Health Care Review...

Benefits and Efficacy Honeycomb (Propolis) for Health

2016-04-21T17:57:00.000-07:00

Propolis Benefits and Benefits for Health

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Bees are very many benefits, ranging from the properties of honey to a bee sting is painful also has its benefits (usually used for therapy). But this time we will discuss are the properties of the honeycomb. Honeycomb or propolis is one good result of the bee, the bee hive contained various vitamins and minerals that are beneficial as antioxidants such as bioflavonoid. From the results of the study showed that eight million species of insects, only bees that had substance impenetrable immunity bacteria. To keep the nest, the colony of eggs, and the larvae of bees in it remains sterile and perfect eggs can hatch, bees produce bee propolis. Honeycomb or Propolis is made from materials collected by bees from flowers, young leaves or shoots of plants and tree bark. Then the bees processing with enzymes or saliva and mixed with wax in the hive and used to patch holes or cracks in the hive, as well as protect from the attack of bacteria, fungi, and viruses. Propolis is also a natural antibiotic that can help fight the disease, which can be useful to protect us from the threat of bacteria and viruses, to help control free radicals that can cause cancer, as well as the perfect nutritional source of food complete with unlimited potential.The content of Honeycomb / PropolisBased on chemical analysis, bee propolis is rich in various compounds that are antibiotic. Honeycomb have perfect hexagonal structure, formed of strands of mucous substances that come from their own body, in addition to containing a liquid honey also other liquids such as resin. One of the special ingredients contained in propolis is a bioflavonoid. Propolis contains protein (16 amino acids free), minerals, especially iron and zinc, vitamin A, B complex, C, D, E, Biotin, Bioflavonoids, Glucose, and substances other essential nutrients. Bioflavonoids have the ability to recover the system capillaries, improving brittleness and leakage of blood vessels. In one drop of propolis are bioflavonoids equivalent of 500 oranges. An estimated 200,000 bees only produced 20 grams of propolis in one year. Propolis can strengthen and accelerate the regeneration of cells, so that it can act as a remarkable healer.1. As Anti Fungus, Virus and Bacteria

Viruses multiply in the protein layer. Over this layer is not broken, then the harmful substances from the virus will not harm the human body. This protein layer can protect it with the help of Bioflavonoid. Terakhiir research from the National Heart and Lung Institute in London showed that bioflavonoids propolis is able to destroy many bacteria that are resistant to anti-biotic synthesis.Propolis sensitive Staphyococcus, Streptococcus, E. coli, Ifluensa virus, Herpes, H.Pilori, Salmonella typhosa. Propolis is also sensitive to the fungus that causes the disease female (white) exim.

2. Anti-Oxidant

In all the metabolic processes of the body, especially the reaction with oxygen to form molecules that lack an electron (unpaired) on the outer skin. These substances called free radicals (free radicals) are very reactive and tends to attack normal cells that can give electrons.If this teradi the normal cells will give electrons will be deformed cells. If not destroyed by the immune system, the cells are defective will cause various diseases in accordance with the position where the defective cells that are in Antung jantung.Begitu will cause disease when there is a lung would cause lung disease and so on ,However besyukurlah us because God has provided a natural substance that voluntarily give electrons to neutralize free radicals. This substance is called a natural anti-oxidant and one of them contained in Propolis are Vitamins A, C, E and natural enzymes such as glutathione peroxydase (GPS), superoxida dismutate (SOD) and catalase.

3. As an immune system stimulator (immuno stimulator)

When the body's immune system decline, for example in patients with AIDS, many happen destruction of lymphocytes (T4-Cell), so patients eventually result infeksi.Begitu meninngal also with cancer patients in general have a weak immune system, due to toxin sitostatika danterapi tumor, radiation or surgery ,Immune Stimulator indirectly efficacious reactivate the immune system, with an increasing non-specific immune response, such as by multiplying Limfo-T4.NK-cell and stimulated macrophages and interleukin. The final effect of the complex reactions that are foreign substances that can be identified and destroyed, including cell; defects, viruses, and bacteria.Bioflavonoids role in this process is enhancing the immune system work by increasing the activity and increase Limfo-T and Macrophages are very useful in wiping out foreign substances in the body, such as fungus, viruses, bacteria-free cells.

4. Atherosclerosis

Atherosclerosis is the calcification of blood vessels by cholesterol contaminated by radical bebas.Kolesterol aringan mostly transported from the liver through the blood vessels in the form of LDL cholesterol. LDL cholesterol is oxidized by free radicals in the blood vessels to form oxy-LDL.Oksi-LDL is deposited on the walls of blood vessels and result in untreated tidk Atherosklerosis.Atherosklerosis which will cause various diseases, such as high blood pressure, coronary heart disease and stroke.

5. Anti-Tumor

Tumor cells are a group of disabled / free suddenly became uncontrollable, multiply rapidly and continuously.Defects in these cells caused by reduced anti-oxidant body to protect cells from free radical attack.

6. As Anti Prostaglandin

Stopping the activity of inflammation by inhibiting prostaglandin expenditure (hormones that cause inflammation).This effect which works on cases penyakitr rheumatoid arthritis (arthritis, gout), nephritis and others.

7. Helping The regeneration of liver cells

Hepatitis is a disease cirrhosis of the liver with the criteria:1.Matinya liver parenchymal cells2.Pembentukan actively connective tissue3.Proses regeneration of liver cells disrupted.Propolis, helping the regeneration of liver cells to work well and improve the immune system to eat the liver cells are already dead so as to reduce the formation of connective tissue (scar tissue).

8. Diabetes mellitus (diabetes)

Diabetes mellitus is a disease characterized by increasing levels of sugar in the blood due to decreased insulin production.Propolis stimulates pancreas cells to actively improve insulin so that glucose in the blood can be normal.Propolis sensitive to the cause pyloric ulcer disease and gastric ulcer (ulcers), also against E. coli (cause of diarrhea) and Salmonella typhosa (causes typhoid)

9. Gastrointestinal Disorders

Propolis sensitive to the cause pyloric ulcer disease and gastric ulcer (ulcers), also against E. coli (cause of diarrhea) and Salmonella typhosa (causes typhoid)

10. Respiratory Disorders

Propolis helps system pertahannan body fight chronic respiratory diseases such as tuberculosis, protects lung cells from radical damage bebas.Propolis also play a role in the treatment of asthma because of its performance as a bronchodilator (dilate bronchi), stabilizes mast cells and reduce costs Histamine.

11. Heart and Blood Vessels

Propolis can overcome the effects of free radicals on the heart, increasing the pumping power of the heart, preventing blood vessel stiffness (hypertension), to prevent the formation of thrombus (Stroke and Coronary Heart)

12. Wound Care

Propolis as a disinfectant bioflavonoids and vitamin C contained therein, fully contributes to wound healing by speeding tmbuhnya new network.

13. Anti Stress

Propolis can suppress the parasympathetic nervous system in order to express pleasure and suppress fear, relaxing, making it useful for people with mental disorders.

Dance Batok Padang, West Sumatera

2016-03-31T00:48:00.002-07:00

Gout

2016-03-31T00:39:00.000-07:00

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Gout is a result of excessive consumption of purine substances. Purines into uric acid is processed body, but if excess uric acid levels, so that the kidneys are unable to remove uric acid crystals accumulate in the joints. As a result, joint pain, swollen and inflamed.

Uric acid is a disease of purine metabolic waste substances that come from the rest of the food we eat. Purine itself is a substance contained in each food derived from living bodies. In other words, in the living body are purine substance, and then because we eat living creatures, then to proceed to the purine substance in our body. A variety of vegetables and fruits also are purines. Purine also resulted from the destruction of body cells which occur normally or because of certain diseases. Usually gout attack in the elderly, because this accumulation of purines.

Abstinence gout sufferers

Offal: brains, lungs, liver, spleen, intestines, kidneys and tripe.
Seafood (seafood): shrimp, crab, squid, octopus, clams, cuttlefish, mussels, oysters, anchovies, sardines.
Riverfood (Food rivers): catfish, eel, shrimp, crabs and snails.
Meat extracts such as shredded and jerky.
Food that has been canned (example: corned beef, sardines, beef and pork).
Mutton, dog meat, pork, beef, buffalo meat and horse meat.
Ducks, geese and turkeys.
Birds and bats.
Legumes: soybeans (including processed products such as tempeh, tofu, tauco, oncom, soy milk), peanuts, green beans, bean sprouts and chips / melinjo.
Vegetables: cauliflower, spinach, asparagus, beans, mushroom, leaves of cassava / sweet potato, papaya, spinach and chilli / chilli.
Cream, ice cream and broth or gravy is thick.
Certain fruits such as durian, pineapple and coconut water.
Fried foods or bersantan or cooked using margarine / butter.
Foods rich in protein, fat and blood.
Additional ips for gout sufferers
Consumption of foods containing high potassium such as tomatoes, potatoes, yogurt and bananas.
Consumption of fruits that contain lots of vitamin C, such as oranges, papaya and strawberries.
Examples of fruit and vegetables to treat gout: dragon fruit, starfruit, ginger, pumpkin, mustard greens, chicory, lemon grass and tomato.
Increase consumption of complex carbohydrates such as rice, cassava / sweet potatoes and bread.
Reduce consumption of simple carbohydrates such as type of fructose sugar, candy, cotton candy, cotton candy and syrup.
Do not take aspirin.
Do not overwork / fatigue.
In people who are overweight (obesity), usually uric acid levels quickly rise but spending a bit, then you should lose weight with exercise.
Adjust energy intake with the body's needs, based on height and weight.

To cure this disease there are several things that must be done, including:

Avoid foods that can increase uric acid, such as organ meats (liver, kidney, spleen, tripe, intestines, lungs and brain), avoid seafood (shrimp, scallops, squid, crab); canned food (corned beef, sardines and meat extract), broth or gravy is thick.

Avoid foods like chips / melinjo, kale and spinach, cassava leaves / cassava, cashew leaves, asparagus, green beans and cauliflower. Avoid nuts (peanuts, green beans, soybeans, tempeh, tauco, bean sprouts, oncom) and soy milk.

Women who go jogging a week before their period is due risk damaging their knees

2012-10-16T21:51:00.003-07:00

Women who work out regularly should consider taking it easy in the week before their period is due - as they could be at greater risk of injury, say scientists. Researchers found that the nerve fibres around their knee muscles fired more often during this week than earlier in their menstrual cycle. They said this difference in firing rate could affect the stability of the joint, potentially making it more susceptible to injury. Sportswomen typically suffer from more knee injuries than their male counterparts, especially in sports such as football that involve knee twisting and turning. Previous studies found women were also more likely to experience ligament tears and chronic pain. Researchers set out to see if hormone levels could be part of the problem, by affecting muscle-controlling nerves. Working with female volunteers aged between 19 and 35, the team from the University of Texas-Austin and University of North Carolina, charted their menstrual cycles by taking body temperature measurements every morning. It is possible to track where a woman is on her menstrual cycle because body temperature increases slightly after ovulation and dips to pre-ovulation temperatures just before the start of a new cycle. Hormonal levels also fluctuate during the cycle, with progesterone and estrogen levels falling in the final week before menstruation. More... Breast cancer timebomb fear: Experts warn that NHS faces crisis as number of women living with disease is set to treble to 1.7m Playing football is the best way for middle-aged men to tackle high blood pressure The scientists also measured the women's motor activity in their knees at five different points during the study. They inserted a fine wire electrode into two knee muscles and took readings as the women performed simple knee extensions. The results from the seven women revealed that the rate of nerve firing in these muscles jumped in the third week of the menstrual cycle, known as the 'late luteal phase'. Research leader Professor Matthew Tenan, from the University of Texas-Austin, said: 'Our results suggest that muscle activation patterns are altered by the menstrual cycle. 'These alterations could lead to changes in rates of injury.' He said further investigation was now needed to see whether these results coincide with a difference in knee injury rates at different points in the menstrual cycle. The study was presented at The Integrative Biology of Exercise conference held in Colorado. Read more: http://www.dailymail.co.uk/health/article-2218520/Why-jogging-week-period-damage-knees.html#ixzz29WqmIoKo Follow us: @MailOnline on Twitter | DailyMail on Facebook

12 Ways to Fight Stress and Help Your Heart

2012-07-22T19:16:00.001-07:00

Relax! You can help your heart by learning how to de-stress, chill out, and let it go. Here are 12 ways to get yourself closer to the Zen zone.

