https://www.alzforum.org en https://www.alzforum.org/news/community-news/nvidia-board-c-brains-ai-models-get-boost C-BRAIN has teamed up with NVIDIA to scale up open-source AI models and speed discoveries in AD. Funded by ARPA-H, C-BRAIN will train an AI model on spatial proteomics from human brains. 30 Oct 2026 17:01:41 EDT https://www.alzforum.org/news/community-news/nvidia-board-c-brains-ai-models-get-boost#comments https://www.alzforum.org/news/community-news/streamlining-national-plan-hhs-prioritizes-prevention-innovation Pared down from six to four goals, the updated plan moves AD risk reduction and speeding the impact of scientific discoveries to the top of the list. 30 Oct 2026 16:36:32 EDT https://www.alzforum.org/news/community-news/streamlining-national-plan-hhs-prioritizes-prevention-innovation#comments https://www.alzforum.org/news/research-news/curiosity-keeps-mouse-memory-keen-mechanism-cognitive-reserve Exploration activated compensatory neuronal circuits in mice that counteracted the harmful effects of p-tau on attention and memory. 30 Oct 2026 14:10:09 EDT https://www.alzforum.org/news/research-news/curiosity-keeps-mouse-memory-keen-mechanism-cognitive-reserve#comments https://www.alzforum.org/news/research-news/hello-lipizone-unit-3d-lipid-map-mouse-brain Scanning the brains of adult mice reveals a mosaic of more than 500 distinct zones, each with its own lipid signature. 29 Oct 2026 18:35:02 EDT https://www.alzforum.org/news/research-news/hello-lipizone-unit-3d-lipid-map-mouse-brain#comments https://www.alzforum.org/news/research-news/cholesterol-overload-driver-neurodegeneration-parkinsons In mice, dialing down the cholesterol transporter ABCA1 curbed dopaminergic neuron loss and improved motor function. 28 Oct 2026 19:05:36 EDT https://www.alzforum.org/news/research-news/cholesterol-overload-driver-neurodegeneration-parkinsons#comments https://www.alzforum.org/news/research-news/chilly-conditions-rev-metabolic-response-prevent-protein-aggregates In worms, cold temps amped up production of the metabolite dihydrobiopterin. Neurons generated more tyrosine, and it juiced proteostasis. 27 Oct 2026 10:00:34 EDT https://www.alzforum.org/news/research-news/chilly-conditions-rev-metabolic-response-prevent-protein-aggregates#comments https://www.alzforum.org/news/research-news/tuberin-loss-angers-astrocytes-rapamycin-appeases-them Reactive astrocytes mark the neurodevelopmental disorder tuberous sclerosis. They crank out ApoE and clusterin. A potential link to Alzheimer’s? 23 Oct 2026 18:26:26 EDT https://www.alzforum.org/news/research-news/tuberin-loss-angers-astrocytes-rapamycin-appeases-them#comments https://www.alzforum.org/news/research-news/c4-who-knew-without-it-mice-make-less-amyloid Knocking out the complement factor eased plaque burden in 5xFAD mice. 23 Oct 2026 09:41:13 EDT https://www.alzforum.org/news/research-news/c4-who-knew-without-it-mice-make-less-amyloid#comments https://www.alzforum.org/news/research-news/repeat-offender-expanded-ccg-fam193b-gene-ups-ad-risk Long-read sequences expose a promoter repeat that SNP arrays had missed. It boosts gene expression. 