The Journal of Pediatrics RSS feed. https://www.jpeds.com/issues?journalCode=ympd&publicationCode=ympd&rss=yes Elsevier Inc. en © 2026 Published by Elsevier Inc. All rights reserved. The Journal of Pediatrics 0022-3476 2026-04-20-07:00 © 2026 Published by Elsevier Inc. All rights reserved. permissionshelpdesk@elsevier.com https://www.jpeds.com/article/S0022-3476(26)00139-3/fulltext?rss=yes To assess the extent to which food allergies and food-specific IgE levels in childhood and adolescence differ among children who had infant colic, excessive crying without colic, or neither condition. Associations of Colic and Excessive Crying in Infancy with Food Allergy Outcomes in Childhood and Adolescence Karen M. Switkowski, Emily Oken, Elisabeth M. Simonin, Kari C. Nadeau, Sheryl L. Rifas-Shiman, Jenifer R. Lightdale 10.1016/j.jpeds.2026.115111 The Journal of Pediatrics (2026) 2026-04-17 The Journal of Pediatrics 2026-04-17 Original Articles https://www.jpeds.com/article/S0022-3476(26)00138-1/fulltext?rss=yes To describe the association between parenting stress levels during early childhood and subsequent emotional health outcomes and resilience of their children with congenital heart disease (CHD) as young adults. Association of Parenting Stress in Early Childhood with Emotional Health and Resilience of Young Adults with Congenital Heart Disease Elizabeth A. Herrup, Amanda J. Shillingford, J.William Gaynor, Colleen F.B. Driscoll, Lyla Hampton, Bingqing Zhang, Keith Baxelbaum, Nancy Burnham 10.1016/j.jpeds.2026.115110 The Journal of Pediatrics (2026) 2026-04-17 The Journal of Pediatrics 2026-04-17 Original Articles https://www.jpeds.com/article/S0022-3476(26)00136-8/fulltext?rss=yes To characterize baseline xanthoma prevalence and severity in Alagille syndrome, assess their impact on quality of life, evaluate longitudinal changes in xanthoma burden with maralixibat therapy, and identify clinical and biochemical predictors of treatment response in children enrolled across 2 clinical trials. Maralixibat Improves Xanthomas and Hypercholesterolemia in Children with Alagille Syndrome: A Post Hoc Integrated Analysis From Two Clinical Trials Brett J. Hoskins, Douglas Mogul, Cece Chen, Wikrom Karnsakul 10.1016/j.jpeds.2026.115108 The Journal of Pediatrics (2026) 2026-04-17 The Journal of Pediatrics 2026-04-17 Original Articles https://www.jpeds.com/article/S0022-3476(26)00135-6/fulltext?rss=yes To determine the diagnostic performance of vibration controlled transient elastography (VCTE) measured the same day as liver biopsy in screening and risk stratification of steatosis and fibrosis in children and adolescents. Characteristics of Transient Elastography for Hepatic Steatosis and Fibrosis in Children Undergoing Liver Biopsy Jonathan B. Steinman, Ngoc Duong, Ivette Partida, Celine Bien-Aime, Wei Shen, Christine K. Lee, Ladan A. Fazlollahi, Helen E. Remotti, Utpal B. Pajvani, Jeff Goldsmith, Jennifer A. Woo Baidal 10.1016/j.jpeds.2026.115107 The Journal of Pediatrics (2026) 2026-04-17 The Journal of Pediatrics 2026-04-17 Original Articles https://www.jpeds.com/article/S0022-3476(26)00134-4/fulltext?rss=yes A 10-month-old girl presented with 6 days of unremitting fever accompanied by bilateral conjunctival injection, cracked erythematous lips, plantar edema and erythema, and a diffuse urticarial rash on the trunk and extremities. She had received the Bacille Calmette-Guerin (BCG) vaccination at birth, in the right arm. Within 24 hours of fever onset, the BCG scar became erythematous with papules, induration, and urticarial involvement (Figure). In patients with darker skin tones, these findings may be overlooked but represent an early and important physical sign of Kawasaki disease (KD). BCG Scar Reactivation in Kawasaki Disease Katherine Innis 10.1016/j.jpeds.2026.115106 The Journal of Pediatrics (2026) 2026-04-17 The Journal of Pediatrics 2026-04-17 Rediscovering the Physical Exam https://www.jpeds.com/article/S0022-3476(26)00137-X/fulltext?rss=yes Children with cancer may not have a do not resuscitate (DNR) order, yet absence rarely guarantees cardiopulmonary