The Shadow Knows

2010-05-14T23:21:00.000-07:00

American Heart Association Journal, "Circulation", Publishes New Peer-Reviewed Study Involving Protandim(R)

American Heart Association Journal, "Circulation", Publishes New Peer-Reviewed Study Involving Protandim(R).

Study Concludes that Protandim Preserved Heart Function and Demonstrated Strong Cardioprotective Effects in an Animal Model of Lung Disease.

Osteopontin levels reduced by more than fifty percent; heart output preserved and cardiac fibrosis prevented in animals
SAN DIEGO, November third /Newswire-FirstCall/ -- LifeVantage Corporation (OTC Bulletin Board: LFVN), announced that in a peer-reviewed manuscript published in the prestigious American Heart Association journal, "Circulation".

Dr. Norbert Voelkel and researchers at Virginia Commonwealth University (VCU), demonstrated the ability of Protandim, the Company's patented dietary supplement, composed of five highly synergistic "indirect antioxidants", to protect the heart in a laboratory model of pulmonary hypertension in rats.

Pulmonary hypertension is a health condition characterized by high blood pressure in the circulation between the heart and lungs and can result in death due to right heart failure.

In this study, pulmonary hypertension was induced in the animals through a drug and by creating an oxygen-poor environment (hypoxia). Animals pre-treated with Protandim experienced strong cardioprotective effects. Protandim was shown to protect the heart by increasing the expression of protective genes and by preventing the formation of scar tissue, or fibrosis, in the heart.

The study showed that Protandim also prevented capillary loss in the heart muscle of the animals, preserving right heart function despite the continuing stress of pressure overload. Protandim also prevented the death of heart cells and significantly lowered osteopontin (OPN-1) levels by more than 50%.

Osteopontin is a factor that leads to scar tissue formation, a cause of heart failure. The researchers in this study described the ability of Protandim to effectively activate the transcription factor Nrf2, a signal to the cell's DNA to increase expression of a network of antioxidant, anti-inflammatory, and anti-fibrotic genes.

"We are encouraged by the results of this study, which was independently funded and independently conducted by Dr. Voelkel and his colleagues at VCU," stated David Brown, President & CEO of LifeVantage. "These results illustrate the unique antioxidant, anti-inflammatory, and anti-fibrotic properties of Protandim.

Scientists have long known of the involvement of oxidative stress in disease processes, and this study is a significant example of how oxidative stress affects susceptibility to right heart failure in animals. Although it would be premature to conclude that similar benefits would be seen in humans, these remarkable results open the door to the possibility of future research on pulmonary hypertension and Protandim in humans."

The study entitled "Chronic pulmonary artery pressure elevation is insufficient to explain right heart failure" was authored by Harm Bogaard, Ramesh Natarajan, Scott C. Henderson, Carlin Long, Donatas Kraskauskas, Lisa Smithson, Ramzi Ockaili, Joe M. McCord, and Norbert Voelkel was published online, with a print version to follow.

About Protandim

Protandim is a clinically proven supplement that provides substantial benefits for healthy aging. This patented indirect antioxidant therapy works in a very different way than conventional foods such as red wine, oranges, blueberries or other popular antioxidant supplements.

Unlike those types of products that have proven to be largely ineffective in reducing oxidative stress caused by free radicals, Protandim is an indirect antioxidant therapy, which stimulates the body's production of its own powerful antioxidant enzymes. Protandim works at the cellular level, triggering cells to naturally increase production of protective antioxidant enzymes such as superoxide dismutase (SOD), catalase, and glutathione synthase.

A peer-reviewed human clinical study showed that after Protandim was taken for 30 consecutive days, important biochemical markers of aging were decreased by an average of 40%. The study also reported that these markers of aging were reduced in the subjects taking Protandim to the level of a typical 20 year old.

Protandim is currently the subject of approximately 20 scientific studies at universities and research facilities. The nature and stages of the studies vary.

Under the Dietary Supplement Health and Education Act, Protandim is considered a "dietary supplement" and, as with all dietary supplements, Protandim is not intended for the prevention, diagnosis, treatment, mitigation or cure of any disease, including pulmonary hypertension or heart disease.

For more information about Protandim, visit www.live-young.ws for ABC Primetime interview of Dr Joe McCord

Oxidative Damage

Accumulation of Oxidative Damage May Lead to Cognitive Dysfunction.

In aerobic organisms the energy needed to fuel biological functions is produced in the mitochondria via the electron transport chain. In addition to energy, reactive oxygen species (ROS) are produced which have the potential to cause cellular damage. ROS can damage DNA, RNA, and proteins which theoretically contribute to the physiology of aging.

ROS are produced as a normal product of cellular metabolism. In particular, one major contributor to oxidative damage is hydrogen peroxide (H2O2) which is converted from superoxide that leaks from the mitochondria. Within the cell there is catalase and superoxide dismutase that help to minimize the damaging effects of hydrogen peroxide by converting it into oxygen and water, benign molecules, however this conversion is not 100% efficient, and residual peroxides persist in the cell.

While ROS are produced as a product of normal cellular functioning, excessive amounts can cause deleterious effects:

[1] Memory capabilities decline with age, evident in human degenerative diseases such as Alzheimer’s disease which is accompanied by an accumulation of oxidative damage.

Current studies demonstrate that the accumulation of ROS can decrease an organism’s fitness because oxidative damage is a contributor to senescence.

In particular, the accumulation of oxidative damage may lead to cognitive dysfunction as demonstrated in a study where old rats were given Protandim and then given cognitive tests, results showed that the rats performed better after receiving the metabolites, suggesting that the metabolites reduced oxidative damage and improved mitochondrial function.