Can stress hurt your heart?

By Amanda Gardner
The evidence is piling up that the answer is—yes, stress is bad for your ticker.

“There are studies to show that stress is comparable to other risk factors that we traditionally think of as major, like hypertension, poor diet, and lack of exercise,” says Kathi Heffner, PhD, assistant professor of psychiatry at the Rochester Center for Mind-Body Research at the University of Rochester Medical Center in New York.

Here are 12 steps you can take to fight stress and protect your heart.

1. Focus on relaxation

Stress-reduction techniques and exercises such as yoga, meditation, and tai chi have been shown to lower stress hormones and bolster immune function, says Heffner.

In one study, people who practiced yoga regularly experienced a decrease in some of their body’s inflammatory responses. Inflammation is emerging as a key culprit in heart disease, among many other chronic conditions.

"Dedicating a certain time of the day to focus on your body and on actually relaxing, (not) caring about the other things that are going on your day, is very useful," says John Simmons Jr., MD, assistant professor of family medicine at Texas A&M Health Science Center College of Medicine in Bryan.

2. Connect with friends

Spending too much time on your own can affect not only your mental health but your heart health as well. This holds true whether or not you’ve been actually diagnosed with heart disease.

According to one study, women in particular were more prone to angina, a heart-disease-related chest pain, and other problems if they had little social support when they were recovering from a heart attack.

So get out and about. However, make sure you’re connecting with true friends. “If you have a lot of friends but they’re all mean to you, that won’t be beneficial,” Heffner says. And that’s backed up by research.

3. Forget perfect

We all know that the type A personality—the one constantly striving for perfection—seems more prone to heart disease. But what it really boils down to, says Heffner, is hostility. "Hostility has been shown to be the key ingredient in what used to be termed the type A personality," she says. "Hostility is behavior that's fueled by anger toward other people." Research suggests that hostility may be a better predictor of heart disease than things like high blood pressure and being overweight.

So play nice and think nice thoughts about the future, as optimism has also been shown to protect the heart.

4. Don’t hold grudges

Nursing a grudge isn't going to help in the heart-health department. Research suggests that people experience more psychological stress and higher heart rates when they hold grudges than when they grant forgiveness.

"You would be amazed at how strongly they can take root in your psyche and how long they can gnaw at you. Getting that monkey off your back psychologically is very important, and allows you to move on and quit perseverating," Dr. Simmons says.

So be quick to forgive. This is also likely to lead to better social relationships, another boost for the heart, Heffner says.

5. Lighten up

Laughter can burn up to 20% more calories than keeping that poker face, according to a 2005 study, which monitored adults while they watched funny and not-so-funny film clips.

And fewer calories, as we all know, mean a better chance of staying slim, which is one of the best ways to protect your heart for the long-term. Mirth also increased heart rate and, in a 2010 study in the American Journal of Cardiology, was shown to improve vascular function. So laugh a little or, better yet, a lot. The first study found that the more you laugh, the more calories you use up and the harder your heart works.

6. Don’t drink (too much) alcohol

Having too many drinks can raise triglycerides and blood pressure and even lead to heart failure. However, moderate drinking may actually ward off heart disease. Moderate means no more than one drink a day for women and two for men.

If you don’t drink, this isn't a reason to start, according to Dr. Simmons. "But if you have always enjoyed a glass of wine and want reassurance, it's perfectly fine," he says.

7. Cut the caffeine

Caffeine can quickly raise your fight-or-flight response and all the attendant stress hormones, explains Dr. Simmons.
Elevated stress hormones contribute to inflammation. So cut down on your coffee or tea habit. And even your diet soda habit. Preliminary studies have linked diet sodas to an increased risk of diabetes, a major risk factor for heart disease.

8. Limit emotional involvement

Not with people! But avoid getting too emotionally invested in things that don’t matter that much.

For example, researchers recently linked football team losses with a greater risk of heart attack. In Los Angeles County, deaths from heart attacks and just deaths in general (mostly in elderly people) spiked after the Pittsburgh Steelers routed the Los Angeles Rams 31-19 in the 1980 Super Bowl. But when the Rams pounced the Washington Redskins 38-9 in 1984, deaths in the county declined. So don’t sweat the small stuff and remember that it's all small stuff.

9. Eat right

Eating a balanced diet—low in red meat and processed foods, high in fruits and vegetables, poultry, fish, and whole grains—will not only keep your weight down but also have a more direct effect on the heart’s functioning: It keeps your blood sugar stable throughout the day so you can avoid destructive peaks and valleys. "Eating a more balanced diet with complex carbs means you’re going to be stable throughout the day," Dr. Simmons says. "You're not going to have a carb high, then a drop down. Your mood isn’t going to fluctuate."

Healthy eating can help prevent or delay diabetes, a major risk factor for heart trouble.

10. Seek help for depression

Depression can increase the risk of heart disease and may shorten life span. If you’re depressed, medication, psychotherapy or cognitive behavioral therapy, and other treatments may help. The Cleveland Clinic recommends antidepressants known as selective serotonin reuptake inhibitors (SSRIs, such as Prozac and Zoloft) because they don’t raise blood pressure.

But ask your doctor if this is the best drug for your depression and make sure you know about any interactions.

11. Get some sleep

So many people in our sleep-deprived culture just aren’t getting enough z’s, or enough of the right kind of rest. An average of six to eight hours of sleep is recommended, according to Dr. Simmons.

However, quality of sleep is key. Sleep apnea—a condition in which you wake up periodically due to interrupted breathing—has been linked with cardiovascular disease.

People who awake in the middle of the night from sleep apnea are unable to complete normal sleep cycles, a time when the body naturally lowers hormone levels and blood pressure. This can lead to hypertension and heart disease.

12. Exercise more

Want a cure-all? Try aerobic exercises like running, walking, swimming, and even dancing. These activities help you feel better, lower your risk for diabetes, and make your heart stronger, a trifecta of health benefits. Exercise can also help depression.

Study after study has shown the benefits of physical activity, even active housework or gardening. The reason? It pumps your heart, moving blood all around the body.

The American Heart Association recommends exercising aerobically at least 30 minutes all or most days of the week. But talk to your doctor before hitting the track.

Source : http://www.health.com
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Do Stressful Jobs Fuel Heart Attacks?

2012-07-22T19:02:00.001-07:00

By Amanda Gardner

Getty Images

After a bad day at work, do you ever complain to your friends that your high-pressure job or demanding boss is giving you a heart attack? It’s just a figure of speech, but you might actually be on to something.

According to a new study of more than 22,000 female doctors and nurses, being in a stressful work situation increases a woman’s risk of heart attacks and related problems, possibly because the stress contributes to high blood pressure and other hazards.

Women who reported high levels of job strain were two-thirds more likely to have a heart attack during a 10-year period compared with women in easygoing jobs, the study found. Women in high-strain jobs were also 41% more likely to require a heart procedure such as bypass surgery.

Job strain isn’t exactly the same as job stress. When researchers talk about job strain, they’re referring to a specific type of psychological stress that’s “basically a combination of how demanding one’s job is and how much control one has over one’s job,” says Michelle Albert, M.D., the senior author of the study.

Challenging, fast-paced jobs aren’t necessarily straining. High-strain jobs are very demanding, yet they also involve little control or authority (picture working 12-hour days while being micromanaged). Low-strain jobs, on the other hand, feature relatively few demands and high levels of day-to-day control.

Chronic stress can lead to anxiety and depression, both of which have been linked to heart disease. In this study, though, anxiety and depression—along with other risk factors, such as smoking and body mass index—contributed only slightly to the relationship between job strain and heart attacks, suggesting that other factors were at play.

Women with high-stress jobs may be more likely to have a heart attack

2012-07-22T18:59:00.000-07:00

(CBS News) Stress at work may have an adverse effect on your heart health if you're a woman.

A new study shows that women who have high-stress jobs are 67 percent more likely to have a heart attack and 38 percent more likely to have any kind of cardiovascular event than women who have more low-stress jobs.

Elevated job strain, a form of psychological stress, has long term cardiovascular health effects in women and could suggest the need for health care providers to incorporate assessment of and identification of useful interventions that minimize the effects of job strain," Dr. Michelle A. Albert, of Brigham and Women's Hospital and Harvard Medical School,wrote in the study.

The study, published in the July 18 issue of PLoS ONE, looked at more than 22,000 women working in the health care industry in the United States who were part of the Women's Health Study. Their average age was 57, and the women were predominantly white.

Women's jobs were divided into four categories: low strain (low demand, high control); passive (low demand, low control); active (high demand, high control) and high strain (high demand, low control). The women were monitored for the number of heart attacks, strokes, heart procedures and deaths that occurred after a 10-year follow-up period.

"High strain is defined as high demand and low control," Albert told WebMD, using as an example a factory job in which a worker is pressured to produce.

While the researchers found higher rates of heart problems among women with high-strain jobs, they did not find any increased long-term cardiovascular risk in women who reported job insecurity. Women with active strain jobs, such as managers, were also shown to have this increased risk.

Depression and anxiety, which are risk factors for heart disease, were found only to slightly contribute to the link between stress and heart problems in women. Albert told Health.com that job stress may lead to over-activation of the body's stress system, releasing stress hormones which may lead to higher blood pressure, insulin resistance and other processes that may damage the heart's blood vessels.

She told CBS station WBZ in Boston that it's important for women to recognize when stress is taking a toll, whether it's chest pains, frequent headaches or feeling overly "worked up."

She recommends to maintain a healthy lifestyle, women should increase their physical activity, lean on social support and make sure they have time to allow themselves to de-stress.

"You're not going to get rid of stress," said Dr. Albert. "Stress is a normal part of life."

12 tips for healthy hair: get the shine, movement and softness you desirefast and easywith our expert advice from top pros

2012-07-20T19:44:00.000-07:00

by Kathy Miller Kramer

Hair is the ultimate accessory; it can add to (or detract from) your overall look instantly. Keeping it in healthy condition is the most important thing you can do to help it look and feel fabulous. And, while it seems easy, this isn't as simple as minimizing chemical treatments or slathering on a weekly deep conditioner. While these can make your strands softer and less split-end-prone, what really matters is the daily handling; this is what creates the most stress--and potential damage--to your tresses. To help your locks look their best, we asked top experts from around the country for their advice on how to baby your mane every single day. So whether your concern is dullness, damage, frizz or fragility, we have the answers to ease even the toughest hair-care woes. Read on for tips to achieve run-your-fingers-through-it hair.

