<?xml version='1.0' encoding='UTF-8'?><?xml-stylesheet href="http://www.blogger.com/styles/atom.css" type="text/css"?><feed xmlns='http://www.w3.org/2005/Atom' xmlns:openSearch='http://a9.com/-/spec/opensearchrss/1.0/' xmlns:blogger='http://schemas.google.com/blogger/2008' xmlns:georss='http://www.georss.org/georss' xmlns:gd="http://schemas.google.com/g/2005" xmlns:thr='http://purl.org/syndication/thread/1.0'><id>tag:blogger.com,1999:blog-763914643556275777</id><updated>2024-09-01T23:12:05.754-07:00</updated><category term="Breast"/><category term="Cancer"/><category term="Awareness"/><category term="Month"/><category term="Women"/><category term="Cancers"/><category term="Treatment"/><category term="human"/><category term="Detection"/><category term="Diagnosis"/><category term="EarlyStage"/><category term="Growth"/><category term="Radiation"/><category term="Study"/><category term="cells"/><category term="expression"/><category term="progression"/><category term="therapy"/><category 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href='http://www.blogger.com/feeds/763914643556275777/posts/default?start-index=26&amp;max-results=25&amp;redirect=false'/><author><name>Anonymous</name><uri>http://www.blogger.com/profile/14799558047407972898</uri><email>noreply@blogger.com</email><gd:image rel='http://schemas.google.com/g/2005#thumbnail' width='16' height='16' src='https://img1.blogblog.com/img/b16-rounded.gif'/></author><generator version='7.00' uri='http://www.blogger.com'>Blogger</generator><openSearch:totalResults>87</openSearch:totalResults><openSearch:startIndex>1</openSearch:startIndex><openSearch:itemsPerPage>25</openSearch:itemsPerPage><entry><id>tag:blogger.com,1999:blog-763914643556275777.post-8464301980632062387</id><published>2010-11-14T21:58:00.000-08:00</published><updated>2010-11-14T21:58:00.552-08:00</updated><category scheme="http://www.blogger.com/atom/ns#" term="ACRIN"/><category scheme="http://www.blogger.com/atom/ns#" term="Breast"/><category scheme="http://www.blogger.com/atom/ns#" term="EUSOBI"/><category scheme="http://www.blogger.com/atom/ns#" term="exams"/><category scheme="http://www.blogger.com/atom/ns#" term="facilities"/><category scheme="http://www.blogger.com/atom/ns#" term="performing"/><category scheme="http://www.blogger.com/atom/ns#" term="requirements"/><category scheme="http://www.blogger.com/atom/ns#" term="technical"/><title type='text'>Maj. of comm. facilities performing breast MRI exams meet ACRIN and EUSOBI technical requirements</title><content type='html'> &lt;A onclick=&quot;window.opener.focus();return false;&quot; href=&quot;http://www.eurekalert.org/pubnews.php&quot;&gt;&lt;IMG border=0 alt=&quot;[ Back to EurekAlert! ]&quot; align=right src=&quot;/back2e.gif&quot; width=140 height=36&gt;&lt;/A&gt; &lt;STRONG class=relemb&gt;Public release date: 1-Nov-2010&lt;/STRONG&gt;&lt;BR&gt;[ | &lt;A onclick=&quot;visit(&#39;http://www.eurekalert.org/emailrelease.php?file=acor-moc102910.php&#39;)&quot; href=&quot;about:blank#&quot; target=_self&gt;E-mail&lt;/A&gt; | &lt;A onmouseover=&quot;return addthis_open(this, &#39;&#39;, &#39;[URL]&#39;, &#39;[TITLE]&#39;)&quot; onmouseout=addthis_close() onclick=&quot;return addthis_sendto()&quot; href=&quot;http://www.addthis.com/bookmark.php?v=20&quot;&gt;&lt;IMG border=0 alt=Share src=&quot;/shareicon.gif&quot; width=11 height=11&gt; Share&lt;/A&gt; ] &lt;P&gt;Contact: Heather Curry&lt;BR&gt;&lt;A href=&quot;mailto:hcurry@acr.org&quot;&gt;hcurry@acr.org&lt;/A&gt;&lt;BR&gt;703-390-9822&lt;BR&gt;&lt;A href=&quot;http://www.arrs.org/&quot;&gt;American College of Radiology / American Roentgen Ray Society&lt;/A&gt; &lt;BR&gt;&lt;P&gt;An overwhelming majority of Breast Cancer Surveillance Consortium (BCSC) facilities performing breast magnetic resonance imaging (MRI) in the U.S. are up-to-par with American College of Radiology Imaging Network (ACRIN) and European Society of Breast Imaging (EUSOBI) technical standards and requirements, according to a study in the November issue of the Journal of the American College of Radiology (&lt;A href=&quot;http://www.jacr.org/&quot;&gt;www.jacr.org&lt;/A&gt;). The BCSC is a collaborative effort to improve breast cancer research. It consists of five mammography registries and two affiliated sites with linkages to pathology and/or tumor registries. &lt;/P&gt;&lt;P&gt;As its use has expanded, breast MRI has been adopted by community practice facilities, where most women undergo breast imaging in the U.S. However, little is known about the technical quality of MRI performed at these facilities. &lt;/P&gt;&lt;P&gt;&quot;The purpose of our study was to evaluate breast MRI equipment and acquisition techniques currently used among a variety of community practice facilities across the U.S., using data from the BCSC, and to determine the compliance with current minimum standards specified by the ACRIN Trial 6667 and the EUSOBI,&quot; said Wendy B. DeMartini, MD, lead author of the study.&lt;/P&gt;&lt;P&gt;BCSC facilities performing breast MRI were identified and queried by survey regarding breast MRI equipment and technical parameters. Results tallied and percentages of facilities meeting ACRIN and EUSOBI standards were calculated. From 23 facilities performing breast MRI, results were obtained from 14 facilities. &quot;Adherence to minimum standards for breast MRI equipment across community practice facilities was excellent. Compliance with equipment recommendations of 1.5T field strength MRI scanners was 94 percent and all scanners employed a dedicated breast coil, as recommended by both ACRIN and the EUSOBI,&quot; said DeMartini. &lt;/P&gt;&lt;P&gt;&quot;Breast MRI is highly sensitive, but is a complex tool for which appropriate use requires optimization of multiple technical parameters which can be a tedious process. However, we found that nearly all facilities surveyed in the U.S. met ACRIN and EUSOBI standards for breast MRI equipment,&quot; said DeMartini. &lt;/P&gt;&lt;P&gt;The November issue of JACR is an important resource for radiology and nuclear medicine professionals as well as students seeking clinical and educational improvement.&lt;/P&gt;&lt;P&gt;For more information about JACR, please visit &lt;A href=&quot;http://www.jacr.org/&quot;&gt;www.jacr.org&lt;/A&gt;.&lt;/P&gt;&lt;P&gt;To receive an electronic copy of an article appearing in JACR or to set up an interview with a JACR author or another ACR member, please contact Heather Curry at 703-390-9822 or &lt;A href=&quot;mailto:hcurry@acr.org&quot;&gt;hcurry@acr.org&lt;/A&gt;.&lt;/P&gt;&lt;A onclick=&quot;window.opener.focus();return false;&quot; href=&quot;http://www.eurekalert.org/pubnews.php&quot;&gt;&lt;IMG border=0 alt=&quot;[ Back to EurekAlert! ]&quot; align=right src=&quot;/back2e.gif&quot; width=140 height=36&gt;&lt;/A&gt; [ | &lt;A onclick=&quot;visit(&#39;http://www.eurekalert.org/emailrelease.php?file=acor-moc102910.php&#39;)&quot; href=&quot;about:blank#&quot; target=_self&gt;E-mail&lt;/A&gt; | &lt;A onmouseover=&quot;return addthis_open(this, &#39;&#39;, &#39;[URL]&#39;, &#39;[TITLE]&#39;)&quot; onmouseout=addthis_close() onclick=&quot;return addthis_sendto()&quot; href=&quot;http://www.addthis.com/bookmark.php?v=20&quot;&gt;&lt;IMG border=0 alt=Share src=&quot;/shareicon.gif&quot; width=11 height=11&gt; Share&lt;/A&gt; ] &lt;br /&gt;&lt;p&gt;&lt;a href=&quot;http://www.medworm.com/index.php?rid=4122127&amp;cid=c_2_46_f&amp;fid=31011&amp;url=http%3A%2F%2Fwww.eurekalert.org%2Fpub_releases%2F2010-11%2Facor-moc102910.php&quot; target=&quot;_blank&quot; rel=&quot;nofollow&quot;&gt;View the original article here&lt;/a&gt;&lt;/p&gt;</content><link rel='replies' type='application/atom+xml' href='http://nmdbreastcancerawareness.blogspot.com/feeds/8464301980632062387/comments/default' title='Post Comments'/><link rel='replies' type='text/html' href='http://nmdbreastcancerawareness.blogspot.com/2010/11/maj-of-comm-facilities-performing.html#comment-form' title='0 Comments'/><link rel='edit' type='application/atom+xml' href='http://www.blogger.com/feeds/763914643556275777/posts/default/8464301980632062387'/><link rel='self' type='application/atom+xml' href='http://www.blogger.com/feeds/763914643556275777/posts/default/8464301980632062387'/><link rel='alternate' type='text/html' href='http://nmdbreastcancerawareness.blogspot.com/2010/11/maj-of-comm-facilities-performing.html' title='Maj. of comm. facilities performing breast MRI exams meet ACRIN and EUSOBI technical requirements'/><author><name>Anonymous</name><uri>http://www.blogger.com/profile/14799558047407972898</uri><email>noreply@blogger.com</email><gd:image rel='http://schemas.google.com/g/2005#thumbnail' width='16' height='16' src='https://img1.blogblog.com/img/b16-rounded.gif'/></author><thr:total>0</thr:total></entry><entry><id>tag:blogger.com,1999:blog-763914643556275777.post-820401933967482014</id><published>2010-11-14T13:47:00.000-08:00</published><updated>2010-11-14T13:47:00.212-08:00</updated><category scheme="http://www.blogger.com/atom/ns#" term="8p1112"/><category scheme="http://www.blogger.com/atom/ns#" term="Amplified"/><category scheme="http://www.blogger.com/atom/ns#" term="Breast"/><category scheme="http://www.blogger.com/atom/ns#" term="Cancer"/><category scheme="http://www.blogger.com/atom/ns#" term="Genes"/><category scheme="http://www.blogger.com/atom/ns#" term="human"/><category scheme="http://www.blogger.com/atom/ns#" term="properties"/><category scheme="http://www.blogger.com/atom/ns#" term="Transforming"/><title type='text'>Transforming Properties of 8p11-12 Amplified Genes in Human Breast Cancer</title><content type='html'>    Transforming Properties of 8p11-12 Amplified Genes in Human Breast Cancer — Cancer Res                                           &lt;body&gt;   &lt;img id=&quot;main-logo&quot; title=&quot;Journal Name&quot; src=&quot;C:\Program Files\ABS\Auto Blog Samurai\data\Breast Cancer Awareness\Medworm\journal_logo.gif&quot; alt=&quot;Journal Logo&quot; /&gt;   &lt;a href=&quot;#content-block&quot;&gt;Skip to main page content&lt;/a&gt;  &lt;/p&gt;   &lt;a href=&quot;/&quot; title=&quot;Home&quot;&gt;Home&lt;/a&gt; &lt;a href=&quot;/content/early/recent&quot; title=&quot;OnlineFirst&quot;&gt;OnlineFirst&lt;/a&gt; &lt;a href=&quot;/content/current&quot; title=&quot;Current Issue&quot;&gt;Current Issue&lt;/a&gt; &lt;a href=&quot;/content/by/year&quot; title=&quot;Past Issues&quot;&gt;Past Issues&lt;/a&gt; &lt;a href=&quot;/site/subscriptions/&quot; title=&quot;Subscriptions&quot;&gt;Subscriptions&lt;/a&gt; &lt;a href=&quot;/site/subscriptions/etoc.xhtml&quot; title=&quot;Alerts&quot;&gt;Alerts&lt;/a&gt; &lt;a href=&quot;/feedback&quot; title=&quot;Feedback&quot;&gt;Feedback&lt;/a&gt; &lt;a href=&quot;http://www.aacrjournals.org/&quot; title=&quot;AACR Publications&quot;&gt;AACR Publications&lt;/a&gt; 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/&gt;&lt;/a&gt;       Transforming Properties of 8p11-12 Amplified Genes in Human Breast Cancer   &lt;a class=&quot;name-search&quot; href=&quot;/search?author1=Zeng-Quan+Yang&amp;sortspec=date&amp;submit=Submit&quot;&gt;Zeng-Quan Yang&lt;/a&gt;&lt;a id=&quot;xref-aff-1-1&quot; class=&quot;xref-aff&quot; href=&quot;#aff-1&quot;&gt;1&lt;/a&gt;,   &lt;a class=&quot;name-search&quot; href=&quot;/search?author1=Gang+Liu&amp;sortspec=date&amp;submit=Submit&quot;&gt;Gang Liu&lt;/a&gt;&lt;a id=&quot;xref-aff-1-2&quot; class=&quot;xref-aff&quot; href=&quot;#aff-1&quot;&gt;1&lt;/a&gt;,   &lt;a class=&quot;name-search&quot; href=&quot;/search?author1=Aliccia+Bollig-Fischer&amp;sortspec=date&amp;submit=Submit&quot;&gt;Aliccia Bollig-Fischer&lt;/a&gt;&lt;a id=&quot;xref-aff-1-3&quot; class=&quot;xref-aff&quot; href=&quot;#aff-1&quot;&gt;1&lt;/a&gt;,   &lt;a class=&quot;name-search&quot; href=&quot;/search?author1=Craig+N.+Giroux&amp;sortspec=date&amp;submit=Submit&quot;&gt;Craig N. Giroux&lt;/a&gt;&lt;a id=&quot;xref-aff-1-4&quot; class=&quot;xref-aff&quot; href=&quot;#aff-1&quot;&gt;2&lt;/a&gt;, and   &lt;a class=&quot;name-search&quot; href=&quot;/search?author1=Stephen+P.+Ethier&amp;sortspec=date&amp;submit=Submit&quot;&gt;Stephen P. Ethier&lt;/a&gt;&lt;a id=&quot;xref-aff-1-5&quot; class=&quot;xref-aff&quot; href=&quot;#aff-1&quot;&gt;1&lt;/a&gt;   &lt;a id=&quot;aff-1&quot; name=&quot;aff-1&quot;&gt;&lt;/a&gt;&lt;address&gt;&lt;strong&gt;Authors&#39; Affiliations:&lt;/strong&gt;1Breast Cancer Program and 2Systems and Computational Biology, Karmanos Cancer Institute, Wayne State University, Detroit, Michigan     &lt;strong&gt;Corresponding Author:&lt;/strong&gt;&lt;br /&gt; Zeng-Quan Yang, Karmanos Cancer Institute, 4100 John R HWCRC 815, Detroit, MI 48201. Phone: 313-576-8339; Fax: 313-576-8029; E-mail: yangz{at}karmanos.org.     Z.-Q. Yang and G. Liu contributed equally to this work.&lt;/p&gt;     Abstract Amplification of the 8p11-12 region has been found in about 15% of human breast cancers and is associated with poor prognosis. Earlier, we used genomic analysis of copy number and gene expression to perform a detailed analysis of the 8p11-12 amplicon to identify candidate oncogenes in breast cancer. We identified 21 candidate genes and provided evidence that three genes, namely, LSM-1, TC-1&lt;/em&gt;, and BAG4&lt;/em&gt;, have transforming properties when overexpressed. In the present study, we systematically investigated the transforming properties of 13 newly identified 8p11-12 candidate oncogenes in vitro. WHSC1L1, DDHD2&lt;/em&gt;, and ERLIN2&lt;/em&gt; were most potently transforming oncogenes based on the number of altered phenotypes expressed by the cells. WHSC1L1 contains a PWWP-domain that is a methyl-lysine recognition motif involved in histone code modification and epigenetic regulation of gene expression. Knockdown of WHSC1L1&lt;/em&gt; in 8p11-12–amplified breast cancer cells resulted in profound loss of growth and survival of these cells. Further, we identified several WHSC1L1 target genes, one of which is iroquois homeobox 3 gene (IRX3&lt;/em&gt;), a member of the Iroquois homeobox transcription factor family. Cancer Res; 70(21); 8487–97. ©2010 AACR. &lt;/p&gt;   Footnotes   &lt;strong&gt;Note:&lt;/strong&gt; Supplementary data for this article are available at Cancer Research Online (&lt;a href=&quot;http://cancerres.aacrjournals.org/&quot;&gt;http://cancerres.aacrjournals.org/&lt;/a&gt;). &lt;/p&gt;     Received March 22, 2010.  Revision received August 27, 2010.  Accepted August 27, 2010.    ©2010 American Association for Cancer Research.      &lt;a href=&quot;/external-ref?tag_url=http://cancerres.aacrjournals.org/cgi/content/long/70/21/8487&amp;title=Transforming%20Properties%20of%208p11-12%20Amplified%20Genes%20in%20Human%20Breast%20Cancer+--+Yang%20et%20al.%2070%20%2821%29%3A%208487+--+&amp;doi=10.1158/0008-5472.CAN-10-1013&amp;link_type=CITEULIKE&quot;&gt;&lt;img src=&quot;C:\Program Files\ABS\Auto Blog Samurai\data\Breast Cancer Awareness\Medworm\citeulike.gif&quot; alt=&quot;Add to CiteULike&quot; title=&quot;CiteULike&quot; /&gt;CiteULike&lt;/a&gt; &lt;a href=&quot;/external-ref?tag_url=http://cancerres.aacrjournals.org/cgi/content/long/70/21/8487&amp;title=Transforming%20Properties%20of%208p11-12%20Amplified%20Genes%20in%20Human%20Breast%20Cancer+--+Yang%20et%20al.%2070%20%2821%29%3A%208487+--+&amp;doi=10.1158/0008-5472.CAN-10-1013&amp;link_type=COMPLORE&quot;&gt;&lt;img src=&quot;C:\Program Files\ABS\Auto Blog Samurai\data\Breast Cancer Awareness\Medworm\complore.gif&quot; 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target=&quot;_blank&quot; rel=&quot;nofollow&quot;&gt;View the original article here&lt;/a&gt;&lt;/p&gt;</content><link rel='replies' type='application/atom+xml' href='http://nmdbreastcancerawareness.blogspot.com/feeds/820401933967482014/comments/default' title='Post Comments'/><link rel='replies' type='text/html' href='http://nmdbreastcancerawareness.blogspot.com/2010/11/transforming-properties-of-8p11-12.html#comment-form' title='0 Comments'/><link rel='edit' type='application/atom+xml' href='http://www.blogger.com/feeds/763914643556275777/posts/default/820401933967482014'/><link rel='self' type='application/atom+xml' href='http://www.blogger.com/feeds/763914643556275777/posts/default/820401933967482014'/><link rel='alternate' type='text/html' href='http://nmdbreastcancerawareness.blogspot.com/2010/11/transforming-properties-of-8p11-12.html' title='Transforming Properties of 8p11-12 Amplified Genes in Human Breast Cancer'/><author><name>Anonymous</name><uri>http://www.blogger.com/profile/14799558047407972898</uri><email>noreply@blogger.com</email><gd:image rel='http://schemas.google.com/g/2005#thumbnail' width='16' height='16' src='https://img1.blogblog.com/img/b16-rounded.gif'/></author><thr:total>0</thr:total></entry><entry><id>tag:blogger.com,1999:blog-763914643556275777.post-4332855474651176553</id><published>2010-11-14T07:41:00.000-08:00</published><updated>2010-11-14T07:41:00.232-08:00</updated><category scheme="http://www.blogger.com/atom/ns#" term="Breast"/><category scheme="http://www.blogger.com/atom/ns#" term="Cancer"/><category scheme="http://www.blogger.com/atom/ns#" term="Portable"/><category scheme="http://www.blogger.com/atom/ns#" term="Scanner"/><title type='text'>New Portable Scanner for Breast Cancer</title><content type='html'> &lt;BODY readability=&quot;0&quot;&gt;In order to use Medscape, your browser must be set to accept cookies delivered by the Medscape site. To find out how to adjust your browser settings to accept cookies, please &lt;A onclick=&quot;resizeWin(&#39;Figure&#39;,400,520)&quot; href=&quot;about:www.medscape.com/pjsp/public/help/registration/allowcookies.html&quot; target=Figure&gt;click here&lt;/A&gt;. &lt;P&gt;Medscape uses cookies to customize the site based on the information we collect at registration. The cookies contain no personally identifiable information and have no effect once you leave the Medscape site. You can read more about our use of cookies in our &lt;A onclick=&quot;resizeWin(&#39;Figure&#39;,400,520)&quot; href=&quot;about:www.medscape.com/pjsp/public/privacy.html&quot; target=Figure&gt;privacy policy&lt;/A&gt;.