https://www.alzforum.org en https://www.alzforum.org/news/conference-coverage/bespoke-shuttles-scientists-tailor-transporters-therapeutic-targets Oligonucleotide-based therapies are increasingly being fitted with shuttle constructs. Is TfR always the best choice? 05 Aug 2026 13:26:05 EDT https://www.alzforum.org/news/conference-coverage/bespoke-shuttles-scientists-tailor-transporters-therapeutic-targets#comments https://www.alzforum.org/news/conference-coverage/brain-shuttles-coming-boom Extending well beyond anti-Aβ antibodies, development of brain-shuttled therapies for AD has become highly competitive. 05 Aug 2026 13:24:14 EDT https://www.alzforum.org/news/conference-coverage/brain-shuttles-coming-boom#comments https://www.alzforum.org/news/conference-coverage/blood-test-cerebrovascular-disease-horizon Disease in the blood vessels of the brain increases a person’s risk for dementia, but there is no easy way to measure it. At AAIC, scientists reported blood marker panels that might. 04 Aug 2026 16:22:58 EDT https://www.alzforum.org/news/conference-coverage/blood-test-cerebrovascular-disease-horizon#comments https://www.alzforum.org/news/conference-coverage/proteomic-meta-analysis-paints-landscape-neurological-markers The concentrations of 42 proteins in CSF show different patterns in 41 neurological disorders. 04 Aug 2026 14:54:48 EDT https://www.alzforum.org/news/conference-coverage/proteomic-meta-analysis-paints-landscape-neurological-markers#comments https://www.alzforum.org/news/conference-coverage/cognitively-sharp-centenarians-sidestep-tau-pathology Despite an amyloid burden on par with Alzheimer's disease, many centenarians keep tau tangles at bay. 04 Aug 2026 10:17:04 EDT https://www.alzforum.org/news/conference-coverage/cognitively-sharp-centenarians-sidestep-tau-pathology#comments https://www.alzforum.org/news/conference-coverage/immunotherapy-use-grows-us-clinics-innovate-handle-load Greater reliance on trained nurses and primary care, as well as the availability of subcutaneous lecanemab, may help accommodate growing caseloads. 31 Jul 2026 17:38:42 EDT https://www.alzforum.org/news/conference-coverage/immunotherapy-use-grows-us-clinics-innovate-handle-load#comments https://www.alzforum.org/news/conference-coverage/china-and-us-real-world-use-leqembi-seems-stabilize-cognition As cohorts expand, with a few people reaching three years on drug, accumulating data suggests their Alzheimer’s disease has slowed. 31 Jul 2026 16:12:26 EDT https://www.alzforum.org/news/conference-coverage/china-and-us-real-world-use-leqembi-seems-stabilize-cognition#comments https://www.alzforum.org/news/conference-coverage/de-risking-donanemab-dosing-tweak-cuts-aria-steroids-not-so-much As cohorts expand, with a few people reaching three years on drug, accumulating data suggests their Alzheimer’s disease has slowed. 31 Jul 2026 13:10:21 EDT https://www.alzforum.org/news/conference-coverage/de-risking-donanemab-dosing-tweak-cuts-aria-steroids-not-so-much#comments https://www.alzforum.org/news/conference-coverage/plasma-p-tau217-test-improves-diagnosis-clinician-confidence In primary and secondary care in Sweden, the blood test led to changes in diagnosis and disease management. 30 Jul 2026 18:03:50 EDT https://www.alzforum.org/news/conference-coverage/plasma-p-tau217-test-improves-diagnosis-clinician-confidence#comments https://www.alzforum.org/news/conference-coverage/scientists-chart-tau-modifications-alzheimers-advances At AAIC, scientists map the myriad of post-translational modifications tau accrues through pathology stages. One goal: new biomarkers. 