[2] Accumulating oxidative damage can then affect the efficiency of mitochondria and further increase the rate of ROS production.

[3] The accumulation of oxidative damage and its implications for aging depends on the particular tissue type where the damage is occurring.

Additional experimental results suggest that oxidative damage is responsible for age related decline in brain functioning. Older gerbils were found to have higher levels of oxidized protein in comparison to younger gerbils. When old and young mice were treated with a spin trapping compound the level of oxidized proteins decreased in older gerbils but did not have an effect on younger gerbils. Additionally, older gerbils performed cognitive tasks better during treatment but ceased functional capacity when treatment was discontinued causing oxidized protein levels to increase. This lead researchers to conclude that oxidation of cellular proteins is potentially important for brain function .
Carney

For information on anti aging go to
http://live-young.ws
Juanita38@ymail.com
Juanita Buck-Butler: 254-541 2891his post

American Heart Association Journal, Circulation, Publishes New Peer-Reviewed Study Involving Protandim(R)

American Heart Association Journal, "Circulation", Publishes New Peer-Reviewed Study Involving Protandim(R).

Study Concludes that Protandim Preserved Heart Function and Demonstrated Strong Cardioprotective Effects in an Animal Model of Lung Disease.

Osteopontin levels reduced by more than fifty percent; heart output preserved and cardiac fibrosis prevented in animals
SAN DIEGO, November third /Newswire-FirstCall/ -- LifeVantage Corporation (OTC Bulletin Board: LFVN), announced that in a peer-reviewed manuscript published in the prestigious American Heart Association journal, "Circulation".

Dr. Norbert Voelkel and researchers at Virginia Commonwealth University (VCU), demonstrated the ability of Protandim, the Company's patented dietary supplement, composed of five highly synergistic "indirect antioxidants", to protect the heart in a laboratory model of pulmonary hypertension in rats.

Pulmonary hypertension is a health condition characterized by high blood pressure in the circulation between the heart and lungs and can result in death due to right heart failure.

In this study, pulmonary hypertension was induced in the animals through a drug and by creating an oxygen-poor environment (hypoxia). Animals pre-treated with Protandim experienced strong cardioprotective effects. Protandim was shown to protect the heart by increasing the expression of protective genes and by preventing the formation of scar tissue, or fibrosis, in the heart.

The study showed that Protandim also prevented capillary loss in the heart muscle of the animals, preserving right heart function despite the continuing stress of pressure overload. Protandim also prevented the death of heart cells and significantly lowered osteopontin (OPN-1) levels by more than 50%.

Osteopontin is a factor that leads to scar tissue formation, a cause of heart failure. The researchers in this study described the ability of Protandim to effectively activate the transcription factor Nrf2, a signal to the cell's DNA to increase expression of a network of antioxidant, anti-inflammatory, and anti-fibrotic genes.

"We are encouraged by the results of this study, which was independently funded and independently conducted by Dr. Voelkel and his colleagues at VCU," stated David Brown, President & CEO of LifeVantage. "These results illustrate the unique antioxidant, anti-inflammatory, and anti-fibrotic properties of Protandim.

Scientists have long known of the involvement of oxidative stress in disease processes, and this study is a significant example of how oxidative stress affects susceptibility to right heart failure in animals. Although it would be premature to conclude that similar benefits would be seen in humans, these remarkable results open the door to the possibility of future research on pulmonary hypertension and Protandim in humans."

The study entitled "Chronic pulmonary artery pressure elevation is insufficient to explain right heart failure" was authored by Harm Bogaard, Ramesh Natarajan, Scott C. Henderson, Carlin Long, Donatas Kraskauskas, Lisa Smithson, Ramzi Ockaili, Joe M. McCord, and Norbert Voelkel was published online, with a print version to follow.

About Protandim

Protandim is a clinically proven supplement that provides substantial benefits for healthy aging. This patented indirect antioxidant therapy works in a very different way than conventional foods such as red wine, oranges, blueberries or other popular antioxidant supplements.

Unlike those types of products that have proven to be largely ineffective in reducing oxidative stress caused by free radicals, Protandim is an indirect antioxidant therapy, which stimulates the body's production of its own powerful antioxidant enzymes. Protandim works at the cellular level, triggering cells to naturally increase production of protective antioxidant enzymes such as superoxide dismutase (SOD), catalase, and glutathione synthase.

A peer-reviewed human clinical study showed that after Protandim was taken for 30 consecutive days, important biochemical markers of aging were decreased by an average of 40%. The study also reported that these markers of aging were reduced in the subjects taking Protandim to the level of a typical 20 year old.

Protandim is currently the subject of approximately 20 scientific studies at universities and research facilities. The nature and stages of the studies vary.

Under the Dietary Supplement Health and Education Act, Protandim is considered a "dietary supplement" and, as with all dietary supplements, Protandim is not intended for the prevention, diagnosis, treatment, mitigation or cure of any disease, including pulmonary hypertension or heart disease.

For more information about Protandim, visit http://novus-ordo.ws for ABC Primetime interview of Dr Joe McCord

Oxidative Stress and Memory Loss

Accumulation of Oxidative Damage May Lead to Cognitive Dysfunction.

In aerobic organisms the energy needed to fuel biological functions is produced in the mitochondria via the electron transport chain. In addition to energy, reactive oxygen species (ROS) are produced which have the potential to cause cellular damage. ROS can damage DNA, RNA, and proteins which theoretically contribute to the physiology of aging.

