https://www.alzforum.org en https://www.alzforum.org/news/research-news/human-organoids-refill-hollowed-out-mouse-brain Three-dimensional iPSC cultures grafted into genetically hollowed-out mouse cortex form connections with host circuits. 18 Sep 2026 19:57:29 EDT https://www.alzforum.org/news/research-news/human-organoids-refill-hollowed-out-mouse-brain#comments https://www.alzforum.org/news/research-news/gwas-nets-genes-alter-apoe4-risk A stratified genome-wide meta-analysis picks out four loci that affect Alzheimer’s risk differently in APOE4 versus APOE3 carriers. 18 Sep 2026 18:05:18 EDT https://www.alzforum.org/news/research-news/gwas-nets-genes-alter-apoe4-risk#comments https://www.alzforum.org/news/research-news/flying-under-radar-microproteins-may-contribute-alzheimers A new atlas of small proteins in the frontal cortex shows that many change abundance in AD, including one that fatigues microglia. 18 Sep 2026 15:37:08 EDT https://www.alzforum.org/news/research-news/flying-under-radar-microproteins-may-contribute-alzheimers#comments https://www.alzforum.org/news/research-news/molecule-molecule-new-tech-maps-taus-many-forms Scientists measure tau proteoforms at single-molecule resolution, revealing how splicing and phosphorylation combine. It works in Alzheimer’s tissue. P-tau217 happens as a late event. 17 Sep 2026 07:54:38 EDT https://www.alzforum.org/news/research-news/molecule-molecule-new-tech-maps-taus-many-forms#comments https://www.alzforum.org/news/research-news/nagging-pain-av42-accumulation-could-be-blame-claim-scientists In response to a paw injury, neurons in mouse spinal cord cranked out Aβ42, which set off a cycle of chronic pain. 15 Sep 2026 21:02:58 EDT https://www.alzforum.org/news/research-news/nagging-pain-av42-accumulation-could-be-blame-claim-scientists#comments https://www.alzforum.org/news/research-news/polyubiquitin-may-dictate-structure-tau-fibrils When scientists tweaked the posttranslational modification, the fibrils' cores shape-shifted. 11 Sep 2026 16:58:23 EDT https://www.alzforum.org/news/research-news/polyubiquitin-may-dictate-structure-tau-fibrils#comments https://www.alzforum.org/news/research-news/can-alzheimers-mess-bone-marrow-monocytes In AD mouse models monocyte development stalls, and few get into the brain. Blocking interferon signaling restored monocytes and slowed hippocampal neurodegeneration. 11 Sep 2026 09:01:10 EDT https://www.alzforum.org/news/research-news/can-alzheimers-mess-bone-marrow-monocytes#comments https://www.alzforum.org/news/research-news/delivered-vesicle-antibody-tamps-down-tau-tdp-43 Pathologic deposits fade in cultured neurons and mouse brain treated with antibodies that are fused to autophagosome protein LC3. 10 Sep 2026 15:09:04 EDT https://www.alzforum.org/news/research-news/delivered-vesicle-antibody-tamps-down-tau-tdp-43#comments https://www.alzforum.org/news/research-news/can-peripheral-antigen-presenting-cells-hasten-tauopathies Immune dendritic cells prime CD8 T cells to exacerbate neurodegeneration in tauopathy mice. 04 Sep 2026 18:56:00 EDT https://www.alzforum.org/news/research-news/can-peripheral-antigen-presenting-cells-hasten-tauopathies#comments https://www.alzforum.org/news/research-news/apoe4-astrocytes-stoke-synuclein-pathology-brain-organoids In organoids made of six major brain-cell types, cholesterol-laden APOE4 astrocytes fuel accumulation of phosphorylated α-synuclein in neurons. 