TRIGGER current issue

Vol. 18, No. 3

noreply@blogger.com (Pierre) — Sat, 04 Feb 2012 14:57:00 +0000

TRIGGER
The Twice-Monthly Electronic Newsletter on the Biology of Tissue Factor, Factor VII and TFPI
Vol. 18, No. 3 February 1, 2012

(The next issue will be on February 17, 2012)

__________________________________________________________
TRIGGER is also available by RSS Feed:

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and BLOG:
http://trigger-tf7.blogspot.com/
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PAPERS IN PRESS
None submitted for this issue.
__________________________________________________________
RECENT PUBLICATIONS ON TISSUE FACTOR, FACTOR VII, AND TFPI

Papers are culled from NLM MedLine (PubMed). Titles in square brackets indicate that the paper was not published in English. References that lack volume or page numbers are typically electronic pre-publications (E-pubs) ahead of the print publication; if so, the final citation with volume and page numbers may or may not appear in a future issue of Trigger.

THE FOLLOWING LINK WILL TAKE YOU TO THE ENTIRE LIST OF THIS ISSUE'S PUBLICATIONS IN A PUBMED "COLLECTION":
http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/1XoLfaNpIeJfor-4O9iaF2p/

Abbate R, Cioni G, Ricci I, Miranda M, Gori AM (2012) Thrombosis and Acute coronary syndrome. Thromb Res.
http://www.ncbi.nlm.nih.gov/pubmed/22281070

Andersen LM, Andreasen PA, Svendsen I, Keemink J, Ostergaard H, Persson E (2012) Antibody-induced enhancement of factor VIIa activity through distinct allosteric pathways. J Biol Chem.
http://www.ncbi.nlm.nih.gov/pubmed/22275370

Ando K, Ishibashi T, Ohkawara H, Inoue N, Sugimoto K, Uekita H, . . . Takeishi Y (2011) Crucial role of membrane type 1 matrix metalloproteinase (MT1- MMP) in RhoA/Rac1-dependent signaling pathways in thrombin- stimulated endothelial cells. J Atheroscler Thromb 18:762-773.
http://www.ncbi.nlm.nih.gov/pubmed/21628952

Angelillo-Scherrer A (2012) Leukocyte-derived microparticles in vascular homeostasis. Circ Res 110:356-369.
http://www.ncbi.nlm.nih.gov/pubmed/22267840

Arderiu G, Pena E, Aledo R, Juan-Babot O, Badimon L (2011) Tissue factor regulates microvessel formation and stabilization by induction of chemokine (C-C motif) ligand 2 expression. Arterioscler Thromb Vasc Biol 31:2607-2615.
http://www.ncbi.nlm.nih.gov/pubmed/21868706

Ataga KI, Brittain JE, Desai P, May R, Jones S, Delaney J, . . . Key NS (2012) Association of coagulation activation with clinical complications in sickle cell disease. PLoS One 7:e29786.
http://www.ncbi.nlm.nih.gov/pubmed/22253781

Badeanlou L, Furlan-Freguia C, Yang G, Ruf W, Samad F (2011) Tissue factor-protease-activated receptor 2 signaling promotes diet-induced obesity and adipose inflammation. Nat Med 17:1490-1497.
http://www.ncbi.nlm.nih.gov/pubmed/22019885

Barua A, Rao VP, Ramesh B, Barua B, El-Shafei H (2011) Salvage use of activated recombinant factor VII in the management of refractory bleeding following cardiac surgery. J Blood Med 2:131-134.
http://www.ncbi.nlm.nih.gov/pubmed/22287872

Bastarache JA, Sebag SC, Grove BS, Ware LB (2011) Interferon-gamma and tumor necrosis factor-alpha act synergistically to up-regulate tissue factor in alveolar epithelial cells. Exp Lung Res 37:509-517.
http://www.ncbi.nlm.nih.gov/pubmed/21913843

Bobbert P, Eisenreich A, Weithauser A, Schultheiss HP, Rauch U (2011) Leptin and resistin induce increased procoagulability in diabetes mellitus. Cytokine 56:332-337.
http://www.ncbi.nlm.nih.gov/pubmed/21733717

Bretz N, Noske A, Keller S, Erbe-Hofmann N, Schlange T, Salnikov AV, . . . Altevogt P (2012) CD24 promotes tumor cell invasion by suppressing tissue factor pathway inhibitor-2 (TFPI-2) in a c-Src-dependent fashion. Clin Exp Metastasis 29:27-38.
http://www.ncbi.nlm.nih.gov/pubmed/21984372

Brown CV, Sowery L, Curry E, Valadka AB, Glover CS, Grabarkewitz K, . . . Admire J (2012) Recombinant Factor VIIa to Correct Coagulopathy in Patients with Traumatic Brain Injury Presenting to Outlying Facilities Before Transfer to the Regional Trauma Center. Am Surg 78:57-60.
http://www.ncbi.nlm.nih.gov/pubmed/22273315

Conti F, Alessandri C, Sorice M, Capozzi A, Longo A, Garofalo T, . . . Valesini G (2012) Thin-layer chromatography immunostaining in detecting anti-phospholipid antibodies in seronegative anti-phospholipid syndrome. Clin Exp Immunol 167:429-437.
http://www.ncbi.nlm.nih.gov/pubmed/22288586

Donati MB, Lorenzet R (2012) Thrombosis and cancer: 40years of research. Thromb Res.
http://www.ncbi.nlm.nih.gov/pubmed/22264938

Ettelaie C, Fountain D, Collier ME, Elkeeb AM, Xiao YP, Maraveyas A (2011) Low molecular weight heparin downregulates tissue factor expression and activity by modulating growth factor receptor-mediated induction of nuclear factor-kappaB. Biochim Biophys Acta 1812:1591-1600.
http://www.ncbi.nlm.nih.gov/pubmed/21946214

Fadzil F (2011) Recurrent intracranial haemorrhages in a patient with factor seven deficiency: a case report. Med J Malaysia 66:261-263.
http://www.ncbi.nlm.nih.gov/pubmed/22111455

Foley JH, Butenas S, Mann KG, Brummel-Ziedins KE (2012) Measuring the mechanical properties of blood clots formed via the tissue factor pathway of coagulation. Anal Biochem.
http://www.ncbi.nlm.nih.gov/pubmed/22266209

Forte GI, Vaccarino L, Palmeri M, Branzi A, Caldarera CM, Scola L, . . . Lio D (2011) Analysis of polymorphisms Leiden Factor V G1691A and prothrombin G20210A as risk factors for acute myocardial infarction. Biogerontology 12:485-490.
http://www.ncbi.nlm.nih.gov/pubmed/21918818

Goksedef D, Panagopoulos G, Nassiri N, Levine RL, Hountis PG, Plestis KA (2012) Intraoperative use of recombinant activated factor VII during complex aortic surgery. J Thorac Cardiovasc Surg.
http://www.ncbi.nlm.nih.gov/pubmed/22285329

Gurusamy KS, Pissanou T, Pikhart H, Vaughan J, Burroughs AK, Davidson BR (2011) Methods to decrease blood loss and transfusion requirements for liver transplantation. Cochrane Database Syst Rev 12:CD009052.
http://www.ncbi.nlm.nih.gov/pubmed/22161443

Hall CL, Zaman FS (2012) A Computational Analysis of an In Vitro Vessel Wall Injury Model. Ann Biomed Eng.
http://www.ncbi.nlm.nih.gov/pubmed/22290588

Han CS, Schatz F, Lockwood CJ (2011) Abruption-associated prematurity. Clin Perinatol 38:407-421.
http://www.ncbi.nlm.nih.gov/pubmed/21890016

Hemmeryckx B, Van Hove CE, Fransen P, Emmerechts J, Kauskot A, Bult H, . . . Hoylaerts MF (2011) Progression of the prothrombotic state in aging Bmal1-deficient mice. Arterioscler Thromb Vasc Biol 31:2552-2559.
http://www.ncbi.nlm.nih.gov/pubmed/21799179

Herrera RN, Diaz de Amaya EI, Perez Aguilar RC, Joo Turoni C, Maranon R, Berman SG, . . . Peral de Bruno M (2011) Inflammatory and prothrombotic activation with conserved endothelial function in patients with chronic, asymptomatic Chagas disease. Clin Appl Thromb Hemost 17:502-507.
http://www.ncbi.nlm.nih.gov/pubmed/20699256

Hot A, Lenief V, Miossec P (2012) Combination of IL-17 and TNFalpha induces a pro-inflammatory, pro-coagulant and pro-thrombotic phenotype in human endothelial cells. Ann Rheum Dis.
http://www.ncbi.nlm.nih.gov/pubmed/22258491

Jan JY, Lin SY, Lin CH, Lee CN, Fan SZ, Han YY (2011) Recombinant activated factor VII as a promising adjuvant therapy for postpartum hemorrhage in the practice of obstetric anesthesia: experience from a university hospital in Taiwan. J Obstet Gynaecol Res 37:901-907.
http://www.ncbi.nlm.nih.gov/pubmed/21736669

Ji M, Yi S, Yu D, Wang W (2011) [siRNA-mediated tissue factor knockdown in porcine neonatal islet cell clusters in vitro]. Zhong Nan Da Xue Xue Bao Yi Xue Ban 36:1141-1146.
http://www.ncbi.nlm.nih.gov/pubmed/22246358

Kassel KM, Owens AP, 3rd, Rockwell CE, Sullivan BP, Wang R, Tawfik O, . . . Luyendyk JP (2011) Protease-activated receptor 1 and hematopoietic cell tissue factor are required for hepatic steatosis in mice fed a Western diet. Am J Pathol 179:2278-2289.
http://www.ncbi.nlm.nih.gov/pubmed/21907177

Kathuria A, Priya N, Chand K, Singh P, Gupta A, Jalal S, . . . Sharma SK (2011) Substrate specificity of acetoxy derivatives of coumarins and quinolones towards Calreticulin mediated transacetylation: Investigations on antiplatelet function. Bioorg Med Chem.
http://www.ncbi.nlm.nih.gov/pubmed/22264757

Kopp CW, Gremmel T, Steiner S, Seidinger D, Minar E, Maurer G, Huber K (2011) Platelet-monocyte cross talk and tissue factor expression in stable angina vs. unstable angina/non ST-elevation myocardial infarction. Platelets 22:530-536.
http://www.ncbi.nlm.nih.gov/pubmed/21557685

Kotani Y, Shiota M, Umemoto M, Koike E, Tsuritani M, Hoshiai H (2011) Case of acquired hemophilia with factor VIII inhibitor in a mother and newborn. J Obstet Gynaecol Res 37:1102-1105.
http://www.ncbi.nlm.nih.gov/pubmed/21450023

Le Sache F, Le Bonniec B, Gaussem P, Dizier B, Tagzirt M, Godier A, . . . Samama CM (2012) Recombinant activated factor VII and prothrombin complex concentrates have different effects on bleeding and arterial thrombosis in the haemodiluted rabbit. Br J Anaesth.
http://www.ncbi.nlm.nih.gov/pubmed/22258204

Leighton BL, Wall MH, Lockhart EM, Phillips LE, Zatta AJ (2011) Use of recombinant factor VIIa in patients with amniotic fluid embolism: a systematic review of case reports. Anesthesiology 115:1201-1208.
http://www.ncbi.nlm.nih.gov/pubmed/21720243

Liang YJ, Ma XC, Li X (2010) [The role of p38 mitogen-activated protein kinase/nuclear factor-KappaB transduction pathway on coagulation disorders due to endothelial injury induced by sepsis]. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 22:528-532.
http://www.ncbi.nlm.nih.gov/pubmed/20854731

Lipworth W, Kerridge I, Little M, Day R (2012) Evidence and desperation in off-label prescribing: recombinant factor VIIa. BMJ 344:d7926.
http://www.ncbi.nlm.nih.gov/pubmed/22250217

Liu ML, Williams KJ (2012) Microvesicles: potential markers and mediators of endothelial dysfunction. Curr Opin Endocrinol Diabetes Obes.
http://www.ncbi.nlm.nih.gov/pubmed/22248645

Mackman N, Davis GE (2011) Blood coagulation and blood vessel development: is tissue factor the missing link? Arterioscler Thromb Vasc Biol 31:2364-2366.
http://www.ncbi.nlm.nih.gov/pubmed/22011746

Marchetti M, Russo L, Balducci D, Falanga A (2011) All trans-retinoic acid modulates the procoagulant activity of human breast cancer cells. Thromb Res 128:368-374.
http://www.ncbi.nlm.nih.gov/pubmed/21458031

Martinet W, Schrijvers DM, De Meyer GR (2011) Necrotic cell death in atherosclerosis. Basic Res Cardiol 106:749-760.
http://www.ncbi.nlm.nih.gov/pubmed/21611880

Medioni J, Guastalla JP, Drouet L (2012) Thrombosis and breast cancer: incidence, risk factors, physiopathology and treatment. Bull Cancer.
http://www.ncbi.nlm.nih.gov/pubmed/22285357

Mitrophanov AY, Reifman J (2011) Kinetic modeling sheds light on the mode of action of recombinant factor VIIa on thrombin generation. Thromb Res 128:381-390.
http://www.ncbi.nlm.nih.gov/pubmed/21641634

Mulder R, Ten Kate MK, Kluin-Nelemans HC, Mulder AB (2012) PROS1 Heerlen polymorphism is associated with increased free plasma tissue factor pathway inhibitor levels. Thromb Haemost 107.
http://www.ncbi.nlm.nih.gov/pubmed/22273984

Nadir Y, Kenig Y, Drugan A, Shafat I, Brenner B (2011) An assay to evaluate heparanase procoagulant activity. Thromb Res 128:e3-8.
http://www.ncbi.nlm.nih.gov/pubmed/21481923

Naumnik B, Rydzewska-Rosolowska A, Mysliwiec M (2011) Different effects of enoxaparin, nadroparin, and dalteparin on plasma TFPI during hemodialysis: a prospective crossover randomized study. Clin Appl Thromb Hemost 17:480-486.
http://www.ncbi.nlm.nih.gov/pubmed/20682597

Ogawa Y, Nishida Y, Kyo T, Miki H, Yonemoto H, Bandou H, . . . Shirasaka T (2011) [Successful completion of left total hip arthroplasty by inhibitor neutralization therapy in a hemophilia B patient with high responding inhibitor]. Rinsho Ketsueki 52:713-717.
http://www.ncbi.nlm.nih.gov/pubmed/21897080

Oishi K, Koyanagi S, Ohkura N (2011) Circadian mRNA expression of coagulation and fibrinolytic factors is organ-dependently disrupted in aged mice. Exp Gerontol 46:994-999.
http://www.ncbi.nlm.nih.gov/pubmed/21963655

Pacheco LD, Saade GR, Gei AF, Hankins GD (2011) Cutting-edge advances in the medical management of obstetrical hemorrhage. Am J Obstet Gynecol 205:526-532.
http://www.ncbi.nlm.nih.gov/pubmed/21816382

Parunov LA, Fadeeva OA, Balandina AN, Soshitova NP, Kopylov KG, Kumskova MA, . . . Panteleev MA (2011) Improvement of spatial fibrin formation by the anti-TFPI aptamer BAX499: changing clot size by targeting extrinsic pathway initiation. J Thromb Haemost 9:1825-1834.
http://www.ncbi.nlm.nih.gov/pubmed/21696535

Reimer J, Bien S, Ameling S, Hammer E, Volker U, Hempel G, . . . Ritter CA (2012) Antineoplastic agent busulfan regulates a network of genes related to coagulation and fibrinolysis. Eur J Clin Pharmacol.
http://www.ncbi.nlm.nih.gov/pubmed/22286157

Reitter-Pfoertner S, Horvath B, Lechner K, Sunder-Plassmann R, Mannhalter C, Pabinger I (2012) Inhibitor development in two patients with mild haemophilia A - spontaneous disappearance and no recurrence of the inhibitor after re-challenge. Wien Klin Wochenschr.
http://www.ncbi.nlm.nih.gov/pubmed/22249861

Roumenina LT, Frimat M, Miller EC, Provot F, Dragon-Durey MA, Bordereau P, . . . Fremeaux-Bacchi V (2012) A prevalent C3 mutation in aHUS patients causes a direct C3 convertase gain-of-function. Blood.
http://www.ncbi.nlm.nih.gov/pubmed/22246034

Sheth S, Soff G, Mitchell B, Green D, Kaicker S, Fireman F, . . . Aledort L (2012) Managing incidentally diagnosed isolated factor VII deficiency perioperatively: a brief expert consensus report. Expert Rev Hematol 5:47-50.
http://www.ncbi.nlm.nih.gov/pubmed/22272705

Stephan F, Aarden LA, Zeerleder S (2012) FSAP, a new player in inflammation? Hamostaseologie 32:51-55.
http://www.ncbi.nlm.nih.gov/pubmed/22252569

Taniguchi M, Ono N, Hayashi A, Yakura Y, Takeya H (2011) Effect of dibutyryl cyclic adenosine monophosphate on the gene expression of plasminogen activator inhibitor-1 and tissue factor in adipocytes. Thromb Res 128:375-380.
http://www.ncbi.nlm.nih.gov/pubmed/21496886

Tetik S, Ak K, Sahin Y, Gulsoy O, Isbir S, Arsan S, Yardimci T (2011) Postoperative statin therapy attenuates the intensity of systemic inflammation and increases fibrinolysis after coronary artery bypass grafting. Clin Appl Thromb Hemost 17:526-531.
http://www.ncbi.nlm.nih.gov/pubmed/20805103

Undas A, Jankowski M, Kaczmarek P, Sladek K, Brummel-Ziedins K (2011) Thrombin generation in chronic obstructive pulmonary disease: dependence on plasma factor composition. Thromb Res 128:e24-28.
http://www.ncbi.nlm.nih.gov/pubmed/21624643

van der Poll T, Levi M (2012) Crosstalk between Inflammation and Coagulation: The Lessons of Sepsis. Curr Vasc Pharmacol.
http://www.ncbi.nlm.nih.gov/pubmed/22272914

Walsh M, Thomas SG, Howard JC, Evans E, Guyer K, Medvecz A, . . . Castellino FJ (2011) Blood component therapy in trauma guided with the utilization of the perfusionist and thromboelastography. J Extra Corpor Technol 43:162-167.
http://www.ncbi.nlm.nih.gov/pubmed/22164456

Wang R, Zhang SF, Ma YT, Chen D, Ma J, Zhou YM, Wen BZ (2011) [Expression of tissue factor in monocytes and plasma during acute phase and recovery stage of patients with myocardial infarction]. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 23:372-373.
http://www.ncbi.nlm.nih.gov/pubmed/21672391

Wu Z, Liu MC, Liang M, Fu J (2012) Sirt1 protects against thrombomodulin downregulation and lung coagulation following particulate matter exposure. Blood.
http://www.ncbi.nlm.nih.gov/pubmed/22262770

Zhang N, Lawrence DA (2011) Tissue factor and obesity, a two-way street. Nat Med 17:1343-1344.
http://www.ncbi.nlm.nih.gov/pubmed/22064407

Zheng XW, Kudaravalli R, Russell TT, DiMichele DM, Gibb C, Russell JE, . . . Pollak ES (2011) Mutation in the factor VII hepatocyte nuclear factor 4alpha-binding site contributes to factor VII deficiency. Blood Coagul Fibrinolysis 22:624-627.
http://www.ncbi.nlm.nih.gov/pubmed/21760481

Zhou ZY, Hay JW (2012) Efficacy of Bypassing Agents in Patients With Hemophilia and Inhibitors: A Systematic Review and Meta-Analysis. Clin Ther.
http://www.ncbi.nlm.nih.gov/pubmed/22285208
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ABOUT TRIGGER
TRIGGER is edited by Jim Morrissey and Pierre Neuenschwander, with editorial assistance by Genie Morrissey. It includes Abstracts of Papers in Press, Meeting Announcements, Positions Sought/Available,or any other pertinent item that subscribers may want to share with their colleagues. To submit an item for publication in Trigger, e-mail us. To request or cancel a subscription,or for more information about TRIGGER or the biology of tissue factor and factor VII, visit our web site. You can also contact us by mail: J.H. Morrissey, University of Illinois College of Medicine, 417 Med Sci Bldg MC-714, 506 S. Mathews Ave., Urbana, IL 61801, USA.

DISCLAIMER: TRIGGER is provided "as is" for information purposes only and without warranty of any kind, express or implied. Users shall assume the entire risk as to the accuracy and usefulness of information in TRIGGER. Opinions expressed here are not necessarily those of the editors or their employers. You may share TRIGGER with your scientific colleagues but you are not permitted to use it or its contents for commercial purposes.
__________________________________________________________

Vol. 18, No. 2

noreply@blogger.com (Pierre) — Wed, 18 Jan 2012 03:22:00 +0000

TRIGGER
The Twice-Monthly Electronic Newsletter on the Biology of Tissue Factor, Factor VII and TFPI
Vol. 18, No. 2 January 17, 2012

(The next issue will be on February 1, 2012)

__________________________________________________________
TRIGGER is also available by RSS Feed:

http://feeds.feedburner.com/blogspot/glro

THE FOLLOWING LINK WILL TAKE YOU TO THE ENTIRE LIST OF THIS ISSUE'S PUBLICATIONS IN A PUBMED "COLLECTION":
http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/12g4pzVJvrgr5Uqj5JD6Vcp/

Benagiano M, Munari F, Ciervo A, Amedei A, Paccani SR, Mancini F, . . . D'Elios MM (2012) Chlamydophila pneumoniae phospholipase D (CpPLD) drives Th17 inflammation in human atherosclerosis. Proc Natl Acad Sci U S A.
http://www.ncbi.nlm.nih.gov/pubmed/22232679

Ben-Hadj-Khalifa S, Hezard N, Almawi WY, Lakbakbi S, Mace C, Cornillet-Lefebvre P, . . . Nguyen P (2011) IL-10 modulates fondaparinux inhibition of monocyte-induced thrombin generation. J Thromb Thrombolysis 32:311-317.
http://www.ncbi.nlm.nih.gov/pubmed/21725623

Bind MA, Baccarelli A, Zanobetti A, Tarantini L, Suh H, Vokonas P, Schwartz J (2012) Air Pollution and Markers of Coagulation, Inflammation, and Endothelial Function: Associations and Epigene-environment Interactions in an Elderly Cohort. Epidemiology.
http://www.ncbi.nlm.nih.gov/pubmed/22237295

Chan CM, Shorr AF, Perkins JG (2012) Factors associated with acute lung injury in combat casualties receiving massive blood transfusions: A retrospective analysis. J Crit Care.
http://www.ncbi.nlm.nih.gov/pubmed/22227085

Chen XD, Li ZW, Zhang J, Mao ZH, Ma D, Wang HJ (2012) Tissue factor pathway inhibitor-2 may interact with nuclear protein RASSF1C. Acta Biochim Biophys Sin (Shanghai).
http://www.ncbi.nlm.nih.gov/pubmed/22232300

Dahm AE, Eilertsen AL, Goeman J, Olstad OK, Ovstebo R, Kierulf P, . . . Sandset PM (2012) A microarray study on the effect of four hormone therapy regimens on gene transcription in whole blood from healthy postmenopausal women. Thromb Res.
http://www.ncbi.nlm.nih.gov/pubmed/22217510

Fang Y, Cai JY, Zhong JH, Zhong H, Wang HR, Chen FY (2011) [Expression of alternatively spliced human tissue factor in acute leukemia cells]. Zhongguo Shi Yan Xue Ye Xue Za Zhi 19:288-292.
http://www.ncbi.nlm.nih.gov/pubmed/21518473

Fogelson AL, Hussain YH, Leiderman K (2012) Blood Clot Formation under Flow: The Importance of Factor XI Depends Strongly on Platelet Count. Biophys J 102:10-18.
http://www.ncbi.nlm.nih.gov/pubmed/22225793

Girolami A, Bertozzi I, de Marinis GB, Bonamigo E, Fabris F (2011) Activated FVII levels in factor VII Padua (Arg304Gln) coagulation disorder and in true factor VII deficiency: a study in homozygotes and heterozygotes. Hematology 16:308-312.
http://www.ncbi.nlm.nih.gov/pubmed/21902896

Girolami A, Bertozzi I, Rigoni I, Muzzolon R, Vettore S (2011) Congenital FVII deficiency and thrombotic events after replacement therapy. J Thromb Thrombolysis 32:362-367.
http://www.ncbi.nlm.nih.gov/pubmed/21681394

Gudmundsdottir BR, Francis CW, Bjornsdottir AM, Nellbring M, Onundarson PT (2012) Critical role of factors II and X during coumarin anticoagulation and their combined measurement with a new Fiix-prothrombin time. Thromb Res.
http://www.ncbi.nlm.nih.gov/pubmed/22225856

Hahn N, Heiden M, Seitz R, Salge-Bartels U (2012) Inducible expression of tissue factor in small-cell lung cancer: impact on morphology and matrix metalloproteinase secretion. J Cancer Res Clin Oncol.
http://www.ncbi.nlm.nih.gov/pubmed/22237453

Hammad MA, Abdel-Bakky MS, Walker LA, Ashfaq MK (2011) Oxidized low-density lipoprotein and tissue factor are involved in monocrotaline/lipopolysaccharide-induced hepatotoxicity. Arch Toxicol 85:1079-1089.
http://www.ncbi.nlm.nih.gov/pubmed/21279329

Ho KM, Litton E (2011) Cost-effectiveness of using recombinant activated factor VII as an off-label rescue treatment for critical bleeding requiring massive transfusion. Transfusion.
http://www.ncbi.nlm.nih.gov/pubmed/22211634

Holroyd EW, Delacroix S, Larsen K, Harbuzariu A, Psaltis PJ, Wang L, . . . Simari RD (2012) Tissue Factor Pathway Inhibitor Blocks Angiogenesis via Its Carboxyl Terminus. Arterioscler Thromb Vasc Biol.
http://www.ncbi.nlm.nih.gov/pubmed/22223730

Holtom E, Usherwood JR, Macey MG, Lawson C (2011) Microparticle formation after co-culture of human whole blood and umbilical artery in a novel in vitro model of flow. Cytometry A.
http://www.ncbi.nlm.nih.gov/pubmed/22213485

Humphreys I, Saraiya S, Belenky W, Dworkin J (2011) Nasal packing with strips of cured pork as treatment for uncontrollable epistaxis in a patient with Glanzmann thrombasthenia. Ann Otol Rhinol Laryngol 120:732-736.
http://www.ncbi.nlm.nih.gov/pubmed/22224315

Jansen JO, Scarpelini S, Pinto R, Tien HC, Callum J, Rizoli SB (2011) Hypoperfusion in severely injured trauma patients is associated with reduced coagulation factor activity. J Trauma 71:S435-440.
http://www.ncbi.nlm.nih.gov/pubmed/22072000

Karpf DM, Sorensen BB, Hermit MB, Holmberg HL, Tranholm M, Bysted BV, . . . Stennicke HR (2011) Prolonged half-life of glycoPEGylated rFVIIa variants compared to native rFVIIa. Thromb Res 128:191-195.
http://www.ncbi.nlm.nih.gov/pubmed/21429564

Keyl C, Uhl R, Beyersdorf F, Stampf S, Lehane C, Wiesenack C, Trenk D (2011) High-dose tranexamic acid is related to increased risk of generalized seizures after aortic valve replacement. Eur J Cardiothorac Surg 39:e114-121.
http://www.ncbi.nlm.nih.gov/pubmed/21295991

Krigsfeld GS, Sanzari JK, Kennedy AR (2012) The Effects of Proton Radiation on the Prothrombin and Partial Thromboplastin Times of Irradiated Ferrets. Int J Radiat Biol.
http://www.ncbi.nlm.nih.gov/pubmed/22221163

Kristensen M, Bugel S (2011) A diet rich in oat bran improves blood lipids and hemostatic factors, and reduces apparent energy digestibility in young healthy volunteers. Eur J Clin Nutr 65:1053-1058.
http://www.ncbi.nlm.nih.gov/pubmed/21654701

Lecut C, Faccinetto C, Delierneux C, van Oerle R, Spronk HM, Evans RJ, . . . Oury C (2011) ATP-gated P2X(1) ion channels protect from endotoxemia by dampening neutrophil activation. J Thromb Haemost.
http://www.ncbi.nlm.nih.gov/pubmed/22212928

Lee AI, Campigotto F, Rawn JD, Neuberg D, Kaufman RM, Berliner N (2012) Clinical significance of coagulation studies in predicting response to activated recombinant Factor VII in cardiac surgery patients. Br J Haematol.
http://www.ncbi.nlm.nih.gov/pubmed/22224596

Lemmer R, Albrech M, Bauer G (2012) Use of FloSeal hemostatic matrix in a patient with severe postpartum hemorrhage. J Obstet Gynaecol Res.
http://www.ncbi.nlm.nih.gov/pubmed/22229547

Lindstrom OK, Tukiainen EM, Kylanpaa ML, Mentula PJ, Puolakkainen PA, Wartiovaara-Kautto UM, . . . Petaja JM (2011) Thrombin Generation in vitro and in vivo, and Disturbed Tissue Factor Regulation in Patients with Acute Pancreatitis. Pancreatology 11:557-566.
http://www.ncbi.nlm.nih.gov/pubmed/22213026

Maroney SA, Ellery PE, Wood JP, Ferrel JP, Bonesho CE, Mast AE (2012) Caveolae Optimize Tissue Factor-Factor VIIa Inhibitory Activity of Cell Surface Associated Tissue Factor Pathway Inhibitor. Biochem J.
http://www.ncbi.nlm.nih.gov/pubmed/22239091

Meade TW, Stirling Y (2012) The Northwick Park Heart Studies: contrasts Between the Two Factor VII Assays Used. J Thromb Haemost.
http://www.ncbi.nlm.nih.gov/pubmed/22235852

Mobarrez F, He S, Broijersen A, Wiklund B, Antovic A, Antovic J, . . . Wallen H (2011) Atorvastatin reduces thrombin generation and expression of tissue factor, P-selectin and GPIIIa on platelet-derived microparticles in patients with peripheral arterial occlusive disease. Thromb Haemost 106:344-352.
http://www.ncbi.nlm.nih.gov/pubmed/21614411

Moertl D, Berger R, Hammer A, Hutuleac R, Koppensteiner R, Kopp CW, Steiner S (2011) Dose-dependent decrease of platelet activation and tissue factor by omega-3 polyunsaturated fatty acids in patients with advanced chronic heart failure. Thromb Haemost 106:457-465.
http://www.ncbi.nlm.nih.gov/pubmed/21800004

Newell-Caito JL, Laha M, Tharp AC, Creamer JI, Xu H, Maddur AA, . . . Bock PE (2011) Notecarin D binds human factor V and factor Va with high affinity in the absence of membranes. J Biol Chem 286:38286-38297.
http://www.ncbi.nlm.nih.gov/pubmed/21911491

Ott I (2011) Inhibitors of the initiation of coagulation. Br J Clin Pharmacol 72:547-552.
http://www.ncbi.nlm.nih.gov/pubmed/21392058

Owens AP, 3rd, Passam FH, Antoniak S, Marshall SM, McDaniel AL, Rudel L, . . . Mackman N (2012) Monocyte tissue factor-dependent activation of coagulation in hypercholesterolemic mice and monkeys is inhibited by simvastatin. J Clin Invest.
http://www.ncbi.nlm.nih.gov/pubmed/22214850

Pepke W, Eisenreich A, Jaster M, Ayral Y, Bobbert P, Mayer A, . . . Rauch U (2011) Bivalirudin Inhibits Periprocedural Platelet Function and Tissue Factor Expression of Human Smooth Muscle Cells. Cardiovasc Ther.
http://www.ncbi.nlm.nih.gov/pubmed/22212466

Poon A, Litonjua AA, Laprise C (2011) Relevance and implication of genetic determinants to asthma pathophysiology. Curr Opin Allergy Clin Immunol 11:407-413.
http://www.ncbi.nlm.nih.gov/pubmed/21822132

Riddell A, Abdul-Kadir R, Pollard D, Tuddenham E, Gomez K (2011) Monitoring low dose recombinant factor VIIa therapy in patients with severe factor XI deficiency undergoing surgery. Thromb Haemost 106:521-527.
http://www.ncbi.nlm.nih.gov/pubmed/21833443

Schulte S (2011) Pioneering designs for recombinant coagulation factors. Thromb Res 128 Suppl 1:S9-S12.
http://www.ncbi.nlm.nih.gov/pubmed/22221848

Sie P, Samama CM, Godier A, Rosencher N, Steib A, Llau JV, . . . Albaladejo P (2011) [Surgery and invasive procedures in patients on long-term treatment with oral direct thrombin or factor Xa inhibitors]. Ann Fr Anesth Reanim 30:645-650.
http://www.ncbi.nlm.nih.gov/pubmed/21820844

Silverstein RL (2012) Teaching an old dog new tricks: potential antiatherothrombotic use for statins. J Clin Invest:1-4.
http://www.ncbi.nlm.nih.gov/pubmed/22214843

Stavenuiter F, Dienava-Verdoold I, Boon-Spijker MG, Brinkman HJ, Meijer AB, Mertens K (2012) Factor Seven Activating Protease (FSAP): does it Activate Factor VII? J Thromb Haemost.
http://www.ncbi.nlm.nih.gov/pubmed/22235940

Tarzia V, Bottio T, Buratto E, Spiezia L, Simioni P, Gerosa G (2011) The hazard of comparing apples and oranges: the proper indication for the use of recombinant activated clotting factor VII in cardiac surgery. J Thorac Cardiovasc Surg 142:1588-1589; author reply 1589.
http://www.ncbi.nlm.nih.gov/pubmed/22093717

Taylor KC, Lange LA, Zabaneh D, Lange E, Keating BJ, Tang W, . . . Reiner AP (2011) A gene-centric association scan for Coagulation Factor VII levels in European and African Americans: the Candidate Gene Association Resource (CARe) Consortium. Hum Mol Genet 20:3525-3534.
http://www.ncbi.nlm.nih.gov/pubmed/21676895