ROS are produced as a normal product of cellular metabolism. In particular, one major contributor to oxidative damage is hydrogen peroxide (H2O2) which is converted from superoxide that leaks from the mitochondria. Within the cell there is catalase and superoxide dismutase that help to minimize the damaging effects of hydrogen peroxide by converting it into oxygen and water, benign molecules, however this conversion is not 100% efficient, and residual peroxides persist in the cell.

While ROS are produced as a product of normal cellular functioning, excessive amounts can cause deleterious effects:

[1] Memory capabilities decline with age, evident in human degenerative diseases such as Alzheimer’s disease which is accompanied by an accumulation of oxidative damage.

Current studies demonstrate that the accumulation of ROS can decrease an organism’s fitness because oxidative damage is a contributor to senescence.

In particular, the accumulation of oxidative damage may lead to cognitive dysfunction as demonstrated in a study where old rats were given Protandim and then given cognitive tests, results showed that the rats performed better after receiving the metabolites, suggesting that the metabolites reduced oxidative damage and improved mitochondrial function.

[2] Accumulating oxidative damage can then affect the efficiency of mitochondria and further increase the rate of ROS production.

[3] The accumulation of oxidative damage and its implications for aging depends on the particular tissue type where the damage is occurring.

Additional experimental results suggest that oxidative damage is responsible for age related decline in brain functioning. Older gerbils were found to have higher levels of oxidized protein in comparison to younger gerbils. When old mice were treated with Protandim the level of oxidized proteins decreased. Additionally, older gerbils performed cognitive tasks better during treatment but ceased functional capacity when treatment was discontinued causing oxidized protein levels to increase. This lead researchers to conclude that oxidation of cellular proteins is potentially important for brain function .
Carney

For information on anti aging go to
http://novus-ordo.ws
maxcom3@hotmail.com
Roy Butler: 512-234-5273

Who is Roy Butler?

Until 2005, I painted in the colonial town of San Miguel de Allende, located

in the mountains of central Mexico. I have had a fair amount of success as

an artist. I now reside in Temple, Texas. I have been active

Affiliate Marketing since 2001.

I was born in Fresno, California in 1932. I served as a Marine fighter pilot

during the Korean War. After leaving the service I joined Pan AM. I retired

in 1990 as the managing director of flight training and B747 Capt,. I then

started my 2nd career as a research scientist at University of Texas until

retiring and moving to San Miguel in 2000.

There's $Dough$ in them thar Cookies

2010-05-14T23:03:00.000-07:00

Tips to Help You Start a Home Cookie Business

Ask anyone and they will tell you how much they love homemade cookies. Packaged cookies simply are not the same. If you have great cookie making skills and love to spend your time baking, you may want to consider making money from it. Many people start their own businesses based around a hobby and these are the kind that stand a better chance to succeed. The following are 5 tips to help you start a home cookie business:

Do not start a home cookie business until you have contacted your state and your town to determine what type of business license you need. You will also need to contact your state’s Department of Health to register with them as a local baker. They have specific guidelines to follow to protect the health of anyone who eats the food you make.

When you start a home cookie business, you will need to invest in some baking supplies. Before you take the money out of your savings, do some research to find out if you qualify for any special government funding to help you get started.

You will also need to determine how you are going to sell them. Are you going to sell them locally only or do you plan to ship out cookies all over the country? The Internet makes anything possible.

Plan your marketing strategy. What do you plan on doing that is going to grab the attention of cookie lovers? If you are selling locally only, a simply flyer announcing your start up may be all that it takes. However, if you are selling on the Internet, as well, you will want to find out the best way to reach your potential customers.

Get creative with your cookies. While the chocolate chip may be a favorite, everyone likes to try something new. The more time you spend in product development is only going to help you to further your success.

You will also want to be creative when you package your cookies. This can help you brand your business and make your business stand out far above your competition.

prepare yourself and your business for the holidays. The orders you will get during the holiday season may be more than you can handle on your own and it is always best to have help readily available.

When you start a home cookie business, you will also need to make certain that all members of your family are on board. Your cooking may have an effect on where your kids do their homework and what time meals are served. Keeping them informed of what changes are likely to happen will make for a much smoother start up for you.

And if you can't sell them all break out a quart of milk and enjoy

Roy Butler

Check out Roy Butler

2010-05-14T18:31:00.001-07:00

I want you to take a look at: Roy Butler

2010-05-14T17:33:00.001-07:00

How to Start a Home Food Business

If you enjoy cooking, baking, or growing your own food, you may want to learn how to start a home food business. First, it will allow you the luxury of working from you home and second, it can help you to earn a pretty decent income. Many people prefer to buy their food locally and, if you can offer something unique, you may find people all over the country will want your food shipped to them.

If you are interested and want to start a home food business, the first thing you should do is practice. Spend a lot of time on what you plan to offer to your customers so that you can work out any issues that could arise. Set up a test for yourself to see how well you can meet deadlines. Does the food always come out the same or does the quality change when you are under pressure? This is where the practice comes into play. Remember, practice will make perfect.

Contact the state you live in, as well as your town, to ask whether you will need any special licenses. Many states will also require that you contact the Department of Health to set up an inspection for the area you will be doing your food preparation.

The next step is to create a business name for yourself and then create a business plan. This will help you to formalize all of the details, including what you will offer, your price points, how you plan to finance your operation, and how you plan to promote your business. Anyone who does not create this written business plan will immediately put their business at risk for the lack of organization. It will also put you out of the running if you need a business loan.

Prepare for your business by creating a website for your business, as well as business cards. If you plan to sell locally only, marketing could involve ads in the newspaper, on the radio, and even on the television. However, if you plan to ship the products outside your location, go wild with your online marketing strategy. You will find that press release marketing will be more than helpful and can get your business off to a great start.