&lt;/P&gt;&lt;br /&gt;&lt;p&gt;&lt;a href=&quot;http://www.medworm.com/index.php?rid=4110133&amp;cid=c_2_26_f&amp;fid=36062&amp;url=http%3A%2F%2Fwww.medscape.com%2Fviewarticle%2F731494%3Fsrc%3Drss&quot; target=&quot;_blank&quot; rel=&quot;nofollow&quot;&gt;View the original article here&lt;/a&gt;&lt;/p&gt;</content><link rel='replies' type='application/atom+xml' href='http://nmdbreastcancerawareness.blogspot.com/feeds/4332855474651176553/comments/default' title='Post Comments'/><link rel='replies' type='text/html' href='http://nmdbreastcancerawareness.blogspot.com/2010/11/new-portable-scanner-for-breast-cancer.html#comment-form' title='0 Comments'/><link rel='edit' type='application/atom+xml' href='http://www.blogger.com/feeds/763914643556275777/posts/default/4332855474651176553'/><link rel='self' type='application/atom+xml' href='http://www.blogger.com/feeds/763914643556275777/posts/default/4332855474651176553'/><link rel='alternate' type='text/html' href='http://nmdbreastcancerawareness.blogspot.com/2010/11/new-portable-scanner-for-breast-cancer.html' title='New Portable Scanner for Breast Cancer'/><author><name>Anonymous</name><uri>http://www.blogger.com/profile/14799558047407972898</uri><email>noreply@blogger.com</email><gd:image rel='http://schemas.google.com/g/2005#thumbnail' width='16' height='16' src='https://img1.blogblog.com/img/b16-rounded.gif'/></author><thr:total>0</thr:total></entry><entry><id>tag:blogger.com,1999:blog-763914643556275777.post-5317556053266116523</id><published>2010-11-14T01:10:00.000-08:00</published><updated>2010-11-14T01:10:00.320-08:00</updated><category scheme="http://www.blogger.com/atom/ns#" term="Breast"/><category scheme="http://www.blogger.com/atom/ns#" term="Cancer"/><category scheme="http://www.blogger.com/atom/ns#" term="Controlling"/><category scheme="http://www.blogger.com/atom/ns#" term="Elderly"/><category scheme="http://www.blogger.com/atom/ns#" term="Finds"/><category scheme="http://www.blogger.com/atom/ns#" term="Study"/><category scheme="http://www.blogger.com/atom/ns#" term="Surgery"/><category scheme="http://www.blogger.com/atom/ns#" term="Women"/><title type='text'>Surgery Best for Controlling Breast Cancer in Elderly Women, Study Finds</title><content type='html'> &lt;BODY readability=&quot;0&quot;&gt;The file you requested cannot be not found in the system.&lt;/P&gt;&lt;P&gt;&lt;A title=&quot;Return to Archives&quot; href=&quot;about:index.cfm&quot;&gt;Return to Archives&lt;/A&gt;&lt;/P&gt;Sorry, I could not read the content fromt this page.&lt;br /&gt;&lt;p&gt;&lt;a href=&quot;http://www.medworm.com/index.php?rid=4112153&amp;cid=c_2_26_f&amp;fid=23286&amp;url=http%3A%2F%2Fwww.cfah.org%2Fhbns%2Farchives%2FgetDocument.cfm%3FdocumentID%3D1213&quot; target=&quot;_blank&quot; rel=&quot;nofollow&quot;&gt;View the original article here&lt;/a&gt;&lt;/p&gt;</content><link rel='replies' type='application/atom+xml' href='http://nmdbreastcancerawareness.blogspot.com/feeds/5317556053266116523/comments/default' title='Post Comments'/><link rel='replies' type='text/html' href='http://nmdbreastcancerawareness.blogspot.com/2010/11/surgery-best-for-controlling-breast.html#comment-form' title='0 Comments'/><link rel='edit' type='application/atom+xml' href='http://www.blogger.com/feeds/763914643556275777/posts/default/5317556053266116523'/><link rel='self' type='application/atom+xml' href='http://www.blogger.com/feeds/763914643556275777/posts/default/5317556053266116523'/><link rel='alternate' type='text/html' href='http://nmdbreastcancerawareness.blogspot.com/2010/11/surgery-best-for-controlling-breast.html' title='Surgery Best for Controlling Breast Cancer in Elderly Women, Study Finds'/><author><name>Anonymous</name><uri>http://www.blogger.com/profile/14799558047407972898</uri><email>noreply@blogger.com</email><gd:image rel='http://schemas.google.com/g/2005#thumbnail' width='16' height='16' src='https://img1.blogblog.com/img/b16-rounded.gif'/></author><thr:total>0</thr:total></entry><entry><id>tag:blogger.com,1999:blog-763914643556275777.post-1105448012093001513</id><published>2010-11-13T18:18:00.000-08:00</published><updated>2010-11-13T18:18:00.356-08:00</updated><category scheme="http://www.blogger.com/atom/ns#" term="Breast"/><category scheme="http://www.blogger.com/atom/ns#" term="Cancer"/><category scheme="http://www.blogger.com/atom/ns#" term="cohort"/><category scheme="http://www.blogger.com/atom/ns#" term="Incidence"/><category scheme="http://www.blogger.com/atom/ns#" term="metaanalysis"/><category scheme="http://www.blogger.com/atom/ns#" term="multiple"/><category scheme="http://www.blogger.com/atom/ns#" term="observational"/><category scheme="http://www.blogger.com/atom/ns#" term="review"/><category scheme="http://www.blogger.com/atom/ns#" term="sclerosis"/><category scheme="http://www.blogger.com/atom/ns#" term="studies"/><category scheme="http://www.blogger.com/atom/ns#" term="systematic"/><category scheme="http://www.blogger.com/atom/ns#" term="Women"/><title type='text'>[Incidence of breast cancer in women with multiple sclerosis: systematic review and meta-analysis of observational cohort studies.]</title><content type='html'> &lt;BODY readability=&quot;0&quot;&gt;Divisionde Farmacoepidemiologia y Farmacovigilancia, Agencia Espanola de Medicamentos y Productos Sanitarios, Campezo, Madrid, Spain. fcatala@aemps.es&lt;/P&gt;&lt;P&gt;AIM: To determine if women with multiple sclerosis (MS) reported an increased risk of breast cancer compared with the general female population.&lt;/P&gt;&lt;P&gt;PATIENTS AND METHODS: We conducted a systematic review and meta-analysis of observational cohort studies. We performed a search in PubMed/Medline of studies where standardized incidence ratios (SIRs) were provided. Overall estimates of the SIRs (meta-SIRs) were calculated using DerSimonian-Laird random effects models. Sources of heterogeneity were explored by means sub-groups analyses.&lt;/P&gt;&lt;P&gt;RESULTS: Five studies met the inclusion criteria. Women with MS were not associated with increased risk of overall (meta-SIR = 0.80; 95% confidence interval, 95% CI = 0.61-1.06) and breast cancers (meta-SIR = 1.02; 95% CI = 0.75-1.40). These differences did not turn out to be statistically significant. A high degree of heterogeneity between studies was found (I2 = 88.7% and I2 = 75.3%, respectively).&lt;/P&gt;&lt;P&gt;CONCLUSIONS: The data shown here suggest a similar risk of breast cancer in women with MS when compared to the general population. Further research is required to evaluate the role of specific risk factors at cancer sites such as effects of treatments used in the management of MS patients.&lt;/P&gt;&lt;br /&gt;&lt;p&gt;&lt;a href=&quot;http://www.medworm.com/index.php?rid=4114602&amp;cid=c_2_25_f&amp;fid=38199&amp;url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20979030%26dopt%3DAbstract&quot; target=&quot;_blank&quot; rel=&quot;nofollow&quot;&gt;View the original article here&lt;/a&gt;&lt;/p&gt;</content><link rel='replies' type='application/atom+xml' href='http://nmdbreastcancerawareness.blogspot.com/feeds/1105448012093001513/comments/default' title='Post Comments'/><link rel='replies' type='text/html' href='http://nmdbreastcancerawareness.blogspot.com/2010/11/incidence-of-breast-cancer-in-women.html#comment-form' title='0 Comments'/><link rel='edit' type='application/atom+xml' href='http://www.blogger.com/feeds/763914643556275777/posts/default/1105448012093001513'/><link rel='self' type='application/atom+xml' href='http://www.blogger.com/feeds/763914643556275777/posts/default/1105448012093001513'/><link rel='alternate' type='text/html' href='http://nmdbreastcancerawareness.blogspot.com/2010/11/incidence-of-breast-cancer-in-women.html' title='[Incidence of breast cancer in women with multiple sclerosis: systematic review and meta-analysis of observational cohort studies.]'/><author><name>Anonymous</name><uri>http://www.blogger.com/profile/14799558047407972898</uri><email>noreply@blogger.com</email><gd:image rel='http://schemas.google.com/g/2005#thumbnail' width='16' height='16' src='https://img1.blogblog.com/img/b16-rounded.gif'/></author><thr:total>0</thr:total></entry><entry><id>tag:blogger.com,1999:blog-763914643556275777.post-4097138469327256153</id><published>2010-11-13T09:17:00.000-08:00</published><updated>2010-11-13T09:17:00.770-08:00</updated><category scheme="http://www.blogger.com/atom/ns#" term="Breast"/><category scheme="http://www.blogger.com/atom/ns#" term="Cancer"/><category scheme="http://www.blogger.com/atom/ns#" term="Enhances"/><category scheme="http://www.blogger.com/atom/ns#" term="Nanoparticle"/><category scheme="http://www.blogger.com/atom/ns#" term="Penetration"/><category scheme="http://www.blogger.com/atom/ns#" term="Pulsed"/><category scheme="http://www.blogger.com/atom/ns#" term="Spheroids"/><category scheme="http://www.blogger.com/atom/ns#" term="Ultrasound"/><title type='text'>Pulsed Ultrasound Enhances Nanoparticle Penetration into Breast Cancer Spheroids</title><content type='html'> &lt;BODY readability=&quot;0&quot;&gt;&lt;IMG alt=&quot;Abstract Image&quot; src=&quot;/mp-2010-00280b0009.gif&quot;&gt;Effective treatment of solid tumors requires homogeneous distribution of anticancer drugs within the entire tumor volume to deliver lethal concentrations to resistant cancer cells and tumor-initiating cancer stem cells. However, penetration of small molecular weight chemotherapeutic agents and drug-loaded polymeric and lipid particles into the hypoxic and necrotic regions of solid tumors remains a significant challenge. This article reports the results of pulsed ultrasound enhanced penetration of nanosized fluorescent particles into MCF-7 breast cancer spheroids (300-350 µm diameter) as a function of particle size and charge. With pulsed ultrasound application in the presence of microbubbles, small (20 nm) particles achieve 6-20-fold higher penetration and concentration in the spheroid’s core compared to those not exposed to ultrasound. Increase in particle size to 40 and 100 nm results in their effective penetration into the spheroid’s core to 9- and 3-fold, respectively. In addition, anionic carboxylate particles achieved higher penetration (2.3-, 3.7-, and 4.7-fold) into the core of MCF-7 breast cancer spheroids compared to neutral (2.2-, 1.9-, and 2.4-fold) and cationic particles (1.5-, 1.4-, and 1.9-fold) upon US exposure for 30, 60, and 90 s under the same experimental conditions. These results demonstrate the feasibility of utilizing pulsed ultrasound to increase the penetration of nanosized particles into MCF-7 spheroids mimicking tumor tissue. The effects of particle properties on the penetration enhancement were also illustrated.&lt;/P&gt;Ultrasound; microbubbles; nanoparticles; spheroids; drug delivery; fluorescence microscopy&lt;br /&gt;&lt;p&gt;&lt;a href=&quot;http://www.medworm.com/index.php?rid=4120542&amp;cid=c_2_13_f&amp;fid=32527&amp;url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2Facs%2Fmpohbp%2F%7E3%2FYsg9gME2Y_I%2Fmp100280b&quot; target=&quot;_blank&quot; rel=&quot;nofollow&quot;&gt;View the original article here&lt;/a&gt;&lt;/p&gt;</content><link rel='replies' type='application/atom+xml' href='http://nmdbreastcancerawareness.blogspot.com/feeds/4097138469327256153/comments/default' title='Post Comments'/><link rel='replies' type='text/html' href='http://nmdbreastcancerawareness.blogspot.com/2010/11/pulsed-ultrasound-enhances-nanoparticle.html#comment-form' title='0 Comments'/><link rel='edit' type='application/atom+xml' href='http://www.blogger.com/feeds/763914643556275777/posts/default/4097138469327256153'/><link rel='self' type='application/atom+xml' href='http://www.blogger.com/feeds/763914643556275777/posts/default/4097138469327256153'/><link rel='alternate' type='text/html' href='http://nmdbreastcancerawareness.blogspot.com/2010/11/pulsed-ultrasound-enhances-nanoparticle.html' title='Pulsed Ultrasound Enhances Nanoparticle Penetration into Breast Cancer Spheroids'/><author><name>Anonymous</name><uri>http://www.blogger.com/profile/14799558047407972898</uri><email>noreply@blogger.com</email><gd:image rel='http://schemas.google.com/g/2005#thumbnail' width='16' height='16' src='https://img1.blogblog.com/img/b16-rounded.gif'/></author><thr:total>0</thr:total></entry><entry><id>tag:blogger.com,1999:blog-763914643556275777.post-2805174486926830884</id><published>2010-11-13T02:16:00.000-08:00</published><updated>2010-11-13T02:16:00.486-08:00</updated><category scheme="http://www.blogger.com/atom/ns#" term="Breast"/><category scheme="http://www.blogger.com/atom/ns#" term="Cancer"/><category scheme="http://www.blogger.com/atom/ns#" term="CyberKnife"/><category scheme="http://www.blogger.com/atom/ns#" term="EarlyStage"/><category scheme="http://www.blogger.com/atom/ns#" term="Radiosurgery"/><title type='text'>CyberKnife Radiosurgery for Early-Stage Breast Cancer</title><content type='html'> &lt;BODY readability=&quot;0&quot;&gt;&lt;P&gt;SUNNYVALE, Calif., Oct. 31 -- (Healthcare Sales &amp; Marketing Network) -- Accuray Incorporated, (Nasdaq: ARAY), a global leader in the field of radiosurgery, announced today studies underway at two leading academic institutions using CyberKnife radiosurgery in breast cancer treatment. These two studies, from the University of Texas Southwestern and Fox Chase Cancer Center, will be presented at the 52nd Annual Meeting of the American Society for Radiation Oncology (ASTRO) in San Diego from October 31 to November 4.&lt;/P&gt;According to the American Cancer Society, breast cancer is the most frequently diagnosed cancer among women and the second leading cause of cancer death. Typically, women with early stage, localized breast cancer are treated with a lumpectomy, also known as breast conserving surgery, followed by radiation to ensure any remaining microscopic cancer cells are treated. It has been shown that women receiving radiation following surgery have more than a 15 percent reduction in recurrence rates as compared to women who did not receive radiation after their tumors were surgically removed(1). &lt;P&gt;Initially clinicians delivered radiation to the whole breast following surgery, but over the last decade a more limited radiation approach has gained interest among clinicians and patients. This approach, called partial breast irradiation, can be as effective as whole breast irradiation and is less likely to damage to the heart, lungs, and skin, leading to improved cosmetic outcomes and reduced toxicities.(2)&lt;/P&gt;&lt;P&gt;Partial breast irradiation can be delivered in a number of ways, including invasive options, such as MammoSite, which involves surgical implantation of a catheter in the breast to deliver interstitial brachytherapy, or non-invasive radiation therapy options such as 3D conformal or intensity modulated radiation therapy (IMRT).&lt;/P&gt;&lt;P&gt;Each technique has its advantages and drawbacks: For example, invasive brachytherapy can cause infection, hematoma or abscess(3-4). While non-invasive radiation therapy approaches minimize such risks, studies have demonstrated that the larger margins required to compensate for treatment inaccuracies, such as those caused by the movement of the breast with respiration, result in a higher risk for overdosing the skin and nearby critical structures such as the heart and lungs(5-7). One recent study investigating IMRT for partial breast irradiation found 7 out of 32 evaluated patients developed unacceptable cosmesis, leading to premature closure of the study(5).&lt;/P&gt;&lt;P&gt;Because of the non-invasive delivery and high precision that the CyberKnife System offers in treating tumors throughout the body, clinicians see a role for it in breast cancer treatment. The CyberKnife System has the unique ability to not only track tumor movement during respiration, but to also lock onto the tumor as it moves delivering radiation directly to the tumor and avoiding damage to surrounding critical structures. The CyberKnife System&#39;s extreme precision enables clinicians to reduce the treatment margins that are often added with conventional IMRT Systems. For this reason, clinicians believe partial breast irradiation using the CyberKnife System holds the potential to improve toxicity and associated side effects for patients.&lt;/P&gt;&lt;P&gt;&quot;We think that the real-time tracking and high conformality made possible with the CyberKnife System could result in reduced toxicity by reducing the dose to the surrounding breast tissue, skin, chest wall, lung or heart,&quot; said Charlie Ma, Ph.D., Professor and Vice-Chairman, Department of Radiation Oncology, Fox Chase Cancer Center.&lt;/P&gt;&lt;P&gt;University of Texas Southwestern recently launched a multi-center early stage breast cancer protocol, which is currently accruing patients. UTSW was one of the first five CyberKnife sites in the world and has remained on the forefront of clinical research.&lt;/P&gt;&lt;P&gt;Physicians at UTSW intend to demonstrate equivalent local control rates or to improve those seen in current treatment for early-stage disease while attempting to increase convenience, limit invasiveness, decrease toxicity and improve cosmesis compared to other methods of radiation treatment. The treatment regimen using the CyberKnife System would be five days compared to 25-30 days typically associated with conventional radiation therapy.&lt;/P&gt;&lt;P&gt;&quot;In particular, we believe a very abbreviated, non-invasive, outpatient treatment would be considered a favorable option to underserved populations of women living in more remote areas for whom longer courses of treatment pose a barrier,&quot; said Robert Timmerman, M.D., professor of Radiation Oncology at UTSW and lead author of the ongoing study.&lt;/P&gt;&lt;P&gt;(1). Fisher B, Anderson S, Bryant J, Margolese R, Deutsch M, Fisher E, Jeong J-H, Wolmark N. Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer. New England Journal of Medicine 2002; 347:1233-1241.&lt;/P&gt;&lt;P&gt;(2). Wadasadawala T, Sarin R, Budrukker A et al. Accelerated partial-breast irradiation vs conventional whole-breast radiotherapy in early breast cancer: A case-control study of disease control, cosmesis, and complications. Journal of Cancer Research &amp; Therapy 2009: 5:2 93-101.&lt;/P&gt;&lt;P&gt;(3). Watkins JM, Harper JL, Dragun AE, Ashenafi MS, Sinha D, Li J, Cole DJ, Jenrette JM 3rd. Incidence and prognostic factors for seroma development after MammoSite breast brachytherapy. Brachytherapy. 2008;7:305-9.&lt;/P&gt;&lt;P&gt;(4). Evans SB, Kaufman SA, Price LL, Cardarelli G, Dipetrillo TA, Wazer DE. Persistent seroma after intraoperative placement of MammoSite for accelerated partial breast irradiation: incidence, pathologic anatomy, and contributing factors. Int J Radiat Oncol Biol Phys. 2006;65:333-9.&lt;/P&gt;&lt;P&gt;(5). Jagsi R, Ben-David MA, Moran JM, Marsh RB, Griffith KA, Hayman JA, Pierce LJ. Unacceptable cosmesis in a protocol investigating intensity-modulated radiotherapy with active breathing control for accelerated partial-breast irradiation. Int J Radiat Oncol Biol Phys. 2010;76:71-8.&lt;/P&gt;&lt;P&gt;(6). Vicini FA, Chen P, Wallace M, Mitchell C, Hasan Y, Grills I, Kestin L, Schell S, Goldstein NS, Kunzman J, Gilbert S, Martinez A. Interim cosmetic results and toxicity using 3D conformal external beam radiotherapy to deliver accelerated partial breast irradiation in patients with early-stage breast cancer treated with breast-conserving therapy. Int J Radiat Oncol Biol Phys. 2007;69:1124-30.&lt;/P&gt;&lt;P&gt;(7). Livi L, Buonamici FB, Simontacchi G, Scotti V, Fambrini M, Compagnucci A, Paiar F, Scoccianti S, Pallotta S, Detti B, Agresti B, Talamonti C, Mangoni M, Bianchi S, Cataliotti L, Marrazzo L, Bucciolini M, Biti G. Accelerated partial breast irradiation with IMRT: new technical approach and interim analysis of acute toxicity in a phase III randomized clinical trial. Int J Radiat Oncol Biol Phys. 2010;77:509-15.