Stem Cell

materials@nature contents: 22 April 2010

manojhind2001us@gmail.com (Manoj Kumar Valluru) — Thu, 22 Apr 2010 11:00:40 PDT

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Nature Nanotechnology Volume 5 No 4 pp237-309
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-------------------------------
Editorial
-------------------------------

The weight of evidence
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News Feature
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Toxicology: The big test for bisphenol A
http://links.ealert.nature.com/ctt?kn=133&m=34812055&r=MTc2MzU1NDQxMAS2&b=2&j=NzI0NDU4NTMS1&mt=1&rt=0

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News and views
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Materials science: A cloak of liquidity
http://links.ealert.nature.com/ctt?kn=113&m=34812055&r=MTc2MzU1NDQxMAS2&b=2&j=NzI0NDU4NTMS1&mt=1&rt=0

-------------------------------
Letters
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Substrate-enhanced supercooling in AuSi eutectic droplets
T. U. Sch�lli, R. Daudin, G. Renaud, A. Vaysset, O. Geaymond
& A. Pasturel
http://links.ealert.nature.com/ctt?kn=112&m=34812055&r=MTc2MzU1NDQxMAS2&b=2&j=NzI0NDU4NTMS1&mt=1&rt=0

Super-resolution biomolecular crystallography with low-resolution data
Gunnar F. Schr�der, Michael Levitt & Axel T. Brunger
http://links.ealert.nature.com/ctt?kn=109&m=34812055&r=MTc2MzU1NDQxMAS2&b=2&j=NzI0NDU4NTMS1&mt=1&rt=0

A single-layer wide-angle negative-index metamaterial at visible
frequencies
Stanley P. Burgos, Rene de Waele, Albert Polman & Harry A. Atwater
http://links.ealert.nature.com/ctt?kn=146&m=34812055&r=MTc2MzU1NDQxMAS2&b=2&j=NzI0NDU4NTMS1&mt=1&rt=0

Complementary resistive switches for passive nanocrossbar memories
Eike Linn, Roland Rosezin, Carsten K�geler & Rainer Waser
http://links.ealert.nature.com/ctt?kn=21&m=34812055&r=MTc2MzU1NDQxMAS2&b=2&j=NzI0NDU4NTMS1&mt=1&rt=0

Understanding amyloid aggregation by statistical analysis of atomic
force microscopy images
Jozef Adamcik, Jin-Mi Jung, J�r�me Flakowski, Paolo De Los Rios,
Giovanni Dietler & Raffaele Mezzenga
http://links.ealert.nature.com/ctt?kn=48&m=34812055&r=MTc2MzU1NDQxMAS2&b=2&j=NzI0NDU4NTMS1&mt=1&rt=0

Observation and control of blinking nitrogen-vacancy centres in
discrete nanodiamonds
C. Bradac et al.
http://links.ealert.nature.com/ctt?kn=47&m=34812055&r=MTc2MzU1NDQxMAS2&b=2&j=NzI0NDU4NTMS1&mt=1&rt=0

Biologically templated photocatalytic nanostructures for sustained
light-driven water oxidation
Yoon Sung Nam et al.
http://links.ealert.nature.com/ctt?kn=51&m=34812055&r=MTc2MzU1NDQxMAS2&b=2&j=NzI0NDU4NTMS1&mt=1&rt=0

Integrated elastomeric components for autonomous regulation of sequential
and oscillatory flow switching in microfluidic devices
Bobak Mosadegh et al.
http://links.ealert.nature.com/ctt?kn=152&m=34812055&r=MTc2MzU1NDQxMAS2&b=2&j=NzI0NDU4NTMS1&mt=1&rt=0

-------------------------------
Articles
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The thermodynamic origin of hysteresis in insertion batteries
Wolfgang Dreyer, Janko Jamnik, Clemens Guhlke, Robert Huth, Joze Moskon
& Miran Gaberscek
http://links.ealert.nature.com/ctt?kn=20&m=34812055&r=MTc2MzU1NDQxMAS2&b=2&j=NzI0NDU4NTMS1&mt=1&rt=0

Free-floating ultrathin two-dimensional crystals from sequence-specific
peptoid polymers
Ki Tae Nam et al.
http://links.ealert.nature.com/ctt?kn=23&m=34812055&r=MTc2MzU1NDQxMAS2&b=2&j=NzI0NDU4NTMS1&mt=1&rt=0

Dissolvable films of silk fibroin for ultrathin conformal
bio-integrated electronics
Dae-Hyeong Kim et al.
http://links.ealert.nature.com/ctt?kn=22&m=34812055&r=MTc2MzU1NDQxMAS2&b=2&j=NzI0NDU4NTMS1&mt=1&rt=0

State-selective dissociation of a single water molecule on an ultrathin
MgO film
Hyung-Joon Shin et al.
http://links.ealert.nature.com/ctt?kn=24&m=34812055&r=MTc2MzU1NDQxMAS2&b=2&j=NzI0NDU4NTMS1&mt=1&rt=0

Tuning payload delivery in tumour cylindroids using gold nanoparticles
Byoungjin Kim, Gang Han, Bhushan J. Toley, Chae-kyu Kim, Vincent M. Rotello
& Neil S. Forbes
http://links.ealert.nature.com/ctt?kn=50&m=34812055&r=MTc2MzU1NDQxMAS2&b=2&j=NzI0NDU4NTMS1&mt=1&rt=0

A double-stranded DNA rotaxane
Damian Ackermann, Thorsten L. Schmidt, Jeffrey S. Hannam,
Chandra S. Purohit, Alexander Heckel & Michael Famulok
http://links.ealert.nature.com/ctt?kn=53&m=34812055&r=MTc2MzU1NDQxMAS2&b=2&j=NzI0NDU4NTMS1&mt=1&rt=0

Logic implementations using a single nanoparticle?protein hybrid
Izhar Medalsy et al.
http://links.ealert.nature.com/ctt?kn=52&m=34812055&r=MTc2MzU1NDQxMAS2&b=2&j=NzI0NDU4NTMS1&mt=1&rt=0

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Oncogene - Table of Contents alert Volume 29 Issue 16

manojhind2001us@gmail.com (Manoj Kumar Valluru) — Thu, 22 Apr 2010 11:00:40 PDT

ONCOGENE

April 2010 Volume 29 Number 16, pp 2309 - 2456

-----------------------------------------------------------------------
Nature Communications - Now Live!

Nature Communications is a new online-only, multidisciplinary journal
with open access options. Dedicated to publishing high quality primary
research in all areas of the biological, physical and chemical sciences,
articles represent important advances of significance to specialists
within each field.

To celebrate the launch, ALL articles are available to access FREE* at
http://links.ealert.nature.com/ctt?kn=13&m=34811813&r=MTc2ODI0Mjc1MwS2&b=2&j=NzI0NDMxNDES1&mt=1&rt=0

*Free access to subscribed-access manuscripts is available until
September 30th, 2010.

----------------------
REVIEW
----------------------
Viral hepatocarcinogenesis
W-L Tsai and R T Chung
Abstract: http://links.ealert.nature.com/ctt?kn=49&m=34811813&r=MTc2ODI0Mjc1MwS2&b=2&j=NzI0NDMxNDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=64&m=34811813&r=MTc2ODI0Mjc1MwS2&b=2&j=NzI0NDMxNDES1&mt=1&rt=0

----------------------
ORIGINAL ARTICLES
----------------------
AT7519, A novel small molecule multi-cyclin-dependent kinase inhibitor,
induces apoptosis in multiple myeloma via GSK-3[beta] activation and
RNA polymerase II inhibition
L Santo, S Vallet, T Hideshima, D Cirstea, H Ikeda, S Pozzi, K Patel,
Y Okawa, G Gorgun, G Perrone, E Calabrese, M Yule, M Squires, M Ladetto,
M Boccadoro, P G Richardson, N C Munshi, K C Anderson and N Raje
Abstract: http://links.ealert.nature.com/ctt?kn=67&m=34811813&r=MTc2ODI0Mjc1MwS2&b=2&j=NzI0NDMxNDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=60&m=34811813&r=MTc2ODI0Mjc1MwS2&b=2&j=NzI0NDMxNDES1&mt=1&rt=0

Knock in of the AKT1 E17K mutation in human breast epithelial cells does
not recapitulate oncogenic PIK3CA mutations
J Lauring, D P Cosgrove, S Fontana, J P Gustin, H Konishi, A M Abukhdeir,
J P Garay, M Mohseni, G M Wang, M J Higgins, D Gorkin, M Reis, B Vogelstein,
K Polyak, M Cowherd, P J Buckhaults and B H Park
Abstract: http://links.ealert.nature.com/ctt?kn=62&m=34811813&r=MTc2ODI0Mjc1MwS2&b=2&j=NzI0NDMxNDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=58&m=34811813&r=MTc2ODI0Mjc1MwS2&b=2&j=NzI0NDMxNDES1&mt=1&rt=0

Amplification of EGFR T790M causes resistance to an irreversible EGFR
inhibitor
D Ercan, K Zejnullahu, K Yonesaka, Y Xiao, M Capelletti, A Rogers,
E Lifshits, A Brown, C Lee, J G Christensen, D J Kwiatkowski,
J A Engelman and P A Janne
Abstract: http://links.ealert.nature.com/ctt?kn=59&m=34811813&r=MTc2ODI0Mjc1MwS2&b=2&j=NzI0NDMxNDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=54&m=34811813&r=MTc2ODI0Mjc1MwS2&b=2&j=NzI0NDMxNDES1&mt=1&rt=0

Lysine methylation regulates the pRb tumour suppressor protein
S Munro, N Khaire, A Inche, S Carr and N B La Thangue
Abstract: http://links.ealert.nature.com/ctt?kn=55&m=34811813&r=MTc2ODI0Mjc1MwS2&b=2&j=NzI0NDMxNDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=68&m=34811813&r=MTc2ODI0Mjc1MwS2&b=2&j=NzI0NDMxNDES1&mt=1&rt=0

Extracellular matrix-induced transforming growth factor-[beta] receptor
signaling dynamics
N Garamszegi, S P Garamszegi, P Samavarchi-Tehrani, E Walford,
M M Schneiderbauer, J L Wrana and S P Scully
Abstract: http://links.ealert.nature.com/ctt?kn=20&m=34811813&r=MTc2ODI0Mjc1MwS2&b=2&j=NzI0NDMxNDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=21&m=34811813&r=MTc2ODI0Mjc1MwS2&b=2&j=NzI0NDMxNDES1&mt=1&rt=0

Peptide-based interference of the transmembrane domain of neuropilin-1
inhibits glioma growth in vivo
C Nasarre, M Roth, L Jacob, L Roth, E Koncina, A Thien, G Labourdette,
P Poulet, P Hubert, G Cremel, G Roussel, D Aunis and D Bagnard
Abstract: http://links.ealert.nature.com/ctt?kn=22&m=34811813&r=MTc2ODI0Mjc1MwS2&b=2&j=NzI0NDMxNDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=23&m=34811813&r=MTc2ODI0Mjc1MwS2&b=2&j=NzI0NDMxNDES1&mt=1&rt=0

ASAP1 promotes tumor cell motility and invasiveness, stimulates metastasis
formation in vivo, and correlates with poor survival in colorectal cancer
patients
T Muller, U Stein, A Poletti, L Garzia, M Rothley, D Plaumann, W Thiele,
M Bauer, A Galasso, P Schlag, M Pankratz, M Zollo and J P Sleeman
Abstract: http://links.ealert.nature.com/ctt?kn=24&m=34811813&r=MTc2ODI0Mjc1MwS2&b=2&j=NzI0NDMxNDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=25&m=34811813&r=MTc2ODI0Mjc1MwS2&b=2&j=NzI0NDMxNDES1&mt=1&rt=0

Phosphorylation of the mutant K303R estrogen receptor [alpha] at serine
305 affects aromatase inhibitor sensitivity
I Barone, D Iacopetta, K R Covington, Y Cui, A Tsimelzon, A Beyer,
S Ando and S A W Fuqua
Abstract: http://links.ealert.nature.com/ctt?kn=26&m=34811813&r=MTc2ODI0Mjc1MwS2&b=2&j=NzI0NDMxNDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=27&m=34811813&r=MTc2ODI0Mjc1MwS2&b=2&j=NzI0NDMxNDES1&mt=1&rt=0

Role of Mdm4 in drug sensitivity of breast cancer cells
S Lam, K Lodder, A F A S Teunisse, M J W E Rabelink, M Schutte and
A G Jochemsen
Abstract: http://links.ealert.nature.com/ctt?kn=29&m=34811813&r=MTc2ODI0Mjc1MwS2&b=2&j=NzI0NDMxNDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=32&m=34811813&r=MTc2ODI0Mjc1MwS2&b=2&j=NzI0NDMxNDES1&mt=1&rt=0

Cadherin switching and activation of p120 catenin signaling are mediators
of gonadotropin-releasing hormone to promote tumor cell migration and
invasion in ovarian cancer
L W T Cheung, P C K Leung and A S T Wong
Abstract: http://links.ealert.nature.com/ctt?kn=40&m=34811813&r=MTc2ODI0Mjc1MwS2&b=2&j=NzI0NDMxNDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=5&m=34811813&r=MTc2ODI0Mjc1MwS2&b=2&j=NzI0NDMxNDES1&mt=1&rt=0

----------------------
SHORT COMMUNICATIONS
----------------------
Formin-like 2 drives amoeboid invasive cell motility downstream of RhoC
T M Kitzing, Y Wang, O Pertz, J W Copeland and R Grosse
Abstract: http://links.ealert.nature.com/ctt?kn=6&m=34811813&r=MTc2ODI0Mjc1MwS2&b=2&j=NzI0NDMxNDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=1&m=34811813&r=MTc2ODI0Mjc1MwS2&b=2&j=NzI0NDMxNDES1&mt=1&rt=0

Dissection of RAS downstream pathways in melanomagenesis: a role for Ral
in transformation
P J Mishra, L Ha, J Rieker, E V Sviderskaya, D C Bennett, M D Oberst,
K Kelly and G Merlino
Abstract: http://links.ealert.nature.com/ctt?kn=3&m=34811813&r=MTc2ODI0Mjc1MwS2&b=2&j=NzI0NDMxNDES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=8&m=34811813&r=MTc2ODI0Mjc1MwS2&b=2&j=NzI0NDMxNDES1&mt=1&rt=0

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Genes and Immunity - Table of Contents alert Volume 11 Issue 3

manojhind2001us@gmail.com (Manoj Kumar Valluru) — Thu, 22 Apr 2010 11:00:52 PDT

GENES AND IMMUNITY

April 2010 Volume 11 Number 3, pp 199 - 278

=====================================================================

Mucosal Immunology
The official publication of the Society for Mucosal Immunology (SMI)
Indexed by Medline
Mucosal Immunology presents
A focus on the latest developments in understanding allergic disease

This issue brings together reviews on immune activation by allergens,
the role of basophils in driving Th2 immunity, the function of epithelial
cytokines such as TSLP in allergic inflammatory responses, and advances
in understanding Mast cell phenotypes and functions.

http://links.ealert.nature.com/ctt?kn=7&m=34811114&r=MTc2MTE2NTAwMwS2&b=2&j=NzI0MzcxMzkS1&mt=1&rt=0

=====================================================================
----------------------
ORIGINAL ARTICLES
----------------------
Supervised machine learning and logistic regression identifies novel
epistatic risk factors with PTPN22 for rheumatoid arthritis
F B S Briggs, P P Ramsay, E Madden, J M Norris, V M Holers,
T R Mikuls, T Sokka, M F Seldin, P K Gregersen, L A Criswell
and L F Barcellos
Abstract: http://links.ealert.nature.com/ctt?kn=18&m=34811114&r=MTc2MTE2NTAwMwS2&b=2&j=NzI0MzcxMzkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=24&m=34811114&r=MTc2MTE2NTAwMwS2&b=2&j=NzI0MzcxMzkS1&mt=1&rt=0

Genetic variation within the HLA class III influences T1D
susceptibility conferred by high-risk HLA haplotypes
A M Valdes, G Thomson and L F Barcellos the T1DGC
Abstract: http://links.ealert.nature.com/ctt?kn=25&m=34811114&r=MTc2MTE2NTAwMwS2&b=2&j=NzI0MzcxMzkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=17&m=34811114&r=MTc2MTE2NTAwMwS2&b=2&j=NzI0MzcxMzkS1&mt=1&rt=0

Quantitative lymphatic vessel trait analysis suggests Vcam1 as
candidate modifier gene of inflammatory bowel disease
G Jurisic, J P Sundberg, A Bleich, E H Leiter, K W Broman,
G Buechler, L Alley, D Vestweber and M Detmar
Abstract: http://links.ealert.nature.com/ctt?kn=20&m=34811114&r=MTc2MTE2NTAwMwS2&b=2&j=NzI0MzcxMzkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=21&m=34811114&r=MTc2MTE2NTAwMwS2&b=2&j=NzI0MzcxMzkS1&mt=1&rt=0

New genetic associations detected in a host response study to
hepatitis B vaccine
S Davila, F E M Froeling, A Tan, C Bonnard, G J Boland, H Snippe,
M L Hibberd and M Seielstad
Abstract: http://links.ealert.nature.com/ctt?kn=22&m=34811114&r=MTc2MTE2NTAwMwS2&b=2&j=NzI0MzcxMzkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=26&m=34811114&r=MTc2MTE2NTAwMwS2&b=2&j=NzI0MzcxMzkS1&mt=1&rt=0

Finemapping of the arthritis QTL Pia7 reveals co-localization with
Oia2 and the APLEC locus
C Rintisch, T Kelkka, U Norin, J C Lorentzen, P Olofsson and
R Holmdahl
Abstract: http://links.ealert.nature.com/ctt?kn=27&m=34811114&r=MTc2MTE2NTAwMwS2&b=2&j=NzI0MzcxMzkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=28&m=34811114&r=MTc2MTE2NTAwMwS2&b=2&j=NzI0MzcxMzkS1&mt=1&rt=0

Involvement of T-cell receptor-[beta] alterations in the development
of otosclerosis linked to OTSC2
I Schrauwen, K Venken, K Vanderstraeten, M Thys, J-J Hendrickx,
E Fransen, L Van Laer, P J Govaerts, M Verstreken, I Schatteman,
P Stinissen, N Hellings and G Van Camp
Abstract: http://links.ealert.nature.com/ctt?kn=37&m=34811114&r=MTc2MTE2NTAwMwS2&b=2&j=NzI0MzcxMzkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=38&m=34811114&r=MTc2MTE2NTAwMwS2&b=2&j=NzI0MzcxMzkS1&mt=1&rt=0

Immunoglobulin heavy chain variable region genes contribute to the
induction of thyroid-stimulating antibodies in recombinant inbred mice
B Rapoport, R W Williams, C-R Chen and S M McLachlan
Abstract: http://links.ealert.nature.com/ctt?kn=32&m=34811114&r=MTc2MTE2NTAwMwS2&b=2&j=NzI0MzcxMzkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=31&m=34811114&r=MTc2MTE2NTAwMwS2&b=2&j=NzI0MzcxMzkS1&mt=1&rt=0

STAT3 locus in inflammatory bowel disease and multiple
sclerosis susceptibility
M C Cenit, A Alcina, A Marquez, J L Mendoza, M Diaz-Rubio,
V de las Heras, G Izquierdo, R Arroyo, O Fernandez, E G de la Concha,
F Matesanz and E Urcelay
Abstract: http://links.ealert.nature.com/ctt?kn=30&m=34811114&r=MTc2MTE2NTAwMwS2&b=2&j=NzI0MzcxMzkS1&mt=1&rt=0
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Specific gene expression signature associated with development of
autoimmune type-I diabetes using whole-blood microarray analysis
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Nature 22 April 2010 Volume 464 Number 7292 pp1103-1238

manojhind2001us@gmail.com (Manoj Kumar Valluru) — Thu, 22 Apr 2010 11:01:40 PDT

NATURE

22 April 2010 Volume 464 Number 7292, pp 1103 - 1238

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Nature News & Views Forum

From April 1st, Nature introduced an occasional variation on the
traditional format of News & Views articles. In this new type of
article - called News & Views Forum - two separate opinions about a
paper are given, with the aim of offering diversity of views on
selected high-impact research.

