https://www.alzforum.org en https://www.alzforum.org/news/research-news/aphid-infests-lysosomes-living-brain-illuminating-their-ph Acid pH Indicator Dye, a custom fluorescent probe, revealed that most meningeal macrophages have weakly acidified lysosomes. Upon injury, the organelles lower their pH. 09 Oct 2026 15:11:15 EDT https://www.alzforum.org/news/research-news/aphid-infests-lysosomes-living-brain-illuminating-their-ph#comments https://www.alzforum.org/news/research-news/could-alternative-polyadenylation-explain-some-gwas-hits Scientists linked 168 GWAS loci for 17 brain disorders to variants that altered polyA tails. One such variant sent α-synuclein into neurites and hiked Parkinson’s risk. 09 Oct 2026 10:48:21 EDT https://www.alzforum.org/news/research-news/could-alternative-polyadenylation-explain-some-gwas-hits#comments https://www.alzforum.org/news/research-news/genotyping-surprise-new-tau-haplotype-carries-unexpected-marker An H1 sub-haplotype discovered in African-ancestry iPSC lines contains a single-nucleotide polymorphism commonly used to identify H2. 08 Oct 2026 16:03:54 EDT https://www.alzforum.org/news/research-news/genotyping-surprise-new-tau-haplotype-carries-unexpected-marker#comments https://www.alzforum.org/news/research-news/using-ai-catch-aria-experts-weigh-pros-and-cons Neuroradiologists and Alzheimer’s clinicians agree that AI may improve detection. Some want more research on the value for patients. 07 Oct 2026 13:42:30 EDT https://www.alzforum.org/news/research-news/using-ai-catch-aria-experts-weigh-pros-and-cons#comments https://www.alzforum.org/news/research-news/old-drug-new-tricks-guanabenz-shows-signal-white-matter-disease In a Phase 1/2 trial, a blood pressure medication appeared to preserve children’s ability to walk, and lowered blood NfL. Does it target the integrated stress response? 07 Oct 2026 10:18:08 EDT https://www.alzforum.org/news/research-news/old-drug-new-tricks-guanabenz-shows-signal-white-matter-disease#comments https://www.alzforum.org/news/research-news/man-mouse-tau-strains-stay-true-structure Tau aggregates isolated from human AD or CBD brains seeded mouse tau to morph into fibrils matching their shape. Proof of prion-like templated misfolding? 01 Oct 2026 19:47:48 EDT https://www.alzforum.org/news/research-news/man-mouse-tau-strains-stay-true-structure#comments https://www.alzforum.org/news/research-news/new-twist-cryptic-rnas-they-come-circles Two groups found that TDP-43 loss creates stable, cryptic, circular RNAs. They could be biomarkers. A third reported that blocking cryptic UNC13A spares memory. 01 Oct 2026 16:27:19 EDT https://www.alzforum.org/news/research-news/new-twist-cryptic-rnas-they-come-circles#comments https://www.alzforum.org/news/research-news/apoe4-carriers-fibronectin-disturbs-blood-brain-barrier Too much fibronectin suppresses growth factor signaling between astrocytes and endothelial cells at this border zone. 25 Sep 2026 19:13:05 EDT https://www.alzforum.org/news/research-news/apoe4-carriers-fibronectin-disturbs-blood-brain-barrier#comments https://www.alzforum.org/news/research-news/apoe4-transforms-pericytes-trapping-amyloid-blood-vessels In postmortem brain and organoids, the Alzheimer’s risk allele turns pericytes into fibronectin-secreting myofibroblasts. 