https://www.alzforum.org en https://www.alzforum.org/news/research-news/meet-mitochondrial-plaque-new-alzheimers-pathology In amyloid mice and postmortem human AD brain, mitochondria-packed dystrophic neurites appear to cluster into large, “plaque-like” structures. 26 Aug 2026 12:21:39 EDT https://www.alzforum.org/news/research-news/meet-mitochondrial-plaque-new-alzheimers-pathology#comments https://www.alzforum.org/news/research-news/splicing-modulator-stops-4r-tau-source-lowers-pathology In transgenic mice and human neurons, the compound lowered aggregation-prone 4R tau, p-tau, insoluble tau. It needs further tweaking for stability and selectivity. 21 Aug 2026 15:45:36 EDT https://www.alzforum.org/news/research-news/splicing-modulator-stops-4r-tau-source-lowers-pathology#comments https://www.alzforum.org/news/research-news/therapeutic-twofer-supplies-progranulin-evades-sortilin In mice, viral delivery of this modified protein outperformed conventional progranulin on multiple fronts. 21 Aug 2026 14:17:50 EDT https://www.alzforum.org/news/research-news/therapeutic-twofer-supplies-progranulin-evades-sortilin#comments https://www.alzforum.org/news/research-news/how-specialized-macrophages-defend-brains-borders The transcription factor c-MAF programs specialized border-associated macrophages to maintain a healthy cerebrovasculature and protect against Alzheimer’s. Not so in ApoE4 carriers. 20 Aug 2026 10:25:47 EDT https://www.alzforum.org/news/research-news/how-specialized-macrophages-defend-brains-borders#comments https://www.alzforum.org/news/research-news/senescent-microglia-release-protein-disrupts-myelin-riles-neurons The newly identified senescence factor, sDLK1, binds Notch, hampers oligodendrocyte maturation, and perturbs neuronal calcium signaling. It rises with age. 19 Aug 2026 15:18:06 EDT https://www.alzforum.org/news/research-news/senescent-microglia-release-protein-disrupts-myelin-riles-neurons#comments https://www.alzforum.org/news/conference-coverage/early-menopause-warning-sign-alzheimers Molecular changes unfolding during menopause might render the brain more vulnerable to dementia in some women. Topping the list: inflammation and synaptic dysfunction. 18 Aug 2026 09:33:35 EDT https://www.alzforum.org/news/conference-coverage/early-menopause-warning-sign-alzheimers#comments https://www.alzforum.org/news/research-news/phospho-tau-infiltrates-mitochondria-reverses-electron-flow In tauopathy mice, reverse electron transport runs rampant. Blocking it curbs neurodegeneration. 14 Aug 2026 17:14:19 EDT https://www.alzforum.org/news/research-news/phospho-tau-infiltrates-mitochondria-reverses-electron-flow#comments https://www.alzforum.org/news/conference-coverage/might-ai-help-sharpen-dementia-diagnosis Researchers unveil an AI model designed to use medical records to predict the underlying neuropathology driving a person’s cognitive dysfunction. 13 Aug 2026 01:16:58 EDT https://www.alzforum.org/news/conference-coverage/might-ai-help-sharpen-dementia-diagnosis#comments https://www.alzforum.org/news/conference-coverage/do-younger-people-clear-plaque-slowly-because-they-have-more-tangles The age effect may actually be a tau effect as tangles hamper antibody efficacy; new data add evidence that lecanemab slows tau buildup. 12 Aug 2026 15:49:04 EDT https://www.alzforum.org/news/conference-coverage/do-younger-people-clear-plaque-slowly-because-they-have-more-tangles#comments https://www.alzforum.org/news/conference-coverage/better-never-late-tdp-43-pathology-alzheimers-disease TDP-43 co-pathology means other proteins are more likely to aggregate in Alzheimer's disease. 