04 Sep 2026 15:22:42 EDT https://www.alzforum.org/news/research-news/apoe4-astrocytes-stoke-synuclein-pathology-brain-organoids#comments https://www.alzforum.org/news/research-news/does-rogue-receptor-drive-synapse-loss-early-alzheimers-disease In mice, amyloid triggered the expression of ERBB4 in excitatory neurons. Switching off the receptor curbed synapse loss, limited plaque buildup, and restored memory. 02 Sep 2026 16:20:49 EDT https://www.alzforum.org/news/research-news/does-rogue-receptor-drive-synapse-loss-early-alzheimers-disease#comments https://www.alzforum.org/news/research-news/too-much-myelin-bad-brain In postmortem corpus callosum from people with age-related cognitive decline, myelin was thicker and looser, axons smaller, and oligodendrocytes abundant. 02 Sep 2026 11:33:31 EDT https://www.alzforum.org/news/research-news/too-much-myelin-bad-brain#comments https://www.alzforum.org/news/research-news/fda-clears-c2ns-precivity-ad2-and-roches-elecsys-p-tau217-tests Roche’s is the first stand-alone p-tau217 test to win the seal of approval. 28 Aug 2026 20:03:17 EDT https://www.alzforum.org/news/research-news/fda-clears-c2ns-precivity-ad2-and-roches-elecsys-p-tau217-tests#comments https://www.alzforum.org/news/research-news/new-alzheimers-variant-may-help-scarf-down-amyloid Exome study uncovers protective chromosome 22 duplication that modifies AD risk. 28 Aug 2026 15:58:16 EDT https://www.alzforum.org/news/research-news/new-alzheimers-variant-may-help-scarf-down-amyloid#comments https://www.alzforum.org/news/research-news/apoe-shapes-proteome-astrocyte-lipid-droplets In iPSC-derived astrocytes, the protein composition and turnover rate of lipid droplets differ by APOE genotype. 28 Aug 2026 13:01:34 EDT https://www.alzforum.org/news/research-news/apoe-shapes-proteome-astrocyte-lipid-droplets#comments https://www.alzforum.org/news/research-news/brain-ages-infiltrating-monocytes-replace-native-microglia Using mutations and epigenetics to track cellular origins, two studies report human microglia shift from yolk-sac-derived to monocyte-derived starting about age 50. 27 Aug 2026 18:02:52 EDT https://www.alzforum.org/news/research-news/brain-ages-infiltrating-monocytes-replace-native-microglia#comments https://www.alzforum.org/news/research-news/meet-mitochondrial-plaque-new-alzheimers-pathology In amyloid mice and postmortem human AD brain, mitochondria-packed dystrophic neurites appear to cluster into large, “plaque-like” structures. 26 Aug 2026 12:21:39 EDT https://www.alzforum.org/news/research-news/meet-mitochondrial-plaque-new-alzheimers-pathology#comments https://www.alzforum.org/news/research-news/splicing-modulator-stops-4r-tau-source-lowers-pathology In transgenic mice and human neurons, the compound lowered aggregation-prone 4R tau, p-tau, insoluble tau. It needs further tweaking for stability and selectivity. 21 Aug 2026 15:45:36 EDT https://www.alzforum.org/news/research-news/splicing-modulator-stops-4r-tau-source-lowers-pathology#comments https://www.alzforum.org/news/research-news/therapeutic-twofer-supplies-progranulin-evades-sortilin In mice, viral delivery of this modified protein outperformed conventional progranulin on multiple fronts. 21 Aug 2026 14:17:50 EDT https://www.alzforum.org/news/research-news/therapeutic-twofer-supplies-progranulin-evades-sortilin#comments https://www.alzforum.org/news/research-news/how-specialized-macrophages-defend-brains-borders The transcription factor c-MAF programs specialized border-associated macrophages to maintain a healthy cerebrovasculature and protect against Alzheimer’s. Not so in ApoE4 carriers. 