1 Steer clear of plastic-bristle brushes. "The proper bristles are key," says stylist Edward Tricomi of the Warren-Tricomi Salon in New York City. "A combination of natural boar bristles on either a round or flat brush are best for dry hair, while soft, rubber-toothed wide-paneled brushes are best for damp hair." Our favorite brushes include the Mason Pearson Boar Bristle brush ($78.50; zitomer.com) and Aveda's Wooden Paddle Brush ($17; aveda.com).

2 Brush before shampooing. A few gentle strokes on dry hair will help remove product buildup and scalp flakes, as well as stimulate the scalp and promote blood flow (which delivers nutrients like oxygen) to hair follicles. For a smoother slide, try Clairol Herbal Essences Let It Loose Detangling Spray ($3; at drugstores).

3 Know your water. If your hair looks dull or is hard to style, the problem could be your tap water. According to Minneapolis-based Gordon Nelson, international creative director for Regis Salons, well water contains natural minerals (called "hard water") that can leave hair lusterless and hard to manage and can impart a brassy, orange hue. Soft water, on the other hand, has fewer damaging minerals. (Ask your local water department if your water is soft or hard, or try using Robert Craig's No More Bad Hair Days Kit, $20; robertcraig.com; with strips to test your water.) To rid hair of mineral buildup, suds up every week with a clarifying shampoo. We like Frederic Fekkai Apple Cider Clarifying Shampoo and Clean Conditioner ($18.50 each; saks.com).

4 Mist your ends with water before home coloring. The ends of your hair are more porous and, as a result, absorb more pigment. "Wet hair doesn't absorb color as readily as dry hair," explains Renee Patronik, a consulting colorist for L'Oreal in New York.

5 Trim your troubles. As the ends of your hair get older and damaged by rough handling, they become prone to splitting, Nelson says. Get regular trims, at least 1/2 inch every four to eight weeks. "Hair grows (on average) half an inch per month, so trim to maintain healthy ends," says stylist Stephen Knoll of the Stephen Knoll Salon in New York.

6 Use color-protective products. Chemical treatments like color can damage hair because the chemicals have to penetrate the outer layer of the hair (or cuticle) to allow the hue to be absorbed, explains stylist Rodolfo Valentin of Rodolfo Valentin Atelier for Hair in New York. Color-protective products are specially designed to minimize dryness, keep color true and prevent damage. "They typically have more nourishing ingredients, strip less color and are less abusive," Knoll explains. We love L'Oreal VIVE Color Care Shampoo and Conditioner ($3.69 each; at drugstores) and Matrix Biolage Color Care Shampoo ($10) and Conditioner ($11; matrix.com for salon locations).

7 Give wet hair extra TLC. It stretches and snaps more easily than dry hair does, so be extra-gentle with it. "Use a wide-tooth plastic comb while hair is wet; then, once it's towel-dried, switch to a good brush," says Jon Patrick, color director of the Mete Turkmen Hair Salon Plus in New York. And avoid wooden combs; wood can have microscopic divots that snag hairs. Instead try the Jilbere de Paris plastic shower comb ($1.49; sally beauty.com for store locations).

8 Deep condition once every two weeks. "These treatments penetrate the hair shaft and strengthen strands," says Patrick, who adds that using heat (from a blow-dryer) can intensify deep conditioning, as the heat causes the cuticle to open and the ingredients to penetrate.

For nourishing results, try Kerastase Masquintense ($36; 877-748-8357 for salons), available for fine or thick hair; Neutrogena Triple Moisture Sheer Hydration Leave-In Foam ($7; at drugstores); or Ellin Lavar Textures ReconstructMasque ($25; ellinlavar.com).

9 Try an ionic dryer. Ions are atoms with a positive or negative charge. These particular hair-dryers bathe your hair in negative ions, which help break up water molecules faster and cancel out hair-damaging positive ions, Valentin explains. Plus, your hair-drying time is cut in half. We love the Bio Ionic Super-Hydrator Pro Dryer ($165; bioionic.com for salon locations).

10 Just use your dryer's nozzle, urges stylist Frank Galasso of Frank.Studio in Santa Monica, Calif. It's the best way to help prevent frizz because it concentrates the airflow on sections. "Without a nozzle the dryer's grill gets very hot; if your hair gets too close to it, it will cause damage and/or breakage," explains stylist Mark Garrison of the Mark Garrison Salon in New York.

For curls, use a diffuser attachment to gently surround your hair with air. Try Vidal Sassoon Ceramic Finger Diffuser ($8; hotus.com for store locations). Follow up with John Frieda's Frizz-Ease Secret Weapon Flawless Finishing Creme ($6; at drugstores) to smooth strands.

11 Give textured or relaxed hair a break. African-American hair tends to be coarse due to a lack of natural oils (more so if chemically processed), says New York-based celebrity hairstylist Ellin Lavar. Lavar suggests opting for gentle color choices like semipermanent or vegetable color. Spacing processing treatments at least two weeks apart, with weekly conditioning treatments in between for shine maintenance, helps.

12 Use the right accessories. Kim Vo, a stylist at West Hollywood's B2V Salon, suggests putting hair in soft braids or twists and using claw clips rather than barrettes, which can pull hair. Other options: gentle Goody Ouchless elastic bands ($3 for 14; at drugstores) and L. Erickson Grab 'N Go Pony O's ($12 for three; franceluxe.com).

RELATED ARTICLE: POINT & CLICK FOR HEALTHY HAIR

For great styling advice that doesn't sacrifice hair health, check out the Dove Styling Tool, a tip-filled interactive guide created with the help of top celebrity stylist Eva Scrivo. It's organized according to the look you're trying to achieve. Find it at dove.com/unstick_your_style.

BAN BAD-HAIR DAYS We're giving 50 lucky Shape readers the chance to try Robert Craig's No More Bad Hair Days Kit (a $20 value!). The kit includes 12 water test strips, three shampoos for different water types (soft, moderately hard and extremely hard) and a leave-in conditioner. Visit Shape.com/RobertCraig from Oct. 18 to Nov. 14 for your chance to win. Good luck!

KATHY MILLER KRAMER is a New York City-based freelance writer. Additional reporting by CARLY CARDELLINO.

The sour truth about apple cider vinegar - evaluation of therapeutic use

2012-07-17T19:42:00.001-07:00

by Beth Fontenot

Apple cider vinegar is an old folk remedy claimed to be beneficial in treating a long list of ailments. Proponents say that it can cure arthritis, guard against osteoporosis, lower blood pressure and cholesterol, prevent cancer, destroy infection, assist in digestion and weight control, maintain memory, and protect the mind from aging.

Vinegar is said to have been used for medical ailments for at least 10,000 years. The Babylonians first converted wine into vinegar in 5000 BCE using date palms, grapes, and figs, and believed vinegar had exceptional healing properties. Hippocrates is said to have used vinegar as an antibiotic. Samurai warriors supposedly used a vinegar tonic for strength and power. During the U.S. Civil War, soldiers used vinegar to prevent gastric upset and as a treatment for various ailments including pneumonia and scurvy. It was used to treat wounds during World War I.

The name vinegar comes from a French word meaning "sour wine." It is produced by the action of yeast and bacteria on grains or fruit juices. Vinegars take their name from the material used to make the vinegar, i.e., apple cider vinegar comes from apples, wine vinegar comes from grapes.

Apple cider vinegar is made by crushing apples and squeezing out the liquid. Sugar and yeast are added to the liquid to start the fermentation process, which turns the sugars into alcohol. In a second fermentation process, the alcohol is converted by acetic acid-forming bacteria into vinegar. Acetic acid gives vinegar its sour taste.

"Mother of vinegar" is a term used to refer to the mass of scum that forms on top of cider when alcohol turns into vinegar, or to the cloudy substance that sometimes develops in stored vinegar. It is actually bacteria and yeast cells that have died.

Folk Claims

In 1958 Dr. D. C. Jarvis, a "noted Vermont country doctor," wrote a book entitled Folk Medicine in which he extolled the virtues of vinegar. He claimed that Vermonters knew how to cure migraine headaches, diabetes, chronic fatigue, arthritis, and a variety of other ailments. They used apple cider vinegar.

Among Dr. Jarvis's many tenets about apple cider vinegar was his advice to pregnant women to drink an apple cider vinegar tonic daily to assure that the infant is born with "an excellent chemical pattern with which to meet its new environment." He recommended the same tonic for those suffering from arthritis. Believing that apple cider vinegar would destroy bacteria in the digestive tract, he advised those with GI problems to consume a tonic with each meal. He also declared that the regular consumption of an apple cider vinegar tonic would make body fat disappear because the vinegar would cause the fat to be burned instead of stored.

His book quickly sold 500,000 copies and is still in print. Apple cider vinegar is still promoted as one of the chief "natural" remedies for arthritis.

Those who believe that apple cider vinegar has miraculous properties attribute its powers to an abundance of nutrients in the liquid. One company's sales pitch states, "Each golden drop is a natural storehouse of vitamins and minerals." Marketers point to the trace minerals, bacteria,. and enzymes present in their product as the ingredients that give apple cider vinegar its curative characteristics. Another company suggests that their apple cider vinegar is superior because it contains pectin, beta-carotene, and potassium in addition to enzymes and amino acids. Apple cider vinegar is also said to contain an abundance of complex carbohydrates and dietary fiber. Dr. Jarvis believed that the healing properties of apple cider vinegar were due in large part to its rich potassium content.

Some New Twists

Apple cider vinegar is sold today by "health food" companies and others who claim it has remedial properties. The claims are similar to those in the past, but some have taken on a modem twist based on more recent medical research.

Marketers contend that the beta-carotene in apple cider vinegar destroys free radicals in the body which are involved in the aging and mutation of tissues and in destroying the immune system. Apple cider vinegar's beta-carotene is said to be in a "natural, easy to digest form."

Its use as a remedy for arthritis is based on the notion that acid crystals harden in the joints and tissues which cause the joints to become stiff and the tissues to harden. These acid crystals also cause the body to age prematurely, so the ads state. Apple cider vinegar is supposed is put these acid crystals in solution so they can be flushed from the body.

Producers also claim that apple cider vinegar can lower cholesterol and blood pressure. These assertions are based on the assumption that people naturally crave acids when eating animal proteins in order to lessen the thickening influence of "heavy proteins and fat." Apple cider vinegar supposedly thins the blood so it can circulate. more freely. Thick blood, they say, puts a strain on the heart and up goes the blood pressure. Another source states that the pectin present in apple cider vinegar works its way through the digestive system, binding to cholesterol and removing it from the body.

Apple cider vinegar is also available in tablet form. One brand is merchandised as a "digestive aid for vegetarians." The manufacturer of this product alleges that the tablets help acidify the stomach and help digest protein. Another tablet, which contains apple cider vinegar as one of its components, is sold as a fiber supplement and supposedly assists in weight loss. Still other companies add herbs to their apple cider vinegar "so people see relief from even more ailments."

The rubbery mass of goo called the mother of vinegar" is reputed to have magical healing properties as well. Nibbling on a bit of this moldy slime every day is purported to prevent most infectious diseases and keep germs and parasites from invading the body.

One company's advertisement for organic, raw, unfiltered, unheated, unpasteurized apple cider vinegar is particularly alarming. This company's ad maintains that "there is nothing in this wonderful natural apple cider vinegar that can in any way harm your body!" Apparently, they have never heard of the danger of E. coli 0157:H7 in unpasteurized fruit juices. Normally vinegar is too acidic to support bacteria. However, should the acidity weaken (pH reaching 4.6 or higher), then pathogens will survive and grow.