Tersteeg C, Roest M, Mak-Nienhuis EM, Ligtenberg E, Hoefer IE, de Groot PG, Pasterkamp G (2012) A fibronectin-fibrinogen-tropoelastin coating reduces smooth muscle cell growth but improves endothelial cell function. J Cell Mol Med.
http://www.ncbi.nlm.nih.gov/pubmed/22225866

Tong J, Che T, Li Y, Wang P, Xu X, Chen Y (2011) A descriptor of amino acids: SVRG and its application to peptide quantitative structure-activity relationship. SAR QSAR Environ Res 22:611-620.
http://www.ncbi.nlm.nih.gov/pubmed/21830880

Tsimerman G, Roguin A, Bachar A, Melamed E, Brenner B, Aharon A (2011) Involvement of microparticles in diabetic vascular complications. Thromb Haemost 106:310-321.
http://www.ncbi.nlm.nih.gov/pubmed/21713319

Viswabandya A, Baidya S, Nair SC, Abraham A, George B, Mathews V, . . . Srivastava A (2012) Correlating clinical manifestations with factor levels in rare bleeding disorders: a report from Southern India. Haemophilia.
http://www.ncbi.nlm.nih.gov/pubmed/22221743

Whitehead KA, Sahay G, Li GZ, Love KT, Alabi CA, Ma M, . . . Anderson DG (2011) Synergistic silencing: combinations of lipid-like materials for efficacious siRNA delivery. Mol Ther 19:1688-1694.
http://www.ncbi.nlm.nih.gov/pubmed/21750531

Zareh M, Davis A, Henderson S (2011) Reversal of warfarin-induced hemorrhage in the emergency department. West J Emerg Med 12:386-392.
http://www.ncbi.nlm.nih.gov/pubmed/22224125
Zhao B, Luo X, Shi H, Ma D (2011) Tissue factor pathway inhibitor-2 is downregulated by ox-LDL and inhibits ox-LDL induced vascular smooth muscle cells proliferation and migration. Thromb Res 128:179-185.
http://www.ncbi.nlm.nih.gov/pubmed/21458846
__________________________________________________________

Vol. 18, No. 1

noreply@blogger.com (Pierre) — Tue, 03 Jan 2012 19:29:00 +0000

TRIGGER
The Twice-Monthly Electronic Newsletter on the Biology of Tissue Factor, Factor VII and TFPI
Vol. 18, No. 1 January 3, 2012

(The next issue will be on January 17, 2012)

__________________________________________________________
TRIGGER is also available by RSS Feed:

http://feeds.feedburner.com/blogspot/glro

and BLOG:
http://trigger-tf7.blogspot.com/
__________________________________________________________
ANNOUNCEMENTS
As we have done for the past two years, the individual PubMed "collections" of the papers appearing in each issue of TRIGGER for 2011 have now been consolidated into a single collection. (The individual PubMed collections for each TRIGGER issue in 2011 have, accordingly, been deleted.) Here are the links to the consolidated collections for the past three years:

2009 (301 references):
http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/1z_kd2hNzEEY8Wpxz8t1rph/

2010 (531references):
http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/1-cH907gHdg5lzzYz_yPkW5/

2011 (612 references):
http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/1bOQXIskFcJPXOjjcawlCfD/
__________________________________________________________
PAPERS IN PRESS
None submitted for this issue.
__________________________________________________________
RECENT PUBLICATIONS ON TISSUE FACTOR, FACTOR VII, AND TFPI

THE FOLLOWING LINK WILL TAKE YOU TO THE ENTIRE LIST OF THIS ISSUE'S PUBLICATIONS IN A PUBMED "COLLECTION":
http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/1dUWxDhhurzbOreoEFLTYft/

Basavaraj MG, Sovershaev MA, Egorina EM, Gruber FX, Bogdanov VY, Fallon JT, . . . Hansen JB (2011) Circulating monocytes mirror the imbalance in TF and TFPI expression in carotid atherosclerotic plaques with lipid-rich and calcified morphology. Thromb Res.
http://www.ncbi.nlm.nih.gov/pubmed/22178066

Bauer EM, Zheng H, Comhair S, Erzurum S, Billiar TR, Bauer PM (2011) Complement c3 deficiency attenuates chronic hypoxia-induced pulmonary hypertension in mice. PLoS One 6:e28578.
http://www.ncbi.nlm.nih.gov/pubmed/22194859

Bhat S, Yadav SP, Anjan M, Dinand V, Sachdeva A (2011) Recombinant activated factor VII usage in life threatening hemorrhage: a pediatric experience. Indian J Pediatr 78:961-968.
http://www.ncbi.nlm.nih.gov/pubmed/21328080

Branchini A, Rizzotto L, Mariani G, Napolitano M, Lapecorella M, Giansily-Blaizot M, . . . Bernardi F (2011) Natural and engineered carboxy-terminal variants: decreased secretion and gain-of-function result in asymptomatic coagulation factor VII deficiency. Haematologica.
http://www.ncbi.nlm.nih.gov/pubmed/22180436

Broze GJ, Jr., Girard TJ (2012) Tissue factor pathway inhibitor: structure-function. Front Biosci 17:262-280.
http://www.ncbi.nlm.nih.gov/pubmed/22201743

Butenas S, Amblo-Krudysz J, Mann KG (2012) Posttranslational modifications of tissue factor. Front Biosci (Elite Ed) 4:381-391.
http://www.ncbi.nlm.nih.gov/pubmed/22201880

Camera M, Brambilla M, Facchinetti L, Canzano P, Spirito R, Rossetti L, . . . Tremoli E (2011) Tissue Factor and Atherosclerosis: Not only vessel wall-derived TF, but also platelet-associated TF. Thromb Res.
http://www.ncbi.nlm.nih.gov/pubmed/22178579

Darlington DN, Delgado AV, Kheirabadi BS, Fedyk CG, Scherer MR, Pusateri AE, . . . Dubick MA (2011) Effect of hemodilution on coagulation and recombinant factor VIIa efficacy in human blood in vitro. J Trauma 71:1152-1163.
http://www.ncbi.nlm.nih.gov/pubmed/21610535

Delacroix S, Simari RD (2012) Tissue Factor-Thrombin-PAR-1 Pathway: A Novel Link Between Bone Marrow and Blood Vessel. Arterioscler Thromb Vasc Biol 32:3-4.
http://www.ncbi.nlm.nih.gov/pubmed/22173975

Dong X, Song L, Zhu D, Zhang H, Liu L, Leng X (2011) Tissue factor pathway inhibitor suppresses the growth of human vascular smooth muscle cells through regulating cell cycle. Mol Biol Rep 38:4771-4776.
http://www.ncbi.nlm.nih.gov/pubmed/21132373

Elmer J, Wittels KA (2011) Emergency reversal of pentasaccharide anticoagulants: a systematic review of the literature. Transfus Med.
http://www.ncbi.nlm.nih.gov/pubmed/22171588

Fukuda T, Honda Y, Kamisato C, Morishima Y, Shibano T (2011) Reversal of anticoagulant effects of edoxaban, an oral, direct factor Xa inhibitor, with haemostatic agents. Thromb Haemost 107.
http://www.ncbi.nlm.nih.gov/pubmed/22186946

Govindarajan S, Sivakumar J, Garimidi P, Rangaraj N, Kumar JM, Rao NM, Gopal V (2011) Targeting human epidermal growth factor receptor 2 by a cell-penetrating peptide-affibody bioconjugate. Biomaterials.
http://www.ncbi.nlm.nih.gov/pubmed/22192536

Hampton AL, Diaz JA, Hawley AE, Wrobleski SK, Wang JG, Lee RD, . . . Myers DD, Jr. (2011) Myeloid cell tissue factor does not contribute to venous thrombogenesis in an electrolytic injury model. Thromb Res.
http://www.ncbi.nlm.nih.gov/pubmed/22192154

Harkouk H, Chakib Rahmoune F, Benhamou D (2011) [Postpartum haemorrhage and factor VII deficiency.]. Ann Fr Anesth Reanim.
http://www.ncbi.nlm.nih.gov/pubmed/22197042

Haynes LM, Dubief YC, Mann KG (2011) Membrane binding events in the initiation and propagation phases of tissue factor initiated zymogen activation under flow. J Biol Chem.
http://www.ncbi.nlm.nih.gov/pubmed/22187432

Hedner U (2012) FVIIa as therapeutic agent in hemophilia and beyond. Front Biosci (Elite Ed) 4:1210-1223.
http://www.ncbi.nlm.nih.gov/pubmed/22201947

Hoffman M, Monroe DM (2012) The multiple roles of tissue factor in wound healing. Front Biosci (Schol Ed) 4:713 -721.
http://www.ncbi.nlm.nih.gov/pubmed/22202116

Holroyd EW, White TA, Pan S, Simari RD (2012) Tissue factor pathway inhibitor as a multifunctional mediator of vascular structure. Front Biosci (Elite Ed) 4:392-400.
http://www.ncbi.nlm.nih.gov/pubmed/22201881

Jansen JO, Scarpelini S, Pinto R, Tien HC, Callum J, Rizoli SB (2011) Hypoperfusion in severely injured trauma patients is associated with reduced coagulation factor activity. J Trauma 71:S435-440.
http://www.ncbi.nlm.nih.gov/pubmed/22072000

Kuperman AA, Kenet G, Papadakis E, Brenner B (2011) Intraventricular hemorrhage in preterm infants: coagulation perspectives. Semin Thromb Hemost 37:730-736.
http://www.ncbi.nlm.nih.gov/pubmed/22187395

Lester PA, Diaz JA, Shuster KA, Henke PK, Wakefield TW, Myers DD (2012) Inflammation and thrombosis: new insights. Front Biosci (ScholEd) 4:620-638.
http://www.ncbi.nlm.nih.gov/pubmed/22202081

Li S, Zhang S, Li N, Li Z, Yu B, Tian Y (2011) Arterial Smooth Muscle Injury causes Blood Tissue Factor Elevation Predicting Restenosis after PCI. Scand Cardiovasc J.
http://www.ncbi.nlm.nih.gov/pubmed/22204555

Liak C, Fitzpatrick M (2011) Coagulability in obstructive sleep apnea. Can Respir J 18:338-348.
http://www.ncbi.nlm.nih.gov/pubmed/22187690

Lippi G, Franchini M, Targher G (2011) Arterial thrombus formation in cardiovascular disease. Nat Rev Cardiol 8:502-512.
http://www.ncbi.nlm.nih.gov/pubmed/21727917

Lupu C, Zhu H, Popescu NI, Wren JD, Lupu F (2011) Novel protein ADTRP regulates TFPI expression and function in human endothelial cells in normal conditions and in response to androgen. Blood 118:4463-4471.
http://www.ncbi.nlm.nih.gov/pubmed/21868574

Mahmoodi M, Peyvandi F, Afrasiabi A, Ghaffarpasand F, Karimi M (2011) Bleeding symptoms in heterozygous carriers of inherited coagulation disorders in southern Iran. Blood Coagul Fibrinolysis 22:396-401.
http://www.ncbi.nlm.nih.gov/pubmed/21451397

Margaritis P (2012) Gene-based continuous expression of FVIIa for the treatment of hemophilia. Front Biosci (Schol Ed) 4:287-299.
http://www.ncbi.nlm.nih.gov/pubmed/22202061

Mirzaahmadi S, Asaadi-Tehrani G, Bandehpour M, Davoudi N, Tahmasbi L, Hosseinzadeh N, . . . Kazemi B (2011) Expression of recombinant human coagulation factor VII by the Lizard Leishmania expression system. J Biomed Biotechnol 2011:873874.
http://www.ncbi.nlm.nih.gov/pubmed/21912483

Motoki Y, Nojima J, Yanagihara M, Tsuneoka H, Matsui T, Yamamoto M, Ichihara K (2011) Anti-phospholipid antibodies contribute to arteriosclerosis in patients with systemic lupus erythematosus through induction of tissue factor expression and cytokine production from peripheral blood mononuclear cells. Thromb Res.
http://www.ncbi.nlm.nih.gov/pubmed/22196362

Muzaffar J, Katragadda L, Haider S, Javed A, Anaissie E, Usmani S (2011) Rituximab and intravenous immunoglobulin (IVIG) for the management of acquired factor VIII inhibitor in multiple myeloma: case report and review of literature. Int J Hematol.
http://www.ncbi.nlm.nih.gov/pubmed/22170228

Nagle EL, Tsu LV, Dager WE (2011) Bivalirudin for anticoagulation during hypothermic cardiopulmonary bypass and recombinant factor VIIa for iatrogenic coagulopathy. Ann Pharmacother 45:e47.
http://www.ncbi.nlm.nih.gov/pubmed/21862711

Napoleone E, Cutrone A, Cugino D, Amore C, Di Santo A, Iacoviello L, . . . Lorenzet R (2011) Inhibition of the renin-angiotensin system downregulates tissue factor and vascular endothelial growth factor in human breast carcinoma cells. Thromb Res.
http://www.ncbi.nlm.nih.gov/pubmed/22188725

Notarnicola A, Pesce V, Scaraggi A, Maccagnano G, Vicenti G, Moretti B (2011) Total hip replacement in a patient with acquired haemophilia A: a case report and literature review. Blood Coagul Fibrinolysis 22:436-439.
http://www.ncbi.nlm.nih.gov/pubmed/21508830

Oslakovic C, Cedervall T, Linse S, Dahlback B (2011) Polystyrene nanoparticles affecting blood coagulation. Nanomedicine.
http://www.ncbi.nlm.nih.gov/pubmed/22197724

Osterud B (2011) Tissue factor/TFPI and blood cells. Thromb Res.
http://www.ncbi.nlm.nih.gov/pubmed/22197177

Osterud B, Bjorklid E (2012) Tissue factor in blood cells and endothelial cells. Front Biosci (Elite Ed) 4:289-299.
http://www.ncbi.nlm.nih.gov/pubmed/22201871

Potaczek DP, Pieculewicz M, Mazur M, Branicka A, Nishiyama C, Okumura K, Undas A (2011) Very rare minor homozygous GG genotype of tissue factor +5466A>G mutation in a patient with two cryptogenic cerebrovascular ischemic events. Int J Cardiol 147:e13-15.
http://www.ncbi.nlm.nih.gov/pubmed/19203804

Rao LV, Kothari H, Pendurthi UR (2012) Tissue factor: mechanisms of decryption. Front Biosci (Elite Ed) 4:1513-1527.
http://www.ncbi.nlm.nih.gov/pubmed/22201972

Rolfe S, Papadopoulos S, Cabral KP (2010) Controversies of anticoagulation reversal in life-threatening bleeds. J Pharm Pract 23:217-225.
http://www.ncbi.nlm.nih.gov/pubmed/21507817

Sarode R, Matevosyan K, Bhagat R, Rutherford C, Madden C, Beshay JE (2011) Rapid warfarin reversal: a 3-factor prothrombin complex concentrate and recombinant factor VIIa cocktail for intracerebral hemorrhage. J Neurosurg.
http://www.ncbi.nlm.nih.gov/pubmed/22175718

Shapiro A, Cooper DL (2011) U.S. survey of surgical capabilities and experience with surgical procedures in patients with congenital haemophilia with inhibitors. Haemophilia.
http://www.ncbi.nlm.nih.gov/pubmed/22168829

Solheim S, Seljeflot I, Lunde K, Bratseth V, Aakhus S, Forfang K, Arnesen H (2011) The influence of intracoronary injection of bone marrow cells on prothrombotic markers in patients with acute myocardial infarction. Thromb Res.
http://www.ncbi.nlm.nih.gov/pubmed/22192151

Undas A, Machnik A, Potaczek DP, Wypasek E, Zmudka K, Tracz W (2011) Ezetimibe combined with simvastatin compared with simvastatin alone results in a greater suppression of oxidative stress and enhanced fibrinolysis in patients after acute coronary events. J Cardiovasc Pharmacol 58:167-172.
http://www.ncbi.nlm.nih.gov/pubmed/21558878

Uszynski M, Zekanowska E, Uszynski W, Kuczynski J, Zylinski A (2011) Microparticles (MPs), tissue factor (TF) and tissue factor inhibitor (TFPI) in cord blood plasma. A preliminary study and literature survey of procoagulant properties of MPs. Eur J Obstet Gynecol Reprod Biol 158:37-41.
http://www.ncbi.nlm.nih.gov/pubmed/21664032

Wang CH, Chen YC, Tsao CW, Yang SS (2011) Dalteparin-associated catastrophic retroperitoneal hematoma successfully treated with recombinant factor VIIa. Int Urol Nephrol.
http://www.ncbi.nlm.nih.gov/pubmed/22180040

Williams JC, Mackman N (2012) Tissue factor in health and disease. Front Biosci (Elite Ed) 4:358-372.
http://www.ncbi.nlm.nih.gov/pubmed/22201878

Witting PK, Song C, Hsu K, Hua S, Parry SN, Aran R, . . . Freedman SB (2011) The acute-phase protein serum amyloid A induces endothelial dysfunction that is inhibited by high-density lipoprotein. Free Radic Biol Med 51:1390-1398.
http://www.ncbi.nlm.nih.gov/pubmed/21784147

Wolthuis EK, Vlaar AP, Choi G, Roelofs JJ, Levi M, Juffermans NP, Schultz MJ (2012) Relative Tissue Factor Deficiency Attenuates Ventilator-Induced Coagulopathy but Does Not Protect against Ventilator-Induced Lung Injury in Mice. Crit Care Res Pract 2012:130410.
http://www.ncbi.nlm.nih.gov/pubmed/22195278

Young G, Shapiro AD, Walsh CE, Gruppo RA, Gut RZ, Cooper DL (2011) Patient/Caregiver-reported recombinant factor VIIa (rFVIIa) dosing: home treatment of acute bleeds in the Dosing Observational Study in Hemophilia (DOSE). Haemophilia.
http://www.ncbi.nlm.nih.gov/pubmed/22171621

Zhang Q, Zhang Y, Wang SZ, Wang N, Jiang WG, Ji YH, Zhang SL (2012) Reduced expression of Tissue factor pathway inhibitor-2 contributes to apoptosis and angiogenesis in cervical cancer. J Exp Clin Cancer Res 31:1.
http://www.ncbi.nlm.nih.gov/pubmed/22208663

Zhou Q, Xiong Y, Cheng Y, Du Y, Zhang J, Mu J, . . . Li X (2011) Effects of Tissue Factor Pathway Inhibitor-2 Expression on Biological Behavior of BeWo and JEG-3 Cell Lines. Clin Appl Thromb Hemost.
http://www.ncbi.nlm.nih.gov/pubmed/22203034
__________________________________________________________

Vol. 17, No. 24

noreply@blogger.com (Pierre) — Thu, 15 Dec 2011 20:13:00 +0000

TRIGGER
The Twice-Monthly Electronic Newsletter on the Biology of Tissue Factor, Factor VII and TFPI
Vol. 17, No. 24 December 15, 2011

(The next issue will be on January 2, 2012)

__________________________________________________________
TRIGGER is also available by RSS Feed:

http://feeds.feedburner.com/blogspot/glro

and BLOG:
http://trigger-tf7.blogspot.com/
__________________________________________________________
ANNOUNCEMENTS
Our best holiday wishes to all the TRIGGER subscribers for a happy, healthy and prosperous New Year!

-Jim & Genie Morrissey and Pierre Neuenschwander
__________________________________________________________
PAPERS IN PRESS
None submitted for this issue.
__________________________________________________________
UPCOMING MEETINGS & EVENTS
The meeting brochure and online registration for the upcoming "6th Symposium on Hemostasis with Special Focus on Tissue Factor, Factor VIIa and Tissue Factor Pathway Inhibitor-- Hemostasis and Beyond" are now available at:
http://medicine.med.unc.edu/hemonc/tf2012
The meeting will be held on 3-5 May 2012, at the Carolina Inn, Chapel Hill NC, USA.
__________________________________________________________
RECENT PUBLICATIONS ON TISSUE FACTOR, FACTOR VII, AND TFPI

THE FOLLOWING LINK WILL TAKE YOU TO THE ENTIRE LIST OF THIS ISSUE'S PUBLICATIONS IN A PUBMED "COLLECTION":
http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/1jme8kBYm8u5kkri2b58UN-/

Binny C, McIntosh J, Della Peruta M, Kymalainen H, Tuddenham EG, Buckley SM, . . . Nathwani AC (2011) AAV-mediated gene transfer in the perinatal period results in expression of FVII at levels that protect against fatal spontaneous haemorrhage. Blood.
http://www.ncbi.nlm.nih.gov/pubmed/22134170

Brophy DF, Martin EJ, Barrett JC, Nolte ME, Kuhn JG, Hedner U, Ezban M (2011) Overcoming delayed in-vitro response to rFVIIa: effects of rFVIIa and rFVIIa analogue (vatreptacog alfa) concentration escalation in whole blood assays. Blood Coagul Fibrinolysis 22:541-546.
http://www.ncbi.nlm.nih.gov/pubmed/21681082

Brophy DF, Martin EJ, Christian Barrett J, Nolte ME, Kuhn JG, Gerk PM, . . . Hedner U (2011) Monitoring rFVIIa 90 mug kg(1) dosing in haemophiliacs: comparing laboratory response using various whole blood assays over 6 h. Haemophilia 17:e949-957.
http://www.ncbi.nlm.nih.gov/pubmed/21362113

Camire RM (2011) A new look at blood coagulation factor V. Curr Opin Hematol 18:338-342.
http://www.ncbi.nlm.nih.gov/pubmed/21730834

Carlsson K, Persson E, Lindgren M, Carlsson U, Svensson M (2011) Effects on the conformation of FVIIa by sTF and Ca(2) binding: studies of fluorescence resonance energy transfer and quenching. Biochem Biophys Res Commun 413:545-549.
http://www.ncbi.nlm.nih.gov/pubmed/21924243

Chavez-Tapia NC, Alfaro-Lara R, Tellez-Avila F, Barrientos-Gutierrez T, Gonzalez-Chon O, Mendez-Sanchez N, Uribe M (2011) Prophylactic activated recombinant factor VII in liver resection and liver transplantation: systematic review and meta-analysis. PLoS One 6:e22581.
http://www.ncbi.nlm.nih.gov/pubmed/21818342

Cocco E, Varughese J, Buza N, Bellone S, Lin KY, Bellone M, . . . Santin AD (2011) Tissue factor expression in ovarian cancer: implications for immunotherapy with hI-con1, a factor VII-IgGF(c) chimeric protein targeting tissue factor. Clin Exp Metastasis 28:689-700.
http://www.ncbi.nlm.nih.gov/pubmed/21725665

Collins PW (2011) Management of acquired haemophilia A. J Thromb Haemost 9 Suppl 1:226-235.
http://www.ncbi.nlm.nih.gov/pubmed/21781259

Cui MZ (2011) Lysophosphatidic acid effects on atherosclerosis and thrombosis. Clin Lipidol 6:413-426.
http://www.ncbi.nlm.nih.gov/pubmed/22162980

Egorina EM, Sovershaev MA, Hansen JB (2011) The role of tissue factor in systemic inflammatory response syndrome. Blood Coagul Fibrinolysis 22:451-456.
http://www.ncbi.nlm.nih.gov/pubmed/21597365

Esmon CT, Xu J, Lupu F (2011) Innate immunity and coagulation. J Thromb Haemost 9 Suppl 1:182-188.
http://www.ncbi.nlm.nih.gov/pubmed/21781254

Girard TJ, Tuley E, Broze GJ, Jr. (2011) TFPIbeta is the GPI-anchored TFPI isoform on human endothelial cells and placental microsomes. Blood.
http://www.ncbi.nlm.nih.gov/pubmed/22144186

Gurusamy KS, Pissanou T, Pikhart H, Vaughan J, Burroughs AK, Davidson BR (2011) Methods to decrease blood loss and transfusion requirements for liver transplantation. Cochrane Database Syst Rev 12:CD009052.
http://www.ncbi.nlm.nih.gov/pubmed/22161443

Hay JW, Zhou ZY (2011) Economical comparison of APCC vs. rFVIIa for mild-to-moderate bleeding episodes in haemophilia patients with inhibitors. Haemophilia 17:e969-974.
http://www.ncbi.nlm.nih.gov/pubmed/21649802

Hibi K, Goto T, Shirahata A, Saito M, Kigawa G, Nemoto H, Sanada Y (2011) Detection of TFPI2 methylation in the serum of colorectal cancer patients. Cancer Lett 311:96-100.
http://www.ncbi.nlm.nih.gov/pubmed/21820798

Hoshi A, Matsumoto A, Chung J, Isozumi Y, Koyama T (2011) Activation of coagulation by a thalidomide-based regimen. Blood Coagul Fibrinolysis 22:532-540.
http://www.ncbi.nlm.nih.gov/pubmed/21670663

Hwang SM, Kim JE, Han KS, Kim HK (2011) Thrombomodulin phenotype of a distinct monocyte subtype is an independent prognostic marker for disseminated intravascular coagulation. Crit Care 15:R113.
http://www.ncbi.nlm.nih.gov/pubmed/21489300

Ingerslev J, Sorensen B (2011) Parallel use of by-passing agents in haemophilia with inhibitors: a critical review. Br J Haematol 155:256-262.
http://www.ncbi.nlm.nih.gov/pubmed/21895627

Kakko T, Jaakkola U, Raitakari OT, Kallio J (2011) Inflammatory effects of blood leukocytes: association with vascular function in neuropeptide Y proline 7-genotyped type 2 diabetes patients. Diab Vasc Dis Res 8:221-228.
http://www.ncbi.nlm.nih.gov/pubmed/21746772

Kayem G, Kurinczuk JJ, Alfirevic Z, Spark P, Brocklehurst P, Knight M (2011) Specific second-line therapies for postpartum haemorrhage: a national cohort study. BJOG 118:856-864.
http://www.ncbi.nlm.nih.gov/pubmed/21392247

Kim WJ, Oh JY, Son HJ, Chin JH, Choi DK, Lee EH, . . . Choi IC (2011) The prophylactic use of recombinant factor VIIa in a patient with DeBakey type III aortic dissection -A case report. Korean J Anesthesiol 61:431-434.
http://www.ncbi.nlm.nih.gov/pubmed/22148094

Knudsen T, Kjalke M, Tranholm M, Nichols TC, Jensen AL, Kristensen AT (2011) Development of a flow cytometric assay for detection of coated platelets in dogs and evaluation of binding of coated platelets to recombinant human coagulation factor VIIa. Am J Vet Res 72:1007-1014.
http://www.ncbi.nlm.nih.gov/pubmed/21801056

Kobayashi T, Nakabayashi M, Yoshioka A, Maeda M, Ikenoue T (2011) Recombinant activated factor VII (rFVIIa/NovoSeven((R))) in the management of severe postpartum haemorrhage: initial report of a multicentre case series in Japan. Int J Hematol.
http://www.ncbi.nlm.nih.gov/pubmed/22160834

Krijnen PA, Hahn NE, Kholova I, Baylan U, Sipkens JA, van Alphen FP, . . . Niessen HW (2012) Loss of DPP4 activity is related to a prothrombogenic status of endothelial cells: implications for the coronary microvasculature of myocardial infarction patients. Basic Res Cardiol 107:1-13.
http://www.ncbi.nlm.nih.gov/pubmed/22167343

Kruthika-Vinod TP, Nagaraja D, Christopher R (2011) Coagulation factor VII R353Q polymorphism and the risk of puerperal cerebral venous thrombosis. J Clin Neurosci.
http://www.ncbi.nlm.nih.gov/pubmed/22136731

Krysiak R, Gdula-Dymek A, Okopien B (2011) Hemostatic effects of bezafibrate and omega-3 fatty acids in isolated hypertriglyceridemic patients. Pharmacol Rep 63:763-771.
http://www.ncbi.nlm.nih.gov/pubmed/21857087

Latchamsetty R, Gautam S, Bhakta D, Chugh A, John RM, Epstein LM, . . . Jongnarangsin K (2011) Management and outcomes of cardiac tamponade during atrial fibrillation ablation in the presence of therapeutic anticoagulation with warfarin. Heart Rhythm 8:805-808.
http://www.ncbi.nlm.nih.gov/pubmed/21236362

Lemon SJ, Jr., Crannage AJ (2011) Pharmacologic anticoagulation reversal in the emergency department. Adv Emerg Nurs J 33:212-223; quiz 224-215.
http://www.ncbi.nlm.nih.gov/pubmed/21836448

Li J, Liu Y, Yin W, Zhang C, Huang J, Liao C, . . . Xiao P (2011) Alterations of the preoperative coagulation profile in patients with acute appendicitis. Clin Chem Lab Med 49:1333-1339.
http://www.ncbi.nlm.nih.gov/pubmed/21663567

Lisman T, Porte RJ (2011) Recombinant factor VIIa to treat severe bleeding in patients with liver disease: pitfalls and possibilities. J Hepatol 55:950-951.
http://www.ncbi.nlm.nih.gov/pubmed/21925325

Liu Y, Jiang P, Capkova K, Xue D, Ye L, Sinha SC, . . . Liu C (2011) Tissue factor-activated coagulation cascade in the tumor microenvironment is critical for tumor progression and an effective target for therapy. Cancer Res 71:6492-6502.
http://www.ncbi.nlm.nih.gov/pubmed/21880589

Luszczak J, Undas A, Gissel M, Olszowska M, Butenas S (2011) Activated factor XI and tissue factor in aortic stenosis: links with thrombin generation. Blood Coagul Fibrinolysis 22:473-479.
http://www.ncbi.nlm.nih.gov/pubmed/21519234

Mayne E, Funderburg NT, Sieg SF, Asaad R, Kalinowska M, Rodriguez B, . . . Lederman MM (2011) Increased platelet and microparticle activation in HIV infection: upregulation of P-selectin and tissue factor expression. J Acquir Immune Defic Syndr.
http://www.ncbi.nlm.nih.gov/pubmed/22156911

Meisel SR, Xu XP, Edgington TS, Cercek B, Ong J, Kaul S, Shah PK (2011) Dose-dependent modulation of tissue factor protein and procoagulant activity in human monocyte-derived macrophages by oxidized low density lipoprotein. J Atheroscler Thromb 18:596-603.
http://www.ncbi.nlm.nih.gov/pubmed/21467727

Milligan C, Higginson I, Smith JE (2011) Emergency department staff knowledge of massive transfusion for trauma: the need for an evidence based protocol. Emerg Med J 28:870-872.
http://www.ncbi.nlm.nih.gov/pubmed/21030544

Paluszkiewicz P, Mayzner-Zawadzka E, Baranowski W, Breborowicz GH, Brzezinski M, Durek G, . . . Wujtewicz M (2011) Recommendations for the management of trauma or surgery-related massive blood loss. Pol Przegl Chir 83:465-476.
http://www.ncbi.nlm.nih.gov/pubmed/22166722

Park JB, Kim BK, Kwon YW, Muller DN, Lee HC, Youn SW, . . . Kim HS (2011) Peroxisome proliferator-activated receptor-gamma agonists suppress tissue factor overexpression in rat balloon injury model with Paclitaxel infusion. PLoS One 6:e28327.
http://www.ncbi.nlm.nih.gov/pubmed/22140576

Patanwala AE, Acquisto NM, Erstad BL (2011) Prothrombin complex concentrate for critical bleeding. Ann Pharmacother 45:990-999.
http://www.ncbi.nlm.nih.gov/pubmed/21730276

Peled E, Rovitsky A, Axelman E, Norman D, Brenner B, Nadir Y (2011) Increased heparanase level and procoagulant activity in orthopedic surgery patients receiving prophylactic dose of enoxaparin. Thromb Res.
http://www.ncbi.nlm.nih.gov/pubmed/22154361

Quezada M, Diaz J, Henriquez S, Bravo ML, Aranda E, Oliva B, . . . Owen GI (2010) 2-Methoxyestradiol inhibits progesterone-dependent tissue factor expression and activity in breast cancer cells. Horm Cancer 1:117-126.
http://www.ncbi.nlm.nih.gov/pubmed/21761355

Rasekh HR, Imani A, Karimi M, Golestani M (2011) Cost-utility analysis of immune tolerance induction therapy versus on-demand treatment with recombinant factor VII for hemophilia A with high titer inhibitors in Iran. Clinicoecon Outcomes Res 3:207-212.
http://www.ncbi.nlm.nih.gov/pubmed/22163168

Ruf W, Disse J, Carneiro-Lobo TC, Yokota N, Schaffner F (2011) Tissue factor and cell signalling in cancer progression and thrombosis. J Thromb Haemost 9 Suppl 1:306-315.
http://www.ncbi.nlm.nih.gov/pubmed/21781267

Saito Y, Hashimoto Y, Kuroda J, Yasunaga M, Koga Y, Takahashi A, Matsumura Y (2011) The inhibition of pancreatic cancer invasion-metastasis cascade in both cellular signal and blood coagulation cascade of tissue factor by its neutralisation antibody. Eur J Cancer 47:2230-2239.
http://www.ncbi.nlm.nih.gov/pubmed/21621407

Sangha N, Gonzales NR (2011) Treatment targets in intracerebral hemorrhage. Neurotherapeutics 8:374-387.
http://www.ncbi.nlm.nih.gov/pubmed/21732225

Sartori MT, Della Puppa A, Ballin A, Saggiorato G, Bernardi D, Padoan A, . . . Cella G (2011) Prothrombotic state in glioblastoma multiforme: an evaluation of the procoagulant activity of circulating microparticles. J Neurooncol 104:225-231.
http://www.ncbi.nlm.nih.gov/pubmed/21104297

Schmid D, Svoboda M, Sorgner A, Moravcevic I, Thalhammer T, Chiba P, Moslinger T (2011) Glibenclamide reduces proinflammatory cytokines in an ex vivo model of human endotoxinaemia under hypoxaemic conditions. Life Sci 89:725-734.
http://www.ncbi.nlm.nih.gov/pubmed/21925514

Schmid P, Mordasini A, Luginbuhl M, Regli B, Kohler HP, Zimmermann H, . . . Alberio L (2011) Low-dose recombinant factor VIIa for massive bleeding: a single centre observational cohort study with 73 patients. Swiss Med Wkly 141:w13213.
http://www.ncbi.nlm.nih.gov/pubmed/21735365

Shander A, Walsh CE, Cromwell C (2011) Acquired hemophilia: a rare but life-threatening potential cause of bleeding in the intensive care unit. Intensive Care Med 37:1240-1249.
http://www.ncbi.nlm.nih.gov/pubmed/21626430