Once you start marketing your business, be prepared. When you start a home food business and offer quality products, you could immediately receive a large amount of orders. Be prepared for this to happen, but most important, have fun with your new business. You will be getting paid for doing something that brings you joy.

Roy Butler

Just Cause 2 PS3 Gameplay FUNNY!!!!!!

2010-05-14T17:25:00.000-07:00

2010-05-14T16:15:00.000-07:00

2010-05-14T16:02:00.000-07:00

Welcome Fellow Americans,

The unanimous Declaration of the sovereign People of the united States of America to restore and reinhabit the free American republics, has now been submitted to our state governor(s) which has returned our Republic(s) to the People. If you are new or just checking us out, please consider becoming a supporter. Please, only make this decision after you have read and understand the ‘plan overview’ (link above).

For security reasons, no copies of the Official Declaration are available to the public at this time; however, you have every right to view the document. We will be posting it here once the time is right.

Your Support, Your Voice, Speaks Volumes! If you would like to be a part of, or be in support of, The Restore America Plan, please fill out the form below. By Filling out this form, you are taking a stand for Your Nation, Your Country, and All of The People of America.

We may not be able to contact you immediately; however by simply standing behind/with The Restore America Plan, you ARE supporting the RIGHTS, FREEDOMS, AND SOVEREIGNTY of the American People. This is the Change America has been waiting for and Deserves. Visit here often for updates, official news, and developments. You can contact us at: http://www.restoreamericaplan.net/

Thank You, and May Freedom Be Yours!

LifeVantage TrueTV - Watch. Learn. Share.

2010-05-14T15:54:00.000-07:00

LifeVantage TrueTV - Watch. Learn. Share.

Anti-Aging Products | Business Opportunity | LifeVantage Corporation (LFVN)

2010-05-14T15:51:00.000-07:00

Anti-Aging Products | Business Opportunity | LifeVantage Corporation (LFVN)

2010-02-19T08:07:00.000-08:00

Nine Biomarkers of Aging You Can Control Through Exercise

Research at the USDA Human Nutrition Research Center on Aging (HNRCA) shows that people can reverse many of the physiological declines associated with aging through regular aerobics, flexibility and strength training exercise. By making positive changes in you own “biomarkers” you can prolong vitality and prevent development of “sarcopenia”—weakening of the body’s muscles, loss of balance, reduced mobility and frailty.

Nine biomarkers you can change are:

Muscle Mass. No matter what your age, you can increase the strength and mass of your muscles through resistance training. Otherwise, muscle mass will decline, accelerating at an alarming rate after age 45.
Basal Metabolic Rate (BMR). BMR is the rate of your metabolism sitting still or resting. BMR declines starting kicking in at age 20. Every decade reduces the number of calories needed daily to maintain a constant body weight by roughly 100 calories. Since most people continue to eat the same amount of food (if not more) this is one of the reasons they get fat. Aerobic exercise will speed up your BMR. Do enough of it and you can eat like a 20-year-old!
Body Fat Percentage. Just as people with a greater ratio of muscle to fat enjoy a higher metabolism, the opposite is true. The fatter you get, the less efficient your ability to burn off calories. The best way to attack excess body fat is a combination of exercise and moderate calorie restriction. In other words: exercise more and eat less.
Aerobic Capacity. For healthy lungs, a strong heart and an effective vascular network, you need good aerobic capacity, which is the amount of oxygen your body can process within a given time. This capacity typically declines by 30-40% by age 65. Regular exercise can increase your aerobic capacity, but the positive change in older people comes almost entirely in the ability of muscles to utilize oxygen (“oxidative capacity”). Thus, you need strengthening exercises as well as aerobic exercises. When you build muscles you create more muscle cells to consume oxygen. The more your body demands oxygen, the greater you utilize it and the higher your aerobic capacity.
Blood-Sugar Tolerance. By age 70, some 30% of women and 20% of men have an abnormal glucose-tolerance curve, increasing their risk for Type II diabetes (if they don’t already have this). Factors related to glucose metabolism that you can control are: (1) Increase in body fat; (2) Diet high in saturated fat; and (3) Inactivity.
Total Cholesterol/HDL Ratio. To compute your total cholesterol to HDL ratio, you simply divide the total cholesterol number by the HDL-cholesterol number. Of course, it helps to know these numbers. For middle-aged and older men and women, the ratio goal should be 4.5 or lower.
LDL cholesterol can be lowered by the use of statins such as Atorvastatin or by supplements including niacin and red yeast rice. Or it can be lowered by reducing the amount of saturated fat in your diet. To increase HDL, however, you need to exercise. Aerobic exercise seems to be particularly effective for raising HDL.
Blood Pressure. Controlling blood pressure is absolutely vital. Regular, vigorous exercise is one of the best tools for preventing and even treating high blood pressure.
Bone Density. On average, a person loses 1% of bone mass per year. When this decline reaches the point where risk of bone fracture is substantial, we call it “osteoporosis.” The effectiveness of calcium supplements to fight this is the subject of much debate; however, the effectiveness of weight-bearing exercise is not. Stress repeatedly placed on your bones through exercise makes them grow. Any number of studies have show that a prolonged span of weight-bearing exercise including walking, running, or bicycling reduces the rate of bone loss. Research at Tufts University indicated that exercise also increases your body’s ability to absorb dietary calcium.
Internal Body Temperature. Thermoregulatory ability is one more thing that diminishes with age. You have a harder time cooling off when you’re hot or warming up when you’re cold. The reasons are complex, but include a requirement for a warmer internal body temperature before sweating sets in, dehydration caused by impaired kidneys, and a lower overall amount of sweating. By exercising on a regular basis, you sweat more, increase thirst and total body water content. Remind yourself to drink lots of water.