Jogging in a Jug

In 1985, Jack McWilliams, an Alabama farmer, concocted a potion he called "Jogging in a Jug." It consisted of apple cider vinegar combined with a variety of fruit juices to give it a more appealing taste.

Acetic acid, claimed McWilliams, was lacking in the modem diet, and this deficiency was the root cause of many health problems. He claimed that the potion had cured his arthritis and heart disease, and it could reduce the risk of cancer in the internal organs. McWilliams marketed his product through the media, receiving extensive coverage in small community newspapers and broadcast outlets. He reportedly sold $9 million worth of his potion in one year.

The FDA, however, did not look kindly on Mr. McWilliams's vinegar product and its advertised claims. The federal government seized the product in 1994 due to the unproven health claims.

In 1995, thousands of bottles of the potion were ordered destroyed because the product was considered an unapproved new drug due to the claims made by the producer. Subsequently, Mr. McWilliams's company, Third Option Laboratories, Inc., paid the Federal Trade Commission a $480,000 fine to settle charges of false advertising. "Jogging in a Jug" is still on the market today with a new label that meets FDA guidelines.

The Real Story

There is no scientific evidence that apple cider vinegar has any medicinal properties. While the folksy anecdotes from those who claim to have benefited from apple cider vinegar tonics may be amusing to read, they are simply that -- anecdotes.

Apple cider vinegar is anything but a storehouse of nutrients. A nutritional analysis of one tablespoon (more than the one or two teaspoons suggested to make a tonic) reveals that the golden liquid contains less than a ram of carbohydrate: minuscule amounts of calcium, iron, magnesium, sodium. copper, manganese, and phosphorus; and a mere 15 mg of potassium. The fiber, vitamin, and amino acid content is zero.

As for the presence of any beneficial enzymes in apple cider vinegar or the "mother," food scientists doubt that any could thrive in the acid environment of the vinegar. Assuming any were present, though, they would be destroyed in the acid of the stomach when consumed and be of no use to the body.
The Arthritis Foundation calls vinegar a harmless, but unproven, arthritis remedy. It points out that arthritis symptoms come and go, and that a person using an unproven remedy may think a remedy worked simply because they used it at a time when symptoms were going into natural remission. Such is undoubtedly the case for many of the "cures" connected to vinegar.
Beth Fontenot is a nutrition consultant and freelance nutrition writer in Lake Charles, LA. She serves on the adjunct faculty at both McNeese State University in Lake Charles and Lamar University in Qrange, TX.

Working women more likely to put on weight 'as they put office needs over their health'

2012-07-11T19:56:00.002-07:00

Scientists claimed career-driven women are inclined to foresake healthy home-cooked food and exercise less

By Daily Mail Reporter

Dr Au said: 'Longer work hours may reduce the time spent preparing home-cooked meals'

Women who work more than 35 hours every week are more likely to put on weight, according to a new scientific study.

Research found career-driven women are inclined to foresake healthy home-cooked food, exercise and sleeping for the office. As a result, many are at risk of piling on the pounds.

The study also found that women who work more than 49 hours a wek are much more likely to drink and smoke.

The findings were revealed in a study into how employment status and the number of hours worked affects weight.

The research, led by Dr Nicole Au, from the Centre for Health and Economics at Monash University, Melbourne, analysed 9,276 women aged 45-50 over two years.

Findings showed 55 per cent put on weight in that time - with the average women gaining 1.5 per cent of her initial weight.

Some were also reported to have experienced ‘extreme’ amounts of weight gain.

And those most likely to experience the problem were working more than 35 hours a week.

Dr Au put the findings down to women spending less time maintaining their health and fitness levels.

She said: 'This study highlights the increasing number of women entering the workforce and the effects on their ability to maintain a healthy weight.

'Longer work hours may reduce the time spent preparing home-cooked meals, exercising and sleeping which are risk factors for obesity.

'Policies that assist women who work long hours to reduce the time costs of sustaining a healthy diet and their physical activity routine may have positive benefits.'

The research, published in the International Journal of Obesity, also found women working more than 49 hours were more likely to smoke and drink alcohol.

As many as 65 per cent were drinking to ‘risky’ levels and 36 per cent did not do any form of exercise.

Lucy Green, an office manager from London, said she’d found herself losing control of her weight as a result of long working hours.

The 41-year-old said: 'I start work at 8am and don’t usually finish until 7pm.

'As a result, I’ve had to put my exercise regime on the back burner because I just don’t have the energy to go to the gym.

'Unfortunately, it’s really starting to take it’s toll on my figure.

'The office is always full of junk food like cakes and biscuits and I find myself eating them all too often.

'I’m putting on weight because I’m not taking time to work off the extra calories, so I’m going to have to make a special effort to start doing exercise again soon.'

Blood test for missing or damaged DNA could provide hint of a prostate cancer relapse

2012-05-09T20:29:00.001-07:00

By Sophie Borland

A blood test for men with prostate cancer could detect if the illness is likely to be life-threatening, claim scientists.
At present it is extremely difficult for doctors to know whether a patient’s tumour is slow-growing - and harmless - or if it is deadly.
This means that thousands of men have to endure agonising surgery, chemotherapy or radiotherapy to remove tumours that may never have caused a problem.

Breakthrough: Researchers believe they've found a blood test that can determine the likelihood of prostate cancer returning

Now American scientists think they have come up with a method of predicting how quickly the tumour will spread.

More...

It could also determine whether the tumour is likely to return after surgery - which would warrant the patient having additional chemotherapy or radiotherapy.
The method involves testing the blood for a genetic abnormality - called the copy number variation, or CNV - that determines how quickly the cancer will spread.
Researchers at the University of Pittsburgh in the U.S, looked at the blood samples and records of 238 prostate cancer patients over a period of ten years.
They compared the levels of CNV with how the disease had progressed, as established from their medical records.

Hard cell: The method involves testing the blood for a genetic abnormality - called the copy number variation, or CNV

The academics found that in 69 per cent of patients the CNV blood test was able to correctly predict how quickly the tumour was growing.
In 81 per cent of cases it was able to determine whether it would return after treatment.
The scientists - whose work is published in the American Journal of Pathology - also tested patients’ tissue close to the tumours for levels of CNV and this showed similar success rates.
It is likely to be several years before the academics are able to develop a blood test to predict the speed prostate cancer will spread.
But lead researcher Dr Jian-Hua Luo, from the University of Pittsburgh School of Medicine, said in future it could prove to be ‘a more efficient and accurate way to predict the behaviour of prostate cancer.
‘For a patient diagnosed with prostate cancer, CNV analysis done on blood or normal tissues would eliminate the need for additional invasive procedures to decide a treatment mode.
‘For a patient already having a radical prostatectomy (surgery), CNV analysis on the tumour or blood sample may help to decide whether additional treatment is warranted to prevent relapse.’
New figures last week showed that 40,000 men are now being diagnosed with prostate cancer every year.
This increase is mainly due to greater use of the Prostate Specific Antigen (PSA) test, which measures levels of a chemical that is high when tumours are present.
But although the test has been credited with detecting some deadly cancer cases earlier, there are concerns it often causes ‘false alarms’.
And this month another group of American researchers claimed that surgery to remove prostate cancer is often ineffective.
A study involving 731 patients found that those who had operations were only 3 per cent more likely still to be alive 12 years later compared to those who didn’t have treatment.

Persistent cough 'could be warning sign of lung cancer': Stars who lost relatives to disease launch awareness campaign

2012-05-09T20:26:00.001-07:00

By Claire Bates

Just one in 10 people realise that a persistent cough could be a key symptom of lung cancer, according to statistics released by the Government as it launches a campaign to raise awareness about the disease.
Despite the condition killing more people than any other form of cancer in England, very few people are aware a cough lasting three weeks is a sign of a potential sufferer.
An advertising drive backed by actor Ricky Gervais and TV presenter Jenny Frost will be launched tomorrow in a bid to raise awareness about the issue and improve earlier diagnosis in England.

Actor Ricky Gervais and singer Jenny Frost are both backing the Government's 'Be Clear on Cancer' campaign, after both lost a parent to lung cancer

It is hoped Be Clear on Cancer campaign will help save around 1,300 lives a year.
Health Minister Paul Burstow said: 'Lung cancer is the biggest cancer killer in this country but worryingly many people don't know the signs and symptoms that could save their lives.
'The earlier lung cancer is diagnosed, the better the chance of survival.
'The message from this campaign is simple; if you have a persistent cough for three weeks or more, visit your GP.'

More...

Pretty in pink: Eva Longoria is a class act with glossy hair and stylish knitted top

Lung cancer affects 33,000 people every year in England with the majority of cases occurring in people over the age of 55.
When diagnosed at its earliest stage, as many as 80 per cent of people are alive five years after diagnosis compared with only seven per cent diagnosed at a late stage.

Manchester United captain Sir Alex Ferguson lost both his mother and father to lung cancer, while Lynda Bellingham lost her sister

The campaign is being supported by a host of stars, many of whom have been touched personally by the disease. Manchester United captain Sir Alex Ferguson, 70, lost both parents to lung cancer.
He told the Manchester Evening News: 'My father was 66 when he died and my mother was only 64. Dad was diagnosed with lung cancer only a week after he retired and within 12 months it had killed him.
'Then my mum, who had smoked all her life, was diagnosed with lung cancer as well and she passed away a few years after my dad.'
Actor Ricky Gervais, who lost his mother to lung cancer when she was 74, said the condition was 'devastating'.
'It's a horrible, horrible disease,' he said.
Singer Jenny Frost cancelled her wedding in 2010 after her mother Rita succumbed to lung cancer.
Other celebrity supporters include actor Robert Powell, author Tony Parsons and actress Terry Dwyer who lost their fathers and Dragon Duncan Bannatyne who lost his mother. I'm A Celebrity star Stephanie Powers and writer Cassandra Jardine battled the disease themselves.

Campaign backers: Sir Alex Ferguson, Stephanie Powers, Tony Parsons and (bottom row) Linda Robson, Mark Lawrenson and Cassandra Jardine

The campaign follows an awareness-raising pilot in the Midlands in October last year. This showed improved knowledge of lung cancer and increased confidence in recognising the symptoms. There was a 23 per cent increase in attendance to primary care. Based on a sample of trusts, there was an increase in referrals for chest x rays and chest CT scans compared with the same period in the previous year.
Professor Sir Mike Richards, National Cancer Director for England, said: 'It is vital that cancer patients get treated quickly so they have the best chance of surviving. We have made early diagnosis central to our Cancer Outcomes Strategy.
'Earlier diagnosis of Lung Cancer combined with the best treatments could help save an additional 1,300 lives a year.'
Paula Chadwick, chief executive of the Roy Castle Lung Cancer Foundation, added: 'We really hope people will begin to associate a persistent cough as a symptom of lung cancer, the way they associate a lump as a symptom of breast or testicular cancer.'

Supporters: Ricky Gervais, Robert Powell, Nikesh Shukla, Lynda Bellingham with (bottom row left to right) Duncan Bannatyne,Tricia Penrose, Jenny Frost and Terri Dwyer

One in six cancers are caused by preventable infections

2012-05-09T20:15:00.000-07:00

By Daily Mail Reporter

Two types of the human papilloma virus (HPV) cause around 70 per cent of all cervical cancers

One in six cancers are caused by preventable infections, research shows.
Infections cause around two million cancer cases a year, with 80 per cent of these effecting the developing world.