resuscitation (CPR). In a review of 344 inpatient deaths over a decade, 85% had DNR orders; 20% received CPR, mostly for perceived reversibility. Intensive care unit location and active chemotherapy were associated with fewer DNR orders. Families often declined CPR, despite absence of a DNR order, when death was imminent. The Final Day: What Happens Without a Pre-Existing Do Not Resuscitate Order? Meaghann S. Weaver, Jia Liang, Abagail D. Cohen, Cai Li, Liza-Marie Johnson 10.1016/j.jpeds.2026.115109 The Journal of Pediatrics (2026) 2026-04-16 The Journal of Pediatrics 2026-04-16 Brief Reports https://www.jpeds.com/article/S0022-3476(26)00131-9/fulltext?rss=yes The pursuit of global health equity is frequently hampered by structural barriers that limit the timely and practical dissemination of pediatric research, particularly in low- and middle-income countries (LMICs). Although a vast body of clinically relevant knowledge exists, its impact is often constrained by a triple barrier of interconnected challenges that include economic sustainability, operational complexity, and a structural lack of research tailored to specific local contexts1. Addressing these obstacles requires a coordinated global policy shift grounded in integrated support for accessible science, strengthened governance accountability, and more effective knowledge translation mechanisms. Breaking the Triple Barrier to Equitable and Inclusive Pediatric Research and Innovation Massimo Pettoello-Mantovani, Joseph Haddad, Donjeta Bali, Ida Giardino, Mehmet Vural, Tudor Lucian Pop, Maria Pastore, Eli Somekh 10.1016/j.jpeds.2026.115103 The Journal of Pediatrics (2026) 2026-04-13 The Journal of Pediatrics 2026-04-13 European Paediatric Association https://www.jpeds.com/article/S0022-3476(26)00130-7/fulltext?rss=yes To determine patterns and causes of neonatal deaths in Canadian neonatal intensive care units (NICUs) over the last decade. Trends and Causes of Neonatal Mortality in Canadian Neonatal Intensive Care Units Amelie Stritzke, Harkirat Bhullar, Prakesh S. Shah, Marc Beltempo, Amit Mukerji, Chelsea A. Ruth, Abhay Lodha, Canadian Neonatal Network investigators 10.1016/j.jpeds.2026.115102 The Journal of Pediatrics (2026) 2026-04-10 The Journal of Pediatrics 2026-04-10 Original Articles https://www.jpeds.com/article/S0022-3476(26)00128-9/fulltext?rss=yes We read with great interest the study by Sivakoti et al. examining whether tachycardia-based classification differentiates functional disability among adolescents with chronic orthostatic intolerance1. The comparable Functional Disability Inventory (FDI) scores between postural orthostatic tachycardia syndrome and chronic orthostatic intolerance groups question whether heart rate thresholds meaningfully stratify disease burden. Beyond Heart Rate Thresholds: Reframing Functional Disability in Pediatric Orthostatic Intolerance Anuradha Mokkapati, Rhushvi Thakkar, Anjna Rani, Dinesh Puri 10.1016/j.jpeds.2026.115100 The Journal of Pediatrics (2026) 2026-04-03 The Journal of Pediatrics 2026-04-03 Letters to the Editor https://www.jpeds.com/article/S0022-3476(26)00129-0/fulltext?rss=yes We appreciate the thoughtful comments from Mokkapati et al regarding our recent study examining whether tachycardia or heart rate-based classification differentiate functional disability among adolescents with chronic orthostatic intolerance (COI). The authors raise several important points regarding physiologic phenotyping and potential sources of confounding, and the applicability of the clinically meaningful difference threshold for the Functional Disability Inventory (FDI) in patients with COI. Reply to MS 20260490- “Beyond Heart Rate Thresholds: Reframing Functional Disability in Pediatric Orthostatic Intolerance” Kirti Sivakoti, Corinne Espinoza 10.1016/j.jpeds.2026.115101 The Journal of Pediatrics (2026) 2026-04-02 The Journal of Pediatrics 2026-04-02 Letters to the Editor https://www.jpeds.com/article/S0022-3476(26)00120-4/fulltext?rss=yes To describe trends and variation in testing, treatment, and disposition of febrile infants 61-90 days evaluated