The latest News & Views Forum relates to a study reporting direct
reprogramming of pancreatic α cells to β cells. Kenneth Zaret writes
about the science behind this process, whereas Morris White discusses
what the findings mean for the treatment of diabetes.

Access the News & Views Forum article in this week's Nature.

http://links.ealert.nature.com/ctt?kn=89&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0
=====================================================================

----------------------
EDITORIALS
----------------------
Nuclear ambition p1103
The US weapons labs need to develop a twenty-first-century vision of
deterrence -- one that does not include making new bombs.
doi:10.1038/4641103a
http://links.ealert.nature.com/ctt?kn=96&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

The weight of evidence pp1103-1104
Better chemical-control legislation is a good start, but scientific
reform should parallel legal reform.
doi:10.1038/4641103b
http://links.ealert.nature.com/ctt?kn=94&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

Time for libel-law reform p1104
Simon Singh's recent libel result is a victory for science, but the
real fight lies ahead.
doi:10.1038/4641104a
http://links.ealert.nature.com/ctt?kn=85&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

----------------------
RESEARCH HIGHLIGHTS
----------------------
Planetary science: Moon grab p1106
doi:10.1038/4641106a
http://links.ealert.nature.com/ctt?kn=60&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

Neuroscience: Relief from pain p1106
doi:10.1038/4641106b
http://links.ealert.nature.com/ctt?kn=65&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

Biomaterials: Electronics on the brain p1106
doi:10.1038/4641106c
http://links.ealert.nature.com/ctt?kn=72&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

Cultural evolution: High fidelity p1106
doi:10.1038/4641106d
http://links.ealert.nature.com/ctt?kn=77&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

Cell biology: Toxin tackle p1106
doi:10.1038/4641106e
http://links.ealert.nature.com/ctt?kn=123&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

Chemistry: Plumbing carbon rings pp1106-1107
doi:10.1038/4641106f
http://links.ealert.nature.com/ctt?kn=108&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

Cancer biology: Cells combat chemo p1107
doi:10.1038/4641107a
http://links.ealert.nature.com/ctt?kn=102&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

Neuroscience: Sharpening social skills p1107
doi:10.1038/4641107b
http://links.ealert.nature.com/ctt?kn=120&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

Climate change: Fewer, taller, fiercer p1107
doi:10.1038/4641107c
http://links.ealert.nature.com/ctt?kn=114&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

Immunology: Inflammatory good guys p1107
doi:10.1038/4641107d
http://links.ealert.nature.com/ctt?kn=43&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

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JOURNAL CLUB
----------------------
Journal club p1107
Kevin Mitchell
doi:10.1038/4641107e
http://links.ealert.nature.com/ctt?kn=40&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

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NEWS
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News briefing: 22 April 2010 pp1108-1109
The week in science
doi:10.1038/4641108a
http://links.ealert.nature.com/ctt?kn=222&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

A shot in the arm for cancer vaccines? pp1110-1111
Researchers anxiously await a decision by US regulators on a
controversial cancer therapy.
Heidi Ledford
doi:10.1038/4641110a
http://links.ealert.nature.com/ctt?kn=242&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

No gain from brain training p1111
Computerized mental workouts don't boost mental skills, study claims.
Alla Katsnelson
doi:10.1038/4641111a
http://links.ealert.nature.com/ctt?kn=240&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

Portrait of a year-old pandemic pp1112-1113
'Swine flu' isn't over yet, but it already holds lessons for the
future.
Declan Butler
doi:10.1038/4641112a
http://links.ealert.nature.com/ctt?kn=238&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

Undersea project delivers data flood p1115
Sea-floor observatory in the Pacific Ocean to provide terabytes of
data.
Nicola Jones
doi:10.1038/4641115a
http://links.ealert.nature.com/ctt?kn=236&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

Crucial data on REACH not disclosed pp1116-1117
Disagreement flares up over the number of animals required to
implement Europe's chemical-safety law.
Natasha Gilbert
doi:10.1038/4641116a
http://links.ealert.nature.com/ctt?kn=269&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

----------------------
NEWS FEATURES
----------------------
Environmental science: New life for the Dead Sea? pp1118-1120
A conduit from the Red Sea could restore the disappearing Dead Sea
and slake the region's thirst. But such a massive engineering project
could have untold effects, reports Josie Glausiusz.
Josie Glausiusz
doi:10.1038/4641118a
http://links.ealert.nature.com/ctt?kn=266&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

Toxicology: The big test for bisphenol A pp1122-1124
After years of wrangling over the chemical's toxicity, researchers
are charting a new way forwards. Brendan Borrell investigates how the
debate has reshaped environmental-health studies.
Brendan Borrell
doi:10.1038/4641122a
http://links.ealert.nature.com/ctt?kn=264&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

----------------------
CORRESPONDENCE
----------------------
Climate policy: role of scientists in public advocacy p1125
Stephen H. Schneider
doi:10.1038/4641125a
http://links.ealert.nature.com/ctt?kn=36&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

Climate policy: dissent over moral as well as factual issues p1125
Gregor Betz
doi:10.1038/4641125b
http://links.ealert.nature.com/ctt?kn=38&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

What users really want to know from university ratings p1125
Jimmy J. Zhuang, Annie X. Wang and Joyce Y. Zhang
doi:10.1038/4641125c
http://links.ealert.nature.com/ctt?kn=32&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

African students value the results of studying in China p1125
Kenneth King
doi:10.1038/4641125d
http://links.ealert.nature.com/ctt?kn=34&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

Actions speak louder than words to prevent language extinctions p1125
Yoshina Gautam and Aashish Jha
doi:10.1038/4641125e
http://links.ealert.nature.com/ctt?kn=51&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

----------------------
OPINION
----------------------
Copenhagen Accord pledges are paltry pp1126-1128
Current national emissions targets can't limit global warming to 2
[deg]C, calculate Joeri Rogelj, Malte Meinshausen and colleagues --
they might even lock the world into exceeding 3 [deg]C warming.
Joeri Rogelj et al.
doi:10.1038/4641126a
http://links.ealert.nature.com/ctt?kn=49&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

----------------------
BOOKS AND ARTS
----------------------
Building life from the bottom up pp1129-1130
Engineering biological systems and organisms is a costly team effort
and may be incompatible with an open-source regulatory environment,
finds Michael A. Goldman.
Michael A. Goldman reviews Biology is Technology: The Promise, Peril,
and New Business of Engineering Life by Robert H. Carlson
doi:10.1038/4641129a
http://links.ealert.nature.com/ctt?kn=47&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

Why twins age differently pp1130-1131
Michael Sargent reviews Epigenetics of Aging by Trygve O. Tollefsbol
doi:10.1038/4641130a
http://links.ealert.nature.com/ctt?kn=45&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

Where the wilderness line blurs p1131
Emma Marris reviews Living Through the End of Nature: The Future of
American Environmentalism by Paul Wapner
doi:10.1038/4641131a
http://links.ealert.nature.com/ctt?kn=44&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

----------------------
NEWS AND VIEWS
----------------------
Diabetes forum: Extreme makeover of pancreatic [alpha]-cells
pp1132-1133
Most insulin-secreting pancreatic [beta]-cells are irreplaceably lost
in type 1 diabetes. In a mouse model, pancreatic [alpha]-cells seem
to sacrifice their identity to replenish the low stock of [beta]-cells.
Two experts discuss what this means for understanding the basic cell
biology involved and its relevance to treating diabetes.
Kenneth S. Zaret and Morris F. White
doi:10.1038/4641132a
http://links.ealert.nature.com/ctt?kn=89&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

Quantum measurement: A condensate's main squeeze pp1133-1134
Entanglement between particles permits the quantum uncertainty in one
variable to be reduced at the cost of increasing that in another.
Condensates are an ideal system in which this technique can be studied.
Charles A. Sackett
doi:10.1038/4641133a
http://links.ealert.nature.com/ctt?kn=2&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

Neuroscience: Signals far and away pp1134-1136
The neocortex of the mammalian brain mediates functions such as
sensory perception and ultimately consciousness and language. The
spread of local signals across large distances in this brain region
has now been clarified.
Dirk Feldmeyer
doi:10.1038/4641134a
http://links.ealert.nature.com/ctt?kn=7&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

Chemistry: Not just any old anion pp1136-1137
Unlike its neighbours on the right-hand side of the periodic table,
boron barely forms an anion. A new trick has been established that
allows it to do so, enabling a highly unusual complex to be prepared.
Kyoko Nozaki
doi:10.1038/4641136a
http://links.ealert.nature.com/ctt?kn=25&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

Materials science: A cloak of liquidity pp1137-1138
Droplets of a liquid alloy on a silicon surface can rearrange the
surface atoms so that they mimic the short-range ordering of atoms in
the alloy. Remarkably, this effect inhibits freezing of the droplets.
A. Lindsay Greer
doi:10.1038/4641137a
http://links.ealert.nature.com/ctt?kn=19&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

50 & 100 years ago p1138
doi:10.1038/4641138b
http://links.ealert.nature.com/ctt?kn=21&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

Infectious disease: Listeria does it again pp1138-1139
Proteins are synthesized by ribosomes, and then commonly undergo
further modifications. A new example of how these host-cell processes
can e subverted by a pathogenic bacterium has come to light.
Julian I. Rood
doi:10.1038/4641138a
http://links.ealert.nature.com/ctt?kn=272&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

Q&A: Animal behaviour: Magnetic-field perception pp1140-1142
The ability to perceive Earth's magnetic field, which at one time was
dismissed as a physical impossibility, is now known to exist in
diverse animals. The receptors for the magnetic sense remain elusive.
But it seems that at least two underlying mechanisms exist --
sometimes in the same organism.
Kenneth J. Lohmann
doi:10.1038/4641140a
http://links.ealert.nature.com/ctt?kn=279&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

----------------------
ARTICLES
----------------------
Generation of a novel wing colour pattern by the Wingless morphogen
pp1143-1148
Here, the generation and evolution of the complex spotted wing pattern
of Drosophila guttifera are investigated. The findings show that wing
spots are induced by the Wingless morphogen, and that the elaborate
spot pattern evolved from simpler schemes by co-option of Wingless
expression at new sites. This type of process is likely to occur in
other animals, too.
Thomas Werner, Shigeyuki Koshikawa, Thomas M. Williams and
Sean B. Carroll
doi:10.1038/nature08896
Abstract: http://links.ealert.nature.com/ctt?kn=261&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=288&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

Conversion of adult pancreatic [agr]-cells to [bgr]-cells after
extreme [bgr]-cell loss pp1149-1154
In the pancreas, insulin-producing [beta]-cells are long-lived and
generally replicate seldom. They can do so, however, after increased
metabolic demand or after injury. Here, a new transgenic model is
developed in which [beta]-cells are nearly completely ablated in mice.
If given insulin, these mice survive, and grow new [beta]-cells.
Lineage-tracing shows that these new [beta]-cells come from
[alpha]-cells, revealing a previously disregarded degree of pancreatic
cell plasticity.
Fabrizio Thorel et al.
doi:10.1038/nature08894
Abstract: http://links.ealert.nature.com/ctt?kn=276&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=11&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

Lateral competition for cortical space by layer-specific horizontal
circuits pp1155-1160
A common anatomical feature of the sensory cortex in many species is
that neurons with similar features cluster into vertically orientated
domains spanning all layers of the cortex. Moreover, neurons in one
domain modulate neurons in neighbouring domains through horizontal
connections. A combination of techniques has now been used to show
that such horizontal projections suppress layers of cortex devoted
to processing inputs, but facilitate layers devoted to outputs.
Hillel Adesnik and Massimo Scanziani
doi:10.1038/nature08935
Abstract: http://links.ealert.nature.com/ctt?kn=271&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=28&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

----------------------
LETTERS
----------------------
Possible thermochemical disequilibrium in the atmosphere of the
exoplanet GJ 436b pp1161-1164
Here, the atmosphere of the extrasolar planet GJ 436b is studied
during its 'secondary eclipse'. The findings reveal the presence of
some H2O and traces of CO2. The best-fit compositional models contain
a high CO abundance and a substantial methane deficiency relative to
thermochemical equilibrium models for the predicted hydrogen-dominated
atmosphere. Disequilibrium processes such as vertical mixing and
polymerization of methane may be required to explain this small
methane-to-CO ratio.
Kevin B. Stevenson et al.
doi:10.1038/nature09013
Abstract: http://links.ealert.nature.com/ctt?kn=273&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=253&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

Nonlinear atom interferometer surpasses classical precision limit
pp1165-1169
The precision of interferometers -- used in metrology and in the
state-of-the-art time standard -- is generally limited by classical
statistics. Here it is shown that the classical precision limit can
be beaten by using nonlinear atom interferometry with Bose-Einstein
condensates.
C. Gross et al.
doi:10.1038/nature08919
Abstract: http://links.ealert.nature.com/ctt?kn=282&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=5&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

Atom-chip-based generation of entanglement for quantum metrology
pp1170-1173
Atom chips provide a versatile quantum laboratory for experiments
with ultracold atomic gases, but techniques to control atomic
interactions and to generate entanglement have been unavailable so
far. Here, the experimental generation of multi-particle entanglement
on an atom chip is described. The technique is used to produce
spin-squeezed states of a two-component Bose-Einstein condensate,
which should be useful for quantum metrology.
Max F. Riedel et al.
doi:10.1038/nature08988
Abstract: http://links.ealert.nature.com/ctt?kn=284&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=6&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

Substrate-enhanced supercooling in AuSi eutectic droplets
pp1174-1177
Supercooling is a phenomenon by which a liquid remains in its fluid
phase well below its melting point. Supercooling can be inhibited by
the presence of a solid surface, whereby crystalline surfaces cause
adjacent atoms in the liquid to become ordered, inducing crystal
nucleation of the melt. Here it is shown that a particular surface
ordering of gold atoms on top of a silicon substrate can stabilize
the liquid phase of a gold-silicon eutectic droplet, and thus enhance
supercooling.
T. U. Schülli et al.
doi:10.1038/nature08986
Abstract: http://links.ealert.nature.com/ctt?kn=277&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=18&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

Stoichiometric control of organic carbon-nitrate relationships from
soils to the sea pp1178-1181
The accumulation of nitrate in freshwater and coastal marine ecosystems
is one of the consequences of the worldwide production of artificial
fertilizers. Here it is shown that nitrate accumulation in ecosystems
shows consistent and negative nonlinear correlations with organic
carbon availability, along a continuum from soils, through freshwater
systems and coastal margins, to the open ocean. This pattern can be
explained by carbon:nitrate ratios, which influence nitrate
accumulation by regulating microbial processes.
Philip G. Taylor and Alan R. Townsend
doi:10.1038/nature08985
Abstract: http://links.ealert.nature.com/ctt?kn=280&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=216&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

Learning-related fine-scale specificity imaged in motor cortex
circuits of behaving mice pp1182-1186
It is generally accepted that specific neuronal circuits in the
brain's cortex drive behavioural execution, but the relationship
between the performance of a task and the function of a circuit is
unknown. Here, this problem was tackled by using a technique that
allows many neurons within the same circuit to be monitored
simultaneously. The findings indicate that enhanced correlated
activity in specific ensembles of neurons can identify and encode
specific behavioural responses while a task is learned.
Takaki Komiyama et al.
doi:10.1038/nature08897
Abstract: http://links.ealert.nature.com/ctt?kn=289&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=106&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

Genetic analysis of variation in transcription factor binding in
yeast pp1187-1191
Variation in the regulation of gene transcription between individuals
is thought to be a major cause of phenotypic diversity. Here,
individual differences in the binding of transcription-factor
proteins are studied. A well-known transcription factor in the yeast
pheromone pathway is used as an example, and the underlying genetic
loci responsible for variation in its binding are mapped. The study
reveals new insights into the mechanisms of gene regulation, and new
regulators of the yeast pheromone pathway.
Wei Zheng et al.
doi:10.1038/nature08934
Abstract: http://links.ealert.nature.com/ctt?kn=291&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=118&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

Listeria monocytogenes impairs SUMOylation for efficient infection
pp1192-1195
SUMOylation is a post-translational protein modification that affects
many eukaryotic cellular processes. It is shown here that cellular
infection with Listeria monocytogenes induces degradation of one of
the essential SUMOylation enzymes, Ubc9, through a mechanism that
involves a bacterial toxin, listeriolysin O. This effect on
SUMOylation may support efficient infection by Listeria.
David Ribet et al.
doi:10.1038/nature08963
Abstract: http://links.ealert.nature.com/ctt?kn=286&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=281&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

MicroRNA-mediated integration of haemodynamics and Vegf signalling
during angiogenesis pp1196-1200
During embryonic development, blood vessels remodel in response to
blood flow. Here, a genetic pathway is described through which this
mechanosensory stimulus is integrated with early developmental signals
to remodel vessels of the aortic arch in zebrafish. It is found that
the flow-induced transcription factor klf2a is required to induce the
expression of an endothelial-specific microRNA, activating signalling
through the growth factor Vegf.
Stefania Nicoli et al.
doi:10.1038/nature08889
Abstract: http://links.ealert.nature.com/ctt?kn=205&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=59&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

Caspase activation precedes and leads to tangles pp1201-1204
Fibrillar deposits of tau protein (neurofibrillary tangles) are
thought to cause neuronal death in patients with Alzheimer's disease,
and tau-related frontotemporal dementia. Here, however, the opposite
has been found: the activation of executioner caspase enzymes occurs
first, preceding tangle formation by hours to days. Tangle-bearing
neurons seem to be long-lived, indicating that tangles might be 'off
pathway' to acute neuronal death.
Alix de Calignon et al.
doi:10.1038/nature08890
Abstract: http://links.ealert.nature.com/ctt?kn=206&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=67&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

Crystal structure of the FTO protein reveals basis for its substrate
specificity pp1205-1209
The fat mass and obesity-associated (FTO) gene has been associated
with increased body weight. The FTO protein has DNA/RNA demethylase
activity. Here, the crystal structure of human FTO in complex with
the mononucleotide 3-methylthymidine is presented. The structure
provides a basis for understanding the substrate specificity of FTO,
and should serve as a foundation for the design of FTO inhibitors.
Zhifu Han et al.
doi:10.1038/nature08921
Abstract: http://links.ealert.nature.com/ctt?kn=207&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=78&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

Isolation of the elusive supercomplex that drives cyclic electron
flow in photosynthesis pp1210-1213
During photosynthesis, light energy is used by photosystems I and II
to establish electron flow, which ultimately results in the production
of ATP and NADPH. Two modes of electron flow exist, a linear electron
flow and a cyclic electron flow (CEF). The latter pathway generates
more ATP, but its molecular components have been elusive. Here, a
combination of biochemical and spectroscopic techniques has been used
to identify the supercomplex that drives CEF in the green alga
Chlamydomonas reinhardtii.
Masakazu Iwai et al.
doi:10.1038/nature08885
Abstract: http://links.ealert.nature.com/ctt?kn=208&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=164&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

