p1094
A familiar face.
Deborah Walker
doi:10.1038/4641094a
http://links.ealert.nature.com/ctt?kn=147&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0

----------------------
Advance Online Publication
----------------------
14 April 2010
Control of cortical GABA circuitry development by Nrg1 and ErbB4
signalling
Pietro Fazzari et al.
doi:10.1038/nature08928
Abstract: http://links.ealert.nature.com/ctt?kn=148&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=148&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0

Innate lymphoid cells drive interleukin-23-dependent innate intestinal
pathology
Sofia Buonocore et al.
doi:10.1038/nature08949
Abstract: http://links.ealert.nature.com/ctt?kn=168&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=168&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0

Pronuclear transfer in human embryos to prevent transmission of
mitochondrial DNA disease
Lyndsey Craven et al.
doi:10.1038/nature08958
Abstract: http://links.ealert.nature.com/ctt?kn=165&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=165&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0

Olfactory pattern classification by discrete neuronal network states
Jorn Niessing and Rainer W. Friedrich
doi:10.1038/nature08961
Abstract: http://links.ealert.nature.com/ctt?kn=161&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=161&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0

Widespread transcription at neuronal activity-regulated enhancers
Tae-Kyung Kim et al.
doi:10.1038/nature09033
Abstract: http://links.ealert.nature.com/ctt?kn=158&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=158&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0

11 April 2010
I[kgr]B[zgr] regulates TH17 development by cooperating with ROR
nuclear receptors
Kazuo Okamoto et al.
doi:10.1038/nature08922
Abstract: http://links.ealert.nature.com/ctt?kn=270&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=270&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0

Ku is a 5[prime]-dRP/AP lyase that excises nucleotide damage near
broken ends
Steven A. Roberts et al.
doi:10.1038/nature08926
Abstract: http://links.ealert.nature.com/ctt?kn=279&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=279&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0

Tracking G-protein-coupled receptor activation using genetically
encoded infrared probes
Shixin Ye et al.
doi:10.1038/nature08948
Abstract: http://links.ealert.nature.com/ctt?kn=286&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=286&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0

Control of mammary stem cell function by steroid hormone signalling
Marie-Liesse Asselin-Labat et al.
doi:10.1038/nature09027
Abstract: http://links.ealert.nature.com/ctt?kn=298&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=298&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0

=========================== ADVERTISEMENT ===========================
FREE ARTICLES FROM SciBX

Infectious disease: Mosaic HIV vaccines
Full text:
http://links.ealert.nature.com/ctt?kn=155&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0
PDF:
http://links.ealert.nature.com/ctt?kn=180&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0

Endocrine disease: Substituting leptin for insulin in type 1 diabetes
Full text:
http://links.ealert.nature.com/ctt?kn=179&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0
PDF:
http://links.ealert.nature.com/ctt?kn=184&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0

Infectious diseases: Pseudomonas-specific, protegrin-I epitope mimetic
antibacterials
Full text:
http://links.ealert.nature.com/ctt?kn=182&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0
PDF:
http://links.ealert.nature.com/ctt?kn=181&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0

ACCESS TO MORE THAN 40 FREE ARTICLES from the SciBX Cover Story Archive
http://links.ealert.nature.com/ctt?kn=15&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0
=====================================================================

You have been sent this Table of Contents Alert because you have opted in to
receive it. You can change or discontinue your e-mail alerts at any time,
by modifying your preferences on your nature.com account at:
http://links.ealert.nature.com/ctt?kn=39&m=34784331&r=MjA1NTkxMDA2MAS2&b=2&j=NzE5OTE1NjMS1&mt=1&rt=0
(You will need to log in to be recognised as a nature.com registrant).

For further technical assistance, please contact our registration department:
registration@nature.com

For print subscription enquiries, please contact our subscription department:
subscriptions@nature.com

For other enquiries, please contact our customer feedback department:
feedback@nature.com

Nature Publishing Group | 75 Varick Street, 9th Floor | New York |
NY 10013-1917 | USA

Nature Publishing Group's worldwide offices:
London - Paris - Munich - New Delhi - Tokyo - Melbourne -
San Diego - San Francisco - Washington - New York - Boston

=====================================================================

British Journal of Cancer - Table of Contents alert Volume 102 Issue S1

2010-04-14T09:43:00.001-07:00

Prevention and Treatment of Cancer-Associated Thrombosis:

A Report on a Roundtable Meeting

Edited by: AK Kakkar and R Coleman

BRITISH JOURNAL OF CANCER

Volume 102 Number S1
Published online 13 April 2010 (S1 - S29)

---------------------------------------------------------------------

British Journal of Cancer publishes high quality original papers and
reviews that make a significant contribution to increasing understanding
of the causes of cancer and to improving the treatment and survival
of patients.

Visit the journal online at http://links.ealert.nature.com/ctt?kn=25&m=34784164&r=MTc2MDAwMTgxNgS2&b=2&j=NzE5ODk0ODMS1&mt=1&rt=0 to view the latest
research and access selected articles FREE of charge.

---------------------------------------------------------------------

----------------------
INTRODUCTION
----------------------
Cancer-associated thrombosis
A K Kakkar
http://links.ealert.nature.com/ctt?kn=33&m=34784164&r=MTc2MDAwMTgxNgS2&b=2&j=NzE5ODk0ODMS1&mt=1&rt=0

----------------------
PAPERS
----------------------
Epidemiology and pathophysiology of cancer-associated thrombosis
S Noble and J Pasi
Abstract: http://links.ealert.nature.com/ctt?kn=37&m=34784164&r=MTc2MDAwMTgxNgS2&b=2&j=NzE5ODk0ODMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=35&m=34784164&r=MTc2MDAwMTgxNgS2&b=2&j=NzE5ODk0ODMS1&mt=1&rt=0

Primary prevention of venous thromboembolism in medical and surgical
oncology patients
A Stanley and A Young
Abstract: http://links.ealert.nature.com/ctt?kn=40&m=34784164&r=MTc2MDAwMTgxNgS2&b=2&j=NzE5ODk0ODMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=39&m=34784164&r=MTc2MDAwMTgxNgS2&b=2&j=NzE5ODk0ODMS1&mt=1&rt=0

Treatment and secondary prevention of venous thromboembolism in cancer
R Coleman and P MacCallum
Abstract: http://links.ealert.nature.com/ctt?kn=43&m=34784164&r=MTc2MDAwMTgxNgS2&b=2&j=NzE5ODk0ODMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=41&m=34784164&r=MTc2MDAwMTgxNgS2&b=2&j=NzE5ODk0ODMS1&mt=1&rt=0

Antithrombotic therapy and survival in patients with malignant disease
A K Kakkar and F Macbeth
Abstract: http://links.ealert.nature.com/ctt?kn=45&m=34784164&r=MTc2MDAwMTgxNgS2&b=2&j=NzE5ODk0ODMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=44&m=34784164&r=MTc2MDAwMTgxNgS2&b=2&j=NzE5ODk0ODMS1&mt=1&rt=0

---------------------------------------------------------------------

Ensure your access to British Journal of Cancer

Recommend now at http://links.ealert.nature.com/ctt?kn=23&m=34784164&r=MTc2MDAwMTgxNgS2&b=2&j=NzE5ODk0ODMS1&mt=1&rt=0.

