https://www.alzforum.org en https://www.alzforum.org/news/research-news/plasma-proteome-offers-clues-risk-and-resilience-apoe4-carriers APOE2 and APOE4 carriers have distinct profiles that are not simple opposites. APOE4 carriers who keep their memories sharp express protective genes. 26 Jun 2026 12:37:14 EDT https://www.alzforum.org/news/research-news/plasma-proteome-offers-clues-risk-and-resilience-apoe4-carriers#comments https://www.alzforum.org/news/research-news/does-apoe4-prematurely-age-astrocytes Protein markers in blood suggest ApoE4 accelerates astrocyte aging. People with astrocytes older than their calendar age are more likely to get Alzheimer's. 25 Jun 2026 17:48:19 EDT https://www.alzforum.org/news/research-news/does-apoe4-prematurely-age-astrocytes#comments https://www.alzforum.org/news/conference-coverage/mjff-gathers-scientists-advance-synuclein-tracer-development Seven Michael J. Fox Foundation–funded groups are developing PET tracers for synucleinopathies. PPMI is gearing up to test the most promising. 24 Jun 2026 16:06:38 EDT https://www.alzforum.org/news/conference-coverage/mjff-gathers-scientists-advance-synuclein-tracer-development#comments https://www.alzforum.org/news/research-news/sickly-sweet-sugary-proteins-abound-ad-brain-may-worsen-dementia In mouse models, curbing glycosylation improved memory, boosting it worsened memory. Alzheimer’s patients who take glucosamine declined faster. 19 Jun 2026 12:43:13 EDT https://www.alzforum.org/news/research-news/sickly-sweet-sugary-proteins-abound-ad-brain-may-worsen-dementia#comments https://www.alzforum.org/news/research-news/tapping-jugular-boosts-alzheimers-biomarker-performance Sampling AD biomarkers just as they exit the brain ups sensitivity, but the bump might not be worth the trouble. 19 Jun 2026 11:17:48 EDT https://www.alzforum.org/news/research-news/tapping-jugular-boosts-alzheimers-biomarker-performance#comments https://www.alzforum.org/news/community-news/psa-check-your-tau-antibody-and-other-reagent-datasheets Antibody to plant homeodomain finger protein 1, a.k.a. PHF1, does not bind tau paired helical fragments. 18 Jun 2026 16:41:18 EDT https://www.alzforum.org/news/community-news/psa-check-your-tau-antibody-and-other-reagent-datasheets#comments https://www.alzforum.org/news/research-news/brain-computer-interface-means-independence-man-als Due to advancements in BCI technology, a man paralyzed by ALS “talks” to friends and family and independently operates his computer, even holding down a full-time job. 18 Jun 2026 13:07:26 EDT https://www.alzforum.org/news/research-news/brain-computer-interface-means-independence-man-als#comments https://www.alzforum.org/news/conference-coverage/tdp-43-conference-slow-progress-imaging-markers PET tracers are not clinic-ready. An MRI algorithm could detect TDP-43 co-pathology in aging brains. Scientists propose a new term. 18 Jun 2026 10:32:21 EDT https://www.alzforum.org/news/conference-coverage/tdp-43-conference-slow-progress-imaging-markers#comments https://www.alzforum.org/news/research-news/does-mutant-tau-stall-neuronal-cargo-pathology-strikes Caught on camera: Tau-driven transport failure in the brains of live mice. 14 Jun 2026 08:50:41 EDT https://www.alzforum.org/news/research-news/does-mutant-tau-stall-neuronal-cargo-pathology-strikes#comments https://www.alzforum.org/news/research-news/pigs-space-transcriptomics-link-microglia-resilience-or-dementia Plaque-induced genes changed in two main waves of microglial responses to Aβ and tau pathology. Could these pivots underlie whether a person with amyloid pathology develops dementia? 