Siddiq S, Clark A, Mumford A (2011) A systematic review of the management and outcomes of pregnancy in Glanzmann thrombasthenia. Haemophilia 17:e858-869.
http://www.ncbi.nlm.nih.gov/pubmed/21457404

Sie P, Samama CM, Godier A, Rosencher N, Steib A, Llau JV, . . . Albaladejo P (2011) Surgery and invasive procedures in patients on long-term treatment with direct oral anticoagulants: Thrombin or factor-Xa inhibitors. Recommendations of the Working Group on perioperative haemostasis and the French Study Group on thrombosis and haemostasis. Arch Cardiovasc Dis 104:669-676.
http://www.ncbi.nlm.nih.gov/pubmed/22152517

Sorour Y, Van Veen JJ, Makris M (2010) Recombinant factor VIIa for unlicensed indications--a definite No or a cautious Maybe in selected patients? Int J Clin Pract 64:1468-1471.
http://www.ncbi.nlm.nih.gov/pubmed/20722768

Stephan F, Hazelzet JA, Bulder I, Boermeester MA, van Till JO, van der Poll T, . . . Zeerleder S (2011) Activation of factor VII-activating protease in human inflammation: a sensor for cell death. Crit Care 15:R110.
http://www.ncbi.nlm.nih.gov/pubmed/21466697

Stokol T, Daddona JL, Mubayed LS, Trimpert J, Kang S (2011) Evaluation of tissue factor expression in canine tumor cells. Am J Vet Res 72:1097-1106.
http://www.ncbi.nlm.nih.gov/pubmed/21801068

Storgaard M, Henriksen ST, Zaragoza F, Peschke B, Tanner D (2011) Design, synthesis and biological activity of novel peptidyl benzyl ketone FVIIa inhibitors. Bioorg Med Chem Lett 21:3918-3922.
http://www.ncbi.nlm.nih.gov/pubmed/21641796

Takeuchi H, Fernandez-Valdivia RC, Caswell DS, Nita-Lazar A, Rana NA, Garner TP, . . . Haltiwanger RS (2011) Rumi functions as both a protein O-glucosyltransferase and a protein O-xylosyltransferase. Proc Natl Acad Sci U S A 108:16600-16605.
http://www.ncbi.nlm.nih.gov/pubmed/21949356

Tang JQ, Fan Q, Wu WH, Jia ZC, Li H, Yang YM, . . . Wan YL (2010) Extrahepatic synthesis of coagulation factor VII by colorectal cancer cells promotes tumor invasion and metastasis. Chin Med J (Engl) 123:3559-3565.
http://www.ncbi.nlm.nih.gov/pubmed/22166631

Tran HT, Tjonnfjord GE, Paus A, Holme PA (2011) rFVIIa administered by continuous infusion during surgery in patients with severe congenital FVII deficiency. Haemophilia 17:764-770.
http://www.ncbi.nlm.nih.gov/pubmed/21707871

van den Hengel LG, Kocaturk B, Reitsma PH, Ruf W, Versteeg HH (2011) Complete abolishment of coagulant activity in monomeric disulfide-deficient tissue factor. Blood 118:3446-3448.
http://www.ncbi.nlm.nih.gov/pubmed/21940832

Vang ML, Hvas AM, Ravn HB (2011) Urgent reversal of vitamin K antagonist therapy. Acta Anaesthesiol Scand 55:507-516.
http://www.ncbi.nlm.nih.gov/pubmed/21418150

Versteeg HH, Ruf W (2011) Thiol pathways in the regulation of tissue factor prothrombotic activity. Curr Opin Hematol 18:343-348.
http://www.ncbi.nlm.nih.gov/pubmed/21778880

Walsh M, Thomas SG, Howard JC, Evans E, Guyer K, Medvecz A, . . . Castellino FJ (2011) Blood component therapy in trauma guided with the utilization of the perfusionist and thromboelastography. J Extra Corpor Technol 43:162-167.
http://www.ncbi.nlm.nih.gov/pubmed/22164456

Weatherall J, Barnes N, Brown C, Preaud E (2011) Future characteristics of bypassing agents to improve care of hemophilia inhibitor patients: an economic and health-related quality of life perspective. Expert Rev Pharmacoecon Outcomes Res 11:411-414.
http://www.ncbi.nlm.nih.gov/pubmed/21831021

Wyckoff T, Reed EA, Desai ND, Augoustides JG (2011) Possible Anaphylaxis Due to Recombinant Factor VIIa Administration During Thoracic Aortic Surgery. J Cardiothorac Vasc Anesth.
http://www.ncbi.nlm.nih.gov/pubmed/22155168

Yamamoto E, Nishimura N, Okada K, Sekido C, Yamamichi S, Hasumi K (2011) Inhibitors of autoactivation of plasma hyaluronan-binding protein (factor VII activating protease). Biol Pharm Bull 34:462-470.
http://www.ncbi.nlm.nih.gov/pubmed/21467630

Young G, Auerswald G, Jimenez-Yuste V, Konkle BA, Lambert T, Morfini M, . . . Blanchette V (2011) When should prophylaxis therapy in inhibitor patients be considered? Haemophilia 17:e849-857.
http://www.ncbi.nlm.nih.gov/pubmed/21418444

Zhu J, Xie R, Piao X, Hou Y, Zhao C, Qiao G, . . . Lu Y (2011) Homocysteine enhances clot-promoting activity of endothelial cells via phosphatidylserine externalization and microparticles formation. Amino Acids.
http://www.ncbi.nlm.nih.gov/pubmed/22160264
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Vol. 17, No. 23

noreply@blogger.com (Pierre) — Mon, 12 Dec 2011 17:06:00 +0000

TRIGGER
The Twice-Monthly Electronic Newsletter on the Biology of Tissue Factor, Factor VII and TFPI
Vol. 17, No. 23 December 1, 2011

(The next issue will be on December 15, 2011)

__________________________________________________________
TRIGGER is also available by RSS Feed:

http://feeds.feedburner.com/blogspot/glro

and BLOG:
http://trigger-tf7.blogspot.com/
__________________________________________________________

POSITIONS SOUGHT/AVAILABLE
The UNC McAllister Heart Institute, in collaboration with the departments in the School of Medicine and across the entire University, seeks outstanding candidates for an open-rank position at all levels of basic/translational research. This recruitment seeks a research scientist/physician interested in cardiovascular disease, including but not limited to vascular development, angiogenesis, cardiac pathology, and thrombosis. Applicants should have a strong record of recent accomplishments as a post-doctoral fellow or sustained productivity as an established faculty member. Academic credentials and experience will determine rank, track, and salary in an appropriate academic department. Applications will be reviewed beginning November 10, 2011 and until the position is filled.

Applicants must submit a letter of interest, curriculum vitae, a description of research plans, and names of four references through UNC Chapel Hill's web-based system. PDF documents are preferred. The following link will direct you to the position:
http://jobs.unc.edu/2502018

UNC McAllister Heart Institute and the University of North Carolina is an Equal Opportunity Employer. Hiring is contingent upon eligibility to work in the United States. Women and minorities are encouraged to apply.
__________________________________________________________
PAPERS IN PRESS

None submitted for this issue.
__________________________________________________________
RECENT PUBLICATIONS ON TISSUE FACTOR, FACTOR VII, AND TFPI

THE FOLLOWING LINK WILL TAKE YOU TO THE ENTIRE LIST OF THIS ISSUE'S PUBLICATIONS IN A PUBMED "COLLECTION":
http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/1felWqyBWcGWhnjhWiipypk/

Alstrom U, Levin LA, Stahle E, Svedjeholm R, Friberg O (2011) Cost analysis of re-exploration for bleeding after coronary artery bypass graft surgery. Br J Anaesth.
http://www.ncbi.nlm.nih.gov/pubmed/22113929

Bhananker SM, Ramaiah R (2011) Trends in trauma transfusion. Int J Crit Illn Inj Sci 1:51-56.
http://www.ncbi.nlm.nih.gov/pubmed/22096774

Bouchama A, Al-Mohanna F, Assad L, Baturcam E, Eldali A, Owaidah T, Dehbi M (2011) Tissue factor/factor VIIa pathway mediates coagulation activation in induced-heat stroke in the baboon. Crit Care Med.
http://www.ncbi.nlm.nih.gov/pubmed/22080642

Busch JD, Van Andel R, Cordova J, Colman RE, Keim P, Rocke TE, . . . Wagner DM (2011) Population Differences in Host Immune Factors May Influence Survival of Gunnison's Prairie Dogs (Cynomys gunnisoni) during Plague Outbreaks. J Wildl Dis 47:968-973.
http://www.ncbi.nlm.nih.gov/pubmed/22102668

Cerletti C, Tamburrelli C, Izzi B, Gianfagna F, de Gaetano G (2011) Platelet-leukocyte interactions in thrombosis. Thromb Res.
http://www.ncbi.nlm.nih.gov/pubmed/22075180

Cheng V, Kashyap SR, Schauer PR, Kirwan JP, McCrae KR (2011) Restoration of glycemic control in patients with type 2 diabetes mellitus after bariatric surgery is associated with reduction in microparticles. Surg Obes Relat Dis.
http://www.ncbi.nlm.nih.gov/pubmed/22093380

Christensen A, Jensen JT, Nohr AM, Cooper DL (2011) Room-Temperature-Stable Coagulation Factor VII Recombinant: Chemical and Microbiologic Stability Over 24 Hours During Continuous In VitroInfusion. Clin Ther.
http://www.ncbi.nlm.nih.gov/pubmed/22088413

Comes JF, Devignes J, Thiebaugeorges O, Briquel ME, Lecompte T (2011) Prophylactic use of a recombinant activated factor VII in delivery haemorrhage by caesarean in a woman with major factor VII deficiency: a case report. Ann Biol Clin (Paris) 69:713-719.
http://www.ncbi.nlm.nih.gov/pubmed/22123573

Corlan AD, Ross J (2011) Canalization effect in the coagulation cascade and the interindividual variability of oral anticoagulant response. a simulation Study. Theor Biol Med Model 8:37.
http://www.ncbi.nlm.nih.gov/pubmed/22082142

Dirkmann D, Gorlinger K, Gisbertz C, Dusse F, Peters J (2011) Factor XIII and Tranexamic Acid But Not Recombinant Factor VIIa Attenuate Tissue Plasminogen Activator-Induced Hyperfibrinolysis in Human Whole Blood. Anesth Analg.
http://www.ncbi.nlm.nih.gov/pubmed/22104068

Egorina EM, Sovershaev TA, Hansen JB, Sovershaev MA (2011) BMP-2 inhibits TF expression in human monocytes by shutting down MAPK signaling and AP-1 transcriptional activity. Thromb Res.
http://www.ncbi.nlm.nih.gov/pubmed/22119392

Fadzil F (2011) Recurrent intracranial haemorrhages in a patient with factor seven deficiency: a case report. Med J Malaysia 66:261-263.
http://www.ncbi.nlm.nih.gov/pubmed/22111455

Francischetti IM, Oliveira CJ, Ostera GR, Yager SB, Debierre-Grockiego F, Carregaro V, . . . Waisberg M (2011) Defibrotide Interferes With Several Steps of the Coagulation-Inflammation Cycle and Exhibits Therapeutic Potential to Treat Severe Malaria. Arterioscler Thromb Vasc Biol.
http://www.ncbi.nlm.nih.gov/pubmed/22116094

Fukushima T, Mikane T, Ono D, Oku S, Kobayashi H, Watanabe Y, . . . Tokioka H (2011) A case of acquired hemophilia A with massive hemothorax. J Anesth.
http://www.ncbi.nlm.nih.gov/pubmed/22086484

Graham EM, Atz AM, Gillis J, Desantis SM, Haney AL, Deardorff RL, . . . Spinale FG (2011) Differential effects of aprotinin and tranexamic acid on outcomes and cytokine profiles in neonates undergoing cardiac surgery. J Thorac Cardiovasc Surg.
http://www.ncbi.nlm.nih.gov/pubmed/22075061

Hay JW, Zhou ZY (2011) Systematic literature review of economics analysis on treatment of mild-to-moderate bleeds with aPCC versus rFVIIa. J Med Econ 14:516-525.
http://www.ncbi.nlm.nih.gov/pubmed/21699366

Henriquez S, Calderon C, Quezada M, Oliva B, Bravo ML, Aranda E, . . . Owen GI (2011) Progesterone utilizes distinct membrane pools of tissue factor to increase coagulation and invasion and these effects are inhibited by TFPI. J Cell Physiol 226:3278-3285.
http://www.ncbi.nlm.nih.gov/pubmed/21344386

Hibi K, Goto T, Shirahata A, Saito M, Kigawa G, Nemoto H, Sanada Y (2011) Detection of TFPI2 Methylation in the Serum of Gastric Cancer Patients. Anticancer Res 31:3835-3838.
http://www.ncbi.nlm.nih.gov/pubmed/22110206

Huang J, Liu XJ, Bao HR, Zhang Y, Tan EL, Liao JM (2011) [The relationship between coagulation/anticoagulation imbalance and oxidative stress in patients with chronic obstructive pulmonary disease]. Zhonghua Nei Ke Za Zhi 50:664-667.
http://www.ncbi.nlm.nih.gov/pubmed/22093558

Jia ZC, Wan YL, Tang JQ, Dai Y, Liu YC, Wang X, Zhu J (2011) Tissue factor/activated factor VIIa induces matrix metalloproteinase-7 expression through activation of c-Fos via ERK1/2 and p38 MAPK signaling pathways in human colon cancer cell. Int J Colorectal Dis.
http://www.ncbi.nlm.nih.gov/pubmed/22076613

Kanse SM, Declerck PJ, Ruf W, Broze G, Etscheid M (2011) Factor VII-Activating Protease Promotes the Proteolysis and Inhibition of Tissue Factor Pathway Inhibitor. Arterioscler Thromb Vasc Biol.
http://www.ncbi.nlm.nih.gov/pubmed/22116096

Katgi A, Ataca P, Kahraman S, Piskin O, Ozcan MA, Demirkan F, . . . Undar B (2011) Ischemic stroke after recombinant factor VIIa treatment in acquired hemophilia A patient. Blood Coagul Fibrinolysis.
http://www.ncbi.nlm.nih.gov/pubmed/22123285

Khan MM, Douglas SD, Benton TD (2011) Substance P-Neurokinin-1 receptor interaction upregulates monocyte tissue factor. J Neuroimmunol.
http://www.ncbi.nlm.nih.gov/pubmed/22115773

Lee CW, Park CS, Hwang I, Lee H, Park DW, Kang SJ, . . . Park SJ (2011) Comparison of ruptured coronary plaques in patients with unstable and stable clinical presentation. J Thromb Thrombolysis 32:150-157.
http://www.ncbi.nlm.nih.gov/pubmed/21505786

Lorenzet R, Napoleone E, Cutrone A, Donati MB (2011) Thrombosis and obesity: Cellular bases. Thromb Res.
http://www.ncbi.nlm.nih.gov/pubmed/22078462

Machado GB, de Oliveira AV, Saliba AM, de Lima CD, Suassuna JH, Plotkowski MC (2011) Pseudomonas aeruginosa toxin ExoU induces a PAF-dependent impairment of alveolar fibrin turnover secondary to enhanced activation of coagulation and increased expression of plasminogen activator inhibitor-1 in the course of mice pneumosepsis. Respir Res 12:104.
http://www.ncbi.nlm.nih.gov/pubmed/21819560

Mischke R (2011) Determination of canine coagulation factor VII. Vet J 190:305-306.
http://www.ncbi.nlm.nih.gov/pubmed/22108258

Morse BC, Dente CJ, Hodgman EI, Shaz BH, Nicholas JM, Wyrzykowski AD, . . . Feliciano DV (2011) The effects of protocolized use of recombinant factor VIIa within a massive transfusion protocol in a civilian level I trauma center. Am Surg 77:1043-1049.
http://www.ncbi.nlm.nih.gov/pubmed/21944521

Mu E, Chen S, Li X, Ma XC (2011) [The effect of factor VII activating protease treatment on proliferation and collagen synthesis of cultured human pulmonary fibroblasts]. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 23:653-657.
http://www.ncbi.nlm.nih.gov/pubmed/22093309

Nakagomi A, Sasaki M, Ishikawa Y, Shibui T, Kosugi M, Endoh Y, . . . Mizuno K (2011) Upregulation of monocyte tissue factor activity is significantly associated with carotid intima-media thickness in patients with metabolic syndrome. J Atheroscler Thromb 18:475-486.
http://www.ncbi.nlm.nih.gov/pubmed/21483174

Orfeo T, Gissel M, Butenas S, Undas A, Brummel-Ziedins KE, Mann KG (2011) Anticoagulants and the propagation phase of thrombin generation. PLoS One 6:e27852.
http://www.ncbi.nlm.nih.gov/pubmed/22125631

Palojarvi A, Andersson S, Siitonen S, Janer C, Petaja J (2011) High tissue factor in lungs and plasma associates with respiratory morbidity in preterm infants. Acta Paediatr.
http://www.ncbi.nlm.nih.gov/pubmed/22107344

Pierfranceschi MG, Imberti D, Orlando S, Vallisa D, Michieletti E (2011) Effectiveness of recombinant activated factor VII in haemorragic cancer-related disseminated intravascular coagulation: a case report. Blood Transfus 9:336-338.
http://www.ncbi.nlm.nih.gov/pubmed/21251460

Poller L, Ibrahim S, Pattison A, Jespersen J (2011) INR derivation with the PT/INR Line simplified using a spreadsheet from the world wide web. J Clin Pathol 64:930-932.
http://www.ncbi.nlm.nih.gov/pubmed/21515693

Poursafa P, Kelishadi R, Moattar F, Rafiee L, Amin MM, Lahijanzadeh A, Javanmard SH (2011) Genetic variation in the association of air pollutants with a biomarker of vascular injury in children and adolescents in Isfahan, Iran. J Res Med Sci 16:733-740.
http://www.ncbi.nlm.nih.gov/pubmed/22091301

Pugh N, Jarvis GE, Koch A, Sakariassen KS, Davis B, Farndale RW (2011) The impact of factor Xa inhibition on axial dependent arterial thrombus formation triggered by a tissue factor rich surface. J Thromb Thrombolysis.
http://www.ncbi.nlm.nih.gov/pubmed/22120925

Sen P, Nayak R, Clark CA, Gopalakrishnan R, Esmon CT, Pendurthi UR, Rao LV (2011) Factor X binding to endothelial cell protein C receptor: comparison with factor VIIa and activated protein C. Blood 118:2635-2636.
http://www.ncbi.nlm.nih.gov/pubmed/21885613

Shimizu A, Yamada K, Robson SC, Sachs DH, Colvin RB (2011) Pathologic Characteristics of Transplanted Kidney Xenografts. J Am Soc Nephrol.
http://www.ncbi.nlm.nih.gov/pubmed/22114174

Su LL, Chong YS (2011) Massive obstetric haemorrhage with disseminated intravascular coagulopathy. Best Pract Res Clin Obstet Gynaecol.
http://www.ncbi.nlm.nih.gov/pubmed/22101177

Sun Q, Chen L, Gao M, Jiang W, Shao F, Li J, . . . Yu B (2011) Ruscogenin inhibits lipopolysaccharide-induced acute lung injury in mice: Involvement of tissue factor, inducible NO synthase and nuclear factor (NF)-kappaB. Int Immunopharmacol.
http://www.ncbi.nlm.nih.gov/pubmed/22079591

Tan CW, Najm J, Morel-Kopp MC, Teo J, Chen Q, Felbor U, Ward CM (2011) Severe FX deficiency caused by a previously unidentified 4-bp deletion compound heterozygous with a large deletion involving FVII and FX genes. Haemophilia.
http://www.ncbi.nlm.nih.gov/pubmed/22126652

Tarzia V, Bottio T, Buratto E, Spiezia L, Simioni P, Gerosa G (2011) The hazard of comparing apples and oranges: The proper indication for the use of recombinant activated clotting factor VII in cardiac surgery. J Thorac Cardiovasc Surg 142:1588-1589.
http://www.ncbi.nlm.nih.gov/pubmed/22093717

Wilson JX, Wu F (2012) Vitamin C in sepsis. Subcell Biochem 56:67-83.
http://www.ncbi.nlm.nih.gov/pubmed/22116695

Wolberg AS, Aleman MM, Leiderman K, Machlus KR (2011) Procoagulant Activity in Hemostasis and Thrombosis: Virchow's Triad Revisited. Anesth Analg.
http://www.ncbi.nlm.nih.gov/pubmed/22104070

Ye R, Ye C, Huang Y, Liu L, Wang S (2011) Circulating tissue factor positive microparticles in patients with acute recurrent deep venous thrombosis. Thromb Res.
http://www.ncbi.nlm.nih.gov/pubmed/22099707

Zhang Q, Liu XJ, Hu L, Liao DS, Zheng YB, Zhen YS, Song X (2011) Factor VII light chain-targeted lidamycin targets tissue factor-overexpressing tumor cells for cancer therapy. Int J Mol Med.
http://www.ncbi.nlm.nih.gov/pubmed/22108624

Zheng F, Jin Y, Wang M, Niu Z, Xu P, Xie H (2011) Congenital combined deficiency of factor VII and X in a patient due to accidental diphacinone intoxication. Thromb Haemost 106:180-181.
http://www.ncbi.nlm.nih.gov/pubmed/21544315

Zhou F, Zhou H, Wang T, Mu Y, Wu B, Guo DL, . . . Wu Y (2011) Epigallocatechin-3-gallate inhibits proliferation and migration of human colon cancer SW620 cells in vitro. Acta Pharmacol Sin.
http://www.ncbi.nlm.nih.gov/pubmed/22101170
__________________________________________________________

Vol. 17, No. 22

noreply@blogger.com (Pierre) — Mon, 14 Nov 2011 20:18:00 +0000

TRIGGER
The Twice-Monthly Electronic Newsletter on the Biology of Tissue Factor, Factor VII and TFPI
Vol. 17, No. 22 November 15, 2011

(The next issue will be on December 1, 2011)

__________________________________________________________
TRIGGER is also available by RSS Feed:

http://feeds.feedburner.com/blogspot/glro

and BLOG:
http://trigger-tf7.blogspot.com/
__________________________________________________________

ANNOUNCEMENTS
PODCASTS FROM XXIIIrd ISTH CONGRESS
Selected talks from this summer's ISTH Congress in Kyoto are now available as webcasts (apparently open only to ISTH members) from:
http://www.multiwebcast.com/isth/2011/kyoto

The presentations can also be accessed through the"TALKS on the GO" iPhone/iPad/iPod Webcast App. Visit:
http://www.talksonthego.com/
or download it through the App Store by doing a search for: Talks on the Go (Latest version 1.1.0 of the Application approved by Apple Inc. on July 14th features an advanced Search Engine giving results by relevance according to slide content).
__________________________________________________________
PAPERS IN PRESS

None submitted for this issue.
__________________________________________________________
RECENT PUBLICATIONS ON TISSUE FACTOR, FACTOR VII, AND TFPI

THE FOLLOWING LINK WILL TAKE YOU TO THE ENTIRE LIST OF THIS ISSUE'S PUBLICATIONS IN A PUBMED "COLLECTION":
http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/1DASuMz6ItibCo-YOGCD8JG/

(2011) Obesity: Inhibition of tissue factor signaling-new antiobesity target? Nat Rev Endocrinol.
http://www.ncbi.nlm.nih.gov/pubmed/22064499

Altmae S, Salumets A, Bjuresten K, Kallak TK, Wanggren K, Landgren BM, . . . Stavreus-Evers A (2011) Tissue factor and tissue factor pathway inhibitors TFPI and TFPI2 in human secretory endometrium--possible link to female infertility. Reprod Sci 18:666-678.
http://www.ncbi.nlm.nih.gov/pubmed/21421890

Cheng S, Jiang Z, Zou Y, Chen C, Wang Y, Liu Y, . . . Wang Z (2011) Downregulation of Clock in circulatory system leads to an enhancement of fibrinolysis in mice. Exp Biol Med (Maywood) 236:1078-1084.
http://www.ncbi.nlm.nih.gov/pubmed/21750017

Dahab AA, Aburass R, Shawkat W, Babgi R, Essa O, Mujallid RH (2011) Full-term extrauterine abdominal pregnancy: a case report. J Med Case Reports 5:531.
http://www.ncbi.nlm.nih.gov/pubmed/22040324

Emmerechts J, Jacobs L, Van Kerckhoven S, Loyen S, Mathieu C, Fierens F, . . . Hoylaerts MF (2011) Air Pollution-Associated Procoagulant Changes: role of Circulating Microvesicles. J Thromb Haemost.
http://www.ncbi.nlm.nih.gov/pubmed/22066779

Evangelho JS, Casali KR, Campos C, De Angelis K, Veiga AB, Rigatto K
(2011) Hypercholesterolemia magnitude increases sympathetic modulation and coagulation in LDLr knockout mice. Auton Neurosci 159:98-103.
http://www.ncbi.nlm.nih.gov/pubmed/20719578

Ferrari L, Podda GM (2011) Off-label use of recombinant activated coagulation factor VII for bleeding may raise the risk of arterial thrombosis. Intern Emerg Med 6:261-262.
http://www.ncbi.nlm.nih.gov/pubmed/21541718

Godier A, Miclot A, Le Bonniec B, Durand M, Fischer AM, Emmerich J, . . . Samama CM (2011) Evaluation of Prothrombin Complex Concentrate and Recombinant Activated Factor VII to Reverse Rivaroxaban in a Rabbit Model. Anesthesiology.
http://www.ncbi.nlm.nih.gov/pubmed/22042412

Hayanga AJ (2011) Off-label use of recombinant factor VIIa. Ann Intern Med 155:337-338; author reply 338-339.
http://www.ncbi.nlm.nih.gov/pubmed/21893632

Horowitz NA, Blevins EA, Miller WM, Perry AR, Talmage KE, Mullins ES, . . . Palumbo JS (2011) Thrombomodulin is a determinant of metastasis through a mechanism linked to the thrombin binding domain but not the lectin-like domain. Blood 118:2889-2895.
http://www.ncbi.nlm.nih.gov/pubmed/21788337

Jian P, Yan WS, Chao SL, Liang P, Zhen L, Ling QB, . . . Jian N (2011) Promoter of TFPI-2 is Hypermethylated in Chinese Pediatric Acute Myeloid Leukemia. J Pediatr Hematol Oncol.
http://www.ncbi.nlm.nih.gov/pubmed/22052167

Jordan SW, Chaikof EL (2011) Simulated surface-induced thrombin generation in a flow field. Biophys J 101:276-286.
http://www.ncbi.nlm.nih.gov/pubmed/21767479

Karkouti K, Levy JH (2011) A hemorrhage of off-label use. Ann Intern Med 155:339; author reply 339-340.
http://www.ncbi.nlm.nih.gov/pubmed/21893634

Kung CW, Lee YM, Yen MH (2011) In vivo anticoagulant effect of ethyl pyruvate in endotoxemic rats. Thromb Res 127:582-588.
http://www.ncbi.nlm.nih.gov/pubmed/21396682

Mlynarsky L, Bejarano-Achache I, Muszkat M, Caraco Y (2011) Factor VII R353Q genetic polymorphism is associated with altered warfarin sensitivity among CYP2C9 *1/*1 carriers. Eur J Clin Pharmacol.
http://www.ncbi.nlm.nih.gov/pubmed/22071881

Monteiro RQ (2011) Tissue factor as a target for the treatment of disseminated intravascular coagulation. Thromb Res 127:495-496.
http://www.ncbi.nlm.nih.gov/pubmed/21531009

Nascimento B, Lin Y, Callum J, Reis M, Pinto R, Rizoli S (2011) Recombinant factor VIIa is associated with an improved 24-hour survival without an improvement in inpatient survival in massively transfused civilian trauma patients. Clinics (Sao Paulo) 66:101-106.
http://www.ncbi.nlm.nih.gov/pubmed/21437444

Petrillo G, Cirillo P, D'Ascoli GL, Maresca F, Ziviello F, Chiariello M (2010) Tissue Factor/Factor FVII Complex Inhibitors in Cardiovascular Disease. Are Things Going Well? Curr Cardiol Rev 6:325-332.
http://www.ncbi.nlm.nih.gov/pubmed/22043208

Phillips A (2011) Off-label use of recombinant factor VIIa. Ann Intern Med 155:337; author reply 338-339.
http://www.ncbi.nlm.nih.gov/pubmed/21893633

Schweintzger S, Schlagenhauf A, Leschnik B, Rinner B, Bernhard H, Novak M, Muntean W (2011) Microparticles in newborn cord blood: slight elevation after normal delivery. Thromb Res 128:62-67.
http://www.ncbi.nlm.nih.gov/pubmed/21376371

Tian M, Wan Y, Tang J, Li H, Yu G, Zhu J, . . . Zhu S (2011) Depletion of tissue factor suppresses hepatic metastasis and tumor growth in colorectal cancer via the downregulation of MMPs and the induction of autophagy and apoptosis. Cancer Biol Ther 12.
http://www.ncbi.nlm.nih.gov/pubmed/22052255

Tormoen GW, Rugonyi S, Gruber A, McCarty OJ (2011) The role of carrier number on the procoagulant activity of tissue factor in blood and plasma. Phys Biol 8:066005.
http://www.ncbi.nlm.nih.gov/pubmed/22048420

van den Berg YW, Osanto S, Reitsma PH, Versteeg HH (2011) The relationship between tissue factor and cancer progression: insights from bench and bedside. Blood.
http://www.ncbi.nlm.nih.gov/pubmed/22065595

van den Hengel LG, van den Berg YW, Reitsma PH, Bos MH, Versteeg HH (2011) Evolutionary Conservation of the Tissue Factor Disulfide Bonds and Identification of a Possible Oxidoreductase Binding Motif. J Thromb Haemost.
http://www.ncbi.nlm.nih.gov/pubmed/22066736

Zahra S, Anderson JA, Stirling D, Ludlam CA (2011) Plasma microparticles are not elevated in fresh plasma from patients with gynaecological malignancy--an observational study. Gynecol Oncol 123:152-156.
http://www.ncbi.nlm.nih.gov/pubmed/21777967

Zhang N, Lawrence DA (2011) Tissue factor and obesity, a two-way street. Nat Med 17:1343-1344.
http://www.ncbi.nlm.nih.gov/pubmed/22064407

Zhou RF, Liu Y, Wang YX, Mo W, Yu M (2011) Coagulation factor III (tissue factor) is required for vascularization in zebrafish embryos. Genet Mol Res 10.
http://www.ncbi.nlm.nih.gov/pubmed/22057990

Zhuang JL, Jiang QW, Xu Y, Wang SJ (2011) Recombinant activated factor VII in hemophagocytic lymphohistiocytosis with disseminated intravascular coagulation. Chin Med J (Engl) 124:3189-3191.
http://www.ncbi.nlm.nih.gov/pubmed/22040579
__________________________________________________________

Vol. 17, No. 21

noreply@blogger.com (Pierre) — Tue, 01 Nov 2011 21:18:00 +0000

TRIGGER
The Twice-Monthly Electronic Newsletter on the Biology of Tissue Factor, Factor VII and TFPI
Vol. 17, No. 21 November 1, 2011

(The next issue will be on November 15, 2011)

__________________________________________________________
TRIGGER is also available by RSS Feed:

http://feeds.feedburner.com/blogspot/glro

and BLOG:
http://trigger-tf7.blogspot.com/
__________________________________________________________

PAPERS IN PRESS

None submitted for this issue.
__________________________________________________________
UPCOMING MEETINGS & EVENTS
The 6th International Conference on Thrombosis and Hemostasis Issues in Cancer will be held in Bergamo, Italy, April 20-22, 2012. Online registration and abstract submission is now available. The abstract submission deadline is November 30th, 2011. For more information and to see the preliminary program, go to:
http://www.icthic.com/

* * * * * * * * * * *
Save the date:
6th Symposium on Hemostasis with Special Focus on Factor VIIa and Tissue Factor -- Hemostasis and Beyond will be held at the Carolina Inn, Chapel Hill, NC May 3-5, 2012. The link to the brochure and registration form should be available in December.
__________________________________________________________
RECENT PUBLICATIONS ON TISSUE FACTOR, FACTOR VII, AND TFPI

THE FOLLOWING LINK WILL TAKE YOU TO THE ENTIRE LIST OF THIS ISSUE'S PUBLICATIONS IN A PUBMED "COLLECTION":
http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/1TmEifV2v36Aj7jVbb-dCua/

Badeanlou L, Furlan-Freguia C, Yang G, Ruf W, Samad F (2011) Tissue factor-protease-activated receptor 2 signaling promotes diet-induced obesity and adipose inflammation. Nat Med.
http://www.ncbi.nlm.nih.gov/pubmed/22019885

Balandina AN, Shibeko AM, Kireev DA, Novikova AA, Shmirev, II, Panteleev MA, Ataullakhanov FI (2011) Positive Feedback Loops for Factor V and Factor VII Activation Supply Sensitivity to Local Surface Tissue Factor Density During Blood Coagulation. Biophys J 101:1816-1824.
http://www.ncbi.nlm.nih.gov/pubmed/22004734

Benlakhal F, Mura T, Schved JF, Giansily-Blaizot M (2011) A retrospective analysis of 157 surgical procedures performed without replacement therapy in 83 unrelated factor VII-deficient patients. J Thromb Haemost 9:1149-1156.
http://www.ncbi.nlm.nih.gov/pubmed/21486425

Bhagirath VC, O'Malley L, Crowther MA (2011) Management of bleeding complications in the anticoagulated patient. Semin Hematol 48:285-294.
http://www.ncbi.nlm.nih.gov/pubmed/22000094

Chen D, Shrivastava S, Ma L, Tham EL, Abrahams J, Coe JD, . . . Dorling A (2011) Inhibition of Thrombin Receptor Signaling on alpha-Smooth Muscle Actin+ CD34+ Progenitors Leads to Repair After Murine Immune Vascular Injury. Arterioscler Thromb Vasc Biol.
http://www.ncbi.nlm.nih.gov/pubmed/22034512

