https://www.alzforum.org en https://www.alzforum.org/news/research-news/minus-tdp-43-microglia-fumble-myelin-cleanup Depleting TDP-43 in microglia causes the TREM2 partner Tyrobp to pick up a cryptic exon, hobbling signals managing myelin. 16 Jul 2026 14:07:05 EDT https://www.alzforum.org/news/research-news/minus-tdp-43-microglia-fumble-myelin-cleanup#comments https://www.alzforum.org/news/research-news/massive-meta-analysis-pegs-centiloid-positivity-thresholds Data from 50,000 people centered 18 centiloids as the best single cutoff, 11 and 26 as the best double cutoffs. 16 Jul 2026 11:05:13 EDT https://www.alzforum.org/news/research-news/massive-meta-analysis-pegs-centiloid-positivity-thresholds#comments https://www.alzforum.org/news/research-news/does-apoe4-act-through-oligodendrocytes Both X-linked and cell-type GWAS suggest that APOE4 perturbs myelination, particularly in women, offering a clue to their higher AD risk. 11 Jul 2026 07:15:21 EDT https://www.alzforum.org/news/research-news/does-apoe4-act-through-oligodendrocytes#comments https://www.alzforum.org/news/research-news/immune-shocker-mouse-brain-b-cells-drive-synaptic-pruning Frenzied neuronal activity recruits B cells. IgMs combine with complement to mark synapses for pruning. In an AD model, dampening neuronal firing stymies synaptic loss. 09 Jul 2026 18:12:03 EDT https://www.alzforum.org/news/research-news/immune-shocker-mouse-brain-b-cells-drive-synaptic-pruning#comments https://www.alzforum.org/news/research-news/succumbing-als-neurons-descend-disease-state As disease worsens, alpha motor neurons increasingly transition into a newly identified state, featuring a mix of protective and degenerative signals. 09 Jul 2026 15:48:31 EDT https://www.alzforum.org/news/research-news/succumbing-als-neurons-descend-disease-state#comments https://www.alzforum.org/news/research-news/proteome-wide-association-study-points-new-alzheimers-genes Plasma PWAS identifies 18 AD risk genes that regulate abundance of proteins in plasma. Three are new. 05 Jul 2026 10:49:45 EDT https://www.alzforum.org/news/research-news/proteome-wide-association-study-points-new-alzheimers-genes#comments https://www.alzforum.org/news/research-news/rare-variants-offer-clues-apoe-toxicity-lipidation-aggregation A new protective variant, W276C, lowers ApoE’s propensity to aggregate, while risk variant R189C boosts its lipidation, messing up microglial metabolism. 02 Jul 2026 18:06:19 EDT https://www.alzforum.org/news/research-news/rare-variants-offer-clues-apoe-toxicity-lipidation-aggregation#comments https://www.alzforum.org/news/research-news/membrane-fix-flat-ftd-proteins-patch-cell-surface Annexin-A11 forms a temporary plug, then the ESCRT-III complex pinches it off to finish the repair. 02 Jul 2026 11:49:58 EDT https://www.alzforum.org/news/research-news/membrane-fix-flat-ftd-proteins-patch-cell-surface#comments https://www.alzforum.org/news/research-news/low-csf-tmem106b-sign-disease-or-just-good-genes People with frontotemporal dementia or Alzheimer’s disease have less TMEM106B in their cerebrospinal fluid. But so do people who carry a protective variant. 01 Jul 2026 18:09:54 EDT https://www.alzforum.org/news/research-news/low-csf-tmem106b-sign-disease-or-just-good-genes#comments https://www.alzforum.org/news/research-news/amyloid-stokes-toxic-mrna-mitochondria-and-inflammation-flares Under healthy conditions, neurons degrade mitochondrial mRNA that leaks into the cytosol. Not when amyloid is around. 