---------------------------------------------------------------------
=====================================================================

You have been sent this Table of Contents Alert because you have opted
in to receive it.
You can change or discontinue your e-mail alerts at any time, by modifying
your preferences on your nature.com account at:
http://links.ealert.nature.com/ctt?kn=21&m=34784164&r=MTc2MDAwMTgxNgS2&b=2&j=NzE5ODk0ODMS1&mt=1&rt=0
(You will need to log in to be recognised as a nature.com registrant).

For further technical assistance, please contact our registration department:
registration@nature.com

For print subscription enquiries, please contact our subscription department:
subscriptions@nature.com

For other enquiries, please contact customer feedback department:
feedback@nature.com

Nature Publishing Group | 75 Varick Street, 9th Floor | New York | NY 10013-1917 | USA

Nature Publishing Group's worldwide offices:
London - Paris - Munich - New Delhi - Tokyo - Melbourne - San Diego - San Francisco - Washington - New York - Boston

=====================================================================

Leukemia - Table of Contents alert Volume 24 Issue 4

2010-04-14T09:40:00.001-07:00

LEUKEMIA

April 2010 Volume 24 Number 4, pp 671 - 908

=====================================================================

Announcing an open access option in Leukemia.
http://links.ealert.nature.com/ctt?kn=37&m=34784146&r=MTc2MzIyNTA1NQS2&b=2&j=NzE5ODkyODkS1&mt=1&rt=0

An open access option is now available to all authors of original
research papers that are accepted for publication in Leukemia.
Open articles will be freely accessible to all readers immediately on publication.

Learn more about Open by visiting http://links.ealert.nature.com/ctt?kn=102&m=34784146&r=MTc2MzIyNTA1NQS2&b=2&j=NzE5ODkyODkS1&mt=1&rt=0.

=====================================================================

----------------------
REVIEWS
----------------------
Aurora kinase inhibitors: novel small molecules with promising
activity in acute myeloid and Philadelphia-positive leukemias
A S Moore, J Blagg, S Linardopoulos and A D J Pearson
Abstract: http://links.ealert.nature.com/ctt?kn=154&m=34784146&r=MTc2MzIyNTA1NQS2&b=2&j=NzE5ODkyODkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=6&m=34784146&r=MTc2MzIyNTA1NQS2&b=2&j=NzE5ODkyODkS1&mt=1&rt=0

[gamma]H2AX: a sensitive molecular marker of DNA damage and repair
L-J Mah, A El-Osta and T C Karagiannis
Abstract: http://links.ealert.nature.com/ctt?kn=8&m=34784146&r=MTc2MzIyNTA1NQS2&b=2&j=NzE5ODkyODkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=10&m=34784146&r=MTc2MzIyNTA1NQS2&b=2&j=NzE5ODkyODkS1&mt=1&rt=0

----------------------
ORIGINAL ARTICLES
----------------------
Erucylphosphohomocholine, the first intravenously applicable
alkylphosphocholine, is cytotoxic to acute myelogenous leukemia
cells through JNK- and PP2A-dependent mechanisms
A M Martelli, V Papa, P L Tazzari, F Ricci, C Evangelisti, F Chiarini,
C Grimaldi, A Cappellini, G Martinelli, E Ottaviani, P Pagliaro,
S Horn, J Basecke, L H Lindner, H Eibl and J A McCubrey
Abstract: http://links.ealert.nature.com/ctt?kn=12&m=34784146&r=MTc2MzIyNTA1NQS2&b=2&j=NzE5ODkyODkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=1&m=34784146&r=MTc2MzIyNTA1NQS2&b=2&j=NzE5ODkyODkS1&mt=1&rt=0

Phase I study of the heat shock protein 90 inhibitor alvespimycin
(KOS-1022, 17-DMAG) administered intravenously twice weekly
to patients with acute myeloid leukemia
J E Lancet, I Gojo, M Burton, M Quinn, S M Tighe, K Kersey,
Z Zhong, M X Albitar, K Bhalla, A L Hannah and M R Baer
Abstract: http://links.ealert.nature.com/ctt?kn=2&m=34784146&r=MTc2MzIyNTA1NQS2&b=2&j=NzE5ODkyODkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=3&m=34784146&r=MTc2MzIyNTA1NQS2&b=2&j=NzE5ODkyODkS1&mt=1&rt=0

Monitoring of adenovirus load in stool by real-time PCR permits
early detection of impending invasive infection in patients after
allogeneic stem cell transplantation
T Lion, K Kosulin, C Landlinger, M Rauch, S Preuner, D Jugovic,
U Potschger, A Lawitschka, C Peters, G Fritsch and S Matthes-Martin
Abstract: http://links.ealert.nature.com/ctt?kn=4&m=34784146&r=MTc2MzIyNTA1NQS2&b=2&j=NzE5ODkyODkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=155&m=34784146&r=MTc2MzIyNTA1NQS2&b=2&j=NzE5ODkyODkS1&mt=1&rt=0

The degree of myelosuppression during maintenance therapy of
adolescents with B-lineage intermediate risk acute lymphoblastic
leukemia predicts risk of relapse
K Schmiegelow, M Heyman, G Gustafsson, B Lausen, F Wesenberg,
J Kristinsson, K Vettenranta, H Schroeder, E Forestier and S Rosthoej
on behalf of the Nordic Society of Paediatric Haematology
and Oncology (NOPHO)
Abstract: http://links.ealert.nature.com/ctt?kn=146&m=34784146&r=MTc2MzIyNTA1NQS2&b=2&j=NzE5ODkyODkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=147&m=34784146&r=MTc2MzIyNTA1NQS2&b=2&j=NzE5ODkyODkS1&mt=1&rt=0

FES kinases are required for oncogenic FLT3 signaling
E Voisset, S Lopez, A Chaix, C Georges, K Hanssens, T Prebet,
P Dubreuil and P De Sepulveda
Abstract: http://links.ealert.nature.com/ctt?kn=144&m=34784146&r=MTc2MzIyNTA1NQS2&b=2&j=NzE5ODkyODkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=145&m=34784146&r=MTc2MzIyNTA1NQS2&b=2&j=NzE5ODkyODkS1&mt=1&rt=0