Christensen MC, Banner C, Lefering R, Vallejo-Torres L, Morris S (2011) Quality of life after severe trauma: results from the global trauma trial with recombinant Factor VII. J Trauma 70:1524-1531.
http://www.ncbi.nlm.nih.gov/pubmed/21378585

Cocco E, Varughese J, Buza N, Bellone S, Glasgow M, Bellone M, . . . Santin AD (2011) Expression of tissue factor in adenocarcinoma and squamous cell carcinoma of the uterine cervix: implications for immunotherapy with hI-con1, a factor VII-IgGFc chimeric protein targeting tissue factor. BMC Cancer 11:263.
http://www.ncbi.nlm.nih.gov/pubmed/21693061

Davalos D, Akassoglou K (2011) Fibrinogen as a key regulator of inflammation in disease. Semin Immunopathol.
http://www.ncbi.nlm.nih.gov/pubmed/22037947

Dunne B, Xiao P, Andrews D (2011) Successful Use of Factor VIIa to Control Life-threatening Post-operative Haemorrhage in a Patient on Extra-Corporeal Membrane Oxygenation. Heart Lung Circ.
http://www.ncbi.nlm.nih.gov/pubmed/22036715

Dutton RP, Parr M, Tortella BJ, Champion HR, Bernard GR, Boffard K, . . . Hauser CJ (2011) Recombinant activated factor VII safety in trauma patients: results from the CONTROL trial. J Trauma 71:12-19.
http://www.ncbi.nlm.nih.gov/pubmed/21610529

Fischer TH, Nichols TC, Scull CM, Smith CJ, Demcheva M (2011) Poly-N-acetylglucosamine fibers amplify the effectiveness of recombinant factor VIIA on clot formation in hemophilia B canine blood. J Trauma 71:S171-175.
http://www.ncbi.nlm.nih.gov/pubmed/21814114

Gambone JE, Owens Iii AP, Mackman N (2011) Comment on "Tissue factor-dependent chemokine production aggravates experimental colitis'. Mol Med.
http://www.ncbi.nlm.nih.gov/pubmed/22027905

Gardiner C, Tannetta DS, Simms CA, Harrison P, Redman CW, Sargent IL (2011) Syncytiotrophoblast microvesicles released from pre-eclampsia placentae exhibit increased tissue factor activity. PLoS One 6:e26313.
http://www.ncbi.nlm.nih.gov/pubmed/22022598

Gessler F, Voss V, Seifert V, Gerlach R, Kogel D (2011) Knockdown of TFPI-2 promotes migration and invasion of glioma cells. Neurosci Lett 497:49-54.
http://www.ncbi.nlm.nih.gov/pubmed/21530612

Ghanny S, Warkentin TE, Crowther MA (2011) Reversing Anticoagulant Therapy. Curr Drug Discov Technol.
http://www.ncbi.nlm.nih.gov/pubmed/22023256

Huber AW, Raio L, Alberio L, Ghezzi F, Surbek DV (2011) Recombinant human factor VIIa prevents hysterectomy in severe postpartum hemorrhage: single center study. J Perinat Med.
http://www.ncbi.nlm.nih.gov/pubmed/22017328

Khorana AA (2011) Risk assessment and prophylaxis for VTE in cancer patients. J Natl Compr Canc Netw 9:789-797.
http://www.ncbi.nlm.nih.gov/pubmed/21715725

Krisl JC, Meadows HE, Greenberg CS, Mazur JE (2011) Clinical Usefulness of Recombinant Activated Factor VII in Patients with Liver Failure Undergoing Invasive Procedures. Ann Pharmacother 45:1433-1438.
http://www.ncbi.nlm.nih.gov/pubmed/22009992

Lee BJ, Kim JH, Woo SH, Kim DH, Yu YS (2011) Tissue factor is involved in retinoblastoma cell proliferation via both the Akt and extracellular signal-regulated kinase pathways. Oncol Rep 26:665-670.
http://www.ncbi.nlm.nih.gov/pubmed/21617868

Lesperance RN, Lehmann RK, Harold DM, Beekley AC, Sebesta JA, Martin MJ (2011) Recombinant Factor VIIa is Effective at Reversing Coagulopathy in a Lactic Acidosis Model. J Trauma.
http://www.ncbi.nlm.nih.gov/pubmed/22002618

Lockwood CJ (2011) Mechanisms of normal and abnormal endometrial bleeding. Menopause 18:408-411.
http://www.ncbi.nlm.nih.gov/pubmed/21499503

Mackman N, Davis GE (2011) Blood coagulation and blood vessel development: is tissue factor the missing link? Arterioscler Thromb Vasc Biol 31:2364-2366.
http://www.ncbi.nlm.nih.gov/pubmed/22011746

Mazzolai L, Bouzourene K, Hayoz D, Dignat-George F, Liu JW, Bounameaux H, . . . Kruithof EK (2011) Characterization of human late outgrowth endothelial progenitor-derived cells under various flow conditions. J Vasc Res 48:443-451.
http://www.ncbi.nlm.nih.gov/pubmed/21625177

Meadows HB, Krisl JC, Greenberg CS, Mazur JE (2011) The Use of Activated Recombinant Factor VII in a Patient with Fulminant Hepatic Failure Requiring Placement of an Intracranial Pressure Monitor. Ann Pharmacother 45:e60.
http://www.ncbi.nlm.nih.gov/pubmed/22028416

Mo X, Hao Y, Yang X, Chen S, Lu X, Gu D (2011) Association between polymorphisms in the coagulation factor VII gene and coronary heart disease risk in different ethnicities: a meta-analysis. BMC Med Genet 12:107.
http://www.ncbi.nlm.nih.gov/pubmed/21838885

Morfini M, Jimenez-Yuste V, Eichler H, Fischer R, Kirchmaier CM, Scharling B, Bjerre J (2011) Pharmacokinetic properties of two different recombinant activated factor VII formulations. Haemophilia.
http://www.ncbi.nlm.nih.gov/pubmed/21999231

Ostergaard H, Bjelke JR, Hansen L, Petersen LC, Pedersen AA, Elm T, . . . Tranholm M (2011) Prolonged half-life and preserved enzymatic properties of factor IX selectively PEGylated on native N-glycans in the activation peptide. Blood 118:2333-2341.
http://www.ncbi.nlm.nih.gov/pubmed/21700771

Puy C, Hermida J, Montes R (2011) Factor X and factor VII binding to endothelial protein C receptor differs between species. J Thromb Haemost 9:1255-1257.
http://www.ncbi.nlm.nih.gov/pubmed/21489130

Queiroz KC, Spek CA (2011) Response to Comment on "Tissue factor-dependent chemokine production aggravates experimental colitis'. Mol Med.
http://www.ncbi.nlm.nih.gov/pubmed/22027904

Rice TW, Morris S, Tortella BJ, Wheeler AP, Christensen MC (2011) Deviations from evidence based clinical management guidelines increase mortality in critically injured trauma patients. Crit Care Med.
http://www.ncbi.nlm.nih.gov/pubmed/22036858

Rochier A, Nixon A, Yamashita N, Abe R, Madri JA, Sumpio BE (2011) Laminar shear, but not orbital shear, has a synergistic effect with thrombin stimulation on tissue factor expression in human umbilical vein endothelial cells. J Vasc Surg 54:480-488.
http://www.ncbi.nlm.nih.gov/pubmed/21367569

Scola MR, Nichols TC, Zhu H, Caughey MC, Merricks EP, Raymer RA, . . . Gallippi CM (2011) ARFI Ultrasound Monitoring of Hemorrhage and Hemostasis In Vivo in Canine von Willebrand Disease and Hemophilia. Ultrasound Med Biol.
http://www.ncbi.nlm.nih.gov/pubmed/22033127

Sossdorf M, Otto GP, Claus RA, Gabriel HH, Losche W (2011) Cell-derived microparticles promote coagulation after moderate exercise. Med Sci Sports Exerc 43:1169-1176.
http://www.ncbi.nlm.nih.gov/pubmed/21131870

Stephan S, Schwarz H, Haude-Barten A, Sidelmann JJ, Fischer B, Althaus H, . . . Vitzthum F (2011) Direct chromogenic substrate immuno-capture activity assay for testing of factor VII-activating protease. Clin Chem Lab Med 49:1199-1204.
http://www.ncbi.nlm.nih.gov/pubmed/21663569

Svensson KJ, Kucharzewska P, Christianson HC, Skold S, Lofstedt T, Johansson MC, . . . Belting M (2011) Hypoxia triggers a proangiogenic pathway involving cancer cell microvesicles and PAR-2-mediated heparin-binding EGF signaling in endothelial cells. Proc Natl Acad Sci U S A 108:13147-13152.
http://www.ncbi.nlm.nih.gov/pubmed/21788507

Tiede A, Friedrich U, Stenmo C, Allen G, Giangrande P, Goudemand J, . . . Berntorp E (2011) Safety and pharmacokinetics of subcutaneously administered recombinant activated factor VII (rFVIIa). J Thromb Haemost 9:1191-1199.
http://www.ncbi.nlm.nih.gov/pubmed/21489128

Yada K, Nogami K, Ogiwara K, Shibata M, Shima M (2011) Effects of anti-factor VIII inhibitor antibodies on factor VIIa/tissue factor-catalysed activation and inactivation of factor VIII. Thromb Haemost 105:989-998.
http://www.ncbi.nlm.nih.gov/pubmed/21437361
__________________________________________________________

Vol. 17, No. 20

noreply@blogger.com (Pierre) — Mon, 17 Oct 2011 22:16:00 +0000

TRIGGER
The Twice-Monthly Electronic Newsletter on the Biology of Tissue Factor, Factor VII and TFPI
Vol. 17, No. 20 October 17, 2011

(The next issue will be on November 1, 2011)

__________________________________________________________
TRIGGER is also available by RSS Feed:

http://feeds.feedburner.com/blogspot/glro

and BLOG:
http://trigger-tf7.blogspot.com/
__________________________________________________________

PAPERS IN PRESS

None submitted for this issue.
__________________________________________________________
RECENT PUBLICATIONS ON TISSUE FACTOR, FACTOR VII, AND TFPI

THE FOLLOWING LINK WILL TAKE YOU TO THE ENTIRE LIST OF THIS ISSUE'S PUBLICATIONS IN A PUBMED "COLLECTION":
http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/1BYJPJ6cwgn62nwiHh47fhU/

Aass HC, Ovstebo R, Troseid AM, Kierulf P, Berg JP, Henriksson CE (2011) Fluorescent particles in the antibody solution result in false TF- and CD14-positive microparticles in flow cytometric analysis. Cytometry A.
http://www.ncbi.nlm.nih.gov/pubmed/21990118

Abe R, Yamashita N, Rochier A, Nixon A, Madri JA, Sumpio BE (2011) Varying effects of hemodynamic forces on tissue factor RNA expression in human endothelial cells. J Surg Res 170:150-156.
http://www.ncbi.nlm.nih.gov/pubmed/21592524

Adams MJ, Palatinus A, Harvey A, Khalafallah A (2011) Impaired control of the tissue factor pathway of blood coagulation in systemic lupus erythematosus. Lupus.
http://www.ncbi.nlm.nih.gov/pubmed/21993387

Andrie RP, Bauriedel G, Braun P, Hopp HW, Nickenig G, Skowasch D (2011) Prevalence of intimal heat shock protein 60 homologues in unstable angina and correlation with anti-heat shock protein antibody titers. Basic Res Cardiol 106:657-665.
http://www.ncbi.nlm.nih.gov/pubmed/21416407

Antoniak S, Pawlinski R, Mackman N (2011) Protease-activated receptors and myocardial infarction. IUBMB Life 63:383-389.
http://www.ncbi.nlm.nih.gov/pubmed/21438116

Augoustides JG (2011) Advances in Anticoagulation: Focus on Dabigatran, an Oral Direct Thrombin Inhibitor. J Cardiothorac Vasc Anesth.
http://www.ncbi.nlm.nih.gov/pubmed/21982327

Ben-Hadj-Khalifa-Kechiche S, Hezard N, Poitevin S, Remy MG, Florent B, Mahjoub T, Nguyen P (2010) Differential inhibitory effect of fondaparinux on the procoagulant potential of intact monocytes and monocyte-derived microparticles. J Thromb Thrombolysis 30:412-418.
http://www.ncbi.nlm.nih.gov/pubmed/20602250

Bretz N, Noske A, Keller S, Erbe-Hofmann N, Schlange T, Salnikov AV, . . . Altevogt P (2011) CD24 promotes tumor cell invasion by suppressing tissue factor pathway inhibitor-2 (TFPI-2) in a c-Src-dependent fashion. Clin Exp Metastasis.
http://www.ncbi.nlm.nih.gov/pubmed/21984372

Di Santo A, Amore C, Dell'Elba G, Manarini S, Evangelista V (2011) Glycogen synthase kinase-3 negatively regulates tissue factor expression in monocytes interacting with activated platelets. J Thromb Haemost 9:1029-1039.
http://www.ncbi.nlm.nih.gov/pubmed/21320285

Emekli-Alturfan E, Basar I, Malali E, Elemek E, Oktay S, Ayan F, . . . Noyan U (2010) Plasma tissue factor levels and salivary tissue factor activities of periodontitis patients with and without cardiovascular disease. Pathophysiol Haemost Thromb 37:77-81.
http://www.ncbi.nlm.nih.gov/pubmed/21293108

Furlan-Freguia C, Marchese P, Gruber A, Ruggeri ZM, Ruf W (2011) P2X7 receptor signaling contributes to tissue factor-dependent thrombosis in mice. J Clin Invest 121:2932-2944.
http://www.ncbi.nlm.nih.gov/pubmed/21670495

Ge C, You Y, Zou P (2010) [Preliminary study on role of endothelial cells and tissue factor in graft-versus-host disease]. Zhongguo Shi Yan Xue Ye Xue Za Zhi 18:1278-1281.
http://www.ncbi.nlm.nih.gov/pubmed/21129276

Gleeson EM, O'Donnell JS, Preston RJ (2011) The endothelial cell protein C receptor: cell surface conductor of cytoprotective coagulation factor signaling. Cell Mol Life Sci.
http://www.ncbi.nlm.nih.gov/pubmed/21968919

Guo D, Zhou H, Wu Y, Zhou F, Xu G, Wen H, Zhang X (2011) Involvement of ERK1/2/NF-kappaB signal transduction pathway in TF/FVIIa/PAR2-induced proliferation and migration of colon cancer cell SW620. Tumour Biol 32:921-930.
http://www.ncbi.nlm.nih.gov/pubmed/21625939

Harenberg J, Marx S, Kramer R, Giese C, Weiss C (2011) Determination of an international sensitivity index of thromboplastin reagents using a WHO thromboplastin as calibrator for plasma spiked with rivaroxaban. Blood Coagul Fibrinolysis.
http://www.ncbi.nlm.nih.gov/pubmed/21986465

Holmberg H, Elm T, Karpf D, Tranholm M, Bjorn SE, Stennicke H, Ezban M (2011) GlycoPEGylated rFVIIa (N7-GP) has a prolonged hemostatic effect in hemophilic mice compared with rFVIIa. J Thromb Haemost 9:1070-1072.
http://www.ncbi.nlm.nih.gov/pubmed/21366858

Jouannelle C, Giansily-Blaizot M, Monpoux F, Casagrande F, Poiree M, Berard E (2011) Spontaneous umbilical cord haematoma and congenital factor VII deficiency. Haemophilia.
http://www.ncbi.nlm.nih.gov/pubmed/21967451

Knudsen T, Olsen OH, Petersen LC (2011) Tissue factor and factor VIIa cross-species compatibility. Front Biosci 17:3196-3215.
http://www.ncbi.nlm.nih.gov/pubmed/21622229

Kurland DB, Hong C, Aarabi B, Gerzanich V, Simard JM (2011) Hemorrhagic Progression of a Contusion following Traumatic Brain Injury - a Review. J Neurotrauma.
http://www.ncbi.nlm.nih.gov/pubmed/21988198

Lopez-Vilchez I, Hedner U, Altisent C, Diaz-Ricart M, Escolar G, Galan AM (2011) Redistribution and hemostatic action of recombinant activated factor VII associated with platelets. Am J Pathol 178:2938-2948.
http://www.ncbi.nlm.nih.gov/pubmed/21641410

Matejovic M, Chvojka J, Sykora R, Krouzecky A, Radej J, Parizkova R, . . . Cerny V (2011) A 24-h work shift in intensive care personnel: biological pathways between work stress and ill health. J Int Med Res 39:629-636.
http://www.ncbi.nlm.nih.gov/pubmed/21672368

Mukherjee SD, Swystun LL, Mackman N, Wang JG, Pond G, Levine MN, Liaw PC (2010) Impact of chemotherapy on thrombin generation and on the protein C pathway in breast cancer patients. Pathophysiol Haemost Thromb 37:88-97.
http://www.ncbi.nlm.nih.gov/pubmed/21430357

Oishi K, Koyanagi S, Ohkura N (2011) Circadian mRNA expression of coagulation and fibrinolytic factors is organ-dependently disrupted in aged mice. Exp Gerontol.
http://www.ncbi.nlm.nih.gov/pubmed/21963655

Opstad TB, Pettersen AA, Bratseth V, Arnesen H, Seljeflot I (2010) The influence of tissue factor and tissue factor pathway inhibitor polymorphisms on thrombin generation in stable coronary artery disease. Pathophysiol Haemost Thromb 37:98-103.
http://www.ncbi.nlm.nih.gov/pubmed/21555871

Persson E, Olsen OH (2011) Allosteric activation of coagulation factor VIIa. Front Biosci 17:3156-3163.
http://www.ncbi.nlm.nih.gov/pubmed/21622226

Rancourt RC, Veress LA, Guo X, Jones TN, Hendry-Hofer TB, White CW (2011) Airway Tissue Factor-Dependent Coagulation Activity in Response to Sulfur Mustard Analog 2-chloroethyl ethyl sulfide (CEES). Am J Physiol Lung Cell Mol Physiol.
http://www.ncbi.nlm.nih.gov/pubmed/21964405

Schlunk F, Van Cott EM, Hayakawa K, Pfeilschifter W, Lo EH, Foerch C (2011) Recombinant Activated Coagulation Factor VII and Prothrombin Complex Concentrates Are Equally Effective in Reducing Hematoma Volume in Experimental Warfarin-Associated Intracerebral Hemorrhage. Stroke.
http://www.ncbi.nlm.nih.gov/pubmed/21998055

Semeraro F, Ammollo CT, Morrissey JH, Dale GL, Friese P, Esmon NL, Esmon CT (2011) Extracellular histones promote thrombin generation through platelet-dependent mechanisms: involvement of platelet TLR2 and TLR4. Blood 118:1952-1961.
http://www.ncbi.nlm.nih.gov/pubmed/21673343

Simioni P, Spiezia L (2011) Factor VIIa-AT complex plasma levels and arterial thrombosis. Thromb Res.
http://www.ncbi.nlm.nih.gov/pubmed/21995975

Song Z, Jin R, Yu S, Nanda A, Granger DN, Li G (2011) Crucial Role of CD40 Signaling in Vascular Wall Cells in Neointimal Formation and Vascular Remodeling After Vascular Interventions. Arterioscler Thromb Vasc Biol.
http://www.ncbi.nlm.nih.gov/pubmed/21998133

Srinivasan R, Bogdanov VY (2011) Alternatively spliced tissue factor: discovery, insights, clinical implications. Front Biosci 17:3061-3071.
http://www.ncbi.nlm.nih.gov/pubmed/21622222

Tchaikovski SN, Thomassen MC, Costa S, Peeters LL, Rosing J (2011) Role of protein S and tissue factor pathway inhibitor in the development of activated protein C resistance early in pregnancy in women with a history of preeclampsia. Thromb Haemost 106.
http://www.ncbi.nlm.nih.gov/pubmed/21979881

Tokgoz H, Caliskan U, Lavigne-Lissalde G, Giansily-Blaizot M (2011) Successful prophylactic use of recombinant activated factor VII (rFVIIa) in a patient with congenital FVII deficiency and inhibitors to FVII. Haemophilia.
http://www.ncbi.nlm.nih.gov/pubmed/21973016

Vincent JL, Dutton R, Parr M, Hauser C (2011) Massive bleeding in polytrauma: how can we make progress? Crit Care 15:196.
http://www.ncbi.nlm.nih.gov/pubmed/21996523

Wertz D, Boveroux P, Peters P, Lenelle J, Franssen C (2011) Surgical resection of a sphenoid wing meningioma in a patient with Glanzmann thrombasthenia. Acta Anaesthesiol Belg 62:83-86.
http://www.ncbi.nlm.nih.gov/pubmed/21919374

Wu D, Xiong L, Wu S, Jiang M, Lian G, Wang M (2011) TFPI-2 methylation predicts poor prognosis in non-small cell lung cancer. Lung Cancer.
http://www.ncbi.nlm.nih.gov/pubmed/21983100

Yamamoto E, Kitano Y, Hasumi K (2011) Elucidation of Crucial Structures for a Catechol-Based Inhibitor of Plasma Hyaluronan-Binding Protein (Factor VII Activating Protease) Autoactivation. Biosci Biotechnol Biochem.
http://www.ncbi.nlm.nih.gov/pubmed/21979097

Zhou W, Schwarting S, Illanes S, Liesz A, Middelhoff M, Zorn M, . . . Veltkamp R (2011) Hemostatic Therapy in Experimental Intracerebral Hemorrhage Associated With the Direct Thrombin Inhibitor Dabigatran. Stroke.
http://www.ncbi.nlm.nih.gov/pubmed/21998060
__________________________________________________________

Vol. 17, No. 19

noreply@blogger.com (Pierre) — Mon, 03 Oct 2011 20:17:00 +0000

TRIGGER
The Twice-Monthly Electronic Newsletter on the Biology of Tissue Factor, Factor VII and TFPI
Vol. 17, No. 19 October 3, 2011

(The next issue will be on October 17, 2011)

__________________________________________________________
TRIGGER is also available by RSS Feed:

http://feeds.feedburner.com/blogspot/glro

and BLOG:
http://trigger-tf7.blogspot.com/
__________________________________________________________

PAPERS IN PRESS

None submitted for this issue.
__________________________________________________________
POSITIONS SOUGHT/AVAILABLE
Haematologic Technologies, Inc. in Essex Junction, VT is looking for laboratory technicians and PhD scientists to help us grow. Experience in protein chemistry and protein purification required. Please see our job posting on our website here:
http://www.haemtech.com/news.htm
__________________________________________________________
UPCOMING SCIENTIFIC MEETINGS

53rd ASH Annual Meeting. San Diego, CA, USA, December 10-13, 2011 (abstract deadline is past): http://www.hematology.org/Meetings/Annual-Meeting/

ATVB 2012 Scientific Sessions. Hilton Chicago, Chicago Illinois, April 18-20, 2012. Abstract deadline is January 5, 2012: http://my.americanheart.org/professional/Sessions/ATVB/ATVB_UCM_316902_SubHomePage.jsp

6th Symposium on Hemostasis: Special Focus on Tissue Factor, Factor VIIa and Tissue Factor Pathway Inhibitor. Carolina Inn, Chapel Hill, NC, May 3-5, 2012: http://www.med.unc.edu/www/events/6th-symposium-on-hemostasis

2012 Hemostasis Gordon Conference. Waterville Valley Resort, Waterville Valley, NH, July 22-27, 2012. Abstracts can be submitted for poster presentations: http://www.grc.org/programs.aspx?year=2012&program=hemostasis

http://www.grc.org/programs.aspx?year=2012&program=grs_hemo

__________________________________________________________
RECENT PUBLICATIONS ON TISSUE FACTOR, FACTOR VII, AND TFPI

THE FOLLOWING LINK WILL TAKE YOU TO THE ENTIRE LIST OF THIS ISSUE'S PUBLICATIONS IN A PUBMED "COLLECTION":
http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/1rExffZPU21QbyzIotgKoxH/

(2007) Utilization and Clinical Data on In-Hospital, Off-Label Uses of Recombinant Factor VIIa.
http://www.ncbi.nlm.nih.gov/pubmed/21938824

Abdel-Bakky MS, Hammad MA, Walker LA, Ashfaq MK (2011) Silencing of tissue factor by antisense deoxyoligonucleotide prevents monocrotaline/LPS renal injury in mice. Arch Toxicol 85:1245-1256.
http://www.ncbi.nlm.nih.gov/pubmed/21327618

Abel R, Salam NK, Shelley J, Farid R, Friesner RA, Sherman W (2011) Contribution of explicit solvent effects to the binding affinity of small-molecule inhibitors in blood coagulation factor serine proteases. ChemMedChem 6:1049-1066.
http://www.ncbi.nlm.nih.gov/pubmed/21506273

Agar C, de Groot PG, Marquart JA, Meijers JC (2011) Evolutionary conservation of the lipopolysaccharide binding site of beta2-glycoprotein I. Thromb Haemost 106.
http://www.ncbi.nlm.nih.gov/pubmed/21947351

Ando K, Ishibashi T, Ohkawara H, Inoue N, Sugimoto K, Uekita H, . . . Takeishi Y (2011) Crucial Role of Membrane Type 1 Matrix Metalloproteinase (MT1- MMP) in RhoA/Rac1-Dependent Signaling Pathways in Thrombin- Stimulated Endothelial Cells. J Atheroscler Thromb 18:762-773.
http://www.ncbi.nlm.nih.gov/pubmed/21628952

Blank M, Baraam L, Eisenstein M, Fridkin M, Dardik R, Heldman Y, . . . Shoenfeld Y (2011) beta2-Glycoprotein-I based peptide regulate endothelial-cells tissue-factor expression via negative regulation of pGSK3beta expression and reduces experimental-antiphospholipid-syndrome. J Autoimmun 37:8-17.
http://www.ncbi.nlm.nih.gov/pubmed/21524885

Butros L, Boayue K, Mathew P (2011) Current difficulties and recent advances in bypass therapy for the management of hemophilia with inhibitors: a new and practical formulation of recombinant factor VIIa. Drug Des Devel Ther 5:275-282.
http://www.ncbi.nlm.nih.gov/pubmed/21625417

Campello E, Spiezia L, Radu CM, Bulato C, Castelli M, Gavasso S, Simioni P (2011) Endothelial, platelet, and tissue factor-bearing microparticles in cancer patients with and without venous thromboembolism. Thromb Res 127:473-477.
http://www.ncbi.nlm.nih.gov/pubmed/21256535

Carlsson K, Persson E, Lindgren M, Carlsson U, Svensson M (2011) Effects on the conformation of FVIIa by sTF and Ca(2+) binding: Studies of fluorescence resonance energy transfer and quenching. Biochem Biophys Res Commun.
http://www.ncbi.nlm.nih.gov/pubmed/21924243

Cheng J, Xu J, Duanmu J, Zhou H, Booth CJ, Hu Z (2011) Effective Treatment of Human Lung Cancer by Targeting Tissue Factor with a Factor VII-Targeted Photodynamic Therapy. Curr Cancer Drug Targets.
http://www.ncbi.nlm.nih.gov/pubmed/21933104

Chu AJ (2011) Tissue factor, blood coagulation, and beyond: an overview. Int J Inflam 2011:367284.
http://www.ncbi.nlm.nih.gov/pubmed/21941675

De Rop C, Stadler M, Buchholz S, Eisert R, Ganser A, Trummer A (2011) Evaluation of tissue factor bearing microparticles as biomarkers in allogeneic stem-cell transplantation. Transplantation 92:351-358.
http://www.ncbi.nlm.nih.gov/pubmed/21681142

Di Nisio M, Baudo F, Cosmi B, D'Angelo A, De Gasperi A, Malato A, . . . Squizzato A (2011) Diagnosis and treatment of disseminated intravascular coagulation: Guidelines of the Italian Society for Haemostasis and Thrombosis (SISET). Thromb Res.
http://www.ncbi.nlm.nih.gov/pubmed/21930293

Dieterich M, Mann E, Wagner KF, Kramer-Steiner B, Reimer T, Gerber B, Stubert J (2011) Desmopressin-induced Moschcowitz-like syndrome after treatment of uterine atonic bleeding in a 28-year-old pregnant woman: case report and overview of the literature. Blood Coagul Fibrinolysis.
http://www.ncbi.nlm.nih.gov/pubmed/21921792

Ding L, Ma W, Littmann T, Camp R, Shen J (2011) The P2Y(2) nucleotide receptor mediates tissue factor expression in human coronary artery endothelial cells. J Biol Chem 286:27027-27038.
http://www.ncbi.nlm.nih.gov/pubmed/21652710

Disse J, Ruf W (2011) The endothelial protein C receptor is required for tissue factor ternary complex signaling in the mouse. J Thromb Haemost.
http://www.ncbi.nlm.nih.gov/pubmed/21951329

Eisenreich A, Boltzen U, Malz R, Schultheiss HP, Rauch U (2011) Overexpression of alternatively spliced tissue factor induces the pro-angiogenic properties of murine cardiomyocytic HL-1 cells. Circ J 75:1235-1242.
http://www.ncbi.nlm.nih.gov/pubmed/21389637

Ettelaie C, Fountain D, Collier ME, Elkeeb AM, Xiao YP, Maraveyas A (2011) Low molecular weight heparin downregulates tissue factor expression and activity by modulating growth factor receptor-mediated induction of nuclear factor-kappaB. Biochim Biophys Acta.
http://www.ncbi.nlm.nih.gov/pubmed/21946214

Fang WQ, Zhang Q, Peng YB, Chen M, Lin XP, Wu JH, . . . Jin H (2011) Resistin level is positively correlated with thrombotic complications in Southern Chinese metabolic syndrome patients. J Endocrinol Invest 34:e36-42.
http://www.ncbi.nlm.nih.gov/pubmed/20671416

Gerotziafas GT, Galea V, Mbemba E, Kartechi A, Sassi M, Baccouche H, . . . Elalamy I (2011) Tissue factor over-expression by human pancreatic cancer cells BXPC3 is related to higher prothrombotic potential as compared to breast cancer cells MCF7. Thromb Res.
http://www.ncbi.nlm.nih.gov/pubmed/21917301

Henriquez S, Calderon C, Quezada M, Oliva B, Bravo ML, Aranda E, . . . Owen GI (2011) Progesterone utilizes distinct membrane pools of tissue factor to increase coagulation and invasion and these effects are inhibited by TFPI. J Cell Physiol.
http://www.ncbi.nlm.nih.gov/pubmed/21344386

Herrera RN, de Amaya EI, Aguilar RC, Turoni CJ, Maranon R, Berman SG, . . . de Bruno MP (2011) Inflammatory and prothrombotic activation with conserved endothelial function in patients with chronic, asymptomatic chagas disease. Clin Appl Thromb Hemost 17:502-507.
http://www.ncbi.nlm.nih.gov/pubmed/20699256

Holmberg H, Kiersgaard MK, Mikkelsen LF, Tranholm M (2011) Impact of blood sampling technique on blood quality and animal welfare in haemophilic mice. Lab Anim 45:114-120.
http://www.ncbi.nlm.nih.gov/pubmed/21382833

Holy EW, Forestier M, Richter EK, Akhmedov A, Leiber F, Camici GG, . . . Tanner FC (2011) Dietary alpha-linolenic acid inhibits arterial thrombus formation, tissue factor expression, and platelet activation. Arterioscler Thromb Vasc Biol 31:1772-1780.
http://www.ncbi.nlm.nih.gov/pubmed/21571683

Hvas AM, Boas TW, Jensen M, Lindskov C, Folkersen L, Ravn HB (2011) Change in Hemostatic Intervention After Implementation of Thromboelastometry. J Cardiothorac Vasc Anesth.
http://www.ncbi.nlm.nih.gov/pubmed/21924638

Ignjatovic V, Than J, Summerhayes R, Newall F, Horton S, Cochrane A, Monagle P (2011) Hemostatic response in paediatric patients undergoing cardiopulmonary bypass surgery. Pediatr Cardiol 32:621-627.
http://www.ncbi.nlm.nih.gov/pubmed/21360266

Jurk K, Lahav J, Van Aken H, Brodde MF, Nofer JR, Kehrel BE (2011) Extracellular Protein Disulfide Isomerase Regulates Feedback Activation of Platelet Thrombin Generation Via Modulation of Coagulation Factor Binding. J Thromb Haemost.
http://www.ncbi.nlm.nih.gov/pubmed/21929690

Kacka K, Kacki W, Merak J, Bleka A (2010) Use of recombinant activated factor VII for reduction of perioperative blood loss during elective surgical correction of spine deformity in a Jehovah's Witness. Case report. Ortop Traumatol Rehabil 12:448-458.
http://www.ncbi.nlm.nih.gov/pubmed/21057153

Karkouti K, Levy JH (2011) Commentary: Recombinant Activated Factor VII: The Controversial Conundrum Regarding Its Off-Label Use. Anesth Analg 113:711-712.
http://www.ncbi.nlm.nih.gov/pubmed/21788315

Kassel KM, Owens III AP, Rockwell CE, Sullivan BP, Wang R, Tawfik O, . . . Luyendyk JP (2011) Protease-Activated Receptor 1 and Hematopoietic Cell Tissue Factor Are Required for Hepatic Steatosis in Mice Fed a High-Fat Diet. Am J Pathol.
http://www.ncbi.nlm.nih.gov/pubmed/21907177

Lee CN, Heidbrink JL, McKinnon K, Bushman V, Olsen H, Fitzhugh W, . . . Moore PA (2011) RNA Interference Characterization of Proteins Discovered by Proteomic Analysis of Pancreatic Cancer Reveals Function in Cell Growth and Survival. Pancreas.
http://www.ncbi.nlm.nih.gov/pubmed/21934552

Lhermusier T, Van Rottem J, Garcia C, Xuereb JM, Ragab A, Martin V, . . . Payrastre B (2011) The Syk-kinase inhibitor R406 impairs platelet activation and monocyte tissue factor expression triggered by heparin-PF4 complex directed antibodies. J Thromb Haemost 9:2067-2076.
http://www.ncbi.nlm.nih.gov/pubmed/21848694

Liang HP, Brophy TM, Hogg PJ (2011) Redox properties of the tissue factor Cys186-Cys209 disulfide bond. Biochem J 437:455-460.
http://www.ncbi.nlm.nih.gov/pubmed/21595632