&lt;/P&gt;&lt;P&gt;About the CyberKnife? Robotic Radiosurgery System&lt;/P&gt;&lt;P&gt;The CyberKnife Robotic Radiosurgery System is the world&#39;s only robotic radiosurgery system designed to treat tumors anywhere in the body non-invasively. Using continual image guidance technology and computer controlled robotic mobility, the CyberKnife System automatically tracks, detects and corrects for tumor and patient movement in real-time throughout the treatment. This enables the CyberKnife System to deliver high-dose radiation with pinpoint precision, which minimizes damage to surrounding healthy tissue and eliminates the need for invasive head or body stabilization frames.&lt;/P&gt;&lt;P&gt;About Accuray&lt;/P&gt;&lt;P&gt;Accuray Incorporated (Nasdaq:ARAY ), based in Sunnyvale, Calif., is a global leader in the field of radiosurgery dedicated to providing an improved quality of life and a non-surgical treatment option for those diagnosed with cancer. Accuray develops and markets the CyberKnife Robotic Radiosurgery System, which extends the benefits of radiosurgery to include extracranial tumors, including those in the spine, lung, prostate, liver and pancreas. To date, the CyberKnife System has been used to treat more 100,000 patients worldwide and more than 206 systems have been installed in leading hospitals in the Americas, Europe and Asia. For more information, please visit www.accuray.com. &lt;/P&gt;&lt;P&gt;Safe Harbor Statement&lt;/P&gt;&lt;P&gt;The foregoing may contain certain forward-looking statements that involve risks and uncertainties, including uncertainties associated with the medical device industry. Except for the historical information contained herein, the matters set forth in this press release, including statements relating to clinical evidence and clinical results are forward-looking statements within the meaning of the &quot;safe harbor&quot; provisions of the Private Securities Litigation Reform Act of 1995. Forward-looking statements speak only as of the date the statements are made and are based on information available at the time those statements are made and/or management&#39;s good faith belief as of that time with respect to future events. You should not put undue reliance on any forward-looking statements. Important factors that could cause actual performance and results to differ materially from the forward-looking statements we make include: clinical applications, clinical outcomes, potential results of clinical studies, competing products, the combination of our products with complementary technology; and other risks detailed from time to time under the heading &quot;Risk Factors&quot; in our report on Form 10-K for the 2010 fiscal year which has been filed with the Securities and Exchange Commission, filed on August 31, 2010. The Company&#39;s actual results of operations may differ significantly from those contemplated by such forward-looking statements as a result of these and other factors. We assume no obligation to update forward-looking statements to reflect actual performance or results, changes in assumptions or changes in other factors affecting forward-looking information, except to the extent required by applicable securities laws.&lt;/P&gt;&lt;br /&gt;&lt;p&gt;&lt;a href=&quot;http://www.medworm.com/index.php?rid=4123134&amp;cid=c_2_34_f&amp;fid=35575&amp;url=http%3A%2F%2Fsalesandmarketingnetwork.com%2Fnews_release.php%3FID%3D2032013&quot; target=&quot;_blank&quot; rel=&quot;nofollow&quot;&gt;View the original article here&lt;/a&gt;&lt;/p&gt;</content><link rel='replies' type='application/atom+xml' href='http://nmdbreastcancerawareness.blogspot.com/feeds/2805174486926830884/comments/default' title='Post Comments'/><link rel='replies' type='text/html' href='http://nmdbreastcancerawareness.blogspot.com/2010/11/cyberknife-radiosurgery-for-early-stage_13.html#comment-form' title='1 Comments'/><link rel='edit' type='application/atom+xml' href='http://www.blogger.com/feeds/763914643556275777/posts/default/2805174486926830884'/><link rel='self' type='application/atom+xml' href='http://www.blogger.com/feeds/763914643556275777/posts/default/2805174486926830884'/><link rel='alternate' type='text/html' href='http://nmdbreastcancerawareness.blogspot.com/2010/11/cyberknife-radiosurgery-for-early-stage_13.html' title='CyberKnife Radiosurgery for Early-Stage Breast Cancer'/><author><name>Anonymous</name><uri>http://www.blogger.com/profile/14799558047407972898</uri><email>noreply@blogger.com</email><gd:image rel='http://schemas.google.com/g/2005#thumbnail' width='16' height='16' src='https://img1.blogblog.com/img/b16-rounded.gif'/></author><thr:total>1</thr:total></entry><entry><id>tag:blogger.com,1999:blog-763914643556275777.post-2158096825215036524</id><published>2010-11-12T20:09:00.000-08:00</published><updated>2010-11-12T20:09:00.226-08:00</updated><category scheme="http://www.blogger.com/atom/ns#" term="Chemotherapyassociated"/><category scheme="http://www.blogger.com/atom/ns#" term="lymphangioleiomyomatosis"/><category scheme="http://www.blogger.com/atom/ns#" term="pneumothoraces"/><category scheme="http://www.blogger.com/atom/ns#" term="recurrent"/><title type='text'>Chemotherapy-associated recurrent pneumothoraces in lymphangioleiomyomatosis.</title><content type='html'> &lt;BODY readability=&quot;0&quot;&gt;Department of Medicine and Therapeutics, University College Dublin, St Vincent&#39;s University Hospital, Elm Park, Dublin 4, Ireland. emermariekelly@hotmail.com.&lt;/P&gt;&lt;P&gt;Lymphangioleiomyomatosis is a rare cause of pneumothorax in women. We present the case of a 48-year-old woman with lymphangioleiomyomatosis, who had never had a pneumothorax prior to commencing chemotherapy for breast cancer. During chemotherapy she developed 3 pneumothoraces and 2 episodes of pneumomediastinum. We suggest that the pneumothoraces were caused by the chemotherapy. To our knowledge, this is the first reported case of chemotherapy triggering pneumothoraces in a woman with lymphangioleiomyomatosis.&lt;/P&gt;&lt;br /&gt;&lt;p&gt;&lt;a href=&quot;http://www.medworm.com/index.php?rid=4120166&amp;cid=c_2_40_f&amp;fid=28719&amp;url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20979677%26dopt%3DAbstract&quot; target=&quot;_blank&quot; rel=&quot;nofollow&quot;&gt;View the original article here&lt;/a&gt;&lt;/p&gt;</content><link rel='replies' type='application/atom+xml' href='http://nmdbreastcancerawareness.blogspot.com/feeds/2158096825215036524/comments/default' title='Post Comments'/><link rel='replies' type='text/html' href='http://nmdbreastcancerawareness.blogspot.com/2010/11/chemotherapy-associated-recurrent.html#comment-form' title='0 Comments'/><link rel='edit' type='application/atom+xml' href='http://www.blogger.com/feeds/763914643556275777/posts/default/2158096825215036524'/><link rel='self' type='application/atom+xml' href='http://www.blogger.com/feeds/763914643556275777/posts/default/2158096825215036524'/><link rel='alternate' type='text/html' href='http://nmdbreastcancerawareness.blogspot.com/2010/11/chemotherapy-associated-recurrent.html' title='Chemotherapy-associated recurrent pneumothoraces in lymphangioleiomyomatosis.'/><author><name>Anonymous</name><uri>http://www.blogger.com/profile/14799558047407972898</uri><email>noreply@blogger.com</email><gd:image rel='http://schemas.google.com/g/2005#thumbnail' width='16' height='16' src='https://img1.blogblog.com/img/b16-rounded.gif'/></author><thr:total>0</thr:total></entry><entry><id>tag:blogger.com,1999:blog-763914643556275777.post-3970187589399390480</id><published>2010-11-12T13:48:00.000-08:00</published><updated>2010-11-12T13:48:00.263-08:00</updated><category scheme="http://www.blogger.com/atom/ns#" term="Breast"/><category scheme="http://www.blogger.com/atom/ns#" term="Cancer"/><category scheme="http://www.blogger.com/atom/ns#" term="Doesnt"/><category scheme="http://www.blogger.com/atom/ns#" term="Finds"/><category scheme="http://www.blogger.com/atom/ns#" term="Green"/><category scheme="http://www.blogger.com/atom/ns#" term="Prevent"/><category scheme="http://www.blogger.com/atom/ns#" term="Study"/><title type='text'>Green Tea Doesn&amp;#39;t Prevent Breast Cancer, Study Finds</title><content type='html'> &lt;BODY readability=&quot;0&quot;&gt;In order to use Medscape, your browser must be set to accept cookies delivered by the Medscape site. To find out how to adjust your browser settings to accept cookies, please &lt;A onclick=&quot;resizeWin(&#39;Figure&#39;,400,520)&quot; href=&quot;about:www.medscape.com/pjsp/public/help/registration/allowcookies.html&quot; target=Figure&gt;click here&lt;/A&gt;. &lt;P&gt;Medscape uses cookies to customize the site based on the information we collect at registration. The cookies contain no personally identifiable information and have no effect once you leave the Medscape site. You can read more about our use of cookies in our &lt;A onclick=&quot;resizeWin(&#39;Figure&#39;,400,520)&quot; href=&quot;about:www.medscape.com/pjsp/public/privacy.html&quot; target=Figure&gt;privacy policy&lt;/A&gt;.&lt;/P&gt;&lt;br /&gt;&lt;p&gt;&lt;a href=&quot;http://www.medworm.com/index.php?rid=4112577&amp;cid=c_2_29_f&amp;fid=36057&amp;url=http%3A%2F%2Fwww.medscape.com%2Fviewarticle%2F731608%3Fsrc%3Drss&quot; target=&quot;_blank&quot; rel=&quot;nofollow&quot;&gt;View the original article here&lt;/a&gt;&lt;/p&gt;</content><link rel='replies' type='application/atom+xml' href='http://nmdbreastcancerawareness.blogspot.com/feeds/3970187589399390480/comments/default' title='Post Comments'/><link rel='replies' type='text/html' href='http://nmdbreastcancerawareness.blogspot.com/2010/11/green-tea-doesn-prevent-breast-cancer.html#comment-form' title='0 Comments'/><link rel='edit' type='application/atom+xml' href='http://www.blogger.com/feeds/763914643556275777/posts/default/3970187589399390480'/><link rel='self' type='application/atom+xml' href='http://www.blogger.com/feeds/763914643556275777/posts/default/3970187589399390480'/><link rel='alternate' type='text/html' href='http://nmdbreastcancerawareness.blogspot.com/2010/11/green-tea-doesn-prevent-breast-cancer.html' title='Green Tea Doesn&amp;#39;t Prevent Breast Cancer, Study Finds'/><author><name>Anonymous</name><uri>http://www.blogger.com/profile/14799558047407972898</uri><email>noreply@blogger.com</email><gd:image rel='http://schemas.google.com/g/2005#thumbnail' width='16' height='16' src='https://img1.blogblog.com/img/b16-rounded.gif'/></author><thr:total>0</thr:total></entry><entry><id>tag:blogger.com,1999:blog-763914643556275777.post-7711534273866769154</id><published>2010-11-12T05:57:00.000-08:00</published><updated>2010-11-12T05:57:00.361-08:00</updated><category scheme="http://www.blogger.com/atom/ns#" term="Magazines"/><title type='text'>Free Magazines</title><content type='html'> &lt;BODY readability=&quot;0&quot;&gt;&lt;P&gt;Popular magazines often feature articles on breast health – you can see those while you&#39;re waiting in line at the grocery store.  But if you&#39;re really interested in breast cancer and breast health issues, try some of these free or low-cost magazines.  I&#39;ve read over these publications, and can tell you that they do a good job explaining and communicating facts, news, and the personal side of breast cancer.&lt;/P&gt;&lt;P&gt;Cure&lt;/EM&gt; magazine covers more than one dozen kinds of cancer, with a section just for breast cancer.  This is a mostly upbeat but realistic magazine that serves up research, recent news, events, and personal stories about cancer diagnoses and treatments.  Written for patients and supporters, the text is easy to follow and graphics are appealing.  Cure magazine is affiliated with US Oncology, Inc., a network of oncology clinics and professionals.&lt;/P&gt;&lt;P&gt;Insight&lt;/EM&gt; is a newsletter-format magazine that skillfully blends personal stories with information on treatment decisions, personal challenges, and survival issues.  Easy to read and nicely presented, this LBBC publication includes news and resources you can use – such as conferences, meetings, and podcasts aimed at educating and supporting you.  Well written in a warm, confidant tone, Insight is well worth checking out. Insight is a publication of Living Beyond Breast Cancer.&lt;/P&gt;&lt;P&gt;Breast Cancer Wellness&lt;/EM&gt; is stuffed with down-to-earth advice written with a personal touch.  You&#39;ll find everything from recipes, diet advice, celebrity survivors, principles to thrive by, to advice for survivors and supporters.  Download a free sample copy from their website and see how friendly the magazine is – it&#39;s all for breast cancer survivors and thrivers.  They encourage reader participation and a sense of community – you&#39;ll be encouraged to send in your stories and opinions. Breast Cancer Wellness is a division of ONE Health Institute, an IRS qualified 501(c)3 charitable nonprofit foundation.&lt;/P&gt;&lt;P&gt;Coping®&lt;/EM&gt; With Cancer gives broad coverage of news, celebrity interviews, updates on treatments, lists of resources, and personal stories.  CWC covers 16 types of cancer, including breast cancer.  You&#39;ll also find information about financial and legal issues, treatment methods and side effects, personal relationships and wellness. Patients, caregivers and supporters can get help with coping during treatment as well as survival.  Coping®&lt;/EM&gt; With Cancer is owned by Media America, Inc.&lt;/P&gt;&lt;br /&gt;&lt;p&gt;&lt;a href=&quot;http://www.medworm.com/index.php?rid=4120427&amp;cid=c_2_6_f&amp;fid=38296&amp;url=http%3A%2F%2Fbreastcancer.about.com%2Fod%2FFree-Stuff-Cancer%2Ftp%2FFree-Magazines-And-Newsletters-About-Breast-Cancer.htm&quot; target=&quot;_blank&quot; rel=&quot;nofollow&quot;&gt;View the original article here&lt;/a&gt;&lt;/p&gt;</content><link rel='replies' type='application/atom+xml' href='http://nmdbreastcancerawareness.blogspot.com/feeds/7711534273866769154/comments/default' title='Post Comments'/><link rel='replies' type='text/html' href='http://nmdbreastcancerawareness.blogspot.com/2010/11/free-magazines.html#comment-form' title='0 Comments'/><link rel='edit' type='application/atom+xml' href='http://www.blogger.com/feeds/763914643556275777/posts/default/7711534273866769154'/><link rel='self' type='application/atom+xml' href='http://www.blogger.com/feeds/763914643556275777/posts/default/7711534273866769154'/><link rel='alternate' type='text/html' href='http://nmdbreastcancerawareness.blogspot.com/2010/11/free-magazines.html' title='Free Magazines'/><author><name>Anonymous</name><uri>http://www.blogger.com/profile/14799558047407972898</uri><email>noreply@blogger.com</email><gd:image rel='http://schemas.google.com/g/2005#thumbnail' width='16' height='16' src='https://img1.blogblog.com/img/b16-rounded.gif'/></author><thr:total>0</thr:total></entry><entry><id>tag:blogger.com,1999:blog-763914643556275777.post-5738581608428027959</id><published>2010-11-11T20:55:00.000-08:00</published><updated>2010-11-11T20:55:00.323-08:00</updated><category scheme="http://www.blogger.com/atom/ns#" term="cells"/><category scheme="http://www.blogger.com/atom/ns#" term="Embryonic"/><category scheme="http://www.blogger.com/atom/ns#" term="Kinase"/><category scheme="http://www.blogger.com/atom/ns#" term="Leucine"/><category scheme="http://www.blogger.com/atom/ns#" term="mammary"/><category scheme="http://www.blogger.com/atom/ns#" term="Maternal"/><category scheme="http://www.blogger.com/atom/ns#" term="Required"/><category scheme="http://www.blogger.com/atom/ns#" term="TumorInitiating"/><category scheme="http://www.blogger.com/atom/ns#" term="Upregulated"/><category scheme="http://www.blogger.com/atom/ns#" term="Zipper"/><title type='text'>Maternal Embryonic Leucine Zipper Kinase Is Upregulated and Required in Mammary Tumor-Initiating Cells In vivo</title><content type='html'>    Maternal Embryonic Leucine Zipper Kinase Is Upregulated and Required in Mammary Tumor-Initiating Cells In vivo — Cancer Res                                              &lt;body&gt; 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&lt;a href=&quot;http://www.aacr.org/&quot; title=&quot;AACR Home&quot;&gt;AACR Home&lt;/a&gt;        Search GO   &lt;a href=&quot;/search&quot;&gt;Advanced Search&lt;/a&gt;                      User Name  Password   Sign In                              &lt;a href=&quot;/cgi/adclick/?ad=26053&amp;adclick=true&amp;url=http%3A%2F%2Fwww.aacr.org%2Fpage22943.aspx&quot;&gt;&lt;img class=&quot;adborder0&quot; title=&quot;SU2C&quot; src=&quot;http://cancerres.aacrjournals.org/adsystem/graphics/624825180294919/canres/AACRInnov_430X90.jpg?ad=26053&amp;adview=true&quot; alt=&quot;SU2C&quot; /&gt;&lt;/a&gt; &lt;a href=&quot;/cgi/adclick/?ad=25621&amp;adclick=true&amp;url=http%3A%2F%2Fwww.aacr.org%2Fpage21407.aspx&quot;&gt;&lt;img class=&quot;adborder0&quot; title=&quot;PI3K&quot; src=&quot;http://cancerres.aacrjournals.org/adsystem/graphics/624825180294919/canres/TargetPI3k_430x90.jpg?ad=25621&amp;adview=true&quot; alt=&quot;PI3K&quot; /&gt;&lt;/a&gt;       Maternal Embryonic Leucine Zipper Kinase Is Upregulated and Required in Mammary Tumor-Initiating Cells In vivo&lt;/em&gt;   &lt;a class=&quot;name-search&quot; href=&quot;/search?author1=Lionel+W.+Hebbard&amp;sortspec=date&amp;submit=Submit&quot;&gt;Lionel W. Hebbard&lt;/a&gt;&lt;a id=&quot;xref-aff-1-1&quot; class=&quot;xref-aff&quot; href=&quot;#aff-1&quot;&gt;1&lt;/a&gt;,   &lt;a class=&quot;name-search&quot; href=&quot;/search?author1=Jochen+Maurer&amp;sortspec=date&amp;submit=Submit&quot;&gt;Jochen Maurer&lt;/a&gt;&lt;a id=&quot;xref-aff-1-2&quot; class=&quot;xref-aff&quot; href=&quot;#aff-1&quot;&gt;1&lt;/a&gt;,   &lt;a class=&quot;name-search&quot; href=&quot;/search?author1=Amber+Miller&amp;sortspec=date&amp;submit=Submit&quot;&gt;Amber Miller&lt;/a&gt;&lt;a id=&quot;xref-aff-1-3&quot; class=&quot;xref-aff&quot; href=&quot;#aff-1&quot;&gt;1&lt;/a&gt;,   &lt;a class=&quot;name-search&quot; href=&quot;/search?author1=Jacqueline+Lesperance&amp;sortspec=date&amp;submit=Submit&quot;&gt;Jacqueline Lesperance&lt;/a&gt;&lt;a id=&quot;xref-aff-1-4&quot; class=&quot;xref-aff&quot; href=&quot;#aff-1&quot;&gt;1&lt;/a&gt;,   &lt;a class=&quot;name-search&quot; href=&quot;/search?author1=John+Hassell&amp;sortspec=date&amp;submit=Submit&quot;&gt;John Hassell&lt;/a&gt;&lt;a id=&quot;xref-aff-1-5&quot; class=&quot;xref-aff&quot; href=&quot;#aff-1&quot;&gt;2&lt;/a&gt;,   &lt;a class=&quot;name-search&quot; href=&quot;/search?author1=Robert+G.+Oshima&amp;sortspec=date&amp;submit=Submit&quot;&gt;Robert G. Oshima&lt;/a&gt;&lt;a id=&quot;xref-aff-1-6&quot; class=&quot;xref-aff&quot; href=&quot;#aff-1&quot;&gt;1&lt;/a&gt;, and   &lt;a class=&quot;name-search&quot; href=&quot;/search?author1=Alexey+V.