https://www.alzforum.org en https://www.alzforum.org/news/conference-coverage/lipids-lysosomes-and-plaques-how-abca7-nudges-alzheimers-risk Sans ABCA7, cells swell with lipids, lysosomes lose their mojo, and amyloid clearance falters. 10 Apr 2026 20:04:47 EDT https://www.alzforum.org/news/conference-coverage/lipids-lysosomes-and-plaques-how-abca7-nudges-alzheimers-risk#comments https://www.alzforum.org/news/conference-coverage/munch-or-meditate-astrocytes-tell-microglia-what-do When astrocytes secrete MFG-E8, nearby microglia devour neuronal synapses. When astrocytes release Itgb8, microglia freeze up. 10 Apr 2026 16:34:21 EDT https://www.alzforum.org/news/conference-coverage/munch-or-meditate-astrocytes-tell-microglia-what-do#comments https://www.alzforum.org/news/conference-coverage/av-and-tau-whats-their-dance-plaques-dystrophic-neurites At AD/PD 2026, flimsy lipid rafts, growing plaques, and subdued interneurons all take some blame for the rise in p-tau in the Alzheimer’s brain. 10 Apr 2026 12:36:16 EDT https://www.alzforum.org/news/conference-coverage/av-and-tau-whats-their-dance-plaques-dystrophic-neurites#comments https://www.alzforum.org/news/conference-coverage/hunt-biomarkers-rem-sleep-behavior-disorder In Copenhagen, researchers scrutinize RBD for hints of progression to Parkinson’s disease or dementia with Lewy bodies. 08 Apr 2026 12:42:18 EDT https://www.alzforum.org/news/conference-coverage/hunt-biomarkers-rem-sleep-behavior-disorder#comments https://www.alzforum.org/news/conference-coverage/c-brain-workshop-scientists-test-drive-new-ai-agents The consortium is building an "AI co-scientist" to speed discoveries in Alzheimer’s research. 07 Apr 2026 16:23:37 EDT https://www.alzforum.org/news/conference-coverage/c-brain-workshop-scientists-test-drive-new-ai-agents#comments https://www.alzforum.org/news/research-news/hunter-syndrome-brain-shuttle-gains-fda-accelerated-approval By slipping a sulfatase into the brain, Denali’s Avlayah restores lysosomal function and bolsters cognition. 07 Apr 2026 10:15:09 EDT https://www.alzforum.org/news/research-news/hunter-syndrome-brain-shuttle-gains-fda-accelerated-approval#comments https://www.alzforum.org/news/conference-coverage/can-new-strategies-beget-better-tau-immunotherapies An in-vivo propagation model identifies a more potent anti-tau antibody. A different bi-specific antibody to the C-terminal blocks tau seeding. 03 Apr 2026 18:10:05 EDT https://www.alzforum.org/news/conference-coverage/can-new-strategies-beget-better-tau-immunotherapies#comments https://www.alzforum.org/news/conference-coverage/lewy-bodies-blunt-amyloid-immunotherapy-trial-measure-how-much AD/PD 2026 offered the first data on less gantenerumab benefit in the presence of α-synuclein pathology. A new donanemab trial will investigate further. 03 Apr 2026 12:00:17 EDT https://www.alzforum.org/news/conference-coverage/lewy-bodies-blunt-amyloid-immunotherapy-trial-measure-how-much#comments https://www.alzforum.org/news/conference-coverage/does-synuclein-immunotherapy-slow-parkinsons-after-all Phase 2 OLE data hints that prasinezumab halved the rate of decline in people who also took symptomatic drugs. Phase 3 has started. 03 Apr 2026 11:53:17 EDT https://www.alzforum.org/news/conference-coverage/does-synuclein-immunotherapy-slow-parkinsons-after-all#comments https://www.alzforum.org/news/conference-coverage/old-cholinergic-drug-gets-new-chance-phase-2 Following promising tolerability data, a compound targeting acetylcholine receptors is once again in clinical trials for Alzheimer’s disease. 