--David Bunnell

Stay Young and Live a Healthy Active Life

2010-01-08T23:07:00.000-08:00

2009-12-27T19:05:00.000-08:00

American Heart Association Journal, "Circulation", Publishes New Peer-Reviewed Study Involving Protandim(R)

American Heart Association Journal, Circulation, Publishes New Peer-Reviewed Study Involving Protandim(R)

Who is Roy Butler?

Until 2005, I painted in the colonial town of San Miguel de Allende, located

in the mountains of central Mexico. I have had a fair amount of success as

an artist. I now reside in Temple, Texas. I have been active

Affiliate Marketing since 2001.

I was born in Fresno, California in 1932. I served as a Marine fighter pilot

during the Korean War. After leaving the service I joined Pan AM. I retired

in 1990 as the managing director of flight training and B747 Capt,. I then

started my 2nd career as a research scientist at University of Texas until

retiring and moving to San Miguel in 2000.

2009-12-21T04:33:00.000-08:00

2009-12-10T15:56:00.000-08:00

Make Extra Money Starting Today

People are always asking how to make extra money. They are wanting to put some money into savings or pay down their debt. You have almost unlimited possibilities to make extra money even if do work full-time. The best way to make a secondary income is to do something you enjoy like a hobby and get paid for it.

Anyone that has a knack for selling items, or is a collector, or even someone just good with computers can sell on eBay. You can setup an eBay account and start selling items that are just laying around the house or stored in boxes that you never use anymore. People will be glad to take these items off your hands and you will gain cash for things you are allowing to collect dust.

You can put your hobby to work by getting a booth at the local fair or festival and selling your creations. Blankets, throws and wood carvings are good ideas of items to sell. Visiting a few festivals and fairs can give you a good idea of what sells well and where would be a good location for your booth.I f you are artistic you can do caricatures of people at festivals or in the park on the weekends. You can also paint murals or make paintings at home and sell them.

Who would not want a beautifully landscaped yard? If you have a green thumb then you can offer your services to others who don't. They would be glad to pay you for a nicely landscaped yard. You may be surprised at how much homeowners and businesses will pay for your services. If you prefer not to work in other people's yards then you could just grow your own plants and sell them at a local market. Fruits and veggies also sell well there.

If you are musically inclined you can give singing lessons or guitar lessons. Moms are always looking for someone to teach their kid how to play the piano. If you don't mind performing you could book gigs at weddings and other events.

If you want to make extra money then you have plenty of options to chose from. You can turn your hobby into your second income or you could just do a part time job that you like. Either way these will help you reach your financial goals.

Maximum Life Foundations

2009-12-10T09:55:00.000-08:00

Oxidative Damage

2009-12-09T08:50:00.001-08:00

Oxidative damage

Accumulation of oxidative damage may lead to cognitive dysfunction.

In aerobic organisms the energy needed to fuel biological functions is produced in the mitochondria via the electron transport chain. In addition to energy, reactive oxygen species (ROS) are produced which have the potential to cause cellular damage. ROS can damage DNA, RNA, and proteins which theoretically contributes to the physiology of ageing.
ROS are produced as a normal product of cellular metabolism. In particular, one major contributor to oxidative damage is hydrogen peroxide (H₂O₂) which is converted from superoxide that leaks from the mitochondria. Within the cell there is catalase and superoxide dismutase that help to minimize the damaging effects of hydrogen peroxide by converting it into oxygen and water, benign molecules, however this conversion is not 100% efficient, and residual peroxides persist in the cell. While ROS are produced as a product of normal cellular functioning, excessive amounts can cause deleterious effects.^[1] Memory capabilities decline with age, evident in human degenerative diseases such as Alzheimer’s disease which is accompanied by an accumulation of oxidative damage. Current studies demonstrate that the accumulation of ROS can decrease an organism’s fitness because oxidative damage is a contributor to senescence. In particular, the accumulation of oxidative damage may lead to cognitive dysfunction as demonstrated in a study where old rats were given Protandim and then given cognitive tests, results showed that the rats performed better after receiving the metabolites, suggesting that the metabolites reduced oxidative damage and improved mitochondrial function.^[2] Accumulating oxidative damage can then affect the efficiency of mitochondria and further increase the rate of ROS production.^[3] The accumulation of oxidative damage and its implications for aging depends on the particular tissue type where the damage is occurring. Additional experimental results suggest that oxidative damage is responsible for age related decline in brain functioning. Older gerbils were found to have higher levels of oxidized protein in comparison to younger gerbils. When old and young mice were treated with a spin trapping compound the level of oxidized proteins decreased in older gerbils but did not have an effect on younger gerbils. Additionally, older gerbils performed cognitive tasks better during treatment but ceased functional capacity when treatment was discontinued causing oxidized protein levels to increase. This lead researchers to conclude that oxidation of cellular proteins is potentially important for brain function .