+Terskikh&amp;sortspec=date&amp;submit=Submit&quot;&gt;Alexey V. Terskikh&lt;/a&gt;&lt;a id=&quot;xref-aff-1-7&quot; class=&quot;xref-aff&quot; href=&quot;#aff-1&quot;&gt;1&lt;/a&gt;   &lt;a id=&quot;aff-1&quot; name=&quot;aff-1&quot;&gt;&lt;/a&gt;&lt;address&gt;&lt;strong&gt;Authors&#39; Affiliations:&lt;/strong&gt;1Tumor Development Program, Cancer Research Center, Sanford-Burnham Medical Research Institute, La Jolla, California and 2Center for Functional Genomics, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada     &lt;strong&gt;Corresponding Authors:&lt;/strong&gt;&lt;br /&gt; Robert G. Oshima or Alexey Terskikh, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037. Phone: 858-795-5299; Fax: 858-795-5298; E-mail: rgoshima{at}burnham.org or terskikh{at}burnham.org.     Current address for L. Hebbard: Westmead Millennium Institute, P.O. Box 412, Westmead NSW 2145, Australia.&lt;/p&gt;     &lt;strong&gt;Note:&lt;/strong&gt; R.G. Oshima and A. Terskikh contributed equally to this work. &lt;/p&gt;     Abstract Maternal embryonic leucine zipper kinase (MELK) is expressed in several developing tissues, in the adult germ line, and in adult neural progenitors. MELK expression is elevated in aggressive undifferentiated tumors, correlating with poor patient outcome in human breast cancer. To investigate the role of MELK in mammary tumorigenesis in vivo&lt;/em&gt;, we used a MELK-green fluorescent protein (GFP) reporter mouse, which allows prospective isolation of MELK-expressing cells based on GFP fluorescence. We found that in the normal mammary gland, cells expressing high levels of MELK were enriched in proliferating cells that express markers of mammary progenitors. The isolation of cells with high levels of MELK in mammary tumors from MMTV-Wnt1/MELK-GFP bitransgenic mice resulted in a significant enrichment of tumorsphere formation in culture and tumor initiation after transplantation into mammary fat pads of syngeneic mice. Furthermore, using lentiviral delivery of MELK-specific shRNA and limiting dilution cell transplantations, we showed that MELK function is required for mammary tumorigenesis in vivo&lt;/em&gt;. Our findings identify MELK as a potential target in breast tumor-initiating cells. Cancer Res; 70(21); 8863–73. ©2010 AACR. &lt;/p&gt;   Footnotes    Received April 14, 2010.  Revision received July 29, 2010.  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title=&quot;Table of Contents&quot;&gt;Table of Contents&lt;/a&gt;     This Article         Published OnlineFirst  September 22, 2010; doi: 10.1158/0008-5472.CAN-10-1295     &lt;abbr title=&quot;Cancer Research&quot; class=&quot;slug-jnl-abbrev&quot;&gt; Cancer Res November 1, 2010    70;   8863             » Abstract &lt;a href=&quot;/content/70/21/8863.full&quot; rel=&quot;view-full-text&quot;&gt;Full Text&lt;/a&gt; &lt;a href=&quot;/content/70/21/8863.full.pdf+html&quot; rel=&quot;view-full-text.pdf&quot;&gt;Full Text (PDF)&lt;/a&gt; &lt;a href=&quot;/content/70/21/8863/suppl/DC1&quot; rel=&quot;supplemental-data&quot; class=&quot;dslink-supplementary-data&quot;&gt;Supplementary Data&lt;/a&gt;  All Versions of this Article: &lt;a href=&quot;/content/early/2010/09/21/0008-5472.CAN-10-1295&quot;&gt;0008-5472.CAN-10-1295v1&lt;/a&gt; &lt;a href=&quot;/content/early/2010/10/21/0008-5472.CAN-10-1295&quot;&gt;0008-5472.CAN-10-1295v2&lt;/a&gt; 70/21/8863 most recent       Classifications    &lt;a class=&quot;tocsection-search&quot; 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href=&quot;#aff-1&quot;&gt;4&lt;/a&gt;,&lt;a id=&quot;xref-aff-1-15&quot; class=&quot;xref-aff&quot; href=&quot;#aff-1&quot;&gt;5&lt;/a&gt;   &lt;a id=&quot;aff-1&quot; name=&quot;aff-1&quot;&gt;&lt;/a&gt;&lt;address&gt;&lt;strong&gt;Authors&#39; Affiliations:&lt;/strong&gt;1Vall d&#39;Hebron Institute of Oncology; 2Statistics Department, Faculty of Biology, University of Barcelona; 3Statistic and Bioinformatics Unit, Institute of Research, Hospital Universitari Vall d&#39;Hebrón; 4Institució Catalana de Recerca i Estudis Avançats, Barcelona, Spain and 5Department of Biochemistry and Molecular Biology, Autonomous University of Barcelona, Bellaterra, Spain     &lt;strong&gt;Corresponding Author:&lt;/strong&gt;&lt;br /&gt; Joaquín Arribas, Medical Oncology Research Program, Vall d&#39;Hebron Institute of Oncology, Psg. Vall d&#39;Hebron 119-129, Barcelona 08035, Spain. Phone: 34-93-274-6026; Fax: 34-93-489-3884; E-mail: jarribas{at}vhio.net.     Abstract Current classification of breast cancers depends in great part on the expression of human epidermal growth factor receptor 2 (HER2), a cell surface tyrosine kinase receptor, and estrogen receptor (ER), the nuclear receptor for estrogen. In addition to reliable biomarkers, these receptors are targets of effective and widely used antitumor drugs. During malignant progression, HER2 and ER can establish an intricate cross-talk. In some cases, HER2 overexpression leads to the downregulation of ER and undermining of anti-ER therapies. A subgroup of HER2-positive breast cancer patients with poor prognosis expresses a heterogeneous collection of HER2 carboxy-terminal fragments (CTF) collectively known as p95HER2. One of these fragments, 611-CTF, is oncogenic in a variety of preclinical models. However, because of the lack of an appropriate tool to specifically analyze its levels in the clinical setting, the value of 611-CTF as a biomarker has not been established yet. Here, we show that 611-CTF induces resistance to antiestrogen therapy and a more pronounced down-modulation of ER than that induced by full-length HER2. To validate this effect in breast cancer samples, we developed specific anti–611-CTF antibodies. With these antibodies, we showed that, whereas the frequency of ER positivity in HER2-positive/611-CTF–negative tumors (72.6%) is similar to that reported for HER2-negative tumors (70–80%), the number of ER-positive tumors in the 611-CTF–positive subgroup is very low (31.2%). These results reveal a mechanism of ER regulation mediated by HER2, which suggests a new strategy to improve responses to endocrine therapy in breast cancer. Cancer Res; 70(21); 8537–46. ©2010 AACR. &lt;/p&gt;   Footnotes   &lt;strong&gt;Note:&lt;/strong&gt; Supplementary data for this article are available at Cancer Research Online (&lt;a href=&quot;http://cancerres.aacrjournals.org/&quot;&gt;http://cancerres.aacrjournals.org/&lt;/a&gt;). &lt;/p&gt;     Received May 27, 2010.  Revision received July 28, 2010.  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title=&quot;Table of Contents&quot;&gt;Table of Contents&lt;/a&gt;     This Article         Published OnlineFirst  October 26, 2010; doi: 10.1158/0008-5472.CAN-10-1701     &lt;abbr title=&quot;Cancer Research&quot; class=&quot;slug-jnl-abbrev&quot;&gt; Cancer Res November 1, 2010    70;   8537             » Abstract &lt;a href=&quot;/content/70/21/8537.full&quot; rel=&quot;view-full-text&quot;&gt;Full Text&lt;/a&gt; &lt;a href=&quot;/content/70/21/8537.full.pdf+html&quot; rel=&quot;view-full-text.pdf&quot;&gt;Full Text (PDF)&lt;/a&gt;  All Versions of this Article: &lt;a href=&quot;/content/early/2010/10/21/0008-5472.CAN-10-1701&quot;&gt;0008-5472.CAN-10-1701v1&lt;/a&gt; 70/21/8537 most recent       Classifications    &lt;a class=&quot;tocsection-search&quot; href=&quot;/search?tocsectionid=Molecular+and+Cellular+Pathobiology&amp;sortspec=date&amp;submit=Submit&quot;&gt;Molecular and Cellular Pathobiology&lt;/a&gt;      Services  &lt;a href=&quot;/email?gca=canres;70/21/8537&amp;current-view-path=/content/70/21/8537.short&quot;&gt; 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target=&quot;_blank&quot; rel=&quot;nofollow&quot;&gt;View the original article here&lt;/a&gt;&lt;/p&gt;</content><link rel='replies' type='application/atom+xml' href='http://nmdbreastcancerawareness.blogspot.com/feeds/4567650856988253609/comments/default' title='Post Comments'/><link rel='replies' type='text/html' href='http://nmdbreastcancerawareness.blogspot.com/2010/11/major-role-of-p95611-ctf-carboxy.html#comment-form' title='0 Comments'/><link rel='edit' type='application/atom+xml' href='http://www.blogger.com/feeds/763914643556275777/posts/default/4567650856988253609'/><link rel='self' type='application/atom+xml' href='http://www.blogger.com/feeds/763914643556275777/posts/default/4567650856988253609'/><link rel='alternate' type='text/html' href='http://nmdbreastcancerawareness.blogspot.com/2010/11/major-role-of-p95611-ctf-carboxy.html' title='A Major Role of p95/611-CTF, a Carboxy-Terminal Fragment of HER2, in the Down-modulation of the Estrogen Receptor in HER2-Positive Breast Cancers'/><author><name>Anonymous</name><uri>http://www.blogger.com/profile/14799558047407972898</uri><email>noreply@blogger.com</email><gd:image rel='http://schemas.google.com/g/2005#thumbnail' width='16' height='16' src='https://img1.blogblog.com/img/b16-rounded.gif'/></author><thr:total>0</thr:total></entry><entry><id>tag:blogger.com,1999:blog-763914643556275777.post-198790219061073400</id><published>2010-11-11T03:01:00.000-08:00</published><updated>2010-11-11T03:01:00.293-08:00</updated><category scheme="http://www.blogger.com/atom/ns#" term="Breast"/><category scheme="http://www.blogger.com/atom/ns#" term="Cancer"/><category scheme="http://www.blogger.com/atom/ns#" term="Encourage"/><category scheme="http://www.blogger.com/atom/ns#" term="Growth"/><category scheme="http://www.blogger.com/atom/ns#" term="Stress"/><title type='text'>Stress Can Encourage the Growth of Breast Cancer</title><content type='html'> &lt;BODY readability=&quot;0&quot;&gt;&lt;P&gt;New research has confirmed that chronic stress can in some cases&lt;STRONG&gt; &lt;/STRONG&gt;stimulate breast cancer progression. Researchers at UCLA&#39;s cancer center have shown in animals that, over time, stress significantly accelerates the spread of the disease.  &lt;/P&gt;&lt;P&gt;Note that I said chronic&lt;/EM&gt; stress, not merely a single bad day or episode of unpleasantness.  &lt;/P&gt;&lt;P&gt;The scientists discovered that chronic stress actually biologically reprograms our usually friendly immune cells so that, instead of attacking the enemy cells, they start helping them survive and thrive. &lt;/P&gt;&lt;P&gt;This animal research study, performed at UCLA and published in the September 2010 Cancer Research Journal&lt;/EM&gt;, revealed that highly stressed mice had 30 times&lt;/EM&gt; (!) more cancer cells in their bodies than did the mice who were not exposed to the stressful environment. Now, that&#39;s a significant difference.&lt;/P&gt;&lt;P&gt;So, even if we might not be able to fix or put right all the things that are giving us grief right now, just knowing about these study results will perhaps motivate us to start learning some new, emotionally healthier ways to react to stressors, such as (just off the top of my head) yoga classes, deep breathing and relaxation exercises, psychotherapy, and stress-management seminars. Who knows? Learning some emotionally healthier ways of dealing with life&#39;s aggravations might be easier than we think. &lt;/P&gt;&lt;br /&gt;&lt;p&gt;&lt;a href=&quot;http://www.medworm.com/index.php?rid=4117746&amp;cid=c_2_91_f&amp;fid=34601&amp;url=http%3A%2F%2Fhealth.yahoo.net%2Fexperts%2Fbreastcancer%2Fstress-can-encourage-growth-breast-cancer&quot; target=&quot;_blank&quot; rel=&quot;nofollow&quot;&gt;View the original article here&lt;/a&gt;&lt;/p&gt;</content><link rel='replies' type='application/atom+xml' href='http://nmdbreastcancerawareness.blogspot.com/feeds/198790219061073400/comments/default' title='Post Comments'/><link rel='replies' type='text/html' href='http://nmdbreastcancerawareness.blogspot.com/2010/11/stress-can-encourage-growth-of-breast.html#comment-form' title='0 Comments'/><link rel='edit' type='application/atom+xml' href='http://www.blogger.com/feeds/763914643556275777/posts/default/198790219061073400'/><link rel='self' type='application/atom+xml' href='http://www.blogger.com/feeds/763914643556275777/posts/default/198790219061073400'/><link rel='alternate' type='text/html' href='http://nmdbreastcancerawareness.blogspot.com/2010/11/stress-can-encourage-growth-of-breast.html' title='Stress Can Encourage the Growth of Breast Cancer'/><author><name>Anonymous</name><uri>http://www.blogger.com/profile/14799558047407972898</uri><email>noreply@blogger.com</email><gd:image rel='http://schemas.google.com/g/2005#thumbnail' width='16' height='16' src='https://img1.blogblog.com/img/b16-rounded.gif'/></author><thr:total>0</thr:total></entry><entry><id>tag:blogger.com,1999:blog-763914643556275777.post-8097811227472236677</id><published>2010-11-10T20:31:00.000-08:00</published><updated>2010-11-10T20:31:00.356-08:00</updated><category scheme="http://www.blogger.com/atom/ns#" term="Breast"/><category scheme="http://www.blogger.com/atom/ns#" term="Cancer"/><category scheme="http://www.blogger.com/atom/ns#" term="Disparities"/><category scheme="http://www.blogger.com/atom/ns#" term="NSABP"/><category scheme="http://www.blogger.com/atom/ns#" term="Treatment"/><category scheme="http://www.blogger.com/atom/ns#" term="World"/><title type='text'>Disparities in Breast Cancer Treatment: NSABP vs Real World</title><content type='html'> In order to use Medscape, your browser must be set to accept cookies delivered by the Medscape site. To find out how to adjust your browser settings to accept cookies, please &lt;A onclick=&quot;resizeWin(&#39;Figure&#39;,400,520)&quot; href=&quot;about:www.medscape.com/pjsp/public/help/registration/allowcookies.html&quot; target=Figure&gt;click here&lt;/A&gt;. &lt;P&gt;Medscape uses cookies to customize the site based on the information we collect at registration. The cookies contain no personally identifiable information and have no effect once you leave the Medscape site. You can read more about our use of cookies in our &lt;A onclick=&quot;resizeWin(&#39;Figure&#39;,400,520)&quot; href=&quot;about:www.medscape.com/pjsp/public/privacy.html&quot; target=Figure&gt;privacy policy&lt;/A&gt;.&lt;/P&gt;&lt;br /&gt;&lt;p&gt;&lt;a href=&quot;http://www.medworm.com/index.php?rid=4123627&amp;cid=c_2_26_f&amp;fid=36062&amp;url=http%3A%2F%2Fwww.medscape.com%2Fviewarticle%2F731704%3Fsrc%3Drss&quot; target=&quot;_blank&quot; rel=&quot;nofollow&quot;&gt;View the original article here&lt;/a&gt;&lt;/p&gt;</content><link rel='replies' type='application/atom+xml' href='http://nmdbreastcancerawareness.blogspot.com/feeds/8097811227472236677/comments/default' title='Post Comments'/><link rel='replies' type='text/html' href='http://nmdbreastcancerawareness.blogspot.com/2010/11/disparities-in-breast-cancer-treatment.html#comment-form' title='0 Comments'/><link rel='edit' type='application/atom+xml' href='http://www.blogger.com/feeds/763914643556275777/posts/default/8097811227472236677'/><link rel='self' type='application/atom+xml' href='http://www.blogger.com/feeds/763914643556275777/posts/default/8097811227472236677'/><link rel='alternate' type='text/html' href='http://nmdbreastcancerawareness.blogspot.com/2010/11/disparities-in-breast-cancer-treatment.html' title='Disparities in Breast Cancer Treatment: NSABP vs Real World'/><author><name>Anonymous</name><uri>http://www.blogger.com/profile/14799558047407972898</uri><email>noreply@blogger.com</email><gd:image rel='http://schemas.google.com/g/2005#thumbnail' width='16' height='16' src='https://img1.blogblog.com/img/b16-rounded.gif'/></author><thr:total>0</thr:total></entry><entry><id>tag:blogger.com,1999:blog-763914643556275777.post-2492563622012058847</id><published>2010-11-10T11:23:00.000-08:00</published><updated>2010-11-10T11:23:00.885-08:00</updated><category scheme="http://www.blogger.com/atom/ns#" term="Breast"/><category scheme="http://www.blogger.com/atom/ns#" term="Cancer"/><category scheme="http://www.blogger.com/atom/ns#" term="Certain"/><category scheme="http://www.blogger.com/atom/ns#" term="contraceptive"/><category scheme="http://www.blogger.com/atom/ns#" term="formulations"/><category scheme="http://www.blogger.com/atom/ns#" term="Linked"/><category scheme="http://www.blogger.com/atom/ns#" term="still"/><title type='text'>Certain oral contraceptive formulations still linked to breast cancer risk</title><content type='html'> &lt;BODY readability=&quot;0&quot;&gt;&lt;P&gt;MedWire News: Current use of oral contraceptives is associated with a moderately increased risk for breast cancer, which is mainly attributed to levonorgestrel used in triphasic preparations, show results from the Nurses Health study II.&lt;/P&gt;&lt;P&gt;Past use of levonorgestrel-containing triphasic contraceptives and current and past use of other formulations was not associated with a significantly increased breast cancer risk, the researchers remark.&lt;/P&gt;&lt;P&gt;&quot;Previous studies convincingly showed an increase in risk for breast cancer associated with current or recent use of oral contraceptives from the 1960s to 1980s,&quot; note David Hunter (Harvard Medical School, Boston, Massachusetts, USA) and colleagues.&lt;/P&gt;&lt;P&gt;To assess the association of contemporary oral contraceptive formulations with breast cancer risk, Hunter and team analyzed data from 116,608 female nurses aged 25-42 years at study enrollment in 1989. Information on contraceptive use was subsequently updated every 2 years and the risk for breast cancer was examined up to June 2001.&lt;/P&gt;&lt;P&gt;The researchers report that during 1,246,967 person-years of follow-up, 1,344 cases of invasive breast cancer were diagnosed.&lt;/P&gt;&lt;P&gt;Past use of any oral contraceptive was not significantly related to breast cancer risk (relative risk=1.12], whereas current use of any oral contraceptive was related to a marginally significant 1.33-fold increased risk for breast cancer.&lt;/P&gt;&lt;P&gt;When the researchers analyzed the data according to the type of progestin formulation used, they found that current users of triphasic ethinyl estradiol combined with levonorgestrel - commonly prescribed in the 1990s - had a significant 3.05-fold increased risk for breast cancer, compared with women who had never used oral contraceptives.&lt;/P&gt;&lt;P&gt;The age-standardized incidence of breast cancer among never-users of oral contraceptives was 98 per 100,000 person-years compared with 227 per 100,000 person-years among current users of the triphasic ethinyl estradiol plus levonorgestrel formulation.&lt;/P&gt;&lt;P&gt;Of note, the most commonly used triphasic formulation contains norethindrone as the progestin rather than levonorgestrel, and this was not associated with an increased breast cancer risk. There was also no increased risk for levonorgestrel-containing nontriphasic formulations.&lt;/P&gt;&lt;P&gt;Hunter and co-authors conclude that their findings suggest &quot;different oral contraceptive formulations might convey different risks of breast cancer.