in US emergency departments (EDs). Variation in Evaluation and Management of Febrile Infants 61 to 90 Days Old Paul L. Aronson, Prashant Mahajan, Blake Nielsen, Cody S. Olsen, Huong D. Meeks, Robert W. Grundmeier, Nathan Kuppermann, PECARN Registry Working Group 10.1016/j.jpeds.2026.115092 The Journal of Pediatrics (2026) 2026-03-30 The Journal of Pediatrics 2026-03-30 Original Articles https://www.jpeds.com/article/S0022-3476(26)00118-6/fulltext?rss=yes To examine the effect of anemia on mortality among children hospitalized with severe pneumonia in Uganda. The Effect of Anemia on Mortality in Children Hospitalized with Severe Pneumonia in Uganda Peter P. Moschovis, Amal Sharfi, Sumona Chaudhury, Ashley Sharma, Matthew O. Wiens, Elias Kumbakumba, Olive Keneema, Dan Nyehengane, Jerome Kabakyenga, J. Mark Ansermino, Niranjan Kissoon, David C. Christiani, Walter Dzik, Julius P. Kiwanuka, Patricia L. Hibberd 10.1016/j.jpeds.2026.115090 The Journal of Pediatrics (2026) 2026-03-30 The Journal of Pediatrics 2026-03-30 Original Articles https://www.jpeds.com/article/S0022-3476(26)00112-5/fulltext?rss=yes To assess the safety and efficacy of high-dose, oral cholecalciferol supplementation in children and young adults with inflammatory bowel disease (IBD) treated with infliximab or vedolizumab. Efficacy and Safety of Titrated High-Dose Cholecalciferol Supplementation in Children and Young Adult Patients with Inflammatory Bowel Disease Rebecca J. Gordon, Vineet Vishwanath, Ashley Lavoie, Ria Mishra, Paul A. Rufo 10.1016/j.jpeds.2026.115084 The Journal of Pediatrics (2026) 2026-03-30 The Journal of Pediatrics 2026-03-30 Original Articles https://www.jpeds.com/article/S0022-3476(26)00119-8/fulltext?rss=yes To assess the variation in the duration of antibiotic prophylaxis prescribed for patients with asplenia among US pediatric subspecialists. Variability in the Management of Antibiotic Prophylaxis for Patients with Asplenia Kathryn E. Weakley, Marylou M. Dryer, David S. Foley, Kerry K. McGowan, Victoria A. Statler 10.1016/j.jpeds.2026.115091 The Journal of Pediatrics (2026) 2026-03-29 The Journal of Pediatrics 2026-03-29 Original Articles https://www.jpeds.com/article/S0022-3476(26)00116-2/fulltext?rss=yes To compare prehospital and emergency department (ED)-based vital sign assessments for children with out-of-hospital emergencies and to evaluate the relationships between vital signs and mental status assessment on patient mortality or intensive care unit (ICU) admission. Using Vital Signs to Predict Disposition of Children Transported to the Hospital by Emergency Medical Services Sriram Ramgopal, Michelle Macy, Christopher Horvat, Rebecca E. Cash, Masashi Okubo, Stephen Janofsky, Christian Martin-Gill 10.1016/j.jpeds.2026.115088 The Journal of Pediatrics (2026) 2026-03-28 The Journal of Pediatrics 2026-03-28 Original Articles https://www.jpeds.com/article/S0022-3476(26)00115-0/fulltext?rss=yes RetCam® screening for detection of retinopathy of prematurity (ROP) allows for better documentation of digital images, understanding of disease progression, and earlier intervention. We describe the successful implementation of a RetCam® ROP screening program in a large tertiary academic center for 887 exams over a 21-month period.Retinopathy of prematurity (ROP) is a vasoproliferative disorder that affects babies born preterm. It is one of the leading and yet largely preventable causes of childhood blindness worldwide1–3. Implementation of RetCam® Screening in a Large Tertiary Center Elisabeth Kaza, Deborah Vanderveen, Ryan Gise, Carolyn Wu, Elisa Abdulhayoglu, Helen Christou, Elizabeth Y. Flanigan 10.1016/j.jpeds.2026.115087 The Journal of Pediatrics (2026) 2026-03-28 The Journal of Pediatrics 2026-03-28 Brief Reports https://www.jpeds.com/article/S0022-3476(26)00092-2/fulltext?rss=yes I read with interest the paper from Shah et al1 examining the association between probiotic exposure and neurodevelopmental outcomes among infants born extremely preterm in a national, retrospective Canadian cohort. The authors should be commended for addressing an important and