Lima LG, Oliveira AS, Campos LC, Bonamino M, Chammas R, Werneck C, . . . Monteiro RQ (2011) Malignant transformation in melanocytes is associated with increased production of procoagulant microvesicles. Thromb Haemost 106:712-723.
http://www.ncbi.nlm.nih.gov/pubmed/21800005

Lisman T, Porte RJ (2011) Recombinant factor VIIa to treat severe bleeding in patients with liver disease: Pitfalls and possibilities. J Hepatol 55:950-951.
http://www.ncbi.nlm.nih.gov/pubmed/21925325

Luo D, Szaba FM, Kummer LW, Plow EF, Mackman N, Gailani D, Smiley ST (2011) Protective roles for fibrin, tissue factor, plasminogen activator inhibitor-1, and thrombin activatable fibrinolysis inhibitor, but not factor XI, during defense against the gram-negative bacterium Yersinia enterocolitica. J Immunol 187:1866-1876.
http://www.ncbi.nlm.nih.gov/pubmed/21724997

Luporsi P, Chopard R, Janin S, Racadot E, Bernard Y, Ecarnot F, . . . Schiele F (2011) Use of recombinant factor VIIa (NovoSeven((R))) in 8 patients with ongoing life-threatening bleeding treated with fondaparinux. Acute Card Care 13:93-98.
http://www.ncbi.nlm.nih.gov/pubmed/21517672

Ma Z, Zhang T, Wang R, Cheng Z, Xu H, Li W, . . . Wang X (2011) Tissue factor-factor VIIa complex induces epithelial ovarian cancer cell invasion and metastasis through a monocytes-dependent mechanism. Int J Gynecol Cancer 21:616-624.
http://www.ncbi.nlm.nih.gov/pubmed/21543928

Marchetti M, Russo L, Balducci D, Falanga A (2011) All trans-retinoic acid modulates the procoagulant activity of human breast cancer cells. Thromb Res 128:368-374.
http://www.ncbi.nlm.nih.gov/pubmed/21458031

Martinez-Sales V, Vila V, Mico L, Contreras MT, Escandell A, Reganon E (2011) [Circulating endothelial cells and microparticles in patients with antiphospholipid antibodies]. Med Clin (Barc) 136:431-433.
http://www.ncbi.nlm.nih.gov/pubmed/21051055

Mast AE (2011) Alternatively spliced tissue factor pathway inhibitor: functional implications. Front Biosci (Schol Ed) 3:1457-1462.
http://www.ncbi.nlm.nih.gov/pubmed/21622281

Mazer CD, Leong-Poi H, Chhina T, Alfardan Z, Lapierre H, Wang Z, . . . Teitel J (2011) Recombinant factor VIIa affects anastomotic patency of vascular grafts in a rabbit model. J Thorac Cardiovasc Surg 142:418-423.
http://www.ncbi.nlm.nih.gov/pubmed/21281943

Meziani F, Delabranche X, Asfar P, Toti F (2010) Bench-to-bedside review: circulating microparticles--a new player in sepsis? Crit Care 14:236.
http://www.ncbi.nlm.nih.gov/pubmed/21067540

Mitrophanov AY, Reifman J (2011) Kinetic modeling sheds light on the mode of action of recombinant factor VIIa on thrombin generation. Thromb Res 128:381-390.
http://www.ncbi.nlm.nih.gov/pubmed/21641634

Morse BC, Dente CJ, Hodgman EI, Shaz BH, Nicholas JM, Wyrzykowski AD, . . . Feliciano DV (2011) The Effects of Protocolized Use of Recombinant Factor VIIa Within a Massive Transfusion Protocol in a Civilian Level I Trauma Center. Am Surg 77:1043-1049.
http://www.ncbi.nlm.nih.gov/pubmed/21944521

Nadir Y, Kenig Y, Drugan A, Shafat I, Brenner B (2011) An assay to evaluate heparanase procoagulant activity. Thromb Res 128:e3-e8.
http://www.ncbi.nlm.nih.gov/pubmed/21481923

Natorska J, Wypasek E, Grudzien G, Sobczyk D, Marek G, Filip G, . . . Undas A (2011) Does Diabetes Accelerate the Progression of Aortic Stenosis through Enhanced Inflammatory Response within Aortic valves? Inflammation.
http://www.ncbi.nlm.nih.gov/pubmed/21935671

Naumnik B, Rydzewska-Rosolowska A, Mysliwiec M (2011) Different Effects of Enoxaparin, Nadroparin, and Dalteparin on Plasma TFPI During Hemodialysis: A Prospective Crossover Randomized Study. Clin Appl Thromb Hemost 17:480-486.
http://www.ncbi.nlm.nih.gov/pubmed/20682597

Oehmcke S, Morgelin M, Malmstrom J, Linder A, Chew M, Thorlacius H, Herwald H (2011) Stimulation of blood mononuclear cells with bacterial virulence factors leads to the release of pro-coagulant and pro-inflammatory microparticles. Cell Microbiol.
http://www.ncbi.nlm.nih.gov/pubmed/21951918

Ogiwara K, Nogami K, Shima M (2011) Factor VIII activation by factor VIIa analog (V158D/E296V/M298Q) in tissue factor-independent mechanisms. Thromb Haemost 106:665-674.
http://www.ncbi.nlm.nih.gov/pubmed/21901232

Perez-Ferrer A, Gredilla E, de Vicente J, Laporta Y (2011) Cardiac Surgery Without Blood Products in a Jehovah's Witness Child With Factor VII Deficiency. J Cardiothorac Vasc Anesth.
http://www.ncbi.nlm.nih.gov/pubmed/21924639

Pinazo MJ, Tassies D, Munoz J, Fisa R, de Jesus Posada E, Monteagudo J, . . . Gascon J (2011) Hypercoagulability biomarkers in Trypanosoma cruzi -infected patients. Thromb Haemost 106:617-623.
http://www.ncbi.nlm.nih.gov/pubmed/21866301

Raffa S, Reverter JC, Seijo S, Tassies D, Abraldes JG, Bosch J, Garcia-Pagan JC (2011) Hypercoagulability in Patients with Chronic Non-Cirrhotic Portal Vein Thrombosis. Clin Gastroenterol Hepatol.
http://www.ncbi.nlm.nih.gov/pubmed/21946303

Sakai T, Inoue S, Takei M, Ogawa G, Hamazaki Y, Ota H, Koboyashi Y (2011) Activated inflammatory cells participate in thrombus size through tissue factor and plasminogen activator inhibitor-1 in acute coronary syndrome: Immunohistochemical analysis. Thromb Res 127:443-449.
http://www.ncbi.nlm.nih.gov/pubmed/21388659

Schmid D, Svoboda M, Sorgner A, Moravcevic I, Thalhammer T, Chiba P, Moslinger T (2011) Glibenclamide reduces proinflammatory cytokines in an ex vivo model of human endotoxinaemia under hypoxaemic conditions. Life Sci.
http://www.ncbi.nlm.nih.gov/pubmed/21925514

Silveira A, Scanavini D, Boquist S, Ericsson CG, Hellenius ML, Leander K, . . . Hamsten A (2011) Relationships of plasma factor VIIa-antithrombin complexes to manifest and future cardiovascular disease. Thromb Res.
http://www.ncbi.nlm.nih.gov/pubmed/21925715

Skolnick BE, Shenouda M, Khutoryansky NM, Pusateri AE, Gabriel D, Carr ME (2011) Reversal of Clopidogrel-Induced Bleeding with rFVIIa in Healthy Subjects: A Randomized, Placebo-Controlled, Double-Blind, Exploratory Study. Anesth Analg 113:703-710.
http://www.ncbi.nlm.nih.gov/pubmed/21890888

Srinivasan R, Ozhegov E, Van den Berg YW, Aronow BJ, Franco RS, Palascak MB, . . . Bogdanov VY (2011) Splice variants of tissue factor promote monocyte-endothelial interactions by triggering the expression of cell adhesion molecules via integrin-mediated signaling. J Thromb Haemost 9:2087-2096.
http://www.ncbi.nlm.nih.gov/pubmed/21812913

Szmurlo D, Derylo L, Rys P, Wladysiuk M (2011) [Health economics of inhibitor bypassing agents in haemophilia A-activated prothrombin complex concentrate (aPCC) and recombinant activated factor VIIa (rFVIIa)]. Pol Merkur Lekarski 30:202-207.
http://www.ncbi.nlm.nih.gov/pubmed/21544998

Takeuchi H, Fernandez-Valdivia RC, Caswell DS, Nita-Lazar A, Rana NA, Garner TP, . . . Haltiwanger RS (2011) Rumi functions as both a protein O-glucosyltransferase and a protein O-xylosyltransferase. Proc Natl Acad Sci U S A.
http://www.ncbi.nlm.nih.gov/pubmed/21949356

Taniguchi M, Ono N, Hayashi A, Yakura Y, Takeya H (2011) Effect of dibutyryl cyclic adenosine monophosphate on the gene expression of plasminogen activator inhibitor-1 and tissue factor in adipocytes. Thromb Res 128:375-380.
http://www.ncbi.nlm.nih.gov/pubmed/21496886

Teruel R, Perez-Sanchez C, Corral J, Herranz MT, Perez-Andreu V, Saiz E, . . . Martinez C (2011) Identification of miRNAs as potential modulators of tissue factor expression in patients with systemic lupus erythematosus and antiphospholipid syndrome. J Thromb Haemost 9:1985-1992.
http://www.ncbi.nlm.nih.gov/pubmed/21794077

Tetik S, Ak K, Sahin Y, Gulsoy O, Isbir S, Arsan S, Yardimci T (2011) Postoperative statin therapy attenuates the intensity of systemic inflammation and increases fibrinolysis after coronary artery bypass grafting. Clin Appl Thromb Hemost 17:526-531.
http://www.ncbi.nlm.nih.gov/pubmed/20805103

Tse EY, Cheung WY, Ng KF, Luk KD (2011) Reducing perioperative blood loss and allogeneic blood transfusion in patients undergoing major spine surgery. J Bone Joint Surg Am 93:1268-1277.
http://www.ncbi.nlm.nih.gov/pubmed/21776581

Undas A, Jankowski M, Kaczmarek P, Sladek K, Brummel-Ziedins K (2011) Thrombin generation in chronic obstructive pulmonary disease: Dependence on plasma factor composition. Thromb Res 128:e24-28.
http://www.ncbi.nlm.nih.gov/pubmed/21624643

van den Hengel LG, Kocaturk B, Reitsma PH, Ruf W, Versteeg HH (2011) Complete abolishment of coagulant activity in monomeric disulfide-deficient tissue factor. Blood 118:3446-3448.
http://www.ncbi.nlm.nih.gov/pubmed/21940832

van den Hengel LG, Versteeg HH (2011) Tissue factor signaling: a multi-faceted function in biological processes. Front Biosci (Schol Ed) 3:1500-1510.
http://www.ncbi.nlm.nih.gov/pubmed/21622285

Wertz D, Boveroux P, Peters P, Lenelle J, Franssen C (2011) Surgical resection of a sphenoid wing meningioma in a patient with Glanzmann thrombasthenia. Acta Anaesthesiol Belg 62:83-86.
http://www.ncbi.nlm.nih.gov/pubmed/21919374

Xu C, Deng F, Mao Z, Zhang J, Wang H, Wang J, . . . Ma D (2011) The interaction of the second Kunitz-type domain (KD2) of TFPI-2 with a novel interaction partner, prosaposin, mediates the inhibition of the invasion and migration of human fibrosarcoma cells. Biochem J.
http://www.ncbi.nlm.nih.gov/pubmed/21943334

Xu C, Gui Q, Chen W, Wu L, Sun W, Zhang N, . . . Fu X (2011) Small interference RNA targeting tissue factor inhibits human lung adenocarcinoma growth in vitro and in vivo. J Exp Clin Cancer Res 30:63.
http://www.ncbi.nlm.nih.gov/pubmed/21619686

Yates KR, Welsh J, Echrish HH, Greenman J, Maraveyas A, Madden LA (2011) Pancreatic cancer cell and microparticle procoagulant surface characterization: involvement of membrane-expressed tissue factor, phosphatidylserine and phosphatidylethanolamine. Blood Coagul Fibrinolysis.
http://www.ncbi.nlm.nih.gov/pubmed/21941170

Zheng XW, Kudaravalli R, Russell TT, Dimichele DM, Gibb C, Russell JE, . . . Pollak ES (2011) Mutation in the factor VII hepatocyte nuclear factor 4alpha-binding site contributes to factor VII deficiency. Blood Coagul Fibrinolysis 22:624-627.
http://www.ncbi.nlm.nih.gov/pubmed/21760481
__________________________________________________________

Vol. 17, No. 18

noreply@blogger.com (Pierre) — Thu, 15 Sep 2011 18:24:00 +0000

TRIGGER
The Twice-Monthly Electronic Newsletter on the Biology of Tissue Factor, Factor VII and TFPI
Vol. 17, No. 18 September 15, 2011

(The next issue will be on October 3, 2011)

__________________________________________________________
TRIGGER is also available by RSS Feed:

http://feeds.feedburner.com/blogspot/glro

and BLOG:
http://trigger-tf7.blogspot.com/
__________________________________________________________

PRODUCT ANNOUNCEMENT

Haematologic Technologies, Inc. supplies a full range of purified proteins and antibodies for use in thrombosis research. These proteins include:

Purified human factor VIIa - purified from human plasma, and greater than 95% pure by SDS-PAGE. Anti-VIIa is also available. http://www.haemtech.com/Enzymes/Factor_VIIa.htm

Recombinant human Tissue Factor - Fully functional, purified recombinant (Baculovirus) full -length Tissue factor. Anti-TF is also available. http://www.haemtech.com/Other/TissueFactor.htm

Corn Trypsin Inhibitor - for use in thrombin generation assays and for the study of TF-dependent pathway of coagulation. http://www.haemtech.com/Inhibitors_Substrates/CTI.htm

Contact customer service (hti AT haemtech DOT com) for additional information or simply visit our website via the links above. Please include "Trigger" in the subject line.

DISCLAIMER: Commercial product announcements appearing in TRIGGER are provided "as is" for informational purposes only. The editors of TRIGGER have not necessarily evaluated any materials from commercial suppliers described in this newsletter or on its web sites, and we certainly are not endorsing any specific suppliers or products. Furthermore, the editors receive no revenues from any source in the course of publishing TRIGGER.
__________________________________________________________
PAPERS IN PRESS
None submitted for this issue.
__________________________________________________________
RECENT PUBLICATIONS ON TISSUE FACTOR, FACTOR VII, AND TFPI

THE FOLLOWING LINK WILL TAKE YOU TO THE ENTIRE LIST OF THIS ISSUE'S PUBLICATIONS IN A PUBMED "COLLECTION":
http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/1pWlfra1u7gGhm5MJnG6GUl/

Abdel-Bakky MS, Hammad MA, Walker LA, Ashfaq MK (2011) Tissue factor dependent liver injury causes release of retinoid receptors (RXR-alpha and RAR-alpha) as lipid droplets. Biochem Biophys Res Commun 410:146-151.
http://www.ncbi.nlm.nih.gov/pubmed/21658367

Agar C, de Groot PG, Morgelin M, Monk SD, van Os G, Levels JH, . . . Meijers JC (2011) beta-glycoprotein I: a novel component of innate immunity. Blood 117:6939-6947.
http://www.ncbi.nlm.nih.gov/pubmed/21454452

Aleman MM, Gardiner C, Harrison P, Wolberg AS (2011) Differential Contributions of Monocyte- and Platelet-derived Microparticles towards Thrombin Generation and Fibrin Formation and Stability. J Thromb Haemost.
http://www.ncbi.nlm.nih.gov/pubmed/21883880

Bastarache JA, Sebag SC, Grove BS, Ware LB (2011) Interferon-gamma and tumor necrosis factor-alpha act synergistically to up-regulate tissue factor in alveolar epithelial cells. Exp Lung Res 37:509-517.
http://www.ncbi.nlm.nih.gov/pubmed/21913843

Blatny J, Seidlova D, Penka M, Ovesna P, Brabec P, Sevcik P, . . . Cerny V (2011) Severe postpartum haemorrhage treated with recombinant activated Factor VII in 80 Czech patients: analysis of the UniSeven registry. Int J Obstet Anesth.
http://www.ncbi.nlm.nih.gov/pubmed/21907559

Chen Z, Huo JR, Yang L, Zhu HY (2011) Effect of ligustrazine on mice model of hepatic veno-occlusive disease induced by Gynura segetum. J Gastroenterol Hepatol 26:1016-1021.
http://www.ncbi.nlm.nih.gov/pubmed/21251065

Cimmino G, D'Amico C, Vaccaro V, D'Anna M, Golino P (2011) The missing link between atherosclerosis, inflammation and thrombosis: is it tissue factor? Expert Rev Cardiovasc Ther 9:517-523.
http://www.ncbi.nlm.nih.gov/pubmed/21517734

Colace TV, Jobson J, Diamond SL (2011) Relipidated Tissue Factor Linked to Collagen Surfaces Potentiates Platelet Adhesion and Fibrin Formation in a Microfluidic Model of Vessel Injury. Bioconjug Chem.
http://www.ncbi.nlm.nih.gov/pubmed/21902184

Delluc A, Rousseau A, Delluc C, Le Moigne E, Le Gal G, Mottier D, . . . Lacut K (2011) Venous thromboembolism in patients with pancreatic cancer: implications of circulating tissue factor. Blood Coagul Fibrinolysis 22:295-300.
http://www.ncbi.nlm.nih.gov/pubmed/21372691

Egorina EM, Sovershaev MA, Bogdanov VY, Sovershaev TA, Fallon JT, Seredkina N, . . . Hansen JB (2011) Low thrombogenicity of calcified atherosclerotic plaques is associated with bone morphogenetic protein-2-dependent inhibition of tissue factor expression. Blood Coagul Fibrinolysis.
http://www.ncbi.nlm.nih.gov/pubmed/21897206

Ganetsky M, Babu KM, Salhanick SD, Brown RS, Boyer EW (2011) Dabigatran: Review of Pharmacology and Management of Bleeding Complications of This Novel Oral Anticoagulant. J Med Toxicol.
http://www.ncbi.nlm.nih.gov/pubmed/21887485

Girolami A, Bertozzi I, de Marinis GB, Bonamigo E, Fabris F (2011) Activated FVII levels in factor VII Padua (Arg304Gln) coagulation disorder and in true factor VII deficiency: a study in homozygotes and heterozygotes. Hematology 16:308-312.
http://www.ncbi.nlm.nih.gov/pubmed/21902896

Gringeri A, Fischer K, Karafoulidou A, Klamroth R, Lopez-Fernandez MF, Mancuso E (2011) Sequential combined bypassing therapy is safe and effective in the treatment of unresponsive bleeding in adults and children with haemophilia and inhibitors. Haemophilia 17:630-635.
http://www.ncbi.nlm.nih.gov/pubmed/21323801

Han CS, Schatz F, Lockwood CJ (2011) Abruption-associated prematurity. Clin Perinatol 38:407-421.
http://www.ncbi.nlm.nih.gov/pubmed/21890016

Hayanga AJ (2011) Off-Label Use of Recombinant Factor VIIa. Ann Intern Med 155:337-338.
http://www.ncbi.nlm.nih.gov/pubmed/21893632

Hong-Xia W, Xiu-Mei L, Xiu-Hua H, Ya-Jun J, Gui-Hua Z, Wan-Chuan Z (2011) Clinical Significance of Tissue Factor and Vascular Endothelial Growth Factor Expressions on CD14+ Monocytes in Patients with Non Hodgkin Lymphoma. Zhongguo Yi Xue Ke Xue Yuan Xue Bao 33:427-431.
http://www.ncbi.nlm.nih.gov/pubmed/21906453

Huang XX, Pang BS, Yang YH, Zhang HY, Guo SL (2011) [Change of coagulation functions and its significance in acute exacerbation of chronic obstructive pulmonary disease]. Zhonghua Yi Xue Za Zhi 91:1543-1545.
http://www.ncbi.nlm.nih.gov/pubmed/21914367

Ingerslev J, Sorensen B (2011) Parallel use of by-passing agents in haemophilia with inhibitors: a critical review. Br J Haematol.
http://www.ncbi.nlm.nih.gov/pubmed/21895627

Jenabali Jahromi B, Karimi M (2011) Long-term follow-up of prophylaxis with recombinant activated factor VII in patients with congenital factor VII deficiency. Haemophilia 17:713-715.
http://www.ncbi.nlm.nih.gov/pubmed/21299748

Jiang M, Wang Z, Yu Z, Bai X, Su J, Cao L, . . . Ruan C (2011) A novel missense mutation close to the charge-stabilizing system in a patient with congenital factor VII deficiency. Blood Coagul Fibrinolysis 22:264-270.
http://www.ncbi.nlm.nih.gov/pubmed/21372693

Jiang R, Wang NP, Tanaka KA, Levy JH, Guyton RA, Zhao ZQ, Vinten-Johansen J (2011) Factor Xa induces tissue factor expression in endothelial cells by P44/42 MAPK and NF-kappaB-dependent pathways. J Surg Res 169:319-327.
http://www.ncbi.nlm.nih.gov/pubmed/20451919

Kassel KM, Owens Iii AP, Rockwell CE, Sullivan BP, Wang R, Tawfik O, . . . Luyendyk JP (2011) Protease-Activated Receptor 1 and Hematopoietic Cell Tissue Factor Are Required for Hepatic Steatosis in Mice Fed a High-Fat Diet. Am J Pathol.
http://www.ncbi.nlm.nih.gov/pubmed/21907177

Kostovski E, Dahm AE, Iversen N, Hjeltnes N, Osterud B, Sandset PM, Iversen PO (2011) Melatonin stimulates release of tissue factor pathway inhibitor from the vascular endothelium. Blood Coagul Fibrinolysis 22:254-259.
http://www.ncbi.nlm.nih.gov/pubmed/21297449

Kresge N, Simoni RD, Hill RL (2011) Blood clotting and coagulation factors: the work of Yale Nemerson. 1980, 1982. J Biol Chem 286:e5-6.
http://www.ncbi.nlm.nih.gov/pubmed/21842549

Layland J, Ray MJ, Siresena T, Walters DL (2011) Increased expression of monocyte tissue factor and soluble CD40 ligand at mid-term follow-up following percutaneous coronary intervention. Blood Coagul Fibrinolysis 22:349-350.
http://www.ncbi.nlm.nih.gov/pubmed/21546798

Liu Y, Jiang P, Capkova K, Xue D, Ye L, Sinha SC, . . . Liu C (2011) Tissue Factor Activated Coagulation Cascade in The Tumor Microenvironment Is Critical For Tumor Progression And an Effective Target For Therapy. Cancer Res.
http://www.ncbi.nlm.nih.gov/pubmed/21880589

Masotti L, Di Napoli M, Godoy DA, Rafanelli D, Liumbruno G, Koumpouros N, . . . Prisco D (2011) The practical management of intracerebral hemorrhage associated with oral anticoagulant therapy. Int J Stroke 6:228-240.
http://www.ncbi.nlm.nih.gov/pubmed/21557810

Mirzaahmadi S, Asaadi-Tehrani G, Bandehpour M, Davoudi N, Tahmasbi L, Hosseinzadeh N, . . . Kazemi B (2011) Expression of Recombinant Human Coagulation Factor VII by the Lizard Leishmania Expression System. J Biomed Biotechnol 2011:873874.
http://www.ncbi.nlm.nih.gov/pubmed/21912483

Neufeld EJ, Kessler CM, Gill JC, Wilke CT, Cooper DL (2011) Exposure and safety of higher doses of recombinant factor VIIa >/=250 mug kg(-1) in individuals with congenital haemophilia complicated by alloantibody inhibitors: the Haemophilia and Thrombosis Research Society Registry experience (2004-2008). Haemophilia 17:650-656.
http://www.ncbi.nlm.nih.gov/pubmed/21299750

Newell-Caito JL, Laha M, Tharp AC, Creamer JI, Xu H, Maddur AA, . . . Bock PE (2011) Notecarin D binds human factor V and factor Va with high affinity in the absence of membranes. J Biol Chem.
http://www.ncbi.nlm.nih.gov/pubmed/21911491

Ogiwara K, Nogami K, Shima M (2011) Factor VIII activation by factor VIIa analog V158D/E296V/M298Q) in tissue factor-independent mechanisms. Thromb Haemost 106.
http://www.ncbi.nlm.nih.gov/pubmed/21901232

Phillips A (2011) Off-Label Use of Recombinant Factor VIIa. Ann Intern Med 155:337.
http://www.ncbi.nlm.nih.gov/pubmed/21893633

Piek CJ, Brinkhof B, Teske E, Rothuizen J, Dekker A, Penning LC (2011) High intravascular tissue factor expression in dogs with idiopathic immune-mediated haemolytic anaemia. Vet Immunol Immunopathol.
http://www.ncbi.nlm.nih.gov/pubmed/21899896

Sen P, Nayak R, Clark CA, Gopalakrishnan R, Esmon CT, Pendurthi UR, Rao LV (2011) Factor X binding to endothelial cell protein C receptor: comparison with factor VIIa and activated protein C. Blood 118:2635-2636.
http://www.ncbi.nlm.nih.gov/pubmed/21885613

Steiner T, Vincent C, Morris S, Davis S, Vallejo-Torres L, Christensen MC (2011) Neurosurgical outcomes after intracerebral hemorrhage: results of the Factor Seven for Acute Hemorrhagic Stroke Trial (FAST). J Stroke Cerebrovasc Dis 20:287-294.
http://www.ncbi.nlm.nih.gov/pubmed/20452785

Tiede A, Rand JH, Budde U, Ganser A, Federici AB (2011) How I treat the acquired von Willebrand syndrome. Blood 117:6777-6785.
http://www.ncbi.nlm.nih.gov/pubmed/21540459

Tong Y, Zhou J, Mao M, Gao J, Yuan L (2011) Generation of bioactive recombinant Ancylostoma caninum anticoagulant peptide c2. Protein Expr Purif.
http://www.ncbi.nlm.nih.gov/pubmed/21907287

Valentino LA, Cooper DL, Goldstein B (2011) Surgical experience with rFVIIa (NovoSeven) in congenital haemophilia A and B patients with inhibitors to factors VIII or IX. Haemophilia 17:579-589.
http://www.ncbi.nlm.nih.gov/pubmed/21294815

van den Berg YW, Reitsma PH (2011) Not Exclusively Tissue Factor: NETs Provide Another Link Between Chemotherapy and Thrombosis. J Thromb Haemost.
http://www.ncbi.nlm.nih.gov/pubmed/21910822

Van Dreden P, Woodhams B, Rousseau A, Favier M, Favier R (2011) Comparative evaluation of Tissue factor and Thrombomodulin activity changes during normal and idiopathic early and late foetal loss: The cause of hypercoagulability? Thromb Res.
http://www.ncbi.nlm.nih.gov/pubmed/21880353

Winckers K, Siegerink B, Duckers C, Maurissen LM, Tans G, Castoldi E, . . . Rosendaal FR (2011) Increased Tissue Factor Pathway Inhibitor Activity is Associated with Myocardial Infarction in Young Women; Results From the Ratio Study. J Thromb Haemost.
http://www.ncbi.nlm.nih.gov/pubmed/21895962

Xu G, Wen H, Zhou H, Guo D, Zhou F, Chen D, . . . Wang H (2011) Involvement of IRAKs and TRAFs in anti-beta2GPI/ beta2GPI-induced tissue factor expression in THP-1 cells. Thromb Haemost 106.
http://www.ncbi.nlm.nih.gov/pubmed/21901230

Xu GY, Zhou H, Wen HP, Guo DL, Zhou F, Chen DD, Xie HX (2011) [Activation of tumor necrosis factor receptor-associated factor 6 in anti-beta2GPI/beta2GPI-induced tissue factor expression on THP-1 cells]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 27:487-490.
http://www.ncbi.nlm.nih.gov/pubmed/21557901
__________________________________________________________

Vol. 17, No. 17

noreply@blogger.com (Pierre) — Thu, 01 Sep 2011 22:29:00 +0000

TRIGGER
The Twice-Monthly Electronic Newsletter on the Biology of Tissue Factor, Factor VII and TFPI
Vol. 17, No. 17 September 1, 2011

(The next issue will be on September 15, 2011)

__________________________________________________________
TRIGGER is also available by RSS Feed:

http://feeds.feedburner.com/blogspot/glro

and BLOG:
http://trigger-tf7.blogspot.com/
__________________________________________________________

PAPERS IN PRESS

None submitted for this issue.

__________________________________________________________

POSITIONS SOUGHT/AVAILABLE

The Centre for Thrombosis and Hemostasis (CTH) of the University Medical Centre Mainz is a model center to improve the integration of education, research and patient care with a translational focus. It is funded by the Federal Ministry of Education and Research (BMBF) in the framework of the national program "Integrierte Forschungs- und Behandlungszentren" (Integrated Research and Treatment Centers) (IFB). In addition to improve clinical research by specific funding of translational structures with a focus on thrombosis and hemostasis, the creation of better work conditions as well as career opportunities with a focus on equal opportunities and family are among our objectives.

We currently have to fill three junior group leader positions. For the purposes of equal opportunities, we are actively looking for qualified female scientists who might be interested in those positions. You can find information about the CTH on our website:

http://www.cth-mainz.de/

Should you require further information please do not hesitate to contact us.

Verena Stange

Centrum für Thrombose und Hämostase (CTH)

UNIVERSITÄTSMEDIZIN

der Johannes Gutenberg-Universität Mainz

Langenbeckstraße 1

Geb. 403, 1. OG, Zim. 126

55131 Mainz

E-Mail: verena DOT stange AT unimedizin-mainz DOT de

__________________________________________________________

RECENT PUBLICATIONS ON TISSUE FACTOR, FACTOR VII, AND TFPI

THE FOLLOWING LINK WILL TAKE YOU TO THE ENTIRE LIST OF THIS ISSUE'S PUBLICATIONS IN A PUBMED "COLLECTION":

http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/1dOqVon-A-n6swLXXAQE9Y3/

Arderiu G, Pena E, Aledo R, Juan-Babot O, Badimon L (2011) Tissue Factor Regulates Microvessel Formation and Stabilization by Induction of CCL2 Expression. Arterioscler Thromb Vasc Biol.

http://www.ncbi.nlm.nih.gov/pubmed/21868706

Barcelo A, Pierola J, de la Pena M, Esquinas C, Sanchez-de la Torre M, Ayllon O, . . . Barbe F (2011) Day- night variations in endothelial dysfunction markers and haemostatic factors in sleep apnoea. Eur Respir J.

http://www.ncbi.nlm.nih.gov/pubmed/21852330

Henriksson CE, Hellum M, Haug KB, Aass HC, Joo GB, Ovstebo R, . . . Kierulf P (2011) Anticoagulant effects of an antidiabetic drug on monocytes in vitro. Thromb Res.

http://www.ncbi.nlm.nih.gov/pubmed/21862110

Krysiak R, Gdula-Dymek A, Okopien B (2011) Hemostatic effects of bezafibrate and omega-3 fatty acids in isolated hypertriglyceridemic patients. Pharmacol Rep 63:763-771.

http://www.ncbi.nlm.nih.gov/pubmed/21857087

Lhermusier T, Van Rottem J, Garcia C, Xuereb JM, Ragab A, Martin V, . . . Payrastre B (2011) The Syk-Kinase Inhibitor R406 Impairs Platelet Activation and Monocyte Tissue Factor Expression Triggered by Heparin-PF4 Complex Directed Antibodies. J Thromb Haemost.

http://www.ncbi.nlm.nih.gov/pubmed/21848694

Lupu C, Zhu H, Popescu NI, Wren JD, Lupu F (2011) Novel protein ADTRP regulates TFPI expression and function in human endothelial cells in normal conditions and in response to androgen. Blood.

http://www.ncbi.nlm.nih.gov/pubmed/21868574

Mo X, Hao Y, Yang X, Chen S, Lu X, Gu D (2011) Association between polymorphisms in the coagulation factor VII gene and coronary heart disease risk in different ethnicities: a meta-analysis. BMC Med Genet 12:107.

http://www.ncbi.nlm.nih.gov/pubmed/21838885

Nagle EL, Tsu LV, Dager WE (2011) Bivalirudin for Anticoagulation During Hypothermic Cardiopulmonary Bypass and Recombinant Factor VIIa for Iatrogenic Coagulopathy (September). Ann Pharmacother.

http://www.ncbi.nlm.nih.gov/pubmed/21862711

Napoleone E, Cutrone A, Cugino D, Latella MC, Zurlo F, Iacoviello L, . . . Lorenzet R (2011) Leptin upregulates tissue factor expression in human breast cancer MCF-7 cells. Thromb Res.

http://www.ncbi.nlm.nih.gov/pubmed/21840575

Pinotti M, Bernardi F, Dal Mas A, Pagani F (2011) Rna-Based Therapeutic Approaches for Coagulation Factor Deficiencies. J Thromb Haemost.

http://www.ncbi.nlm.nih.gov/pubmed/21854538

Schafer K, Konstantinides S (2011) Adipokines and Thrombosis. Clin Exp Pharmacol Physiol.

http://www.ncbi.nlm.nih.gov/pubmed/21848866

Stavik B, Skretting G, Aasheim HC, Tinholt M, Zernichow L, Sletten M, . . . Iversen N (2011) Downregulation of TFPI in breast cancer cells induces tyrosine phosphorylation signaling and increases metastatic growth by stimulating cell motility. BMC Cancer 11:357.

http://www.ncbi.nlm.nih.gov/pubmed/21849050

Trappenburg MC, van Schilfgaarde M, Frerichs FC, Spronk HM, Ten Cate H, de Fijter CW, . . . Leyte A (2011) Chronic renal failure is accompanied by endothelial activation and a large increase in microparticle numbers with reduced procoagulant capacity. Nephrol Dial Transplant.

http://www.ncbi.nlm.nih.gov/pubmed/21873622

Williams L, Tucker TA, Koenig K, Allen T, Rao LV, Pendurthi U, Idell S (2011) Tissue Factor Pathway Inhibitor Attenuates the Progression of Malignant Pleural Mesothelioma in Nude Mice. Am J Respir Cell Mol Biol.

http://www.ncbi.nlm.nih.gov/pubmed/21868710

Zhao X, Dong S, Wang J, Li F, Chen A, Li B (2011) A comparative study of antithrombotic and antiplatelet activities of different fucoidans from Laminaria japonica. Thromb Res.

http://www.ncbi.nlm.nih.gov/pubmed/21872298

__________________________________________________________

Vol. 17, No. 16

noreply@blogger.com (Pierre) — Mon, 15 Aug 2011 19:04:00 +0000

TRIGGER
The Twice-Monthly Electronic Newsletter on the Biology of Tissue Factor, Factor VII and TFPI
Vol. 17, No. 16 August 15, 2011

(The next issue will be on September 1, 2011)

__________________________________________________________
TRIGGER is also available by RSS Feed:
http://feeds.feedburner.com/blogspot/glro
and BLOG:
http://trigger-tf7.blogspot.com/
__________________________________________________________
PAPERS IN PRESS
None submitted for this issue.
__________________________________________________________
RECENT PUBLICATIONS ON TISSUE FACTOR, FACTOR VII, AND TFPI
Papers are culled from NLM MedLine (PubMed). Titles in square brackets indicate that the paper was not published in English. References that lack volume or page numbers are typically electronic pre-publications (E-pubs) ahead of the print publication; if so, the final citation with volume and page numbers may or may not appear in a future issue of Trigger.