&quot;&lt;/P&gt;&lt;P&gt;&quot;Ongoing monitoring of these associations is necessary as oral contraceptive formulations change,&quot; they add in the journal Cancer Epidemiology Biomarkers and Prevention.&lt;/P&gt;&lt;P&gt;MedWire (www.medwire-news.md) is an independent clinical news service provided by Current Medicine Group, a trading division of Springer Healthcare Limited. © Springer Healthcare Ltd; 2010&lt;/P&gt;&lt;P&gt;&lt;A class=date href=&quot;http://cebp.aacrjournals.org/content/19/10/2496&quot; target=&quot;_blank&quot;&gt;Free abstract &lt;/A&gt;&lt;/P&gt;&lt;A href=&quot;about:blank#comment&quot;&gt;&lt;IMG class=bt_sec border=0 src=&quot;/comment.gif&quot;&gt;&lt;/A&gt;&lt;br /&gt;&lt;p&gt;&lt;a href=&quot;http://www.medworm.com/index.php?rid=4109654&amp;cid=c_2_6_f&amp;fid=36308&amp;url=http%3A%2F%2Fwww.medwire-news.md%2F380%2F89852%2FBreast_Cancer%2FCertain_oral_contraceptive_formulations_still_linked_to_breast_cancer_risk.html&quot; target=&quot;_blank&quot; rel=&quot;nofollow&quot;&gt;View the original article here&lt;/a&gt;&lt;/p&gt;</content><link rel='replies' type='application/atom+xml' href='http://nmdbreastcancerawareness.blogspot.com/feeds/2492563622012058847/comments/default' title='Post Comments'/><link rel='replies' type='text/html' href='http://nmdbreastcancerawareness.blogspot.com/2010/11/certain-oral-contraceptive-formulations.html#comment-form' title='0 Comments'/><link rel='edit' type='application/atom+xml' href='http://www.blogger.com/feeds/763914643556275777/posts/default/2492563622012058847'/><link rel='self' type='application/atom+xml' href='http://www.blogger.com/feeds/763914643556275777/posts/default/2492563622012058847'/><link rel='alternate' type='text/html' href='http://nmdbreastcancerawareness.blogspot.com/2010/11/certain-oral-contraceptive-formulations.html' title='Certain oral contraceptive formulations still linked to breast cancer risk'/><author><name>Anonymous</name><uri>http://www.blogger.com/profile/14799558047407972898</uri><email>noreply@blogger.com</email><gd:image rel='http://schemas.google.com/g/2005#thumbnail' width='16' height='16' src='https://img1.blogblog.com/img/b16-rounded.gif'/></author><thr:total>0</thr:total></entry><entry><id>tag:blogger.com,1999:blog-763914643556275777.post-63191789106640506</id><published>2010-11-10T03:22:00.000-08:00</published><updated>2010-11-10T03:22:00.252-08:00</updated><category scheme="http://www.blogger.com/atom/ns#" term="Analysis"/><category scheme="http://www.blogger.com/atom/ns#" term="Behaviors"/><category scheme="http://www.blogger.com/atom/ns#" term="Breast"/><category scheme="http://www.blogger.com/atom/ns#" term="Cancer"/><category scheme="http://www.blogger.com/atom/ns#" term="Contribution"/><category scheme="http://www.blogger.com/atom/ns#" term="Daily"/><category scheme="http://www.blogger.com/atom/ns#" term="Dysfunctional"/><category scheme="http://www.blogger.com/atom/ns#" term="Inhibitory"/><category scheme="http://www.blogger.com/atom/ns#" term="Insomnia"/><category scheme="http://www.blogger.com/atom/ns#" term="Process"/><category scheme="http://www.blogger.com/atom/ns#" term="Related"/><category scheme="http://www.blogger.com/atom/ns#" term="Sleep"/><category scheme="http://www.blogger.com/atom/ns#" term="survivors"/><category scheme="http://www.blogger.com/atom/ns#" term="Symptoms"/><category scheme="http://www.blogger.com/atom/ns#" term="Thoughts"/><title type='text'>Contribution of Cancer Symptoms, Dysfunctional Sleep Related Thoughts, and Sleep Inhibitory Behaviors to the Insomnia Process in Breast Cancer Survivors: A Daily Process Analysis</title><content type='html'> &lt;BODY readability=&quot;0&quot;&gt;&lt;P&gt;&lt;B&gt;CANCER SYMPTOMS AND INSOMNIA IN BREAST CANCER SURVIVORS&lt;/B&gt;&lt;BR&gt;Contribution of Cancer Symptoms, Dysfunctional Sleep Related Thoughts, and Sleep Inhibitory Behaviors to the Insomnia Process in Breast Cancer Survivors: A Daily Process Analysis &lt;P&gt;Meredith E. Rumble, PhD1; Francis J. Keefe, PhD2; Jack D. Edinger, PhD2,3; Glenn Affleck, PhD4; P. Kelly Marcom, MD2; Heather S. Shaw, MD5&lt;/P&gt;&lt;P&gt;1University of Wisconsin, Madison, WI; 2Duke University Medical Center, Durham, NC; 3VA Medical Center, Durham, NC; 4University of Connecticut Health Center, Farmington, CT; 5University of North Carolina, Chapel Hill, NC&lt;/EM&gt;&lt;/P&gt;&lt;BR&gt;&lt;BR&gt;&lt;A href=&quot;about:ViewAbstract.aspx?pid=27947&quot;&gt;Editor&#39;s Note. 1425.&lt;/A&gt; &lt;BR&gt;David F. Dinges, PhD &lt;A href=&quot;about:ViewAbstract.aspx?pid=27949&quot;&gt;Post-H1N1 Narcolepsy-Cataplexy. 1428-1430.&lt;/A&gt; &lt;BR&gt;Yves Dauvilliers, MD, PhD1; Jacques Montplaisir, MD, PhD2,3; Valéerie Cochen, MD, PhD1; Alex Desautels, MD2,4; Mali Einen, BA5; Ling Lin, MD, PhD5; Minae Kawashima, PhD5; Sophie Bayard, PhD1; Christelle Monaca, MD, PhD6; Michel Tiberge, MD7; Daniel Filipini, MD2; Asit Tripathy, MD8; Bich Hong Nguyen, MD1,9; Suresh Kotagal, MD10; Emmanuel Mignot, MD, PhD5 &lt;A href=&quot;about:ViewAbstract.aspx?pid=27953&quot;&gt;Intermittent Hypoxia Mobilizes Bone Marrow-Derived Very Small Embryonic-Like Stem Cells and Activates Developmental Transcriptional Programs in Mice. 1439-1446.&lt;/A&gt; &lt;BR&gt;Sina A. Gharib, MD1; Ehab A. Dayyat, MD2; Abdelnaby Khalyfa, PhD2,4; Jinkwan Kim, PhD2,4; Heather B. Clair, MSc2; Magdalena Kucia, PhD3; David Gozal, MD2,4 &lt;A href=&quot;about:ViewAbstract.aspx?pid=27955&quot;&gt;Clinical and Therapeutic Aspects of Childhood Narcolepsy-Cataplexy: A Retrospective Study of 51 Children. 1457-1464.&lt;/A&gt; &lt;IMG id=ctl00_ContentPlaceHolder1_IssueNavigator1_PublishedArticleRepeater_ctl09_CMEImage title=&quot;Article Is Eligible For CME Credits&quot; border=0 alt=&quot;Article Is Eligible For CME Credits&quot; src=&quot;/cme.gif&quot;&gt;&lt;BR&gt;Adi Aran, MD1; Mali Einen2; Ling Lin, MD, PhD2; Guiseppe Plazzi, MD3; Seiji Nishino, MD, PhD2; Emmanuel Mignot, MD, PhD2 &lt;A href=&quot;about:ViewAbstract.aspx?pid=27956&quot;&gt;Coping with Sleep Deprivation: Shifts in Regional Brain Activity and Learning Strategy. 1465-1473.&lt;/A&gt; &lt;BR&gt;Roelina Hagewoud1; Robbert Havekes, PhD1; Paula A. Tiba, PhD2; Arianna Novati1; Koen Hogenelst1; Pim Weinreder1; Eddy A. Van der Zee, PhD1; Peter Meerlo, PhD1 &lt;A href=&quot;about:ViewAbstract.aspx?pid=27959&quot;&gt;Positive Airway Pressure Adherence in Veterans with Posttraumatic Stress Disorder. 1495-1500.&lt;/A&gt; &lt;BR&gt;Ali A. El-Solh, MD, MPH1,2,3; Lakshmy Ayyar, MD2; Morohonfolu Akinnusi, MD2; Sachin Relia, MD4; Opeoluwa Akinnusi, MD4 &lt;A href=&quot;about:ViewAbstract.aspx?pid=27961&quot;&gt;Analysis of Slow-Wave Activity and Slow-Wave Oscillations Prior to Somnambulism. 1511-1516.&lt;/A&gt; &lt;BR&gt;Olivier Jaar1,2; Mathieu Pilon, PhD1,2; Julie Carrier, PhD1,2; Jacques Montplaisir, MD, PhD, CRCPc1,3; Antonio Zadra, PhD1,2 &lt;A href=&quot;about:ViewAbstract.aspx?pid=27963&quot;&gt;Motor Unit Recruitment in Human Genioglossus Muscle in Response to Hypercapnia. 1529-1538.&lt;/A&gt; &lt;BR&gt;Christian L. Nicholas, PhD1; Bei Bei, DPsych1; Christopher Worsnop, MBBS, PhD1; Atul Malhotra, MD2; Amy S. Jordan, PhD1; Julian P. Saboisky, PhD2; Julia K. M. Chan, BA (Hons)1; Ella Duckworth, BSc (Hons)1; David P. White, MD2; John Trinder, PhD1 &lt;A href=&quot;about:ViewAbstract.aspx?pid=27964&quot;&gt;Reliability and Validity of the Brief Insomnia Questionnaire in the America Insomnia Survey. 1539-1549.&lt;/A&gt; &lt;BR&gt;Ronald C. Kessler, PhD1; Catherine Coulouvrat, MD2; Goeran Hajak, MD3; Matthew D. Lakoma, MPH1; Thomas Roth, PhD4; Nancy Sampson, BA1; Victoria Shahly, PhD1; Alicia Shillington, PhD5; Judith J. Stephenson, SM6; James K. Walsh, PhD7; Gary K. Zammit, PhD8 &lt;A href=&quot;about:ViewAbstract.aspx?pid=27965&quot;&gt;Efficacy and Safety of Doxepin 1 mg and 3 mg in a 12-week Sleep Laboratory and Outpatient Trial of Elderly Subjects with Chronic Primary Insomnia. 1553-1561.&lt;/A&gt; &lt;BR&gt;Andrew D. Krystal, MD, MS1; H. Heith Durrence, PhD2; Martin Scharf, PhD3; Philip Jochelson, MD4; Roberta Rogowski, BSN2; Elizabeth Ludington, PhD2; Thomas Roth, PhD5 &lt;A href=&quot;about:ViewAbstract.aspx?pid=27966&quot;&gt;Alterations in Cyclic Alternating Pattern Associated with Phase Advanced Sleep are Differentially Modulated by Gaboxadol and Zolpidem. 1562-1570.&lt;/A&gt; &lt;BR&gt;Vladimir Svetnik, PhD1; Raffaele Ferri, MD2; Shubhankar Ray, PhD1; Junshui Ma, PhD1; James K. Walsh, PhD3,4; Ellen Snyder, PhD5; Bjarke Ebert, PhD, DSc6; Steve Deacon, PhD7 &lt;IMG alt=Expand src=&quot;/iconarrow1.gif&quot;&gt;  Table of Contents     &lt;A name=d7e166&gt;&lt;/A&gt;Using a comprehensive cognitive-behavioral model of insomnia and a daily process approach, this study was conducted to examine the contribution of cancer symptoms and dysfunctional sleep related thoughts and behaviors to the process of insomnia in breast cancer survivors.&lt;/P&gt;&lt;A name=d7e171&gt;&lt;/A&gt;Within-group longitudinal research design.&lt;/P&gt;&lt;A name=d7e181&gt;&lt;/A&gt;41 women with breast cancer who had completed their primary cancer treatment and met Research Diagnostic Criteria for primary insomnia or insomnia comorbid with breast cancer.&lt;/P&gt;&lt;A name=d7e191&gt;&lt;/A&gt;For 28 days, participants completed morning diaries assessing sleep, nighttime pain and hot flashes, and dysfunctional sleep related thoughts and behaviors during the day and night, and evening diaries assessing daytime pain, fatigue, hot flashes, and mood. All diaries were collected using an automated telephone-based system. Results revealed that poorer sleep was related to nighttime pain and hot flashes in breast cancer patients. Time-lagged effects were also found. The current study identified higher levels of dysfunctional sleep related thoughts and sleep inhibitory behaviors during the day and night as antecedents of insomnia, and higher levels of pain, fatigue, and hot flashes and lower levels of positive mood and dysfunctional sleep related thoughts as consequences of insomnia in this population.&lt;/P&gt;&lt;A name=d7e196&gt;&lt;/A&gt;The current study found support for a comprehensive cognitive-behavioral model of insomnia, which has several theoretical, practice, and research implications.&lt;/P&gt;&lt;A name=d7e201&gt;&lt;/A&gt;Rumble ME; Keefe FJ; Edinger JD; Affleck G; Marcom PK; Shaw HS. Contribution of cancer symptoms, dysfunctional sleep related thoughts, and sleep inhibitory behaviors to the insomnia process in breast cancer survivors: a daily process analysis. SLEEP 2010;33(11):1501-1509.&lt;/P&gt;&lt;BR&gt;&lt;BR&gt;&lt;A href=&quot;about:ViewAbstract.aspx?pid=27947&quot;&gt;Editor&#39;s Note. 1425.&lt;/A&gt; &lt;BR&gt;David F. Dinges, PhD &lt;A href=&quot;about:ViewAbstract.aspx?pid=27949&quot;&gt;Post-H1N1 Narcolepsy-Cataplexy. 1428-1430.&lt;/A&gt; &lt;BR&gt;Yves Dauvilliers, MD, PhD1; Jacques Montplaisir, MD, PhD2,3; Valéerie Cochen, MD, PhD1; Alex Desautels, MD2,4; Mali Einen, BA5; Ling Lin, MD, PhD5; Minae Kawashima, PhD5; Sophie Bayard, PhD1; Christelle Monaca, MD, PhD6; Michel Tiberge, MD7; Daniel Filipini, MD2; Asit Tripathy, MD8; Bich Hong Nguyen, MD1,9; Suresh Kotagal, MD10; Emmanuel Mignot, MD, PhD5 &lt;A href=&quot;about:ViewAbstract.aspx?pid=27953&quot;&gt;Intermittent Hypoxia Mobilizes Bone Marrow-Derived Very Small Embryonic-Like Stem Cells and Activates Developmental Transcriptional Programs in Mice. 1439-1446.&lt;/A&gt; &lt;BR&gt;Sina A. Gharib, MD1; Ehab A. Dayyat, MD2; Abdelnaby Khalyfa, PhD2,4; Jinkwan Kim, PhD2,4; Heather B. Clair, MSc2; Magdalena Kucia, PhD3; David Gozal, MD2,4 &lt;A href=&quot;about:ViewAbstract.aspx?pid=27955&quot;&gt;Clinical and Therapeutic Aspects of Childhood Narcolepsy-Cataplexy: A Retrospective Study of 51 Children. 1457-1464.&lt;/A&gt; &lt;IMG id=ctl00_ContentPlaceHolder1_IssueNavigator2_PublishedArticleRepeater_ctl09_CMEImage title=&quot;Article Is Eligible For CME Credits&quot; border=0 alt=&quot;Article Is Eligible For CME Credits&quot; src=&quot;/cme.gif&quot;&gt;&lt;BR&gt;Adi Aran, MD1; Mali Einen2; Ling Lin, MD, PhD2; Guiseppe Plazzi, MD3; Seiji Nishino, MD, PhD2; Emmanuel Mignot, MD, PhD2 &lt;A href=&quot;about:ViewAbstract.aspx?pid=27956&quot;&gt;Coping with Sleep Deprivation: Shifts in Regional Brain Activity and Learning Strategy. 1465-1473.&lt;/A&gt; &lt;BR&gt;Roelina Hagewoud1; Robbert Havekes, PhD1; Paula A. Tiba, PhD2; Arianna Novati1; Koen Hogenelst1; Pim Weinreder1; Eddy A. Van der Zee, PhD1; Peter Meerlo, PhD1 &lt;A href=&quot;about:ViewAbstract.aspx?pid=27959&quot;&gt;Positive Airway Pressure Adherence in Veterans with Posttraumatic Stress Disorder. 1495-1500.&lt;/A&gt; &lt;BR&gt;Ali A. El-Solh, MD, MPH1,2,3; Lakshmy Ayyar, MD2; Morohonfolu Akinnusi, MD2; Sachin Relia, MD4; Opeoluwa Akinnusi, MD4 &lt;A href=&quot;about:ViewAbstract.aspx?pid=27961&quot;&gt;Analysis of Slow-Wave Activity and Slow-Wave Oscillations Prior to Somnambulism. 1511-1516.&lt;/A&gt; &lt;BR&gt;Olivier Jaar1,2; Mathieu Pilon, PhD1,2; Julie Carrier, PhD1,2; Jacques Montplaisir, MD, PhD, CRCPc1,3; Antonio Zadra, PhD1,2 &lt;A href=&quot;about:ViewAbstract.aspx?pid=27963&quot;&gt;Motor Unit Recruitment in Human Genioglossus Muscle in Response to Hypercapnia. 1529-1538.&lt;/A&gt; &lt;BR&gt;Christian L. Nicholas, PhD1; Bei Bei, DPsych1; Christopher Worsnop, MBBS, PhD1; Atul Malhotra, MD2; Amy S. Jordan, PhD1; Julian P. Saboisky, PhD2; Julia K. M. Chan, BA (Hons)1; Ella Duckworth, BSc (Hons)1; David P. White, MD2; John Trinder, PhD1 &lt;A href=&quot;about:ViewAbstract.aspx?pid=27964&quot;&gt;Reliability and Validity of the Brief Insomnia Questionnaire in the America Insomnia Survey. 1539-1549.&lt;/A&gt; &lt;BR&gt;Ronald C. Kessler, PhD1; Catherine Coulouvrat, MD2; Goeran Hajak, MD3; Matthew D. Lakoma, MPH1; Thomas Roth, PhD4; Nancy Sampson, BA1; Victoria Shahly, PhD1; Alicia Shillington, PhD5; Judith J. Stephenson, SM6; James K. Walsh, PhD7; Gary K. Zammit, PhD8 &lt;A href=&quot;about:ViewAbstract.aspx?pid=27965&quot;&gt;Efficacy and Safety of Doxepin 1 mg and 3 mg in a 12-week Sleep Laboratory and Outpatient Trial of Elderly Subjects with Chronic Primary Insomnia. 1553-1561.&lt;/A&gt; &lt;BR&gt;Andrew D. Krystal, MD, MS1; H. Heith Durrence, PhD2; Martin Scharf, PhD3; Philip Jochelson, MD4; Roberta Rogowski, BSN2; Elizabeth Ludington, PhD2; Thomas Roth, PhD5 &lt;A href=&quot;about:ViewAbstract.aspx?pid=27966&quot;&gt;Alterations in Cyclic Alternating Pattern Associated with Phase Advanced Sleep are Differentially Modulated by Gaboxadol and Zolpidem. 1562-1570.&lt;/A&gt; &lt;BR&gt;Vladimir Svetnik, PhD1; Raffaele Ferri, MD2; Shubhankar Ray, PhD1; Junshui Ma, PhD1; James K. Walsh, PhD3,4; Ellen Snyder, PhD5; Bjarke Ebert, PhD, DSc6; Steve Deacon, PhD7 &lt;IMG alt=Expand src=&quot;/iconarrow2.gif&quot;&gt;  Table of Contents &lt;IMG src=&quot;/ajax-loader.gif&quot;&gt; &lt;BR&gt;Please wait... &lt;br /&gt;&lt;p&gt;&lt;a href=&quot;http://www.medworm.com/index.php?rid=4117947&amp;cid=c_2_146_f&amp;fid=36335&amp;url=http%3A%2F%2Fwww.journalsleep.org%2FViewAbstract.aspx%3Fpid%3D27960&quot; target=&quot;_blank&quot; rel=&quot;nofollow&quot;&gt;View the original article here&lt;/a&gt;&lt;/p&gt;</content><link rel='replies' type='application/atom+xml' href='http://nmdbreastcancerawareness.blogspot.com/feeds/63191789106640506/comments/default' title='Post Comments'/><link rel='replies' type='text/html' href='http://nmdbreastcancerawareness.blogspot.com/2010/11/contribution-of-cancer-symptoms.html#comment-form' title='0 Comments'/><link rel='edit' type='application/atom+xml' href='http://www.blogger.com/feeds/763914643556275777/posts/default/63191789106640506'/><link rel='self' type='application/atom+xml' href='http://www.blogger.com/feeds/763914643556275777/posts/default/63191789106640506'/><link rel='alternate' type='text/html' href='http://nmdbreastcancerawareness.blogspot.com/2010/11/contribution-of-cancer-symptoms.html' title='Contribution of Cancer Symptoms, Dysfunctional Sleep Related Thoughts, and Sleep Inhibitory Behaviors to the Insomnia Process in Breast Cancer Survivors: A Daily Process Analysis'/><author><name>Anonymous</name><uri>http://www.blogger.com/profile/14799558047407972898</uri><email>noreply@blogger.com</email><gd:image rel='http://schemas.google.com/g/2005#thumbnail' width='16' height='16' src='https://img1.blogblog.com/img/b16-rounded.gif'/></author><thr:total>0</thr:total></entry><entry><id>tag:blogger.com,1999:blog-763914643556275777.post-8000060991934080906</id><published>2010-11-09T18:45:00.000-08:00</published><updated>2010-11-09T18:45:00.681-08:00</updated><category scheme="http://www.blogger.com/atom/ns#" term="Breast"/><category scheme="http://www.blogger.com/atom/ns#" term="Cancer"/><category scheme="http://www.blogger.com/atom/ns#" term="Community"/><category scheme="http://www.blogger.com/atom/ns#" term="Consortium"/><category scheme="http://www.blogger.com/atom/ns#" term="Equipment"/><category scheme="http://www.blogger.com/atom/ns#" term="Facilities"/><category scheme="http://www.blogger.com/atom/ns#" term="Imaging"/><category scheme="http://www.blogger.com/atom/ns#" term="Practice"/><category scheme="http://www.blogger.com/atom/ns#" term="Surveillance"/><category scheme="http://www.blogger.com/atom/ns#" term="Techniques"/><title type='text'>Breast MRI in Community Practice: Equipment and Imaging Techniques at Facilities in the Breast Cancer Surveillance Consortium</title><content type='html'> European Online Customer Service&lt;BR&gt;The Boulevard&lt;BR&gt;Langford Lane, Kidlington&lt;BR&gt;Oxford. 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&lt;a href=&quot;http://www.aacr.org/&quot; title=&quot;AACR Home&quot;&gt;AACR Home&lt;/a&gt;        Search GO   &lt;a href=&quot;/search&quot;&gt;Advanced Search&lt;/a&gt;                      User Name  Password   Sign In                              &lt;a href=&quot;/cgi/adclick/?ad=25343&amp;adclick=true&amp;url=http%3A%2F%2Fwww.aacr.org%2Fmembership&quot;&gt;&lt;img class=&quot;adborder0&quot; title=&quot;AACR Membership&quot; src=&quot;http://cancerres.aacrjournals.org/adsystem/graphics/887661513443255/canres/Member2_430x90.jpg?ad=25343&amp;adview=true&quot; alt=&quot;AACR Membership&quot; /&gt;&lt;/a&gt; &lt;a href=&quot;/cgi/adclick/?ad=24926&amp;adclick=true&amp;url=http%3A%2F%2Fwww.cancercareers.org&quot;&gt;&lt;img class=&quot;adborder0&quot; title=&quot;Cancer Careers&quot; src=&quot;http://cancerres.aacrjournals.org/adsystem/graphics/7868860759077497/canres/cancercareers430x90.jpg?ad=24926&amp;adview=true&quot; alt=&quot;Cancer Careers&quot; /&gt;&lt;/a&gt;       Cdc42-Interacting Protein 4 Promotes Breast Cancer Cell Invasion and Formation of Invadopodia through Activation of N-WASp   &lt;a class=&quot;name-search&quot; href=&quot;/search?author1=Christina+S.+Pichot&amp;sortspec=date&amp;submit=Submit&quot;&gt;Christina S. Pichot&lt;/a&gt;&lt;a id=&quot;xref-aff-1-1&quot; class=&quot;xref-aff&quot; href=&quot;#aff-1&quot;&gt;1&lt;/a&gt;,   &lt;a class=&quot;name-search&quot; href=&quot;/search?author1=Constadina+Arvanitis&amp;sortspec=date&amp;submit=Submit&quot;&gt;Constadina Arvanitis&lt;/a&gt;&lt;a id=&quot;xref-aff-1-2&quot; class=&quot;xref-aff&quot; href=&quot;#aff-1&quot;&gt;3&lt;/a&gt;,   &lt;a class=&quot;name-search&quot; href=&quot;/search?author1=Sean+M.