12 Jun 2026 14:22:42 EDT https://www.alzforum.org/news/research-news/pigs-space-transcriptomics-link-microglia-resilience-or-dementia#comments https://www.alzforum.org/news/research-news/microglia-open-fuel-pipeline-active-neurons By coordinating metabolic coupling among endothelial cells, astrocytes, and neurons, microglia fuel protein synthesis in hungry neurons. 11 Jun 2026 15:01:01 EDT https://www.alzforum.org/news/research-news/microglia-open-fuel-pipeline-active-neurons#comments https://www.alzforum.org/news/research-news/new-twist-tying-rna-chaperones-try-circle A circular RNA bound TDP-43, and prevented its aggregation, with four times the efficiency of a linear version. 10 Jun 2026 15:56:07 EDT https://www.alzforum.org/news/research-news/new-twist-tying-rna-chaperones-try-circle#comments https://www.alzforum.org/news/research-news/new-bigger-gwas-meta-analysis-turns-more-hits The latest Alzheimer’s disease genome-wide association study finds 16 new risk loci and 25 new variants in known AD loci. 05 Jun 2026 16:14:46 EDT https://www.alzforum.org/news/research-news/new-bigger-gwas-meta-analysis-turns-more-hits#comments https://www.alzforum.org/news/research-news/meningeal-matrix-reloaded-proteomics-finds-changes-ad-brain In the leptomeninges in Alzheimer’s disease, an extracellular matrix makeover suggests altered cell-cell signaling and coagulation. 05 Jun 2026 13:45:20 EDT https://www.alzforum.org/news/research-news/meningeal-matrix-reloaded-proteomics-finds-changes-ad-brain#comments https://www.alzforum.org/news/research-news/even-midlife-alzheimers-biomarkers-blood-spell-trouble In a community cohort, biomarker-positive people had worse processing speed and executive function and declined faster. Together, plasma p-tau217 and eMTBR-tau243 can accurately predict a person’s brain pathology as per PET. 05 Jun 2026 07:51:55 EDT https://www.alzforum.org/news/research-news/even-midlife-alzheimers-biomarkers-blood-spell-trouble#comments https://www.alzforum.org/news/research-news/neuroproteasomes-chew-tau-it-tangles Blocking specialized proteasomes in the neuronal cell membrane triggers rapid tau aggregation. ApoE4 depletes these specialized proteasomes from the plasma membrane. 04 Jun 2026 11:15:22 EDT https://www.alzforum.org/news/research-news/neuroproteasomes-chew-tau-it-tangles#comments https://www.alzforum.org/news/research-news/synapses-suffer-when-splicing-goes-awry-tdp-43-proteinopathy Suppressing mis-splicing of four transcripts rescued synaptic transmission in induced human neurons. 03 Jun 2026 15:16:12 EDT https://www.alzforum.org/news/research-news/synapses-suffer-when-splicing-goes-awry-tdp-43-proteinopathy#comments https://www.alzforum.org/news/research-news/staging-alzheimers-now-blood-tests Together, plasma p-tau217 and eMTBR-tau243 can accurately predict a person’s brain pathology as per PET. 30 May 2026 06:17:12 EDT https://www.alzforum.org/news/research-news/staging-alzheimers-now-blood-tests#comments https://www.alzforum.org/news/research-news/fibrils-tubulin-polymerization-protein-distinguish-msa-parkinsons TPPP twists into amyloid fibrils. An assay that amplifies them distinguishes multiple system atrophy from other neurological disorders. 29 May 2026 14:43:04 EDT https://www.alzforum.org/news/research-news/fibrils-tubulin-polymerization-protein-distinguish-msa-parkinsons#comments https://www.alzforum.org/news/research-news/brain-waste-please-proceed-your-nearest-exit A new mouse model shows neuronal proteins drain from the parenchyma through a variety of routes. 29 May 2026 12:15:19 EDT https://www.alzforum.org/news/research-news/brain-waste-please-proceed-your-nearest-exit#comments https://www.alzforum.org/news/conference-coverage/tau-fibrils-ensnare-rna-binding-protein-pinin-derailing-splicing Tau fibrils from different tauopathies sequester Pinin. Is this a general mechanism underlying tau toxicity? 