Of 7.5 million cancer deaths worldwide in 2008, 1.5 million were down to treatable or preventable infections, reports the Lancet Oncology.

Catherine de Martel and Martyn Plummer from the International Agency for Research on Cancer in France said: 'Infections with certain viruses, bacteria, and parasites are one of the biggest and preventable causes of cancer worldwide.

'Application of existing public-health methods for infection prevention, such as vaccination, safer injection practice, or antimicrobial treatments, could have a substantial effect on future burden of cancer worldwide.'

For the study the team estimated the proportion of cancers that could be attributed to infection globally and in eight regions by calculating the population attributable fractions (PAF) - the proportion of new cancers in a population that could have been prevented by an intervention.

They calculated that around 16 per cent of all cancers worldwide in 2008 were infection-related, with the fraction of cancers related to infection about three times higher in developing than in developed countries.

The fraction of infection-related cancers varied widely between regions, from 3.3 per cent in Australia and New Zealand to 32.7 per cent in sub-Saharan Africa.

Dr de Martel said: 'Many infection-related cancers are preventable, particularly those associated with human papillomaviruses (HPV), Helicobacter pylori, and hepatitis B (HBV) and C viruses (HCV).'

Since September 2008 there has been a national programme to vaccinate girls aged 12 to 13 against the human papilloma virus

Cervical cancer accounted for around half of the infection-related burden of cancer in women, and in men liver and gastric cancers accounted for more than 80 per cent.

Dr de Martel concluded: 'The 2011 UN high-level meeting on non-communicable diseases highlighted the growing global agenda for prevention and control of non-communicable diseases.

'But although cancer is considered a major non-communicable disease, a sizable proportion of its causation is infectious and simple non-communicable disease paradigms will not be sufficient.'

In an accompanying Comment, Goodarz Danaei from Harvard School of Public Medicine, Boston, said: 'Their estimates show the potential for preventive and therapeutic programmes in less developed countries to significantly reduce the global burden of cancer and the vast disparities across regions and countries.

'Since effective and relatively low-cost vaccines for HPV and HBV are available, increasing coverage should be a priority for health systems in high-burden countries.'

Less Inflammatory Bowel Disease Seen in Southern Latitudes

2012-05-09T20:03:00.001-07:00

Women living in the southern latitudes of the United States have significantly lower rates of Inflammatory Bowel Disease (IBD) than those living in the country's northern regions, according to new research published online January 11, 2012, in Gut.
Similar trends have been reported in Europe in the past; however, this is the first study to evaluate the role of latitude on IBD incidence in the United States.
To investigate the issue, Hamed Khalili, MD, from the Division of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Boston, and colleagues evaluated data on 175,912 women enrolled in the Nurses' Health Study I (NHS) in 1976, and in the NHS II in 1989.
The data included information on the women's state of residence at birth, at age 15 years, and at age 30 years. The states were categorized as being in the northern, middle, or southern tiers of each of the 4 time zones (eastern, central, mountain, and pacific).
Follow-up data taken in 2003 identified 257 cases of Crohn's disease and 313 cases of ulcerative colitis among the women, with the incidence of each disease increasing significantly according to increased latitude (P _trend < .01).
The residence at age 30 years showed the strongest association with risk for Inflammatory Bowel Disease.
The multivariate-adjusted hazard ratio for women residing in southern latitudes compared with those residing at northern latitudes at age 30 years was 0.48 (95% confidence interval, 0.30 - 0.77) for Crohn's disease and 0.62 (95% confidence interval, 0.42 - 0.90) for ulcerative colitis. The multivariate analysis was adjusted for age, body mass index, ancestry (Southern European, Scandinavian, other white, nonwhite), smoking, and oral contraceptive and hormone therapy use.
"In two large prospective cohorts of US women, the incidence of [ulcerative colitis and Crohn's disease] was significantly lower among women who resided in the southern latitudes, particularly in later life (age 30 years), than in those residing in the northern latitudes," Dr. Khalili and colleagues write.
"These results were consistent even after accounting for differences in self-reported ancestry and smoking, suggesting that other environmental or lifestyle factors correlated with geographical variation may mediate these associations."
The authors hypothesize that the main explanation for the reductions in southern latitudes is related to greater levels of sun exposure and to the higher levels of plasma vitamin D that are associated with ultraviolet (UV) radiation.
"UV radiation is the greatest environmental determinant of plasma vitamin D and there is substantial experimental data supporting a role for vitamin D in the innate immunity and regulation of inflammatory response," the authors write.
"The role of vitamin D in the pathogenesis of IBD is further supported by the observation that animal models of colitis have more severe inflammation in vitamin D receptor knock out animals or animals deficient in 1,25(OH)₂ vitamin D."
In addition, UV radiation is associated with regulation of T cells, as well as the production of interleukin (IL) 4 and IL-10, and the inhibition of IL-12, which suppresses the inflammatory response, they note.
Bincy P. Abraham, MD, an assistant professor of medicine in the Inflammatory Bowel Disease Program at Baylor College of Medicine in Houston, Texas, said that vitamin D, or a lack thereof, has been recognized as a potential risk factor for IBD, but its role is not entirely understood.
"Theoretically, vitamin D can play a role in inflammation: low levels may contribute to inflammation, and thus can be explained by the general north–south gradient of inflammatory bowel disease we have seen historically in the US, as well as Europe," Dr. Abraham told Medscape Medical News.
"However, knowing the vitamin D levels in both groups of patients is important in order to clarify this," added Dr. Abraham, who was not involved in the study. "This is because there could be other confounders — other environmental causes that we do not know about."
In her own research on Inflammatory Bowel Disease, Dr. Abraham found high levels of abnormal bone density among patients with IBD and vitamin D deficiency, but that research was also inconclusive regarding the vitamin's influence.
"It was difficult for us to determine a correlation of IBD disease activity and vitamin D levels due to too many confounding variables," she said, noting that, among potential variables, there is even a theory that refrigeration of food may increase the risk for Inflammatory Bowel Disease.
"My general sense is that [a correlation with vitamin D] is quite possible," Dr. Abraham concludes. "We may need to do additional, larger-scale studies of vitamin D levels and their association in contributing to the development of Inflammatory Bowel Disease."
The study received support from the National Institutes of Health and the Broad Medical Research Program of the Broad Foundation. The authors included a clinical investigator for the Damon Runyon Cancer Research Foundation, and one author is supported by a career development award from the IBD Working Group and the Crohn's and Colitis Foundation of America. Dr. Abraham has disclosed no relevant financial relationships.

Fecal Calprotectin Helps Spot Pediatric Inflammatory Bowel Disease

2012-05-09T20:02:00.001-07:00

By David Douglas
NEW YORK (Reuters Health) Mar 16 - High fecal calprotectin (FC) levels identify children who need endoscopic exams for inflammatory bowel disease (IBD), UK researchers say.
FC is "far superior to commonly utilized blood parameters such as C-reactive protein and white cell count" as a marker of IBD, they reported online February 28th in The American Journal of Gastroenterology.
"This study robustly identifies fecal calprotectin as not only an important biomarker during the treatment of pediatric inflammatory bowel disease but also during the initial investigation of children with suspected disease," Iead author Dr. Paul Henderson told Reuters Health by email.
Dr. Henderson of the University of Edinburgh and colleagues reviewed data on 190 volunteers who had FC testing, including 91 with IBD and 99 controls.
In their own practice, the researchers use a cutoff of 200 mcg/g to define high levels.
In the study, the median FC at diagnosis in the IBD group was 1,265 mcg/g, compared to only 65 mcg/g in controls. In the patient group, values were similar whether with Crohn's disease, ulcerative colitis and unclassified Inflammatory Bowel Disease.
"Our work demonstrates that disease location and type do not influence FC at diagnosis and that FC performs far better than commonly used blood tests," Dr. Henderson said.
Senior author Dr. David C. Wilson added, "(FC) has indeed become our standard of care -- although no single test will be 100% correct in diagnostic terms, it is much superior to any (or a combination of all) commonly used blood 'inflammatory markers.'"
"A negative test is very helpful," he said, "and reduces the number of children in our practice going to invasive testing with GI endoscopy and biopsies; by contrast, a test showing more than 200 mcg/g strengthens our suspicion of Inflammatory Bowel Disease and will expedite further investigation, unless the clinical scenario has markedly improved."
Further studies are now required, but Dr. Wilson pointed out that "because it has become our standard of care, we are not placed to perform the definitive trial with blinded calprotectin usage and evaluation of suspected gut inflammation of children and young people generating robust data on reduction (or not) or need for GI endoscopy and biopsies."
In the meantime, he and his colleagues predict, someday "the routine use of FC in the pediatric setting should significantly enhance our ability to more accurately screen children for Inflammatory Bowel Disease."