26 Jun 2026 16:28:07 EDT https://www.alzforum.org/news/research-news/amyloid-stokes-toxic-mrna-mitochondria-and-inflammation-flares#comments https://www.alzforum.org/news/research-news/plasma-proteome-offers-clues-risk-and-resilience-apoe4-carriers APOE2 and APOE4 carriers have distinct profiles that are not simple opposites. APOE4 carriers who keep their memories sharp express protective genes. 26 Jun 2026 12:37:14 EDT https://www.alzforum.org/news/research-news/plasma-proteome-offers-clues-risk-and-resilience-apoe4-carriers#comments https://www.alzforum.org/news/research-news/does-apoe4-prematurely-age-astrocytes Protein markers in blood suggest ApoE4 accelerates astrocyte aging. People with astrocytes older than their calendar age are more likely to get Alzheimer's. 25 Jun 2026 17:48:19 EDT https://www.alzforum.org/news/research-news/does-apoe4-prematurely-age-astrocytes#comments https://www.alzforum.org/news/conference-coverage/mjff-gathers-scientists-advance-synuclein-tracer-development Seven Michael J. Fox Foundation–funded groups are developing PET tracers for synucleinopathies. PPMI is gearing up to test the most promising. 24 Jun 2026 16:06:38 EDT https://www.alzforum.org/news/conference-coverage/mjff-gathers-scientists-advance-synuclein-tracer-development#comments https://www.alzforum.org/news/research-news/sickly-sweet-sugary-proteins-abound-ad-brain-may-worsen-dementia In mouse models, curbing glycosylation improved memory, boosting it worsened memory. Alzheimer’s patients who take glucosamine declined faster. 19 Jun 2026 12:43:13 EDT https://www.alzforum.org/news/research-news/sickly-sweet-sugary-proteins-abound-ad-brain-may-worsen-dementia#comments https://www.alzforum.org/news/research-news/tapping-jugular-boosts-alzheimers-biomarker-performance Sampling AD biomarkers just as they exit the brain ups sensitivity, but the bump might not be worth the trouble. 19 Jun 2026 11:17:48 EDT https://www.alzforum.org/news/research-news/tapping-jugular-boosts-alzheimers-biomarker-performance#comments https://www.alzforum.org/news/community-news/psa-check-your-tau-antibody-and-other-reagent-datasheets Antibody to plant homeodomain finger protein 1, a.k.a. PHF1, does not bind tau paired helical fragments. 18 Jun 2026 16:41:18 EDT https://www.alzforum.org/news/community-news/psa-check-your-tau-antibody-and-other-reagent-datasheets#comments https://www.alzforum.org/news/research-news/brain-computer-interface-means-independence-man-als Due to advancements in BCI technology, a man paralyzed by ALS “talks” to friends and family and independently operates his computer, even holding down a full-time job. 18 Jun 2026 13:07:26 EDT https://www.alzforum.org/news/research-news/brain-computer-interface-means-independence-man-als#comments https://www.alzforum.org/news/conference-coverage/tdp-43-conference-slow-progress-imaging-markers PET tracers are not clinic-ready. An MRI algorithm could detect TDP-43 co-pathology in aging brains. Scientists propose a new term. 18 Jun 2026 10:32:21 EDT https://www.alzforum.org/news/conference-coverage/tdp-43-conference-slow-progress-imaging-markers#comments https://www.alzforum.org/news/research-news/does-mutant-tau-stall-neuronal-cargo-pathology-strikes Caught on camera: Tau-driven transport failure in the brains of live mice. 14 Jun 2026 08:50:41 EDT https://www.alzforum.org/news/research-news/does-mutant-tau-stall-neuronal-cargo-pathology-strikes#comments https://www.alzforum.org/news/research-news/pigs-space-transcriptomics-link-microglia-resilience-or-dementia Plaque-induced genes changed in two main waves of microglial responses to Aβ and tau pathology. Could these pivots underlie whether a person with amyloid pathology develops dementia? 