20 Aug 2026 10:25:47 EDT https://www.alzforum.org/news/research-news/how-specialized-macrophages-defend-brains-borders#comments https://www.alzforum.org/news/research-news/senescent-microglia-release-protein-disrupts-myelin-riles-neurons The newly identified senescence factor, sDLK1, binds Notch, hampers oligodendrocyte maturation, and perturbs neuronal calcium signaling. It rises with age. 19 Aug 2026 15:18:06 EDT https://www.alzforum.org/news/research-news/senescent-microglia-release-protein-disrupts-myelin-riles-neurons#comments https://www.alzforum.org/news/conference-coverage/early-menopause-warning-sign-alzheimers Molecular changes unfolding during menopause might render the brain more vulnerable to dementia in some women. Topping the list: inflammation and synaptic dysfunction. 18 Aug 2026 09:33:35 EDT https://www.alzforum.org/news/conference-coverage/early-menopause-warning-sign-alzheimers#comments https://www.alzforum.org/news/research-news/phospho-tau-infiltrates-mitochondria-reverses-electron-flow In tauopathy mice, reverse electron transport runs rampant. Blocking it curbs neurodegeneration. 14 Aug 2026 17:14:19 EDT https://www.alzforum.org/news/research-news/phospho-tau-infiltrates-mitochondria-reverses-electron-flow#comments https://www.alzforum.org/news/conference-coverage/might-ai-help-sharpen-dementia-diagnosis Researchers unveil an AI model designed to use medical records to predict the underlying neuropathology driving a person’s cognitive dysfunction. 13 Aug 2026 01:16:58 EDT https://www.alzforum.org/news/conference-coverage/might-ai-help-sharpen-dementia-diagnosis#comments https://www.alzforum.org/news/conference-coverage/do-younger-people-clear-plaque-slowly-because-they-have-more-tangles The age effect may actually be a tau effect as tangles hamper antibody efficacy; new data add evidence that lecanemab slows tau buildup. 12 Aug 2026 15:49:04 EDT https://www.alzforum.org/news/conference-coverage/do-younger-people-clear-plaque-slowly-because-they-have-more-tangles#comments https://www.alzforum.org/news/conference-coverage/better-never-late-tdp-43-pathology-alzheimers-disease TDP-43 co-pathology means other proteins are more likely to aggregate in Alzheimer's disease. 12 Aug 2026 12:56:05 EDT https://www.alzforum.org/news/conference-coverage/better-never-late-tdp-43-pathology-alzheimers-disease#comments https://www.alzforum.org/news/research-news/two-diseases-one-microglial-response-lame-lysosomes In neurodegenerative diseases driven by lysosomal dysfunction, microglia initiate a transcriptional program that first helps, then hinders. 11 Aug 2026 13:18:23 EDT https://www.alzforum.org/news/research-news/two-diseases-one-microglial-response-lame-lysosomes#comments https://www.alzforum.org/news/conference-coverage/healthy-arteries-slow-titration-mean-less-aria Scientists linked APOE2 and diastolic blood pressure to ARIA-E. More slowly upping antibody dose lessens the risk. Better patient screening lowers ARIA-H. 07 Aug 2026 15:05:40 EDT https://www.alzforum.org/news/conference-coverage/healthy-arteries-slow-titration-mean-less-aria#comments https://www.alzforum.org/news/conference-coverage/bespoke-shuttles-scientists-tailor-transporters-therapeutic-targets Oligonucleotide-based therapies are increasingly being fitted with shuttle constructs. Is TfR always the best choice? 05 Aug 2026 13:26:05 EDT https://www.alzforum.org/news/conference-coverage/bespoke-shuttles-scientists-tailor-transporters-therapeutic-targets#comments https://www.alzforum.org/news/conference-coverage/brain-shuttles-coming-boom Extending well beyond anti-Aβ antibodies, development of brain-shuttled therapies for AD has become highly competitive. 05 Aug 2026 13:24:14 EDT https://www.alzforum.org/news/conference-coverage/brain-shuttles-coming-boom#comments