28 Jul 2026 15:43:59 EDT https://www.alzforum.org/news/conference-coverage/scientists-chart-tau-modifications-alzheimers-advances#comments https://www.alzforum.org/news/conference-coverage/can-p-tau217-predict-alzheimers-symptoms-healthy-people Data shown at AAIC suggests that the plasma marker helps determine whose cognition will decline within two to 10 years. But no slam dunk. 28 Jul 2026 13:27:58 EDT https://www.alzforum.org/news/conference-coverage/can-p-tau217-predict-alzheimers-symptoms-healthy-people#comments https://www.alzforum.org/news/conference-coverage/preventron-and-beyond A secondary prevention trial evaluating trontinemab’s ability to keep symptoms at bay in people with brain amyloid deposition will start later this year. 24 Jul 2026 17:24:29 EDT https://www.alzforum.org/news/conference-coverage/preventron-and-beyond#comments https://www.alzforum.org/news/conference-coverage/open-label-extension-trontinemab-keeps-amyloid-bay In Phase 2 OLE, brain amyloid dropped further below threshold of positivity, plasma kept going down GFAP. Phase 3 trials are enrolling. 24 Jul 2026 17:01:08 EDT https://www.alzforum.org/news/conference-coverage/open-label-extension-trontinemab-keeps-amyloid-bay#comments https://www.alzforum.org/news/conference-coverage/tspo-ftd-marker-microglia-munching-myelin At AAIC, researchers report that TSPO-PET signals in frontotemporal dementia come from phagocytic microglia amassing in white matter. 24 Jul 2026 14:03:47 EDT https://www.alzforum.org/news/conference-coverage/tspo-ftd-marker-microglia-munching-myelin#comments https://www.alzforum.org/news/conference-coverage/c-brain-releases-its-first-four-ai-tools-alzheimers-scientists The open-source tools are still in development. C-BRAIN has opened them to the scientific community to try them and offer feedback. 24 Jul 2026 12:33:41 EDT https://www.alzforum.org/news/conference-coverage/c-brain-releases-its-first-four-ai-tools-alzheimers-scientists#comments https://www.alzforum.org/news/conference-coverage/longitudinal-pet-scans-reveal-amyloid-immunotherapy-use In an observational study, marked drops in brain amyloid flagged people who, unbeknownst to investigators, had started anti-amyloid therapy. 22 Jul 2026 18:53:50 EDT https://www.alzforum.org/news/conference-coverage/longitudinal-pet-scans-reveal-amyloid-immunotherapy-use#comments https://www.alzforum.org/news/conference-coverage/tau-aso-phase-2-data-draw-crowd-mixed-reactions At AAIC, Biogen presented diranersen data. Despite missing its endpoint, the drug showed enough target engagement and cognitive benefit to go to Phase 3. 22 Jul 2026 18:47:06 EDT https://www.alzforum.org/news/conference-coverage/tau-aso-phase-2-data-draw-crowd-mixed-reactions#comments https://www.alzforum.org/news/research-news/two-new-ways-attack-tdp-43 A molecule that binds TDP-43 extends survival in ALS mice. Interrupting steric zippers stops aggregation of a short TDP-43 isoform; alters RNA splicing. 18 Jul 2026 19:54:47 EDT https://www.alzforum.org/news/research-news/two-new-ways-attack-tdp-43#comments https://www.alzforum.org/news/research-news/does-tau-board-capsids-sail-across-synapses The synaptic plasticity protein Arc—an evolutionary cousin to viral capsids—escorts tau into extracellular vesicles. Lentiviruses carry seed-competent tau between cells. 17 Jul 2026 19:09:15 EDT https://www.alzforum.org/news/research-news/does-tau-board-capsids-sail-across-synapses#comments https://www.alzforum.org/news/research-news/minus-tdp-43-microglia-fumble-myelin-cleanup Depleting TDP-43 in microglia causes the TREM2 partner Tyrobp to pick up a cryptic exon, hobbling signals managing myelin. 