Ku is a 5[prime]-dRP/AP lyase that excises nucleotide damage near
broken ends pp1214-1217
Most agents that generate breaks in DNA leave 'dirty ends' that
cannot be joined immediately; instead, intervening steps are required
to restore the integrity of nucleotides at the break. Here it is
shown that the non-homologous end joining pathway requires a
5[prime]-dRP/AP lyase activity to remove abasic sites at
double-strand breaks. Surprisingly, this activity is catalysed by the
Ku70 protein, which, together with its partner Ku86, had been thought
only to recognize broken DNA ends and to recruit other factors that
process ends.
Steven A. Roberts et al.
doi:10.1038/nature08926
Abstract: http://links.ealert.nature.com/ctt?kn=201&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=168&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

Super-resolution biomolecular crystallography with low-resolution
data pp1218-1222
X-ray crystallography has become the most common way for structural
biologists to obtain the three-dimensional structures of proteins and
protein complexes. However, crystals of large macromolecular complexes
often diffract only weakly (yielding a resolution worse than 4 A), so
new methods that work at such low resolution are needed. Here a new
method is described by which to obtain higher-quality electron
density maps and more accurate molecular models of weakly diffracting
crystals.
Gunnar F. Schroder, Michael Levitt and Axel T. Brunger
doi:10.1038/nature08892
Abstract: http://links.ealert.nature.com/ctt?kn=202&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=194&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

----------------------
TECHNOLOGY FEATURE
----------------------
RNA interference: Homing in on delivery pp1225-1228
The scientific community now seems convinced that small RNAs will
become therapies, if new tools can help these large molecules to make
it safely into cells. Monya Baker reports.
Monya Baker
doi:10.1038/4641225a
http://links.ealert.nature.com/ctt?kn=186&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

RNA interference: From tools to therapies p1225
doi:10.1038/4641225b
http://links.ealert.nature.com/ctt?kn=184&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

RNA interference: MicroRNAs as biomarkers p1227
doi:10.1038/4641227a
http://links.ealert.nature.com/ctt?kn=190&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

RNA interference: Table of suppliers pp1229-1230
doi:10.1038/4641229a
http://links.ealert.nature.com/ctt?kn=188&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

----------------------
NATUREJOBS
----------------------
News
Science outreach scheme ramps up p1233
More than 2,500 US scientists are participating in new initiative.
Karen Kaplan
doi:10.1038/nj7292-1233a
http://links.ealert.nature.com/ctt?kn=128&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

Prospects
The junior senior supervisor p1233
Mentoring students as a young researcher has its own particular
challenges, suggests Fabio Paglieri.
Fabio Paglieri
doi:10.1038/nj7292-1233b
http://links.ealert.nature.com/ctt?kn=132&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

Careers and Recruitment
Making a switch p1234
When inspiration strikes or desperation sets in, a bold few risk
career suicide and move to new fields. Bryn Nelson reports on what
it takes.
Bryn Nelson
doi:10.1038/nj7292-1234a
http://links.ealert.nature.com/ctt?kn=130&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

----------------------
FUTURES
----------------------
Corrective action p1238
Accidents will happen.
John Gilbey
doi:10.1038/4641238a
http://links.ealert.nature.com/ctt?kn=146&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

----------------------
Advance Online Publication
----------------------
20 April 2010
Putting brain training to the test near-final version
Adrian M. Owen et al.
doi:10.1038/nature09042
Abstract: http://links.ealert.nature.com/ctt?kn=203&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0
PDF: http://links.ealert.nature.com/ctt?kn=204&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

21 April 2010
Chemical genetics strategy identifies an HCV NS5A inhibitor with a
potent clinical effect
Min Gao et al.
doi:10.1038/nature08960
Abstract: http://links.ealert.nature.com/ctt?kn=145&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=145&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

Cell signalling by microRNA165/6 directs gene dose-dependent root
cell fate
Annelie Carlsbecker et al.
doi:10.1038/nature08977
Abstract: http://links.ealert.nature.com/ctt?kn=139&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=139&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

Oxidation of methane by a biological dicopper centre
Ramakrishnan Balasubramanian et al.
doi:10.1038/nature08992
Abstract: http://links.ealert.nature.com/ctt?kn=158&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=158&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

An RNA polymerase II- and AGO4-associated protein acts in RNA-directed
DNA methylation
Zhihuan Gao et al.
doi:10.1038/nature09025
Abstract: http://links.ealert.nature.com/ctt?kn=154&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=154&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

18 April 2010
Evolution of self-compatibility in Arabidopsis by a mutation in the
male specificity gene
Takashi Tsuchimatsu et al.
doi:10.1038/nature08927
Abstract: http://links.ealert.nature.com/ctt?kn=151&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=151&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

The scaffold protein Ste5 directly controls a switch-like mating
decision in yeast
Mohan K. Malleshaiah, Vahid Shahrezaei, Peter S. Swain
and Stephen W. Michnick
doi:10.1038/nature08946
Abstract: http://links.ealert.nature.com/ctt?kn=246&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=246&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

X-ray crystal structure of the light-independent protochlorophyllide
reductase
Norifumi Muraki et al.
doi:10.1038/nature08950
Abstract: http://links.ealert.nature.com/ctt?kn=252&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=252&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

Native GABAB receptors are heteromultimers with a family of auxiliary
subunits
Jochen Schwenk et al.
doi:10.1038/nature08964
Abstract: http://links.ealert.nature.com/ctt?kn=258&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=258&m=34808103&r=MjA1NTkxMDA2MAS2&b=2&j=NzIzOTAyMTUS1&mt=1&rt=0

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Cord Blood America Interview Explains Diversified Revenues

manojhind2001us@gmail.com (Manoj Kumar Valluru) — Thu, 22 Apr 2010 11:01:40 PDT

Release #:812-77574-em-434148:

Cord Blood America Interview Explains Diversified Revenues

Cord Blood America's CEO Matthew Schissler, in Analyst Interview, Discusses Significantly Increasing Revenues

LAS VEGAS, April 21 /PRNewswire-FirstCall/ -- Cord Blood America, Inc. (OTC Bulletin Board: CBAI), the umbilical cord blood stem cell preservation company (http://www.cordblood-america.com ), is focused on bringing the life saving potential of stem cells, a biological insurance policy, to families nationwide and internationally. Its CEO and co-founder, Matthew Schissler, in an interview with analyst Francis Gaskins, said a focus this year is top-line revenue growth.

The announcement that the Cord Blood America is seeking to purchase controlling interest in a major, profitable South American stem cell company could increase revenue by $1.0 to $1.5 million in the next 12 month time period.
The purchase of a stem cell company in Germany, previously announced, could add up to $1 million in revenues also in the next 12 months.
The agreement to collect placentas for a world renowned tissue bank, announced this week, could add up to one million dollars in revenues annually and significantly diversifies the Company's revenue stream.
Cord Blood America recently visited China where its new facility, in partnership with a Chinese pharmaceutical company, will have storage facilities ten times the size of Cord Blood America's new Las Vegas laboratory, which is believed to be the largest of its kind in the U.S. Operations are scheduled to begin in 2011.

The entire interview is available at http://gaskinsco.com/cbai-4-20-10.mp3

About Cord Blood America

Cord Blood America (OTC Bulletin Board: CBAI) is the parent company of CorCell, which facilitates umbilical cord blood stem cell preservation for expectant parents and their children. Its mission is to be the most respected stem cell preservation company in the industry. Collected through a safe and non-invasive process, cord blood stem cells offer a powerful and potentially life-saving resource for treating a growing number of ailments, including cancer, leukemia, blood, and immune disorders. To find out more about Cord Blood America, Inc. (OTC Bulletin Board: CBAI), visit our website at www.corcell.com. For investor information, visit www.cordblood-america.com.

CONTACT:
Paul Knopick
E & E Communications
949/707-5365
pknopick@eandecommunications.com

SOURCE Cord Blood America, Inc.

My EANDE

More Information

Nature Immunology Contents: May 2010 Volume 11 pp 357 - 454

manojhind2001us@gmail.com (Manoj Kumar Valluru) — Thu, 22 Apr 2010 11:02:36 PDT

NATURE IMMUNOLOGY

May 2010 Volume 11 Number 5, pp 357 - 454

Visit Nature Immunology online to browse the journal.

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=====================================================================

----------------------
EDITORIAL
----------------------
Of faith and reason p357
doi:10.1038/ni0510-357
The openly religious stance of the NIH director could have
undesirable effects on science education in the United States.
http://links.ealert.nature.com/ctt?kn=24&m=34805966&r=MTc2NTA4MDAwNgS2&b=2&j=NzIzNzExMTMS1&mt=1&rt=0

----------------------
MEETING REPORT
----------------------
The 2010 Midwinter Conference of Immunologists at Asilomar
pp359 - 361
Stephen P Schoenberger, Hilde Cheroutre, Christel Uittenbogaart
and Ann Marshak-Rothstein
doi:10.1038/ni0510-359
A diverse group of immunologists gathered recently at Asilomar,
California, to discuss advances in the theory and practice of
their field. The pristine setting and informal atmosphere have
always made this a unique and memorable conference.
http://links.ealert.nature.com/ctt?kn=13&m=34805966&r=MTc2NTA4MDAwNgS2&b=2&j=NzIzNzExMTMS1&mt=1&rt=0

----------------------
NEWS AND VIEWS
----------------------
HIV-1 and pattern-recognition receptors: a marriage of convenience
pp363 - 365
Michel J Tremblay
doi:10.1038/ni0510-363
Dendritic cells can internalize and degrade invading pathogens in
phagosomes, yet some HIV-1 particles can evade this degradation
process and productively infect dendritic cells. New data show
that HIV-1 replication is triggered by signal-transduction events
through Toll-like receptor 8 and DC-SIGN.
http://links.ealert.nature.com/ctt?kn=14&m=34805966&r=MTc2NTA4MDAwNgS2&b=2&j=NzIzNzExMTMS1&mt=1&rt=0

Unfolding new roles for XBP1 in immunity pp365 - 367
Alex Engel and Gregory M Barton
doi:10.1038/ni0510-365
A critical aspect of innate immune function is the coordinated
regulation of inflammatory gene expression. Now an unexpected
discovery shows that certain signaling components of the unfolded
protein response are required for optimal gene induction by Toll-like
receptors.
http://links.ealert.nature.com/ctt?kn=15&m=34805966&r=MTc2NTA4MDAwNgS2&b=2&j=NzIzNzExMTMS1&mt=1&rt=0

AIMing 2 defend against intracellular pathogens pp367 - 369
Arthur M Krieg
doi:10.1038/ni0510-367
Intracellular pathogens face a diverse array of innate immune
receptors. New data show that a single receptor, AIM2, functions
to detect bacterial or viral DNA in the cytosol, inducing a
protective inflammasome response.
http://links.ealert.nature.com/ctt?kn=16&m=34805966&r=MTc2NTA4MDAwNgS2&b=2&j=NzIzNzExMTMS1&mt=1&rt=0

Another zinc finger in the pie of CD4-CD8 lineage choice
pp370 - 371
Kensuke Takada and Yousuke Takahama
doi:10.1038/ni0510-370
The 'choice' between the CD4+CD8- and CD4-CD8+ T cell lineage
involves genomic specification via a set of transcription factors.
A new study shows that the zinc-finger protein MAZR is another
member of this transcription factor network.
http://links.ealert.nature.com/ctt?kn=1&m=34805966&r=MTc2NTA4MDAwNgS2&b=2&j=NzIzNzExMTMS1&mt=1&rt=0

----------------------
RESEARCH HIGHLIGHTS
----------------------
Research Highlights p372
doi:10.1038/ni0510-372
http://links.ealert.nature.com/ctt?kn=3&m=34805966&r=MTc2NTA4MDAwNgS2&b=2&j=NzIzNzExMTMS1&mt=1&rt=0

----------------------
REVIEW
----------------------
The role of pattern-recognition receptors in innate immunity: update
on Toll-like receptors pp373 - 384
Taro Kawai and Shizuo Akira
doi:10.1038/ni.1863
Abstract: http://links.ealert.nature.com/ctt?kn=2&m=34805966&r=MTc2NTA4MDAwNgS2&b=2&j=NzIzNzExMTMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=5&m=34805966&r=MTc2NTA4MDAwNgS2&b=2&j=NzIzNzExMTMS1&mt=1&rt=0

----------------------
ARTICLES
----------------------
The AIM2 inflammasome is critical for innate immunity to Francisella
tularensis pp385 - 393
Teresa Fernandes-Alnemri et al.
doi:10.1038/ni.1859
The AIM2 inflammasome induces maturation of the proinflammatory
cytokines IL-1beta and IL-18. Using AIM2-deficient mice, Fitzgerald
and colleagues and Alnemri and colleagues show that the AIM2
inflammasome is essential for host defense against cytosolic
bacteria and DNA viruses.
Abstract: http://links.ealert.nature.com/ctt?kn=4&m=34805966&r=MTc2NTA4MDAwNgS2&b=2&j=NzIzNzExMTMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=7&m=34805966&r=MTc2NTA4MDAwNgS2&b=2&j=NzIzNzExMTMS1&mt=1&rt=0

The AIM2 inflammasome is essential for host defense against cytosolic
bacteria and DNA viruses pp395 - 402
Vijay A K Rathinam et al.
doi:10.1038/ni.1864
The AIM2 inflammasome induces maturation of the proinflammatory
cytokines IL-1beta and IL-18. Using AIM2-deficient mice, Fitzgerald
and colleagues and Alnemri and colleagues show that the AIM2
inflammasome is essential for host defense against cytosolic bacteria
and DNA viruses.
Abstract: http://links.ealert.nature.com/ctt?kn=6&m=34805966&r=MTc2NTA4MDAwNgS2&b=2&j=NzIzNzExMTMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=133&m=34805966&r=MTc2NTA4MDAwNgS2&b=2&j=NzIzNzExMTMS1&mt=1&rt=0

Influenza virus activates inflammasomes via its intracellular M2 ion
channel pp404 - 410
Takeshi Ichinohe, Iris K Pang and Akiko Iwasaki
doi:10.1038/ni.1861
The mechanism by which influenza virus activates the NLRP3
inflammasome is unknown. Iwasaki and colleagues show that the
influenza virus M2 protein, a proton-selective ion channel,
stimulates the NLRP3 inflammasome pathway.
Abstract: http://links.ealert.nature.com/ctt?kn=132&m=34805966&r=MTc2NTA4MDAwNgS2&b=2&j=NzIzNzExMTMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=131&m=34805966&r=MTc2NTA4MDAwNgS2&b=2&j=NzIzNzExMTMS1&mt=1&rt=0

TLR activation of the transcription factor XBP1 regulates innate
immune responses in macrophages pp411 - 418
Fabio Martinon, Xi Chen, Ann-Hwee Lee and Laurie H Glimcher
doi:10.1038/ni.1857
The transcription factor XBP1 is activated after endoplasmic
reticulum stress. Glimcher and colleagues show that XBP1 can
also be activated by TLR2 and TLR4 signaling pathways, in which
it sustains proinflammatory cytokine production.
Abstract: http://links.ealert.nature.com/ctt?kn=127&m=34805966&r=MTc2NTA4MDAwNgS2&b=2&j=NzIzNzExMTMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=128&m=34805966&r=MTc2NTA4MDAwNgS2&b=2&j=NzIzNzExMTMS1&mt=1&rt=0

HIV-1 exploits innate signaling by TLR8 and DC-SIGN for productive
infection of dendritic cells pp419 - 426
Sonja I Gringhuis et al.
doi:10.1038/ni.1858
HIV-1 replication requires proviral production of full-length
transcripts. Geijtenbeek and colleagues show that early
Tat-independent HIV-1 replication coopts innate receptor
signaling by DC-SIGN and TLR8 to promote RNA polymerase II
elongation complexes at long terminal repeats.
Abstract: http://links.ealert.nature.com/ctt?kn=124&m=34805966&r=MTc2NTA4MDAwNgS2&b=2&j=NzIzNzExMTMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=126&m=34805966&r=MTc2NTA4MDAwNgS2&b=2&j=NzIzNzExMTMS1&mt=1&rt=0

Capture of influenza by medullary dendritic cells via SIGN-R1 is
essential for humoral immunity in draining lymph nodes pp427 - 434
Santiago F Gonzalez et al.
doi:10.1038/ni.1856
Vaccines elicit neutralizing antibodies to protect organisms against
viral infection. Carroll and colleagues show that medullary lymph
node dendritic cells capture influenza virus via SIGN-R1 and are
necessary for humoral antiviral immunity.
Abstract: http://links.ealert.nature.com/ctt?kn=121&m=34805966&r=MTc2NTA4MDAwNgS2&b=2&j=NzIzNzExMTMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=122&m=34805966&r=MTc2NTA4MDAwNgS2&b=2&j=NzIzNzExMTMS1&mt=1&rt=0

The transcription factor c-Myb primes CD4+CD8+ immature thymocytes
for selection into the iNKT lineage pp435 - 441
Taishan Hu et al.
doi:10.1038/ni.1865
How double-positive thymocytes enter the invariant natural killer T
cell lineage is still unclear. Alberola-Ila and co-workers show that
c-Myb has a central role in this process.
Abstract: http://links.ealert.nature.com/ctt?kn=119&m=34805966&r=MTc2NTA4MDAwNgS2&b=2&j=NzIzNzExMTMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=120&m=34805966&r=MTc2NTA4MDAwNgS2&b=2&j=NzIzNzExMTMS1&mt=1&rt=0

The zinc-finger protein MAZR is part of the transcription factor
network that controls the CD4 versus CD8 lineage fate of
double-positive thymocytes pp442 - 448
Shinya Sakaguchi et al.
doi:10.1038/ni.1860
MAZR is an important negative regulator of CD8 expression. Ellmeier
and colleagues now demonstrate that MAZR directly regulates the
transcription factor Th-POK locus and is therefore involved in CD4
and CD8 cell-fate 'decisions'.
Abstract: http://links.ealert.nature.com/ctt?kn=112&m=34805966&r=MTc2NTA4MDAwNgS2&b=2&j=NzIzNzExMTMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=111&m=34805966&r=MTc2NTA4MDAwNgS2&b=2&j=NzIzNzExMTMS1&mt=1&rt=0

Production of an antigenic peptide by insulin-degrading enzyme
pp449 - 454
Nicolas Parmentier et al.
doi:10.1038/ni.1862
Most antigenic peptides presented by MHC class I are produced by the
proteasome. Van den Eynde and co-workers show that a MAGE-A3-derived
peptide is produced directly by the cytosolic metallopeptidase IDE.
Abstract: http://links.ealert.nature.com/ctt?kn=107&m=34805966&r=MTc2NTA4MDAwNgS2&b=2&j=NzIzNzExMTMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=109&m=34805966&r=MTc2NTA4MDAwNgS2&b=2&j=NzIzNzExMTMS1&mt=1&rt=0

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Cord Blood America Again Diversifies Revenue Stream

manojhind2001us@gmail.com (Manoj Kumar Valluru) — Thu, 22 Apr 2010 11:03:44 PDT

Release #:812-77533-em-434148:

Cord Blood America Again Diversifies Revenue Stream

Cord Blood America to Provide Placentas for Transplantation

LAS VEGAS, April 20 /PRNewswire-FirstCall/ -- Cord Blood America, Inc. (OTC Bulletin Board: CBAI), the umbilical cord blood stem cell preservation company (http://www.cordblood-america.com ) focused on bringing the life saving potential of stem cells, a biological insurance policy, to families nationwide and internationally, announced today that it has signed a Definitive Supplier Agreement with a well-respected, accredited, tissue bank providing placenta collection services for therapeutic transplantation, and Cord Blood America is already filling orders.