02 Apr 2026 10:52:39 EDT https://www.alzforum.org/news/conference-coverage/old-cholinergic-drug-gets-new-chance-phase-2#comments https://www.alzforum.org/news/conference-coverage/adding-emtbr-tau243-p-tau217-sharpens-ad-diagnosis Among people who are cognitively impaired, plasma p-tau217 frequently misdiagnoses Alzheimer’s disease. Adding eMTBR-tau243 helps with that. 01 Apr 2026 21:47:15 EDT https://www.alzforum.org/news/conference-coverage/adding-emtbr-tau243-p-tau217-sharpens-ad-diagnosis#comments https://www.alzforum.org/news/conference-coverage/posdinemab-epitaph-p-tau217-tanked-dementia-marched The tau antibody was unable to slow cognitive decline or accumulation of new tangles, yet it completely ablated p-tau217 in CSF. 01 Apr 2026 12:42:14 EDT https://www.alzforum.org/news/conference-coverage/posdinemab-epitaph-p-tau217-tanked-dementia-marched#comments https://www.alzforum.org/news/conference-coverage/new-crop-synuclein-tracers-enter-human-testing At AD/PD, researchers presented early PET imaging studies in people with different synucleinopathies. 28 Mar 2026 16:13:30 EDT https://www.alzforum.org/news/conference-coverage/new-crop-synuclein-tracers-enter-human-testing#comments https://www.alzforum.org/news/conference-coverage/henrik-zetterbergs-mantra-heterogeneity-heterogeneity-heterogeneity In Copenhagen, Henrik Zetterberg expounds on the next areas of focus in ADRD biomarker research and development. 28 Mar 2026 10:55:09 EDT https://www.alzforum.org/news/conference-coverage/henrik-zetterbergs-mantra-heterogeneity-heterogeneity-heterogeneity#comments https://www.alzforum.org/news/conference-coverage/nlrp3-inhibitor-passes-muster-early-parkinsons-trial Anti-inflammasome drug appears safe, hits its intended target, and may help people move a little more easily. 27 Mar 2026 21:07:22 EDT https://www.alzforum.org/news/conference-coverage/nlrp3-inhibitor-passes-muster-early-parkinsons-trial#comments https://www.alzforum.org/news/conference-coverage/ai-ad-developers-throw-their-hats-ring At AD/PD in Copenhagen, AI scientists competed for two $1 million prizes to develop products for AD research. 27 Mar 2026 20:47:21 EDT https://www.alzforum.org/news/conference-coverage/ai-ad-developers-throw-their-hats-ring#comments https://www.alzforum.org/news/conference-coverage/big-picture-three-inflection-points-mark-amyloid-cascade In a plenary at AD/PD, Bart De Strooper offered a vision of successive cellular struggles in Alzheimer’s pathophysiology, with key moments for therapeutic intervention. 27 Mar 2026 15:50:13 EDT https://www.alzforum.org/news/conference-coverage/big-picture-three-inflection-points-mark-amyloid-cascade#comments https://www.alzforum.org/news/research-news/can-synaptic-markers-forecast-worsening-alzheimers-disease In Chinese and European cohorts, neuronal pentraxin-1 NPTX1 and neuronal pentraxin receptor NPTXR predicted neurodegeneration. 19 Mar 2026 16:52:32 EDT https://www.alzforum.org/news/research-news/can-synaptic-markers-forecast-worsening-alzheimers-disease#comments https://www.alzforum.org/news/research-news/microglial-proteins-csf-point-shifting-strategies-ad-worsens According to CSF proteomics, microglia changed from mobilized to dysregulated states as Alzheimer’s disease advanced. 19 Mar 2026 15:19:35 EDT https://www.alzforum.org/news/research-news/microglial-proteins-csf-point-shifting-strategies-ad-worsens#comments https://www.alzforum.org/news/research-news/does-tau-mess-oligodendrocyte-gene-methylation An epigenome-wide scan of Alzheimer’s brains links phospho- and soluble tau to methylation of oligodendrocyte genes. 