Targeting PKC[delta]-mediated topoisomerase II[beta] overexpression
subverts the differentiation block in a retinoic acid-resistant APL
cell line
S McNamara, J N Nichol, H Wang and W H Miller
Abstract: http://links.ealert.nature.com/ctt?kn=150&m=34784146&r=MTc2MzIyNTA1NQS2&b=2&j=NzE5ODkyODkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=151&m=34784146&r=MTc2MzIyNTA1NQS2&b=2&j=NzE5ODkyODkS1&mt=1&rt=0

Trisomy 11 in myelodysplastic syndromes defines a unique group
of disease with aggressive clinicopathologic features
S A Wang, K Jabbar, G Lu, S S Chen, N Galili, F Vega, D Jones,
A Raza, H Kantarjian, G Garcia-Manero, T J McDonnell and L J Medeiros
Abstract: http://links.ealert.nature.com/ctt?kn=148&m=34784146&r=MTc2MzIyNTA1NQS2&b=2&j=NzE5ODkyODkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=149&m=34784146&r=MTc2MzIyNTA1NQS2&b=2&j=NzE5ODkyODkS1&mt=1&rt=0

Lenalidomide induces cell death in an MDS-derived cell line with
deletion of chromosome 5q by inhibition of cytokinesis
A Matsuoka, A Tochigi, M Kishimoto, T Nakahara, T Kondo, T Tsujioka,
T Tasaka, Y Tohyama and K Tohyama
Abstract: http://links.ealert.nature.com/ctt?kn=132&m=34784146&r=MTc2MzIyNTA1NQS2&b=2&j=NzE5ODkyODkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=130&m=34784146&r=MTc2MzIyNTA1NQS2&b=2&j=NzE5ODkyODkS1&mt=1&rt=0

Deregulated gene expression pathways in myelodysplastic syndrome
hematopoietic stem cells
A Pellagatti, M Cazzola, A Giagounidis, J Perry, L Malcovati,
M G Della Porta, M Jadersten, S Killick, A Verma, C J Norbury,
E Hellstrom-Lindberg, J S Wainscoat and J Boultwood
Abstract: http://links.ealert.nature.com/ctt?kn=117&m=34784146&r=MTc2MzIyNTA1NQS2&b=2&j=NzE5ODkyODkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=124&m=34784146&r=MTc2MzIyNTA1NQS2&b=2&j=NzE5ODkyODkS1&mt=1&rt=0

Chronic Myeloid Leukemia CD34+ cells have reduced uptake of
imatinib due to low OCT-1 Activity
J R Engler, A Frede, V A Saunders, A C W Zannettino, T P Hughes
and D L White
Abstract: http://links.ealert.nature.com/ctt?kn=125&m=34784146&r=MTc2MzIyNTA1NQS2&b=2&j=NzE5ODkyODkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=126&m=34784146&r=MTc2MzIyNTA1NQS2&b=2&j=NzE5ODkyODkS1&mt=1&rt=0

Blocking cytokine signaling along with intense Bcr-Abl kinase
inhibition induces apoptosis in primary CML progenitors
D K Hiwase, D L White, J A Powell, V A Saunders, S A Zrim, A K Frede,
M A Guthridge, A F Lopez, R J D'Andrea, L B To, J V Melo, S Kumar
and T P Hughes
Abstract: http://links.ealert.nature.com/ctt?kn=127&m=34784146&r=MTc2MzIyNTA1NQS2&b=2&j=NzE5ODkyODkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=119&m=34784146&r=MTc2MzIyNTA1NQS2&b=2&j=NzE5ODkyODkS1&mt=1&rt=0

Role of BCR-ABL-Y177-mediated p27kip1 phosphorylation and cytoplasmic
localization in enhanced proliferation of chronic myeloid leukemia
progenitors
S Chu, T McDonald and R Bhatia
Abstract: http://links.ealert.nature.com/ctt?kn=120&m=34784146&r=MTc2MzIyNTA1NQS2&b=2&j=NzE5ODkyODkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=121&m=34784146&r=MTc2MzIyNTA1NQS2&b=2&j=NzE5ODkyODkS1&mt=1&rt=0

Serum metabolome analysis by 1H-NMR reveals differences between
chronic lymphocytic leukaemia molecular subgroups
D A MacIntyre, B Jimenez, E Jantus Lewintre, C Reinoso Martin,
H Schafer, C Garcia Ballesteros, J Ramon Mayans, M Spraul,
J Garcia-Conde and A Pineda-Lucena
Abstract: http://links.ealert.nature.com/ctt?kn=123&m=34784146&r=MTc2MzIyNTA1NQS2&b=2&j=NzE5ODkyODkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=105&m=34784146&r=MTc2MzIyNTA1NQS2&b=2&j=NzE5ODkyODkS1&mt=1&rt=0

Peptide vaccination elicits leukemia-associated antigen-specific
cytotoxic CD8+ T-cell responses in patients with chronic lymphocytic
leukemia
K Giannopoulos, A Dmoszynska, M Kowal, J Rolinski, E Gostick,
D A Price, J Greiner, M Rojewski, S Stilgenbauer, H Dohner
and M Schmitt
Abstract: http://links.ealert.nature.com/ctt?kn=89&m=34784146&r=MTc2MzIyNTA1NQS2&b=2&j=NzE5ODkyODkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=92&m=34784146&r=MTc2MzIyNTA1NQS2&b=2&j=NzE5ODkyODkS1&mt=1&rt=0

NF-[kappa]B activation mediates resistance to IFN[beta] in
MLL-rearranged acute lymphoblastic leukemia
L Tracey, C J Streck, Z Du, R F Williams, L M Pfeffer, A C Nathwani
and A M Davidoff
Abstract: http://links.ealert.nature.com/ctt?kn=103&m=34784146&r=MTc2MzIyNTA1NQS2&b=2&j=NzE5ODkyODkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=104&m=34784146&r=MTc2MzIyNTA1NQS2&b=2&j=NzE5ODkyODkS1&mt=1&rt=0

Development of resistance to dasatinib in Bcr/Abl-positive acute
lymphoblastic leukemia
F Fei, S Stoddart, M Muschen, Y-m Kim, J Groffen and N Heisterkamp
Abstract: http://links.ealert.nature.com/ctt?kn=100&m=34784146&r=MTc2MzIyNTA1NQS2&b=2&j=NzE5ODkyODkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=101&m=34784146&r=MTc2MzIyNTA1NQS2&b=2&j=NzE5ODkyODkS1&mt=1&rt=0