The placenta (sometimes called afterbirth) connects the developing fetus to the uterine wall and supplies the fetus with oxygen and food. It is normally discarded at birth. Recent research has shown that there are significant numbers of stem cells in the placenta and they can be safely extracted for transplantation.

These stem cells are currently used to cure chronic blood-related disorders such as sickle cell disease, thalassemia and leukemia, and research is ongoing on utilizing stem cells in treatments of a number of chronic medical conditions including diabetes, heart disease and stroke.

"CBAI has committed to diversify our revenue streams. This contract drives revenues to CBAI for supplying a different source of stem cells. It's the dawn of a new and exciting era for CBAI," said Matthew Schissler, Cord Blood America co-founder and CEO. Terms of the agreement were not disclosed. "Because of the sensitive nature of the project, and intellectual property rights involved, we can only provide a limited amount of detail. However, we wanted to let our shareholders know a different revenue stream has been consummated, one in which we have extreme enthusiasm."

About Cord Blood America

CONTACT:
Paul Knopick
E & E Communications
949/707-5365
pknopick@eandecommunications.com

SOURCE Cord Blood America, Inc.

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More Information

Cord Blood America Due Diligence Announcement

manojhind2001us@gmail.com (Manoj Kumar Valluru) — Thu, 22 Apr 2010 11:03:44 PDT

Release #:812-77487-em-434148:

Cord Blood America Due Diligence Announcement

Cord Blood America Signs Letter of Intent to Purchase Controlling Interest in BioCells, Inc., a Major, Profitable South American Company

BioCells, the second largest stem cell storage company in Argentina, is profitable, with annual revenues in 2009 of $1.2 million (USD), and 12 locations throughout that country, plus recent expansion into Uruguay and Paraguay. On February 8, 2010, Cord Blood America announced that BioCells finalized an agreement to process and store cord blood specimens with Cord Blood America in Las Vegas.

"The transaction is subject to the normal due diligence process," said Matthew Schissler, Cord Blood America co-founder and CEO. "We believe this potential transaction is an excellent example of how we are building Cord Blood America into the world's premier stem cell storage company. If successful in due diligence, this will give CBAI a majority stake in a proven South American company. Adding our recently announced acquisition in Europe and our Licensing Agreement in China, this step further proves our commitment to our mission, becoming the world's largest stem cell storage company and creating the cellular pharmacy business model which will be in high demand in years to come."

About Cord Blood America

Cord Blood America (OTC Bulletin Board:CBAI.ob - News) is the parent company of CorCell, which facilitates umbilical cord blood stem cell preservation for expectant parents and their children. Its mission is to be the most respected stem cell preservation company in the industry. Collected through a safe and non-invasive process, cord blood stem cells offer a powerful and potentially life-saving resource for treating a growing number of ailments, including cancer, leukemia, blood, and immune disorders. To find out more about Cord Blood America, Inc. (OTC Bulletin Board:CBAI.ob - News), visit our website at http://www.corcell.com/. For investor information, visit http://www.cordblood-america.com/.

CONTACT:
Paul Knopick
E & E Communications
949/707-5365
pknopick@eandecommunications.com

Forward-Looking Statements

Some statements made in this press release are forward-looking statements, which are made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. We use words such as "anticipate,'' "believe,'' "expect,'' "future,'' "intend,'' "plan,'' and similar expressions to identify forward-looking statements. These statements including those related to the growth of the industry, new stem cell treatments, and the Company's performance, are only predictions and are subject to certain risks, uncertainties and assumptions. Additional risks are identified and described in the Company's public filings with the Securities and Exchange Commission. Statements made herein are as of the date of this press release and should not be relied upon as of any subsequent date. The Company's past performance is not necessarily indicative of its future performance. The Company does not undertake, and the Company specifically disclaims any obligation to update any forward-looking statements to reflect occurrences, developments, events, or circumstances after the date of such statement

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More Information

Bone Marrow Transplantation - Table of Contents alert Volume 45 Issue 4

manojhind2001us@gmail.com (Manoj Kumar Valluru) — Wed, 07 Apr 2010 03:01:02 PDT

BONE MARROW TRANSPLANTATION

April 2010 Volume 45 Number 4, pp 613 - 806
---------------------------------------------------------------------
Announcing an open access option in Bone Marrow Transplantation.
http://links.ealert.nature.com/ctt?kn=186&m=34762562&r=MTc1NjE0NTQ4OQS2&b=2&j=NzA5ODA2NzYS1&mt=1&rt=0

An open access option is now available to all authors of original
research papers that are accepted for publication in Bone Marrow
Transplantation. Open articles will be freely accessible to all readers
immediately on publication.

Learn more about Open by visiting http://links.ealert.nature.com/ctt?kn=27&m=34762562&r=MTc1NjE0NTQ4OQS2&b=2&j=NzA5ODA2NzYS1&mt=1&rt=0

----------------------
ORIGINAL ARTICLES
----------------------
Multivariate analyses of immune reconstitution in children after
allo-SCT: risk-estimation based on age-matched leukocyte sub-populations
M Koenig, S Huenecke, E Salzmann-Manrique, R Esser, R Quaritsch,
D Steinhilber, H H Radeke, H Martin, P Bader, T Klingebiel,
D Schwabe, G Schneider, T Lehrnbecher, A Orth and U Koehl
Abstract: http://links.ealert.nature.com/ctt?kn=169&m=34762562&r=MTc1NjE0NTQ4OQS2&b=2&j=NzA5ODA2NzYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=172&m=34762562&r=MTc1NjE0NTQ4OQS2&b=2&j=NzA5ODA2NzYS1&mt=1&rt=0

Successful SCT for Nijmegen breakage syndrome
M H Albert, A R Gennery, J Greil, C M Cale, K Kalwak, I Kondratenko,
W Mlynarski, G Notheis, M Fuhrer, I Schmid and B H Belohradsky
Abstract: http://links.ealert.nature.com/ctt?kn=171&m=34762562&r=MTc1NjE0NTQ4OQS2&b=2&j=NzA5ODA2NzYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=184&m=34762562&r=MTc1NjE0NTQ4OQS2&b=2&j=NzA5ODA2NzYS1&mt=1&rt=0

Efficacy of a 3-day, low-dose treatment with 5-azacytidine followed by
donor lymphocyte infusions in older patients with acute myeloid leukemia
or chronic myelomonocytic leukemia relapsed after allografting
M Lubbert, H Bertz, R Wasch, R Marks, B Ruter, R Claus and J Finke
Abstract: http://links.ealert.nature.com/ctt?kn=167&m=34762562&r=MTc1NjE0NTQ4OQS2&b=2&j=NzA5ODA2NzYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=168&m=34762562&r=MTc1NjE0NTQ4OQS2&b=2&j=NzA5ODA2NzYS1&mt=1&rt=0

Impact of pretransplant comorbidities on alemtuzumab-based
reduced-intensity conditioning allogeneic hematopoietic SCT for patients with
high-risk myelodysplastic syndrome and AML
Z Y Lim, W Ingram, R Brand, A Ho, M Kenyon, S Devereux, J Marsh, G J Mufti and A Pagliuca
Abstract: http://links.ealert.nature.com/ctt?kn=194&m=34762562&r=MTc1NjE0NTQ4OQS2&b=2&j=NzA5ODA2NzYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=193&m=34762562&r=MTc1NjE0NTQ4OQS2&b=2&j=NzA5ODA2NzYS1&mt=1&rt=0

BU/melphalan and auto-SCT in AML patients in first CR: a 'Gruppo Italiano
Trapianto di Midollo Osseo (GITMO)' retrospective study
R M Lemoli, A D'Addio, G Marotta, L Pezzullo, E Zuffa, M Montanari,
A De Vivo, A Bonini, P Galieni, A M Carella, S Guidi, M Michieli,
A Olivieri and A Bosi
Abstract: http://links.ealert.nature.com/ctt?kn=192&m=34762562&r=MTc1NjE0NTQ4OQS2&b=2&j=NzA5ODA2NzYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=190&m=34762562&r=MTc1NjE0NTQ4OQS2&b=2&j=NzA5ODA2NzYS1&mt=1&rt=0

Utility of early versus late fiberoptic bronchoscopy in the evaluation
of new pulmonary infiltrates following hematopoietic stem cell transplantation
V R Shannon, B S Andersson, X Lei, R E Champlin and D P Kontoyiannis
Abstract: http://links.ealert.nature.com/ctt?kn=198&m=34762562&r=MTc1NjE0NTQ4OQS2&b=2&j=NzA5ODA2NzYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=197&m=34762562&r=MTc1NjE0NTQ4OQS2&b=2&j=NzA5ODA2NzYS1&mt=1&rt=0

Patient and family education in HSCT: improving awareness of respiratory
virus infection and influenza vaccination. A descriptive study and brief
intervention
P E Ferguson, C F C Jordens and N M Gilroy
Abstract: http://links.ealert.nature.com/ctt?kn=196&m=34762562&r=MTc1NjE0NTQ4OQS2&b=2&j=NzA5ODA2NzYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=195&m=34762562&r=MTc1NjE0NTQ4OQS2&b=2&j=NzA5ODA2NzYS1&mt=1&rt=0

Voriconazole provides effective prophylaxis for invasive fungal
infection in patients receiving glucocorticoid therapy for GVHD
U Gergis, K Markey, J Greene, M Kharfan-Dabaja, T Field, G Wetzstein,
M J Schell, Y Huang, C Anasetti and J Perkins
Abstract: http://links.ealert.nature.com/ctt?kn=189&m=34762562&r=MTc1NjE0NTQ4OQS2&b=2&j=NzA5ODA2NzYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=187&m=34762562&r=MTc1NjE0NTQ4OQS2&b=2&j=NzA5ODA2NzYS1&mt=1&rt=0

Donor CD4 T cells convert mixed to full donor T-cell chimerism and
replenish the CD52-positive T-cell pool after alemtuzumab-based
T-cell-depleted allo-transplantation
R G Meyer, E M Wagner, A Konur, K Bender, T Schmitt, J Hemmerling,
D Wehler, U F Hartwig, E Roosnek, C Huber, K Kolbe and W Herr
Abstract: http://links.ealert.nature.com/ctt?kn=188&m=34762562&r=MTc1NjE0NTQ4OQS2&b=2&j=NzA5ODA2NzYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=201&m=34762562&r=MTc1NjE0NTQ4OQS2&b=2&j=NzA5ODA2NzYS1&mt=1&rt=0

The impact of a change in antibacterial prophylaxis from ceftazidime
to levofloxacin in allogeneic hematopoietic cell transplantation
K A Guthrie, M Yong, D Frieze, L Corey and D N Fredricks
Abstract: http://links.ealert.nature.com/ctt?kn=200&m=34762562&r=MTc1NjE0NTQ4OQS2&b=2&j=NzA5ODA2NzYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=204&m=34762562&r=MTc1NjE0NTQ4OQS2&b=2&j=NzA5ODA2NzYS1&mt=1&rt=0

Sequential Organ Failure Assessment predicts the outcome of SCT
recipients admitted to intensive care unit
K Gilli, M Remberger, H Hjelmqvist, O Ringden and J Mattsson
Abstract: http://links.ealert.nature.com/ctt?kn=203&m=34762562&r=MTc1NjE0NTQ4OQS2&b=2&j=NzA5ODA2NzYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=206&m=34762562&r=MTc1NjE0NTQ4OQS2&b=2&j=NzA5ODA2NzYS1&mt=1&rt=0

Comparison of thrombotic microangiopathy after allogeneic hematopoietic
cell transplantation with high-dose or nonmyeloablative conditioning
E Willems, F Baron, L Seidel, P Frere, G Fillet and Y Beguin
Abstract: http://links.ealert.nature.com/ctt?kn=205&m=34762562&r=MTc1NjE0NTQ4OQS2&b=2&j=NzA5ODA2NzYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=207&m=34762562&r=MTc1NjE0NTQ4OQS2&b=2&j=NzA5ODA2NzYS1&mt=1&rt=0

Hepatocytes of donor origin in recipient liver after hematopoietic SCT
in [beta]-thalassemia major patients
M Mirzania, A Ghavamzadeh, M Yaghmaie, N Sedighi, N Kamalian,
K Alimoghaddam, S H Ghaffari, P Azimi and B Chahardouli
Abstract: http://links.ealert.nature.com/ctt?kn=185&m=34762562&r=MTc1NjE0NTQ4OQS2&b=2&j=NzA5ODA2NzYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=180&m=34762562&r=MTc1NjE0NTQ4OQS2&b=2&j=NzA5ODA2NzYS1&mt=1&rt=0

Transplantation-associated thrombotic microangiopathy: effect of concomitant
GVHD on efficacy of therapeutic plasma exchange
G A Kennedy, N Kearey, S Bleakley, J Butler, K Mudie and S Durrant
Abstract: http://links.ealert.nature.com/ctt?kn=178&m=34762562&r=MTc1NjE0NTQ4OQS2&b=2&j=NzA5ODA2NzYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=182&m=34762562&r=MTc1NjE0NTQ4OQS2&b=2&j=NzA5ODA2NzYS1&mt=1&rt=0

Taste disorders and oral evaluation in patients undergoing allogeneic
hematopoietic SCT
C C Boer, M E P Correa, E C M Miranda and C A de Souza
Abstract: http://links.ealert.nature.com/ctt?kn=181&m=34762562&r=MTc1NjE0NTQ4OQS2&b=2&j=NzA5ODA2NzYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=163&m=34762562&r=MTc1NjE0NTQ4OQS2&b=2&j=NzA5ODA2NzYS1&mt=1&rt=0

Absence of IL-23p19 in donor allogeneic cells reduces mortality from
acute GVHD
J S Thompson, Y Chu, J F Glass and S A Brown
Abstract: http://links.ealert.nature.com/ctt?kn=164&m=34762562&r=MTc1NjE0NTQ4OQS2&b=2&j=NzA5ODA2NzYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=165&m=34762562&r=MTc1NjE0NTQ4OQS2&b=2&j=NzA5ODA2NzYS1&mt=1&rt=0

IL-21 is critical for GVHD in a mouse model
A Meguro, K Ozaki, I Oh, K Hatanaka, H Matsu, R Tatara, K Sato,
W J Leonard and K Ozawa
Abstract: http://links.ealert.nature.com/ctt?kn=166&m=34762562&r=MTc1NjE0NTQ4OQS2&b=2&j=NzA5ODA2NzYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=162&m=34762562&r=MTc1NjE0NTQ4OQS2&b=2&j=NzA5ODA2NzYS1&mt=1&rt=0

Early thrombin generation and impaired fibrinolysis after SCT
associate with acute GVHD
A Pinomaki, L Volin, L Joutsi-Korhonen, J O Virtanen, M Lemponen,
T Ruutu and R Lassila
Abstract: http://links.ealert.nature.com/ctt?kn=129&m=34762562&r=MTc1NjE0NTQ4OQS2&b=2&j=NzA5ODA2NzYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=130&m=34762562&r=MTc1NjE0NTQ4OQS2&b=2&j=NzA5ODA2NzYS1&mt=1&rt=0

Suboptimal long-term physical performance in children and young adults
after pediatric allo-SCT
L Hovi, M Kurimo, M Taskinen, J Vettenranta, K Vettenranta and
U M Saarinen-Pihkala
Abstract: http://links.ealert.nature.com/ctt?kn=133&m=34762562&r=MTc1NjE0NTQ4OQS2&b=2&j=NzA5ODA2NzYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=134&m=34762562&r=MTc1NjE0NTQ4OQS2&b=2&j=NzA5ODA2NzYS1&mt=1&rt=0

The quality of life of adult survivors of childhood hematopoietic cell
transplant
J E Sanders, P A Hoffmeister, B E Storer, F R Appelbaum, R F Storb
and K L Syrjala
Abstract: http://links.ealert.nature.com/ctt?kn=131&m=34762562&r=MTc1NjE0NTQ4OQS2&b=2&j=NzA5ODA2NzYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=132&m=34762562&r=MTc1NjE0NTQ4OQS2&b=2&j=NzA5ODA2NzYS1&mt=1&rt=0

Functional performance status of hematopoietic SCT recipients in the
sub-acute phase of recovery
G S Morris, K E Brueilly, J S Scheetz and E A Brannan
Abstract: http://links.ealert.nature.com/ctt?kn=128&m=34762562&r=MTc1NjE0NTQ4OQS2&b=2&j=NzA5ODA2NzYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=127&m=34762562&r=MTc1NjE0NTQ4OQS2&b=2&j=NzA5ODA2NzYS1&mt=1&rt=0

Determinants of functional performance in long-term survivors of allogeneic
hematopoietic stem cell transplantation with chronic graft-versus-host
disease (cGVHD)
S A Mitchell, N Kline Leidy, K H Mooney, W N Dudley, S L Beck,
P C LaStayo, E W Cowen, P Palit, L E Comis, M C Krumlauf, D N Avila,
N Atlam, D H Fowler and S Z Pavletic
Abstract: http://links.ealert.nature.com/ctt?kn=126&m=34762562&r=MTc1NjE0NTQ4OQS2&b=2&j=NzA5ODA2NzYS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=125&m=34762562&r=MTc1NjE0NTQ4OQS2&b=2&j=NzA5ODA2NzYS1&mt=1&rt=0

----------------------
LETTERS TO THE EDITOR
----------------------
Adopting autologous hematopoietic stem cells with non-functional CCR5
and CXCR4 against HIV
Y Lai
http://links.ealert.nature.com/ctt?kn=141&m=34762562&r=MTc1NjE0NTQ4OQS2&b=2&j=NzA5ODA2NzYS1&mt=1&rt=0

Self-limited hemolysis due to anti-D passenger lymphocyte syndrome in
allogeneic hematopoietic stem cell transplantation
B R Adams, A N Miller and L J Costa
http://links.ealert.nature.com/ctt?kn=142&m=34762562&r=MTc1NjE0NTQ4OQS2&b=2&j=NzA5ODA2NzYS1&mt=1&rt=0

Glutathione S-transferase T1 is a potential new target for the hepatic
component of graft vs host disease after HSCT
I Aguilera, I Espigado, M J Martinez-Bravo, I Tallon, A Urbano-Ispizua
and A Nunez-Roldan
http://links.ealert.nature.com/ctt?kn=143&m=34762562&r=MTc1NjE0NTQ4OQS2&b=2&j=NzA5ODA2NzYS1&mt=1&rt=0

Herpes simplex virus encephalitis after allogeneic transplantation: an
instructive case
R Romee, C G Brunstein, D J Weisdorf and N S Majhail
http://links.ealert.nature.com/ctt?kn=144&m=34762562&r=MTc1NjE0NTQ4OQS2&b=2&j=NzA5ODA2NzYS1&mt=1&rt=0