Carney

Protandim - Reduce Oxidative Stress by 40%

2009-10-27T05:29:00.000-07:00

REDUCES OXIDATIVE
STRESS BY AN
AVERAGE OF 40%

Clinical Proof
The induction of human superoxide dismutase and catalase in vivo: A fundamentally new approach to antioxidant therapy, Free Radical Biology and Medicine (2006)
2006 Clinical Protandim Study (pdf)
The results of a peer-reviewed study (Free Radical Biology and Medicine, 2006) showed Protandim eliminates the age-related increase in cell aging factors.
In the clinical trials, blood samples from men and women, young and old, consistently demonstrated that after 30 days, taking one caplet a day, test subjects realized a 40 percent average decrease in TBARS—the progressive aging rate of a 20 year old.
When maintained for 120 days, Protandim significantly increased activity of SOD and CAT antioxidant enzymes by 54 percent, substantially increasing the body’s antioxidant defenses.*

Normal subjects before supplementation with Protandim showed an age-dependent increase in TBARS (blue circles). The levels of TBARS dropped an average of 40% (p<0.0001) after 30 days of Protandim supplementation (green circles), and the age-related increase in TBARS virtually disappeared. This effect (gray circles) was maintained at 120 days with continued Protandim use. Synergistic induction of heme oxygenase-1 by the components of an antioxidant supplement Protandim, Free Radical Biology and Medicine (2008) 2008 Clinical Protandim Study (pdf) Results of a new peer-reviewed study (Free Radical Biology & Medicine, on November 18, 2008) clearly demonstrate that Protandim produces a 300 percent increase in glutathione, which is a key antioxidant and anti-aging factor. In addition, the study shows that Protandim’s synergistic formulation provides more antioxidant power than any food or conventional supplement.

2009 Peer Reviewed Study from Louisiana State, PLoS ONE Journal. 2009 Louisiana State Peer Reviewed Study Peer Reviewed Study from Louisiana State University, "Protandim®, a Fundamentally New Antioxidant Approach in Chemoprevention Using Mouse Two-Stage Skin Carcinogenesis as a Model," Published in PLoS ONE Journal. PROTANDIM HAS BEEN ISSUED TWO PATENTS, IS AWAITING A THIRD AND HAS BEEN FEATURED ON ABC's PRIMETIME.

2006 Clinical Protandim Study (pdf) Protandim has been studied by numerous universities in their own funded trials because scientists who know about the true science of oxidative stress are so excited about the potential. These universities include:

University of Colorado
Denver Health Medical Center Children's Hospital, Denver
Virginia Commonwealth University
Colorado State University
University of Florida
University of Kentucky
University of Michigan
Louisiana State University
Ohio State University
Vanderbilt University
Glamorgan University, Wales
Sahlgrenska University Hospital, Goteborg, Sweden
University Hospital, Brno, Czech Republic
Mexican Institute of Social Security, Mexico City

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease

Exposing the Antioxidant Supplement Myth

2009-10-07T20:21:00.001-07:00

Exposing the Antioxidant Supplement Myth

Submitted by roybutler on Wed, 10/07/2009 - 21:33

Health

Below are some excerpts from CV#690.
Herbert V. The antioxidant supplement myth. Am J Clin Nutr
1994;60:157-8 The complete article is at http://www.victorherbert.com/AntioxidACN.htm#2.

The
nutrition buzzword for 1994 is antioxidant Every supplement so labeled is
seen as having only an upside and no down‚side. This is a myth. No supplement is
a pure antioxidant.

At the November 1ó3, 1993 Food and Drug
Administration (FDA) Conference on Antioxidant Vitamins in Cancer and
Cardiovascular Disease (1), there was essentially unanimous
agreement that vitamins C, E, and b-carotene
are mischaracterized by describing them solely as ìantioxidantsî (fighters
against harm‚ful free radicals). They in fact are redox agents, antioxidant in
some circumstances (often so in the physiologic quantities found in food), and
prooxidant (producing billions of harmful free radicals) in other circumstances
(often so in the pharmacologic quantities found in supplements).

Excessive antioxidant action can
adversely affect key physiological processes (1). Pharmacologic amounts of
ìantioxidantî vitamins have chemical actions that are neither antioxidant nor
prooxidant (1, 2). For example, protection by
pharmacologic amounts of vitamin E against heart attacks may have more to do
with the prohemorrhagic action of megadoses of vitamin E and, being
prohemorrhagic, in some circumstances vitamin E may promote excessive bleeding
(2, 3, 4).

Large doses of vitamin E enhance immune
activity and thus may promote progression of immune and autoimmune diseases (eg,
asthma, food allergy, diabetes, rheumatoid arthritis, multiple sclerosis, and
lupus) (5). Large
doses of vitamin C can promote kidney stones (2).

Vitamin C is especially dangerous in the
presence of high body iron stores, which make vitamin C violently prooxidant (1, 6, 7). For genetic reasons
(7), more than 10% of American whites and perhaps as many as
30% of American blacks have high body iron

___________________________________________________________________________________________

The induction of human superoxide dismutase and catalase in vivo: A fundamentally new approach to antioxidant therapy

The reason this article is so important is that the research by Dr. Joe McCord at the University of Colorado also supports the antioxidant myth theory. Dr McCord began research into free radical biology and medicine and led to his discovery of superoxide dismutase and catalase. He was nominated for four Nobel prizes. His research led to his invention of Protandim which has three patents.

Watch the interview of Dr. McCord on ABC Primetime: HERE

Protandim a composition consisting of extracts of five widely studied medicinal plants (Protandim) was administered to healthy human subjects ranging in age from 20 to 78 years. Individual ingredients were selected on the basis of published findings of induction of superoxide dismutase (SOD) and/or catalase in rodents in vivo, combined with evidence of decreasing lipid peroxidation. Each ingredient was present at a dosage sufficiently low to avoid any accompanying unwanted pharmacological effects.