12 Jun 2026 14:22:42 EDT https://www.alzforum.org/news/research-news/pigs-space-transcriptomics-link-microglia-resilience-or-dementia#comments https://www.alzforum.org/news/research-news/microglia-open-fuel-pipeline-active-neurons By coordinating metabolic coupling among endothelial cells, astrocytes, and neurons, microglia fuel protein synthesis in hungry neurons. 11 Jun 2026 15:01:01 EDT https://www.alzforum.org/news/research-news/microglia-open-fuel-pipeline-active-neurons#comments https://www.alzforum.org/news/research-news/new-twist-tying-rna-chaperones-try-circle A circular RNA bound TDP-43, and prevented its aggregation, with four times the efficiency of a linear version. 10 Jun 2026 15:56:07 EDT https://www.alzforum.org/news/research-news/new-twist-tying-rna-chaperones-try-circle#comments https://www.alzforum.org/news/research-news/new-bigger-gwas-meta-analysis-turns-more-hits The latest Alzheimer’s disease genome-wide association study finds 16 new risk loci and 25 new variants in known AD loci. 05 Jun 2026 16:14:46 EDT https://www.alzforum.org/news/research-news/new-bigger-gwas-meta-analysis-turns-more-hits#comments https://www.alzforum.org/news/research-news/meningeal-matrix-reloaded-proteomics-finds-changes-ad-brain In the leptomeninges in Alzheimer’s disease, an extracellular matrix makeover suggests altered cell-cell signaling and coagulation. 05 Jun 2026 13:45:20 EDT https://www.alzforum.org/news/research-news/meningeal-matrix-reloaded-proteomics-finds-changes-ad-brain#comments https://www.alzforum.org/news/research-news/even-midlife-alzheimers-biomarkers-blood-spell-trouble In a community cohort, biomarker-positive people had worse processing speed and executive function and declined faster. Together, plasma p-tau217 and eMTBR-tau243 can accurately predict a person’s brain pathology as per PET. 05 Jun 2026 07:51:55 EDT https://www.alzforum.org/news/research-news/even-midlife-alzheimers-biomarkers-blood-spell-trouble#comments https://www.alzforum.org/news/research-news/neuroproteasomes-chew-tau-it-tangles Blocking specialized proteasomes in the neuronal cell membrane triggers rapid tau aggregation. ApoE4 depletes these specialized proteasomes from the plasma membrane. 04 Jun 2026 11:15:22 EDT https://www.alzforum.org/news/research-news/neuroproteasomes-chew-tau-it-tangles#comments https://www.alzforum.org/news/research-news/synapses-suffer-when-splicing-goes-awry-tdp-43-proteinopathy Suppressing mis-splicing of four transcripts rescued synaptic transmission in induced human neurons. 03 Jun 2026 15:16:12 EDT https://www.alzforum.org/news/research-news/synapses-suffer-when-splicing-goes-awry-tdp-43-proteinopathy#comments https://www.alzforum.org/news/research-news/staging-alzheimers-now-blood-tests Together, plasma p-tau217 and eMTBR-tau243 can accurately predict a person’s brain pathology as per PET. 30 May 2026 06:17:12 EDT https://www.alzforum.org/news/research-news/staging-alzheimers-now-blood-tests#comments https://www.alzforum.org/news/research-news/fibrils-tubulin-polymerization-protein-distinguish-msa-parkinsons TPPP twists into amyloid fibrils. An assay that amplifies them distinguishes multiple system atrophy from other neurological disorders. 29 May 2026 14:43:04 EDT https://www.alzforum.org/news/research-news/fibrils-tubulin-polymerization-protein-distinguish-msa-parkinsons#comments https://www.alzforum.org/news/research-news/brain-waste-please-proceed-your-nearest-exit A new mouse model shows neuronal proteins drain from the parenchyma through a variety of routes. 29 May 2026 12:15:19 EDT https://www.alzforum.org/news/research-news/brain-waste-please-proceed-your-nearest-exit#comments