Patients With IBD Fare Well on Their Travels

2012-05-09T20:00:00.001-07:00

Patients with inflammatory bowel disease (IBD) who traveled to developed countries had a higher rate of illness compared with other travelers, but the rate of illness was the same for travel to developing or tropical regions. Most travel-related illnesses among the patients with IBD arose from sporadic flares of their disease, rather than increased susceptibility to enteric infections, suggested study authors Shomron Ben-Horin, MD, director of the IBD service, and coauthors from the Sheba Medical Center and Sackler School of Medicine of Tel-Aviv University in Tel Hashomer, Israel.
The research was published online November 3 and in the February print issue of Clinical Gastroenterology and Hepatology.
Compared with healthy control patients, the absolute increased risk for patients with IBD was small, and most episodes of illness that they experienced were mild, providing reassurance for many patients who want to travel.
Patients with IBD have often been advised to avoid travel, especially to developing countries, for fear of contracting infections or experiencing disease flares in regions with poor hygiene or potentially inadequate medical facilities. Self-imposed or physician-advised restrictions on travel can severely limit patients' quality of life or opportunities to do business abroad.
Because little data exist on the risk of travel for patients with Inflammatory Bowel Disease, the investigators performed a retrospective, case–control study comparing illnesses among patients with Inflammatory Bowel Disease (n = 222; 523 trips) and healthy control individuals (n = 224; 576 trips), using validated, structured questionnaires, interviews, and chart reviews. The questionnaires included items related to demographics, medical history (eg, travel clinic attendance, immunizations, and prophylactic and regular medications), details of all travel going back 5 years, and any illness during or within 3 months after any trips. The authors used the United Nations Human Developmental Index classification to identify developing and developed countries.
Individuals in the case group included individuals attending outpatient gastroenterology (GI) clinics at the medical center. Individuals in the control group included volunteers without known Inflammatory Bowel Disease who were drawn from hospital staff, their family members, and people escorting relatives undergoing endoscopies. The mean age of both groups was 37 years. Individuals in the control group received the same questionnaire as patients with IBD, but without IBD-specific items. The authors defined illness as any GI or non-GI episode.
Patients with Inflammatory Bowel Disease experienced illness in 15.1% of their trips compared with 10.9% of trips made by control patients (odds ratio [OR], 1.44; 95% confidence interval [CI], 1.01 - 2.0; P = .04). For both patients with IBD and control participants, enteric disease accounted for 92% of the episodes, most of which were mild to moderate and resolved within a few days, the authors report. Only 5 patients with IBD and 4 control participants required hospital admission for any reason while traveling.
Travel to developed countries accounted for most of the difference in illness between patients with IBD and control participants. For the 2 groups, the rates of illness were the same when they went to developing regions (17% vs 21% of trips, respectively; P = .24).
Their rates of illness when traveling to developing countries (17% of trips) was not statistically different from when they went to developed countries (13.9% of trips; P = .32). They did, however, experience an almost 2-fold increased risk when traveling to the tropics compared with developed countries (OR, 1.9; 95% CI, 1.1 - 3.3; P = .02).
Control individuals experienced much less illness in developed countries (3.3% of trips) compared with travel in developing regions (21.4% of trips; OR, 6.6; 95% CI, 3.2 - 12.2; P < .001). When they went to the tropics, however, their rates of illness increased 10-fold compared with travel in developed countries (33.3% vs 3%, respectively; OR, 13.6%; 95% CI, 6.7 - 27.6; P < .001) and were not statistically different from the rate of illness for patients with IBD (P = .18).
Factors Influencing Travel-Related Risk
It appeared that underlying IBD activity was an important determinant of travel-related disease activity. Multivariate analysis showed that risk increased if patients experienced frequent flares (OR, 1.9; 95% CI, 1.1 - 3.4; P = .02) or had prior IBD-related hospitalizations (OR, 3.5; 95% CI, 1.3 - 9.3; P = .01). Among patients with IBD, disease remission for at least 3 months before traveling reduced the risk for travel-related illness by 70% (OR, 0.3; 95% CI, 0.16 - 0.5; P < .001). Patients in remission had the same risk for illness during travel as did individuals in the control group (12% vs 10.9%; P = .5).
In the multivariate analysis, there was no independent effect of the use of immunomodulatory drugs during the trip on the risk for illness during travel (P = .5).
Because the length of the trip may affect the likelihood of illness, the investigators normalized the results per 10 days of travel and found a 7% risk per 10 days for individuals in the case group vs 5% per 10 days for individuals in the control group (OR, 1.4; 95% CI, 1.01 - 1.96; P = .04). When stratified by trip duration, there was no increased risk for patients with IBD traveling to developing or tropic areas, in line with the nonnormalized analyses.
Travelers with IBD experienced disease flares within 3 months of returning to Israel after 16% of their trips. The incidence of flares was higher if travelers had experienced an episode of illness during the trip than for uneventful trips (43% vs 11.6%, respectively; OR, 7.4; 95% CI, 4.2 - 12.9; P < .001). The authors note that almost half of the patients with illness during the trip and flares afterward felt that the flare was a direct continuation of the episode during the trip.
The authors caution that the retrospective nature of the study makes it susceptible to recall bias, and they emphasize that it was not sufficiently powered to detect differences in rare opportunistic infections that may affect immunocompromised patients. They also warned that live attenuated vaccines such as those against yellow fever are contraindicated in such patients. Another limitation of the study is that it involved travelers from a single, developed country, and therefore the results may not be generalizable to travelers with IBD from other developed or developing countries.
Charles Ericsson, MD, professor of medicine, head of clinical infectious diseases, and director of the travel medicine clinic at the University of Texas Medical School at Houston; founding editor-in-chief of the Journal of Travel Medicine; and past-president of the International Society of Travel Medicine, told Medscape Medical News that the study is retrospective, albeit case-controlled, "so that immediately calls into question recall bias when you're asking people to remember trips up to 5 years later. I'm taking any of the data with a bit of a grain of salt." He said most of the illnesses were reportedly mild, but people tend especially to remember more severe illnesses.
"The data are OK as far as they go, but I think you're left with enough uncertainties that I will refuse to use data like this to say that I'm not going to worry about somebody with IBD when they travel to a developing country" and not offer them chemoprophylaxis against travelers' diarrhea, Dr. Ericsson said. Even if the incidence is not different from control participants, "when they do get travelers' diarrhea, I think the impact on the subject is profound because they don't know whether it's a flare of their IBD" that requires treatment or not, "and I'd rather prevent that conundrum to begin with." He admits he's "a fan of chemoprophylaxis" in general, offering rifaximin to his high-risk travelers, which is active in the upper GI tract, and therefore a good prophylactic agent.
Another issue "that does bug me a little bit is the outcome measurement [of] any illness," he said. He would have preferred the authors to distinguish enteric conditions from other types of illness. "They allude to the fact that...92% of the outcomes were enteric disease," he noted. "Then why not just study that 92%, to keep it clean? You would have a study that would have focused on the most important issue."
Dr. Ericsson also wondered about the meaning of the finding that the patients with IBD experienced more illness when they went to developed countries compared with control patients (P < .001), but not when they visited developing ones (P = .2). "What they didn't control for is the likelihood, I would think, that anybody traveling from a developed to another developed country may well not have been on a vacation but, rather, traveling for business, and was stressed out, and that's a known precipitator for a flare of your IBD," he noted. And he speculated that "the IBD people in fact are concerned about going to a developing country and take extra precautions," such as chemoprophylaxis or watching out for food and beverages.
The finding that people with IBD had such a high level of problems in developed countries, but not in developing ones, implies that they experienced only a very small level of travelers' diarrhea in developing countries. "It doesn't sit well with me," Dr. Ericsson said. "I'm not quite sure how to interpret it. I'm worried that there's confounding issues going on of behavioral differences that were not assessed."
Also, with a reported mean trip length of 22 days for both patients with IBD and control participants, he found the incidence of illness quite low compared with previous reports of travelers' diarrhea, depending on trip length. The specific countries, areas of the countries, and purposes of the trips may have affected the outcomes.
In summary, Dr. Ericsson said the study is valid as it is presented, but "it's the interpretation of it that has to be taken with a bit of a grain of salt." He said the findings may lead him to advise a patient with IBD who has had many flares to find out where to get treatment while traveling, as their risk for illness is increased.
He said that going forward, he would like to see a properly designed prospective case–control study implemented that looks at a sufficient number of patients with IBD as they travel, which may avoid some of the problems of recall bias during such a long period of a retrospective study as this one.
Dr. Ben-Horin has received consultancy fees from Schering-Plough and Abbott Laboratories. The other authors and Dr. Ericsson have disclosed no relevant financial relationships.

Fecal Calprotectin Helps Spot Pediatric IBD

2012-05-09T19:59:00.001-07:00

Youths With IBD May Need Large Doses of Vitamin D

2012-05-09T19:58:00.001-07:00

By Megan Brooks
NEW YORK (Reuters Health) Apr 17 - In children and adolescents with inflammatory bowel disease (IBD) and insufficient serum vitamin D levels, taking 2,000 IU of vitamin D3 every day for six weeks, or a 50,000-IU dose of vitamin D2 every week, were both more effective at raising serum 25OHD concentration than 2,000 IU/day of vitamin D2.
Dr. Helen Pappa from Children's Hospital Boston, who worked on the study, told Reuters Health: "This is the first study to compare efficacy of three widely used vitamin D repletion regimens in children with vitamin D insufficiency. Findings from the study suggest that large vitamin D doses are needed to treat vitamin D insufficiency in this population, and that body weight rather than absorption affects regimen success in this population."
Based on the results of this study, "doses of 2,000 IU of vitamin D2 per day for six weeks should not be used because they may be inadequate in treating vitamin D insufficiency in adolescents with IBD," she said.
Vitamin D insufficiency (25OHD <20 ng/mL) is common in children with IBD and its treatment has not been studied, Dr. Pappa and colleagues said in a report online March 28 in the Journal of Clinical Endocrinology and Metabolism.
They enrolled in their study 71 patients with Inflammatory Bowel Disease between 5 and 21 years old and serum 25OHD <20 ng/ml.
All participants took oral elemental calcium (1,200 mg for those aged 11 or older and 800 mg for those younger than age 11) plus one of three vitamin D regimens: 2,000 IU vitamin D2 daily (study arm A; control), 2,000 IU vitamin D3 daily (arm B) and 50,000 IU vitamin D2 once weekly (arm C).
Sixty-one subjects completed the trial and two withdrew due to adverse events. All regimens were well tolerated, the researchers say. Adverse events occurred in one third of subjects overall, with no differences between the three arms. Most common were nausea (n=6), increased thirst and loss of appetite (n=5 each) and pruritus (n=4),
After six weeks of treatment, the mean changes from baseline in serum 25OHD were 9.3, 16.4 and 25.4 ng/mL in arms A, B and C, respectively.
Arms B and C experienced statistically significantly greater mean changes than arm A (Bonferroni adjusted p=0.03 and p=0.0004, respectively). "Serum 25OHD concentration increased on average by 130% and 190% in arms B and C, respectively, compared with just 62% in arm A," the researchers report.
Both arms B and C were 95% successful in raising serum 25OHD levels above 20 ng/mL; however, 62% of subjects in arm B and 25% in arm C did achieve a serum 25OHD level above 32 ng/mL, the investigators report. They estimate that a cumulative dose of 400,000 IU of vitamin D2 or 220,000 IU of vitamin D3 "would be sufficient to achieve this level."
The researchers say further studies are needed to "define a specific target serum 25OHD concentration and the best regimen by which to achieve and maintain this in young patients with Inflammatory Bowel Disease."
They also found that subjects who failed treatment were heavier, which supports weight-adjusted vitamin D dosing.
No change in serum parathyroid hormone (PTH) concentration was observed in any of the treatment arms. The authors note that baseline PTH levels were lower than reference PTH values for healthy children of similar age in their geographic region.
"PTH response to treatment was blunted suggesting a relative hypoparathyroidism in this population," Dr. Pappa said. None of the study subjects experienced hypercalcemia, hyperphosphatemia, or serum 25OHD concentration above 68 ng/mL after treatment.

Stress levels and smoking: Why your dad's bad habits may have wrecked your genes

2012-05-02T18:17:00.001-07:00

By John Naish

For years, scientists and doctors have blamed illnesses on our parents, showing how conditions such as blindness and deafness can be passed down genetically, and bad lifestyle habits can put babies at risk of heart defects.

But medicine is increasingly pointing the finger specifically at fathers, with studies showing how male genes and even men’s diets and stress levels can create serious health problems for their offspring, including diabetes, depression and obesity.

This latest finding is part of a larger picture where scientists are starting to discover diseases passed from man to boy through the Y chromosome

It seems that the Bible warning holds true for health: the sins of the fathers really do plague their children — and this effect may pass on to their grandchildren, too.

The latest evidence in this newly emerging jigsaw comes from research that shows a common genetic flaw may increase a son’s risk of heart disease by 50 per cent.

Scientists at Leicester University who analysed samples from more than 3,000 men found that those with a common group of genetic traits (called haplogroup I) had a 50 per cent higher risk of coronary artery disease than men in other genetic groups.

This genetic flaw is at the centre of male genetic identity; it’s carried in the Y chromosome, responsible for determining that babies are born as boys (chromosomes are found in all cells and carry our genetic blueprint) — so it’s passed only from fathers to sons.

It is thought that as yet unidentified genetic flaws in men’s immune systems may cause chronic inflammation in their arteries, which can lead to heart disease.

The British Heart Foundation, which funded the study, said the findings could lead to new tests and treatments for coronary problems.

And while men can’t change their genes, they could benefit from learning if they have inherited this danger, says research scientist Lisa Bloomer, one of the study’s authors.

Indeed, while there are no tests for this haplogroup yet, if your father and uncles have had heart troubles, it is sensible to assume there is a strong chance you may be affected.

‘You can reduce your risk if you mitigate the effects of other dangers, such as your weight, blood pressure and cholesterol levels,’ says Ms Bloomer.

This latest finding is part of a larger picture where scientists are starting to discover diseases passed from man to boy through the Y chromosome.