clinically relevant topic in neonatal care. Methodological Considerations in Claims of Target Trial Emulation for Probiotic Use in Infants Born Preterm Mohammad Chehrazi 10.1016/j.jpeds.2026.115064 The Journal of Pediatrics (2026) 2026-03-11 The Journal of Pediatrics 2026-03-11 Letters to the Editor https://www.jpeds.com/article/S0022-3476(26)00091-0/fulltext?rss=yes We thank Dr Chehrazi for his comments on our paper on probiotics and neurodevelopmental outcomes.1 We agree with Chehrazi's suggestion of using Hernan and Robbins' guidance on assigning causal inference derived from target trial emulation methodology in form of time zero, immortal time bias, allocation, follow-up, estimand framework, time-varying confounding, and censoring.2 Here, we explain how some of the aspects were considered in our analyses and why some were not applicable in our context. Target Trial Emulation at the Incubator: Where Methods Need to Meet Clinical Care Prakesh S. Shah, Seungwoo Lee 10.1016/j.jpeds.2026.115063 The Journal of Pediatrics (2026) 2026-03-11 The Journal of Pediatrics 2026-03-11 Letters to the Editor https://www.jpeds.com/article/S0022-3476(26)00088-0/fulltext?rss=yes The concept of One Health has emerged as a globally recognized paradigm for addressing complex health challenges that transcend traditional, sectoral boundaries. This integrated and unifying approach is endorsed by leading international and regional organizations, including the World Health Organization, the European Centre for Disease Prevention and Control, the US Centers for Disease Control and Prevention (CDC), and the European Commission. It represents a direct and necessary response to a world in which human health is inextricably linked to animal health and environmental sustainability. The Role of “One Health” in Pediatric Well-Being Massimo Pettoello-Mantovani, Tudor Lucian Pop, Donjeta Bali, Ida Giardino, Angel Carrasco-Sanz, Maria Pastore, Mehmet Vural 10.1016/j.jpeds.2026.115060 The Journal of Pediatrics (2026) 2026-03-07 The Journal of Pediatrics 2026-03-07 European Paediatric Association https://www.jpeds.com/article/S0022-3476(26)00023-5/fulltext?rss=yes Over the past 100 years, physician-scientists have created important new knowledge across the entire spectrum of biomedical inquiry. Increasingly, successful development and application of novel therapies require the engagement of expert investigators from multiple disciplines.1,2 Creation of durable knowledge that enhances human health demands testing at the bedside and in the laboratory. Well-trained physician-scientists are uniquely equipped to pose scientific questions that link biomedical sciences to bedside care. A Pilot Program to Engage, Retain, and Train Physicians as Scientists: Creating and Sustaining a Discovery-Driven Community Tina A. Solvik, Alexandra M. Schnoes, Thi A. Nguyen, Shannon L. Behrman, Elie Maksoud, Sarah S. Goodwin, Ethan J. Weiss, Arun Padmanabhan, David N. Cornfield 10.1016/j.jpeds.2026.114995 The Journal of Pediatrics (2026) 2026-01-19 The Journal of Pediatrics 2026-01-19 Notes from the Association of Medical School Pediatric Department Chairs, Inc https://www.jpeds.com/article/S0022-3476(25)00384-1/fulltext?rss=yes Career pathway decisions in neonatology often are shaped by perceptions of financial disparity between academic and private practice settings. Neonatology, as one of the most labor-intensive and specialized fields in pediatrics, presents a unique economic landscape. Although private practice frequently is assumed to offer significantly greater earnings, academic careers may offer offsetting advantages in leadership opportunities, research and teaching, career stability, and institutional support. Reframing the Financial Divide: A Net Present Value Analysis of Lifetime Earnings in Academic versus Private Practice Neonatology Ankita Shukla, Amna Qasim, Lubaina Ehsan, Vikas Chowdhary, Joshua Daily 10.1016/j.jpeds.2025.114843 The Journal of Pediatrics (2025) 2025-10-08 The Journal of Pediatrics 2025-10-08 Notes from the Association of Medical School Pediatric Department Chairs, Inc