29 May 2026 12:05:38 EDT https://www.alzforum.org/news/conference-coverage/tau-fibrils-ensnare-rna-binding-protein-pinin-derailing-splicing#comments https://www.alzforum.org/news/conference-coverage/one-tau-structure-one-disease-if-only-it-were-simple A distinct tau filament structure was identified in an S305I-tau mutation carrier, who had pathology akin to argyrophilic grain disease. It differed from structures found in sporadic disease. 23 May 2026 08:41:39 EDT https://www.alzforum.org/news/conference-coverage/one-tau-structure-one-disease-if-only-it-were-simple#comments https://www.alzforum.org/news/research-news/pi-2620-tracks-tau-changes-psp-ready-trials The PET tracer tracks tau buildup in progressive supranuclear palsy. Some think it could help drug development; others remain unconvinced. 23 May 2026 08:40:37 EDT https://www.alzforum.org/news/research-news/pi-2620-tracks-tau-changes-psp-ready-trials#comments https://www.alzforum.org/news/conference-coverage/two-new-tau-therapies-move-phase-3-psp-trials At the Tau Global conference, speakers showcased progress in an antisense oligonucleotide and a small-molecule p75 modulator. Other strategies also look promising. 23 May 2026 08:37:48 EDT https://www.alzforum.org/news/conference-coverage/two-new-tau-therapies-move-phase-3-psp-trials#comments https://www.alzforum.org/news/research-news/denali-biogen-halt-lrrk2-luma-parkinsons-trial The LRRK2 inhibitor DNL151/BIIB122 did not slow disease progression. Trial in familial PD to continue. 22 May 2026 15:16:17 EDT https://www.alzforum.org/news/research-news/denali-biogen-halt-lrrk2-luma-parkinsons-trial#comments https://www.alzforum.org/news/research-news/blocking-molecular-switch-keeps-microglia-working-after-stroke A transcription factor turned off microglial repair after a stroke. An antisense oligonucleotide turned it back on. Could this work for Alzheimer’s? 22 May 2026 14:09:28 EDT https://www.alzforum.org/news/research-news/blocking-molecular-switch-keeps-microglia-working-after-stroke#comments https://www.alzforum.org/news/research-news/plaque-removal-surrogate-statisticians-say-not-so-fast A new statistical analysis finds methodological flaws in a recent publication that linked plaque removal to cognitive benefit in the donanemab Phase 3 trial. 18 May 2026 11:08:11 EDT https://www.alzforum.org/news/research-news/plaque-removal-surrogate-statisticians-say-not-so-fast#comments https://www.alzforum.org/news/research-news/if-too-much-s-acylation-bad-too-little-may-be-well For some brain proteins, lingering lipid tags drive lipofuscin formation and neuronal overgrowth. For TDP-43, the same modification prevents aggregation. 15 May 2026 16:31:53 EDT https://www.alzforum.org/news/research-news/if-too-much-s-acylation-bad-too-little-may-be-well#comments https://www.alzforum.org/news/research-news/can-good-apoe-liver-offset-bad-apoe-brain When ApoE4 mice express ApoE3 Christchurch in hepatocytes, they have less amyloid pathology in the brain. 14 May 2026 16:58:57 EDT https://www.alzforum.org/news/research-news/can-good-apoe-liver-offset-bad-apoe-brain#comments https://www.alzforum.org/news/research-news/astrocyte-atlas-shows-transcription-factors-might-slow-alzheimers By overexpressing a library of transcription factors in the mouse brain, scientists pinpointed master regulators of different astrocyte functions and states. 14 May 2026 15:17:17 EDT https://www.alzforum.org/news/research-news/astrocyte-atlas-shows-transcription-factors-might-slow-alzheimers#comments