SHIP-1 inhibits CD95/APO-1/Fas-induced apoptosis in primary T
lymphocytes and T leukemic cells by promoting CD95 glycosylation
independently of its phosphatase activity
E Charlier, C Conde, J Zhang, L Deneubourg, E Di Valentin, S Rahmouni,
A Chariot, P Agostinis, P-C Pang, S M Haslam, A Dell, J Penninger,
C Erneux, J Piette and G Gloire
Abstract: http://links.ealert.nature.com/ctt?kn=98&m=34784146&r=MTc2MzIyNTA1NQS2&b=2&j=NzE5ODkyODkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=99&m=34784146&r=MTc2MzIyNTA1NQS2&b=2&j=NzE5ODkyODkS1&mt=1&rt=0

Correlation between array-comparative genomic hybridization-defined
genomic gains and losses and survival: identification of 1p31-32
deletion as a prognostic factor in myeloma
W J Chng, M A Gertz, T-H Chung, S Van Wier, J J Keats, A Baker,
P L Bergsagel, J Carpten and R Fonseca
Abstract: http://links.ealert.nature.com/ctt?kn=96&m=34784146&r=MTc2MzIyNTA1NQS2&b=2&j=NzE5ODkyODkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=97&m=34784146&r=MTc2MzIyNTA1NQS2&b=2&j=NzE5ODkyODkS1&mt=1&rt=0

Galectin-9 exhibits anti-myeloma activity through JNK and p38 MAP
kinase pathways
T Kobayashi, J Kuroda, E Ashihara, S Oomizu, Y Terui, A Taniyama,
S Adachi, T Takagi, M Yamamoto, N Sasaki, S Horiike, K Hatake,
A Yamauchi, M Hirashima and M Taniwaki
Abstract: http://links.ealert.nature.com/ctt?kn=80&m=34784146&r=MTc2MzIyNTA1NQS2&b=2&j=NzE5ODkyODkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=86&m=34784146&r=MTc2MzIyNTA1NQS2&b=2&j=NzE5ODkyODkS1&mt=1&rt=0

----------------------
LETTERS TO THE EDITOR
----------------------
Nucleoside analog ARC targets Mcl-1 to induce apoptosis in leukemia
cells
U G Bhat and A L Gartel
http://links.ealert.nature.com/ctt?kn=64&m=34784146&r=MTc2MzIyNTA1NQS2&b=2&j=NzE5ODkyODkS1&mt=1&rt=0

Nilotinib does not significantly reduce imatinib OCT-1 activity in
either cell lines or primary CML cells
L Eadie, T P Hughes and D L White
http://links.ealert.nature.com/ctt?kn=69&m=34784146&r=MTc2MzIyNTA1NQS2&b=2&j=NzE5ODkyODkS1&mt=1&rt=0

The NDE1 gene is disrupted by the inv(16) in 90% of cases with
CBFB-MYH11-positive acute myeloid leukemia
B A Van der Reijden, M Massop, A Simons, T de Witte, M Breuning
and J H Jansen
http://links.ealert.nature.com/ctt?kn=73&m=34784146&r=MTc2MzIyNTA1NQS2&b=2&j=NzE5ODkyODkS1&mt=1&rt=0

MPL mutation effect on JAK2 46/1 haplotype frequency in
JAK2V617F-negative myeloproliferative neoplasms
M M Patnaik, T L Lasho, C M Finke, N Gangat, D Caramazza, S Siragusa,
C A Hanson, A Pardanani and A Tefferi
http://links.ealert.nature.com/ctt?kn=76&m=34784146&r=MTc2MzIyNTA1NQS2&b=2&j=NzE5ODkyODkS1&mt=1&rt=0

NHR4 domain mutations of ETO are probably very infrequent in AML1-ETO
positive myeloid leukemia cells
B Hackanson, M Abdelkarim, J H Jansen and M Lubbert
http://links.ealert.nature.com/ctt?kn=52&m=34784146&r=MTc2MzIyNTA1NQS2&b=2&j=NzE5ODkyODkS1&mt=1&rt=0

Identification of activated Tnk1 kinase in Hodgkin's lymphoma
T-L Gu, J Cherry, M Tucker, J Wu, C Reeves and R D Polakiewicz
http://links.ealert.nature.com/ctt?kn=49&m=34784146&r=MTc2MzIyNTA1NQS2&b=2&j=NzE5ODkyODkS1&mt=1&rt=0

Specific induction of CD33 expression by E2A-HLF: the first evidence
for aberrant myeloid antigen expression in ALL by a fusion
transcription factor
K Akahane, T Inukai, T Inaba, H Kurosawa, A T Look, N Kiyokawa,
J Fujimoto, H Goto, M Endo, X Zhang, K Hirose, I Kuroda, H Honna,
K Kagami, K Goi, S Nakazawa and K Sugita
http://links.ealert.nature.com/ctt?kn=41&m=34784146&r=MTc2MzIyNTA1NQS2&b=2&j=NzE5ODkyODkS1&mt=1&rt=0

ON012380, a putative BCR-ABL kinase inhibitor with a unique mechanism
of action in imatinib-resistant cells
J Wu, F Meng, Y Ying, Z Peng, L Daniels, W G Bornmann,
A Quintas-Cardama, D Roulston, M Talpaz, L F Peterson and N J Donato
http://links.ealert.nature.com/ctt?kn=39&m=34784146&r=MTc2MzIyNTA1NQS2&b=2&j=NzE5ODkyODkS1&mt=1&rt=0

Proliferation centers in chronic lymphocytic leukemia: the niche where
NF-[kappa]B activation takes place
B Herreros, S M Rodriguez-Pinilla, R Pajares, M A Martinez-Gonzalez,
R Ramos, I Munoz, S Montes-Moreno, M Lozano, L Sanchez-Verde,
G Roncador, M Sanchez-Beato, R D de Otazu, M Perez-Guillermo,
M J Mestre, C Bellas and M A Piris
http://links.ealert.nature.com/ctt?kn=43&m=34784146&r=MTc2MzIyNTA1NQS2&b=2&j=NzE5ODkyODkS1&mt=1&rt=0

Variant IRF4/MUM1 associates with CD38 status and treatment-free
survival in chronic lymphocytic leukaemia
J M Allan, N J Sunter, J R Bailey, A R Pettitt, R J Harris, C Pepper,
C Fegan, A G Hall, L Deignan, C M Bacon, J C Pointon, R S Houlston,
P Broderick, T Mainou-Fowler, G H Jackson, G Summerfield, P A Evans,
J C Strefford, A Parker, D Oscier, G Pratt and D J Allsup
http://links.ealert.nature.com/ctt?kn=31&m=34784146&r=MTc2MzIyNTA1NQS2&b=2&j=NzE5ODkyODkS1&mt=1&rt=0