Blood was analyzed before supplementation and after 30 and 120 days of supplementation (675 g/day). Erythrocytes were assayed for SOD and catalase, and plasma was assayed for lipid peroxidation products as thiobarbituric acid-reacting substances (TBARS), as well as uric acid, C-reactive protein, and cholesterol (total, LDL, and HDL). Beforesupplementation, TBARS showed a strong ge-dependent increase. After 30 days of supplementation, TBARS declined by an average of 40% ( p = 0.0001) and the age-dependent increase was eliminated. By 120 days, erythrocyte SOD increased by 30% ( p < 0.01) and catalase by 54% ( p < 0.002). We conclude that modest induction of the catalytic antioxidants SOD and catalase may be a much more effective approach than supplementation with antioxidants (such as vitamins C and E and reservitrol) that can, at best, stoichiometrically scavenge a very small fraction of total oxidant production.

Oxidative stress is now recognized to be associated with more than 200 diseases, as well as with the normal aging process. In nearly all cases it is not clear whether the role is a causative one or whether the oxidative damage is simply asequela of other types of tissue injury. The primary tools available to probe this question have been supplementation with exogenous antioxidants such as vitamins C and E, carotenoids, and a long list of other compounds capable of reacting stoichiometrically with reactive oxygen species such as superoxide and hydrogen peroxide. The results of studies with supplemental antioxidants have been quite disappointing overall. For example, a compelling amount of evidence has led to the ‘‘oxidative hypothesis’’ of atherosclerosis [1,2], yet randomized, double-blind, placebo-controlled studies such as the HOPE and HOPE-TOO trials have concluded that vitamin E supplementation does not prevent cancer or major cardiovascular events and may, in fact, increase the risk for heart failure [3,4]. A similar situation exists for diabetes, in that despite the undeniable presence of substantial oxidative stress, attempts totreat the disease by supplementation with antioxidants have failed to produce any significant improvement [5].

Because polyunsaturated fatty acids are easy targets for oxidants, and because the process of lipid peroxidation is, once initiated, a self-sustaining free radical chain process, the accumulation of lipid peroxidation products provides the most
common biochemical marker of oxidative stress. There is strong correlation between thiobarbituric acid-reactive substances (TBARS) as a marker of lipid peroxidation and products that reflect oxidative damage to DNA [6]. However, in normal healthy men who have low intake of fruits and vegetables, and who might be further stressed by smoking, and who have measurable levels of oxidative stress, a moderate supplement of vitamins E, C, and folic acid produced no alteration in measures of oxidant damage [7]. Similarly, studies that have used
supplementation with a concentrate of fruits and vegetables [8] or the daily intake of 600 g of fruits and vegetables [9] have produced no effects on markers of oxidative damage to lipids or DNA. Thus, reasonable intakes of exogenous
stoichiometric scavengers of oxidants fail to inhibit lipid peroxidation significantly.This study has taken a different approach: the induction of endogenous antioxidant enzymes. The antioxidant enzymes superoxide dismutase (SOD) and catalase, by virtue of their ability to catalyze the disproportionation reactions of their substrates superoxide radical and hydrogen peroxide, respectively, have an enormous theoretical advantage over exogenous
antioxidants that are stoichiometrically consumed. There are published reports of at least 30 different botanical extracts or purified phytochemicals that when ingested by mammals result in increased activities of SOD and catalase, with
concomitant decreases in plasma TBARS indicative of decreased lipid peroxidation, which has come to be synonymous with decreased oxidative stress. It is assumed that these substances act primarily by direct induction of SOD and catalase and that this results in decreased oxidative stress.

For more information about these studies and others that support the invention Protandim contact Roy Butler at roy@live-young.ws

Also listen to the interview on WOR radio of Dr. Carlon Colker

http://www.facebook.com/ext/share.php?sid=121275198724&h=ccRcE&u=utBEz&ref=share

Carlon Colker is the head trainer for Shaqiulle Oneal, UFC
Champion Quinton "Rampage" Jakson, Diego Sanchez, Andre Aggasi, just
to name a few and many more high profile athletes, celebrities and world
olympians. I spoke with Dr. Colker in San
Diego at the ribbon cutting event for LifeVantage. He
told me that he's definitely recommending Protandim to all
his athletes and clients. He stated that, the less oxidative stress we have in
our bodies, the faster our bodies can recover from intense workouts, games,
matches and performances!!

roybutler's blog

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Dr. Perlmutter, Dr. McCord, Montel Williams

2009-10-01T21:01:00.001-07:00

Dr. Perlmutter, Dr. McCord, Montel Williams

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Retired Pilot Steering Entrepreneurs Toward New Adventure

2009-10-01T14:21:00.000-07:00

Roy Butler knows a bunch of baloney when he sees it. That’s why he was so turned off by all the so-called get-rich schemes inundating the Internet.

It seemed like stretching the truth had become a way of life on the web. That’s when Roy, a retired airline pilot and research scientist at the University of Texas, decided to launch his own site with not one bit of baloney in sight. It’s called Roy-LifeVantage.com, and it’s the one place entrepreneurs need to go to get the straight scoop on how to start a successful home business.

Roy selected the businesses on his site for a few reasons: ease of operation, professional support, and their ability to make money. If it doesn’t pass Roy’s test for legitimacy, it doesn’t end up on his website.

"As long as you have a zest for life and a real desire to help others you're never too old to start on a new adventure," Roy states. “The Internet offers anyone the amazing opportunity to make a nice income in your free time.”

In addition to the businesses, Roy has also included training materials that can help even those with little experience in Internet marketing launch a successful business. One such educational resource is “Dotcomology: The Science of Making Money Online” by renowned marketer Stone Evans. The e-book is free to download from Roy’s site without obligation.