22 Oct 2026 15:46:48 EDT https://www.alzforum.org/news/research-news/repeat-offender-expanded-ccg-fam193b-gene-ups-ad-risk#comments https://www.alzforum.org/news/research-news/mice-tuberculosis-jab-tempers-tau-pathology BCG vaccination dampens microglial activation, curbing phospho-tau accumulation and neurodegeneration in tauopathy mice. 22 Oct 2026 12:27:26 EDT https://www.alzforum.org/news/research-news/mice-tuberculosis-jab-tempers-tau-pathology#comments https://www.alzforum.org/news/research-news/apoe4-alters-epigenetics-other-genes Analysis of brain tissue turns up 107 methylation changes linked to Alzheimer’s disease. A set of 20 mediated 9 percent of APOE4’s effect on AD risk. 21 Oct 2026 17:47:17 EDT https://www.alzforum.org/news/research-news/apoe4-alters-epigenetics-other-genes#comments https://www.alzforum.org/news/research-news/phospholipase-stave-age-related-synapse-loss Mice with PLA2G2F had more dendritic spines in their hippocampi. Their memories were better, too. 21 Oct 2026 15:17:20 EDT https://www.alzforum.org/news/research-news/phospholipase-stave-age-related-synapse-loss#comments https://www.alzforum.org/news/research-news/network-tiny-conduits-flushes-fluid-brain Laid out as perivascular webs and superhighways, a fibroblast system rapidly ousts Aβ and tau. 16 Oct 2026 20:34:19 EDT https://www.alzforum.org/news/research-news/network-tiny-conduits-flushes-fluid-brain#comments https://www.alzforum.org/news/research-news/brain-shuttle-sirna-squelches-tau-cerebrospinal-fluid Arrowhead Pharmaceuticals’ ARO-MAPT suppressed tau by three-quarters for as long as three months in Phase 1. Phase 2 will enroll AD patients. 16 Oct 2026 16:48:38 EDT https://www.alzforum.org/news/research-news/brain-shuttle-sirna-squelches-tau-cerebrospinal-fluid#comments https://www.alzforum.org/news/research-news/randomized-trial-blood-tests-improved-care A study at a Spanish memory clinic showed that plasma p-tau217 and NfL firmed up diagnoses, reduced follow-up testing, and sped treatment. 16 Oct 2026 11:15:35 EDT https://www.alzforum.org/news/research-news/randomized-trial-blood-tests-improved-care#comments https://www.alzforum.org/news/research-news/does-gpnmb-subdue-synuclein-pathology-or-stoke-it Per one study, the glycoprotein helps microglia clear aggregates from neurons. Per another, secreted GPNMB worsens pathology by boosting fibril uptake. 15 Oct 2026 18:48:21 EDT https://www.alzforum.org/news/research-news/does-gpnmb-subdue-synuclein-pathology-or-stoke-it#comments https://www.alzforum.org/news/research-news/tauklarify-approval-widens-suite-ad-diagnostics Aka MK-6240, this tau PET tracer joins flortaucipir in the clinic, giving physicians a second option. FDA approval may make Tauklarify more available for research, too. 14 Oct 2026 12:01:38 EDT https://www.alzforum.org/news/research-news/tauklarify-approval-widens-suite-ad-diagnostics#comments https://www.alzforum.org/news/research-news/aphid-infests-lysosomes-living-brain-illuminating-their-ph Acid pH Indicator Dye, a custom fluorescent probe, revealed that most meningeal macrophages have weakly acidified lysosomes. Upon injury, the organelles lower their pH. 09 Oct 2026 15:11:15 EDT https://www.alzforum.org/news/research-news/aphid-infests-lysosomes-living-brain-illuminating-their-ph#comments https://www.alzforum.org/news/research-news/alternative-polyadenylation-could-explain-some-gwas-hits Scientists linked 168 GWAS loci for 17 brain disorders to variants that altered polyA tails. One such variant sent α-synuclein into neurites and hiked Parkinson’s risk. 09 Oct 2026 10:48:21 EDT https://www.alzforum.org/news/research-news/alternative-polyadenylation-could-explain-some-gwas-hits#comments https://www.alzforum.org/news/research-news/genotyping-surprise-tau-h1-haplotype-can-carry-h2-identifier In African-ancestry iPSC lines, scientists identified a sub-haplotype that contains a single-nucleotide polymorphism commonly used to identify H2. 