THE FOLLOWING LINK WILL TAKE YOU TO THE ENTIRE LIST OF THIS ISSUE'S PUBLICATIONS IN A PUBMED "COLLECTION":

http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/1xgVk69whtpFQgRX80ckXWp/

Ahmad S, Ansari AA (2011) Therapeutic Roles of Heparin Anticoagulants in Cancer and Related Disorders. Med Chem.

http://www.ncbi.nlm.nih.gov/pubmed/21801147

Bhatia P (2011) Use of recombinant factor VIIa in orthotopic liver transplant. Indian J Anaesth 55:309-310.

http://www.ncbi.nlm.nih.gov/pubmed/21808412

Chavez-Tapia NC, Alfaro-Lara R, Tellez-Avila F, Barrientos-Gutierrez T, Gonzalez-Chon O, Mendez-Sanchez N, Uribe M (2011) Prophylactic Activated Recombinant Factor VII in Liver Resection and Liver Transplantation: Systematic Review and Meta-Analysis. PLoS One 6:e22581.

http://www.ncbi.nlm.nih.gov/pubmed/21818342

Chrysanthopoulou A, Mitroulis I, Kambas K, Skendros P, Kourtzelis I, Vradelis S, . . . Ritis K (2011) Tissue factor-thrombin signaling enhances the fibrotic activity of myofibroblasts in systemic sclerosis through endothelin-1 receptor A up-regulation. Arthritis Rheum.

http://www.ncbi.nlm.nih.gov/pubmed/21834070

Collins PW (2011) Management of acquired haemophilia A. J Thromb Haemost 9 Suppl 1:226-235.

http://www.ncbi.nlm.nih.gov/pubmed/21781259

Corrales-Rodriguez L, Blais N (2011) Lung cancer associated venous thromboembolic disease: A comprehensive review. Lung Cancer.

http://www.ncbi.nlm.nih.gov/pubmed/21820753

Esmon CT, Xu J, Lupu F (2011) Innate immunity and coagulation. J Thromb Haemost 9 Suppl 1:182-188.

http://www.ncbi.nlm.nih.gov/pubmed/21781254

Fischer TH, Nichols TC, Scull CM, Smith CJ, Demcheva M (2011) Poly-N-Acetylglucosamine Fibers Amplify the Effectiveness of Recombinant Factor VIIA on Clot Formation in Hemophilia B Canine Blood. J Trauma 71:S171-175.

http://www.ncbi.nlm.nih.gov/pubmed/21814114

Hayashi M, Takeshita K, Inden Y, Ishii H, Cheng XW, Yamamoto K, Murohara T (2011) Platelet activation and induction of tissue factor in acute and chronic atrial fibrillation: Involvement of mononuclear cell-platelet interaction. Thromb Res.

http://www.ncbi.nlm.nih.gov/pubmed/21824645

Heying R, Wolf C, Beekhuizen H, Moelleken ML, Jockenhoevel S, Hoylaerts MF, . . . Schroten H (2011) Fibrin- and collagen-based matrices attenuate inflammatory and procoagulant responses in human endothelial cell cultures exposed to S. aureus. Tissue Eng Part A.

http://www.ncbi.nlm.nih.gov/pubmed/21806488

Khanna S, Schwartz MH, Ruggiero SL (2011) Factor VII Deficiency Resulting in Acute Hemorrhage in Orthognathic Surgery: A Case Report. J Oral Maxillofac Surg.

http://www.ncbi.nlm.nih.gov/pubmed/21821330

Knudsen T, Kjalke M, Tranholm M, Nichols TC, Jensen AL, Kristensen AT (2011) Development of a flow cytometric assay for detection of coated platelets in dogs and evaluation of binding of coated platelets to recombinant human coagulation factor VIIa. Am J Vet Res 72:1007-1014.

http://www.ncbi.nlm.nih.gov/pubmed/21801056

Lemon SJ, Jr., Crannage AJ (2011) Pharmacologic anticoagulation reversal in the emergency department. Adv Emerg Nurs J 33:212-223.

http://www.ncbi.nlm.nih.gov/pubmed/21836448

Levi M, van der Poll T, Schultz M (2011) Systemic versus localized coagulation activation contributing to organ failure in critically ill patients. Semin Immunopathol.

http://www.ncbi.nlm.nih.gov/pubmed/21805225

Pacheco LD, Saade GR, Gei AF, Hankins GD (2011) Cutting-edge advances in the medical management of obstetrical hemorrhage. Am J Obstet Gynecol.

http://www.ncbi.nlm.nih.gov/pubmed/21816382

Pokras SM, Petrilla AA, Weatherall J, Lee WC (2011) The economics of inpatient on-demand treatment for haemophilia with high-responding inhibitors: a US retrospective data analysis. Haemophilia.

http://www.ncbi.nlm.nih.gov/pubmed/21812862

Priya N, Singh P, Bhatia S, Medhi B, Prasad AK, Parmar VS, Raj HG (2011) Characterization of a unique dihydropyrimidinone, ethyl 4-(4'-heptanoyloxyphenyl)-6-methyl-3,4-dihydropyrimidin-2-one-5-carboxylate, as an effective antithrombotic agent in a rat experimental model. J Pharm Pharmacol 63:1175-1185.

http://www.ncbi.nlm.nih.gov/pubmed/21827490

Pychynska-Pokorska M, Pagowska-Klimek I, Krajewski W, Moll JJ (2011) Use of Recombinant Activated Factor VII for Controlling Refractory Postoperative Bleeding in Children Undergoing Cardiac Surgery With Cardiopulmonary Bypass. J Cardiothorac Vasc Anesth.

http://www.ncbi.nlm.nih.gov/pubmed/21835642

Riddell A, Abdul-Kadir R, Pollard D, Tuddenham E, Gomez K (2011) Monitoring low dose recombinant factor VIIa therapy in patients with severe factor XI deficiency undergoing surgery. Thromb Haemost 106.

http://www.ncbi.nlm.nih.gov/pubmed/21833443

Ruf W, Disse J, Carneiro-Lobo TC, Yokota N, Schaffner F (2011) Tissue factor and cell signalling in cancer progression and thrombosis. J Thromb Haemost 9 Suppl 1:306-315.

http://www.ncbi.nlm.nih.gov/pubmed/21781267

Srinivasan R, Ozhegov E, van den Berg YW, Aronow BJ, Franco RS, Palascak MB, . . . Bogdanov VY (2011) Splice Variants of Tissue Factor Promote Monocyte-Endothelial Interactions by Triggering the Expression of Cell Adhesion Molecules via Integrin-Mediated Signaling. J Thromb Haemost.

http://www.ncbi.nlm.nih.gov/pubmed/21812913

Stokol T, Daddona JL, Mubayed LS, Trimpert J, Kang S (2011) Evaluation of tissue factor expression in canine tumor cells. Am J Vet Res 72:1097-1106.

http://www.ncbi.nlm.nih.gov/pubmed/21801068

Undas A, Slowik A, Gissel M, Mann KG, Butenas S (2011) Circulating activated factor XI and active tissue factor as predictors of worse prognosis in patients following ischemic cerebrovascular events. Thromb Res.

http://www.ncbi.nlm.nih.gov/pubmed/21820158

Wang AY, Yuan A, Huang CH, Chang WT, Liang PC, Lin TH, Chen SC (2011) Recombinant factor VIIa use in refractory ulcer bleeding in uremic patient. Am J Emerg Med.

http://www.ncbi.nlm.nih.gov/pubmed/21802887

Weatherall J, Barnes N, Brown C, Preaud E (2011) Future characteristics of bypassing agents to improve care of hemophilia inhibitor patients: an economic and health-related quality of life perspective. Expert Rev Pharmacoecon Outcomes Res 11:411-414.

http://www.ncbi.nlm.nih.gov/pubmed/21831021

Weiler H (2011) Multiple receptor-mediated functions of activated protein C. Hamostaseologie 31:185-195.

http://www.ncbi.nlm.nih.gov/pubmed/21826371

Zhu W, Lv Q, Chen H, Wang Z, Zhong Q (2011) Protective effect and mechanism of sodium tanshinone II A sulfonate on microcirculatory disturbance of small intestine in rats with sepsis. J Huazhong Univ Sci Technolog Med Sci 31:441-445.

http://www.ncbi.nlm.nih.gov/pubmed/21823002

__________________________________________________________

Vol. 17, No. 15

noreply@blogger.com (Pierre) — Mon, 01 Aug 2011 19:34:00 +0000

TRIGGER
The Twice-Monthly Electronic Newsletter on the Biology of Tissue Factor, Factor VII and TFPI
Vol. 17, No. 15 August 1, 2011
(The next issue will be on August 15, 2011)
__________________________________________________________
TRIGGER is also available by RSS Feed:
http://feeds.feedburner.com/blogspot/glro
and BLOG:
http://trigger-tf7.blogspot.com/
__________________________________________________________
PRODUCT ANNOUNCEMENT

The Staclot VIIa-rTF product from Diagnostica Stago, Inc. (catalog #00281) is a kit for plasma analysis of circulating factor VIIa (FVIIa) by a clotting method. It can be run on any instrument reporting clotting times, and is labeled for research use only, not for use in diagnostic procedures worldwide.

This unique product is useful for the determination of FVIIa levels in various disease states such as liver disease (1) and combined hyperlipidemia (2) due to the fact that it reflects coagulation activation as a result of in vivo FVIIa production. Specifically, Staclot VIIa-rTF measurements correlated with liver disease stage (1), degree of lipemia (2) and age (3). In addition, specific determinants of genotype specific FVII levels, such as oral contraception have been analyzed (4). NovoSeven® levels in hemophilia research subjects can also be examined (5-6). Further, Staclot VIIa-rTF was a reliable method for analyzing FVIIa levels in patients given low doses of NovoSeven® (6).

For more information, please contact Paul Riley, PhD; 973-631-1200 x4238, (paul DOT riley AT stago-us DOT com).

E. Rodriguez-Inigo et al., Blood Coagul Fibrinolysis 12, 193 (Apr, 2001).
A. Nordoy, B. Svensson, J. B. Hansen, J Thromb Haemost 1, 690 (Apr, 2003).
G. Mariani et al., Haematologica 84, 620 (Jul, 1999).
G. Mariani, J. Conard, R. M. Bertina, V. Garcia, et al., Arterioscler Thromb Vasc Biol 19, 2024(1999).
G. T. Gerotziafas et al., Br J Haematol 117, 705 (Jun, 2002).
M. Johannessen, G. Nielsen, O. Nordfang, Blood Coagul Fibrinolysis 11 Suppl 1, S159 (Apr, 2000).

DISCLAIMER: Commercial product announcements appearing in TRIGGER are provided "as is" for informational purposes only. The editors of TRIGGER have not necessarily evaluated any materials from commercial suppliers described in this newsletter or on its web sites, and we certainly are not endorsing any specific suppliers or products. Furthermore, the editors receive no revenues from any source in the course of publishing TRIGGER.

__________________________________________________________
PAPERS IN PRESS
AUTHORS: Napoleone E, Cutrone A, Cugino D, Latella MC, Zurlo F, Iacoviello L, de Gaetano G, Donati MB, Lorenzet R.
TITLE: Leptin upregulates tissue factor expression in human breast cancer MCF-7 cells
JOURNAL: Thrombosis Research
ABSTRACT: Introduction: Obesity is a risk factor for both cardiovascular disease and cancer development. Leptin, a cytokine produced by adipose tissue, controls different processes in peripheral tissues, including cancer development and thrombotic disorders in patients with a variety of clinical disorders. Tissue factor (TF), the trigger of blood clotting, is abundant in the adipose tissue.
Since TF, often expressed by cancer cells, is considered a hallmark of cancer progression, we investigated whether leptin could modulate TF in the human metastatic breast carcinoma cell line MCF-7.
Materials and Methods: MCF-7 cells were incubated with or without the different reagents at 37°C. At the end of incubation, cells were tested for procoagulant activity by a one-stage clotting assay, TF and TNF- antigen levels and mRNA by ELISA and real-time RT-PCR, respectively. Leptin receptor was studied by FACS.
Results: Both TF activity and antigen constitutively expressed by MCF-7 were significantly increased by leptin in a dose-dependent fashion. TF mRNA levels were also enhanced indicating that leptin exerts its effect at the transcription level. The effect of leptin was specific and required binding to its receptor (Ob-R), which was found on the surface of the cells, since antibodies against leptin and Ob-R completely prevented TF expression upregulation.
In addition, leptin enhanced both TNF- mRNA synthesis and secretion from MCF7. An anti-TNF- MoAb completely abolished the leptin-induced TF expression.
Conclusions: These data support the hypothesis that leptin, by its upregulation of TF, possibly mediated by TNF- synthesis, may contribute to processes underlying both cancer and vascular cell disorders.

SUBMITTED BY: Dr. Roberto Lorenzet: roberto DOT lorenzet AT rm DOT unicatt DOT it
__________________________________________________________
RECENT PUBLICATIONS ON TISSUE FACTOR, FACTOR VII, AND TFPI
Papers are culled from NLM MedLine (PubMed). Titles in square brackets indicate that the paper was not published in English. References that lack volume or page numbers are typically electronic pre-publications (E-pubs) ahead of the print publication; if so, the final citation with volume and page numbers may or may not appear in a future issue of Trigger.
THE FOLLOWING LINK WILL TAKE YOU TO THE ENTIRE LIST OF THIS ISSUE'S PUBLICATIONS IN A PUBMED "COLLECTION":
http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/1ngfxm5CxmdaJsicqVdPhrS/

Boles JC, Williams JC, Hollingsworth RM, Wang JG, Glover SL, Owens AP, 3rd, . . . Mackman N (2011) Anthracycline treatment of the human monocytic leukemia cell line THP-1 increases phosphatidylserine exposure and tissue factor activity. Thromb Res.
http://www.ncbi.nlm.nih.gov/pubmed/21762960

Ensley AE, Nerem RM, Anderson DE, Hanson SR, Hinds MT (2011) Fluid Shear Stress Alters the Coagulation Potential of Endothelial Outgrowth Cells. Tissue Eng Part A.
http://www.ncbi.nlm.nih.gov/pubmed/21787250

Ganguly K, Upadhyay S, Irmler M, Takenaka S, Pukelsheim K, Beckers J, . . . Schulz H (2011) Impaired resolution of inflammatory response in the lungs of JF1/Msf mice following carbon nanoparticle instillation. Respir Res 12:94.
http://www.ncbi.nlm.nih.gov/pubmed/21756372

Hemmeryckx B, Van Hove CE, Fransen P, Emmerechts J, Kauskot A, Bult H, . . . Hoylaerts MF (2011) Progression of the Prothrombotic State in Aging Bmal1-Deficient Mice. Arterioscler Thromb Vasc Biol.
http://www.ncbi.nlm.nih.gov/pubmed/21799179

Horowitz NA, Blevins EA, Miller WM, Perry AR, Talmage KE, Mullins ES, . . . Palumbo JS (2011) Thrombomodulin is a determinant of metastasis through a mechanism linked to the thrombin binding domain but not the lectin-like domain. Blood.
http://www.ncbi.nlm.nih.gov/pubmed/21788337

Johansson PI, Stensballe J, Rasmussen LS, Ostrowski SR (2011) A high admission syndecan-1 level, a marker of endothelial glycocalyx degradation, is associated with inflammation, protein C depletion, fibrinolysis, and increased mortality in trauma patients. Ann Surg 254:194-200.
http://www.ncbi.nlm.nih.gov/pubmed/21772125

Jordan SW, Chaikof EL (2011) Simulated surface-induced thrombin generation in a flow field. Biophys J 101:276-286.
http://www.ncbi.nlm.nih.gov/pubmed/21767479

Karkouti K, Levy JH (2011) Recombinant Activated Factor VII: The Controversial Conundrum Regarding Its Off-Label Use. Anesth Analg.
http://www.ncbi.nlm.nih.gov/pubmed/21788315

Langer F, Bokemeyer C (2011) Crosstalk between cancer and haemostasis. Implications for cancer biology and cancer-associated thrombosis with focus on tissue factor. Hamostaseologie 31.
http://www.ncbi.nlm.nih.gov/pubmed/21792469

Le Noel A, Merat S, Ausset S, De Rudnicki S, Mion G (2011) [The damage control resuscitation concept.]. Ann Fr Anesth Reanim.
http://www.ncbi.nlm.nih.gov/pubmed/21764247

Lima LG, Oliveira AS, Campos LC, Bonamino M, Chammas R, Werneck C, . . . Monteiro RQ (2011) Malignant transformation in melanocytes is associated with increased production of procoagulant microvesicles. Thromb Haemost 106.
http://www.ncbi.nlm.nih.gov/pubmed/21800005

Moertl D, Berger R, Hammer A, Hutuleac R, Koppensteiner R, Kopp CW, Steiner S (2011) Dose-dependent decrease of platelet activation and tissue factor by omega-3 polyunsaturated fatty acids in patients with advanced chronic heart failure. Thromb Haemost 106.
http://www.ncbi.nlm.nih.gov/pubmed/21800004

Nie XM, Zhou YJ, Li YF, Xie Y, Su LX (2011) [Effects of sirolimus upon endothelial thrombotic function of human umbilical vein endothelial cells]. Zhonghua Yi Xue Za Zhi 91:1281-1284.
http://www.ncbi.nlm.nih.gov/pubmed/21756803

Nosari A, Caimi TM, Zilioli V, Molteni A, Mancini V, Morra E (2011) Cerebral Hemorrhage Treated with Novoseven in Acute Promyelocytic Leukemia. Leuk Lymphoma.
http://www.ncbi.nlm.nih.gov/pubmed/21780994

Quezada M, Diaz J, Henriquez S, Bravo ML, Aranda E, Oliva B, . . . Owen GI (2010) 2-methoxyestradiol inhibits progesterone-dependent tissue factor expression and activity in breast cancer cells. Horm Cancer 1:117-126.
http://www.ncbi.nlm.nih.gov/pubmed/21761355

Sorensen B, Dargaud Y, Kenet G, Lusher J, Mumford A, Pipe S, Tiede A (2011) On-demand treatment of bleeds in haemophilia patients with inhibitors: strategies for securing and maintaining predictable efficacy with recombinant activated factor VII. Haemophilia.
http://www.ncbi.nlm.nih.gov/pubmed/21771206

Svensson KJ, Kucharzewska P, Christianson HC, Skold S, Lofstedt T, Johansson MC, . . . Belting M (2011) Hypoxia triggers a proangiogenic pathway involving cancer cell microvesicles and PAR-2-mediated heparin-binding EGF signaling in endothelial cells. Proc Natl Acad Sci U S A.
http://www.ncbi.nlm.nih.gov/pubmed/21788507

Teruel R, Perez-Sanchez C, Corral J, Herranz MT, Perez-Andreu V, Saiz E, . . . Martinez C (2011) Identification of miRNAs as Potential Modulators of Tissue Factor Expression in Patients with Systemic Lupus Erythematosus and Antiphospholipid Syndrome. J Thromb Haemost.
http://www.ncbi.nlm.nih.gov/pubmed/21794077

Trompet S, Pons D, Kanse SM, de Craen AJ, Ikram MA, Verschuren JJ, . . . Jukema JW (2011) Factor VII Activating Protease Polymorphism (G534E) Is Associated with Increased Risk for Stroke and Mortality. Stroke Res Treat 2011:424759.
http://www.ncbi.nlm.nih.gov/pubmed/21789270

Tse EY, Cheung WY, Ng KF, Luk KD (2011) Reducing perioperative blood loss and allogeneic blood transfusion in patients undergoing major spine surgery. J Bone Joint Surg Am 93:1268-1277.
http://www.ncbi.nlm.nih.gov/pubmed/21776581

Versteeg HH, Ruf W (2011) Thiol pathways in the regulation of tissue factor prothrombotic activity. Curr Opin Hematol.
http://www.ncbi.nlm.nih.gov/pubmed/21778880

Witting PK, Song C, Hsu K, Hua S, Parry SN, Aran R, . . . Freedman SB (2011) The acute-phase protein serum amyloid A induces endothelial dysfunction that is inhibited by high-density lipoprotein. Free Radic Biol Med.
http://www.ncbi.nlm.nih.gov/pubmed/21784147

Zahra S, Anderson JA, Stirling D, Ludlam CA (2011) Plasma microparticles are not elevated in fresh plasma from patients with gynaecological malignancy - An observational study. Gynecol Oncol.
http://www.ncbi.nlm.nih.gov/pubmed/21777967

Zheng XW, Kudaravalli R, Russell TT, Dimichele DM, Gibb C, Russell JE, . . . Pollak ES (2011) Mutation in the factor VII hepatocyte nuclear factor 4alpha-binding site contributes to factor VII deficiency. Blood Coagul Fibrinolysis.
http://www.ncbi.nlm.nih.gov/pubmed/21760481
__________________________________________________________
ABOUT TRIGGER
TRIGGER is edited by Jim Morrissey and Pierre Neuenschwander, with editorial assistance by Genie Morrissey. It includes Abstracts of Papers in Press, Meeting Announcements, Positions Sought/Available,or any other pertinent item that subscribers may want to share with their colleagues. To submit an item for publication in Trigger, e-mail us. To request or cancel a subscription,or for more information about TRIGGER or the biology of tissue factor and factor VII, visit our web site. You can also contact us by mail: J.H. Morrissey, University of Illinois College of Medicine, 417 Med Sci Bldg MC-714, 506 S. Mathews Ave., Urbana, IL 61801, USA.

Vol. 17, No. 14

noreply@blogger.com (Pierre) — Fri, 15 Jul 2011 21:34:00 +0000

TRIGGER
The Twice-Monthly Electronic Newsletter on the Biology of Tissue Factor, Factor VII and TFPI
Vol. 17, No. 14 July 15, 2011
(The next issue will be on August 1, 2011)
__________________________________________________________
TRIGGER is also available by RSS Feed:
http://feeds.feedburner.com/blogspot/glro
and BLOG:
http://trigger-tf7.blogspot.com/
__________________________________________________________
PAPERS IN PRESS
None submitted for this issue.
__________________________________________________________
RECENT PUBLICATIONS ON TISSUE FACTOR, FACTOR VII, AND TFPI
Papers are culled from NLM MedLine (PubMed). Titles in square brackets indicate that the paper was not published in English. References that lack volume or page numbers are typically electronic pre-publications (E-pubs) ahead of the print publication; if so, the final citation with volume and page numbers may or may not appear in a future issue of Trigger.
THE FOLLOWING LINK WILL TAKE YOU TO THE ENTIRE LIST OF THIS ISSUE'S PUBLICATIONS IN A PUBMED "COLLECTION":
http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/1H5wq9jvpxdU-2RotATf8pf/

Bechtel BF, Nunez TC, Lyon JA, Cotton BA, Barrett TW (2011) Treatments for reversing warfarin anticoagulation in patients with acute intracranial hemorrhage: a structured literature review. Int J Emerg Med 4:40.
http://www.ncbi.nlm.nih.gov/pubmed/21740550

Bobbert P, Eisenreich A, Weithauser A, Schultheiss HP, Rauch U (2011) Leptin and resistin induce increased procoagulability in diabetes mellitus. Cytokine.
http://www.ncbi.nlm.nih.gov/pubmed/21733717

Camire RM (2011) A new look at blood coagulation factor V. Curr Opin Hematol.
http://www.ncbi.nlm.nih.gov/pubmed/21730834

Cervera A, Amaro S, Chamorro A (2011) Oral anticoagulant-associated intracerebral hemorrhage. J Neurol.
http://www.ncbi.nlm.nih.gov/pubmed/21748282

Cheng S, Jiang Z, Zou Y, Chen C, Wang Y, Liu Y, . . . Wang Z (2011) Downregulation of Clock in circulatory system leads to an enhancement of fibrinolysis in mice. Exp Biol Med (Maywood).
http://www.ncbi.nlm.nih.gov/pubmed/21750017

Imberti R, Pietrobono L, Klersy C, Gamba G, Iotti G, Cornara G (2011) Intraoperative intravenous administration of rFVIIa and hematoma volume after early surgery for spontaneous intracerebral hemorrhage: a randomized prospective phase II study. Minerva Anestesiol.
http://www.ncbi.nlm.nih.gov/pubmed/21750485

Jan JY, Lin SY, Lin CH, Lee CN, Fan SZ, Han YY (2011) Recombinant activated factor VII as a promising adjuvant therapy for postpartum hemorrhage in the practice of obstetric anesthesia: Experience from a university hospital in Taiwan. J Obstet Gynaecol Res 37:901-907.
http://www.ncbi.nlm.nih.gov/pubmed/21736669

Kakko T, Jaakkola U, Raitakari OT, Kallio J (2011) Inflammatory effects of blood leukocytes: association with vascular function in neuropeptide Y proline 7-genotyped type 2 diabetes patients. Diab Vasc Dis Res.
http://www.ncbi.nlm.nih.gov/pubmed/21746772

Larsen K, Cheng C, Tempel D, Parker S, Yazdani S, den Dekker WK, . . . Duckers HJ (2011) Capture of circulatory endothelial progenitor cells and accelerated re-endothelialization of a bio-engineered stent in human ex vivo shunt and rabbit denudation model. Eur Heart J.
http://www.ncbi.nlm.nih.gov/pubmed/21733913

Lee RD, Barcel DA, Williams JC, Wang JG, Boles JC, Manly DA, . . . Mackman N (2011) Pre-analytical and analytical variables affecting the measurement of plasma-derived microparticle tissue factor activity. Thromb Res.
http://www.ncbi.nlm.nih.gov/pubmed/21737126

Lippi G, Franchini M, Targher G (2011) Arterial thrombus formation in cardiovascular disease. Nat Rev Cardiol.
http://www.ncbi.nlm.nih.gov/pubmed/21727917

Patanwala AE, Acquisto NM, Erstad BL (2011) Prothrombin Complex Concentrate for Critical Bleeding (July/August). Ann Pharmacother.
http://www.ncbi.nlm.nih.gov/pubmed/21730276

Pucci A, Formato L, Muscio M, Brscic E, Pizzimenti S, Ferroni F, . . . Spinnler MT (2011) PPARgamma in coronary atherosclerosis: In vivo expression pattern and correlations with hyperlipidemic status and statin treatment. Atherosclerosis.
http://www.ncbi.nlm.nih.gov/pubmed/21726861

Rama-Maceiras P, Ingelmo-Ingelmo I, Fabregas-Julia N, Hernandez-Palazon J (2011) [The role of recombinant activated factor VII in neuro- surgical and neurocritical patients.]. Neurocirugia (Astur) 22:209-223.
http://www.ncbi.nlm.nih.gov/pubmed/21743942

Schmid P, Mordasini A, Luginbuhl M, Regli B, Kohler HP, Zimmermann H, . . . Alberio L (2011) Low-dose recombinant factor VIIa for massive bleeding: A single centre observational cohort study with 73 patients. Swiss Med Wkly 141:w13213.
http://www.ncbi.nlm.nih.gov/pubmed/21735365

Sidelmann JJ, Skouby SO, Kluft C, Winkler U, Vitzthum F, Schwarz H, . . . Jespersen J (2011) Plasma factor VII-activating protease is increased by oral contraceptives and induces factor VII activation in-vivo. Thromb Res.
http://www.ncbi.nlm.nih.gov/pubmed/21737124

Whitehead KA, Sahay G, Li GZ, Love KT, Alabi CA, Ma M, . . . Anderson DG (2011) Synergistic Silencing: Combinations of Lipid-like Materials for Efficacious siRNA Delivery. Mol Ther.
http://www.ncbi.nlm.nih.gov/pubmed/21750531
__________________________________________________________
ABOUT TRIGGER
TRIGGER is edited by Jim Morrissey and Pierre Neuenschwander, with editorial assistance by Genie Morrissey. It includes Abstracts of Papers in Press, Meeting Announcements, Positions Sought/Available,or any other pertinent item that subscribers may want to share with their colleagues. To submit an item for publication in Trigger, e-mail us. To request or cancel a subscription,or for more information about TRIGGER or the biology of tissue factor and factor VII, visit our web site. You can also contact us by mail: J.H. Morrissey, University of Illinois College of Medicine, 417 Med Sci Bldg MC-714, 506 S. Mathews Ave., Urbana, IL 61801, USA.