16 Jul 2026 14:07:05 EDT https://www.alzforum.org/news/research-news/minus-tdp-43-microglia-fumble-myelin-cleanup#comments https://www.alzforum.org/news/research-news/massive-meta-analysis-pegs-centiloid-positivity-thresholds Data from 50,000 people identified18 centiloids as the best single cutoff, 11 and 26 as the best double cutoffs. 16 Jul 2026 11:05:13 EDT https://www.alzforum.org/news/research-news/massive-meta-analysis-pegs-centiloid-positivity-thresholds#comments https://www.alzforum.org/news/research-news/does-apoe4-act-through-oligodendrocytes Both X-linked and cell-type GWAS suggest that APOE4 perturbs myelination, particularly in women, offering a clue to their higher AD risk. 11 Jul 2026 07:15:21 EDT https://www.alzforum.org/news/research-news/does-apoe4-act-through-oligodendrocytes#comments https://www.alzforum.org/news/research-news/immune-shocker-mouse-brain-b-cells-drive-synaptic-pruning Frenzied neuronal activity recruits B cells. IgMs combine with complement to mark synapses for pruning. In an AD model, dampening neuronal firing stymies synaptic loss. 09 Jul 2026 18:12:03 EDT https://www.alzforum.org/news/research-news/immune-shocker-mouse-brain-b-cells-drive-synaptic-pruning#comments https://www.alzforum.org/news/research-news/succumbing-als-neurons-descend-disease-state As disease worsens, alpha motor neurons increasingly transition into a newly identified state, featuring a mix of protective and degenerative signals. 09 Jul 2026 15:48:31 EDT https://www.alzforum.org/news/research-news/succumbing-als-neurons-descend-disease-state#comments https://www.alzforum.org/news/research-news/proteome-wide-association-study-points-new-alzheimers-genes Plasma PWAS identifies 18 AD risk genes that regulate abundance of proteins in plasma. Three are new. 05 Jul 2026 10:49:45 EDT https://www.alzforum.org/news/research-news/proteome-wide-association-study-points-new-alzheimers-genes#comments https://www.alzforum.org/news/research-news/rare-variants-offer-clues-apoe-toxicity-lipidation-aggregation A new protective variant, W276C, lowers ApoE’s propensity to aggregate, while risk variant R189C boosts its lipidation, messing up microglial metabolism. 02 Jul 2026 18:06:19 EDT https://www.alzforum.org/news/research-news/rare-variants-offer-clues-apoe-toxicity-lipidation-aggregation#comments https://www.alzforum.org/news/research-news/membrane-fix-flat-ftd-proteins-patch-cell-surface Annexin-A11 forms a temporary plug, then the ESCRT-III complex pinches it off to finish the repair. 02 Jul 2026 11:49:58 EDT https://www.alzforum.org/news/research-news/membrane-fix-flat-ftd-proteins-patch-cell-surface#comments https://www.alzforum.org/news/research-news/low-csf-tmem106b-sign-disease-or-just-good-genes People with frontotemporal dementia or Alzheimer’s disease have less TMEM106B in their cerebrospinal fluid. But so do people who carry a protective variant. 01 Jul 2026 18:09:54 EDT https://www.alzforum.org/news/research-news/low-csf-tmem106b-sign-disease-or-just-good-genes#comments https://www.alzforum.org/news/research-news/amyloid-stokes-toxic-mrna-mitochondria-and-inflammation-flares Under healthy conditions, neurons degrade mitochondrial mRNA that leaks into the cytosol. Not when amyloid is around. 26 Jun 2026 16:28:07 EDT https://www.alzforum.org/news/research-news/amyloid-stokes-toxic-mrna-mitochondria-and-inflammation-flares#comments https://www.alzforum.org/news/research-news/plasma-proteome-offers-clues-risk-and-resilience-apoe4-carriers APOE2 and APOE4 carriers have distinct profiles that are not simple opposites. APOE4 carriers who keep their memories sharp express protective genes. 26 Jun 2026 12:37:14 EDT https://www.alzforum.org/news/research-news/plasma-proteome-offers-clues-risk-and-resilience-apoe4-carriers#comments