08 Oct 2026 16:03:54 EDT https://www.alzforum.org/news/research-news/genotyping-surprise-tau-h1-haplotype-can-carry-h2-identifier#comments https://www.alzforum.org/news/research-news/can-ai-catch-aria-experts-weigh-pros-and-cons Neuroradiologists and Alzheimer’s clinicians agree that AI may improve detection. Some want more research on the value for patients. 07 Oct 2026 13:42:30 EDT https://www.alzforum.org/news/research-news/can-ai-catch-aria-experts-weigh-pros-and-cons#comments https://www.alzforum.org/news/research-news/old-drug-new-tricks-guanabenz-shows-signal-white-matter-disease In a Phase 1/2 trial, a blood pressure medication appeared to preserve children’s ability to walk, and lowered blood NfL. Does it target the integrated stress response? 07 Oct 2026 10:18:08 EDT https://www.alzforum.org/news/research-news/old-drug-new-tricks-guanabenz-shows-signal-white-matter-disease#comments https://www.alzforum.org/news/research-news/man-mouse-tau-strains-stay-true-structure Tau aggregates isolated from human AD or CBD brains seeded mouse tau to morph into fibrils matching their shape. Proof of prion-like templated misfolding? 01 Oct 2026 19:47:48 EDT https://www.alzforum.org/news/research-news/man-mouse-tau-strains-stay-true-structure#comments https://www.alzforum.org/news/research-news/new-twist-cryptic-rnas-they-come-circles Two groups found that TDP-43 loss creates stable, cryptic, circular RNAs. They could be biomarkers. A third reported that blocking cryptic UNC13A spares memory. 01 Oct 2026 16:27:19 EDT https://www.alzforum.org/news/research-news/new-twist-cryptic-rnas-they-come-circles#comments https://www.alzforum.org/news/research-news/apoe4-carriers-fibronectin-disturbs-blood-brain-barrier Too much fibronectin suppresses growth factor signaling between astrocytes and endothelial cells at this border zone. 25 Sep 2026 19:13:05 EDT https://www.alzforum.org/news/research-news/apoe4-carriers-fibronectin-disturbs-blood-brain-barrier#comments https://www.alzforum.org/news/research-news/apoe4-transforms-pericytes-trapping-amyloid-blood-vessels In postmortem brain and organoids, the Alzheimer’s risk allele turns pericytes into fibronectin-secreting myofibroblasts. 25 Sep 2026 18:50:55 EDT https://www.alzforum.org/news/research-news/apoe4-transforms-pericytes-trapping-amyloid-blood-vessels#comments https://www.alzforum.org/news/research-news/brain-biopsies-deliver-biochemistry-bonanza In a tiny piece of cortex from people undergoing shunt surgery, scientists measure Aβ and tau peptides, gauge a plaque’s age, and track newly minted tau. 25 Sep 2026 17:33:05 EDT https://www.alzforum.org/news/research-news/brain-biopsies-deliver-biochemistry-bonanza#comments https://www.alzforum.org/news/research-news/lecanemab-tells-brain-immune-cells-call-support-periphery In mice on amyloid immunotherapy, border-associated macrophages in the brain recruit monocytes and T cells from the blood. Does this spur ARIA? 24 Sep 2026 16:26:57 EDT https://www.alzforum.org/news/research-news/lecanemab-tells-brain-immune-cells-call-support-periphery#comments https://www.alzforum.org/news/research-news/bespoke-aso-slows-disease-one-man-rare-form-als Over one year of treatment with a CHCH10-targeted ASO, neurofilament light dipped into the normal range, and clinical symptoms stabilized or improved ever so slightly. 24 Sep 2026 15:15:19 EDT https://www.alzforum.org/news/research-news/bespoke-aso-slows-disease-one-man-rare-form-als#comments https://www.alzforum.org/news/research-news/hormone-replacement-therapy-when-it-good-brain New studies suggest that HRT might hedge dementia risk. They add to a sea of conflicting literature. 23 Sep 2026 15:15:39 EDT https://www.alzforum.org/news/research-news/hormone-replacement-therapy-when-it-good-brain#comments