+Hartig&amp;sortspec=date&amp;submit=Submit&quot;&gt;Sean M. Hartig&lt;/a&gt;&lt;a id=&quot;xref-aff-1-3&quot; class=&quot;xref-aff&quot; href=&quot;#aff-1&quot;&gt;2&lt;/a&gt;,   &lt;a class=&quot;name-search&quot; href=&quot;/search?author1=Samuel+A.+Jensen&amp;sortspec=date&amp;submit=Submit&quot;&gt;Samuel A. Jensen&lt;/a&gt;&lt;a id=&quot;xref-aff-1-4&quot; class=&quot;xref-aff&quot; href=&quot;#aff-1&quot;&gt;3&lt;/a&gt;,   &lt;a class=&quot;name-search&quot; href=&quot;/search?author1=John+Bechill&amp;sortspec=date&amp;submit=Submit&quot;&gt;John Bechill&lt;/a&gt;&lt;a id=&quot;xref-aff-1-5&quot; class=&quot;xref-aff&quot; href=&quot;#aff-1&quot;&gt;3&lt;/a&gt;,   &lt;a class=&quot;name-search&quot; href=&quot;/search?author1=Saad+Marzouk&amp;sortspec=date&amp;submit=Submit&quot;&gt;Saad Marzouk&lt;/a&gt;&lt;a id=&quot;xref-aff-1-6&quot; class=&quot;xref-aff&quot; href=&quot;#aff-1&quot;&gt;3&lt;/a&gt;,   &lt;a class=&quot;name-search&quot; href=&quot;/search?author1=Jindan+Yu&amp;sortspec=date&amp;submit=Submit&quot;&gt;Jindan Yu&lt;/a&gt;&lt;a id=&quot;xref-aff-1-7&quot; class=&quot;xref-aff&quot; href=&quot;#aff-1&quot;&gt;4&lt;/a&gt;,   &lt;a class=&quot;name-search&quot; href=&quot;/search?author1=Jeffrey+A.+Frost&amp;sortspec=date&amp;submit=Submit&quot;&gt;Jeffrey A. Frost&lt;/a&gt;&lt;a id=&quot;xref-aff-1-8&quot; class=&quot;xref-aff&quot; href=&quot;#aff-1&quot;&gt;1&lt;/a&gt;, and   &lt;a class=&quot;name-search&quot; href=&quot;/search?author1=Seth+J.+Corey&amp;sortspec=date&amp;submit=Submit&quot;&gt;Seth J. Corey&lt;/a&gt;&lt;a id=&quot;xref-aff-1-9&quot; class=&quot;xref-aff&quot; href=&quot;#aff-1&quot;&gt;3&lt;/a&gt;   &lt;a id=&quot;aff-1&quot; name=&quot;aff-1&quot;&gt;&lt;/a&gt;&lt;address&gt;&lt;strong&gt;Authors&#39; Affiliations:&lt;/strong&gt;1Integrative Biology and Pharmacology, University of Texas Health Science Center; 2Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas and 3Departments of Pediatrics and Cellular and Molecular Biology, Children&#39;s Memorial Hospital and the Robert H. Lurie Comprehensive Cancer Center and 4Department of Medicine and Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois     &lt;strong&gt;Corresponding Author:&lt;/strong&gt;&lt;br /&gt; Seth J. Corey, Robert H. Lurie Comprehensive Cancer Center, 303 East Superior Street, Chicago, IL 60611. Phone: 312-503-6694; Fax: 312-503-0189; E-mail: s-corey{at}northwestern.edu.     Abstract In the earliest stages of metastasis, breast cancer cells must reorganize the cytoskeleton to affect cell shape change and promote cell invasion and motility. These events require the cytoskeletal regulators Cdc42 and Rho, their effectors such as N-WASp/WAVE, and direct inducers of actin polymerization such as Arp2/3. Little consideration has been given to molecules that shape the cell membrane. The F-BAR proteins CIP4, TOCA-1, and FBP17 generate membrane curvature and act as scaffolding proteins for activated Cdc42 and N-WASp. We found that expression of CIP4, but not TOCA-1 or FBP17, was increased in invasive breast cancer cell lines in comparison with weakly or noninvasive breast cancer cell lines. Endogenous CIP4 localized to the leading edge of migrating cells and to invadopodia in cells invading gelatin. Because CIP4 serves as a scaffolding protein for Cdc42, Src, and N-WASp, we tested whether loss of CIP4 could result in decreased N-WASp function. Interaction between CIP4 and N-WASp was epidermal growth factor responsive, and CIP4 silencing by small interfering RNA caused decreased tyrosine phosphorylation of N-WASp at a Src-dependent activation site (Y256). CIP4 silencing also impaired the migration and invasion of MDA-MB-231 cells and was associated with decreased formation of invadopodia and gelatin degradation. This study presents a new role for CIP4 in the promotion of migration and invasion of MDA-MB-231 breast cancer cells and establishes the contribution of F-BAR proteins to cancer cell motility and invasion. Cancer Res; 70(21); 8347–56. ©2010 AACR. &lt;/p&gt;   Footnotes   &lt;strong&gt;Note:&lt;/strong&gt; Supplementary data for this article are available at Cancer Research Online (&lt;a href=&quot;http://cancerres.aacrjournals.org/&quot;&gt;http://cancerres.aacrjournals.org/&lt;/a&gt;). &lt;/p&gt;     Received November 13, 2009.  Revision received July 12, 2010.  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title=&quot;Table of Contents&quot;&gt;Table of Contents&lt;/a&gt;     This Article         Published OnlineFirst  October 12, 2010; doi: 10.1158/0008-5472.CAN-09-4149     &lt;abbr title=&quot;Cancer Research&quot; class=&quot;slug-jnl-abbrev&quot;&gt; Cancer Res November 1, 2010    70;   8347             » Abstract &lt;a href=&quot;/content/70/21/8347.full&quot; rel=&quot;view-full-text&quot;&gt;Full Text&lt;/a&gt; &lt;a href=&quot;/content/70/21/8347.full.pdf+html&quot; rel=&quot;view-full-text.pdf&quot;&gt;Full Text (PDF)&lt;/a&gt; &lt;a href=&quot;/content/70/21/8347/suppl/DC1&quot; rel=&quot;supplemental-data&quot; class=&quot;dslink-supplementary-data&quot;&gt;Supplementary Data&lt;/a&gt;  All Versions of this Article: &lt;a href=&quot;/content/early/2010/10/07/0008-5472.CAN-09-4149&quot;&gt;0008-5472.CAN-09-4149v1&lt;/a&gt; 70/21/8347 most recent       Classifications    &lt;a class=&quot;tocsection-search&quot; href=&quot;/search?tocsectionid=Microenvironment+and+Immunology&amp;sortspec=date&amp;submit=Submit&quot;&gt;Microenvironment and Immunology&lt;/a&gt; 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target=&quot;_blank&quot; rel=&quot;nofollow&quot;&gt;View the original article here&lt;/a&gt;&lt;/p&gt;</content><link rel='replies' type='application/atom+xml' href='http://nmdbreastcancerawareness.blogspot.com/feeds/4880531623139948959/comments/default' title='Post Comments'/><link rel='replies' type='text/html' href='http://nmdbreastcancerawareness.blogspot.com/2010/11/cdc42-interacting-protein-4-promotes.html#comment-form' title='0 Comments'/><link rel='edit' type='application/atom+xml' href='http://www.blogger.com/feeds/763914643556275777/posts/default/4880531623139948959'/><link rel='self' type='application/atom+xml' href='http://www.blogger.com/feeds/763914643556275777/posts/default/4880531623139948959'/><link rel='alternate' type='text/html' href='http://nmdbreastcancerawareness.blogspot.com/2010/11/cdc42-interacting-protein-4-promotes.html' title='Cdc42-Interacting Protein 4 Promotes Breast Cancer Cell Invasion and Formation of Invadopodia through Activation of N-WASp'/><author><name>Anonymous</name><uri>http://www.blogger.com/profile/14799558047407972898</uri><email>noreply@blogger.com</email><gd:image rel='http://schemas.google.com/g/2005#thumbnail' width='16' height='16' src='https://img1.blogblog.com/img/b16-rounded.gif'/></author><thr:total>0</thr:total></entry><entry><id>tag:blogger.com,1999:blog-763914643556275777.post-5998896131998331285</id><published>2010-11-09T04:55:00.000-08:00</published><updated>2010-11-09T04:55:00.043-08:00</updated><category scheme="http://www.blogger.com/atom/ns#" term="ACRIN"/><category scheme="http://www.blogger.com/atom/ns#" term="Breast"/><category scheme="http://www.blogger.com/atom/ns#" term="community"/><category scheme="http://www.blogger.com/atom/ns#" term="EUSOBI"/><category scheme="http://www.blogger.com/atom/ns#" term="exams"/><category scheme="http://www.blogger.com/atom/ns#" term="facilities"/><category scheme="http://www.blogger.com/atom/ns#" term="Majority"/><category scheme="http://www.blogger.com/atom/ns#" term="performing"/><category scheme="http://www.blogger.com/atom/ns#" term="requirements"/><category scheme="http://www.blogger.com/atom/ns#" term="technical"/><title type='text'>Majority of community facilities performing breast MRI exams meet ACRIN and EUSOBI technical requirements</title><content type='html'> &lt;A onclick=&quot;window.opener.focus();return false;&quot; href=&quot;http://www.eurekalert.org/pubnews.php&quot;&gt;&lt;IMG border=0 alt=&quot;[ Back to EurekAlert! ]&quot; align=right src=&quot;/back2e.gif&quot; width=140 height=36&gt;&lt;/A&gt; &lt;STRONG class=relemb&gt;Public release date: 1-Nov-2010&lt;/STRONG&gt;&lt;BR&gt;[ | &lt;A onclick=&quot;visit(&#39;http://www.eurekalert.org/emailrelease.php?file=acor-moc102910.php&#39;)&quot; href=&quot;about:blank#&quot; target=_self&gt;E-mail&lt;/A&gt; | &lt;A onmouseover=&quot;return addthis_open(this, &#39;&#39;, &#39;[URL]&#39;, &#39;[TITLE]&#39;)&quot; onmouseout=addthis_close() onclick=&quot;return addthis_sendto()&quot; href=&quot;http://www.addthis.com/bookmark.php?v=20&quot;&gt;&lt;IMG border=0 alt=Share src=&quot;/shareicon.gif&quot; width=11 height=11&gt; Share&lt;/A&gt; ] &lt;P&gt;Contact: Heather Curry&lt;BR&gt;&lt;A href=&quot;mailto:hcurry@acr.org&quot;&gt;hcurry@acr.org&lt;/A&gt;&lt;BR&gt;703-390-9822&lt;BR&gt;&lt;A href=&quot;http://www.arrs.org/&quot;&gt;American College of Radiology / American Roentgen Ray Society&lt;/A&gt; &lt;BR&gt;&lt;P&gt;An overwhelming majority of Breast Cancer Surveillance Consortium (BCSC) facilities performing breast magnetic resonance imaging (MRI) in the U.S. are up-to-par with American College of Radiology Imaging Network (ACRIN) and European Society of Breast Imaging (EUSOBI) technical standards and requirements, according to a study in the November issue of the Journal of the American College of Radiology (&lt;A href=&quot;http://www.jacr.org/&quot;&gt;www.jacr.org&lt;/A&gt;). The BCSC is a collaborative effort to improve breast cancer research. It consists of five mammography registries and two affiliated sites with linkages to pathology and/or tumor registries. &lt;/P&gt;&lt;P&gt;As its use has expanded, breast MRI has been adopted by community practice facilities, where most women undergo breast imaging in the U.S. However, little is known about the technical quality of MRI performed at these facilities. &lt;/P&gt;&lt;P&gt;&quot;The purpose of our study was to evaluate breast MRI equipment and acquisition techniques currently used among a variety of community practice facilities across the U.S., using data from the BCSC, and to determine the compliance with current minimum standards specified by the ACRIN Trial 6667 and the EUSOBI,&quot; said Wendy B. DeMartini, MD, lead author of the study.&lt;/P&gt;&lt;P&gt;BCSC facilities performing breast MRI were identified and queried by survey regarding breast MRI equipment and technical parameters. Results tallied and percentages of facilities meeting ACRIN and EUSOBI standards were calculated. From 23 facilities performing breast MRI, results were obtained from 14 facilities. &quot;Adherence to minimum standards for breast MRI equipment across community practice facilities was excellent. Compliance with equipment recommendations of 1.5T field strength MRI scanners was 94 percent and all scanners employed a dedicated breast coil, as recommended by both ACRIN and the EUSOBI,&quot; said DeMartini. &lt;/P&gt;&lt;P&gt;&quot;Breast MRI is highly sensitive, but is a complex tool for which appropriate use requires optimization of multiple technical parameters which can be a tedious process. However, we found that nearly all facilities surveyed in the U.S. met ACRIN and EUSOBI standards for breast MRI equipment,&quot; said DeMartini. &lt;/P&gt;&lt;P&gt;The November issue of JACR is an important resource for radiology and nuclear medicine professionals as well as students seeking clinical and educational improvement.&lt;/P&gt;&lt;P&gt;For more information about JACR, please visit &lt;A href=&quot;http://www.jacr.org/&quot;&gt;www.jacr.org&lt;/A&gt;.&lt;/P&gt;&lt;P&gt;To receive an electronic copy of an article appearing in JACR or to set up an interview with a JACR author or another ACR member, please contact Heather Curry at 703-390-9822 or &lt;A href=&quot;mailto:hcurry@acr.org&quot;&gt;hcurry@acr.org&lt;/A&gt;.&lt;/P&gt;&lt;A onclick=&quot;window.opener.focus();return false;&quot; href=&quot;http://www.eurekalert.org/pubnews.php&quot;&gt;&lt;IMG border=0 alt=&quot;[ Back to EurekAlert! ]&quot; align=right src=&quot;/back2e.gif&quot; width=140 height=36&gt;&lt;/A&gt; [ | &lt;A onclick=&quot;visit(&#39;http://www.eurekalert.org/emailrelease.php?file=acor-moc102910.php&#39;)&quot; href=&quot;about:blank#&quot; target=_self&gt;E-mail&lt;/A&gt; | &lt;A onmouseover=&quot;return addthis_open(this, &#39;&#39;, &#39;[URL]&#39;, &#39;[TITLE]&#39;)&quot; onmouseout=addthis_close() onclick=&quot;return addthis_sendto()&quot; href=&quot;http://www.addthis.com/bookmark.php?v=20&quot;&gt;&lt;IMG border=0 alt=Share src=&quot;/shareicon.gif&quot; width=11 height=11&gt; Share&lt;/A&gt; ] &lt;br /&gt;&lt;p&gt;&lt;a href=&quot;http://www.medworm.com/index.php?rid=4122776&amp;cid=c_2_46_f&amp;fid=31011&amp;url=http%3A%2F%2Fwww.eurekalert.org%2Fpub_releases%2F2010-11%2Facor-moc102910.php&quot; target=&quot;_blank&quot; rel=&quot;nofollow&quot;&gt;View the original article here&lt;/a&gt;&lt;/p&gt;</content><link rel='replies' type='application/atom+xml' href='http://nmdbreastcancerawareness.blogspot.com/feeds/5998896131998331285/comments/default' title='Post Comments'/><link rel='replies' type='text/html' href='http://nmdbreastcancerawareness.blogspot.com/2010/11/majority-of-community-facilities.html#comment-form' title='0 Comments'/><link rel='edit' type='application/atom+xml' href='http://www.blogger.com/feeds/763914643556275777/posts/default/5998896131998331285'/><link rel='self' type='application/atom+xml' href='http://www.blogger.com/feeds/763914643556275777/posts/default/5998896131998331285'/><link rel='alternate' type='text/html' href='http://nmdbreastcancerawareness.blogspot.com/2010/11/majority-of-community-facilities.html' title='Majority of community facilities performing breast MRI exams meet ACRIN and EUSOBI technical requirements'/><author><name>Anonymous</name><uri>http://www.blogger.com/profile/14799558047407972898</uri><email>noreply@blogger.com</email><gd:image rel='http://schemas.google.com/g/2005#thumbnail' width='16' height='16' src='https://img1.blogblog.com/img/b16-rounded.gif'/></author><thr:total>0</thr:total></entry><entry><id>tag:blogger.com,1999:blog-763914643556275777.post-6803065100476884151</id><published>2010-11-08T20:52:00.000-08:00</published><updated>2010-11-08T20:52:00.412-08:00</updated><category scheme="http://www.blogger.com/atom/ns#" term="Breast"/><category scheme="http://www.blogger.com/atom/ns#" term="Cancer"/><category scheme="http://www.blogger.com/atom/ns#" term="CyberKnife"/><category scheme="http://www.blogger.com/atom/ns#" term="EarlyStage"/><category scheme="http://www.blogger.com/atom/ns#" term="Radiosurgery"/><title type='text'>CyberKnife Radiosurgery for Early-Stage Breast Cancer</title><content type='html'> &lt;BODY readability=&quot;0&quot;&gt;&lt;P&gt;SUNNYVALE, Calif., Oct. 31 -- (Healthcare Sales &amp; Marketing Network) -- Accuray Incorporated, (Nasdaq: ARAY), a global leader in the field of radiosurgery, announced today studies underway at two leading academic institutions using CyberKnife radiosurgery in breast cancer treatment. These two studies, from the University of Texas Southwestern and Fox Chase Cancer Center, will be presented at the 52nd Annual Meeting of the American Society for Radiation Oncology (ASTRO) in San Diego from October 31 to November 4.&lt;/P&gt;According to the American Cancer Society, breast cancer is the most frequently diagnosed cancer among women and the second leading cause of cancer death. Typically, women with early stage, localized breast cancer are treated with a lumpectomy, also known as breast conserving surgery, followed by radiation to ensure any remaining microscopic cancer cells are treated. It has been shown that women receiving radiation following surgery have more than a 15 percent reduction in recurrence rates as compared to women who did not receive radiation after their tumors were surgically removed(1). &lt;P&gt;Initially clinicians delivered radiation to the whole breast following surgery, but over the last decade a more limited radiation approach has gained interest among clinicians and patients. This approach, called partial breast irradiation, can be as effective as whole breast irradiation and is less likely to damage to the heart, lungs, and skin, leading to improved cosmetic outcomes and reduced toxicities.(2)&lt;/P&gt;&lt;P&gt;Partial breast irradiation can be delivered in a number of ways, including invasive options, such as MammoSite, which involves surgical implantation of a catheter in the breast to deliver interstitial brachytherapy, or non-invasive radiation therapy options such as 3D conformal or intensity modulated radiation therapy (IMRT).&lt;/P&gt;&lt;P&gt;Each technique has its advantages and drawbacks: For example, invasive brachytherapy can cause infection, hematoma or abscess(3-4). While non-invasive radiation therapy approaches minimize such risks, studies have demonstrated that the larger margins required to compensate for treatment inaccuracies, such as those caused by the movement of the breast with respiration, result in a higher risk for overdosing the skin and nearby critical structures such as the heart and lungs(5-7). One recent study investigating IMRT for partial breast irradiation found 7 out of 32 evaluated patients developed unacceptable cosmesis, leading to premature closure of the study(5).&lt;/P&gt;&lt;P&gt;Because of the non-invasive delivery and high precision that the CyberKnife System offers in treating tumors throughout the body, clinicians see a role for it in breast cancer treatment. The CyberKnife System has the unique ability to not only track tumor movement during respiration, but to also lock onto the tumor as it moves delivering radiation directly to the tumor and avoiding damage to surrounding critical structures. The CyberKnife System&#39;s extreme precision enables clinicians to reduce the treatment margins that are often added with conventional IMRT Systems. For this reason, clinicians believe partial breast irradiation using the CyberKnife System holds the potential to improve toxicity and associated side effects for patients.&lt;/P&gt;&lt;P&gt;&quot;We think that the real-time tracking and high conformality made possible with the CyberKnife System could result in reduced toxicity by reducing the dose to the surrounding breast tissue, skin, chest wall, lung or heart,&quot; said Charlie Ma, Ph.D., Professor and Vice-Chairman, Department of Radiation Oncology, Fox Chase Cancer Center.&lt;/P&gt;&lt;P&gt;University of Texas Southwestern recently launched a multi-center early stage breast cancer protocol, which is currently accruing patients. UTSW was one of the first five CyberKnife sites in the world and has remained on the forefront of clinical research.