tag:blogger.com,1999:blog-5404899497767286432024-10-06T20:24:47.314-07:00Sharing information about molecular medicine and genetic diseaseUnknownnoreply@blogger.comBlogger106125tag:blogger.com,1999:blog-540489949776728643.post-57841690465899512252011-05-11T14:11:00.000-07:002011-05-11T14:11:00.750-07:00

1Department of Microbiology and Immunology and Institute for Cellular Therapeutics, University of Louisville School of Medicine, 570 South Preston Street, Louisville, KY 40202, USA.Monophosphoryl lipid A (MLA), a nontoxic derivative of the endotoxin lipopolysaccharide (LPS), has been approved in the United States for use as a vaccine adjuvant. LPS and MLA are ligands of Toll-like receptor 4 (TLR4

Unknownnoreply@blogger.com1tag:blogger.com,1999:blog-540489949776728643.post-3011927664809565922011-05-11T10:21:00.000-07:002011-05-11T10:21:00.524-07:00

J Clin Invest. doi:10.1172/JCI45235. Copyright © 2011, The American Society for Clinical Investigation. Margalida Rotger1, Judith Dalmau2, Andri Rauch3, Paul McLaren4, Steve Bosinger5, Raquel Martinez1, Netanya G. Sandler6, Annelys Roque6, Julia Liebner6, Manuel Battegay7, Enos Bernasconi8, Patrick Descombes9, Itziar Erkizia2, Jacques Fellay1, Bernard Hirschel10, Jose M. Miró11, Eduard Palou12,

Unknownnoreply@blogger.com0tag:blogger.com,1999:blog-540489949776728643.post-60847604263079938542011-05-11T07:16:00.000-07:002011-05-11T07:16:00.217-07:00

J Clin Invest. doi:10.1172/JCI46277. Copyright © 2011, The American Society for Clinical Investigation. Qing-Jun Zhang1, Hou-Zao Chen2, Lin Wang1, De-Pei Liu2, Joseph A. Hill1 and Zhi-Ping Liu1 1Departments of Internal Medicine and Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas, USA. 2National Laboratory of Medical Molecular Biology, Institute of Basic Medical

Unknownnoreply@blogger.com0tag:blogger.com,1999:blog-540489949776728643.post-482347403653553162011-05-11T02:51:00.000-07:002011-05-11T02:51:00.506-07:00

Clinical Science (2011) Immediate Publication, doi:10.1042/CS20110032 Hypoxic exercise training promotes anti-tumor cytotoxicity of natural killer cells in menJong-Shyan Wang and Tzu-Pin WengGraduate Institute of Rehabilitation Science, Chang Gung University, Tao-Yuan 333, Taiwan. s5492@mail.cgu.edu.twThe cytotoxic functions of natural killer cells (NKs) are critical in enabling the immune system

Unknownnoreply@blogger.com0tag:blogger.com,1999:blog-540489949776728643.post-57394013750941305522011-05-10T22:13:00.000-07:002011-05-10T22:13:00.504-07:00

J Clin Invest. doi:10.1172/JCI45109. Copyright © 2011, The American Society for Clinical Investigation. Xiaohua Ni1, Yonggang Zhang2, Judit Ribas1, Wasim H. Chowdhury1, Mark Castanares1, Zhewei Zhang2, Marikki Laiho2, Theodore L. DeWeese1,2,3 and Shawn E. Lupold1,2,3 1James Buchanan Brady Urological Institute, 2Department of Radiation Oncology and Molecular Radiation Sciences, and 3Sidney Kimmel

Unknownnoreply@blogger.com0tag:blogger.com,1999:blog-540489949776728643.post-26260151458013549692011-05-10T17:41:00.000-07:002011-05-10T17:41:00.265-07:00

J Clin Invest. doi:10.1172/JCI45027. Copyright © 2011, The American Society for Clinical Investigation. Yingjie Wu1, Chengyu Liu2, Hui Sun1, Archana Vijayakumar1, Pejman Raeisi Giglou1, Ruifang Qiao1, Joshua Oppenheimer1, Shoshana Yakar1 and Derek LeRoith1 1Division of Endocrinology, Diabetes and Bone Disease, Department of Medicine, and Department of Oncological Sciences, Mount Sinai School of

Unknownnoreply@blogger.com0tag:blogger.com,1999:blog-540489949776728643.post-40383482718357808292011-05-10T14:40:00.000-07:002011-05-10T14:40:00.620-07:00

J Clin Invest. doi:10.1172/JCI44932. Copyright © 2011, The American Society for Clinical Investigation. Estibaliz Lazaro1, Carl Kadie2, Pamela Stamegna1, Shao Chong Zhang1, Pauline Gourdain1, Nicole Y. Lai1, Mei Zhang1, Sergio A. Martinez1, David Heckerman3 and Sylvie Le Gall1 1Ragon Institute of MGH, MIT and Harvard, Massachusetts General Hospital and Harvard Medical School, Boston,

Unknownnoreply@blogger.com0tag:blogger.com,1999:blog-540489949776728643.post-3213950931985932722011-05-10T10:07:00.000-07:002011-05-10T10:07:00.213-07:00