19 Mar 2026 12:17:14 EDT https://www.alzforum.org/news/research-news/does-tau-mess-oligodendrocyte-gene-methylation#comments https://www.alzforum.org/news/research-news/elevated-blood-p-tau181-p-tau217-not-unique-alzheimers-disease In systemic amyloidoses, blood p-tau markers were as high as in people with AD, suggesting caution when interpreting test results 13 Mar 2026 16:34:29 EDT https://www.alzforum.org/news/research-news/elevated-blood-p-tau181-p-tau217-not-unique-alzheimers-disease#comments https://www.alzforum.org/news/research-news/meet-tanycytes-bridging-brain-and-body-these-cells-may-dispose-tau Specialized ependymal cells in the third ventricle ferry hormones from blood to cerebrospinal fluid. New research suggests they also transport tau from brain to blood. 13 Mar 2026 13:29:10 EDT https://www.alzforum.org/news/research-news/meet-tanycytes-bridging-brain-and-body-these-cells-may-dispose-tau#comments https://www.alzforum.org/news/research-news/golga8-new-ftld-fet-gene-dinucleotide-expansion GWAS finds that most people with aFTLD-U, a subtype of FTLD-FET, carry a CT expansion in the GOLGA8 locus. 12 Mar 2026 16:43:55 EDT https://www.alzforum.org/news/research-news/golga8-new-ftld-fet-gene-dinucleotide-expansion#comments https://www.alzforum.org/news/research-news/ribonuclease-k-prolongs-life-chomping-circular-rnas Without the nuclease, the RNAs pile up in stress granules, gumming up RNA and protein homeostasis. 12 Mar 2026 16:13:48 EDT https://www.alzforum.org/news/research-news/ribonuclease-k-prolongs-life-chomping-circular-rnas#comments https://www.alzforum.org/news/research-news/car-astrocyte-therapy-alzheimers-disease In an AD mouse model, chimeric antigen receptors turn astrocytes into amyloid-eating machines, lowering plaques and reshaping brain immunity. 12 Mar 2026 14:21:19 EDT https://www.alzforum.org/news/research-news/car-astrocyte-therapy-alzheimers-disease#comments https://www.alzforum.org/news/research-news/ad-neurogenesis-stalls-superagers-it-ramps Neurogenesis is regulated by epigenetic changes. In Alzheimer’s disease, these changes inhibit formation of new cells; in superagers, they turn on resilience genes that promote neuron formation. 06 Mar 2026 15:52:42 EST https://www.alzforum.org/news/research-news/ad-neurogenesis-stalls-superagers-it-ramps#comments https://www.alzforum.org/news/research-news/when-loaded-granulovacuolar-bodies-neurons-combat-tau Long thought a marker for diseased neurons, GVBs may be a sign that the cells have switched on a proteostasis program that counters tauopathy. 06 Mar 2026 14:03:00 EST https://www.alzforum.org/news/research-news/when-loaded-granulovacuolar-bodies-neurons-combat-tau#comments https://www.alzforum.org/news/research-news/could-tau-explain-link-between-pneumonia-and-dementia In mice, a bacterial infection in the lungs instigated leakage of the blood-brain barrier and glial reactivity in the brain. This was all dependent on tau. 05 Mar 2026 13:38:21 EST https://www.alzforum.org/news/research-news/could-tau-explain-link-between-pneumonia-and-dementia#comments https://www.alzforum.org/news/research-news/lithium-trial-misses-cognitive-endpoints Lithium carbonate did not benefit people with mild cognitive impairment, but follow up testing seems feasible. 05 Mar 2026 11:43:24 EST https://www.alzforum.org/news/research-news/lithium-trial-misses-cognitive-endpoints#comments https://www.alzforum.org/news/research-news/proteomics-nets-new-markers-cerebrovascular-disease Proteins in the cerebrospinal fluid might predict cognitive decline and stroke. 04 Mar 2026 10:22:37 EST https://www.alzforum.org/news/research-news/proteomics-nets-new-markers-cerebrovascular-disease#comments