25 Sep 2026 18:50:55 EDT https://www.alzforum.org/news/research-news/apoe4-transforms-pericytes-trapping-amyloid-blood-vessels#comments https://www.alzforum.org/news/research-news/brain-biopsies-deliver-biochemistry-bonanza In a tiny piece of cortex from people undergoing shunt surgery, scientists measure Aβ and tau peptides, gauge a plaque’s age, and track newly minted tau. 25 Sep 2026 17:33:05 EDT https://www.alzforum.org/news/research-news/brain-biopsies-deliver-biochemistry-bonanza#comments https://www.alzforum.org/news/research-news/lecanemab-tells-brain-immune-cells-call-support-periphery In mice on amyloid immunotherapy, border-associated macrophages in the brain recruit monocytes and T cells from the blood. Does this spur ARIA? 24 Sep 2026 16:26:57 EDT https://www.alzforum.org/news/research-news/lecanemab-tells-brain-immune-cells-call-support-periphery#comments https://www.alzforum.org/news/research-news/bespoke-aso-slows-disease-one-man-rare-form-als Over one year of treatment with a CHCH10-targeted ASO, neurofilament light dipped into the normal range, and clinical symptoms stabilized or improved ever so slightly. 24 Sep 2026 15:15:19 EDT https://www.alzforum.org/news/research-news/bespoke-aso-slows-disease-one-man-rare-form-als#comments https://www.alzforum.org/news/research-news/hormone-replacement-therapy-when-it-good-brain New studies suggest that HRT might hedge dementia risk. They add to a sea of conflicting literature. 23 Sep 2026 15:15:39 EDT https://www.alzforum.org/news/research-news/hormone-replacement-therapy-when-it-good-brain#comments https://www.alzforum.org/news/research-news/human-organoids-refill-hollowed-out-mouse-brain Three-dimensional iPSC cultures grafted into genetically depleted mouse cortex form connections with host circuits. 18 Sep 2026 19:57:29 EDT https://www.alzforum.org/news/research-news/human-organoids-refill-hollowed-out-mouse-brain#comments https://www.alzforum.org/news/research-news/gwas-nets-genes-alter-apoe4-risk A stratified genome-wide meta-analysis picks out four loci that affect Alzheimer’s risk differently in APOE4 versus APOE3 carriers. 18 Sep 2026 18:05:18 EDT https://www.alzforum.org/news/research-news/gwas-nets-genes-alter-apoe4-risk#comments https://www.alzforum.org/news/research-news/flying-under-radar-microproteins-may-contribute-alzheimers A new atlas of small proteins in the frontal cortex shows that many change abundance in AD, including one that fatigues microglia. 18 Sep 2026 15:37:08 EDT https://www.alzforum.org/news/research-news/flying-under-radar-microproteins-may-contribute-alzheimers#comments https://www.alzforum.org/news/research-news/molecule-molecule-new-tech-maps-taus-many-forms By measuring tau proteoforms on single molecules, scientists see how splicing and phosphorylation combine. This works in Alzheimer’s tissue. P-tau217 happens late. 17 Sep 2026 07:54:38 EDT https://www.alzforum.org/news/research-news/molecule-molecule-new-tech-maps-taus-many-forms#comments https://www.alzforum.org/news/research-news/nagging-pain-av42-accumulation-could-be-blame-scientists-claim In response to a paw injury, neurons in mouse spinal cord cranked out Aβ42, which set off a cycle of chronic pain. 15 Sep 2026 21:02:58 EDT https://www.alzforum.org/news/research-news/nagging-pain-av42-accumulation-could-be-blame-scientists-claim#comments https://www.alzforum.org/news/research-news/polyubiquitin-may-dictate-structure-tau-fibrils When scientists tweaked the posttranslational modification, the fibrils' cores shape-shifted. 11 Sep 2026 16:58:23 EDT https://www.alzforum.org/news/research-news/polyubiquitin-may-dictate-structure-tau-fibrils#comments https://www.alzforum.org/news/research-news/can-alzheimers-mess-bone-marrow-monocytes In AD mouse models monocyte development stalls, and few get into the brain. Blocking interferon signaling restored monocytes and slowed hippocampal neurodegeneration. 