12 Aug 2026 12:56:05 EDT https://www.alzforum.org/news/conference-coverage/better-never-late-tdp-43-pathology-alzheimers-disease#comments https://www.alzforum.org/news/research-news/two-diseases-one-microglial-response-lame-lysosomes In neurodegenerative diseases driven by lysosomal dysfunction, microglia initiate a transcriptional program that first helps, then hinders. 11 Aug 2026 13:18:23 EDT https://www.alzforum.org/news/research-news/two-diseases-one-microglial-response-lame-lysosomes#comments https://www.alzforum.org/news/conference-coverage/healthy-arteries-slow-titration-mean-less-aria Scientists linked APOE2 and diastolic blood pressure to ARIA-E. More slowly upping antibody dose lessens the risk. Better patient screening lowers ARIA-H. 07 Aug 2026 15:05:40 EDT https://www.alzforum.org/news/conference-coverage/healthy-arteries-slow-titration-mean-less-aria#comments https://www.alzforum.org/news/conference-coverage/bespoke-shuttles-scientists-tailor-transporters-therapeutic-targets Oligonucleotide-based therapies are increasingly being fitted with shuttle constructs. Is TfR always the best choice? 05 Aug 2026 13:26:05 EDT https://www.alzforum.org/news/conference-coverage/bespoke-shuttles-scientists-tailor-transporters-therapeutic-targets#comments https://www.alzforum.org/news/conference-coverage/brain-shuttles-coming-boom Extending well beyond anti-Aβ antibodies, development of brain-shuttled therapies for AD has become highly competitive. 05 Aug 2026 13:24:14 EDT https://www.alzforum.org/news/conference-coverage/brain-shuttles-coming-boom#comments https://www.alzforum.org/news/conference-coverage/blood-test-cerebrovascular-disease-horizon Disease in the brain’s vasculature raises a person’s risk of dementia, but there is no easy way to measure it. At AAIC, scientists reported blood marker panels that might. 04 Aug 2026 16:22:58 EDT https://www.alzforum.org/news/conference-coverage/blood-test-cerebrovascular-disease-horizon#comments https://www.alzforum.org/news/conference-coverage/proteomic-meta-analysis-paints-landscape-neurological-markers The concentrations of 42 proteins in CSF show different patterns in 41 neurological disorders. 04 Aug 2026 14:54:48 EDT https://www.alzforum.org/news/conference-coverage/proteomic-meta-analysis-paints-landscape-neurological-markers#comments https://www.alzforum.org/news/conference-coverage/cognitively-sharp-centenarians-sidestep-tau-pathology Despite an amyloid burden on par with Alzheimer's disease, many centenarians keep tau tangles at bay. 04 Aug 2026 10:17:04 EDT https://www.alzforum.org/news/conference-coverage/cognitively-sharp-centenarians-sidestep-tau-pathology#comments https://www.alzforum.org/news/conference-coverage/immunotherapy-use-grows-us-clinics-innovate-handle-load Greater reliance on trained nurses and primary care, as well as the availability of subcutaneous lecanemab, may help accommodate growing caseloads. 31 Jul 2026 17:38:42 EDT https://www.alzforum.org/news/conference-coverage/immunotherapy-use-grows-us-clinics-innovate-handle-load#comments https://www.alzforum.org/news/conference-coverage/china-and-us-real-world-use-leqembi-seems-stabilize-cognition As cohorts expand, with a few people reaching three years on drug, accumulating data suggests their Alzheimer’s disease has slowed. 31 Jul 2026 16:12:26 EDT https://www.alzforum.org/news/conference-coverage/china-and-us-real-world-use-leqembi-seems-stabilize-cognition#comments https://www.alzforum.org/news/conference-coverage/de-risking-donanemab-dosing-tweak-cuts-aria-steroids-not-so-much As cohorts expand, with a few people reaching three years on drug, accumulating data suggests their Alzheimer’s disease has slowed. 