&lt;/P&gt;&lt;P&gt;Physicians at UTSW intend to demonstrate equivalent local control rates or to improve those seen in current treatment for early-stage disease while attempting to increase convenience, limit invasiveness, decrease toxicity and improve cosmesis compared to other methods of radiation treatment. The treatment regimen using the CyberKnife System would be five days compared to 25-30 days typically associated with conventional radiation therapy.&lt;/P&gt;&lt;P&gt;&quot;In particular, we believe a very abbreviated, non-invasive, outpatient treatment would be considered a favorable option to underserved populations of women living in more remote areas for whom longer courses of treatment pose a barrier,&quot; said Robert Timmerman, M.D., professor of Radiation Oncology at UTSW and lead author of the ongoing study.&lt;/P&gt;&lt;P&gt;(1). Fisher B, Anderson S, Bryant J, Margolese R, Deutsch M, Fisher E, Jeong J-H, Wolmark N. Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer. New England Journal of Medicine 2002; 347:1233-1241.&lt;/P&gt;&lt;P&gt;(2). Wadasadawala T, Sarin R, Budrukker A et al. Accelerated partial-breast irradiation vs conventional whole-breast radiotherapy in early breast cancer: A case-control study of disease control, cosmesis, and complications. Journal of Cancer Research &amp; Therapy 2009: 5:2 93-101.&lt;/P&gt;&lt;P&gt;(3). Watkins JM, Harper JL, Dragun AE, Ashenafi MS, Sinha D, Li J, Cole DJ, Jenrette JM 3rd. Incidence and prognostic factors for seroma development after MammoSite breast brachytherapy. Brachytherapy. 2008;7:305-9.&lt;/P&gt;&lt;P&gt;(4). Evans SB, Kaufman SA, Price LL, Cardarelli G, Dipetrillo TA, Wazer DE. Persistent seroma after intraoperative placement of MammoSite for accelerated partial breast irradiation: incidence, pathologic anatomy, and contributing factors. Int J Radiat Oncol Biol Phys. 2006;65:333-9.&lt;/P&gt;&lt;P&gt;(5). Jagsi R, Ben-David MA, Moran JM, Marsh RB, Griffith KA, Hayman JA, Pierce LJ. Unacceptable cosmesis in a protocol investigating intensity-modulated radiotherapy with active breathing control for accelerated partial-breast irradiation. Int J Radiat Oncol Biol Phys. 2010;76:71-8.&lt;/P&gt;&lt;P&gt;(6). Vicini FA, Chen P, Wallace M, Mitchell C, Hasan Y, Grills I, Kestin L, Schell S, Goldstein NS, Kunzman J, Gilbert S, Martinez A. Interim cosmetic results and toxicity using 3D conformal external beam radiotherapy to deliver accelerated partial breast irradiation in patients with early-stage breast cancer treated with breast-conserving therapy. Int J Radiat Oncol Biol Phys. 2007;69:1124-30.&lt;/P&gt;&lt;P&gt;(7). Livi L, Buonamici FB, Simontacchi G, Scotti V, Fambrini M, Compagnucci A, Paiar F, Scoccianti S, Pallotta S, Detti B, Agresti B, Talamonti C, Mangoni M, Bianchi S, Cataliotti L, Marrazzo L, Bucciolini M, Biti G. Accelerated partial breast irradiation with IMRT: new technical approach and interim analysis of acute toxicity in a phase III randomized clinical trial. Int J Radiat Oncol Biol Phys. 2010;77:509-15.&lt;/P&gt;&lt;P&gt;About the CyberKnife? Robotic Radiosurgery System&lt;/P&gt;&lt;P&gt;The CyberKnife Robotic Radiosurgery System is the world&#39;s only robotic radiosurgery system designed to treat tumors anywhere in the body non-invasively. Using continual image guidance technology and computer controlled robotic mobility, the CyberKnife System automatically tracks, detects and corrects for tumor and patient movement in real-time throughout the treatment. This enables the CyberKnife System to deliver high-dose radiation with pinpoint precision, which minimizes damage to surrounding healthy tissue and eliminates the need for invasive head or body stabilization frames.&lt;/P&gt;&lt;P&gt;About Accuray&lt;/P&gt;&lt;P&gt;Accuray Incorporated (Nasdaq:ARAY ), based in Sunnyvale, Calif., is a global leader in the field of radiosurgery dedicated to providing an improved quality of life and a non-surgical treatment option for those diagnosed with cancer. Accuray develops and markets the CyberKnife Robotic Radiosurgery System, which extends the benefits of radiosurgery to include extracranial tumors, including those in the spine, lung, prostate, liver and pancreas. To date, the CyberKnife System has been used to treat more 100,000 patients worldwide and more than 206 systems have been installed in leading hospitals in the Americas, Europe and Asia. For more information, please visit www.accuray.com. &lt;/P&gt;&lt;P&gt;Safe Harbor Statement&lt;/P&gt;&lt;P&gt;The foregoing may contain certain forward-looking statements that involve risks and uncertainties, including uncertainties associated with the medical device industry. Except for the historical information contained herein, the matters set forth in this press release, including statements relating to clinical evidence and clinical results are forward-looking statements within the meaning of the &quot;safe harbor&quot; provisions of the Private Securities Litigation Reform Act of 1995. Forward-looking statements speak only as of the date the statements are made and are based on information available at the time those statements are made and/or management&#39;s good faith belief as of that time with respect to future events. You should not put undue reliance on any forward-looking statements. Important factors that could cause actual performance and results to differ materially from the forward-looking statements we make include: clinical applications, clinical outcomes, potential results of clinical studies, competing products, the combination of our products with complementary technology; and other risks detailed from time to time under the heading &quot;Risk Factors&quot; in our report on Form 10-K for the 2010 fiscal year which has been filed with the Securities and Exchange Commission, filed on August 31, 2010. The Company&#39;s actual results of operations may differ significantly from those contemplated by such forward-looking statements as a result of these and other factors. We assume no obligation to update forward-looking statements to reflect actual performance or results, changes in assumptions or changes in other factors affecting forward-looking information, except to the extent required by applicable securities laws.&lt;/P&gt;&lt;br /&gt;&lt;p&gt;&lt;a href=&quot;http://www.medworm.com/index.php?rid=4123134&amp;cid=c_2_34_f&amp;fid=35575&amp;url=http%3A%2F%2Fsalesandmarketingnetwork.com%2Fnews_release.php%3FID%3D2032013&quot; target=&quot;_blank&quot; rel=&quot;nofollow&quot;&gt;View the original article here&lt;/a&gt;&lt;/p&gt;</content><link rel='replies' type='application/atom+xml' href='http://nmdbreastcancerawareness.blogspot.com/feeds/6803065100476884151/comments/default' title='Post Comments'/><link rel='replies' type='text/html' href='http://nmdbreastcancerawareness.blogspot.com/2010/11/cyberknife-radiosurgery-for-early-stage.html#comment-form' title='0 Comments'/><link rel='edit' type='application/atom+xml' href='http://www.blogger.com/feeds/763914643556275777/posts/default/6803065100476884151'/><link rel='self' type='application/atom+xml' href='http://www.blogger.com/feeds/763914643556275777/posts/default/6803065100476884151'/><link rel='alternate' type='text/html' href='http://nmdbreastcancerawareness.blogspot.com/2010/11/cyberknife-radiosurgery-for-early-stage.html' title='CyberKnife Radiosurgery for Early-Stage Breast Cancer'/><author><name>Anonymous</name><uri>http://www.blogger.com/profile/14799558047407972898</uri><email>noreply@blogger.com</email><gd:image rel='http://schemas.google.com/g/2005#thumbnail' width='16' height='16' src='https://img1.blogblog.com/img/b16-rounded.gif'/></author><thr:total>0</thr:total></entry><entry><id>tag:blogger.com,1999:blog-763914643556275777.post-2396502200045648858</id><published>2010-11-08T11:43:00.000-08:00</published><updated>2010-11-08T11:43:00.661-08:00</updated><category scheme="http://www.blogger.com/atom/ns#" term="among"/><category scheme="http://www.blogger.com/atom/ns#" term="Before"/><category scheme="http://www.blogger.com/atom/ns#" term="Breast"/><category scheme="http://www.blogger.com/atom/ns#" term="Cancer"/><category scheme="http://www.blogger.com/atom/ns#" term="Detection"/><category scheme="http://www.blogger.com/atom/ns#" term="Diagnosis"/><category scheme="http://www.blogger.com/atom/ns#" term="Elevated"/><category scheme="http://www.blogger.com/atom/ns#" term="Epidermal"/><category scheme="http://www.blogger.com/atom/ns#" term="Factor"/><category scheme="http://www.blogger.com/atom/ns#" term="Growth"/><category scheme="http://www.blogger.com/atom/ns#" term="hormone"/><category scheme="http://www.blogger.com/atom/ns#" term="Levels"/><category scheme="http://www.blogger.com/atom/ns#" term="Plasma"/><category scheme="http://www.blogger.com/atom/ns#" term="Receptor"/><category scheme="http://www.blogger.com/atom/ns#" term="therapy"/><category scheme="http://www.blogger.com/atom/ns#" term="Users"/><title type='text'>Detection of Elevated Plasma Levels of Epidermal Growth Factor Receptor Before Breast Cancer Diagnosis among Hormone Therapy Users</title><content type='html'>    Detection of Elevated Plasma Levels of Epidermal Growth Factor Receptor Before Breast Cancer Diagnosis among Hormone Therapy Users — Cancer Res                                                      &lt;body&gt; 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href=&quot;/search?author1=Sharon+J.+Pitteri&amp;sortspec=date&amp;submit=Submit&quot;&gt;Sharon J. Pitteri&lt;/a&gt;,   &lt;a class=&quot;name-search&quot; href=&quot;/search?author1=Lynn+M.+Amon&amp;sortspec=date&amp;submit=Submit&quot;&gt;Lynn M. Amon&lt;/a&gt;,   &lt;a class=&quot;name-search&quot; href=&quot;/search?author1=Tina+Busald+Buson&amp;sortspec=date&amp;submit=Submit&quot;&gt;Tina Busald Buson&lt;/a&gt;,   &lt;a class=&quot;name-search&quot; href=&quot;/search?author1=Yuzheng+Zhang&amp;sortspec=date&amp;submit=Submit&quot;&gt;Yuzheng Zhang&lt;/a&gt;,   &lt;a class=&quot;name-search&quot; href=&quot;/search?author1=Melissa+M.+Johnson&amp;sortspec=date&amp;submit=Submit&quot;&gt;Melissa M. Johnson&lt;/a&gt;,   &lt;a class=&quot;name-search&quot; href=&quot;/search?author1=Alice+Chin&amp;sortspec=date&amp;submit=Submit&quot;&gt;Alice Chin&lt;/a&gt;,   &lt;a class=&quot;name-search&quot; href=&quot;/search?author1=Jacob+Kennedy&amp;sortspec=date&amp;submit=Submit&quot;&gt;Jacob Kennedy&lt;/a&gt;,   &lt;a class=&quot;name-search&quot; href=&quot;/search?author1=Chee-Hong+Wong&amp;sortspec=date&amp;submit=Submit&quot;&gt;Chee-Hong Wong&lt;/a&gt;,   &lt;a class=&quot;name-search&quot; href=&quot;/search?author1=Qing+Zhang&amp;sortspec=date&amp;submit=Submit&quot;&gt;Qing Zhang&lt;/a&gt;,   &lt;a class=&quot;name-search&quot; href=&quot;/search?author1=Hong+Wang&amp;sortspec=date&amp;submit=Submit&quot;&gt;Hong Wang&lt;/a&gt;,   &lt;a class=&quot;name-search&quot; href=&quot;/search?author1=Paul+D.+Lampe&amp;sortspec=date&amp;submit=Submit&quot;&gt;Paul D. Lampe&lt;/a&gt;,   &lt;a class=&quot;name-search&quot; href=&quot;/search?author1=Ross+L.+Prentice&amp;sortspec=date&amp;submit=Submit&quot;&gt;Ross L. Prentice&lt;/a&gt;,   &lt;a class=&quot;name-search&quot; href=&quot;/search?author1=Martin+W.+McIntosh&amp;sortspec=date&amp;submit=Submit&quot;&gt;Martin W. McIntosh&lt;/a&gt;,   &lt;a class=&quot;name-search&quot; href=&quot;/search?author1=Samir+M.+Hanash&amp;sortspec=date&amp;submit=Submit&quot;&gt;Samir M. Hanash&lt;/a&gt;, and   &lt;a class=&quot;name-search&quot; href=&quot;/search?author1=Christopher+I.+Li&amp;sortspec=date&amp;submit=Submit&quot;&gt;Christopher I. Li&lt;/a&gt;   &lt;a id=&quot;aff-1&quot; name=&quot;aff-1&quot;&gt;&lt;/a&gt;&lt;address&gt;&lt;strong&gt;Authors&#39; Affiliation:&lt;/strong&gt; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington     &lt;strong&gt;Corresponding Author:&lt;/strong&gt;&lt;br /&gt; Christopher I. Li, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, M4-C308, P.O. Box 19024, Seattle, WA 98109-1024. Phone: 206-667-7444; Fax: 206-667-5948; E-mail: cili{at}fhcrc.org.     Abstract Applying advanced proteomic technologies to prospectively collected specimens from large studies is one means of identifying preclinical changes in plasma proteins that are potentially relevant to the early detection of diseases such as breast cancer. We conducted 14 independent quantitative proteomics experiments comparing pooled plasma samples collected from 420 estrogen receptor–positive (ER+) breast cancer patients =17 months before their diagnosis and matched controls. Based on the more than 3.4 million tandem mass spectra collected in the discovery set, 503 proteins were quantified, of which 57 differentiated cases from controls with a P&lt;/em&gt; value of &lt;0.1. Seven of these proteins, for which quantitative ELISA assays were available, were assessed in an independent validation set. Of these candidates, epidermal growth factor receptor (EGFR) was validated as a predictor of breast cancer risk in an independent set of preclinical plasma samples for women overall [odds ratio (OR), 1.44; P&lt;/em&gt; = 0.0008] and particularly for current users of estrogen plus progestin (E + P) menopausal hormone therapy (OR, 2.49; P&lt;/em&gt; = 0.0001). Among current E + P users, the EGFR sensitivity for breast cancer risk was 31% with 90% specificity. Whereas the sensitivity and specificity of EGFR are insufficient for a clinically useful early detection biomarker, this study suggests that proteins that are elevated preclinically in women who go on to develop breast cancer can be discovered and validated using current proteomic technologies. Further studies are warranted to examine the role of EGFR and to discover and validate other proteins that could potentially be used for early detection of breast cancer. Cancer Res; 70(21); 8598–606. ©2010 AACR. &lt;/p&gt;   Footnotes   &lt;strong&gt;Note:&lt;/strong&gt; Supplementary data for this article are available at Cancer Research Online (&lt;a href=&quot;http://cancerres.aacrjournals.org/&quot;&gt;http://cancerres.aacrjournals.org/&lt;/a&gt;). &lt;/p&gt;     Received May 11, 2010.  Revision received July 25, 2010.  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Schneider&lt;/a&gt;&lt;a id=&quot;xref-aff-1-10&quot; class=&quot;xref-aff&quot; href=&quot;#aff-1&quot;&gt;2&lt;/a&gt;,   &lt;a class=&quot;name-search&quot; href=&quot;/search?author1=Luiz+Fernando+Lima+Reiz&amp;sortspec=date&amp;submit=Submit&quot;&gt;Luiz Fernando Lima Reiz&lt;/a&gt;&lt;a id=&quot;xref-aff-1-11&quot; class=&quot;xref-aff&quot; href=&quot;#aff-1&quot;&gt;7&lt;/a&gt;,   &lt;a class=&quot;name-search&quot; href=&quot;/search?author1=Fernando+Augusto+Soares&amp;sortspec=date&amp;submit=Submit&quot;&gt;Fernando Augusto Soares&lt;/a&gt;&lt;a id=&quot;xref-aff-1-12&quot; class=&quot;xref-aff&quot; href=&quot;#aff-1&quot;&gt;8&lt;/a&gt;,   &lt;a class=&quot;name-search&quot; href=&quot;/search?author1=Susan+K.+Logan&amp;sortspec=date&amp;submit=Submit&quot;&gt;Susan K. Logan&lt;/a&gt;&lt;a id=&quot;xref-aff-1-13&quot; class=&quot;xref-aff&quot; href=&quot;#aff-1&quot;&gt;1&lt;/a&gt;,&lt;a id=&quot;xref-aff-1-14&quot; class=&quot;xref-aff&quot; href=&quot;#aff-1&quot;&gt;4&lt;/a&gt;, and   &lt;a class=&quot;name-search&quot; href=&quot;/search?author1=Michael+J.+Garabedian&amp;sortspec=date&amp;submit=Submit&quot;&gt;Michael J. Garabedian&lt;/a&gt;&lt;a id=&quot;xref-aff-1-15&quot; class=&quot;xref-aff&quot; href=&quot;#aff-1&quot;&gt;2&lt;/a&gt;,&lt;a id=&quot;xref-aff-1-16&quot; class=&quot;xref-aff&quot; href=&quot;#aff-1&quot;&gt;4&lt;/a&gt;   &lt;a id=&quot;aff-1&quot; name=&quot;aff-1&quot;&gt;&lt;/a&gt;&lt;address&gt;&lt;strong&gt;Authors&#39; Affiliations:&lt;/strong&gt; Departments of 1Pharmacology, 2Microbiology, 3Environmental Medicine, and 4Urology, and NYU Cancer Institute, NYU School of Medicine, and 5Department of Medicine, New York Hospital Queens and Weill Cornell Medical College, New York, New York; 6Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut; 7Instituto de ensino e pesquisa, Hospital Sirio Libanes, and 8Department of Anatomic Pathology, Hospital AC Camargo, Sao Paulo, SP, Brazil     &lt;strong&gt;Corresponding Author:&lt;/strong&gt;&lt;br /&gt; Michael J. Garabedian, Department of Microbiology, NYU School of Medicine, 550 First Avenue, New York, NY 10016. Phone: 212-263-7662; Fax: 212-263-8276; E-mail: michael.garabedian{at}nyumc.org.     Abstract p23 is a heat shock protein 90 (Hsp90) cochaperone located in both the cytoplasm and nucleus that stabilizes unliganded steroid receptors, controls the catalytic activity of certain kinases, regulates protein-DNA dynamics, and is upregulated in several cancers. We had previously shown that p23-overexpressing MCF-7 cells (MCF-7+p23) exhibit increased invasion without affecting the estrogen-dependent proliferative response, which suggests that p23 differentially regulates genes controlling processes linked to breast tumor metastasis. To gain a comprehensive view of the effects of p23 on estrogen receptor (ER)-dependent and -independent gene expression, we profiled mRNA expression from control versus MCF-7+p23 cells in the absence and presence of estrogen. A number of p23-sensitive target genes involved in metastasis and drug resistance were identified. Most striking is that many of these genes are also misregulated in invasive breast cancers, including PMP22, ABCC3, AGR2, Sox3, TM4SF1&lt;/em&gt;, and p8&lt;/em&gt; (NUPR1&lt;/em&gt;). Upregulation of the ATP-dependent transporter ABCC3 by p23 conferred resistance to the chemotherapeutic agents etoposide and doxorubicin in MCF-7+p23 cells. MCF-7+p23 cells also displayed higher levels of activated Akt and an expanded phosphoproteome relative to control cells, suggesting that elevated p23 also enhances cytoplasmic signaling pathways. For breast cancer patients, tumor stage together with high cytoplasmic p23 expression more accurately predicted disease recurrence and mortality than did stage alone. High nuclear p23 was found to be associated with high cytoplasmic p23, therefore both may promote tumor progression and poor prognosis by increasing metastatic potential and drug resistance in breast cancer patients. Cancer Res; 70(21); 8446–56. ©2010 AACR. &lt;/p&gt;   Footnotes   &lt;strong&gt;Note:&lt;/strong&gt; Supplementary data for this article are available at Cancer Research Online (&lt;a href=&quot;http://cancerres.aacrjournals.org/&quot;&gt;http://cancerres.aacrjournals.org/&lt;/a&gt;). &lt;/p&gt;     Received May 3, 2010.  Revision received August 12, 2010.  