Roy’s also offering a free one-year subscription to his newsletter, Home Business Tips. The newsletter has practical, useable information that can help any home business thrive.

For more information about starting a new adventure with a home business, go to: http://Roy-LifeVantage.com.

2009-09-30T20:32:00.000-07:00

The Law of Attraction

I want to talk to you about “The Secret.” I want to share some of my thoughts with you. If you have not read it, this book is about the law of attraction and how like attracts like. You not only become what you think about but your thoughts create your life. I must tell you this is true whether you attribute it to God, faith or the power of the universe.

I have seen this in the 77 years of my life over and over. The key is to focus on what you want, not what you don't want. I have focused my thoughts on success and it happened to the tune of earning more than $200,000 in 1990. Not only did I dream about success but I created a mind set of already considering myself to be successful. This is the essence of The Secret discussed in this book and the movie. As long as you have a zest for life and a real desire to help others you're never too old to start on a new adventure. The Internet offers anyone the amazing opportunity to make a nice income in your free time.

If you want to succeed in your business then focus on success instead of not failing. The problem is most focus on not failing. There is a difference. They think about how they are not making sales and how their business is not going anywhere. They expect failure and what do you think they are doing to get. Start focusing on what you want, not what you don't. Visualize commission checks coming in and expect to succeed.

You are doing a lot of marketing with the coop, article marketing and so on - I urge you to visualize these things working up for you a mountain of sales and expect it to happen and then have unwavering faith. I know many of you are trying to get your business off the ground and are dreaming of owning a successful business earning more than six figures and many of you are already doing that and are seeking to grow your business to a new level.

Several years ago I was just getting started and I read a business book called "If You Don't Have Big Breasts Put Ribbons On Your Pig tails." It is a book written by a billionaire business person and she says in there that when she was just starting out she spend a lot of money to buy a fancy new coat. This coat was way out of her price range but it made in feel successful and this caused her to create a mindset of success that focused on living up to the image of herself as a successful business person.

In order to create your own success I challenge you to consider yourself already successful. Do something that makes you feel successful in your business and use that to motivate you and empower your thoughts. If you can learn to do this your success will be just around the corner.

During the movie and book The Secret they talk about how many people try using The Secret and then when it does not work for them they give up and say "This doesn't work." That is similar to a story in the book Think and Grow Rich where the author talks about a man who purchased an old goldmine. He spent several years mining and not finding anything. Finally he gave up and sold the mine to someone for very little money. The new owner had an engineer study the mine and then started drilling and within a few feet struck gold.
Can you imagine ... the prior owner gave up within only a few feet from his dream?

I have seen this in my own life. There have been so many times I came close to giving up only shortly before I realized a great success. I challenge you to keep going after your dream and believe that it is within your reach. This applies to financial success, business, relationships, love and health.

Most people, average people try this business for about a month and when they don't make it they quit and have all kinds of excuses. Those who stick it out and market their business day in day out determined to succeed are the ones that make it. I have seen this to be true time and time again.
Roy Butler

Business Ideas That Can Put You On The Road To A Six Figure Income!

2009-09-28T01:43:00.000-07:00

Have you always dreamed of starting your own business, but have never followed through with it? Each day countless people toy around with the idea of becoming a business owner, but some of the everyday things in life hold them back. Most people can't afford to simply quit job and start a business, but there are ways you can start a business in your spare time and build it until you can afford to quit your job. Business ideas are all around you choosing the right one can easily net you a six figure income this year!

Starting a business in your part time requires you to begin with business ideas that aren't going to require you to be there all hours of the day. This means it's probably not going to be wise to open a store unless you can afford to pay people to run it while you go to work. However, you can easily open an online store. Online stores are great because the Internet is working for you 24 hours a day. They allow you to lead your life and work on them only a few hours a day. You can sell whatever you want and as long as you learn how to advertise properly and drive people to your website you'll succeed. I am 77 and have retired from two jobs

but my passion for helping people has kept me active and healthy. If you are interested in the secret to aging and still having a passion for life, check it out HERE.

More great business ideas fall into the category of freelance work. People earn a lot of money with freelance work and there are multiple jobs available. You could be a freelance writer, photographer, graphic artist, and even a virtual assistant. Everyone has some skill that can they can use to make a living off of. The great thing about doing freelance work is that it doesn't usually cost you a lot of money to start a business.

You can also turn hobbies into business ideas. Think about the things you love to do and what type of businesses you can make around them. For example, if you hobby is scrapbooking, you can easily make a business as a scrapper for hire. People love handmade items, but often they don't have the time or energy to create them. I personally love art and have been painting since 1963, and been financially successful at it because it is something I love to do. If you have an open mind, you can easily make any skills you have into a successful business. Before you know it, you'll be not only making six figures a year, but will have complete control of your personal life as well. If you need help in getting your business going visit my other blog

http://www.roy-lifevantage.com/blog/

Best regards
Roy Butler

Hello again and welcome back to roys-shadow.blogspot

2009-09-28T00:32:00.000-07:00

I've just launched my new blog! Stay tuned for the latest updates and information about starting a and succeeding with an Internet home business.

I learned how to launch my blog from Plug-In Profit Site training at: http://www.PlugInProfitSite.com/main-27913

Check it out!

Sincerely,

Roy Butler
http://www.Roy-LifeVantage.com

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Dr. Perlmutter, Dr. McCord, Montel Williams

Retired Pilot Steering Entrepreneurs Toward New Adventure

Business Ideas That Can Put You On The Road To A Six Figure Income!

Hello again and welcome back to roys-shadow.blogspot