Chronic lymphoproliferative disorder of natural killer cells: a
distinct entity with subtypes correlating with normal natural killer
cell subsets
W G Morice, D Jevremovic, H Olteanu, A Roden, G Nowakowski, S Kroft,
C A Hanson and P J Kurtin
http://links.ealert.nature.com/ctt?kn=34&m=34784146&r=MTc2MzIyNTA1NQS2&b=2&j=NzE5ODkyODkS1&mt=1&rt=0

Biclonal origin prevails in concomitant chronic lymphocytic leukemia
and multiple myeloma
M Pantic, P Schroettner, D Pfeifer, J Rawluk, U Denz, A Schmitt-Graff,
H Veelken, R Wasch and M Engelhardt
http://links.ealert.nature.com/ctt?kn=27&m=34784146&r=MTc2MzIyNTA1NQS2&b=2&j=NzE5ODkyODkS1&mt=1&rt=0

The use of low-dose alemtuzumab in pretreated B-cell chronic
lymphocytic leukemia
M Tarnani, G D'Arena, D G Efremov, S Marietti, Sica S, G Leone
and L Laurenti
http://links.ealert.nature.com/ctt?kn=29&m=34784146&r=MTc2MzIyNTA1NQS2&b=2&j=NzE5ODkyODkS1&mt=1&rt=0

A novel exon in AML1-ETO negatively influences the clonogenic
potential of the t(8;21) in acute myeloid leukemia
D Mannari, D Gascoyne, J Dunne, T Chaplin and B Young
http://links.ealert.nature.com/ctt?kn=25&m=34784146&r=MTc2MzIyNTA1NQS2&b=2&j=NzE5ODkyODkS1&mt=1&rt=0

ARID5B SNP rs10821936 is associated with risk of childhood acute
lymphoblastic leukemia in blacks and contributes to racial differences
in leukemia incidence
W Yang, L R Trevino, J J Yang, P Scheet, C-H Pui, W E Evans
and M V Relling
http://links.ealert.nature.com/ctt?kn=18&m=34784146&r=MTc2MzIyNTA1NQS2&b=2&j=NzE5ODkyODkS1&mt=1&rt=0

Lck is a key target of imatinib and dasatinib in T-cell activation
K C Lee, I Ouwehand, A L Giannini, N S Thomas, N J Dibb and
M J Bijlmakers
http://links.ealert.nature.com/ctt?kn=16&m=34784146&r=MTc2MzIyNTA1NQS2&b=2&j=NzE5ODkyODkS1&mt=1&rt=0

Leukocytosis is associated with poor survival but not with increased
risk of thrombosis in essential thrombocythemia: a population-based
study of 311 patients
F Girodon, F Dutrillaux, J Broseus, M Mounier, V Goussot,
P Bardonnaud, M L Chretien and M Maynadie
http://links.ealert.nature.com/ctt?kn=13&m=34784146&r=MTc2MzIyNTA1NQS2&b=2&j=NzE5ODkyODkS1&mt=1&rt=0

Bimodal distribution of genomic MLL breakpoints in infant acute
lymphoblastic leukemia treatment
R Jung, U Jacobs, M Krumbholz, T Langer, T Keller, P De Lorenzo,
M G Valsecchi, V H J van der Velden, A Moericke, M Stanulla,
A Teigler-Schlegel, E R Panzer-Gruemayer, J J M van Dongen,
M Schrappe, M L den Boer, R Pieters, W Rascher and M Metzler
http://links.ealert.nature.com/ctt?kn=9&m=34784146&r=MTc2MzIyNTA1NQS2&b=2&j=NzE5ODkyODkS1&mt=1&rt=0

----------------------
CORRIGENDUM
----------------------
VEGF receptors on chronic lymphocytic leukemia (CLL) B cells interact
with STAT 1 and 3: implication for apoptosis resistance
Y K Lee, T D Shanafelt, N D Bone, A K Strege, D F Jelinek and N E Kay
http://links.ealert.nature.com/ctt?kn=5&m=34784146&r=MTc2MzIyNTA1NQS2&b=2&j=NzE5ODkyODkS1&mt=1&rt=0

=====================================================================

Looking for novel kinase inhibitors?

Selleck Chemicals provides novel kinase inhibitors for signal
transduction, oncology or other preclinical research. We have
inhibitors of PARP, EGFR, CDK, BCL-2,IGF-1R, HDAC, Aurora,
Mek, PI3K/Akt ,mTOR, c-Met, VEGFR, Src-brc-Abl, Hedgedog,
Proteasome and other 30 targets. visit : http://links.ealert.nature.com/ctt?kn=84&m=34784146&r=MTc2MzIyNTA1NQS2&b=2&j=NzE5ODkyODkS1&mt=1&rt=0

=====================================================================

New to NPG: Cell Death & Disease
http://links.ealert.nature.com/ctt?kn=60&m=34784146&r=MTc2MzIyNTA1NQS2&b=2&j=NzE5ODkyODkS1&mt=1&rt=0

Online. Open access. Translational cell death.

Sign up today for Cell Death & Disease's ToC-alert at
http://links.ealert.nature.com/ctt?kn=153&m=34784146&r=MTc2MzIyNTA1NQS2&b=2&j=NzE5ODkyODkS1&mt=1&rt=0.

=====================================================================

You have been sent this Table of Contents Alert because you have
opted in to receive it.
You can change or discontinue your e-mail alerts at any time, by
modifying your preferences on your nature.com account at:
http://links.ealert.nature.com/ctt?kn=57&m=34784146&r=MTc2MzIyNTA1NQS2&b=2&j=NzE5ODkyODkS1&mt=1&rt=0
(You will need to log in to be recognised as a nature.com
registrant).

For further technical assistance, please contact our registration
department:
registration@nature.com

For print subscription enquiries, please contact our subscription
department:
subscriptions@nature.com

For other enquiries, please contact customer feedback department:
feedback@nature.com

Nature Publishing Group | 75 Varick Street, 9th Floor | New York
| NY 10013-1917 | USA

Nature Publishing Group's worldwide offices:
London - Paris - Munich - New Delhi - Tokyo - Melbourne - San Diego
- San Francisco - Washington - New York - Boston

Macmillan Publishers Limited is a company incorporated in England
and Wales under company number 785998 and whose registered office
is located at Brunel Road, Houndmills, Basingstoke,
Hampshire RG21 6XS.

