https://www.alzforum.org en https://www.alzforum.org/news/research-news/even-midlife-alzheimers-biomarkers-blood-spell-trouble In a community cohort, people who were biomarker-positive did worse on tests of processing speed and executive function, and they declined faster on cognitive tests. 05 Jun 2026 07:51:55 EDT https://www.alzforum.org/news/research-news/even-midlife-alzheimers-biomarkers-blood-spell-trouble#comments https://www.alzforum.org/news/research-news/neuroproteasomes-chew-tau-it-tangles Blocking specialized proteasomes in the neuronal cell membrane triggers rapid tau aggregation. ApoE4 depletes these specialized proteasomes from the plasma membrane. 04 Jun 2026 11:15:22 EDT https://www.alzforum.org/news/research-news/neuroproteasomes-chew-tau-it-tangles#comments https://www.alzforum.org/news/research-news/synapses-suffer-when-splicing-goes-awry-tdp-43-proteinopathy Suppressing mis-splicing of four transcripts rescued synaptic transmission in induced human neurons. 03 Jun 2026 15:16:12 EDT https://www.alzforum.org/news/research-news/synapses-suffer-when-splicing-goes-awry-tdp-43-proteinopathy#comments https://www.alzforum.org/news/research-news/staging-alzheimers-now-blood-tests Together, plasma p-tau217 and eMTBR-tau243 can accurately predict a person’s brain pathology as per PET. 30 May 2026 06:17:12 EDT https://www.alzforum.org/news/research-news/staging-alzheimers-now-blood-tests#comments https://www.alzforum.org/news/research-news/fibrils-tubulin-polymerization-protein-distinguish-msa-parkinsons TPPP twists into amyloid fibrils. An assay that amplifies them distinguishes multiple system atrophy from other neurological disorders. 29 May 2026 14:43:04 EDT https://www.alzforum.org/news/research-news/fibrils-tubulin-polymerization-protein-distinguish-msa-parkinsons#comments https://www.alzforum.org/news/research-news/brain-waste-please-proceed-your-nearest-exit A new mouse model shows neuronal proteins drain from the parenchyma through a variety of routes. 29 May 2026 12:15:19 EDT https://www.alzforum.org/news/research-news/brain-waste-please-proceed-your-nearest-exit#comments https://www.alzforum.org/news/conference-coverage/tau-fibrils-ensnare-rna-binding-protein-pinin-derailing-splicing Tau fibrils from different tauopathies sequester Pinin. Is this a general mechanism underlying tau toxicity? 29 May 2026 12:05:38 EDT https://www.alzforum.org/news/conference-coverage/tau-fibrils-ensnare-rna-binding-protein-pinin-derailing-splicing#comments https://www.alzforum.org/news/conference-coverage/one-tau-structure-one-disease-if-only-it-were-simple A distinct tau filament structure was identified in an S305I-tau mutation carrier, who had pathology akin to argyrophilic grain disease. It differed from structures found in sporadic disease. 23 May 2026 08:41:39 EDT https://www.alzforum.org/news/conference-coverage/one-tau-structure-one-disease-if-only-it-were-simple#comments https://www.alzforum.org/news/research-news/pi-2620-tracks-tau-changes-psp-ready-trials The PET tracer tracks tau buildup in progressive supranuclear palsy. Some think it could help drug development; others remain unconvinced. 23 May 2026 08:40:37 EDT https://www.alzforum.org/news/research-news/pi-2620-tracks-tau-changes-psp-ready-trials#comments https://www.alzforum.org/news/conference-coverage/two-new-tau-therapies-move-phase-3-psp-trials At the Tau Global conference, speakers showcased progress in an antisense oligonucleotide and a small-molecule p75 modulator. Other strategies also look promising. 23 May 2026 08:37:48 EDT https://www.alzforum.org/news/conference-coverage/two-new-tau-therapies-move-phase-3-psp-trials#comments https://www.alzforum.org/news/research-news/denali-biogen-halt-lrrk2-luma-parkinsons-trial The LRRK2 inhibitor DNL151/BIIB122 did not slow disease progression. Trial in familial PD to continue. 22 May 2026 15:16:17 EDT https://www.alzforum.org/news/research-news/denali-biogen-halt-lrrk2-luma-parkinsons-trial#comments https://www.alzforum.org/news/research-news/blocking-molecular-switch-keeps-microglia-working-after-stroke A transcription factor turned off microglial repair after a stroke. An antisense oligonucleotide turned it back on. Could this work for Alzheimer’s? 22 May 2026 14:09:28 EDT https://www.alzforum.org/news/research-news/blocking-molecular-switch-keeps-microglia-working-after-stroke#comments https://www.alzforum.org/news/research-news/plaque-removal-surrogate-statisticians-say-not-so-fast A new statistical analysis finds methodological flaws in a recent publication that linked plaque removal to cognitive benefit in the donanemab Phase 3 trial. 18 May 2026 11:08:11 EDT https://www.alzforum.org/news/research-news/plaque-removal-surrogate-statisticians-say-not-so-fast#comments https://www.alzforum.org/news/research-news/if-too-much-s-acylation-bad-too-little-may-be-well For some brain proteins, lingering lipid tags drive lipofuscin formation and neuronal overgrowth. For TDP-43, the same modification prevents aggregation. 15 May 2026 16:31:53 EDT https://www.alzforum.org/news/research-news/if-too-much-s-acylation-bad-too-little-may-be-well#comments https://www.alzforum.org/news/research-news/can-good-apoe-liver-offset-bad-apoe-brain When ApoE4 mice express ApoE3 Christchurch in hepatocytes, they have less amyloid pathology in the brain. 