11 Sep 2026 09:01:10 EDT https://www.alzforum.org/news/research-news/can-alzheimers-mess-bone-marrow-monocytes#comments https://www.alzforum.org/news/research-news/delivered-vesicle-antibody-tamps-down-tau-tdp-43 Pathologic deposits fade in cultured neurons and mouse brain treated with antibodies that are fused to autophagosome protein LC3. 10 Sep 2026 15:09:04 EDT https://www.alzforum.org/news/research-news/delivered-vesicle-antibody-tamps-down-tau-tdp-43#comments https://www.alzforum.org/news/research-news/can-peripheral-antigen-presenting-cells-hasten-tauopathies Immune dendritic cells prime CD8 T cells to exacerbate neurodegeneration in tauopathy mice. 04 Sep 2026 18:56:00 EDT https://www.alzforum.org/news/research-news/can-peripheral-antigen-presenting-cells-hasten-tauopathies#comments https://www.alzforum.org/news/research-news/apoe4-astrocytes-stoke-synuclein-pathology-brain-organoids In organoids made of six major brain-cell types, cholesterol-laden APOE4 astrocytes fuel accumulation of phosphorylated α-synuclein in neurons. 04 Sep 2026 15:22:42 EDT https://www.alzforum.org/news/research-news/apoe4-astrocytes-stoke-synuclein-pathology-brain-organoids#comments https://www.alzforum.org/news/research-news/does-rogue-receptor-drive-synapse-loss-early-alzheimers-disease In mice, amyloid triggered the expression of ERBB4 in excitatory neurons. Switching off the receptor curbed synapse loss, limited plaque buildup, and restored memory. 02 Sep 2026 16:20:49 EDT https://www.alzforum.org/news/research-news/does-rogue-receptor-drive-synapse-loss-early-alzheimers-disease#comments https://www.alzforum.org/news/research-news/too-much-myelin-bad-brain In postmortem corpus callosum from people with age-related cognitive decline, myelin was thicker and looser, axons smaller, and oligodendrocytes abundant. 02 Sep 2026 11:33:31 EDT https://www.alzforum.org/news/research-news/too-much-myelin-bad-brain#comments https://www.alzforum.org/news/research-news/fda-clears-c2ns-precivity-ad2-and-roches-elecsys-p-tau217-tests Roche’s is the first stand-alone p-tau217 test to win the seal of approval. 28 Aug 2026 20:03:17 EDT https://www.alzforum.org/news/research-news/fda-clears-c2ns-precivity-ad2-and-roches-elecsys-p-tau217-tests#comments https://www.alzforum.org/news/research-news/new-alzheimers-variant-may-help-scarf-down-amyloid Exome study uncovers protective chromosome 22 duplication that modifies AD risk. 28 Aug 2026 15:58:16 EDT https://www.alzforum.org/news/research-news/new-alzheimers-variant-may-help-scarf-down-amyloid#comments https://www.alzforum.org/news/research-news/apoe-shapes-proteome-astrocyte-lipid-droplets In iPSC-derived astrocytes, the protein composition and turnover rate of lipid droplets differ by APOE genotype. 28 Aug 2026 13:01:34 EDT https://www.alzforum.org/news/research-news/apoe-shapes-proteome-astrocyte-lipid-droplets#comments https://www.alzforum.org/news/research-news/brain-ages-infiltrating-monocytes-replace-native-microglia Using mutations and epigenetics to track cellular origins, two studies report human microglia shift from yolk-sac-derived to monocyte-derived starting about age 50. 27 Aug 2026 18:02:52 EDT https://www.alzforum.org/news/research-news/brain-ages-infiltrating-monocytes-replace-native-microglia#comments https://www.alzforum.org/news/research-news/meet-mitochondrial-plaque-new-alzheimers-pathology In amyloid mice and postmortem human AD brain, mitochondria-packed dystrophic neurites appear to cluster into large, “plaque-like” structures. 26 Aug 2026 12:21:39 EDT https://www.alzforum.org/news/research-news/meet-mitochondrial-plaque-new-alzheimers-pathology#comments