=====================================================================

British Journal of Cancer - Table of Contents alert Volume 102 Issue 8

2010-04-14T05:39:00.001-07:00

BRITISH JOURNAL OF CANCER

Volume 102 Number 8
Published online 13 April 2010 (1201 - 1312)

---------------------------------------------------------------------

To Enrich or Not to Enrich. Join Agilent and Science/AAAS for a webinar
on how target enrichment can enhance your research. With target enrichment,
sequence only the regions that matter, making next gen research
orders-of-magnitude more efficient and affordable. Learn how others are
using target enrichment to solve next gen challenges at
http://links.ealert.nature.com/ctt?kn=6&m=34782848&r=MTc2MDAwMTgxNgS2&b=2&j=NzE5NzYxMzAS1&mt=1&rt=0.

---------------------------------------------------------------------
---------------------------------------------------------------------

Visit the journal online at http://links.ealert.nature.com/ctt?kn=66&m=34782848&r=MTc2MDAwMTgxNgS2&b=2&j=NzE5NzYxMzAS1&mt=1&rt=0 to view the latest
research and access selected articles FREE of charge.
---------------------------------------------------------------------
----------------------
CLINICAL STUDIES
----------------------
Predicting the risk of endometrial cancer in postmenopausal women presenting
with vaginal bleeding: the Norwich DEFAB risk assessment tool
N Burbos, P Musonda, I Giarenis, A M Shiner, P Giamougiannis, E P Morris
and J J Nieto
Abstract: http://links.ealert.nature.com/ctt?kn=7&m=34782848&r=MTc2MDAwMTgxNgS2&b=2&j=NzE5NzYxMzAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=37&m=34782848&r=MTc2MDAwMTgxNgS2&b=2&j=NzE5NzYxMzAS1&mt=1&rt=0

Megestrol acetate versus metronomic cyclophosphamide in patients having
exhausted all effective therapies under standard care
N Penel, S Clisant, E Dansin, C Desauw, M Degardin, L Mortier, M Vanhuyse,
F Bonodeau, C Fournier, J-L Cazin and A Adenis
Abstract: http://links.ealert.nature.com/ctt?kn=36&m=34782848&r=MTc2MDAwMTgxNgS2&b=2&j=NzE5NzYxMzAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=35&m=34782848&r=MTc2MDAwMTgxNgS2&b=2&j=NzE5NzYxMzAS1&mt=1&rt=0

Determinants of survival in patients with brain metastases from
cutaneous melanoma
M Staudt, K Lasithiotakis, U Leiter, F Meier, T Eigentler, M Bamberg,
M Tatagiba, P Brossart and C Garbe
Abstract: http://links.ealert.nature.com/ctt?kn=43&m=34782848&r=MTc2MDAwMTgxNgS2&b=2&j=NzE5NzYxMzAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=42&m=34782848&r=MTc2MDAwMTgxNgS2&b=2&j=NzE5NzYxMzAS1&mt=1&rt=0

Clinical responses observed with imatinib or sorafenib in melanoma
patients expressing mutations in KIT
D Handolias, A L Hamilton, R Salemi, A Tan, K Moodie, L Kerr,
A Dobrovic and G A McArthur
Abstract: http://links.ealert.nature.com/ctt?kn=40&m=34782848&r=MTc2MDAwMTgxNgS2&b=2&j=NzE5NzYxMzAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=39&m=34782848&r=MTc2MDAwMTgxNgS2&b=2&j=NzE5NzYxMzAS1&mt=1&rt=0

----------------------
TRANSLATIONAL THERAPEUTICS
----------------------
|[alpha]|-Tocopheryl succinate promotes selective cell death induced by
vitamin K3 in combination with ascorbate
M Tomasetti, E Strafella, S Staffolani, L Santarelli, J Neuzil and
R Guerrieri
Abstract: http://links.ealert.nature.com/ctt?kn=84&m=34782848&r=MTc2MDAwMTgxNgS2&b=2&j=NzE5NzYxMzAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=86&m=34782848&r=MTc2MDAwMTgxNgS2&b=2&j=NzE5NzYxMzAS1&mt=1&rt=0

EGFR/HER2 inhibitor AEE788 increases ER-mediated transcription in
HER2/ER-positive breast cancer cells but functions synergistically
with endocrine therapy
A H Evans, S Pancholi, I Farmer, A Thornhill, D B Evans, S R Johnston,
M Dowsett and L-A Martin
Abstract: http://links.ealert.nature.com/ctt?kn=22&m=34782848&r=MTc2MDAwMTgxNgS2&b=2&j=NzE5NzYxMzAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=24&m=34782848&r=MTc2MDAwMTgxNgS2&b=2&j=NzE5NzYxMzAS1&mt=1&rt=0

Three dysregulated miRNAs control kallikrein 10 expression and cell
proliferation in ovarian cancer
N M A White, T-F F Chow, S Mejia-Guerrero, M Diamandis, Y Rofael,
H Faragalla, M Mankaruous, M Gabril, A Girgis and G M Yousef
Abstract: http://links.ealert.nature.com/ctt?kn=23&m=34782848&r=MTc2MDAwMTgxNgS2&b=2&j=NzE5NzYxMzAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=26&m=34782848&r=MTc2MDAwMTgxNgS2&b=2&j=NzE5NzYxMzAS1&mt=1&rt=0

Oncogenic KRAS sensitises colorectal tumour cells to chemotherapy by
p53-dependent induction of Noxa
M T de Bruijn, D A E Raats, F J H Hoogwater, W J van Houdt, K Cameron,
J P Medema, I H M Borel Rinkes and O Kranenburg
Abstract: http://links.ealert.nature.com/ctt?kn=25&m=34782848&r=MTc2MDAwMTgxNgS2&b=2&j=NzE5NzYxMzAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=31&m=34782848&r=MTc2MDAwMTgxNgS2&b=2&j=NzE5NzYxMzAS1&mt=1&rt=0

----------------------
MOLECULAR DIAGNOSTICS
----------------------
Expansion of CD133+ colon cancer cultures retaining stem cell properties
to enable cancer stem cell target discovery
D D Fang, Y J Kim, C N Lee, S Aggarwal, K McKinnon, D Mesmer, J Norton,
C E Birse, T He, S M Ruben and P A Moore
Abstract: http://links.ealert.nature.com/ctt?kn=28&m=34782848&r=MTc2MDAwMTgxNgS2&b=2&j=NzE5NzYxMzAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=34&m=34782848&r=MTc2MDAwMTgxNgS2&b=2&j=NzE5NzYxMzAS1&mt=1&rt=0

Ovarian cancer stem-like side-population cells are tumourigenic and
chemoresistant
L Hu, C McArthur and R B Jaffe
Abstract: http://links.ealert.nature.com/ctt?kn=33&m=34782848&r=MTc2MDAwMTgxNgS2&b=2&j=NzE5NzYxMzAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=48&m=34782848&r=MTc2MDAwMTgxNgS2&b=2&j=NzE5NzYxMzAS1&mt=1&rt=0