Posterior reversible encephalopathy syndrome as a consequence of high dose
steroid administration after autologous PBSCT
S Sukumaran, B George, H P Nair and W R Drobyski
http://links.ealert.nature.com/ctt?kn=145&m=34762562&r=MTc1NjE0NTQ4OQS2&b=2&j=NzA5ODA2NzYS1&mt=1&rt=0

Target blood concentrations of CYA and tacrolimus in randomized controlled
trials for the prevention of acute GVHD after hematopoietic SCT
K Oshima, M Sato, K Terasako, S Kimura, S Okuda, S Kako and Y Kanda
http://links.ealert.nature.com/ctt?kn=146&m=34762562&r=MTc1NjE0NTQ4OQS2&b=2&j=NzA5ODA2NzYS1&mt=1&rt=0

Successful treatment of sinusoidal obstructive syndrome after hematopoietic
stem cell transplantation with recombinant human soluble thrombomodulin
T Ikezoe, K Togitani, N Komatsu, M Isaka and A Yokoyama
http://links.ealert.nature.com/ctt?kn=147&m=34762562&r=MTc1NjE0NTQ4OQS2&b=2&j=NzA5ODA2NzYS1&mt=1&rt=0

Prophylaxis with mycophenolate mofetil and CsA can decrease the incidence
of severe acute GVHD after antithymocyte globulin-based reduced-intensity
preparative regimen and allo-SCT from HLA-matched unrelated donors
E Brissot, P Chevallier, T Guillaume, J Delaunay, S Ayari, V Dubruille,
S Le Gouill, B Mahe, T Gastinne, N Blin, B Saulquin, P Moreau,
J-L Harousseau and M Mohty
http://links.ealert.nature.com/ctt?kn=138&m=34762562&r=MTc1NjE0NTQ4OQS2&b=2&j=NzA5ODA2NzYS1&mt=1&rt=0

Diffuse alveolar hemorrhage after unrelated cord blood transplantation
M Uchiyama and T Ikeda
http://links.ealert.nature.com/ctt?kn=137&m=34762562&r=MTc1NjE0NTQ4OQS2&b=2&j=NzA5ODA2NzYS1&mt=1&rt=0

Efficacy of lenalidomide in an sAML patient with del 5q relapsing after
reduced-intensity allogeneic stem cell transplantation performed in
complete remission
L Ades, V Eclache, C Gardin, S Boehrer, G Leroux, P Martiat and P Fenaux
http://links.ealert.nature.com/ctt?kn=139&m=34762562&r=MTc1NjE0NTQ4OQS2&b=2&j=NzA5ODA2NzYS1&mt=1&rt=0

Long-term remission after CD34+-selected PBSCT in a patient with advanced
intra-abdominal desmoplastic small round-cell tumor
L Houet, I Moller, M Engelhardt, G Kohler, H Schmidt, D Herchenbach,
M Schnitzler, A Schmitt-Graeff, A A Jungbluth, R Mertelsmann, B Rumstadt
and C F Waller
http://links.ealert.nature.com/ctt?kn=112&m=34762562&r=MTc1NjE0NTQ4OQS2&b=2&j=NzA5ODA2NzYS1&mt=1&rt=0

Successful allogeneic bone marrow transplantation for chronic myelomonocytic
leukemia complicated by refractory aortitis
M Mori, K Togami, H Fujita, D Inoue, T Kimura, S Shimoji, Y Nagai,
S Tabata, M Kurata, K Ito, H Hashimoto, A Matsushita, K Nagai, S Kaji and
T Takahashi
http://links.ealert.nature.com/ctt?kn=113&m=34762562&r=MTc1NjE0NTQ4OQS2&b=2&j=NzA5ODA2NzYS1&mt=1&rt=0

Molecular remission after allo-SCT in a patient with post-essential thrombocythemia
myelofibrosis carrying the MPL (W515A) mutation
E Rumi, F Passamonti, L Arcaini, P Bernasconi, C Elena, D Pietra, A Brisci,
E Arbustini, M Cazzola and M Lazzarino
http://links.ealert.nature.com/ctt?kn=110&m=34762562&r=MTc1NjE0NTQ4OQS2&b=2&j=NzA5ODA2NzYS1&mt=1&rt=0

Excessive toxicity of once daily i.v. BU, melphalan and thiotepa followed
by auto SCT on patients with non-Hodgkin's lymphoma
S-C Lee, S J Kim, D H Lee, W S Kim, C Suh and J-H Won
http://links.ealert.nature.com/ctt?kn=111&m=34762562&r=MTc1NjE0NTQ4OQS2&b=2&j=NzA5ODA2NzYS1&mt=1&rt=0

Successful treatment of transplantation-associated thrombotic microangiopathy
with recombinant human soluble thrombomodulin
M Sakai, T Ikezoe, K Bandobashi, K Togitani and A Yokoyama
http://links.ealert.nature.com/ctt?kn=108&m=34762562&r=MTc1NjE0NTQ4OQS2&b=2&j=NzA5ODA2NzYS1&mt=1&rt=0

----------------------
CORRIGENDUM
----------------------
Regionally limited or rare infections: prevention after hematopoietic
cell transplantation
J Gea-Banacloche, H Masur, C Arns da Cunha, T Chiller, L V Kirchhoff, P Shaw,
M Tomblyn and C Cordonnier
http://links.ealert.nature.com/ctt?kn=109&m=34762562&r=MTc1NjE0NTQ4OQS2&b=2&j=NzA5ODA2NzYS1&mt=1&rt=0

---------------------------------------------------------------------
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Latest PhD Studentships - 6 April 2010

manojhind2001us@gmail.com (Manoj Kumar Valluru) — Wed, 07 Apr 2010 03:01:28 PDT

Welcome to the FindAPhD weekly Newsletter. Listed below are the latest research projects to be advertised on FindAPhD.com.

University of Edinburgh
PhD Studentship in Natural Language Processing at the School of Informatics, University of Edinburgh

University of Edinburgh
Peatland responses to fire: the consequences to vegetation and greenhouse gas balance

Cardiff University
Acid-catalysed intramolecular hydroaminations

University of Birmingham
The emplacement and petrogenesis of the late Caledonian Newry Igneous Complex, N. Ireland: Implications for the sructure and timing of a post subduction granite complex

University of Birmingham
Gaze-centric multimodal interaction in interactive 3D serious games

University of York
Developing new applications for nanoparticles in biological imaging

SINAPSE
Development of new molecular tracers as tools for imaging neurological disease

SINAPSE
Developing improved co-registration tools for EEG and ERP research; enhancementtools for topographic mapping.

SINAPSE
INTERACT: Medical imaging accessibility project

SINAPSE
Fluid dynamics assessment of spiral flow inducing intravascular stents.

SINAPSE
Image guidance for in situ ablation cryotherapy treatment for cancer

University of Worcester
An Ecocritical Study of the Poetry of Edward Thomas and Robert Frost

King's College London
Dietary phytonutrients and vascular cell function

The School of Pharmacy, University of London
Proteomics and molecular genetics of glycine receptor interacting proteins in startle disease/hyperekplexia

SINAPSE
Development of new molecular tracers as tools for imaging neurological disease

Many more projects have been added this week! Click here to view them all!

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Cord Blood America Sponsoring Stem Cell Golf Tournament

manojhind2001us@gmail.com (Manoj Kumar Valluru) — Wed, 07 Apr 2010 03:01:28 PDT

Release #:812-76967-em-434148:

Cord Blood America Sponsoring Stem Cell Golf Tournament

Cord Blood America Sponsoring Golf Classic to Advance Stem Cell Research

-- Treating Stroke, Parkinson's, Alzheimer's --

LAS VEGAS, April 5 /PRNewswire-FirstCall/ -- Cord Blood America, Inc. (OTC Bulletin Board: CBAI), the umbilical cord blood stem cell preservation company (http://www.cordblood-america.com ) focused on bringing the life saving potential of stem cells, a biological insurance policy, to families nationwide and internationally, announced today that it is a sponsor of the 2010 Brodie Golf Classic Charity Invitational on April 19th at La Quinta County Club, California.

"John Brodie was a well known, successful quarterback with the NFL's San Francisco 49ers, a Senior PGA golf professional and an NBC broadcaster. He suffered a massive stroke in 2000. Adult stem cell treatments have dramatically improved his ability to walk and speak again. The golf classic he sponsors contributes 100 percent of the net proceeds to the New York Stem Cell Foundation, an organization dedicated to furthering the research of Stem Cell therapies in treating stroke, Parkinson's disease, Alzheimer's and spinal cord injury. This is exactly the kind of charitable giving that Cord Blood America, as a major national and international stem cell storage company, is proud to be involved in," said Matthew Schissler, Cord Blood America co-founder and CEO.

Information about the charity classic is available at http://www.brodiegolfclassic.org, which also features an educational write-up about stem cell research. "We are pleased to be a sponsor of this event and we want to do all that we can to increase research into the numerous potential uses of stem cells to treat diseases which, up until now, have no cure and even very few effective treatments," Mr. Schissler said.

About Cord Blood America

About The New York Stem Cell Foundation

Founded in 2005, The New York Stem Cell Foundation is dedicated to furthering stem cell research to advance the search for cures of the major diseases of our time. NYSCF opened the first privately funded stem cell laboratory in New York City in March 2006 to serve as a "safe haven" where scientists can conduct advanced stem cell research free of federal restrictions. The organization supports scientists engaged in stem cell research through grants, fellowships and symposia; runs collaborative, state-of-the-art research facilities directly focused on curing disease; and educates the public about the importance and potential benefits of stem cell research. For more information, visit www.nyscf.org.

CONTACT:
Paul Knopick
E & E Communications
949/707-5365
pknopick@eandecommunications.com

SOURCE Cord Blood America, Inc.

Media Contact: Paul Knopick of E & E Communications, +1-949-707-5365, pknopick@eandecommunications.com, for Cord Blood America, Inc.

Web Site: http://www.cordblood-america.com

My EANDE

More Information

ScienceDirect Alert: Cell, Vol. 141, Iss. 1, 2010

manojhind2001us@gmail.com (Manoj Kumar Valluru) — Wed, 07 Apr 2010 03:02:31 PDT

New Volume/Issue is now available on ScienceDirect

Cell

Volume 141, Issue 1, Pages 1-192 (2 April 2010)

Leading Edge

In This Issue
Pages 1, 3

Microbiology Select
Pages 5, 7

Essay

It's Diagnostics, Stupid
Pages 13-17
René Bernards

Previews

Drugging Drug Resistance
Pages 18-20
Jan-Hermen Dannenberg, Anton Berns

Exposing p120 Catenin's Most Intimate Affair
Pages 20-22
Albert B. Reynolds

Optogenetics 3.0
Pages 22-24
Xu Liu, Susumu Tonegawa

Time for Bacteria to Slow down
Pages 24-26
Judith P. Armitage, Richard M. Berry

Reviews

Origin of Chromosomal Translocations in Lymphoid Cancer
Pages 27-38
André Nussenzweig, Michel C. Nussenzweig

Macrophage Diversity Enhances Tumor Progression and Metastasis
Pages 39-51
Bin-Zhi Qian, Jeffrey W. Pollard

10.

Matrix Metalloproteinases: Regulators of the Tumor Microenvironment
Pages 52-67
Kai Kessenbrock, Vicki Plaks, Zena Werb

Articles

11.

A Chromatin-Mediated Reversible Drug-Tolerant State in Cancer Cell Subpopulations
Pages 69-80
Sreenath V. Sharma, Diana Y. Lee, Bihua Li, Margaret P. Quinlan, Fumiyuki Takahashi, Shyamala Maheswaran, Ultan McDermott, Nancy Azizian, Lee Zou, Michael A. Fischbach, Kwok-Kin Wong, Kathleyn Brandstetter, Ben Wittner, Sridhar Ramaswamy, Marie Classon, Jeff Settleman

Graphical Abstract

► Human cancer cell lines harbor a subpopulation of “drug-tolerant” cells ► The drug-tolerant state can emerge de novo and is transiently maintained ► The emergence of drug tolerance requires IGF-1R signaling ► Drug tolerance involves distinct chromatin states that can be disrupted

12.

Persistent Telomere Damage Induces Bypass of Mitosis and Tetraploidy
Pages 81-93
Teresa Davoli, Eros Lazzerini Denchi, Titia de Lange

Graphical Abstract

► Dysfunctional telomeres can elicit a persistent DNA damage signal ► Persistent DNA damage signaling causes endoreduplication in p53-deficient cells ► Bypass of mitosis, geminin degradation, and Cdt1 re-expression allow a 2^nd S phase ► Tetraploidy resulting from this pathway may lead to cancer-associated aneuploidy

13.

Recombination Proteins Mediate Meiotic Spatial Chromosome Organization and Pairing
Pages 94-106
Aurora Storlazzi, Silvana Gargano, Gwenael Ruprich-Robert, Matthieu Falque, Michelle David, Nancy Kleckner, Denise Zickler

Graphical Abstract

► Recombination proteins Mer3, Msh4, and Mlh1 play an early role in meiotic pairing ► Msh4 determines alignment spacing of homologous chromosomes ► Homolog pairing involves precrossover interference and entanglement avoidance ► Mlh1p is required for postalignment resolution of interlocks

14.

Second Messenger-Mediated Adjustment of Bacterial Swimming Velocity
Pages 107-116
Alex Boehm, Matthias Kaiser, Hui Li, Christian Spangler, Christoph Alexander Kasper, Martin Ackermann, Volkhard Kaever, Victor Sourjik, Volker Roth, Urs Jenal

Graphical Abstract

► Concentration of second messenger cyclic di-GMP sets bacterial swimming velocity ► Upon cyclic di-GMP binding, YcgR interacts with the flagellar motor protein MotA ► YcgR binding to MotA acts to curb motor output in a brake-like fashion ► Pathway activation and resulting deceleration coincide with nutrient depletion

15.

Dynamic and Static Interactions between p120 Catenin and E-Cadherin Regulate the Stability of Cell-Cell Adhesion
Pages 117-128
Noboru Ishiyama, Seung-Hye Lee, Shuang Liu, Guang-Yao Li, Matthew J. Smith, Louis F. Reichardt, Mitsuhiko Ikura

Graphical Abstract

► Crystal structure of p120 in complex with E-cadherin juxtamembrane domain ► Mutations in p120 confirm functional importance of its interface with cadherins ► Static p120 and E-cadherin interface is critical for high affinity interaction ► NMR reveals dynamic interactions that regulate the stability of cell-cell adhesion

Resources

16.

Transcriptome-wide Identification of RNA-Binding Protein and MicroRNA Target Sites by PAR-CLIP
Pages 129-141
Markus Hafner, Markus Landthaler, Lukas Burger, Mohsen Khorshid, Jean Hausser, Philipp Berninger, Andrea Rothballer, Manuel Ascano Jr., Anna-Carina Jungkamp, Mathias Munschauer, Alexander Ulrich, Greg S. Wardle, Scott Dewell, Mihaela Zavolan, Thomas Tuschl

Graphical Abstract

► PAR-CLIP is a transcriptome-wide crosslinking method for RNA-binding proteins (RBP) ► It is based on incorporation of photoactivatable nucleoside analogs into nascent RNA ► Characteristic sequence transitions in the prepared cDNA reveal the precise binding site ► We deduced binding motifs and preferences for 5 different RBP families

17.

A Global In Vivo Drosophila RNAi Screen Identifies NOT3 as a Conserved Regulator of Heart Function
Pages 142-153
G. Gregory Neely, Keiji Kuba, Anthony Cammarato, Kazuya Isobe, Sabine Amann, Liyong Zhang, Mitsushige Murata, Lisa Elmén, Vaijayanti Gupta, Suchir Arora, Rinku Sarangi, Debasis Dan, Susumu Fujisawa, Takako Usami, Cui-ping Xia, Alex C. Keene, Nakissa N. Alayari, Hiroyuki Yamakawa, Ulrich Elling, Christian Berger, Maria Novatchkova, Rubina Koglgruber, Keiichi Fukuda, Hiroshi Nishina, Mitsuaki Isobe, J. Andrew Pospisilik, Yumiko Imai, Arne Pfeufer, Andrew A. Hicks, Peter P. Pramstaller, Sai Subramaniam, Akinori Kimura, Karen Ocorr, Rolf Bodmer, Josef M. Penninger

Graphical Abstract

► Whole-genome RNAi screen for heart genes in Drosophila yields many candidates ► Informatics analysis identifies heart genetic pathways in flies, mice, and humans ► The CCR4-Not complex is required for normal heart function in flies and mice ► Humans with NOT3 SNPs have altered heart QT interval, a risk factor for sudden death

18.

Molecular and Cellular Approaches for Diversifying and Extending Optogenetics
Pages 154-165
Viviana Gradinaru, Feng Zhang, Charu Ramakrishnan, Joanna Mattis, Rohit Prakash, Ilka Diester, Inbal Goshen, Kimberly R. Thompson, Karl Deisseroth

Graphical Abstract

► Molecular trafficking techniques open up new dimensions in mammalian optogenetics ► Manyfold-enhanced halorhodopsin eNpHR3.0 enables optical control with far-red light ► Trafficking-enhanced tools identified from genome mining expand spectral coverage ► Transcellular trafficking enables promoter-independent optical targeting by topology

Matters Arising and Response

19.

PlGF Blockade Does Not Inhibit Angiogenesis during Primary Tumor Growth
Pages 166-177
Carlos Bais, Xiumin Wu, Jenny Yao, Suya Yang, Yongping Crawford, Krista McCutcheon, Christine Tan, Ganesh Kolumam, Jean-Michel Vernes, Jeffrey Eastham-Anderson, Peter Haughney, Marcin Kowanetz, Thijs Hagenbeek, Ian Kasman, Hani Bou Reslan, Jed Ross, Nick Van Bruggen, Richard A.D. Carano, Yu-Ju Gloria Meng, Jo-Anne Hongo, Jean- Philippe Stephan, Masabumi Shibuya, Napoleone Ferrara

Graphical Abstract

► PlGF neutralization with monoclonal antibodies does not decrease tumor angiogenesis ► Inhibition of PlGF or VEGFR-1 signaling does not reduce growth of primary tumors ► Blocking PlGF signaling does not augment the efficacy of anti-VEGF-A treatment

20.

Further Pharmacological and Genetic Evidence for the Efficacy of PlGF Inhibition in Cancer and Eye Disease
Pages 178-190
Sara Van de Veire, Ingeborg Stalmans, Femke Heindryckx, Hajimu Oura, Annemilaï Tijeras-Raballand, Thomas Schmidt, Sonja Loges, Imke Albrecht, Bart Jonckx, Stefan Vinckier, Christophe Van Steenkiste, Sònia Tugues, Charlotte Rolny, Maria De Mol, Daniela Dettori, Patricia Hainaud, Lieve Coenegrachts, Jean-Olivier Contreres, Tine Van Bergen, Henar Cuervo, Wei-Hong Xiao, Carole Le Henaff, Ian Buysschaert, Behzad Kharabi Masouleh, Anja Geerts, Tibor Schomber, Philippe Bonnin, Vincent Lambert, Jurgen Haustraete, Serena Zacchigna, Jean-Marie Rakic, Wladimiro Jiménez, Agnes Noël, Mauro Giacca, Isabelle Colle, Jean-Michel Foidart, Gerard Tobelem, Manuel Morales-Ruiz, José Vilar, Patrick Maxwell, Stanley A. Vinores, Geert Carmeliet, Mieke Dewerchin, Lena Claesson-Welsh, Evelyne Dupuy, Hans Van Vlierberghe, Gerhard Christofori, Massimiliano Mazzone, Michael Detmar, Désiré Collen, Peter Carmeliet

Graphical Abstract

► PlGF inhibition phenocopies genetic deficiency in tumor models and ocular angiogenesis ► PlGF inhibition blocks vessel abnormalization rather than density in certain tumors ► Anti-mouse and anti-human PlGF antibodies are specific and efficacious ► Anti-PlGF treatment lacks efficacy in some cancer models

Erratum

21.