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title=&quot;Table of Contents&quot;&gt;Table of Contents&lt;/a&gt;     This Article         Published OnlineFirst  September 16, 2010; doi: 10.1158/0008-5472.CAN-10-1590     &lt;abbr title=&quot;Cancer Research&quot; class=&quot;slug-jnl-abbrev&quot;&gt; Cancer Res November 1, 2010    70;   8446             » Abstract &lt;a href=&quot;/content/70/21/8446.full&quot; rel=&quot;view-full-text&quot;&gt;Full Text&lt;/a&gt; &lt;a href=&quot;/content/70/21/8446.full.pdf+html&quot; rel=&quot;view-full-text.pdf&quot;&gt;Full Text (PDF)&lt;/a&gt; &lt;a href=&quot;/content/70/21/8446/suppl/DC1&quot; rel=&quot;supplemental-data&quot; class=&quot;dslink-supplementary-data&quot;&gt;Supplementary Data&lt;/a&gt;  All Versions of this Article: &lt;a href=&quot;/content/early/2010/09/16/0008-5472.CAN-10-1590&quot;&gt;0008-5472.CAN-10-1590v1&lt;/a&gt; &lt;a href=&quot;/content/early/2010/10/15/0008-5472.CAN-10-1590&quot;&gt;0008-5472.CAN-10-1590v2&lt;/a&gt; 70/21/8446 most recent       Classifications    &lt;a class=&quot;tocsection-search&quot; 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Hortobagyi&lt;/a&gt;&lt;a id=&quot;xref-aff-1-13&quot; class=&quot;xref-aff&quot; href=&quot;#aff-1&quot;&gt;4&lt;/a&gt;,   &lt;a class=&quot;name-search&quot; href=&quot;/search?author1=W.+Fraser+Symmans&amp;sortspec=date&amp;submit=Submit&quot;&gt;W. Fraser Symmans&lt;/a&gt;&lt;a id=&quot;xref-aff-1-14&quot; class=&quot;xref-aff&quot; href=&quot;#aff-1&quot;&gt;5&lt;/a&gt;,   &lt;a class=&quot;name-search&quot; href=&quot;/search?author1=Luca+Gianni&amp;sortspec=date&amp;submit=Submit&quot;&gt;Luca Gianni&lt;/a&gt;&lt;a id=&quot;xref-aff-1-15&quot; class=&quot;xref-aff&quot; href=&quot;#aff-1&quot;&gt;1&lt;/a&gt;, and   &lt;a class=&quot;name-search&quot; href=&quot;/search?author1=Lajos+Pusztai&amp;sortspec=date&amp;submit=Submit&quot;&gt;Lajos Pusztai&lt;/a&gt;&lt;a id=&quot;xref-aff-1-16&quot; class=&quot;xref-aff&quot; href=&quot;#aff-1&quot;&gt;4&lt;/a&gt;   &lt;a id=&quot;aff-1&quot; name=&quot;aff-1&quot;&gt;&lt;/a&gt;&lt;address&gt;&lt;strong&gt;Authors&#39; Affiliations:&lt;/strong&gt;1Division of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy; 2Department of Gastroenterological Surgery and Surgical Oncology, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan; Departments of 3Bioinformatics, 4Breast Medical Oncology, and 5Pathology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas; 6Department of Gynecology and Obstetrics, University Pierre et Marie Curie Tenon Hospital, Paris, France; and 7Translational Research Unit, Department of Medical Oncology, Hospital of Prato and Istituto Toscana Tumori, Prato, Italy     &lt;strong&gt;Corresponding Author:&lt;/strong&gt;&lt;br /&gt; Lajos Pusztai, Department of Breast Medical Oncology, Unit 1354, The University of Texas M.D. Anderson Cancer Center, P.O. Box 301439, Houston, TX 77230-1439. Phone: 713-792-2817; Fax: 713-794-4385; E-mail: lpusztai{at}mdanderson.org.     Abstract Different kinases are expressed in different clinical subsets of breast cancer. In this study, we assessed kinase expression patterns in different clinical subtypes of breast cancer, evaluated the prognostic and predictive values of kinase metagenes, and investigated their functions in vitro&lt;/em&gt;. Four hundred twenty-eight protein kinases in gene expression data were examined from 684 cases of breast cancer and 51 breast cancer cell lines to identify kinase expression patterns. We tested the prognostic value of kinase metagenes in 684 node-negative patients who received no adjuvant therapy and the predictive value in 233 patients who received uniform neoadjuvant chemotherapy. Twelve kinases were overexpressed in estrogen receptor (ER)–positive/human epidermal growth factor receptor 2 (HER2)–negative, 7 in HER2+, and 28 in ER-/HER2- cancers, respectively. We examined the functional role of 22 kinases overexpressed in ER-/HER2- cancers using siRNA. Downregulation of these kinases caused significant subtype-specific inhibition of cell growth in vitro&lt;/em&gt;. Two robust kinase clusters, including an immune kinase cluster and a mitosis kinase cluster, were present in all clinical subgroups. High mitosis kinase score was associated with worse prognosis but higher pathologic complete response (pCR) in ER+/HER2- cancers, but not in ER-/HER2- or HER2+ cancers, in univariate and multivariate analyses including other genomic predictors (MammaPrint, genomic grade index, and the 76-gene signature). Conversely, higher immune kinase score was associated with better survival in ER+/HER2- and HER2+ tumors and also predicted higher probability of pCR in HER2+ cancers. Taken together, our results indicate that kinases regulating mitosis and immune functions convey distinct prognostic information that varies by clinical subtype. Cancer Res; 70(21); 8852–62. ©2010 AACR. &lt;/p&gt;   Footnotes   &lt;strong&gt;Note:&lt;/strong&gt; Supplementary data for this article are available at Cancer Research Online (&lt;a href=&quot;http://cancerres.aacrjournals.org/&quot;&gt;http://cancerres.aacrjournals.org/&lt;/a&gt;). &lt;/p&gt;     Received March 26, 2010.  Revision received August 4, 2010.  Accepted August 5, 2010.    ©2010 American Association for Cancer Research.      &lt;a href=&quot;/external-ref?tag_url=http://cancerres.aacrjournals.org/cgi/content/long/70/21/8852&amp;title=Prognostic%20and%20Therapeutic%20Implications%20of%20Distinct%20Kinase%20Expression%20Patterns%20in%20Different%20Subtypes%20of%20Breast%20Cancer+--+Bianchini%20et%20al.%2070%20%2821%29%3A%208852+--+&amp;doi=10.1158/0008-5472.CAN-10-1039&amp;link_type=CITEULIKE&quot;&gt;&lt;img src=&quot;C:\Program Files\ABS\Auto Blog Samurai\data\Breast Cancer Awareness\Medworm\citeulike.gif&quot; alt=&quot;Add to CiteULike&quot; title=&quot;CiteULike&quot; /&gt;CiteULike&lt;/a&gt; &lt;a href=&quot;/external-ref?tag_url=http://cancerres.aacrjournals.org/cgi/content/long/70/21/8852&amp;title=Prognostic%20and%20Therapeutic%20Implications%20of%20Distinct%20Kinase%20Expression%20Patterns%20in%20Different%20Subtypes%20of%20Breast%20Cancer+--+Bianchini%20et%20al.%2070%20%2821%29%3A%208852+--+&amp;doi=10.1158/0008-5472.CAN-10-1039&amp;link_type=COMPLORE&quot;&gt;&lt;img src=&quot;C:\Program Files\ABS\Auto Blog Samurai\data\Breast Cancer Awareness\Medworm\complore.gif&quot; 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title=&quot;Table of Contents&quot;&gt;Table of Contents&lt;/a&gt;     This Article         Published OnlineFirst  October 19, 2010; doi: 10.1158/0008-5472.CAN-10-1039     &lt;abbr title=&quot;Cancer Research&quot; class=&quot;slug-jnl-abbrev&quot;&gt; Cancer Res November 1, 2010    70;   8852             » Abstract &lt;a href=&quot;/content/70/21/8852.full&quot; rel=&quot;view-full-text&quot;&gt;Full Text&lt;/a&gt; &lt;a href=&quot;/content/70/21/8852.full.pdf+html&quot; rel=&quot;view-full-text.pdf&quot;&gt;Full Text (PDF)&lt;/a&gt; &lt;a href=&quot;/content/70/21/8852/suppl/DC1&quot; rel=&quot;supplemental-data&quot; class=&quot;dslink-supplementary-data&quot;&gt;Supplementary Data&lt;/a&gt;  All Versions of this Article: &lt;a href=&quot;/content/early/2010/10/15/0008-5472.CAN-10-1039&quot;&gt;0008-5472.CAN-10-1039v1&lt;/a&gt; 70/21/8852 most recent       Classifications    &lt;a class=&quot;tocsection-search&quot; href=&quot;/search?tocsectionid=Tumor+and+Stem+Cell+Biology&amp;sortspec=date&amp;submit=Submit&quot;&gt;Tumor and Stem Cell Biology&lt;/a&gt; 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target=&quot;_blank&quot; rel=&quot;nofollow&quot;&gt;View the original article here&lt;/a&gt;&lt;/p&gt;</content><link rel='replies' type='application/atom+xml' href='http://nmdbreastcancerawareness.blogspot.com/feeds/6907062321009412810/comments/default' title='Post Comments'/><link rel='replies' type='text/html' href='http://nmdbreastcancerawareness.blogspot.com/2010/11/prognostic-and-therapeutic-implications.html#comment-form' title='0 Comments'/><link rel='edit' type='application/atom+xml' href='http://www.blogger.com/feeds/763914643556275777/posts/default/6907062321009412810'/><link rel='self' type='application/atom+xml' href='http://www.blogger.com/feeds/763914643556275777/posts/default/6907062321009412810'/><link rel='alternate' type='text/html' href='http://nmdbreastcancerawareness.blogspot.com/2010/11/prognostic-and-therapeutic-implications.html' title='Prognostic and Therapeutic Implications of Distinct Kinase Expression Patterns in Different Subtypes of Breast Cancer'/><author><name>Anonymous</name><uri>http://www.blogger.com/profile/14799558047407972898</uri><email>noreply@blogger.com</email><gd:image rel='http://schemas.google.com/g/2005#thumbnail' width='16' height='16' src='https://img1.blogblog.com/img/b16-rounded.gif'/></author><thr:total>0</thr:total></entry><entry><id>tag:blogger.com,1999:blog-763914643556275777.post-8228086721666630749</id><published>2010-11-07T13:14:00.000-08:00</published><updated>2010-11-07T13:14:00.153-08:00</updated><category scheme="http://www.blogger.com/atom/ns#" term="Against"/><category scheme="http://www.blogger.com/atom/ns#" term="Breast"/><category scheme="http://www.blogger.com/atom/ns#" term="Cancer"/><category scheme="http://www.blogger.com/atom/ns#" term="Green"/><category scheme="http://www.blogger.com/atom/ns#" term="Protect"/><title type='text'>Green Tea Does Not Protect Against Breast Cancer</title><content type='html'> &lt;P&gt;(Ivanhoe Newswire) -- Green tea has been the subject of medical studies for decades, and is reputed to have long-purported health benefits.  Research has shown some evidence that regular green tea drinkers have lower chances of heart disease and developing certain types of cancer.  However, a recent study reveals breast cancer isn’t included in the cancers green tea protects against.&lt;/P&gt;&lt;P&gt;&quot;Although in vitro and animal-based studies have suggested that green tea may have beneficial protective effects against breast cancer, results from human studies have been inconclusive,” which Motoki Iwasaki from the National Cancer Center, Tokyo was quoted as saying.  Our large-scale, population-based prospective cohort study is one of the first to include a wide range of tea intakes; women who drank green tea less than 1 cup per week to those who drank 10 or more cups per day.  It found no overall association between green tea intake and the risk of breast cancer.”&lt;/P&gt;&lt;P&gt;A questionnaire was used to assess the women’s tea intake at both the beginning of the study as well as five years later.  Furthermore, cancer incidence was assessed by notification from major local hospitals in the study area and data linkage with population-based cancer registries. &lt;/P&gt;&lt;P&gt;Approximately 12% of women drank green tea less than 1 cup per week while 27% drank 5 or more cups per day.&lt;/P&gt;&lt;P&gt;&quot;The other major strength of the present study was its prospective design, in which information was collected before the subsequent diagnosis of breast cancer, thereby avoiding the exposure recall bias inherent to case-control studies. Drinking green tea as a beverage is unlikely to reduce the risk of breast cancer regardless of green tea type and number of cups,” Iwasaki concluded.&lt;/P&gt;To Receive &lt;A href=&quot;http://www.ivanhoe.com/alert&quot;&gt;Med Alerts&lt;/A&gt; all year &lt;A href=&quot;http://www.ivanhoe.com/alert&quot;&gt;click here&lt;/A&gt;.&lt;B&gt;&lt;/B&gt;&lt;/P&gt;&lt;P&gt;SOURCE: Breast Cancer Research&lt;/EM&gt;, 27 October 2010&lt;/P&gt;&lt;BR&gt;&lt;br /&gt;&lt;p&gt;&lt;a href=&quot;http://www.medworm.com/index.php?rid=4122794&amp;cid=c_2_26_f&amp;fid=23290&amp;url=http%3A%2F%2Fwww.ivanhoe.com%2Fchannels%2Fp_channelstory.cfm%3Fstoryid%3D25612&quot; target=&quot;_blank&quot; rel=&quot;nofollow&quot;&gt;View the original article here&lt;/a&gt;&lt;/p&gt;</content><link rel='replies' type='application/atom+xml' href='http://nmdbreastcancerawareness.blogspot.com/feeds/8228086721666630749/comments/default' title='Post Comments'/><link rel='replies' type='text/html' href='http://nmdbreastcancerawareness.blogspot.com/2010/11/green-tea-does-not-protect-against.html#comment-form' title='0 Comments'/><link rel='edit' type='application/atom+xml' href='http://www.blogger.com/feeds/763914643556275777/posts/default/8228086721666630749'/><link rel='self' type='application/atom+xml' href='http://www.blogger.com/feeds/763914643556275777/posts/default/8228086721666630749'/><link rel='alternate' type='text/html' href='http://nmdbreastcancerawareness.blogspot.com/2010/11/green-tea-does-not-protect-against.html' title='Green Tea Does Not Protect Against Breast Cancer'/><author><name>Anonymous</name><uri>http://www.blogger.com/profile/14799558047407972898</uri><email>noreply@blogger.com</email><gd:image rel='http://schemas.google.com/g/2005#thumbnail' width='16' height='16' src='https://img1.blogblog.com/img/b16-rounded.gif'/></author><thr:total>0</thr:total></entry><entry><id>tag:blogger.com,1999:blog-763914643556275777.post-6830682811456979600</id><published>2010-11-07T04:42:00.000-08:00</published><updated>2010-11-07T04:42:00.363-08:00</updated><category scheme="http://www.blogger.com/atom/ns#" term="Breast"/><category scheme="http://www.blogger.com/atom/ns#" term="Correlates"/><category scheme="http://www.blogger.com/atom/ns#" term="Formation"/><category scheme="http://www.blogger.com/atom/ns#" term="Overexpression"/><category scheme="http://www.blogger.com/atom/ns#" term="Phosphatase"/><category scheme="http://www.blogger.com/atom/ns#" term="progression"/><category scheme="http://www.blogger.com/atom/ns#" term="Protein"/><category scheme="http://www.blogger.com/atom/ns#" term="tumor"/><category scheme="http://www.blogger.com/atom/ns#" term="Tyrosine"/><title type='text'>Overexpression of the Protein Tyrosine Phosphatase PRL-2 Correlates with Breast Tumor Formation and Progression</title><content type='html'>    Overexpression of the Protein Tyrosine Phosphatase PRL-2 Correlates with Breast Tumor Formation and Progression — Cancer Res                                            &lt;body&gt; 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&lt;a href=&quot;http://www.aacr.org/&quot; title=&quot;AACR Home&quot;&gt;AACR Home&lt;/a&gt;        Search GO   &lt;a href=&quot;/search&quot;&gt;Advanced Search&lt;/a&gt;                      User Name  Password   Sign In                              &lt;a href=&quot;/cgi/adclick/?ad=25951&amp;adclick=true&amp;url=http%3A%2F%2Fwww.aacr.org%2Fmeetingcalendar&quot;&gt;&lt;img class=&quot;adborder0&quot; title=&quot;AACR&quot; src=&quot;http://cancerres.aacrjournals.org/adsystem/graphics/9526130191797045/canres/Mtgs_Workshops430x90.jpg?ad=25951&amp;adview=true&quot; alt=&quot;AACR&quot; /&gt;&lt;/a&gt; &lt;a href=&quot;/cgi/adclick/?ad=24926&amp;adclick=true&amp;url=http%3A%2F%2Fwww.cancercareers.org&quot;&gt;&lt;img class=&quot;adborder0&quot; title=&quot;Cancer Careers&quot; src=&quot;http://cancerres.aacrjournals.org/adsystem/graphics/9526130191797045/canres/cancercareers430x90.jpg?ad=24926&amp;adview=true&quot; alt=&quot;Cancer Careers&quot; /&gt;&lt;/a&gt;       Overexpression of the Protein Tyrosine Phosphatase PRL-2 Correlates with Breast Tumor Formation and Progression   &lt;a class=&quot;name-search&quot; href=&quot;/search?author1=Serge+Hardy&amp;sortspec=date&amp;submit=Submit&quot;&gt;Serge Hardy&lt;/a&gt;,   &lt;a class=&quot;name-search&quot; href=&quot;/search?author1=Nau+Nau+Wong&amp;sortspec=date&amp;submit=Submit&quot;&gt;Nau Nau Wong&lt;/a&gt;,   &lt;a class=&quot;name-search&quot; href=&quot;/search?author1=William+J.+Muller&amp;sortspec=date&amp;submit=Submit&quot;&gt;William J. Muller&lt;/a&gt;,   &lt;a class=&quot;name-search&quot; href=&quot;/search?author1=Morag+Park&amp;sortspec=date&amp;submit=Submit&quot;&gt;Morag Park&lt;/a&gt;, and   &lt;a class=&quot;name-search&quot; href=&quot;/search?author1=Michel+L.+Tremblay&amp;sortspec=date&amp;submit=Submit&quot;&gt;Michel L. Tremblay&lt;/a&gt;   &lt;a id=&quot;aff-1&quot; name=&quot;aff-1&quot;&gt;&lt;/a&gt;&lt;address&gt;&lt;strong&gt;Authors&#39; Affiliation:&lt;/strong&gt; The Goodman Cancer Center and Department of Biochemistry, McGill University, Montreal, Quebec, Canada     &lt;strong&gt;Corresponding Author:&lt;/strong&gt;&lt;br /&gt; Michel L. Tremblay, The Goodman Cancer Center, McGill University, 1160 Des Pins Avenue West, Cancer Pavilion, Room 617, Montreal, Quebec, Canada H3A 1A3. Phone: 514-398-7290; Fax: 514-398-6769; E-mail: michel.tremblay{at}mcgill.ca.     Abstract The PRL-1, PRL-2, and PRL-3 phosphatases are prenylated protein tyrosine phosphatases with oncogenic activity that are proposed to drive tumor metastasis. We found that PRL-2 mRNA is elevated in primary breast tumors relative to matched normal tissue, and also dramatically elevated in metastatic lymph nodes compared with primary tumors. PRL-2 knockdown in metastatic MDA-MB-231 breast cancer cells decreased anchorage-independent growth and cell migration, suggesting that the malignant phenotype of these cells is mediated at least in part through PRL-2 signaling. In different mouse mammary tumor–derived cell lines overexpressing PRL-2, we confirmed its role in anchorage-independent growth and cell migration. Furthermore, injection of PRL-2–overexpressing cells into the mouse mammary fat pad promoted extracellular signal-regulated kinase 1/2 activation and tumor formation. MMTV–PRL-2 transgenic mice engineered to overexpress the enzyme in mammary tissue did not exhibit spontaneous tumorigenesis, but they exhibited an accelerated development of mammary tumors initiated by introduction of an MMTV-ErbB2 transgene. Together, our results argue that PRL-2 plays a role in breast cancer progression. Cancer Res; 70(21); 8959–67. ©2010 AACR. &lt;/p&gt;   Footnotes   &lt;strong&gt;Note:&lt;/strong&gt; Supplementary data for this article are available at Cancer Research Online (&lt;a href=&quot;http://cancerres.aacrjournals.org/&quot;&gt;http://cancerres.aacrjournals.org/&lt;/a&gt;). &lt;/p&gt;     Received June 10, 2010.  Revision received September 9, 2010.  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title=&quot;Table of Contents&quot;&gt;Table of Contents&lt;/a&gt;     This Article         Published OnlineFirst  September 14, 2010; doi: 10.1158/0008-5472.CAN-10-2041     &lt;abbr title=&quot;Cancer Research&quot; class=&quot;slug-jnl-abbrev&quot;&gt; Cancer Res November 1, 2010    70;   8959             » Abstract &lt;a href=&quot;/content/70/21/8959.full&quot; rel=&quot;view-full-text&quot;&gt;Full Text&lt;/a&gt; &lt;a href=&quot;/content/70/21/8959.full.pdf+html&quot; rel=&quot;view-full-text.pdf&quot;&gt;Full Text (PDF)&lt;/a&gt; &lt;a href=&quot;/content/70/21/8959/suppl/DC1&quot; rel=&quot;supplemental-data&quot; class=&quot;dslink-supplementary-data&quot;&gt;Supplementary Data&lt;/a&gt;  All Versions of this Article: &lt;a href=&quot;/content/early/2010/09/13/0008-5472.CAN-10-2041&quot;&gt;0008-5472.CAN-10-2041v1&lt;/a&gt; &lt;a href=&quot;/content/early/2010/10/07/0008-5472.CAN-10-2041&quot;&gt;0008-5472.CAN-10-2041v2&lt;/a&gt; 70/21/8959 most recent       Classifications    &lt;a class=&quot;tocsection-search&quot; 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