----------------------
GENETICS AND GENOMICS
----------------------
Gene expression in histologically normal epithelium from breast cancer
patients and from cancer-free prophylactic mastectomy patients shares
a similar profile
K Graham, A de las Morenas, A Tripathi, C King, M Kavanah, J Mendez,
M Stone, J Slama, M Miller, G Antoine, H Willers, P Sebastiani and
C L Rosenberg
Abstract: http://links.ealert.nature.com/ctt?kn=62&m=34782848&r=MTc2MDAwMTgxNgS2&b=2&j=NzE5NzYxMzAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=63&m=34782848&r=MTc2MDAwMTgxNgS2&b=2&j=NzE5NzYxMzAS1&mt=1&rt=0

Common germ-line polymorphism of C1QA and breast cancer survival
E M Azzato, A J X Lee, A Teschendorff, B A J Ponder, P Pharoah,
C Caldas and A T Maia
Abstract: http://links.ealert.nature.com/ctt?kn=59&m=34782848&r=MTc2MDAwMTgxNgS2&b=2&j=NzE5NzYxMzAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=60&m=34782848&r=MTc2MDAwMTgxNgS2&b=2&j=NzE5NzYxMzAS1&mt=1&rt=0

Relationship between telomere shortening, genetic instability,
and site of tumour origin in colorectal cancers
E Rampazzo, R Bertorelle, L Serra, L Terrin, C Candiotto, S Pucciarelli,
P Del Bianco, D Nitti and A De Rossi
Abstract: http://links.ealert.nature.com/ctt?kn=57&m=34782848&r=MTc2MDAwMTgxNgS2&b=2&j=NzE5NzYxMzAS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=58&m=34782848&r=MTc2MDAwMTgxNgS2&b=2&j=NzE5NzYxMzAS1&mt=1&rt=0

----------------------
LETTERS TO THE EDITOR
----------------------
The definition of locally advanced pancreatic cancer
N Zanini, M Masetti and E Jovine
http://links.ealert.nature.com/ctt?kn=55&m=34782848&r=MTc2MDAwMTgxNgS2&b=2&j=NzE5NzYxMzAS1&mt=1&rt=0

Reply to: The definition of locally advanced pancreatic cancer
S Boeck and V Heinemann
http://links.ealert.nature.com/ctt?kn=52&m=34782848&r=MTc2MDAwMTgxNgS2&b=2&j=NzE5NzYxMzAS1&mt=1&rt=0

Ongoing under-reporting of clinically relevant safety data in phase II
studies of tyrosine kinase inhibitors
P Schoffski, D H Garfield, A Hercbergs and P Wolter
http://links.ealert.nature.com/ctt?kn=87&m=34782848&r=MTc2MDAwMTgxNgS2&b=2&j=NzE5NzYxMzAS1&mt=1&rt=0

Reply: Ongoing under-reporting of clinically relevant safety data in
phase II studies of tyrosine kinase inhibitors
S Novello, G V Scagliotti, R Rosell, M A Socinski, J Brahmer, J Atkins,
C Pallares, R Burgess, L Tye, P Selaru, E Wang, R Chao and R Govindan
http://links.ealert.nature.com/ctt?kn=75&m=34782848&r=MTc2MDAwMTgxNgS2&b=2&j=NzE5NzYxMzAS1&mt=1&rt=0

----------------------
BOOK REVIEW
----------------------
The HPV Vaccine Controversy. Sex, Cancer, God, and Politics: A Guide for
Parents, Women, Men, and Teenagers
S Franceschi
http://links.ealert.nature.com/ctt?kn=79&m=34782848&r=MTc2MDAwMTgxNgS2&b=2&j=NzE5NzYxMzAS1&mt=1&rt=0

---------------------------------------------------------------------

Ensure your access to British Journal of Cancer

Recommend now at http://links.ealert.nature.com/ctt?kn=64&m=34782848&r=MTc2MDAwMTgxNgS2&b=2&j=NzE5NzYxMzAS1&mt=1&rt=0.

=====================================================================

You have been sent this Table of Contents Alert because you have opted in to receive it.
You can change or discontinue your e-mail alerts at any time, by modifying
your preferences on your nature.com account at:
http://links.ealert.nature.com/ctt?kn=61&m=34782848&r=MTc2MDAwMTgxNgS2&b=2&j=NzE5NzYxMzAS1&mt=1&rt=0
(You will need to log in to be recognised as a nature.com registrant).

For further technical assistance, please contact our registration department:
registration@nature.com

For print subscription enquiries, please contact our subscription department:
subscriptions@nature.com

For other enquiries, please contact customer feedback department:
feedback@nature.com

Nature Publishing Group | 75 Varick Street, 9th Floor | New York | NY 10013-1917 | USA

Nature Publishing Group's worldwide offices:
London - Paris - Munich - New Delhi - Tokyo - Melbourne - San Diego - San Francisco - Washington - New York - Boston

=====================================================================

International Stem Cell Corporation Engages Leading Immunogeneticists to Advance its Industry-first,

2010-04-13T04:34:00.001-07:00

Release #:1468-77264-rl-434148:

International Stem Cell Corporation Engages Leading Immunogeneticists to Advance its Industry-first, Immune-matched Stem Cells

International Stem Cell Corporation (OTCBB:ISCO), www.intlstemcell.com, today added two world-leading immunogeneticists to its scientific advisory board. They and ISCO scientists will study the immune-matching properties of ISCO's human parthenogenetic stem cell (hpSC) technology and the potential for each hpSC-derived therapeutic cell to be an immune-match for millions of people.

Dr. Hans-Dieter Volk, Professor of Immunology and Chair of the Institute of Medical Immunology and Berlin-Brandenburg Center for Regenerative Therapies (BCRT) at Charité Universitätsmedizin in Berlin, and Dr. Matthias von Herrath, Professor at the La Jolla Institute of Allergy and Immunology at University of San Diego, have agreed to join ISCO's scientific advisory board. Both have dedicated their careers to experimental and clinical immunology and are highly regarded immunogenetics experts internationally. They will be most valuable as ISCO attempts to demonstrate the unique immune-matching benefits of the hpSC technology experimentally and in clinical practice.

"We believe that providing human cells that can minimize rejection though immune-matching to the recipient is one of the most important tasks in developing effective regenerative medicine therapies," says Dr. Simon Craw, Vice President at ISCO. "We look forward to Drs. Volk and von Herrath helping us try to demonstrate how that need can be met with our parthenogenetic stem cells."