14 May 2026 16:58:57 EDT https://www.alzforum.org/news/research-news/can-good-apoe-liver-offset-bad-apoe-brain#comments https://www.alzforum.org/news/research-news/astrocyte-atlas-shows-transcription-factors-might-slow-alzheimers By overexpressing a library of transcription factors in the mouse brain, scientists pinpointed master regulators of different astrocyte functions and states. 14 May 2026 15:17:17 EDT https://www.alzforum.org/news/research-news/astrocyte-atlas-shows-transcription-factors-might-slow-alzheimers#comments https://www.alzforum.org/news/research-news/tdp-43-aggregates-breaking-no-longer-hard-do A short RNA chaperone stabilized TDP-43, preventing its aggregation and even breaking up existing inclusions in cultured cells and in mouse brain. 13 May 2026 16:17:49 EDT https://www.alzforum.org/news/research-news/tdp-43-aggregates-breaking-no-longer-hard-do#comments https://www.alzforum.org/news/community-news/philanthropy-funnels-261-million-parkinsons-research Thirty-two teams of investigators will receive funding as Aligning Science Across Parkinson’s expands its research network. 08 May 2026 21:02:22 EDT https://www.alzforum.org/news/community-news/philanthropy-funnels-261-million-parkinsons-research#comments https://www.alzforum.org/news/research-news/astrocytes-downs-reactive-early-life-exhausted-near-end In infants with DS, astrocytes were activated. Later in life, the cells were shut down, particularly among those who also had Alzheimer’s pathology. 08 May 2026 17:41:17 EDT https://www.alzforum.org/news/research-news/astrocytes-downs-reactive-early-life-exhausted-near-end#comments https://www.alzforum.org/news/research-news/fda-delays-decision-subcutaneous-leqembi-starting-dose The agency pushed its decision date from May 24 to Aug 24 after requesting more information from drugmakers Biogen and Eisai. 08 May 2026 16:27:48 EDT https://www.alzforum.org/news/research-news/fda-delays-decision-subcutaneous-leqembi-starting-dose#comments https://www.alzforum.org/news/conference-coverage/microglia-must-have-plaque-clearance-amyloid-immunotherapy Amyloid antibodies unable to engage microglia had no effect on plaque in mice or in postmortem Alzheimer’s brain sections. 07 May 2026 15:25:15 EDT https://www.alzforum.org/news/conference-coverage/microglia-must-have-plaque-clearance-amyloid-immunotherapy#comments https://www.alzforum.org/news/research-news/lipofuscin-ingredients-tie-development-degeneration Proteogenomics shows that, of CSF proteins associated with neurodegeneration, only a third turned up in blood, and their links to disease were weaker. 07 May 2026 13:47:23 EDT https://www.alzforum.org/news/research-news/lipofuscin-ingredients-tie-development-degeneration#comments https://www.alzforum.org/news/research-news/looking-new-disease-markers-try-csf-not-plasma Proteogenomics shows that, of CSF proteins that associated with neurodegeneration, only a third turned up in blood, and their links to disease were weaker. 05 May 2026 14:57:47 EDT https://www.alzforum.org/news/research-news/looking-new-disease-markers-try-csf-not-plasma#comments https://www.alzforum.org/news/research-news/fecal-fingerprint-sorts-may-foretell-parkinsons Metagenomics identified microbiome changes in people with PD. Healthy carriers of pathogenic GBA1 mutations have a similar signature. 01 May 2026 18:32:08 EDT https://www.alzforum.org/news/research-news/fecal-fingerprint-sorts-may-foretell-parkinsons#comments https://www.alzforum.org/news/research-news/somatic-mutations-surface-alzheimers-and-related-diseases One in 50 people with sporadic ALS/FTD has mutations causing the diseases’ familial forms in brain cells. In sporadic AD, somatic mutations may drive inflammation. 01 May 2026 12:39:08 EDT https://www.alzforum.org/news/research-news/somatic-mutations-surface-alzheimers-and-related-diseases#comments https://www.alzforum.org/news/research-news/deadly-duo-ftd-variants-gang-stab-lysosomes In the brains of progranulin mutation carriers, growing TMEM106B fibrils burst through lysosome membranes. 30 Apr 2026 12:17:02 EDT https://www.alzforum.org/news/research-news/deadly-duo-ftd-variants-gang-stab-lysosomes#comments https://www.alzforum.org/news/conference-coverage/homing-arias-cellular-villains-macrophages-fibroblasts Both cell types hack away at the extracellular matrix, both damage blood vessels during amyloid immunotherapy. 29 Apr 2026 16:39:07 EDT https://www.alzforum.org/news/conference-coverage/homing-arias-cellular-villains-macrophages-fibroblasts#comments https://www.alzforum.org/news/conference-coverage/could-blocking-complement-cascade-ward-aria In mice, keeping C1q from binding amyloid antibodies slashed microhemorrhages and preserved blood vessels. Plaque clearance continued unabated. 29 Apr 2026 13:21:08 EDT https://www.alzforum.org/news/conference-coverage/could-blocking-complement-cascade-ward-aria#comments https://www.alzforum.org/news/research-news/gap-junctions-link-brain-wide-astrocyte-networks By communicating through billions of gap junctions, astrocytes form functional networks across brain regions. 28 Apr 2026 13:11:47 EDT https://www.alzforum.org/news/research-news/gap-junctions-link-brain-wide-astrocyte-networks#comments https://www.alzforum.org/news/research-news/inside-job-antibody-flags-toxic-tau-disposal-lysosome A mini antibody recruits the cell's autophagy machinery to dissolve tau tangles in neurons. 24 Apr 2026 14:14:24 EDT https://www.alzforum.org/news/research-news/inside-job-antibody-flags-toxic-tau-disposal-lysosome#comments