DISCLAIMER: TRIGGER is provided "as is" for information purposes only and without warranty of any kind, express or implied. Users shall assume the entire risk as to the accuracy and usefulness of information in TRIGGER. Opinions expressed here are not necessarily those of the editors or their employers. You may share TRIGGER with your scientific colleagues but you are not permitted to use it or its contents for commercial purposes.
__________________________________________________________

Vol. 17, No. 13

noreply@blogger.com (Pierre) — Tue, 05 Jul 2011 19:41:00 +0000

TRIGGER
The Twice-Monthly Electronic Newsletter on the Biology of Tissue Factor, Factor VII and TFPI
Vol. 17, No. 13 July 5, 2011
(The next issue will be on July 15, 2011)
__________________________________________________________
TRIGGER is also available by RSS Feed:
http://feeds.feedburner.com/blogspot/glro
and BLOG:
http://trigger-tf7.blogspot.com/
__________________________________________________________
PAPERS IN PRESS
None submitted for this issue.
__________________________________________________________
RECENT PUBLICATIONS ON TISSUE FACTOR, FACTOR VII, AND TFPI
Papers are culled from NLM MedLine (PubMed). Titles in square brackets indicate that the paper was not published in English. References that lack volume or page numbers are typically electronic pre-publications (E-pubs) ahead of the print publication; if so, the final citation with volume and page numbers may or may not appear in a future issue of Trigger.
THE FOLLOWING LINK WILL TAKE YOU TO THE ENTIRE LIST OF THIS ISSUE'S PUBLICATIONS IN A PUBMED "COLLECTION":
http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/1X7DvXj4huqJh61LhqsJ9Vf/

Ben-Hadj-Khalifa S, Hezard N, Almawi WY, Lakbakbi S, Mace C, Cornillet-Lefebvre P, . . . Nguyen P (2011) IL-10 modulates fondaparinux inhibition of monocyte-induced thrombin generation. J Thromb Thrombolysis.
http://www.ncbi.nlm.nih.gov/pubmed/21725623

Brophy DF, Martin EJ, Barrett JC, Nolte ME, Kuhn JG, Hedner U, Ezban M (2011) Overcoming delayed in-vitro response to rFVIIa: effects of rFVIIa and rFVIIa analogue (vatreptacog alfa) concentration escalation in whole blood assays. Blood Coagul Fibrinolysis.
http://www.ncbi.nlm.nih.gov/pubmed/21681082

Carvalhal AV, Santos SS, Carrondo MJ (2011) Extracellular purine and pyrimidine catabolism in cell culture. Biotechnol Prog.
http://www.ncbi.nlm.nih.gov/pubmed/21695809

Cocco E, Varughese J, Buza N, Bellone S, Glasgow M, Bellone M, . . . Santin AD (2011) Expression of Tissue factor in Adenocarcinoma and Squamous Cell Carcinoma of the Uterine Cervix: Implications for immunotherapy with hI-con1, a factor VII-IgGFc chimeric protein targeting tissue factor. BMC Cancer 11:263.
http://www.ncbi.nlm.nih.gov/pubmed/21693061

Cocco E, Varughese J, Buza N, Bellone S, Lin KY, Bellone M, . . . Santin AD (2011) Tissue factor expression in ovarian cancer: implications for immunotherapy with hI-con1, a factor VII-IgGF(c) chimeric protein targeting tissue factor. Clin Exp Metastasis.
http://www.ncbi.nlm.nih.gov/pubmed/21725665

De Rop C, Stadler M, Buchholz S, Eisert R, Ganser A, Trummer A (2011) Evaluation of Tissue Factor Bearing Microparticles as Biomarkers in Allogeneic Stem-Cell Transplantation. Transplantation.
http://www.ncbi.nlm.nih.gov/pubmed/21681142

Girolami A, Bertozzi I, Rigoni I, Muzzolon R, Vettore S (2011) Congenital FVII deficiency and thrombotic events after replacement therapy. J Thromb Thrombolysis.
http://www.ncbi.nlm.nih.gov/pubmed/21681394

Girolami A, de Marinis GB, Bonamigo E, Vettore S (2011) Similarities and Discrepancies in Homozygous Factor VII Defects due to Mutations in the Region of Residues Met298 to Cys310 (Exon 8) in the Catalytic Domain of Factor VII. Lab Hematol 17:17-21.
http://www.ncbi.nlm.nih.gov/pubmed/21705315

Hay JW, Zhou ZY (2011) Systematic literature review of economics analysis on treatment of mild-to-moderate bleeds with aPCC versus rFVIIa. J Med Econ.
http://www.ncbi.nlm.nih.gov/pubmed/21699366

Houghton-Trivino N, Martin K, Giaya K, Rodriguez JA, Bosch I, Castellanos JE (2010) [Comparison of the transcriptional profiles of patients with dengue fever and dengue hemorrhagic fever reveals differences in the immune response and clues in immunopathogenesis.]. Biomedica 30:587-597.
http://www.ncbi.nlm.nih.gov/pubmed/21713363

Kalina M, Tinkoff G, Fulda G (2011) Massive postpartum hemorrhage: recombinant factor VIIa use is safe but not effective. Del Med J 83:109-113.
http://www.ncbi.nlm.nih.gov/pubmed/21675158

Khorana AA (2011) Risk Assessment and Prophylaxis for VTE in Cancer Patients. J Natl Compr Canc Netw 9:789-797.
http://www.ncbi.nlm.nih.gov/pubmed/21715725

Leighton BL, Wall MH, Lockhart EM, Phillips LE, Zatta AJ (2011) Use of Recombinant Factor VIIa in Patients with Amniotic Fluid Embolism: A Systematic Review of Case Reports. Anesthesiology.
http://www.ncbi.nlm.nih.gov/pubmed/21720243

Li P, Yang Y, Liu M (2011) Xuezhikang, extract of red yeast rice, inhibited Tissue Factor and Hypercoagulable state through suppressing NADPH oxidase and ERK activation. J Cardiovasc Pharmacol.
http://www.ncbi.nlm.nih.gov/pubmed/21697731

Lijnen HR, Van Hul M, Hemmeryckx B (2011) Caloric restriction improves coagulation and inflammation profile in obese mice. Thromb Res.
http://www.ncbi.nlm.nih.gov/pubmed/21689844

Luo D, Szaba FM, Kummer LW, Plow EF, Mackman N, Gailani D, Smiley ST (2011) Protective Roles for Fibrin, Tissue Factor, Plasminogen Activator Inhibitor-1, and Thrombin Activatable Fibrinolysis Inhibitor, but Not Factor XI, during Defense against the Gram-Negative Bacterium Yersinia enterocolitica. J Immunol.
http://www.ncbi.nlm.nih.gov/pubmed/21724997

Matejovic M, Chvojka J, Sykora R, Krouzecky A, Radej J, Parizkova R, . . . Cerny V (2011) A 24-h Work Shift in Intensive Care Personnel: Biological Pathways between Work Stress and Ill Health. J Int Med Res 39:629-636.
http://www.ncbi.nlm.nih.gov/pubmed/21672368

Morrissey JH (2011) Low-carb tissue factor? J Thromb Haemost.
http://www.ncbi.nlm.nih.gov/pubmed/21679295

Noto D, Cefalu AB, Barbagallo CM, Falletta A, Ganci A, Sapienza M, . . . Averna MR (2011) Prediction of incident type 2 diabetes mellitus based on a twenty-year follow-up of the Ventimiglia heart study. Acta Diabetol.
http://www.ncbi.nlm.nih.gov/pubmed/21698484

Oswanski MF, Shaik I, Nazzal M, Calkins K, Stombaugh H, Lowe S (2011) Activated Recombinant Factor VIIa and Uncontrolled Gastrointestinal Bleeding. Am Surg 77:59-61.
http://www.ncbi.nlm.nih.gov/pubmed/21679534

Parunov LA, Fadeeva OA, Balandina AN, Soshitova NP, Kopylov KG, Kumskova MA, . . . Panteleev MA (2011) Improvement of spatial fibrin formation by the anti-TFPI aptamer BAX499: changing clot size by targeting extrinsic pathway initiation. J Thromb Haemost.
http://www.ncbi.nlm.nih.gov/pubmed/21696535

Phillippe M, Diamond AK, Sweet LM, Oppenheimer KH, Bradley DF (2011) Expression of Coagulation-Related Protein Genes During LPS-Induced Preterm Delivery in the Pregnant Mouse. Reprod Sci.
http://www.ncbi.nlm.nih.gov/pubmed/21693778

Picarelli A, Di Tola M, Sabbatella L, Mercuri V, Pietrobono D, Bassotti G, . . . Gargiulo P (2011) Type 1 diabetes mellitus and celiac disease: endothelial dysfunction. Acta Diabetol.
http://www.ncbi.nlm.nih.gov/pubmed/21691748

Queiroz KC, Van 't Veer C, Van Den Berg Y, Duitman J, Versteeg HH, Aberson HL, . . . Spek CA (2011) Tissue factor-dependent chemokine production aggravates experimental colitis. Mol Med.
http://www.ncbi.nlm.nih.gov/pubmed/21717035

Quinn TJ, Gallacher J, Deary IJ, Lowe GD, Fenton C, Stott DJ (2011) Association between circulating haemostatic measures and dementia or cognitive impairment - systematic review and meta-analyses. J Thromb Haemost.
http://www.ncbi.nlm.nih.gov/pubmed/21676170

Semeraro F, Ammollo CT, Morrissey JH, Dale GL, Friese P, Esmon NL, Esmon CT (2011) Extracellular histones promote thrombin generation through platelet-dependent mechanisms: involvement of platelet TLR2 and 4. Blood.
http://www.ncbi.nlm.nih.gov/pubmed/21673343

Spiezia L, Campello E, Gentilomo C, Gavasso S, Woodhams B, Laverda AM, Simioni P (2011) Factor VIIa-antithrombin complexes in children with ischemic stroke. Thromb Res.
http://www.ncbi.nlm.nih.gov/pubmed/21708400

Tavoosi N, Davis-Harrison RL, Pogorelov TV, Ohkubo YZ, Arcario MJ, Clay MC, . . . Morrissey JH (2011) Molecular determinants of phospholipid synergy in blood clotting. J Biol Chem 286:23247-23253.
http://www.ncbi.nlm.nih.gov/pubmed/21561861

Taylor KC, Lange LA, Zabaneh D, Lange E, Keating BJ, Tang W, . . . Reiner AP (2011) A gene-centric association scan for Coagulation Factor VII levels in European and African Americans: the Candidate Gene Association Resource (CARe) Consortium. Hum Mol Genet.
http://www.ncbi.nlm.nih.gov/pubmed/21676895

Tran HT, Tjonnfjord GE, Paus A, Holme PA (2011) rFVIIa administered by continuous infusion during surgery in patients with severe congenital FVII deficiency. Haemophilia.
http://www.ncbi.nlm.nih.gov/pubmed/21707871

Tsimerman G, Roguin A, Bachar A, Melamed E, Brenner B, Aharon A (2011) Involvement of microparticles in diabetic vascular complications. Thromb Haemost 106.
http://www.ncbi.nlm.nih.gov/pubmed/21713319

Undas A, Slowik A, Gissel M, Mann KG, Butenas S (2011) Active tissue factor and activated factor XI in patients with acute ischemic cerebrovascular events. Eur J Clin Invest.
http://www.ncbi.nlm.nih.gov/pubmed/21707613

Wang R, Zhang SF, Ma YT, Chen D, Ma J, Zhou YM, Wen BZ (2011) [Expression of tissue factor in monocytes and plasma during acute phase and recovery stage of patients with myocardial infarction.]. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 23:372-373.
http://www.ncbi.nlm.nih.gov/pubmed/21672391

Yu X, Zheng L, Xiong SL, Cai Z, Wang Q (2011) [Effect of simulated microgravity on human monocytic cell proliferation and tissue factor mRNA expression.]. Nan Fang Yi Ke Da Xue Xue Bao 31:1020-1022.
http://www.ncbi.nlm.nih.gov/pubmed/21690060
__________________________________________________________
ABOUT TRIGGER
TRIGGER is edited by Jim Morrissey and Pierre Neuenschwander, with editorial assistance by Genie Morrissey. It includes Abstracts of Papers in Press, Meeting Announcements, Positions Sought/Available,or any other pertinent item that subscribers may want to share with their colleagues. To submit an item for publication in Trigger, e-mail us. To request or cancel a subscription,or for more information about TRIGGER or the biology of tissue factor and factor VII, visit our web site. You can also contact us by mail: J.H. Morrissey, University of Illinois College of Medicine, 417 Med Sci Bldg MC-714, 506 S. Mathews Ave., Urbana, IL 61801, USA.

DISCLAIMER: TRIGGER is provided "as is" for information purposes only and without warranty of any kind, express or implied. Users shall assume the entire risk as to the accuracy and usefulness of information in TRIGGER. Opinions expressed here are not necessarily those of the editors or their employers. You may share TRIGGER with your scientific colleagues but you are not permitted to use it or its contents for commercial purposes.
__________________________________________________________

Vol. 17, No. 12

noreply@blogger.com (Pierre) — Wed, 15 Jun 2011 16:21:00 +0000

TRIGGER
The Twice-Monthly Electronic Newsletter on the Biology of Tissue Factor, Factor VII and TFPI
Vol. 17, No. 12 June 15, 2011
(The next issue will be on July 5, 2011)
__________________________________________________________
TRIGGER is also available by RSS Feed:
http://feeds.feedburner.com/blogspot/glro
and BLOG:
http://trigger-tf7.blogspot.com/
__________________________________________________________
PAPERS IN PRESS
None submitted for this issue.
__________________________________________________________
RECENT PUBLICATIONS ON TISSUE FACTOR, FACTOR VII, AND TFPI
Papers are culled from NLM MedLine (PubMed). Titles in square brackets indicate that the paper was not published in English. References that lack volume or page numbers are typically electronic pre-publications (E-pubs) ahead of the print publication; if so, the final citation with volume and page numbers may or may not appear in a future issue of Trigger.
THE FOLLOWING LINK WILL TAKE YOU TO THE ENTIRE LIST OF THIS ISSUE'S PUBLICATIONS IN A PUBMED "COLLECTION":
http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/1X3fkHdxzD_GHbjF9i93nRh/

Abdel-Bakky MS, Hammad MA, Walker LA, Ashfaq MK (2011) Tissue factor dependent liver injury causes release of retinoid receptors (RXR-alpha and RAR-alpha) as lipid droplets. Biochem Biophys Res Commun.
http://www.ncbi.nlm.nih.gov/pubmed/21658367

Ando K, Ishibashi T, Ohkawara H, Inoue N, Sugimoto K, Uekita H, . . . Takeishi Y (2011) Crucial Role of Membrane Type 1 Matrix Metalloproteinase (MT1- MMP) in RhoA/Rac1-Dependent Signaling Pathways in Thrombin- Stimulated Endothelial Cells. J Atheroscler Thromb.
http://www.ncbi.nlm.nih.gov/pubmed/21628952

Baranovic S, Lubina IZ, Nikolic T, Maldini B (2011) Successful use of recombinant factor Viia in traumatic liver injury--a case report. Coll Antropol 35:193-196.
http://www.ncbi.nlm.nih.gov/pubmed/21661370

Ding L, Ma W, Littmann T, Camp R, Shen J (2011) The P2Y2 nucleotide receptor mediates tissue factor expression in human coronary artery endothelial cells. J Biol Chem.
http://www.ncbi.nlm.nih.gov/pubmed/21652710

Dong X, Song LP, Zhu DW, Zhang HL, Liu LX, Leng XG (2011) Impact of the tissue factor pathway inhibitor gene on apoptosis in human vascular smooth muscle cells. Genet Mol Biol 34:25-30.
http://www.ncbi.nlm.nih.gov/pubmed/21637538

Furlan-Freguia C, Marchese P, Gruber A, Ruggeri ZM, Ruf W (2011) P2X7 receptor signaling contributes to tissue factor-dependent thrombosis in mice. J Clin Invest.
http://www.ncbi.nlm.nih.gov/pubmed/21670495

Hay JW, Zhou ZY (2011) Economical comparison of APCC vs. rFVIIa for mild-to-moderate bleeding episodes in haemophilia patients with inhibitors. Haemophilia.
http://www.ncbi.nlm.nih.gov/pubmed/21649802

Hoshi A, Matsumoto A, Chung J, Isozumi Y, Koyama T (2011) Activation of coagulation by a thalidomide-based regimen. Blood Coagul Fibrinolysis.
http://www.ncbi.nlm.nih.gov/pubmed/21670663

Kanse SM, Etscheid M (2011) Factor VII activating protease. Single nucleotide polymorphisms light the way. Hamostaseologie 31.
http://www.ncbi.nlm.nih.gov/pubmed/21655671

Knudsen T, Kristensen AT, Nichols TC, Agerso H, Jensen AL, Kjalke M, . . . Tranholm M (2011) Pharmacokinetics, pharmacodynamics and safety of recombinant canine FVIIa in a study dosing one haemophilia A and one haemostatically normal dog. Haemophilia.
http://www.ncbi.nlm.nih.gov/pubmed/21645178

Kristensen M, Bugel S (2011) A diet rich in oat bran improves blood lipids and hemostatic factors, and reduces apparent energy digestibility in young healthy volunteers. Eur J Clin Nutr.
http://www.ncbi.nlm.nih.gov/pubmed/21654701

Li J, Liu Y, Yin W, Zhang C, Huang J, Liao C, . . . Xiao P (2011) Alterations of the preoperative coagulation profile in patients with acute appendicitis. Clin Chem Lab Med.
http://www.ncbi.nlm.nih.gov/pubmed/21663567

Lopez-Vilchez I, Hedner U, Altisent C, Diaz-Ricart M, Escolar G, Galan AM (2011) Redistribution and Hemostatic Action of Recombinant Activated Factor VII Associated with Platelets. Am J Pathol 178:2938-2948.
http://www.ncbi.nlm.nih.gov/pubmed/21641410

Ma X, Ye B, Gao F, Liang Q, Dong Q, Liu Y, . . . Nan YS (2011) Tissue Factor knockdown in Porcine Islets: An Effective Approach to Suppressing the Instant Blood-Mediated Inflammatory Reaction. Cell Transplant.
http://www.ncbi.nlm.nih.gov/pubmed/21669037

Mahale R, Rathi P, Ginegiri C, Aggarwal R (2010) Factor VII Deficiency: A Rare Case Report. Indian J Hematol Blood Transfus 26:68-69.
http://www.ncbi.nlm.nih.gov/pubmed/21629640

McLintock C, James AH (2011) Obstetric Hemorrhage. J Thromb Haemost.
http://www.ncbi.nlm.nih.gov/pubmed/21668737

Mitrophanov AY, Reifman J (2011) Kinetic modeling sheds light on the mode of action of recombinant factor VIIa on thrombin generation. Thromb Res.
http://www.ncbi.nlm.nih.gov/pubmed/21641634

Sanchez JF, Le L, Arroliga AC (2011) How Tifacogin Could Not Captivate Severe Community-acquired Pneumonia. Am J Respir Crit Care Med 183:1449-1450.
http://www.ncbi.nlm.nih.gov/pubmed/21642255

Sequeira A, Santos RF, Bodnar T (2011) Blood coagulation dynamics: mathematical modeling and stability results. Math Biosci Eng 8:425-443.
http://www.ncbi.nlm.nih.gov/pubmed/21631138

Stephan S, Schwarz H, Haude-Barten A, Sidelmann JJ, Fischer B, Althaus H, . . . Vitzthum F (2011) Direct chromogenic substrate immuno-capture activity assay for testing of factor VII-activating protease. Clin Chem Lab Med.
http://www.ncbi.nlm.nih.gov/pubmed/21663569

Storgaard M, Henriksen ST, Zaragoza F, Peschke B, Tanner D (2011) Design, synthesis and biological activity of novel peptidyl benzyl ketone FVIIa inhibitors. Bioorg Med Chem Lett 21:3918-3922.
http://www.ncbi.nlm.nih.gov/pubmed/21641796

Uszynski M, Zekanowska E, Uszynski W, Kuczynski J, Zylinski A (2011) Microparticles (MPs), tissue factor (TF) and tissue factor inhibitor (TFPI) in cord blood plasma. A preliminary study and literature survey of procoagulant properties of MPs. Eur J Obstet Gynecol Reprod Biol.
http://www.ncbi.nlm.nih.gov/pubmed/21664032
__________________________________________________________
ABOUT TRIGGER
TRIGGER is edited by Jim Morrissey and Pierre Neuenschwander, with editorial assistance by Genie Morrissey. It includes Abstracts of Papers in Press, Meeting Announcements, Positions Sought/Available,or any other pertinent item that subscribers may want to share with their colleagues. To submit an item for publication in Trigger, e-mail us. To request or cancel a subscription,or for more information about TRIGGER or the biology of tissue factor and factor VII, visit our web site. You can also contact us by mail: J.H. Morrissey, University of Illinois College of Medicine, 417 Med Sci Bldg MC-714, 506 S. Mathews Ave., Urbana, IL 61801, USA.

DISCLAIMER: TRIGGER is provided "as is" for information purposes only and without warranty of any kind, express or implied. Users shall assume the entire risk as to the accuracy and usefulness of information in TRIGGER. Opinions expressed here are not necessarily those of the editors or their employers. You may share TRIGGER with your scientific colleagues but you are not permitted to use it or its contents for commercial purposes.
__________________________________________________________

Vol. 17, No. 11

noreply@blogger.com (Pierre) — Wed, 01 Jun 2011 21:52:00 +0000

TRIGGER
The Twice-Monthly Electronic Newsletter on the Biology of Tissue Factor, Factor VII and TFPI
Vol. 17, No. 11 June 1, 2011
(The next issue will be on June 15, 2011)
__________________________________________________________
TRIGGER is also available by RSS Feed:
http://feeds.feedburner.com/blogspot/glro
and BLOG:
http://trigger-tf7.blogspot.com/
__________________________________________________________
PAPERS IN PRESS
None submitted for this issue.
__________________________________________________________
RECENT PUBLICATIONS ON TISSUE FACTOR, FACTOR VII, AND TFPI
Papers are culled from NLM MedLine (PubMed). Titles in square brackets indicate that the paper was not published in English. References that lack volume or page numbers are typically electronic pre-publications (E-pubs) ahead of the print publication; if so, the final citation with volume and page numbers may or may not appear in a future issue of Trigger.
THE FOLLOWING LINK WILL TAKE YOU TO THE ENTIRE LIST OF THIS ISSUE'S PUBLICATIONS IN A PUBMED "COLLECTION":
http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/1VIYzi36diIQjGMaN3yDCRU/

Abe R, Yamashita N, Rochier A, Nixon A, Madri JA, Sumpio BE (2011) Varying Effects of Hemodynamic Forces on Tissue Factor RNA Expression in Human Endothelial Cells. J Surg Res.
http://www.ncbi.nlm.nih.gov/pubmed/21592524

Banfi C, Brioschi M, Lento S, Pirillo A, Galli S, Cosentino S, . . . Mussoni L (2011) Statins prevent tissue factor induction by protease-activated receptors 1 and 2 in human umbilical vein endothelial cells in vitro. J Thromb Haemost.
http://www.ncbi.nlm.nih.gov/pubmed/21605334

Ben-Hadj-Khalifa S, Hezard N, Almawi WY, Remy MG, Florent B, Mahjoub T, Nguyen P (2011) Differential coagulation inhibitory effect of fondaparinux, enoxaparin and unfractionated heparin in cell models of thrombin generation. Blood Coagul Fibrinolysis.
http://www.ncbi.nlm.nih.gov/pubmed/21577096

Butros L, Boayue K, Mathew P (2011) Current difficulties and recent advances in bypass therapy for the management of hemophilia with inhibitors: a new and practical formulation of recombinant factor VIIa. Drug Des Devel Ther 5:275-282.
http://www.ncbi.nlm.nih.gov/pubmed/21625417

Chapman AJ, Blount AL, Davis AT, Hooker RL (2011) Recombinant factor VIIa (NovoSeven RT) use in high risk cardiac surgery. Eur J Cardiothorac Surg.
http://www.ncbi.nlm.nih.gov/pubmed/21601468

Darlington DN, Delgado AV, Kheirabadi BS, Fedyk CG, Scherer MR, Pusateri AE, . . . Dubick MA (2011) Effect of Hemodilution on Coagulation and Recombinant Factor VIIa Efficacy in Human Blood In Vitro. J Trauma.
http://www.ncbi.nlm.nih.gov/pubmed/21610535

Davidson SJ, Woodhams B (2011) Factor VIIa-Antithrombin complexes during cardiac surgery using cardiopulmonary bypass. Int J Lab Hematol.
http://www.ncbi.nlm.nih.gov/pubmed/21569219

Dutton RP, Parr M, Tortella BJ, Champion HR, Bernard GR, Boffard K, . . . Hauser CJ (2011) Recombinant Activated Factor VII Safety in Trauma Patients: Results From the CONTROL Trial. J Trauma.
http://www.ncbi.nlm.nih.gov/pubmed/21610529

Egorina EM, Sovershaev MA, Hansen JB (2011) The role of tissue factor in systemic inflammatory response syndrome. Blood Coagul Fibrinolysis.
http://www.ncbi.nlm.nih.gov/pubmed/21597365

Figueras J, Monasterio J, Domingo E, Meneses B, Nieto E, Cortadellas J, Garcia-Dorado D (2011) Prothrombotic profile in patients with vasospastic or non vasospastic angina and non significant coronary stenosis. Thromb J 9:10.
http://www.ncbi.nlm.nih.gov/pubmed/21619612

Fu WJ, Zheng L, Wang Q, Deng RT, Ye CQ, Wang SB, . . . Tang HH (2011) [Urinary level of tissue factor and its procoagulant activity in patients with type 2 diabetes.]. Nan Fang Yi Ke Da Xue Xue Bao 31:878-881.
http://www.ncbi.nlm.nih.gov/pubmed/21602148

Guo D, Zhou H, Wu Y, Zhou F, Xu G, Wen H, Zhang X (2011) Involvement of ERK1/2/NF-kappaB signal transduction pathway in TF/FVIIa/PAR2-induced proliferation and migration of colon cancer cell SW620. Tumour Biol.
http://www.ncbi.nlm.nih.gov/pubmed/21625939

Hengel LG, Versteeg HH (2011) Tissue Factor signaling: a multi-faceted function in biological processes. Front Biosci (Schol Ed) 3:1500-1510.
http://www.ncbi.nlm.nih.gov/pubmed/21622285

Holy EW, Forestier M, Richter EK, Akhmedov A, Leiber F, Camici GG, . . . Tanner FC (2011) Dietary {alpha}-Linolenic Acid Inhibits Arterial Thrombus Formation, Tissue Factor Expression, and Platelet Activation. Arterioscler Thromb Vasc Biol.
http://www.ncbi.nlm.nih.gov/pubmed/21571683

Khan OA, Blann AD, Payne MJ, Middleton MR, Protheroe AS, Talbot DC, . . . Harris AL (2011) Continuous low-dose cyclophosphamide and methotrexate combined with celecoxib for patients with advanced cancer. Br J Cancer.
http://www.ncbi.nlm.nih.gov/pubmed/21587257

Knudsen T, Olsen OH, Petersen LC (2011) Tissue factor and factor VIIa cross-species compatibility. Front Biosci 17:3196-3215.
http://www.ncbi.nlm.nih.gov/pubmed/21622229

Lee BJ, Kim JH, Woo SH, Kim DH, Yu YS (2011) Tissue factor is involved in retinoblastoma cell proliferation via both the Akt and extracellular signal-regulated kinase pathways. Oncol Rep.
http://www.ncbi.nlm.nih.gov/pubmed/21617868

Liang HP, Brophy TM, Hogg PJ (2011) Redox properties of the Tissue Factor Cys186-Cys209 disulfide bond. Biochem J.
http://www.ncbi.nlm.nih.gov/pubmed/21595632

Lippi G, Franchini M, Montagnana M, Favaloro EJ (2011) Inherited disorders of blood coagulation. Ann Med.
http://www.ncbi.nlm.nih.gov/pubmed/21585250

Martinet W, Schrijvers DM, De Meyer GR (2011) Necrotic cell death in atherosclerosis. Basic Res Cardiol.
http://www.ncbi.nlm.nih.gov/pubmed/21611880

Mast AE (2011) Alternatively spliced tissue factor pathway inhibitor: Functional Implications. Front Biosci (Schol Ed) 3:1457-1462.
http://www.ncbi.nlm.nih.gov/pubmed/21622281

Mazzolai L, Bouzourene K, Hayoz D, Dignat-George F, Liu JW, Bounameaux H, . . . Kruithof EK (2011) Characterization of Human Late Outgrowth Endothelial Progenitor-Derived Cells under Various Flow Conditions. J Vasc Res 48:443-451.
http://www.ncbi.nlm.nih.gov/pubmed/21625177

McCracken N, Lahu G, Bethke TD (2011) Lack of pharmacokinetic and pharmacodynamic interactions of roflumilast with (R, S)-warfarin in healthy adult subjects. Int J Clin Pharmacol Ther 49:388-396.
http://www.ncbi.nlm.nih.gov/pubmed/21612746

Mobarrez F, He S, Broijersen A, Wiklund B, Antovic A, Antovic J, . . . Wallen H (2011) Atorvastatin reduces thrombin generation and expression of tissue factor, P-selectin and GPIIIa on platelet-derived microparticles in patients with peripheral arterial occlusive disease. Thromb Haemost 106.
http://www.ncbi.nlm.nih.gov/pubmed/21614411

Moss J, Rosholm A, Lauren A (2011) Safety and pharmacokinetics of a glycoPEGylated recombinant activated FVII derivative: a randomized first human dose trial in healthy subjects. J Thromb Haemost.
http://www.ncbi.nlm.nih.gov/pubmed/21575130

Nakatomi Y, Tsuji M, Nakashima T, Gokudan S, Miyazaki H, Tomokiyo K, . . . Mogi M (2011) Pharmacokinetics, distribution, and excretion of (125)I-labeled human plasma-derived-FVIIa and -FX with MC710 (FVIIa/FX mixture) in rats. Thromb Res.
http://www.ncbi.nlm.nih.gov/pubmed/21621824

Pan J, Shi H, Luo X, Ma D, Liang W, Zhang J, . . . Li J (2011) [Construction of replication-deficient recombinant adenovirus vector with hTFPI-2 gene by AdMax system and expression in U937 monocytes in vitro]. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 28:326-331.
http://www.ncbi.nlm.nih.gov/pubmed/21604496

Persson E, Olsen OH (2011) Allosteric activation of coagulation factor VIIa. Front Biosci 17:3156-3163.
http://www.ncbi.nlm.nih.gov/pubmed/21622226

Ponschab M, Landoni G, Biondi-Zoccai G, Bignami E, Frati E, Nicolotti D, . . . Zangrillo A (2011) Recombinant Activated Factor VII Increases Stroke in Cardiac Surgery: A Meta-analysis. J Cardiothorac Vasc Anesth.
http://www.ncbi.nlm.nih.gov/pubmed/21596585

Saito Y, Hashimoto Y, Kuroda JI, Yasunaga M, Koga Y, Takahashi A, Matsumura Y (2011) The inhibition of pancreatic cancer invasion-metastasis cascade in both cellular signal and blood coagulation cascade of tissue factor by its neutralisation antibody. Eur J Cancer.
http://www.ncbi.nlm.nih.gov/pubmed/21621407

Srinivasan R, Bogdanov VY (2011) Alternatively spliced Tissue Factor: discovery, insights, clinical implications. Front Biosci 17:3061-3071.
http://www.ncbi.nlm.nih.gov/pubmed/21622222

Sugimura H, Tao H, Suzuki M, Mori H, Tsuboi M, Matsuura S, . . . Matsuda T (2011) Genetic susceptibility to lung cancer. Front Biosci (Schol Ed) 3:1463-1477.
http://www.ncbi.nlm.nih.gov/pubmed/21622282

Undas A, Jankowski M, Kaczmarek P, Sladek K, Brummel-Ziedins K (2011) Thrombin generation in chronic obstructive pulmonary disease: Dependence on plasma factor composition. Thromb Res.
http://www.ncbi.nlm.nih.gov/pubmed/21624643

Xu C, Gui Q, Chen W, Wu L, Sun W, Zhang N, . . . Fu X (2011) Small interference RNA targeting tissue factor inhibits human lung adenocarcinoma growth in vitro and in vivo. J Exp Clin Cancer Res 30:63.
http://www.ncbi.nlm.nih.gov/pubmed/21619686

Yamamichi S, Fujiwara Y, Kikuchi T, Nishitani M, Matsushita Y, Hasumi K (2011) Extracellular histone induces plasma hyaluronan-binding protein (factor VII activating protease) activation in vivo. Biochem Biophys Res Commun.
http://www.ncbi.nlm.nih.gov/pubmed/21600885

Zhang J, Yang S, Xie Y, Chen X, Zhao Y, He D, Li J (2011) Detection of methylated tissue factor pathway inhibitor 2 and human long DNA in fecal samples of patients with colorectal cancer in China. Cancer Epidemiol.
http://www.ncbi.nlm.nih.gov/pubmed/21621497
__________________________________________________________
ABOUT TRIGGER
TRIGGER is edited by Jim Morrissey and Pierre Neuenschwander, with editorial assistance by Genie Morrissey. It includes Abstracts of Papers in Press, Meeting Announcements, Positions Sought/Available,or any other pertinent item that subscribers may want to share with their colleagues. To submit an item for publication in Trigger, e-mail us. To request or cancel a subscription,or for more information about TRIGGER or the biology of tissue factor and factor VII, visit our web site. You can also contact us by mail: J.H. Morrissey, University of Illinois College of Medicine, 417 Med Sci Bldg MC-714, 506 S. Mathews Ave., Urbana, IL 61801, USA.