‘It has already been found genes on this chromosome can increase people’s risk of being born with autism and for contracting HIV,’ says Ms Bloomer.

‘We need to do more work to understand how these problems occur.’

Men can pass on addictive behaviours and stress-related depression

Scientists are also learning how the bad effects of men’s lifestyle habits, such as their diet, stress levels, weight and smoking, can be transmitted through the genes in their sperm.

Just as disturbingly, it seems that men can pass on addictive behaviours and stress-related depression.

Here, it is not only sons who are affected but daughters, too, because these problems are passed on through genes that are not on the Y sex chromosome.

Early clues to this have been found by Washington University researchers who studied the sperm of a group of male heroin addicts.

The men’s sperm contained genes that had been changed from normal and would affect the development of any children they had.

These changes are called ‘epigenetic’ — alterations to a person’s genes that are caused by their lifestyle habits.

Significantly, the researchers found epigenetic changes that boosted the activity of OPRM1, a gene that controls how the body responds to its own heroin-like feel-good hormones.

This change is believed to be a factor in making people more liable to develop addictions.

In a similar fashion, men may transmit stress-related diseases across generations.

Scientists at New York’s Mount Sinai School of Medicine say lab experiments on rats have found epigenetic changes in the semen of males who show signs of stress and anxiety after being isolated or threatened.

Their studies show that baby rats sired by these fathers show an increased vulnerability to stress, and become anxious and depressed more quickly than normal. They also have higher levels of stress hormones.

This is despite the fact that their mothers showed no such problems, according to the study published in the journal Biological Psychiatry.

This may offer one explanation as to why depression can run in families.

Even smoking when very young can affect men’s sperm — and surprisingly, this may make their sons prone to becoming overweight.

The discovery was made using survey results from the Avon Longitudinal Study of Parents and Children — an investigation into the health of 14,000 mothers and their children in the Bristol area.

It began in 1991 and is the most comprehensive study of its kind.

Professor Marcus Pembrey, a clinical geneticist at the Institute of Child Health in London, found men who smoked before puberty had sons who were fatter by the age of nine, even when other lifestyle factors were taken into account. There was no similar effect among women.

‘It seems that before puberty, our genes are tuned to suit the environment we are living in. It is these genetic changes that are passed down the male line,’ says Professor Pembrey.

Perhaps the most important factor in determining a man’s legacy to his children comes from his dietary habits.

This takes us into a newly emerging field of science called nutri- epigenomics — the study of how food can alter our genes.

‘Rather than “you are what you eat”, this science shows “you are what your dad ate”,’ says Anne Ferguson-Smith, professor of developmental genetics at Cambridge University.

She points to research that showed fathers who eat high-fat diets and are obese tend to have daughters with a high risk of developing diabetes.

These girls are born with low insulin levels and glucose intolerance — classic signs of the disease.

The research, published in the journal Nature, concluded that the problems seem to be transmitted through the father’s sperm.

Professor Ferguson-Smith warns in the journal Cell Metabolism that these studies show the problem of ill-health being passed from parents to children ‘is not only just maternal territory.

The father’s nutritional and metabolic status merits attention, too, if we are to optimise the health of his children and grandchildren’.

Parents must understand that having healthy offspring is a joint enterprise if their babies are to inherit healthy genes.

This is most starkly illustrated by a study that found obese mothers produced sons at risk of being morbidly overweight.

These boys grew up to father daughters who, in turn, had an inherited tendency to be perilously overweight.

The Biblical prediction turns out to be more complex than anyone thought: the lifestyle sins of both parents can be visited on their children and are passed on in ways we are only beginning to understand.

How garlic can prevent a dicky tummy: Ingredient '100 times more powerful at fighting food poisoning than antibiotics'

2012-05-02T18:13:00.001-07:00

By Daily Mail Reporter

Garlic: A powerful natural anti-bacterial

A key ingredient in garlic is 100 times more powerful than two popular antibiotics at fighting a leading cause of food poisoning, scientists have found.

Tests discovered that the compound, diallyl sulphide, can easily breach a slimy protective biofilm employed by the bug to make it harder to destroy.

Not only is it a lot more powerful than antibiotics erythromycin and ciprofloxacin, it also takes a fraction of the time to work.

The discovery, published in the Journal of Antimicrobial Chemotherapy, could open the door to new treatments for raw and processed meats, and food preparation surfaces, that would reduce the toll of Campylobacter food poisoning.

Dr Michael Konkel, from Washington State University, said: 'This work is very exciting because it shows this compound has the potential to reduce disease- causing bacteria in the environment and in our food supply.

More...

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'Campylobacter is the most common bacterial cause of food-borne illness in the United States and probably the world.'

Symptoms of the infection include diarrhoea, cramping, abdominal pain and fever.

The bacteria also triggers nearly a third of cases of a rare paralysing disorder called Guillain-Barre syndrome.

Campylobacter infection symptoms include diarrhoea, cramping, abdominal pain and fever

Most Campylobacter infections stem from eating raw or undercooked poultry or foods that have been cross-contaminated via dirty surfaces and utensils.

It is the most common cause of food poisoning in the UK, according to the Food Standards Agency, and was responsible for 88 deaths in England and Wales in 2009.

Popular diabetes drug 'could make anti-depressants more effective'

2012-05-02T18:10:00.001-07:00

Anti-depressant citalopram was found to be more effective when used in conjunction with a popular diabetes pill

A popular diabetes drug used by almost a quarter of a million Britons could also treat depression, say scientists.
Actos, the brand name for pioglitazone, boosts the effects of antidepressants in patients whether they have diabetes or not according to new research.
Professor Shahin Akhondzadeh and colleagues treated 40 patients with moderate to severe depression with a common antidepressant, citalopram, either by itself or in conjunction with pioglitazone.
Over six weeks of treatment those who were also given pioglitazone reported lower symptoms of depression.
The preliminary study published online in Neuropsychopharmacology will need to be repeated using a larger group of patients, but the researchers say it has implications for how diabetes drugs which act in a similar way as Actos (pioglitazone) could be used to boost the effectiveness of currently available antidepressants.
A large proportion of patients treated with available antidepressant drugs fail to respond to medication.

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Prof Akhondzadeh, of Tehran University of Medical Sciences in Iran, said: 'Despite the advent of several antidepressant medications, the treatment of major depressive disorder (MDD) is still far from optimal.
'A large proportion of patients with MDD do not respond to their first medication. To achieve favourable response, these patients are generally treated by either switching to another treatment or with augmentation therapy.
'Recently, combination therapy from the beginning of treatment has been suggested to achieve higher responses and remission rates.'

Actos is currently used to help to control blood sugar levels in people with type 2 diabetes

Actos was licensed in 2000 and helps to control blood sugar levels. It belongs to a class of drugs called thiazolidinediones which are widely used for the treatment of type 2 diabetes.
Prof Akhondzadeh said: 'To the best of our knowledge, this was the first randomised controlled trial that evaluated the role of pioglitazone in patients with MDD without any significant metabolic problems.
'Our study showed pioglitazone is an effective and safe adjunct to citalopram in patients with moderate-to-severe MDD.
'In particular pioglitazone is associated with high rate of early improvement - and thus response and remission - which makes this drug a potentially useful augmentative strategy in patients with moderate-to-severe MDD.'

Teenager, 19, who thought her watery eye was caused by make-up discovers it is CANCER tumour behind her nose

2012-05-02T18:07:00.002-07:00

By Chris Parsons

When Tasha Jilka began suffering from a watery left eye, she put the strange symptom down to her make-up or the seasonal weather.

But far from being an innocuous allergic reaction to cosmetics, the teenager's bizarre ailment was one which changed her life forever, as she was later diagnosed with cancer.

The 19-year-old's watery eye was caused by a rare cancer tumour called olfactory neuroblastoma at the back of her nose which left doctors eventually having to rebuild her whole face.

Rebuilding her life: Tasha Jilka has had extensive surgery to rebuild her face following the shock discovery of a cancer tumour behind her nose

Tasha's rare diagnosis was eventually made a year after she first suffered the watery eye, having been missed by doctors and opticians.
Her ordeal began in May 2008, when, aged 16, her symptoms began.

WHAT IS OLFACTORY NEUROBLASTOMA?

Also known as esthesioneuroblastoma, it is a very rare, malignant tumour that develops in the nose.
The tumors are believed to start in the olfactory nerve, which transmits impulses related to smell from the nose to the brain.
Tumours can be slow-growing or aggressive. The condition is not thought to be inherited and the cause is unknown.
Common symptoms include a nasal obstruction, changes in sesnse of smell, facial pain, watery eyes and changes in vision.
Around 1,200 cases have been diagnosed since the condition was first identified in 1924. It appears to affect both genders and all races equally.
Treatments include surgery, radiation therapy, and possibly chemotherapy.
Five year survival following treatment ranges from 40 to 80 per cent, depending on the stage and grade of the tumour.

Source: hopkinsmedicine.org

Tasha, from Leicester, said: 'My left eye was very watery but I just put it down to make-up. It kept getting worse and I decided to go to my GP.

'It was put down to a cold and the weather and I was told it would go by itself.

More...

'I went back a few times when it didn’t get better and was referred to an optician, but they couldn’t find anything either.'
Four months later, her eye had got worse and she was referred to a Cambridgeshire hospital, as she was living near there at the time.
Tasha had an operation to clear a blocked tear duct - but it still did not solve her problems.
In 2009, when she and her family moved to Leicester, she again went to her doctor and was referred to specialists at Leicester Royal Infirmary.
Tasha said: 'I had a similar eye test but this time doctors also looked up my nose and could see a lump.'
A biopsy was taken and a short time later, Tasha’s cancer was diagnosed.
She said: 'When I was told it was as if they were talking about someone else. I knew it was serious.
'I thought it was a little lump in my face but the news began to sink in.'
In May 2010 Tasha had surgery to remove the tumour.
It was so severe that surgeons had to reconstruct her nose and she is still having problems with the vision in one eye.

Rare: Olfactory neuroblastoma is a form of cancer which affects the superior recess of the nasal cavity (stock picture)

She has had two major operations, one to remove the tumour and a second to rebuild her nose.
It has also meant the shape of her face has changed.
Tasha said: 'I am very strong and I am pulling through, but it is very hard.
'I feel if I had been diagnosed earlier and known more about the symptoms, I might not have had to have two such major operations.
'I have lost a lot of feeling in my face and my sense of smell.'
Tasha is now backing a campaign by charity the Teenage Cancer Trust to raise awareness of cancer in young people.

Pass the ice cream: Fat people can be as healthy as thin people (as long as they exercise)

2012-04-18T18:56:00.002-07:00

By Amy Oliver

For those who can't resist a second biscuit with their cup of tea, there's good news.

Fat people can be as healthy as thin people as long as they lead a healthy lifestyle, a study has shown.

Eric M Matheson and a team of doctors from the Medical University of South Carolina, tracked the BMIs of 12,000 people over 14 years.

Results: Doctors found that obese people who took part in 'healthy activities' carried roughly the same risk of dying young as their thinner counterparts

They found that obese people who took part in 'healthy activities' like eating five or more fruits and vegetables daily, exercising regularly, consuming alcohol in moderation, and not smoking, carried roughly the same risk of dying young as their thinner counterparts.

The obese people who did not have a healthy lifestyle were most at risk, the study published in the Journal of the American Board of Family Medicine, concluded.

More...

Lisa Wade, an Assistant Professor of Sociology at Occidental College, Los Angeles, wrote on The Society Pages, the study showed that 'thinness is protective if people are doing absolutely nothing to enhance their health.'