Norrin, Frizzled-4, and Lrp5 Signaling in Endothelial Cells Controls a Genetic Program for Retinal Vascularization
Page 191
Xin Ye, Yanshu Wang, Hugh Cahill, Minzhong Yu, Tudor C. Badea, Philip M. Smallwood, Neal S. Peachey, Jeremy Nathans

Snapshot

22.

SnapShot: DNA Polymerases I Prokaryotes
Pages 192-192.e1
James J. Foti, Graham C. Walker

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ScienceDirect Alert: Cell Stem Cell, Vol. 6, Iss. 4, 2010

manojhind2001us@gmail.com (Manoj Kumar Valluru) — Wed, 07 Apr 2010 03:03:11 PDT

New Volume/Issue is now available on ScienceDirect

Cell Stem Cell

Volume 6, Issue 4, Pages 287-396 (2 April 2010)

Editors' Notes
Page xi

Previews

Cell Competition: Pirates on the Tangled Bank
Pages 287-288
Douglas R. Green

Visualizing Blood Cell Emergence from Aortic Endothelium
Pages 289-290
Gemma Swiers, Nancy A. Speck, Marella F.T.R. de Bruijn

Hooking Up with Oct4
Pages 291-292
Ihor R. Lemischka

The Hair Follicle Bulge Stem Cell Niche Resists Transformation by the Hedgehog Pathway
Pages 292-294
Todd W. Ridky, Paul A. Khavari

MicroRNA-9 Controls a Migratory Mechanism in Human Neural Progenitor Cells
Pages 294-296
Nobuko Uchida

Cycling toward Elimination of Leukemic Stem Cells
Pages 296-297
Daniel Goff, Catriona Jamieson

Letters

“The Immortal DNA Strand”: Difficult to Digest?
Pages 298-299
Catherine Legraverend, Marion Escobar, Philippe Jay

Response to Legraverend et al.
Page 299
Inke Näthke

Perspective

10.

Deconstructing Pancreas Development to Reconstruct Human Islets from Pluripotent Stem Cells
Pages 300-308
Kristen D. McKnight, Pei Wang, Seung K. Kim

Articles

11.

p53-Mediated Hematopoietic Stem and Progenitor Cell Competition
Pages 309-322
Tanya Bondar, Ruslan Medzhitov

Graphical Abstract

► Irradiation induces competition specifically among stem and progenitor cells ► It depends on the relative, rather than absolute, levels of p53 activity ► Selection of the least damaged cells occurs over the course of months ► Outcompeted cells display markers of senescence and decreased proliferation

12.

MicroRNA-9 Coordinates Proliferation and Migration of Human Embryonic Stem Cell-Derived Neural Progenitors
Pages 323-335
Celine Delaloy, Lei Liu, Jin-A Lee, Hua Su, Fanxia Shen, Guo-Yuan Yang, William L. Young, Kathy N. Ivey, Fen-Biao Gao

Graphical Abstract

► miR-9 is expressed in hESC-derived early hNPCs and their progeny ► Loss of miR-9 inhibits early hNPC proliferation and delays maturation ► miR-9 knockdown promotes hNPC migration in vitro and in vivo ► Stathmin is a target of miR-9 and mediates its effects in early hNPCs

13.

Efficient Derivation of Functional Floor Plate Tissue from Human Embryonic Stem Cells
Pages 336-347
Christopher A. Fasano, Stuart M. Chambers, Gabsang Lee, Mark J. Tomishima, Lorenz Studer

Graphical Abstract

► Floor plate (FP) cells can be derived from human embryonic stem cells ► Derivation of FP cells is dependent on an early exposure to high levels of Sonic Hedgehog ► The FP generated defaults to an anterior positional identity ► FP is shifted towards posterior identity in response to Wnt and other caudalizing signals

14.

HOW Is Required for Stem Cell Maintenance in the Drosophila Testis and for the Onset of Transit-Amplifying Divisions
Pages 348-360
Adrian C. Monk, Nicole A. Siddall, Talila Volk, Barbara Fraser, Leonie M. Quinn, Eileen A. McLaughlin, Gary R. Hime

Graphical Abstract

► HOW is required for spermatogonial cell cycle progression ► HOW binds to bam mRNA and represses Bam accumulation ► How regulates spermatogonial cell cycle length ► Ectopic HOW delays differentiation of mitotic spermatogonia

Short Article

15.

Distinguishing Mast Cell and Granulocyte Differentiation at the Single-Cell Level
Pages 361-368
Christopher B. Franco, Ching-Cheng Chen, Micha Drukker, Irving L. Weissman, Stephen J. Galli

Graphical Abstract

► Single-cell analysis resolves hematopoietic progenitor lineage potential ► Distinct Sca-1^lo common myeloid and granulocyte/macrophage progenitors ► The mast cell lineage is independent from granulocyte differentiation ► Mast cell and megakaryocyte/erythrocyte lineages may be closely related

Resource

16.

An Oct4-Centered Protein Interaction Network in Embryonic Stem Cells
Pages 369-381
Debbie L.C. van den Berg, Tim Snoek, Nick P. Mullin, Adam Yates, Karel Bezstarosti, Jeroen Demmers, Ian Chambers, Raymond A. Poot

Graphical Abstract

► An improved affinity method identified an Oct4 interactome of >160 proteins ► Iterative purification with Oct4 interactors helped define the network ► Network shows links to the basal transcription machinery and signaling pathways ► Transcription factor interactions may facilitate recruitment to the genome

17.

An Expanded Oct4 Interaction Network: Implications for Stem Cell Biology, Development, and Disease
Pages 382-395
Mercedes Pardo, Benjamin Lang, Lu Yu, Haydn Prosser, Allan Bradley, M. Madan Babu, Jyoti Choudhary

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Publication Alert - Stem Cells - March 2010

manojhind2001us@gmail.com (Manoj Kumar Valluru) — Wed, 07 Apr 2010 03:03:12 PDT

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Stem Cells

Published on behalf of

AlphaMed Press

This Publication Alert is being sent to individuals who requested receipt of this information. For additional details, see the bottom of this message.

Current Issue

STEM CELLS
Volume 28, Issue 3, 2010.

Online ISSN: 1549-4918
Print ISSN: 1066-5099

Copyright © 2010 AlphaMed Press.

Research Articles

Pages 387-389
Law, Ethics, Religion, and Clinical Translation in the 21st Century - A Discussion with Derek Hei
Susan Rainey Daher, Majlinda Lako, Alan O. Trounson
Published Online: 17 Feb 2010
DOI 10.1002/stem.323

Pages 390-398
Identification of Vitronectin as an Extrinsic Inducer of Cancer Stem Cell Differentiation and Tumor Formation
Elaine M. Hurt, King Chan, Maria Ana Duhagon Serrat, Suneetha B. Thomas, Timothy D. Veenstra, William L. Farrar
Published Online: 8 Dec 2009
DOI 10.1002/stem.271

Pages 399-406
Neurons Generated from APP/APLP1/APLP2 Triple Knockout Embryonic Stem Cells Behave Normally in Vitro and in Vivo: Lack of Evidence for a Cell Autonomous Role of the Amyloid Precursor Protein in Neuronal Differentiation
Bruno A. Bergmans, S. Ali M. Shariati, Ron L.P. Habets, Patrik Verstreken, Luc Schoonjans, Ulrike Müller, Carlos G. Dotti, Bart De Strooper
Published Online: 4 Jan 2010
DOI 10.1002/stem.296

Pages 407-418
Hypoxia Promotes Efficient Differentiation of Human Embryonic Stem Cells to Functional Endothelium
Sonia Prado-Lopez, Ana Conesa, Ana Armiñán, Magdalena Martínez-Losa, Carmen Escobedo-Lucea, Carolina Gandia, Sonia Tarazona, Dario Melguizo, David Blesa, David Montaner, Silvia Sanz-González, Pilar Sepúlveda, Stefan Götz, José Enrique O'Connor, Rubén Moreno, Joaquín Dopazo, Deborah J. Burks, Miodrag Stojkovic
Published Online: 4 Jan 2010
DOI 10.1002/stem.295

Pages 419-430
Distinguishing Between Mouse and Human Pluripotent Stem Cell Regulation: The Best Laid Plans of Mice and Men
Angelique Schnerch, Chantal Cerdan, Mickie Bhatia
Published Online: 6 Jan 2010
DOI 10.1002/stem.298

Pages 431-442
Nitric Oxide Determines Mesodermic Differentiation of Mouse Embryonic Stem Cells by Activating Class IIa Histone Deacetylases: Potential Therapeutic Implications in a Mouse Model of Hindlimb Ischemia
Francesco Spallotta, Jessica Rosati, Stefania Straino, Simona Nanni, Annalisa Grasselli, Valeria Ambrosino, Dante Rotili, Sergio Valente, Antonella Farsetti, Antonello Mai, Maurizio C. Capogrossi, Carlo Gaetano, Barbara Illi
Published Online: 13 Jan 2010
DOI 10.1002/stem.300

Pages 443-449
Reprogramming of DNA Replication Timing
Yoel Shufaro, Orly Lacham-Kaplan, Ben-Zion Tzuberi, John McLaughlin, Alan Trounson, Howard Cedar, Benjamin E. Reubinoff
Published Online: 13 Jan 2010
DOI 10.1002/stem.303

Pages 450-461
DNA Damage-Induced Degradation of Cdc25A Does Not Lead to Inhibition of Cdk2 Activity in Mouse Embryonic Stem Cells
Zuzana Koledova, Leona Raskova Kafkova, Alwin Krämer, Vladimir Divoky
Published Online: 26 Jan 2010
DOI 10.1002/stem.311

Pages 462-469
Fhl2 Interacts with Foxk1 and Corepresses Foxo4 Activity in Myogenic Progenitors
Xiaozhong Shi, Kathy M. Bowlin, Daniel J. Garry
Published Online: 9 Dec 2009
DOI 10.1002/stem.274

Pages 470-479
Boundary Cap Cells are Highly Competitive for CNS Remyelination: Fast Migration and Efficient Differentiation in PNS and CNS Myelin-Forming Cells
V. Zujovic, J. Thibaud, C. Bachelin, M. Vidal, F. Coulpier, P. Charnay, P. Topilko, A. Baron-Van Evercooren
Published Online: 28 Dec 2009
DOI 10.1002/stem.290

Pages 480-488
Loss of LAP2 Delays Satellite Cell Differentiation and Affects Postnatal Fiber-Type Determination
Ivana Gotic, Wolfgang M. Schmidt, Katarzyna Biadasiewicz, Michael Leschnik, Rita Spilka, Juliane Braun, Colin L. Stewart, Roland Foisner
Published Online: 28 Dec 2009
DOI 10.1002/stem.292

Pages 489-500
Maximizing Functional Photoreceptor Differentiation From Adult Human Retinal Stem Cells
Tomoyuki Inoue, Brenda L.K. Coles, Kim Dorval, Rod Bremner, Yasumasa Bessho, Ryoichiro Kageyama, Shinjiro Hino, Masao Matsuoka, Cheryl M. Craft, Roderick R. McInnes, Francois Tremblay, Glen T. Prusky, Derek van der Kooy
Published Online: 11 Dec 2009
DOI 10.1002/stem.279

Pages 501-512
Foxa2 and Nurr1 Synergistically Yield A9 Nigral Dopamine Neurons Exhibiting Improved Differentiation, Function, and Cell Survival
Hyun-Seob Lee, Eun-Ji Bae, Sang-Hoon Yi, Jae-Won Shim, A-Young Jo, Jin-Sun Kang, Eun-Hye Yoon, Yong-Hee Rhee, Chang-Hwan Park, Hyun-Chul Koh, Hyun-Jung Kim, Hueng-Sik Choi, Jeung-Whan Han, Yong-Sung Lee, Jaesang Kim, Jia-Yi Li, Patrik Brundin, Sang-Hun Lee
Published Online: 4 Jan 2010
DOI 10.1002/stem.294

Pages 513-522
Life-Sparing Effect of Human Cord Blood-Mesenchymal Stem Cells in Experimental Acute Kidney Injury
Marina Morigi, Cinzia Rota, Tiziana Montemurro, Elisa Montelatici, Viviana Lo Cicero, Barbara Imberti, Mauro Abbate, Carla Zoja, Paola Cassis, Lorena Longaretti, Paolo Rebulla, Martino Introna, Chiara Capelli, Ariela Benigni, Giuseppe Remuzzi, Lorenza Lazzari
Published Online: 4 Jan 2010
DOI 10.1002/stem.293

Pages 523-534
Inhibition of Aldehyde Dehydrogenase Expands Hematopoietic Stem Cells with Radioprotective Capacity
Garrett G. Muramoto, J. Lauren Russell, Rachid Safi, Alice B. Salter, Heather A. Himburg, Pamela Daher, Sarah K. Meadows, Phuong Doan, Robert W. Storms, Nelson J. Chao, Donald P. McDonnell, John P. Chute
Published Online: 6 Jan 2010v
DOI 10.1002/stem.299

Pages 535-544
CCAAT/Enhancer Binding Protein Beta Regulates Stem Cell Activity and Specifies Luminal Cell Fate in the Mammary Gland
Heather L. LaMarca, Adriana P. Visbal, Chad J. Creighton, Hao Liu, Yiqun Zhang, Fariba Behbod, Jeffrey M. Rosen
Published Online: 6 Jan 2010
DOI 10.1002/stem.297

Pages 545-554
Subventricular Zone-Derived Neural Progenitor Cells Migrate Along a Blood Vessel Scaffold Toward The Post-stroke Striatum
Takuro Kojima, Yuki Hirota, Masatsugu Ema, Satoru Takahashi, Ichiro Miyoshi, Hideyuki Okano, Kazunobu Sawamoto
Published Online: 13 Jan 2010
DOI 10.1002/stem.306

Pages 555-563
Reactive Oxygen Species Inhibit Adhesion of Mesenchymal Stem Cells Implanted into Ischemic Myocardium via Interference of Focal Adhesion Complex
Heesang Song, Min-Ji Cha, Byeong-Wook Song, Il-Kwon Kim, Woochul Chang, Soyeon Lim, Eun Ju Choi, Onju Ham, Se-Yeon Lee, Namsik Chung, Yangsoo Jang, Ki-Chul Hwang
Published Online: 13 Jan 2010
DOI 10.1002/stem.302

Pages 564-572
Stem Cell Shape Regulates a Chondrogenic Versus Myogenic Fate Through Rac1 and N-Cadherin
Lin Gao, Rowena McBeath, Christopher S. Chen
Published Online: 15 Jan 2010
DOI 10.1002/stem.308

Pages 573-584
Mouse Kidney Progenitor Cells Accelerate Renal Regeneration and Prolong Survival after Ischemic Injury
Po-Tsang Lee, Hsi-Hui Lin, Si-Tse Jiang, Pei-Jung Lu, Kang-Ju Chou, Hua-Chang Fang, Yuan-Yow Chiou, Ming-Jer Tang
Published Online: 22 Jan 2010
DOI 10.1002/stem.310

Pages 585-596
Mesenchymal Stromal Cells: Current Understanding and Clinical Status
Husein K. Salem, Chris Thiemermann
Published Online: 4 Dec 2009
DOI 10.1002/stem.269

Pages 597-610
Successful Clinical Implementation of Corneal Epithelial Stem Cell Therapy for Treatment of Unilateral Limbal Stem Cell Deficiency
Sai Kolli, Sajjad Ahmad, Majlinda Lako, Francisco Figueiredo
Published Online: 10 Dec 2009
DOI 10.1002/stem.276

Pages 611-619
High-Throughput Flow Cytometry Purification of Transduced Progenitors Expressing Defined Levels of Vascular Endothelial Growth Factor Induces Controlled Angiogenesis In Vivo
Heidi Misteli, Thomas Wolff, Philipp Füglistaler, Roberto Gianni-Barrera, Lorenz Gürke, Michael Heberer, Andrea Banfi
Published Online: 28 Dec 2009
DOI 10.1002/stem.291

Pages 620-632
Development and Function of Myeloid-Derived Suppressor Cells Generated From Mouse Embryonic and Hematopoietic Stem Cells
Zuping Zhou, Deborah L. French, Ge Ma, Samuel Eisenstein, Ying Chen, Celia M. Divino, Gordon Keller, Shu-Hsia Chen, Ping-Ying Pan
Published Online: 13 Jan 2010
DOI 10.1002/stem.301

Pages 633-634
Validation of βActin Used as Endogenous Control for Gene Expression Analysis in Mechanobiology Studies: Amendments
Grit Kasper, Andrea Ode, Aline Groothuis, Juliane Glaeser, Timo Gaber, Cameron J. Wilson, Sven Geissler, Georg N. Duda
Published Online: 13 Jan 2010
DOI 10.1002/stem.305

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Stem Cells Accepted Articles for April 2nd

manojhind2001us@gmail.com (Manoj Kumar Valluru) — Wed, 07 Apr 2010 03:03:24 PDT

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Stem Cells Express (Accepted Articles)

Tissue-Specific Stem Cells

Adult Ciliary Epithelial Cells, Previously Identified as Retinal Stem Cells with Potential for Retinal Repair, Fail to Differentiate into New Rod Photoreceptors (p n/a)
S Gualdoni, M Baron, J Lakowski, S Decembrini, AJ Smith, RA Pearson, RR Ali, JC Sowden
Accepted Article Online: Mar 31 2010 1:53PM
DOI: 10.1002/stem.423

Translational and Clinical Research

Bone Marrow Derived Stem/Progenitor Cells in Cutaneous Repair and Regeneration (p n/a)
Yaojiong Wu, Robert CH. Zhao, Edward E. Tredget
Accepted Article Online: Mar 29 2010 3:00PM
DOI: 10.1002/stem.420

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Nature Cell Biology contents: April 2010 Volume 12 Number 4, pp 307 - 412

manojhind2001us@gmail.com (Manoj Kumar Valluru) — Thu, 01 Apr 2010 11:26:20 PDT

NATURE CELL BIOLOGY

April 2010 Volume 12 Number 4, pp 307 - 412

Visit Nature Cell Biology online to browse the journal.