J Clin Invest. doi:10.1172/JCI46405. Copyright © 2011, The American Society for Clinical Investigation. Alison Sleigh1, Philippa Raymond-Barker2, Kerrie Thackray3, David Porter4, Mensud Hatunic3, Alessandra Vottero5, Christine Burren6, Catherine Mitchell7, Martin McIntyre8, Soren Brage9, T. Adrian Carpenter1, Peter R. Murgatroyd2, Kevin M. Brindle10, Graham J. Kemp11, Stephen O’Rahilly3, Robert K

Unknownnoreply@blogger.com0tag:blogger.com,1999:blog-540489949776728643.post-23039701626264708262011-05-10T06:31:00.000-07:002011-05-10T06:31:00.076-07:00

J Clin Invest. doi:10.1172/JCI45403. Copyright © 2011, The American Society for Clinical Investigation. Myat Lin Oo1, Sung-Hee Chang1, Shobha Thangada2, Ming-Tao Wu2, Karim Rezaul2, Victoria Blaho1, Sun-Il Hwang3, David K. Han2 and Timothy Hla1 1Center for Vascular Biology, Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, Cornell University, New York, New York, USA.

Unknownnoreply@blogger.com0tag:blogger.com,1999:blog-540489949776728643.post-20584676045137688692011-05-10T02:56:00.000-07:002011-05-10T02:56:01.125-07:00

J Clin Invest. doi:10.1172/JCI46102. Copyright © 2011, The American Society for Clinical Investigation. Lukas Baitsch1, Petra Baumgaertner1, Estelle Devêvre1, Sunil K. Raghav2, Amandine Legat1, Leticia Barba1, Sébastien Wieckowski3, Hanifa Bouzourene3, Bart Deplancke2, Pedro Romero4, Nathalie Rufer1,3 and Daniel E. Speiser1 1Clinical Tumor Immune-Biology Unit, Ludwig Institute for Cancer Research

Unknownnoreply@blogger.com0tag:blogger.com,1999:blog-540489949776728643.post-34302025268915445522011-05-09T22:46:00.000-07:002011-05-09T22:46:00.121-07:00

Sunday, May 08, 2011ROCHESTER, Minn. — Mayo Clinic researchers have designed a new tool for identifying protein function from genetic code. A team led by Stephen Ekker, Ph.D., succeeded in switching individual genes off and on in zebrafish, then observing embryonic and juvenile development. The study appears in the journal Nature Methods. The work could help shed light on health-related problems

Unknownnoreply@blogger.com0tag:blogger.com,1999:blog-540489949776728643.post-45323649416913281932011-05-09T18:42:00.001-07:002011-05-09T18:42:07.909-07:00

Clinical Science (2011) Immediate Publication, doi:10.1042/CS20110072 Chronic HgCl2 treatment increases vasoconstriction induced by electrical field stimulation. Role of adrenergic and nitrergic innervationJavier Blanco-Rivero, Lorena B Furieri, Dalton V Vassallo, Mercedes Salaíces and Gloria BalfagónFisiología, Facultad de Medicina. Universidad Autónoma de Madrid, Madrid, Madrid 28029, Spain.

Unknownnoreply@blogger.com0tag:blogger.com,1999:blog-540489949776728643.post-39494023268160112762011-05-04T20:19:00.000-07:002011-05-04T20:19:29.743-07:00

Bioinformatician A person that uses mathematics and statistics to interpret the large amount of computer-generated data from genetic/genomic research or clinical studies. Bioinformatics A modern field of science that combines biology, computer science, and information technology. Bioinformatics is essential to better understanding and analyzing the large amounts of genetic and

Unknownnoreply@blogger.com0tag:blogger.com,1999:blog-540489949776728643.post-72600578696991019702011-05-04T02:41:00.000-07:002011-05-04T02:41:00.961-07:00

The U.S. Federal Court of Appeals has overturned an August 2010 ban on federal funding of embryonic stem cell research, paving the way for broader exploration of how stem cells function and how they can be harnessed to treat a wide range of currently incurable diseases. The ruling has been welcomed by the Obama Administration, which attempted to lift the ban in 2009, and by the nation's top

Unknownnoreply@blogger.com2tag:blogger.com,1999:blog-540489949776728643.post-13024567330746577172011-05-03T22:03:00.000-07:002011-05-03T22:03:00.064-07:00

Researchers have developed an effective technique that uses gene therapy on stem cells to correct chronic granulomatous disease (CGD) in cell culture, which could eventually serve as a treatment for this rare, inherited immune disorder, according to a study published in Blood, the Journal of the American Society of Hematology. CGD prevents neutrophils, a type of white blood cell of the immune

Unknownnoreply@blogger.com4tag:blogger.com,1999:blog-540489949776728643.post-8611510441307620862011-05-03T17:31:00.000-07:002011-05-03T17:31:00.137-07:00