31 Jul 2026 13:10:21 EDT https://www.alzforum.org/news/conference-coverage/de-risking-donanemab-dosing-tweak-cuts-aria-steroids-not-so-much#comments https://www.alzforum.org/news/conference-coverage/plasma-p-tau217-test-improves-diagnosis-clinician-confidence In primary and secondary care in Sweden, the blood test led to changes in diagnosis and disease management. 30 Jul 2026 18:03:50 EDT https://www.alzforum.org/news/conference-coverage/plasma-p-tau217-test-improves-diagnosis-clinician-confidence#comments https://www.alzforum.org/news/conference-coverage/scientists-chart-tau-modifications-alzheimers-advances At AAIC, scientists map the myriad of post-translational modifications tau accrues through pathology stages. One goal: new biomarkers. 28 Jul 2026 15:43:59 EDT https://www.alzforum.org/news/conference-coverage/scientists-chart-tau-modifications-alzheimers-advances#comments https://www.alzforum.org/news/conference-coverage/can-p-tau217-predict-alzheimers-symptoms-healthy-people Data shown at AAIC suggests that the plasma marker helps determine whose cognition will decline within two to 10 years. But no slam dunk. 28 Jul 2026 13:27:58 EDT https://www.alzforum.org/news/conference-coverage/can-p-tau217-predict-alzheimers-symptoms-healthy-people#comments https://www.alzforum.org/news/conference-coverage/preventron-and-beyond A secondary prevention trial evaluating trontinemab’s ability to keep symptoms at bay in people with brain amyloid deposition will start later this year. 24 Jul 2026 17:24:29 EDT https://www.alzforum.org/news/conference-coverage/preventron-and-beyond#comments https://www.alzforum.org/news/conference-coverage/open-label-extension-trontinemab-keeps-amyloid-bay In Phase 2 OLE, brain amyloid dropped further below threshold of positivity, plasma kept going down GFAP. Phase 3 trials are enrolling. 24 Jul 2026 17:01:08 EDT https://www.alzforum.org/news/conference-coverage/open-label-extension-trontinemab-keeps-amyloid-bay#comments https://www.alzforum.org/news/conference-coverage/tspo-ftd-marker-microglia-munching-myelin At AAIC, researchers report that TSPO-PET signals in frontotemporal dementia come from phagocytic microglia amassing in white matter. 24 Jul 2026 14:03:47 EDT https://www.alzforum.org/news/conference-coverage/tspo-ftd-marker-microglia-munching-myelin#comments https://www.alzforum.org/news/conference-coverage/c-brain-releases-its-first-four-ai-tools-alzheimers-scientists The open-source tools are still in development. C-BRAIN has opened them to the scientific community to try them and offer feedback. 24 Jul 2026 12:33:41 EDT https://www.alzforum.org/news/conference-coverage/c-brain-releases-its-first-four-ai-tools-alzheimers-scientists#comments https://www.alzforum.org/news/conference-coverage/longitudinal-pet-scans-reveal-amyloid-immunotherapy-use In an observational study, marked drops in brain amyloid flagged people who, unbeknownst to investigators, had started anti-amyloid therapy. 22 Jul 2026 18:53:50 EDT https://www.alzforum.org/news/conference-coverage/longitudinal-pet-scans-reveal-amyloid-immunotherapy-use#comments https://www.alzforum.org/news/conference-coverage/tau-aso-phase-2-data-draw-crowd-mixed-reactions At AAIC, Biogen presented diranersen data. Despite missing its endpoint, the drug showed enough target engagement and cognitive benefit to go to Phase 3. 22 Jul 2026 18:47:06 EDT https://www.alzforum.org/news/conference-coverage/tau-aso-phase-2-data-draw-crowd-mixed-reactions#comments https://www.alzforum.org/news/research-news/two-new-ways-attack-tdp-43 A molecule that binds TDP-43 extends survival in ALS mice. Interrupting steric zippers stops aggregation of a short TDP-43 isoform; alters RNA splicing. 18 Jul 2026 19:54:47 EDT https://www.alzforum.org/news/research-news/two-new-ways-attack-tdp-43#comments