Embryonic stem cells (hESC) almost invariably have different forms of genes (called "alleles") at each genetic position of the paternal and maternal chromosomes, i.e. they are "heterozygous." This includes the human leukocyte antigen ("HLA") genes that are largely responsible for the distinction between "self" and "foreign," and thus acceptance or rejection of transplants. Since hESC are derived from fertilized embryos, they carry the genes of a unique individual, thus the therapeutic cells derived from hESC will carry HLA alleles that can be recognized as foreign and be rejected by most patients unless they receive immunosuppressive therapy. Such therapy is costly, has significant side effects, and often is disabling in the long term.

Like most individuals in the population, induced pluripotent stem cells ("iPS" cells) and adult stem cells are also predominantly heterozygous because they carry paternal and maternal chromosomes. They are a perfect immune match to the patient they came from and are therefore typically administered back to that same individual ("autologous therapy"). However, they would likely be rejected by most other recipients. Autologous therapy is time-consuming and expensive, which goes against the cost containment pressures globally. In addition, the quality of the therapy is directly related to the ability to secure clinically sufficient numbers of functional cells from the patient, which often poses a significant problem in clinical practice.

In contrast, the hpSCs developed by ISCO are derived from unfertilized eggs ("oocytes") that have been shown in peer-reviewed journals to exhibit unlimited proliferation potential and are pluripotent (can become cells from all three germ layers that form a human being). Most significantly, hpSC can be created in a "homozygous" state, where the alleles, including the HLA alleles, are the same at each genetic position. When these HLA alleles are also found with a high frequency in a population, these "HLA-homozygous" stem cells and their therapeutic derivatives have the potential to be immune matched to millions of people. For example, ISCO's first homozygous stem cell line with high-frequency HLA alleles has the potential to be immune matched to an estimated 75 million people worldwide.

Dr. Volk says: "Using my experience from transplantation immunology and medicine during the past three decades, I am very pleased to help ISCO in their efforts to make its hpSC technology a clinical reality where therapeutic cell derivatives will be immune matches for millions of people worldwide." Dr. von Herrath continues: "While stem cell technologies generally offer great regenerative potential, most clinical applications will be limited by immune rejection. I look much forward to joining ISCO in their quest for making stem cell-derived therapy a practical and attractive clinical option for many degenerative diseases."

Besides the immunogenetic developments, ISCO is advancing its hpSC technology into the differentiation of hpSC into therapeutic cells and tissues and into the establishment of processes and facilities to produce clinical-grade cells. The company is seeking to demonstrate the therapeutic potential of its hpSC technology as a safe, efficient, and superior alternative to other sources of stem cells for human therapy.

ABOUT INTERNATIONAL STEM CELL CORPORATION (ISCO.OB):

International Stem Cell Corporation is a California-based biotechnology company focused on therapeutic and research products. ISCO's core technology, parthenogenesis, results in creation of pluripotent human stem cells from unfertilized oocytes (eggs). hpSCs avoid ethical issues associated with the use or destruction of viable human embryos. ISCO scientists have created the first parthenogenic, homozygous stem cell line that can be a source of therapeutic cells with minimal immune rejection after transplantation into hundreds of millions of individuals of differing sexes, ages and racial groups. This offers the potential to create the first true stem cell bank, UniStemCell™, while avoiding the ethical issue of using fertilized eggs. ISCO also produces and markets specialized cells and growth media for therapeutic research worldwide through its subsidiary Lifeline Cell Technology. More information is available at ISCO's website, www.internationalstemcell.com.

To subscribe to receive ongoing corporate communications please click on the following link: http://www.b2i.us/irpass.asp?BzID=1468&to=ea&s=0.

FORWARD-LOOKING STATEMENTS

Statements pertaining to anticipated technological developments and therapeutic applications, and other opportunities for the company and its subsidiary, along with other statements about the future expectations, beliefs, goals, plans, or prospects expressed by management constitute forward-looking statements. Any statements that are not historical fact (including, but not limited to statements that contain words such as "will," "should," "believes," "plans," "anticipates," "expects," "estimates") should also be considered to be forward-looking statements. Forward-looking statements involve risks and uncertainties, including, without limitation, risks inherent in the development and/or commercialization of potential products, uncertainty in the results of clinical trials or regulatory approvals, need and ability to obtain future capital, application of capital resources among competing uses, and maintenance of intellectual property rights. Actual results may differ materially from the results anticipated in these forward-looking statements and as such should be evaluated together with the many uncertainties that affect the company's business, particularly those mentioned in the cautionary statements found in the company's Securities and Exchange Commission filings. The company disclaims any intent or obligation to update these forward-looking statements.

Key Words: Stem Cells, Biotechnology, Parthenogenesis

International Stem Cell Corporation
Kenneth C. Aldrich, Chairman
760-940-6383
kaldrich@intlstemcell.com
or
Brian Lundstrom, President
760-640-6383
bl@intlstemcell.com

My InvestorPass

Market Data

More Information

Latest PhD Studentships - 13 April 2010

2010-04-12T20:02:00.001-07:00

Welcome to the FindAPhD weekly Newsletter. Listed below are the latest research projects to be advertised on FindAPhD.com.

University of Nottingham
Innate immune regulation in multiple sclerosis and its animal models: the role of plasmacytoid dendritic cells.

University of Nottingham
Neural network interactions underlying emotional learning and memory: Integrating experimental and theoretical approaches

University of York
Spintronic materials on the nanoscale

University of York
In search of 100% Spin Polarized Materials

University of Huddersfield
ESTIMATION OF RAILWAY VEHICLE DYNAMIC PARAMETERS USING MOTOR DRIVE BEHAVIOUR

University of Huddersfield
MODELLING RAIL-WHEEL CONTACT IN ROLLING RAILWAY VEHICLES

Brighton & Sussex Medical School
Novel mechanisms of gene regulation in testis stem cells

Brighton & Sussex Medical School
Mechanisms of restricted, repetitive and stereotyped patterns of behaviour, interests and activities in Asperger Syndrome.

Newcastle University
Studentship in Age Related Eye Disease

National Institute for Biological Standards and Control
Project Details: Cellular reprogramming; induced pluripotent stem cells as a therapy for type-1 diabetes.

University of East Anglia
Examining the threat of climate change to groundwater resources in south-east England

University of Bath
PhD Studentship in Lipid Membrane/Protein Interactions

University of Birmingham
Effective Interventions with Offenders

University of Glasgow
BBSRC Scholarship - Drivers of colonic propionate production and its systemic availability in humans

University of Liverpool
Improved Methods for the Preparation of Fluorinated Drugs

Many more projects have been added this week! Click here to view them all!

Kind regards,

The FindAPhD.com Team

Thinking of a Masters degree instead?
FindAMasters.com lists 1000s of Masters in all subjects!

Please click here if you would like to unsubscribe from the FindAPhD.com Newsletter