Now available at http://links.ealert.nature.com/ctt?kn=63&m=34751781&r=MTc2NDEyMTk0MQS2&b=2&j=NzA0NTk1OTMS1&mt=1&rt=0

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----------------------
EDITORIAL
----------------------
A maturing European Research Council p307
doi:10.1038/ncb0410-307
The European Research Council aims to support frontier research by
individual research groups. As the organization enters its fourth year,
we hope that it will be better able to implement these scientific goals.
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----------------------
NEWS AND VIEWS
----------------------
Abscission accomplished by PtdIns(3)P pp308 - 310
Guillaume Montagnac and Philippe Chavrier
doi:10.1038/ncb0410-308
Cytokinesis - the final step of mitosis in which the two daughter cells
separate - requires accumulation of specific proteins and lipids at the
connecting bridge to ensure cleavage by abscission. Phosphatidylinositol-3-phosphate
(PtdIns(3)P), an endosomal phosphoinositide, and FYVE-CENT, a PtdIns3P-binding
protein, are found in the bridge, where they contribute to the mechanism of abscission.
http://links.ealert.nature.com/ctt?kn=18&m=34751781&r=MTc2NDEyMTk0MQS2&b=2&j=NzA0NTk1OTMS1&mt=1&rt=0

Cdc25A and Dub3 in a high-stakes balancing act pp311 - 313
Sebastian D. Hayes and J. Wade Harper
doi:10.1038/ncb2043
The deubiquitylating enzyme Dub3 is found to have oncogenic potential by
stabilizing the Cdc25A protein phosphatase, a crucial regulator of
cell-cycle progression.
http://links.ealert.nature.com/ctt?kn=16&m=34751781&r=MTc2NDEyMTk0MQS2&b=2&j=NzA0NTk1OTMS1&mt=1&rt=0

Cilia self-organize in response to planar cell polarity and flow pp314 - 315
Wallace F. Marshall
doi:10.1038/ncb0410-314
Cilia drive fluid flow in development and physiology, but this requires
that all cilia in a tissue orient the same way. Earlier studies indicated
that both planar cell polarity (PCP) signalling and cilia-generated fluid
flows could influence ciliary orientation. We now learn how asymmetric
localization of PCP proteins influences the position and orientation of
cilia to control the direction of flow.
http://links.ealert.nature.com/ctt?kn=14&m=34751781&r=MTc2NDEyMTk0MQS2&b=2&j=NzA0NTk1OTMS1&mt=1&rt=0

----------------------
RESEARCH HIGHLIGHTS
----------------------
Research highlights p316
doi:10.1038/ncb0410-316
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=====================================================================

----------------------
ARTICLES
----------------------
Molecular control of kinetochore-microtubule dynamics and chromosome
oscillations pp319 - 329
Ana C. Amaro et al.
doi:10.1038/ncb2033
The core kinetochore protein CENP-H is shown to be required for the
organization of the metaphase plate. CENP-H regulates microtubule
plus-end dynamics, and chromosome oscillations, which are shown to
be essential for chromosome congression.
Abstract: http://links.ealert.nature.com/ctt?kn=22&m=34751781&r=MTc2NDEyMTk0MQS2&b=2&j=NzA0NTk1OTMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=52&m=34751781&r=MTc2NDEyMTk0MQS2&b=2&j=NzA0NTk1OTMS1&mt=1&rt=0

Protein complexes containing CYFIP/Sra/PIR121 coordinate Arf1 and Rac1
signalling during clathrin-AP-1-coated carrier biogenesis at the TGN
pp330 - 340
Mihaela Anitei et al.
doi:10.1038/ncb2034
How membrane deformation and actin remodelling are coordinated to
generate functional transport vesicles remains poorly understood.
ARF1 coordinates clathrin coat recruitment and actin polymerization
by binding the clathrin heavy chain binding protein, CYFIP, and facilitates
Rac1-dependent actin polymerization to generate transport carriers at
the trans-Golgi network.
Abstract: http://links.ealert.nature.com/ctt?kn=24&m=34751781&r=MTc2NDEyMTk0MQS2&b=2&j=NzA0NTk1OTMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=58&m=34751781&r=MTc2NDEyMTk0MQS2&b=2&j=NzA0NTk1OTMS1&mt=1&rt=0

Coupling between hydrodynamic forces and planar cell polarity orients
mammalian motile cilia pp341 - 350
Boris Guirao et al.
doi:10.1038/ncb2040
Motile cilia direct efficient, oriented flow, which is ensured by
alignment of their beating. In mammalian brain ventricles, coupling
between hydrodynamic forces and the planar cell polarity protein
Vangl2 allows cilia that have docked in random orientation to reorient
in a uniform direction.
Abstract: http://links.ealert.nature.com/ctt?kn=25&m=34751781&r=MTc2NDEyMTk0MQS2&b=2&j=NzA0NTk1OTMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=45&m=34751781&r=MTc2NDEyMTk0MQS2&b=2&j=NzA0NTk1OTMS1&mt=1&rt=0

A deneddylase encoded by Epstein-Barr virus promotes viral DNA replication
by regulating the activity of cullin-RING ligases pp351 - 361
Stefano Gastaldello et al.
doi:10.1038/ncb2035
BPLF1 is a viral NEDD8-specific protease that binds to cullin-based
ubiquitin ligases and regulates the turnover of their substrates.
By inducing the accumulation of the licensing factor CDT1, BPLF1 ensures
efficient replication of the viral genome and has a key role in the
virus life cycle.
Abstract: http://links.ealert.nature.com/ctt?kn=26&m=34751781&r=MTc2NDEyMTk0MQS2&b=2&j=NzA0NTk1OTMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=95&m=34751781&r=MTc2NDEyMTk0MQS2&b=2&j=NzA0NTk1OTMS1&mt=1&rt=0

PtdIns(3)P controls cytokinesis through KIF13A-mediated recruitment
of FYVE-CENT to the midbody pp362 - 371
Antonia P. Sagona et al.
doi:10.1038/ncb2036
A new link is reported between regulators of endosomal trafficking
and cytokinesis. Production of the phosphoinositide lipid PI3P at
the midbody triggers the KIF13A-mediated recruitment of the centrosomal
proteins FYVE-CENT and TTC19 to the division site. TTC19 may in turn
regulate abscission by control of the ESCRTIII complex.
Abstract: http://links.ealert.nature.com/ctt?kn=28&m=34751781&r=MTc2NDEyMTk0MQS2&b=2&j=NzA0NTk1OTMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=92&m=34751781&r=MTc2NDEyMTk0MQS2&b=2&j=NzA0NTk1OTMS1&mt=1&rt=0

Genome-wide RNA-mediated interference screen identifies miR-19 targets
in Notch-induced T-cell acute lymphoblastic leukaemia pp372 - 379
Konstantinos J. Mavrakis et al.
doi:10.1038/ncb2037
The 17-92 miRNA cluster promotes tumourigenesis, although the identity
of the specific miRNA responsible for this effect has been unclear.
miR-19 is sufficient to promote Notch induced T-cell associated leukaemia
in vivo and a shRNA screen for genes that phenocopy miR-19 effects
identifies PI3-K regulators as miR-19 target genes.
Abstract: http://links.ealert.nature.com/ctt?kn=29&m=34751781&r=MTc2NDEyMTk0MQS2&b=2&j=NzA0NTk1OTMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=93&m=34751781&r=MTc2NDEyMTk0MQS2&b=2&j=NzA0NTk1OTMS1&mt=1&rt=0

BRD7 is a candidate tumour suppressor gene required for p53 function
pp380 - 389
Jarno Drost et al.
doi:10.1038/ncb2038
Oncogene expression can induce permanent cell-cycle arrest by activating
the p53 pathway. BRD7 positively regulates p53 transcriptional activity
in this context by interacting with p300 and stimulating acetylation
of both p53 and histones.
Abstract: http://links.ealert.nature.com/ctt?kn=30&m=34751781&r=MTc2NDEyMTk0MQS2&b=2&j=NzA0NTk1OTMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=74&m=34751781&r=MTc2NDEyMTk0MQS2&b=2&j=NzA0NTk1OTMS1&mt=1&rt=0

Gain of miR-151 on chromosome 8q24.3 facilitates tumour cell migration
and spreading through downregulating RhoGDIA pp390 - 399
Jie Ding et al.
doi:10.1038/ncb2039
Twenty-two microRNAs are found to be amplified or deleted in hepatocellular
carcinoma (HCC). miR-151 is encoded by an intron in the focal adhesion
kinase FAK-1 gene, with which it is co-transcribed, and increases HCC
cell migration in vitro and invasion in vivo by directly targeting RhoGDIA.
miR-151 amplification correlates with HCC metastasis.
Abstract: http://links.ealert.nature.com/ctt?kn=9&m=34751781&r=MTc2NDEyMTk0MQS2&b=2&j=NzA0NTk1OTMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=82&m=34751781&r=MTc2NDEyMTk0MQS2&b=2&j=NzA0NTk1OTMS1&mt=1&rt=0

----------------------
LETTERS
----------------------
Ubiquitin hydrolase Dub3 promotes oncogenic transformation by
stabilizing Cdc25A pp400 - 406
Yaron Pereg et al.
doi:10.1038/ncb2041
The levels of the cell cycle phosphatase Cdc25A are controlled by
proteolysis. A de-ubiquitylation enzyme, Dub3, stabilizes Cdc25A,
is required for Cdc25A-mediated activation of Cdk1, and may
contribute to oncogenic transformation by Cdc25A.
Abstract: http://links.ealert.nature.com/ctt?kn=6&m=34751781&r=MTc2NDEyMTk0MQS2&b=2&j=NzA0NTk1OTMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=79&m=34751781&r=MTc2NDEyMTk0MQS2&b=2&j=NzA0NTk1OTMS1&mt=1&rt=0

Vangl2 directs the posterior tilting and asymmetric localization of
motile primary cilia pp407 - 412
Antonia Borovina, Simone Superina, Daniel Voskas and Brian Ciruna
doi:10.1038/ncb2042
Several recent studies have proposed that the planar cell polarity
pathway (PCP) regulates cilia formation. Zebrafish embryos lacking
the core PCP component Vangl2 do not have defects in ciliogenesis,
but instead show impairment of primary cilia position and orientation.
Abstract: http://links.ealert.nature.com/ctt?kn=8&m=34751781&r=MTc2NDEyMTk0MQS2&b=2&j=NzA0NTk1OTMS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=73&m=34751781&r=MTc2NDEyMTk0MQS2&b=2&j=NzA0NTk1OTMS1&mt=1&rt=0

----------------------
CORRIGENDUM
----------------------
HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors
on damaged chromosomes p412
Simon Bekker-Jensen et al.
doi:10.1038/ncb0410-412
http://links.ealert.nature.com/ctt?kn=32&m=34751781&r=MTc2NDEyMTk0MQS2&b=2&j=NzA0NTk1OTMS1&mt=1&rt=0

=========================== ADVERTISEMENT ===========================

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Oncogene - Table of Contents alert Volume 29 Issue 13

manojhind2001us@gmail.com (Manoj Kumar Valluru) — Thu, 01 Apr 2010 11:26:20 PDT

ONCOGENE

April 2010 Volume 29 Number 13, pp 1865 - 2012

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Call for papers - Nature Communications

Nature Communications, an innovative new online science journal,
launching in spring 2010, is now accepting submissions. The journal
will provide a unique forum for the rapid publication of high-quality
Articles, from short communications to longer format research papers,
covering all areas of the physical, chemical and biological sciences.

Submit now at http://links.ealert.nature.com/ctt?kn=12&m=34751488&r=MTc2ODI0Mjc1MwS2&b=2&j=NzA0NTcwMTgS1&mt=1&rt=0

----------------------
REVIEW
----------------------
Dependence receptors: a new paradigm in cell signaling and cancer therapy
D Goldschneider and P Mehlen
Abstract: http://links.ealert.nature.com/ctt?kn=55&m=34751488&r=MTc2ODI0Mjc1MwS2&b=2&j=NzA0NTcwMTgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=69&m=34751488&r=MTc2ODI0Mjc1MwS2&b=2&j=NzA0NTcwMTgS1&mt=1&rt=0

----------------------
ORIGINAL ARTICLES
----------------------
Heat shock protein 27 confers resistance to androgen ablation and
chemotherapy in prostate cancer cells through eIF4E
C Andrieu, D Taieb, V Baylot, S Ettinger, P Soubeyran, A De-Thonel,
C Nelson, C Garrido, A So, L Fazli, F Bladou, M Gleave, J L Iovanna and
P Rocchi
Abstract: http://links.ealert.nature.com/ctt?kn=70&m=34751488&r=MTc2ODI0Mjc1MwS2&b=2&j=NzA0NTcwMTgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=67&m=34751488&r=MTc2ODI0Mjc1MwS2&b=2&j=NzA0NTcwMTgS1&mt=1&rt=0

Genome-wide single-nucleotide polymorphism arrays in endometrial carcinomas
associate extensive chromosomal instability with poor prognosis and
unveil frequent chromosomal imbalances involved in the PI3-kinase pathway
S Murayama-Hosokawa, K Oda, S Nakagawa, S Ishikawa, S Yamamoto, K Shoji,
Y Ikeda, Y Uehara, M Fukayama, F McCormick, T Yano, Y Taketani and
H Aburatani
Abstract: http://links.ealert.nature.com/ctt?kn=68&m=34751488&r=MTc2ODI0Mjc1MwS2&b=2&j=NzA0NTcwMTgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=65&m=34751488&r=MTc2ODI0Mjc1MwS2&b=2&j=NzA0NTcwMTgS1&mt=1&rt=0

Thyroid hormone receptors are tumor suppressors in a mouse model of
metastatic follicular thyroid carcinoma
X-G Zhu, L Zhao, M C Willingham and S-Y Cheng
Abstract: http://links.ealert.nature.com/ctt?kn=66&m=34751488&r=MTc2ODI0Mjc1MwS2&b=2&j=NzA0NTcwMTgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=61&m=34751488&r=MTc2ODI0Mjc1MwS2&b=2&j=NzA0NTcwMTgS1&mt=1&rt=0

A novel XPF -357A>C polymorphism predicts risk and recurrence of bladder
cancer
M Wang, M Wang, L Yuan, D Wu, Z Zhang, C Yin, G Fu, Q Wei and Z Zhang
Abstract: http://links.ealert.nature.com/ctt?kn=62&m=34751488&r=MTc2ODI0Mjc1MwS2&b=2&j=NzA0NTcwMTgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=71&m=34751488&r=MTc2ODI0Mjc1MwS2&b=2&j=NzA0NTcwMTgS1&mt=1&rt=0

p53 suppresses structural chromosome instability after mitotic arrest in
human cells
W B Dalton, B Yu and V W Yang
Abstract: http://links.ealert.nature.com/ctt?kn=25&m=34751488&r=MTc2ODI0Mjc1MwS2&b=2&j=NzA0NTcwMTgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=26&m=34751488&r=MTc2ODI0Mjc1MwS2&b=2&j=NzA0NTcwMTgS1&mt=1&rt=0

Osteopontin-mediated enhanced hyaluronan binding induces multidrug
resistance in mesothelioma cells
K Tajima, R Ohashi, Y Sekido, T Hida, T Nara, M Hashimoto, S Iwakami,
K Minakata, T Yae, F Takahashi, H Saya and K Takahashi
Abstract: http://links.ealert.nature.com/ctt?kn=27&m=34751488&r=MTc2ODI0Mjc1MwS2&b=2&j=NzA0NTcwMTgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=28&m=34751488&r=MTc2ODI0Mjc1MwS2&b=2&j=NzA0NTcwMTgS1&mt=1&rt=0

HSP72 depletion suppresses [gamma]H2AX activation by genotoxic stresses via
p53/p21 signaling
V L Gabai, M Y Sherman and J A Yaglom
Abstract: http://links.ealert.nature.com/ctt?kn=29&m=34751488&r=MTc2ODI0Mjc1MwS2&b=2&j=NzA0NTcwMTgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=30&m=34751488&r=MTc2ODI0Mjc1MwS2&b=2&j=NzA0NTcwMTgS1&mt=1&rt=0

Identification of Zfp521/ZNF521 as a cooperative gene for E2A-HLF to
develop acute B-lineage leukemia
N Yamasaki, K Miyazaki, A Nagamachi, R Koller, H Oda, M Miyazaki,
T Sasaki, Z-i Honda, L Wolff, T Inaba and H Honda
Abstract: http://links.ealert.nature.com/ctt?kn=31&m=34751488&r=MTc2ODI0Mjc1MwS2&b=2&j=NzA0NTcwMTgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=32&m=34751488&r=MTc2ODI0Mjc1MwS2&b=2&j=NzA0NTcwMTgS1&mt=1&rt=0

ARF-induced downregulation of Mip130/LIN-9 protein levels mediates a
positive feedback that leads to increased expression of p16Ink4a and p19Arf
J Song, R Sandoval, M A Pilkinton, X Tian, P Raychaudhuri and O R Colamonici
Abstract: http://links.ealert.nature.com/ctt?kn=34&m=34751488&r=MTc2ODI0Mjc1MwS2&b=2&j=NzA0NTcwMTgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=37&m=34751488&r=MTc2ODI0Mjc1MwS2&b=2&j=NzA0NTcwMTgS1&mt=1&rt=0

Induction of anion exchanger-1 translation and its opposite roles in
the carcinogenesis of gastric cancer cells and differentiation of K562 cells
J Wu, Y-C Zhang, W-H Suo, X-B Liu, W-W Shen, H Tian and G-H Fu
Abstract: http://links.ealert.nature.com/ctt?kn=48&m=34751488&r=MTc2ODI0Mjc1MwS2&b=2&j=NzA0NTcwMTgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=5&m=34751488&r=MTc2ODI0Mjc1MwS2&b=2&j=NzA0NTcwMTgS1&mt=1&rt=0

----------------------
SHORT COMMUNICATIONS
----------------------
Alternative splicing of p53 and p73: the novel p53 splice variant
p53[delta] is an independent prognostic marker in ovarian cancer
G Hofstetter, A Berger, H Fiegl, N Slade, A Zoric, B Holzer, E Schuster,
V J Mobus, D Reimer, G Daxenbichler, C Marth, A G Zeimet, N Concin and R Zeillinger
Abstract: http://links.ealert.nature.com/ctt?kn=6&m=34751488&r=MTc2ODI0Mjc1MwS2&b=2&j=NzA0NTcwMTgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=1&m=34751488&r=MTc2ODI0Mjc1MwS2&b=2&j=NzA0NTcwMTgS1&mt=1&rt=0

OGG1 is a novel prognostic indicator in acute myeloid leukaemia
K Liddiard, R Hills, A K Burnett, R L Darley and A Tonks
Abstract: http://links.ealert.nature.com/ctt?kn=3&m=34751488&r=MTc2ODI0Mjc1MwS2&b=2&j=NzA0NTcwMTgS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=8&m=34751488&r=MTc2ODI0Mjc1MwS2&b=2&j=NzA0NTcwMTgS1&mt=1&rt=0

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Current Opinion in Cellular Host-Pathogen Interactions

manojhind2001us@gmail.com (Manoj Kumar Valluru) — Thu, 01 Apr 2010 11:26:20 PDT

Current Opinion in Cellular Host-Pathogen Interactions: Call for Papers
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A Current Opinion Conference
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CALL FOR PAPERS: Abstract Submission Deadline - April 16, 2010

Please print this email and hang on your bulletin board!

THE ORGANIZERS
Current Opinion in Cellular Host-Pathogen Interactions is organized by Elsevier in association with Current Opinion in Cell Biology

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Avoid missing the deadline...
Submit your abstract online here!