Stem cell research began with a goal of being able to cure persons based on their own unique genetic make-up and healing inefficiencies by using harvested cells. This week, a federal appeals court said the Obama led federal government can continue to fund research involving human embryonic stem cells. The 2-1 ruling overturned a trial judge's injunction in August 2010 that barred funding for the

Unknownnoreply@blogger.com0tag:blogger.com,1999:blog-540489949776728643.post-84616537373144215912011-05-03T14:30:00.000-07:002011-05-03T14:30:00.282-07:00

Researchers in the Faculty of Medicine & Dentistry at the University of Alberta have made an important discovery that provides a new understanding of how our immune system "learns" not to attack our own body, and this could affect the way doctors treat patients with autoimmune diseases and cancer. When patients undergo chemotherapy for cancer or as part of experimental therapies to treat

Unknownnoreply@blogger.com0tag:blogger.com,1999:blog-540489949776728643.post-16611993997750417072011-05-03T09:57:00.000-07:002011-05-03T09:57:00.282-07:00

In Correspondence published Online First and an upcoming Lancet, Japanese experts suggest that blood products be taken from workers dealing with the ailing Fukushima Nuclear Facility-so that, should they accidently be exposed to high and health-damaging doses of radiation during the clean-up operation, they will be able to receive treatment by undergoing stem cell transplanation using their own

Unknownnoreply@blogger.com0tag:blogger.com,1999:blog-540489949776728643.post-6508158046515364392011-05-03T06:21:00.000-07:002011-05-03T06:21:00.372-07:00

In a paper published in the April 25 early online edition of the Proceedings of the National Academy of Sciences, researchers at the University of California, San Diego School of Medicine, the Gladstone Institutes in San Francisco and colleagues report a game-changing advance in stem cell science: the creation of long-term, self-renewing, primitive neural precursor cells from human embryonic stem

Unknownnoreply@blogger.com0tag:blogger.com,1999:blog-540489949776728643.post-61413364994669152632011-05-03T02:46:00.000-07:002011-05-03T02:46:00.148-07:00

Study shows, for the first time, the successful reprogramming of diseased human hepatocytes into induced pluripotent stem cells (iPSC).1 Results also found differentiation into mature hepatocytes was more efficient than that with fibroblast-derived iPSCs. The generation of diseased hepatocyte-derived human iPSC lines provides a good basis for the study of liver disease pathogenesis. Such

Unknownnoreply@blogger.com0tag:blogger.com,1999:blog-540489949776728643.post-56009234252982003352011-05-02T22:36:00.000-07:002011-05-02T22:36:00.140-07:00

Dr. Paul Sanberg, Distinguished University Professor and senior associate vice president for research and innovation at the University of South Florida, received the Everfront Award at the 4th Pan Pacific Symposium on Stem Cell and Cancer Research held earlier this month in Taichung, Taiwan. The Everfront Award honors outstanding research contributions in stem cell and cancer research, including

Unknownnoreply@blogger.com0tag:blogger.com,1999:blog-540489949776728643.post-22985822914488367302011-05-02T18:32:00.000-07:002011-05-02T18:33:02.788-07:00

to make, stem cells have a process to "decide" whether to transform into a specific cell type or to stay flexible, a state that biologists call "pluripotency." Using a technology he invented, Brown researcher William Fairbrother and colleagues have discovered new molecular interactions in the process that will help regenerative medicine researchers better understand pluripotency. In a paper

Unknownnoreply@blogger.com0tag:blogger.com,1999:blog-540489949776728643.post-19532061351681629822011-04-27T03:10:00.000-07:002011-04-27T03:10:00.901-07:00

Main Category: Stem Cell ResearchAlso Included In: Transplants / Organ DonationsArticle Date: 19 Apr 2011 - 2:00 PDT window.fbAsyncInit = function() { FB.init({ appId: 'aa16a4bf93f23f07eb33109d5f1134d3', status: true, cookie: true, xfbml: true, channelUrl: 'http://www.medicalnewstoday.com/scripts/facebooklike.html'}); }; (function() { var e = document.createElement('script'); e.async = true;

Unknownnoreply@blogger.com0tag:blogger.com,1999:blog-540489949776728643.post-59440773595765270792011-04-26T23:00:00.000-07:002011-04-26T23:00:06.530-07:00

In order to prepare for any future stem cell transplants required as a result of accidental exposure to high doses of radiation during clean up, Fukushima workers have been advised to store their own blood now, Japanese experts wrote in the medical journal The Lancet today. Undergoing stem cell transplantation using their own cells - termed autologous transplant - is an option that should be

Unknownnoreply@blogger.com0tag:blogger.com,1999:blog-540489949776728643.post-13424995370299980522011-04-26T18:56:00.001-07:002011-04-26T18:56:18.795-07:00

A scientist at the Gladstone Institutes has made two significant stem-cell discoveries that advance medicine and human health by creating powerful new approaches for using stem cells and stem-cell-like technology. In two papers published on April 25 in the Proceedings of the National Academy of Sciences, Sheng Ding, PhD, reveals novel and safer methods not only for transforming embryonic stem

Unknownnoreply@blogger.com0