Graph: The 'hazard ratio' on the Y axis shows the risk of dying young, with one being the baseline, while the 'habits' on the X axis shows the number of healthy habits a respondent had

She added: 'Overweight and obese people can have the same mortality risk as "normal" weight people; therefore, we should reject the idea that fat people are “killing themselves” with their extra pounds. It’s simply not true.'

Dr Matheson examined the association between healthy lifestyle habits and mortality in a sample of 11,761 men and women with BMIs ranging from normal weight to obese.

The purpose of the study was to find an association between healthy lifestyle habits and mortality with a wide range of BMIs.

Why control pants can give you panic attacks... and the other hazards of too-tight clothes

2012-04-18T18:51:00.003-07:00

By Matthew Barbour

Wearing clothes that are too small for you doesn’t just look unsightly — as MATTHEW BARBOUR reveals, they can trigger all sorts of health problems.

CONTROL PANTS

RISKS: Stress incontinence, heartburn, hyperventilation, panic attacks.

Big squeeze: TV's Denise Welch in control pants

Many women swear by control pants, which hold your stomach in to make it look flatter. But tummy-taming underwear could also cause some unexpected — and unpleasant — side-effects.

‘Control underwear is the 21st-century version of the corset, with all the same health risks,’ says Richard Bricknell, director at the Bristol Physiotherapy Clinic.

The increased pressure on your lower stomach can force acid up to the gullet, leading to heartburn. Over time, this could contribute to inflammation, ulcers and, in extreme cases, oesophageal cancer.

Meanwhile, by artificially holding in your stomach, control pants prevent your diaphragm from descending fully while breathing, which can lead to hyperventillation, panic attacks and stress incontinence.

‘If there’s pressure on your stomach and you sneeze or cough, that pressure is forced down and not out, and could lead to an embarrassing leak,’ he says.

More...

‘Conditions such as reflux and irritable bowel syndrome can also worsen because of tight pants. Worn day in, day out, there could be very real health risks.’

TIGHT TROUSERS

RISKS: Nerve pain in the leg, heartburn, aggravated hernia.

Tight fit: Wearing skinny jeans like Carol Vorderman can cause nerve pain in the leg

Trendy skinny jeans could, in fact, leave you hobbling. Research published in the Canadian Medical Association Journal reported that figure-hugging trousers significantly increased the risk of the condition meralgia paresthetica, compression of the nerve running from the pelvis into the outer thigh.

This results in sensations of tingling, numbness and burning. But women who switched from skinny jeans to looser clothing found their symptoms disappeared after four to six weeks.

Meanwhile, overweight men who squeeze into tight trousers might aggravate an otherwise silent abdominal hernia, warns Dr Octavio Bessa, a gastroenterologist at Stanford University.

Writing in the Journal of the American Medical Association, he said 80 per cent of patients who presented with abdominal pain and heartburn after meals wore trousers at least 3in smaller than their waist.

A belt or waistband should sit just above the hips, he says, so trousers can ‘hang’ without placing pressure on the abdomen.

TIES AND COLLARS

RISKS: Glaucoma, headaches, dizziness, shoulder pain.

211%
The annual increase in sales of control pants in one High Street store

Shirts with constricting collars and over-tight ties can increase the risk of serious eye disease, according to a study in the British Journal of Ophthalmology.

They put pressure on the jugular vein in the neck, in turn raising the internal pressure of the eye, causing it to bulge. Increased pressure is one of the primary causes of glaucoma, a sight-threatening disorder affecting thousands of Britons.

Seven in ten men buy dress shirts with a collar size too small for them, according to a Cornell University study, suggesting they may be refusing to accept middle-aged spread.

This can restrict blood flow to the brain through the carotid arteries, leading to headaches, blurred vision and dizziness, as well as increasing tension in the back and shoulders.

SHOES

RISKS: Fungal foot infections, bunions, hammer toes.

High risk: Victoria Beckham's love of heels has given her back problems and bunions

British women now spend more than £30 million a year fixing medical problems such as bunions, corns, and trapped nerves caused by ill-fitting shoes.

Bunions run in families, but they are often triggered by ‘years of squashing feet into tight shoes and can be excruciatingly painful if left untreated,’ says podiatrist Simon Costain, of the Centre for Gait and Posture in London.

Meanwhile, cramping your toes in shoes that are too small is the main cause of hammer toe, a deformity caused by bending the toe joints out of shape so they curl up instead of lying flat.

And athlete’s foot, a fungal infection, can affect anyone who wears tight shoes for long periods due to insufficient airflow around the feet. The retained heat and moisture provide the perfect conditions for the fungi to thrive in.

‘Any tight shoes can lead to blisters, corns and calluses, ingrown toenails and swollen ankles, forcing fluid out of the feet into the ankles where it pools,’ adds Costain.

Swollen ankles can also be caused by tight socks, belts, bras or even rings, he says.

‘The lymph system is like a river, and any dam placed at any point in the river stops the flow to points below the dam.’

Tight shoes are particularly bad for diabetics, who are at serious risk of foot problems such as ulcers, which, if become infected, can require amputation of the leg.

UNDERWEAR

RISKS: Cystitis, fungal infections, male infertility.

Wrong thong: Ill-fitting underwear can cause numerous health problems (posed by model)

Having a visible panty line isn’t just a fashion faux pas — it could also cause a nasty yeast infection, cautions Dr Geeta Nargund, senior consultant gynaecologist and lead for reproductive medicine services at St George’s University Hospital in London.

‘Tight knickers of any style, particularly those made of synthetic materials which don’t allow air and moisture to circulate, can cause thrush and a range of other itchy skin conditions.

‘Thong-style knickers can also transfer bacteria forwards, leading to infections such as cystitis.

Bacteria thrive in the warm, moist environment created by tight pants — nylon and other synthetic materials are particularly bad, but even tight cotton can cause problems,’ she says.

‘The risk of infections is particularly high with women with lower oestrogen levels who have gone through, or are going through, the menopause.’

Tissues in this area need normal oestrogen levels to remain moist and healthy and protect against bacteria.

‘For these women, wearing tight underwear should be avoided at all costs.’

She adds that men are at risk, too, as figure-hugging underpants can cause infertility and damage to the testicles. ‘Testicles hang in the scrotum to keep cool — they need to be 2.2c cooler than the core body temperature,’ explains Dr Nargund.

‘If men wear tight underwear or trousers, the testicles become too hot, so testosterone and sperm production decrease — a common reason for male infertility.

‘If a couple are having infertility problems, one of the first things I suggest is the man switching to loose-fitting boxer shorts.’

Simon Costain adds a common and often missed cause of ankle and leg swelling in men is tight pants, because they prevent the natural flow of lymph fluid.

BRAS

RISKS: Back and shoulder pain, breathing problems.

The current method of bra measuring is outdated, researchers at the University of Portsmouth claimed last month.

Most stores measure under the bust and then around the fullest part, to get a back and cup size. But the technique, formulated in the Thirties, was only designed to go up to a D-size cup, while more than half of British women now have a cup size of E or greater.

If the cup or back size isn’t correct, the weight of the breasts goes straight to the shoulders rather than spread through the back evenly, explains chiropractor Rachael Lancaster, from the Freedom Back Clinics in Leeds.

‘I regularly see women with large breasts and severe mid-back pain because their bras don’t provide enough support. Combined with bad posture and sitting at a desk for hours on end, the spine is pulled out of alignment.’

But it’s not just big-busted ladies who are suffering.

‘Increasingly, I’m seeing small-breasted women who have back pain because they wear poorly-fitting gel-filled bras, which are designed to create the illusion of larger breasts,’ says Lancaster. ‘The weight of the bra puts extra pressure on the back.’

Meanwhile, push-up bras may restrict movement of the collar bone and upper ribs, which can lead to pain, breathing problems and even muscle wastage.

‘Getting a proper bra fitting is paramount,’ says Lancaster.

The Portsmouth researchers said women should take the five-step ‘best fit’ approach: trying the same bra in a number of sizes; assessing the length of the straps; the shape of the underwire; how well the back and cups fit; and whether the front band is in contact with the breastbone.

Secrets of an A-list body: How to get thighs like David Beckham's

2012-04-18T18:49:00.000-07:00

By Peta Bee

We reveal how to get the enviable physiques of the stars. This week: David Beckham’s thighs.

He might be in the twilight of his football career, but Beckham’s thighs are in as good a shape as ever.
His exercise regime used to include lots of weight lifting, but that caused him to gain a stone in weight and, he said, made running difficult.

Toned: Footballer David Beckham regularly goes running and does leg strengthening exercises to stay in shape

So a few years ago he switched to doing an hour of Pilates a day, and more running and exercises to strengthen his upper legs.

More...

He also refined his diet and his body fat reportedly dropped from 13.7 per cent to 8.5 per cent as a result.

TRY THIS:

Cone-jumping is a footballer’s favourite and a great way to strengthen and tone thighs.
Place five or six small cones about 50cm apart in a straight line on a non-slip floor or outside.
Stand 1ft behind the first cone with your feet hip-width apart, arms by your sides.
Fully extending your hips, knees and ankles, jump over the top of the first cone. Keep your feet level with each other in the air.
Land softly, bending forward at the waist and rolling into the heels. Push hips down to absorb the impact of landing.
With a brief pause, jump upwards and over the next cone. Continue for all six and repeat two or three times.

Health Care Review...

Benefits and Efficacy Honeycomb (Propolis) for Health

Dance Batok Padang, West Sumatera

Gout

Abstinence gout sufferers

Additional ips for gout sufferers

Women who go jogging a week before their period is due risk damaging their knees

12 Ways to Fight Stress and Help Your Heart

Can stress hurt your heart?

1. Focus on relaxation

2. Connect with friends

3. Forget perfect

4. Don’t hold grudges

5. Lighten up

6. Don’t drink (too much) alcohol

7. Cut the caffeine

8. Limit emotional involvement

9. Eat right

10. Seek help for depression

11. Get some sleep

12. Exercise more

Do Stressful Jobs Fuel Heart Attacks?

Women with high-stress jobs may be more likely to have a heart attack

12 tips for healthy hair: get the shine, movement and softness you desirefast and easywith our expert advice from top pros

by Kathy Miller Kramer

The sour truth about apple cider vinegar - evaluation of therapeutic use

Working women more likely to put on weight 'as they put office needs over their health'

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One in six cancers are caused by preventable infections

Less Inflammatory Bowel Disease Seen in Southern Latitudes

Fecal Calprotectin Helps Spot Pediatric Inflammatory Bowel Disease

Patients With IBD Fare Well on Their Travels

Fecal Calprotectin Helps Spot Pediatric IBD

Youths With IBD May Need Large Doses of Vitamin D

Stress levels and smoking: Why your dad's bad habits may have wrecked your genes

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Popular diabetes drug 'could make anti-depressants more effective'

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Teenager, 19, who thought her watery eye was caused by make-up discovers it is CANCER tumour behind her nose

WHAT IS OLFACTORY NEUROBLASTOMA?

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Pass the ice cream: Fat people can be as healthy as thin people (as long as they exercise)

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Why control pants can give you panic attacks... and the other hazards of too-tight clothes

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TIGHT TROUSERS

TIES AND COLLARS

SHOES

UNDERWEAR

BRAS

Secrets of an A-list body: How to get thighs like David Beckham's

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12 tips for healthy hair: get the shine, movement and softness you desirefast and easywith our expert advice from top pros