With only a few days left to submit your abstract, time is running out! Don't miss out on the opportunity to submit your research for presentation at this year's conference. Abstracts are invited by 16 April, 2010 for oral and poster presentation of original research on the following topics:

Life cycle of pathogens (viruses, bacteria and unicellular eukaryotes)
Strategies used by pathogens to invade organisms and cells
Mechanisms that allow pathogens to survive within organisms and cells
Strategies used by pathogens to spread throughout the organism
Host defense against pathogens

THE PROGRAMME

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Ari Helenius, ETH, Zurich, Switzerland
Paul Lehner, University of Cambridge, UK
Mark Marsh, LMCB, University College London, UK
Keith Matthews, University of Edinburgh, UK
David Roos, University of Pennsylvania, USA
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David Russell, Cornell University, USA
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Michael Way, Cancer Research UK, UK

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Cell Research - Table of Contents alert Volume 20 Issue 4

manojhind2001us@gmail.com (Manoj Kumar Valluru) — Thu, 01 Apr 2010 11:26:20 PDT

CELL RESEARCH

April 2010 Volume 20 Number 4, pp 391 - 498

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----------------------
RESEARCH HIGHLIGHTS
----------------------
Mcl1 becomes ubiquitin-ous: new opportunities to antagonize a pro-survival protein
Michael D Hogarty
http://links.ealert.nature.com/ctt?kn=85&m=34750948&r=MTc2MDE3NzA4MwS2&b=2&j=NzA0NTExNTUS1&mt=1&rt=0

Mad revival of cancer
Hong Liu and Hongtao Yu
http://links.ealert.nature.com/ctt?kn=83&m=34750948&r=MTc2MDE3NzA4MwS2&b=2&j=NzA0NTExNTUS1&mt=1&rt=0

Divalent metal transporter, iron, and Parkinson's disease: A pathological relationship
Hyun-pil Lee, Xiongwei Zhu, Gang Liu, Shu G Chen, George Perry, Mark A Smith and Hyoung-gon Lee
http://links.ealert.nature.com/ctt?kn=68&m=34750948&r=MTc2MDE3NzA4MwS2&b=2&j=NzA0NTExNTUS1&mt=1&rt=0

----------------------
REVIEW
----------------------
Polyglutamine toxicity in non-neuronal cells
Jennifer W Bradford, Shihua Li and Xiao-Jiang Li
Abstract: http://links.ealert.nature.com/ctt?kn=69&m=34750948&r=MTc2MDE3NzA4MwS2&b=2&j=NzA0NTExNTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=40&m=34750948&r=MTc2MDE3NzA4MwS2&b=2&j=NzA0NTExNTUS1&mt=1&rt=0

----------------------
ORIGINAL ARTICLES
----------------------
A de novo originated gene depresses budding yeast mating pathway and is repressed by the protein
encoded by its antisense strand
Dan Li, Yang Dong, Yu Jiang, Huifeng Jiang, Jing Cai and Wen Wang
Abstract: http://links.ealert.nature.com/ctt?kn=59&m=34750948&r=MTc2MDE3NzA4MwS2&b=2&j=NzA0NTExNTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=56&m=34750948&r=MTc2MDE3NzA4MwS2&b=2&j=NzA0NTExNTUS1&mt=1&rt=0

The mitochondrial serine protease HtrA2/Omi cleaves RIP1 during apoptosis of Ba/F3 cells induced
by growth factor withdrawal
Lieselotte Vande Walle, Ellen Wirawan, Mohamed Lamkanfi, Nele Festjens, Jelle Verspurten,
Xavier Saelens, Tom Vanden Berghe and Peter Vandenabeele
Abstract: http://links.ealert.nature.com/ctt?kn=64&m=34750948&r=MTc2MDE3NzA4MwS2&b=2&j=NzA0NTExNTUS1&mt=1&rt=0
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Human fetal mesenchymal stem cells differentiate into brown and white adipocytes: a role for
ERR[alpha] in human UCP1 expression
Daniel L Morganstein, Pensee Wu, Meritxell R Mane, Nick M Fisk, Roger White and Malcolm G Parker
Abstract: http://links.ealert.nature.com/ctt?kn=48&m=34750948&r=MTc2MDE3NzA4MwS2&b=2&j=NzA0NTExNTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=46&m=34750948&r=MTc2MDE3NzA4MwS2&b=2&j=NzA0NTExNTUS1&mt=1&rt=0

Length of the ORF, position of the first AUG and the Kozak motif are important factors in
potential dual-coding transcripts
Heng Xu, Ping Wang, Yujie Fu, Yufang Zheng, Quan Tang, Lizhen Si, Jin You, Zhenguo Zhang,
Yufei Zhu, Li Zhou, Zejun Wei, Bin Lin, Landian Hu and Xiangyin Kong
Abstract: http://links.ealert.nature.com/ctt?kn=52&m=34750948&r=MTc2MDE3NzA4MwS2&b=2&j=NzA0NTExNTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=50&m=34750948&r=MTc2MDE3NzA4MwS2&b=2&j=NzA0NTExNTUS1&mt=1&rt=0

BCL2 inhibits cell adhesion, spreading, and motility by enhancing actin polymerization
Hengning Ke, Vandy I Parron, Jeff Reece, Jennifer Y Zhang, Steven K Akiyama and John E French
Abstract: http://links.ealert.nature.com/ctt?kn=31&m=34750948&r=MTc2MDE3NzA4MwS2&b=2&j=NzA0NTExNTUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=75&m=34750948&r=MTc2MDE3NzA4MwS2&b=2&j=NzA0NTExNTUS1&mt=1&rt=0

C/EBP[alpha] regulates SIRT1 expression during adipogenesis
Qihuang Jin, Fang Zhang, Tingting Yan, Zhen Liu, Chunxi Wang, Xinjian Ge and Qiwei Zhai
Abstract: http://links.ealert.nature.com/ctt?kn=74&m=34750948&r=MTc2MDE3NzA4MwS2&b=2&j=NzA0NTExNTUS1&mt=1&rt=0
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High doses of [alpha]-galactosylceramide potentiate experimental autoimmune encephalomyelitis by
directly enhancing Th17 response
Gaochao Qian, Xia Qin, Ying Qin Zang, Baoxue Ge, Taylor B. Guo, Bing Wan, Lei Fang and Jingwu Z. Zhang
Abstract: http://links.ealert.nature.com/ctt?kn=92&m=34750948&r=MTc2MDE3NzA4MwS2&b=2&j=NzA0NTExNTUS1&mt=1&rt=0
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----------------------
LETTERS TO THE EDITOR
----------------------
Palmitate impairs cytokinesis associated with RhoA inhibition
Jianhua Zhang, Ying Yang and Jiarui Wu
http://links.ealert.nature.com/ctt?kn=87&m=34750948&r=MTc2MDE3NzA4MwS2&b=2&j=NzA0NTExNTUS1&mt=1&rt=0

Sua5p is required for telomere recombination in Saccharomyces cerevisiae
Fei-Long Meng, Xiao-Fen Chen, Yan Hu, Hong-Bo Tang, Wei Dang and Jin-Qiu Zhou
http://links.ealert.nature.com/ctt?kn=84&m=34750948&r=MTc2MDE3NzA4MwS2&b=2&j=NzA0NTExNTUS1&mt=1&rt=0

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Cord Blood America Discusses China, Annual Financial Report

manojhind2001us@gmail.com (Manoj Kumar Valluru) — Thu, 01 Apr 2010 11:26:20 PDT

Release #:812-76904-em-434148:

Cord Blood America Discusses China, Annual Financial Report

Cord Blood America's CEO Matthew Schissler, In Analyst Interview, Discusses China Expansion

LAS VEGAS, April 1 /PRNewswire-FirstCall/ -- Cord Blood America, Inc. (OTC Bulletin Board: CBAI), the umbilical cord blood stem cell preservation company (http://www.cordblood-america.com ), is focused on bringing the life saving potential of stem cells, a biological insurance policy, to families nationwide and internationally. Its CEO and co-founder, Matthew Schissler, in an interview with analyst Francis Gaskins, said its recent announcement to build the world's largest stem cell storage facility in China, in conjunction with AXM Pharma, Inc. (Pink Sheets: AXMP), makes great sense for three reasons:

A higher percentage of Chinese are interested in storing stem cells than in populations in the U.S. and Europe.
The barriers to entry into China are high and expensive. By partnering with a Company which is already successful, and which holds key government licenses, Cord Blood America sees a pathway to success.
China is the world's most populous country and Cord Blood America needs representation there to move forward with its worldwide growth strategy.

The entire interview is available at http://gaskinsco.com/cbai-3-31-10.mp3

The interview also features a discussion by Mr. Schissler of the Company's annual financial report, which was filed with the U.S. Securities & Exchange Commission this week. "We now have a healthy balance sheet compared to where we were 12 months ago," CBAI's CEO said. "The year 2010 will be dedicated to growing revenues."

About Cord Blood America

CONTACT:
Paul Knopick
E & E Communications
949/707-5365
pknopick@eandecommunications.com

SOURCE Cord Blood America, Inc.

Media Contact: Paul Knopick of E & E Communications, +1-949-707-5365, pknopick@eandecommunications.com, for Cord Blood America, Inc.

Web Site: http://www.cordblood-america.com
Web Site: http://www.corcell.com

My EANDE

More Information

Nature Reviews Rheumatology - Table of Contents alert Volume 6 Issue 4

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April 2010 Volume 6 Number 4

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----------------------
EDITORIAL
----------------------
Pain by name, pain by nature
Peter E. Lipsky and Jenny Buckland
p179 | doi:10.1038/nrrheum.2010.38
http://links.ealert.nature.com/ctt?kn=36&m=34750806&r=MTc2NDQ4MTc5OAS2&b=2&j=NzA0NDgzMzkS1&mt=1&rt=0

----------------------
RESEARCH HIGHLIGHTS
----------------------
Connective tissue diseases: Edging closer to the early detection of
renal flare in adult SLE
p181 | doi:10.1038/nrrheum.2010.28
http://links.ealert.nature.com/ctt?kn=34&m=34750806&r=MTc2NDQ4MTc5OAS2&b=2&j=NzA0NDgzMzkS1&mt=1&rt=0

Irinotecan: A new treatment for SLE?
p182 | doi:10.1038/nrrheum.2010.30
http://links.ealert.nature.com/ctt?kn=31&m=34750806&r=MTc2NDQ4MTc5OAS2&b=2&j=NzA0NDgzMzkS1&mt=1&rt=0

Metabolic bone diseases: Targeting gut-derived serotonin promotes bone
formation
p182 | doi:10.1038/nrrheum.2010.32
http://links.ealert.nature.com/ctt?kn=28&m=34750806&r=MTc2NDQ4MTc5OAS2&b=2&j=NzA0NDgzMzkS1&mt=1&rt=0

Experimental arthritis: Inducing tolerance with CD40 siRNA
p183 | doi:10.1038/nrrheum.2010.29
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Bim-BH3-mimetic therapy for RA
p183 | doi:10.1038/nrrheum.2010.31
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Bone: Blimp1 functions in bone homeostasis
p183 | doi:10.1038/nrrheum.2010.34
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Pharmacotherapy: Is monitoring methotrexate polyglutamates useful?
p184 | doi:10.1038/nrrheum.2010.33
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IN BRIEF
Connective tissue diseases | Rheumatoid arthritis | Connective tissue
diseases
p184 | doi:10.1038/nrrheum.2010.35
http://links.ealert.nature.com/ctt?kn=92&m=34750806&r=MTc2NDQ4MTc5OAS2&b=2&j=NzA0NDgzMzkS1&mt=1&rt=0

----------------------
NEWS AND VIEWS
----------------------
Acute inflammatory arthritis: Are glucocorticoids of benefit in very
early arthritis?
Klaus Machold
p185 | doi:10.1038/nrrheum.2010.39
Most forms of arthritis are 'undifferentiated' in the first few weeks
to months. Many experts believe this stage presents a unique opportunity
to influence the fate of a patient by initiating early treatment. The
STIVEA trial attempted to define the true benefit of glucocorticoids
in very early arthritis with regard to long-term outcomes.
http://links.ealert.nature.com/ctt?kn=43&m=34750806&r=MTc2NDQ4MTc5OAS2&b=2&j=NzA0NDgzMzkS1&mt=1&rt=0

Therapy: Surgery or nonsurgical therapy for carpal tunnel syndrome?
George S. M. Dyer and Barry P. Simmons
p186 | doi:10.1038/nrrheum.2010.41
A recent study of therapies for carpal tunnel syndrome suggests a clear
benefit for surgery, although the investigators also found improvements
in patients who received carefully structured, nonsurgical treatment.
http://links.ealert.nature.com/ctt?kn=44&m=34750806&r=MTc2NDQ4MTc5OAS2&b=2&j=NzA0NDgzMzkS1&mt=1&rt=0

Autoimmunity: Effectiveness of treatments for pregnant women with APS
Shari E. Gelber and Jane E. Salmon
p187 | doi:10.1038/nrrheum.2010.42
The combination of heparin and aspirin is widely regarded as 'standard
therapy' to increase rates of live birth in patients with recurrent
pregnancy loss and positive antiphospholipid antibodies. However, this
recommendation is based largely on expert opinion. Does a meta-analysis
of randomized controlled trials support the practice?
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=====================================================================
Focus on: Pain management
----------------------
REVIEWS
----------------------
Adverse effects of chronic opioid therapy for chronic musculoskeletal pain
Leslie J. Crofford
p191 | doi:10.1038/nrrheum.2010.24
In the absence of a safe and effective alternative treatment for chronic
musculoskeletal pain, the prescription of opioid analgesics has escalated
dramatically over the past decade. Their use, however, can be associated
with the persistence, or even enhancement, of chronic pain, and might
also induce powerful positively-reinforcing psychological effects that
lead to clinical dependence, as outlined in this Review.
Abstract: http://links.ealert.nature.com/ctt?kn=93&m=34750806&r=MTc2NDQ4MTc5OAS2&b=2&j=NzA0NDgzMzkS1&mt=1&rt=0
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Self-management of chronic low back pain and osteoarthritis
Stephen May
p199 | doi:10.1038/nrrheum.2010.26
Individuals with chronic back pain or osteoarthritis often do not seek
healthcare because of these problems, but instead make use of a range
of self-care strategies. This article explores several aspects of
self-management, and includes a review of the evidence for the effectiveness
of various self-management programs for these two musculoskeletal conditions.
Abstract: http://links.ealert.nature.com/ctt?kn=85&m=34750806&r=MTc2NDQ4MTc5OAS2&b=2&j=NzA0NDgzMzkS1&mt=1&rt=0
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Psychological approaches to understanding and treating arthritis pain
Francis J. Keefe and Tamara J. Somers
p210 | doi:10.1038/nrrheum.2010.22
In this Review, the authors describe the emotional, cognitive and social
context variables that contribute to arthritis pain, and how they have
been used to develop psychological approaches to pain management.
Abstract: http://links.ealert.nature.com/ctt?kn=87&m=34750806&r=MTc2NDQ4MTc5OAS2&b=2&j=NzA0NDgzMzkS1&mt=1&rt=0
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Surgical options for patients with shoulder pain
Salma Chaudhury, Stephen E. Gwilym, Jane Moser and Andrew J. Carr
p217 | doi:10.1038/nrrheum.2010.25
Surgery for painful shoulder conditions is usually only considered when
conservative treatment fails. This article outlines the features of and
indications for surgery in common painful conditions that affect the
shoulder.
Abstract: http://links.ealert.nature.com/ctt?kn=58&m=34750806&r=MTc2NDQ4MTc5OAS2&b=2&j=NzA0NDgzMzkS1&mt=1&rt=0
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=====================================================================
Focus on: Pain management
----------------------
PERSPECTIVES
----------------------
OPINION
The role of the rheumatologist in managing pain therapy
David Borenstein
p227 | doi:10.1038/nrrheum.2010.27
Despite the high number of patients who present to their rheumatologist
with pain, this symptom remains undertreated in the clinic. In this
Perspectives, David Borenstein explores reasons for the undertreatment
of pain in patients with rheumatic disease, and argues that the
rheumatologist's role in this regard should be brought to the forefront.
Abstract: http://links.ealert.nature.com/ctt?kn=61&m=34750806&r=MTc2NDQ4MTc5OAS2&b=2&j=NzA0NDgzMzkS1&mt=1&rt=0
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=====================================================================

----------------------
CORRECTION
----------------------
Osteoporosis impact on health and economics
N. Harvey, E. Dennison and C. Cooper
p184 | doi:10.1038/nrrheum.2010.57
http://links.ealert.nature.com/ctt?kn=50&m=34750806&r=MTc2NDQ4MTc5OAS2&b=2&j=NzA0NDgzMzkS1&mt=1&rt=0

----------------------
REVIEW
----------------------
IL-1 pathways in inflammation and human diseases
Cem Gabay, Celine Lamacchia and Gaby Palmer
Published online: 23 February 2010
p232 | doi:10.1038/nrrheum.2010.4
IL-1 has an important role in the pathogenesis of many hereditary and
non-hereditary autoinflammatory diseases. This Review examines the
biological functions of IL-1 and the use of IL-1-targeting agents in
the treatment of various human diseases.
Abstract: http://links.ealert.nature.com/ctt?kn=60&m=34750806&r=MTc2NDQ4MTc5OAS2&b=2&j=NzA0NDgzMzkS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=78&m=34750806&r=MTc2NDQ4MTc5OAS2&b=2&j=NzA0NDgzMzkS1&mt=1&rt=0

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Synching Europe's big science facilities
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Missing weapons
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Exotic matter: Another dimension for anyons
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Generation of electron beams carrying orbital angular momentum
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Mol. Biol. Cell MBoC In Press for 31 Mar 2010

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Articles
The Hydrophobic Core of the Sec61 Translocon Defines the Hydrophobicity Threshold for Membrane Integration Tina Junne, Lucyna Kocik, and Martin Spiess: Tina Junne, Lucyna Kocik, and Martin Spiess
Regulation of Lens Gap Junctions by TGFß Bruce A. Boswell, Judy K. VanSlyke, and Linda S. Musil: Bruce A. Boswell, Judy K. VanSlyke, and Linda S. Musil
Arf3 Is Activated Selectively by BIGs at the trans-Golgi Network Florin Manolea, Justin Chun, David W. Chen, Ian Clarke, Nathan Summerfeldt, Joel B. Dacks, and Paul Melançon: Florin Manolea, Justin Chun, David W. Chen, Ian Clarke, Nathan Summerfeldt, Joel B. Dacks, and Paul Melançon
A Domesticated piggyBac Transposase Plays a Key Role in Heterochromatin Dynamics and DNA Cleavage during Programmed DNA Deletion in Tetrahymena thermophila Chao-Yin Cheng, Alexander Vogt, Kazufumi Mochizuki, and Meng-Chao Yao: Chao-Yin Cheng, Alexander Vogt, Kazufumi Mochizuki, and Meng-Chao Yao
RNF-121 Is an ER-Membrane E3 Ubiquitin Ligase Involved in the Regulation of -Integrin Amir Darom, Ulrike Bening-Abu-Shach, and Limor Broday: Amir Darom, Ulrike Bening-Abu-Shach, and Limor Broday
Mitf Induction by RANKL Is Critical for Osteoclastogenesis Ssu-Yi Lu, Mengtao Li, and Yi-Ling Lin: Ssu-Yi Lu, Mengtao Li, and Yi-Ling Lin
Activation of the MAP Kinase, Slt2p, at Bud Tips Blocks a Late Stage of ER Inheritance in Saccharomyces cerevisiae Xia Li, Yunrui Du, Steven Siegel, Susan Ferro-Novick, and Peter Novick: Xia Li, Yunrui Du, Steven Siegel, Susan Ferro-Novick, and Peter Novick
Keratin 8/18 Modulation of Protein Kinase C-mediated Integrin-dependent Adhesion and Migration of Liver Epithelial Cells François Bordeleau, Luc Galarneau, Stéphane Gilbert, Anne Loranger, and Normand Marceau: François Bordeleau, Luc Galarneau, Stéphane Gilbert, Anne Loranger, and Normand Marceau

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