DISCLAIMER: TRIGGER is provided "as is" for information purposes only and without warranty of any kind, express or implied. Users shall assume the entire risk as to the accuracy and usefulness of information in TRIGGER. Opinions expressed here are not necessarily those of the editors or their employers. You may share TRIGGER with your scientific colleagues but you are not permitted to use it or its contents for commercial purposes.
__________________________________________________________

Vol.17, No.10

noreply@blogger.com (Pierre) — Thu, 19 May 2011 12:43:00 +0000

TRIGGER
The Twice-Monthly Electronic Newsletter on the Biology of Tissue Factor, Factor VII and TFPI
Vol. 17, No. 10 May 16, 2011
(The next issue will be on June 1, 2011)
__________________________________________________________
TRIGGER is also available by RSS Feed:
http://feeds.feedburner.com/blogspot/glro
and BLOG:
http://trigger-tf7.blogspot.com/
__________________________________________________________
PAPERS IN PRESS
AUTHORS: Tavoosi N, Davis-Harrison RL, Pogorelov TV, Ohkubo YZ, Arcario MJ, Clay MC, Rienstra CM, Tajkhorshid E and Morrissey JH
TITLE: Molecular determinants of phospholipid synergy in blood clotting
JOURNAL: The Journal of Biological Chemistry
ABSTRACT: Many regulatory processes in biology involve reversible association of proteins with membranes. Clotting proteins bind to phosphatidylserine on cell surfaces, but a clear picture of this
interaction has yet to emerge. We present a novel explanation for membrane binding by GLA domains of clotting proteins, supported by biochemical studies, solid-state NMR analyses and molecular dynamics simulations. The model invokes a single "phospho-L-serine-specific" interaction and multiple "phosphate-specific" interactions. In the latter, the phosphates in phospholipids interact with tightly bound Ca2+ in GLA domains. We show that phospholipids with any headgroup other than choline strongly synergize with phosphatidylserine to enhance factor X activation. We propose that phosphatidylcholine and sphingomyelin (the major external phospholipids of healthy cells) are
anticoagulant primarily because their bulky choline headgroups sterically hinder access to their phosphates. Following cell damage or activation, exposed phosphatidylserine and
phosphatidylethanolamine collaborate to bind GLA domains, by providing phospho-L-serine-specific and phosphate-specific interactions, respectively.
PREPRINT: http://www.jbc.org/content/early/2011/05/11/jbc.M111.251769
SUBMITTED BY: Jim Morrissey: jhmorris AT illinois DOT edu
__________________________________________________________
RECENT PUBLICATIONS ON TISSUE FACTOR, FACTOR VII, AND TFPI
Papers are culled from NLM MedLine (PubMed). Titles in square brackets indicate that the paper was not published in English. References that lack volume or page numbers are typically electronic pre-publications (E-pubs) ahead of the print publication; if so, the final citation with volume and page numbers may or may not appear in a future issue of Trigger.
THE FOLLOWING LINK WILL TAKE YOU TO THE ENTIRE LIST OF THIS ISSUE'S PUBLICATIONS IN A PUBMED "COLLECTION":
http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/1fsZsuNJhHORjzcAXyzPROE/

Bergrem A, Dahm AE, Jacobsen AF, Mowinckel MC, Sandvik L, Sandset PM (2011) Resistance to activated protein C is a risk factor for pregnancy-related venous thrombosis in the absence of the F5 rs6025 (factor V Leiden) polymorphism. Br J Haematol.
http://www.ncbi.nlm.nih.gov/pubmed/21564075

Ferrari L, Podda GM (2011) Off-label use of recombinant activated coagulation factor VII for bleeding may raise the risk of arterial thrombosis. Intern Emerg Med.
http://www.ncbi.nlm.nih.gov/pubmed/21541718

Gessler F, Voss V, Seifert V, Gerlach R, Kogel D (2011) Knockdown of TFPI-2 promotes migration and invasion of glioma cells. Neurosci Lett.
http://www.ncbi.nlm.nih.gov/pubmed/21530612

Gouni-Berthold I, Berthold HK (2011) Lipoprotein(a): Current Perspectives. Curr Vasc Pharmacol.
http://www.ncbi.nlm.nih.gov/pubmed/21529331

Gray LD, Hussey MA, Larson BM, Machlus KR, Campbell RA, Koch G, . . . Wolberg AS (2011) Recombinant factor VIIa analog NN1731 (V158D/E296V/M298Q-FVIIa) enhances fibrin formation, structure and stability in lipidated hemophilic plasma. Thromb Res.
http://www.ncbi.nlm.nih.gov/pubmed/21561645

Hacquard M, Durand M, Lecompte T, Boini S, Briancon S, Carteaux JP (2011) Off-label use of recombinant activated factor VII in intractable haemorrhage after cardiovascular surgery: an
observational study of practices in 23 French cardiac centres (2005-7). Eur J Cardiothorac Surg.
http://www.ncbi.nlm.nih.gov/pubmed/21550261

Jiang MH, Wang ZY, Yu ZQ, Bai X, Cao LJ, Su J, . . . Ruan CG (2011) [Genotype and phenotype analysis of congenital coagulator factor VII deficiency in four Chinese pedigrees.]. Zhonghua Xue Ye Xue Za Zhi 32:147-152.
http://www.ncbi.nlm.nih.gov/pubmed/21535950
Kambas K, Chrysanthopoulou A, Kourtzelis I, Skordala M, Mitroulis I, Rafail S, . . . Ritis K (2011) Endothelin-1 Signaling Promotes Fibrosis In Vitro in a Bronchopulmonary Dysplasia Model by Activating the Extrinsic Coagulation Cascade. J Immunol.
http://www.ncbi.nlm.nih.gov/pubmed/21531894

Kopp CW, Gremmel T, Steiner S, Seidinger D, Minar E, Maurer G, Huber K (2011) Platelet-monocyte cross talk and tissue factor expression in stable angina vs. unstable angina/non ST-elevation myocardial infarction. Platelets.
http://www.ncbi.nlm.nih.gov/pubmed/21557685

Kothari H, Rao LV, Pendurthi R (2011) Glycosylation of tissue factor is not essential for its transport or functions. J Thromb Haemost.
http://www.ncbi.nlm.nih.gov/pubmed/21535396

Layland J, Ray MJ, Siresena T, Walters DL (2011) Increased expression of monocyte tissue factor and soluble CD40 ligand at mid-term follow-up following percutaneous coronary intervention. Blood Coagul Fibrinolysis 22:349-350.
http://www.ncbi.nlm.nih.gov/pubmed/21546798

Ma Z, Zhang T, Wang R, Cheng Z, Xu H, Li W, . . . Wang X (2011) Tissue Factor-Factor VIIa Complex Induces Epithelial Ovarian Cancer Cell Invasion and Metastasis Through a Monocytes-Dependent Mechanism. Int J Gynecol Cancer 21:616-624.
http://www.ncbi.nlm.nih.gov/pubmed/21543928

Monteiro RQ (2011) Tissue factor as a target for the treatment of disseminated intravascular coagulation. Thromb Res.
http://www.ncbi.nlm.nih.gov/pubmed/21531009

Opstad TB, Pettersen AA, Bratseth V, Arnesen H, Seljeflot I (2011) The Influence of Tissue Factor and Tissue Factor Pathway Inhibitor Polymorphisms on Thrombin Generation in Stable Coronary Artery Disease. Pathophysiol Haemost Thromb.
http://www.ncbi.nlm.nih.gov/pubmed/21555871

Owens AP, 3rd, Mackman N (2011) Microparticles in hemostasis and thrombosis. Circ Res 108:1284-1297.
http://www.ncbi.nlm.nih.gov/pubmed/21566224

Shirahata A, Fukutake K, Mimaya J, Takamatsu J, Shima M, Hanabusa H, . . . Saito H (2011) Clinical pharmacological study of a plasma-derived factor VIIa and factor X mixture (MC710) in haemophilia patients with inhibitors - Phase I trial. Haemophilia.
http://www.ncbi.nlm.nih.gov/pubmed/21535327

Siboni SM, Zanon E, Sottilotta G, Consonni D, Castaman G, Mikovic D, . . . Peyvandi F (2011) Central nervous system bleeding in patients with rare bleeding disorders. Haemophilia.
http://www.ncbi.nlm.nih.gov/pubmed/21539694

Szmurlo D, Derylo L, Rys P, Wladysiuk M (2011) [Health economics of inhibitor bypassing agents in haemophilia A-activated prothrombin complex concentrate (aPCC) and recombinant activated factor VIIa (rFVIIa)]. Pol Merkur Lekarski 30:202-207.
http://www.ncbi.nlm.nih.gov/pubmed/21544998

Tiede A, Rand JH, Budde U, Ganser A, Federici AB (2011) How I Treat acquired von Willebrand syndrome. Blood.
http://www.ncbi.nlm.nih.gov/pubmed/21540459

Xing ZF, Wang XF, Dai J, Lu YL, Xu GQ, Xi XD, Wang HL (2011) [Two novel mutations in one pedigree with here-ditary Factor VII deficiency.]. Zhonghua Xue Ye Xue Za Zhi 32:158-162.
http://www.ncbi.nlm.nih.gov/pubmed/21535952

Xu GY, Zhou H, Wen HP, Guo DL, Zhou F, Chen DD, Xie HX (2011) [Activation of tumor necrosis factor receptor-associated factor 6 in anti-beta(2);GPI/beta(2);GPI-induced tissue factor expression on
THP-1 cells.]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 27:487-490.
http://www.ncbi.nlm.nih.gov/pubmed/21557901

Zheng F, Jin Y, Wang M, Niu Z, Xu P, Xie H (2011) Congenital combined deficiency of factor VII and X in a patient due to accidental diphacinone intoxication. Thromb Haemost 106.
http://www.ncbi.nlm.nih.gov/pubmed/21544315
__________________________________________________________
ABOUT TRIGGER
TRIGGER is edited by Jim Morrissey and Pierre Neuenschwander, with editorial assistance by Genie Morrissey. It includes Abstracts of Papers in Press, Meeting Announcements, Positions Sought/Available,or any other pertinent item that subscribers may want to share with their colleagues. To submit an item for publication in Trigger, e-mail us. To request or cancel a subscription,or for more information about TRIGGER or the biology of tissue factor and factor VII, visit our web site. You can also contact us by mail: J.H. Morrissey, University of Illinois College of Medicine, 417 Med Sci Bldg MC-714, 506 S. Mathews Ave., Urbana, IL 61801, USA.

DISCLAIMER: TRIGGER is provided "as is" for information purposes only and without warranty of any kind, express or implied. Users shall assume the entire risk as to the accuracy and usefulness of information in TRIGGER. Opinions expressed here are not necessarily those of the editors or their employers. You may share TRIGGER with your scientific colleagues but you are not permitted to use it or its contents for commercial purposes.
__________________________________________________________

Vol. 17, No. 9

noreply@blogger.com (Pierre) — Thu, 05 May 2011 14:41:00 +0000

TRIGGER
The Twice-Monthly Electronic Newsletter on the Biology of Tissue Factor, Factor VII and TFPI
Vol. 17, No. 9 May 2, 2011
(The next issue will be on May 16, 2011)
__________________________________________________________
TRIGGER is also available by RSS Feed:
http://feeds.feedburner.com/blogspot/glro
and BLOG:
http://trigger-tf7.blogspot.com/
__________________________________________________________
PAPERS IN PRESS
None submitted for this issue.
__________________________________________________________
RECENT PUBLICATIONS ON TISSUE FACTOR, FACTOR VII, AND TFPI
Papers are culled from NLM MedLine (PubMed). Titles in square brackets indicate that the paper was not published in English. References that lack volume or page numbers are typically electronic pre-publications (E-pubs) ahead of the print publication; if so, the final citation with volume and page numbers may or may not appear in a future issue of Trigger.
THE FOLLOWING LINK WILL TAKE YOU TO THE ENTIRE LIST OF THIS ISSUE'S PUBLICATIONS IN A PUBMED "COLLECTION":
http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/1D1ujUs8aowD0-gQBk-gEqi/

Al-Amri MS, Alrasadi K, Bayoumi R, Banerjee Y (2011) In Silico Design of Novel Anticoagulant Peptides targeting Blood Coagulation Factor VIIa. Sultan Qaboos Univ Med J 11:83-94.
http://www.ncbi.nlm.nih.gov/pubmed/21509213

Blank M, Baraam L, Eisenstein M, et al. (2011) beta(2)-Glycoprotein-I based peptide regulate endothelial-cells tissue-factor expression via negative regulation of pGSK3beta expression and reduces experimental-antiphospholipid-syndrome. J Autoimmun.
http://www.ncbi.nlm.nih.gov/pubmed/21524885

Cimmino G, D'Amico C, Vaccaro V, D'Anna M, Golino P (2011) The missing link between atherosclerosis, inflammation and thrombosis: is it tissue factor? Expert Rev Cardiovasc Ther 9:517-523.
http://www.ncbi.nlm.nih.gov/pubmed/21517734

Fang Y, Cai JY, Zhong JH, Zhong H, Wang HR, Chen FY (2011) [Expression of Alternatively Spliced Human Tissue Factor in Acute Leukemia Cells.]. Zhongguo Shi Yan Xue Ye Xue Za Zhi 19:288-292.
http://www.ncbi.nlm.nih.gov/pubmed/21518473

Konecny FA (2010) Review of cellular and molecular pathways linking thrombosis and innate immune system during sepsis. J Res Med Sci 15:348-358.
http://www.ncbi.nlm.nih.gov/pubmed/21526108

Lee CW, Park CS, Hwang I, et al. (2011) Comparison of ruptured coronary plaques in patients with unstable and stable clinical presentation. J Thromb Thrombolysis.
http://www.ncbi.nlm.nih.gov/pubmed/21505786

Lian WS, Lin H, Cheng WT, Kikuchi T, Cheng CF (2011) Granulocyte-CSF induced inflammation-associated cardiac thrombosis in iron loading mouse heart and can be attenuated by statin therapy. J Biomed Sci 18:26.
http://www.ncbi.nlm.nih.gov/pubmed/21496220

Lockwood CJ (2011) Mechanisms of Normal and Abnormal Endometrial Bleeding. Menopause 18:408-411.
http://www.ncbi.nlm.nih.gov/pubmed/21499503

Logan AC, Yank V, Stafford RS (2011) Off-Label Use of Recombinant Factor VIIa in U.S. Hospitals: Analysis of Hospital Records. Ann Intern Med 154:516-522.
http://www.ncbi.nlm.nih.gov/pubmed/21502649

Luporsi P, Chopard R, Janin S, et al. (2011) Use of recombinant factor VIIa (NovoSeven((R))) in 8 patients with ongoing life-threatening bleeding treated with fondaparinux. Acute Card Care.
http://www.ncbi.nlm.nih.gov/pubmed/21517672

Luszczak J, Undas A, Gissel M, Olszowska M, Butenas S (2011) Activated factor XI and tissue factor in aortic stenosis: links with thrombin generation. Blood Coagul Fibrinolysis.
http://www.ncbi.nlm.nih.gov/pubmed/21519234

Matafonov A, Sarilla S, Sun MF, et al. (2011) Activation of factor XI by products of prothrombin activation. Blood.
http://www.ncbi.nlm.nih.gov/pubmed/21527525

Notarnicola A, Pesce V, Scaraggi A, Maccagnano G, Vicenti G, Moretti B (2011) Total hip replacement in a patient with acquired haemophilia a: a case report and literature review. Blood Coagul Fibrinolysis.
http://www.ncbi.nlm.nih.gov/pubmed/21508830

Pou J, Rebollo A, Piera L, et al. (2011) Tissue factor pathway inhibitor 2 is induced by thrombin in human macrophages. Biochim Biophys Acta.
http://www.ncbi.nlm.nih.gov/pubmed/21515313

Rolfe S, Papadopoulos S, Cabral KP (2010) Controversies of anticoagulation reversal in life-threatening bleeds. J Pharm Pract 23:217-225.
http://www.ncbi.nlm.nih.gov/pubmed/21507817

Sarig G, Klil-Drori AJ, Chap-Marshak D, Brenner B, Drugan A (2011) Activation of coagulation in amniotic fluid during normal human pregnancy. Thromb Res.
http://www.ncbi.nlm.nih.gov/pubmed/21504838

Smith NL, Huffman JE, Strachan DP, et al. (2011) Genetic Predictors of Fibrin D-Dimer Levels in Healthy Adults. Circulation.
http://www.ncbi.nlm.nih.gov/pubmed/21502573

Steppich BA, Hassenpflug M, Braun SL, et al. (2011) Circulating tissue factor and microparticles are not increased in patients with deep vein thrombosis. Vasa 40:117-122.
http://www.ncbi.nlm.nih.gov/pubmed/21500176

Taniguchi M, Ono N, Hayashi A, Yakura Y, Takeya H (2011) Effect of dibutyryl cyclic adenosine monophosphate on the gene expression of plasminogen activator inhibitor-1 and tissue factor in adipocytes. Thromb Res.
http://www.ncbi.nlm.nih.gov/pubmed/21496886

Yank V, Tuohy CV, Logan AC, et al. (2011) Systematic Review: Benefits and Harms of In-Hospital Use of Recombinant Factor VIIa for Off-Label Indications. Ann Intern Med 154:529-540.
http://www.ncbi.nlm.nih.gov/pubmed/21502651
__________________________________________________________
ABOUT TRIGGER
TRIGGER is edited by Jim Morrissey and Pierre Neuenschwander, with editorial assistance by Genie Morrissey. It includes Abstracts of Papers in Press, Meeting Announcements, Positions Sought/Available,or any other pertinent item that subscribers may want to share with their colleagues. To submit an item for publication in Trigger, e-mail us. To request or cancel a subscription,or for more information about TRIGGER or the biology of tissue factor and factor VII, visit our web site. You can also contact us by mail: J.H. Morrissey, University of Illinois College of Medicine, 417 Med Sci Bldg MC-714, 506 S. Mathews Ave., Urbana, IL 61801, USA.

DISCLAIMER: TRIGGER is provided "as is" for information purposes only and without warranty of any kind, express or implied. Users shall assume the entire risk as to the accuracy and usefulness of information in TRIGGER. Opinions expressed here are not necessarily those of the editors or their employers. You may share TRIGGER with your scientific colleagues but you are not permitted to use it or its contents for commercial purposes.
__________________________________________________________

Vol. 17, No. 8

noreply@blogger.com (Pierre) — Tue, 19 Apr 2011 03:09:00 +0000

TRIGGER
The Twice-Monthly Electronic Newsletter on the Biology of Tissue Factor, Factor VII and TFPI
Vol. 17, No. 8 April 18, 2011
(The next issue will be on May 2, 2011)
__________________________________________________________
TRIGGER is also available by RSS Feed:
http://feeds.feedburner.com/blogspot/glro
and BLOG:
http://trigger-tf7.blogspot.com/
__________________________________________________________
PAPERS IN PRESS
None submitted for this issue.
__________________________________________________________
RECENT PUBLICATIONS ON TISSUE FACTOR, FACTOR VII, AND TFPI
Papers are culled from NLM MedLine (PubMed). Titles in square brackets indicate that the paper was not published in English. References that lack volume or page numbers are typically electronic pre-publications (E-pubs) ahead of the print publication; if so, the final citation with volume and page numbers may or may not appear in a future issue of Trigger.
THE FOLLOWING LINK WILL TAKE YOU TO THE ENTIRE LIST OF THIS ISSUE'S PUBLICATIONS IN A PUBMED "COLLECTION":
http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/1N_5mSvdoF2V_eJsahau8oe/

Badimon L, Storey RF, Vilahur G (2011) Update on lipids, inflammation and atherothrombosis. Thromb Haemost.
http://www.ncbi.nlm.nih.gov/pubmed/21479344

Benlakhal F, Mura T, Schved JF, Giansily-Blaizot M (2011) A retrospective analysis of 157 surgical procedures performed without replacement therapy in 83 unrelated factor VII-deficient patients. J Thromb Haemost.
http://www.ncbi.nlm.nih.gov/pubmed/21486425

Criado-Garcia J, Fuentes F, Cruz-Teno C, Garcia-Rios A, Jimenez-Morales A, Delgado-Lista J, . . . Perez-Jimenez F (2011) R353Q polymorphism in the factor VII gene and cardiovascular risk in Heterozygous Familial Hypercholesterolemia: a case-control study. Lipids Health Dis 10:50.
http://www.ncbi.nlm.nih.gov/pubmed/21477332

Fadare O, Renshaw IL, Liang SX (2011) Expression of tissue factor and heparanase in endometrial clear cell carcinoma: possible role for tissue factor in thromboembolic events. Int J Gynecol Pathol 30:252-261.
http://www.ncbi.nlm.nih.gov/pubmed/21464728

Han CS, Xin H, Han ZG, Gao ZL (2011) [Effect of tissue factor in extravascular migration of fibrosarcoma cells.]. Zhejiang Da Xue Xue Bao Yi Xue Ban 40:184-188.
http://www.ncbi.nlm.nih.gov/pubmed/21488215

Hoppe C, Kuypers F, Larkin S, Hagar W, Vichinsky E, Styles L (2011) A pilot study of the short-term use of simvastatin in sickle cell disease: effects on markers of vascular dysfunction. Br J Haematol.
http://www.ncbi.nlm.nih.gov/pubmed/21477202

Hwang SM, Kim JE, Han KS, Kim HK (2011) Thrombomodulin phenotype of a distinct monocyte subtype is an independent prognostic marker for disseminated intravascular coagulation. Crit Care 15:R113.
http://www.ncbi.nlm.nih.gov/pubmed/21489300

Jakobovic J, Butkovic D, Popovic L, Bartolek D, Stanojevic M, Barcot Z (2010) Reversal of thrombocytopenia and bleeding tendency in a preterm neonate with recombinant activated factor VII: case report. Acta Clin Croat 49:309-313.
http://www.ncbi.nlm.nih.gov/pubmed/21462821

Kilinc E, van Oerle R, Borissoff JI, Oschatz C, Gerlofs-Nijland ME, Janssen NA, . . . Spronk HM (2011) Factor XII Activation is Essential to Sustain the Procoagulant Effects of Particulate Matter. J Thromb Haemost.
http://www.ncbi.nlm.nih.gov/pubmed/21481175

Kolucki FR, Jr., Morris GJ, Thomas LC, Scialla S (2011) Factor VII deficiency in pregnancy and delivery: a case report. Haemophilia.
http://www.ncbi.nlm.nih.gov/pubmed/21492323

Marchetti M, Russo L, Balducci D, Falanga A (2011) All trans-retinoic acid modulates the procoagulant activity of human breast cancer cells. Thromb Res.
http://www.ncbi.nlm.nih.gov/pubmed/21458031

Marzano AV, Tedeschi A, Berti E, Fanoni D, Crosti C, Cugno M (2011) Activation of coagulation in bullous pemphigoid and other eosinophil-related inflammatory skin diseases. Clin Exp Immunol.
http://www.ncbi.nlm.nih.gov/pubmed/21488867

Meisel SR, Xu XP, Edgington TS, Cercek B, Ong J, Kaul S, Shah PK (2011) Dose-Dependent Modulation of Tissue Factor Protein and Procoagulant Activity in Human Monocyte-Derived Macrophages by Oxidized Low Density Lipoprotein. J Atheroscler Thromb.
http://www.ncbi.nlm.nih.gov/pubmed/21467727

Nadir Y, Kenig Y, Drugan A, Shafat I, Brenner B (2011) An assay to evaluate heparanase procoagulant activity. Thromb Res.
http://www.ncbi.nlm.nih.gov/pubmed/21481923

Nakagomi A, Sasaki M, Ishikawa Y, Shibui T, Kosugi M, Endoh Y, . . . Mizuno K (2011) Upregulation of Monocyte Tissue Factor Activity is Significantly Associated with Carotid Intima-Media Thickness in Patients with Metabolic Syndrome. J Atheroscler Thromb.
http://www.ncbi.nlm.nih.gov/pubmed/21483174

Nurden AT (2011) Platelets, inflammation and tissue regeneration. Thromb Haemost.
http://www.ncbi.nlm.nih.gov/pubmed/21479340

Pinner NA, Hurdle AC, Oliphant C, Reaves A, Lobo B, Sills A (2010) Treatment of Warfarin-Related Intracranial Hemorrhage: A Comparison of Prothrombin Complex Concentrate and Recombinant Activated Factor VII. World Neurosurg 74:631-635.
http://www.ncbi.nlm.nih.gov/pubmed/21492631

Puy C, Hermida J, Montes R (2011) Factor X and factor VII binding to EPCR differs between species. J Thromb Haemost.
http://www.ncbi.nlm.nih.gov/pubmed/21489130

Schuepbach RA, Velez K, Riewald M (2011) Activated protein C upregulates procoagulant tissue factor activity on endothelial cells by shedding TFPI's Kunitz 1 domain. Blood.
http://www.ncbi.nlm.nih.gov/pubmed/21474669

Siddiq S, Clark A, Mumford A (2011) A systematic review of the management and outcomes of pregnancy in Glanzmann thrombasthenia. Haemophilia.
http://www.ncbi.nlm.nih.gov/pubmed/21457404

Stephan F, Hazelzet JA, Bulder I, Boermeester MA, van Till JO, van der Poll T, . . . Zeerleder S (2011) Activation of factor VII-activating protease in human inflammation: a sensor for cell death. Crit Care 15:R110.
http://www.ncbi.nlm.nih.gov/pubmed/21466697

Tiede A, Friedrich U, Stenmo C, Allen G, Giangrande P, Goudemand J, . . . Berntorp E (2011) Safety and pharmacokinetics of subcutaneously administered recombinant activated factor VII (rFVIIa). J Thromb Haemost.
http://www.ncbi.nlm.nih.gov/pubmed/21489128

Uber WE, Toole JM, Stroud MR, Haney JS, Lazarchick J, Crawford FA, Jr., Ikonomidis JS (2011) Administration of recombinant activated factor VII in the intensive care unit after complex cardiovascular
surgery: Clinical and economic outcomes. J Thorac Cardiovasc Surg.
http://www.ncbi.nlm.nih.gov/pubmed/21457998

Wilmott RW (2011) Complications associated with off-label use of recombinant factor VIIa. J Pediatr 158:A2.
http://www.ncbi.nlm.nih.gov/pubmed/21482239

Wygrecka M, Kwapiszewska G, Jablonska E, von Gerlach S, Henneke I, Zakrzewicz D, . . . Markart P (2011) Role of Protease-Activated Receptor-2 in Idiopathic Pulmonary Fibrosis. Am J Respir Crit Care Med.
http://www.ncbi.nlm.nih.gov/pubmed/21471103

Yamamoto E, Nishimura N, Okada K, Sekido C, Yamamichi S, Hasumi K (2011) Inhibitors of Autoactivation of Plasma Hyaluronan-Binding Protein (Factor VII Activating Protease). Biol Pharm Bull 34:462-470.
http://www.ncbi.nlm.nih.gov/pubmed/21467630

Zhao B, Luo X, Shi H, Ma D (2011) Tissue factor pathway inhibitor-2 is downregulated by ox-LDL and inhibits ox-LDL induced vascular smooth muscle cells proliferation and migration. Thromb Res.
http://www.ncbi.nlm.nih.gov/pubmed/21458846

Zhou H, Shi W, Zhou B, Guo D, Wang T (2010) Tissue factor-factor VIIa regulates interleukin-8, tissue factor and caspase-7 expression in SW620 cells through protease-activated receptor-2 activation. Mol Med Report 3:269-274.
http://www.ncbi.nlm.nih.gov/pubmed/21472232
__________________________________________________________
ABOUT TRIGGER
TRIGGER is edited by Jim Morrissey and Pierre Neuenschwander, with editorial assistance by Genie Morrissey. It includes Abstracts of Papers in Press, Meeting Announcements, Positions Sought/Available,or any other pertinent item that subscribers may want to share with their colleagues. To submit an item for publication in Trigger, e-mail us. To request or cancel a subscription,or for more information about TRIGGER or the biology of tissue factor and factor VII, visit our web site. You can also contact us by mail: J.H. Morrissey, University of Illinois College of Medicine, 417 Med Sci Bldg MC-714, 506 S. Mathews Ave., Urbana, IL 61801, USA.

DISCLAIMER: TRIGGER is provided "as is" for information purposes only and without warranty of any kind, express or implied. Users shall assume the entire risk as to the accuracy and usefulness of information in TRIGGER. Opinions expressed here are not necessarily those of the editors or their employers. You may share TRIGGER with your scientific colleagues but you are not permitted to use it or its contents for commercial purposes.
__________________________________________________________

Vol. 17, No. 7

noreply@blogger.com (Pierre) — Mon, 04 Apr 2011 22:37:00 +0000

TRIGGER
The Twice-Monthly Electronic Newsletter on the Biology of Tissue Factor, Factor VII and TFPI
Vol. 17, No. 7 April 4, 2011
(The next issue will be on April 18, 2011)
__________________________________________________________
TRIGGER is also available by RSS Feed:
http://feeds.feedburner.com/blogspot/glro
and BLOG:
http://trigger-tf7.blogspot.com/
__________________________________________________________
PAPERS IN PRESS
None submitted for this issue.
__________________________________________________________
RECENT PUBLICATIONS ON TISSUE FACTOR, FACTOR VII, AND TFPI
Papers are culled from NLM MedLine (PubMed). Titles in square brackets indicate that the paper was not published in English. References that lack volume or page numbers are typically electronic pre-publications (E-pubs) ahead of the print publication; if so, the final citation with volume and page numbers may or may not appear in a future issue of Trigger.
THE FOLLOWING LINK WILL TAKE YOU TO THE ENTIRE LIST OF THIS ISSUE'S PUBLICATIONS IN A PUBMED "COLLECTION":
http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/12m2mfvLsV94qjWB8sgm-vG/

Agar C, de Groot PG, Morgelin M, Monk SD, van Os GM, Levels JH, . . . Meijers JC (2011) {beta}2-glycoprotein I: a novel component of innate immunity. Blood.
http://www.ncbi.nlm.nih.gov/pubmed/21454452

Altmae S, Salumets A, Bjuresten K, Kallak TK, Wanggren K, Landgren BM, . . . Stavreus-Evers A (2011) Tissue Factor and Tissue Factor Pathway Inhibitors TFPI and TFPI2 in Human Secretory Endometrium - Possible Link to Female Infertility. Reprod Sci.
http://www.ncbi.nlm.nih.gov/pubmed/21421890

Andrie RP, Bauriedel G, Braun P, Hopp HW, Nickenig G, Skowasch D (2011) Prevalence of intimal heat shock protein 60 homologues in unstable angina and correlation with anti-heat shock protein antibody titers. Basic Res Cardiol.
http://www.ncbi.nlm.nih.gov/pubmed/21416407

Chatterjee DJ, Bukunola B, Samuels TL, Induruwage L, Uncles DR (2011) Resuscitation in massive obstetric haemorrhage using an intraosseous needle*. Anaesthesia 66:306-310.
http://www.ncbi.nlm.nih.gov/pubmed/21401545

Chen Y, Qin S, Ding Y, Li S, Yang G, Zhang J, . . . Lu Y (2011) Reference values of biochemical and hematological parameters for Guizhou minipigs. Exp Biol Med (Maywood).
http://www.ncbi.nlm.nih.gov/pubmed/21427234

Cowan PJ, Robson SC, D'Apice A J (2011) Controlling coagulation dysregulation in xenotransplantation. Curr Opin Organ Transplant 16:214-221.
http://www.ncbi.nlm.nih.gov/pubmed/21415824

Dargaud Y, Prevost C, Lienhart A, Claude Bordet J, Negrier C (2011) Evaluation of the overall haemostatic effect of recombinant factor VIIa by measuring thrombin generation and stability of fibrin clots. Haemophilia.
http://www.ncbi.nlm.nih.gov/pubmed/21453422

Diedler J, Sykora M, Herweh C, Orakcioglu B, Zweckberger K, Steiner T, Hacke W (2011) [Intensive medical care of patients with intracerebral hemorrhaging.]. Nervenarzt.
http://www.ncbi.nlm.nih.gov/pubmed/21431439

Duanmu J, Cheng J, Xu J, Booth CJ, Hu Z (2011) Effective treatment of chemoresistant breast cancer in vitro and in vivo by a factor VII-targeted photodynamic therapy. Br J Cancer.
http://www.ncbi.nlm.nih.gov/pubmed/21427724

Gandhi DA, Shrewsberry T (2011) Thromboelastograph guided management of a patient requiring Abiomed biventricular support with consumptive coagulopathy. J Extra Corpor Technol 43:26-29.
http://www.ncbi.nlm.nih.gov/pubmed/21449231

Girolami A, Candeo N, Bonamigo E, Fabris F (2011) Arg 304 Gln (FVII Padua) and Ala 294 Val mutations are equally present in patients with FVII deficiency and thrombosis. Eur J Haematol.
http://www.ncbi.nlm.nih.gov/pubmed/21453389

Grochova M, Kalnasova B, Firment J, Olejarova I, Roland R, Lazurova I (2011) Pulmonary administration of activated recombinant factor VII. Bratisl Lek Listy 112:29-33.
http://www.ncbi.nlm.nih.gov/pubmed/21452776

Karpf DM, Sorensen BB, Hermit MB, Holmberg HL, Tranholm M, Bysted BV,. . . Stennicke HR (2011) Prolonged half-life of glycoPEGylated rFVIIa variants compared to native rFVIIa. Thromb Res.
http://www.ncbi.nlm.nih.gov/pubmed/21429564

Kilinc E, Schulz H, Kuiper GJ, Spronk HM, Ten Cate H, Upadhyay S, . . . Wichmann HE (2011) The procoagulant effects of fine particulate matter in vivo. Part Fibre Toxicol 8:12.
http://www.ncbi.nlm.nih.gov/pubmed/21406084

Kogiso N, Taki M, Takamiya O (2011) Factor VII Deficiency due to Compound Heterozygosity for Leu-48Pro Mutation and a Novel Pro260Leu Mutation. Clin Appl Thromb Hemost.
http://www.ncbi.nlm.nih.gov/pubmed/21441234

Kotani Y, Shiota M, Umemoto M, Koike E, Tsuritani M, Hoshiai H (2011) Case of acquired hemophilia with factor VIII inhibitor in a mother and newborn. J Obstet Gynaecol Res.
http://www.ncbi.nlm.nih.gov/pubmed/21450023

Lauer S, Westphal M, Fischer LG, Meissner A, Van Aken H, Freise H (2011) Recombinant factor VIIa and factor VIII treatment for acquired factor VIII deficiency: a case of repeated thrombotic endotracheal occlusion in a mechanically ventilated patient. Crit Care 15:407.
http://www.ncbi.nlm.nih.gov/pubmed/21418550

Li D, Guo R, Chen QQ, Hu CP, Chen X (2011) Increased plasma level of asymmetric dimethylarginine in hypertensive rats facilitates platelet aggregation: role of plasma tissue factor. Can J Physiol Pharmacol 89:151-158.
http://www.ncbi.nlm.nih.gov/pubmed/21423288

Lorente L, Martin MM, Varo N, Borreguero-Leon JM, Sole-Violan J, Blanquer J, . . . Paramo JA (2011) Association between serum soluble CD40 ligand levels and mortality in patients with severe sepsis. Crit Care 15:R97.
http://www.ncbi.nlm.nih.gov/pubmed/21406105

Mahmoodi M, Peyvandi F, Afrasiabi A, Ghaffarpasand F, Karimi M (2011) Bleeding symptoms in heterozygous carriers of inherited coagulation disorders in southern Iran. Blood Coagul Fibrinolysis.
http://www.ncbi.nlm.nih.gov/pubmed/21451397

Marti-Carvajal AJ, Comunian-Carrasco G, Pena-Marti GE (2011) Haematological interventions for treating disseminated intravascular coagulation during pregnancy and postpartum. Cochrane Database Syst Rev 3:CD008577.
http://www.ncbi.nlm.nih.gov/pubmed/21412921

McDowell SA, Ma Y, Kusano R, Akinbi HT (2011) Simvastatin is Protective During Staphylococcus aureus Pneumonia. Curr Pharm Biotechnol.
http://www.ncbi.nlm.nih.gov/pubmed/21401521

Mortensen LS, Thomsen C, Hermansen K (2010) Effects of Different Protein Sources on Plasminogen Inhibitor-1 and Factor VII Coagulant Activity Added to a Fat-Rich Meal in Type 2 Diabetes. Rev Diabet Stud 7:233-240.
http://www.ncbi.nlm.nih.gov/pubmed/21409315

Mukherjee SD, Swystun LL, Mackman N, Wang JG, Pond G, Levine MN, Liaw PC (2011) Impact of Chemotherapy on Thrombin Generation and on the Protein C Pathway in Breast Cancer Patients. Pathophysiol Haemost Thromb.
http://www.ncbi.nlm.nih.gov/pubmed/21430357

Nascimento B, Lin Y, Callum J, Reis M, Pinto R, Rizoli S (2011) Recombinant factor VIIa is associated with an improved 24-hour survival without an improvement in inpatient survival in massively transfused civilian trauma patients. Clinics (Sao Paulo) 66:101-106.
http://www.ncbi.nlm.nih.gov/pubmed/21437444

Okubo Y, Wakayama M, Kitahara K, Nemoto T, Yokose T, Abe F, . . . Shibuya K (2011) Pulmonary tumor thrombotic microangiopathy induced by gastric carcinoma: Morphometric and immunohistochemical analysis of six autopsy cases. Diagn Pathol 6:27.
http://www.ncbi.nlm.nih.gov/pubmed/21450103

Pike GN, Bolton-Maggs PH (2011) Factor deficiencies in pregnancy. Hematol Oncol Clin North Am 25:359-378.
http://www.ncbi.nlm.nih.gov/pubmed/21444035

Pirzer R, Elmas E, Haghi D, Lippert C, Kralev S, Lang S, . . . Kalsch T (2011) Platelet and monocyte activity markers and mediators of inflammation in Takotsubo cardiomyopathy. Heart Vessels.
http://www.ncbi.nlm.nih.gov/pubmed/21416113

Plesner B, Westh P, Hvidt S, Nielsen AD (2011) The molar hydrodynamic volume changes of factor VIIa due to GlycoPEGylation. J Pharm Biomed Anal.
http://www.ncbi.nlm.nih.gov/pubmed/21429688

Rao B, Gao Y, Huang J, Gao X, Fu X, Huang M, . . . Wang L (2011) Mutations of p53 and K-ras correlate TF expression in human colorectal carcinomas: TF downregulation as a marker of poor
prognosis. Int J Colorectal Dis.
http://www.ncbi.nlm.nih.gov/pubmed/21404058

Sebag SC, Bastarache JA, Ware LB (2011) Therapeutic Modulation of Coagulation and Fibrinolysis in Acute Lung Injury and the Acute Respiratory Distress Syndrome. Curr Pharm Biotechnol.
http://www.ncbi.nlm.nih.gov/pubmed/21401517

Setty S, Reddell A, England A, Gomez K, Kadir R (2011) The role of recombinant factor VIIa for obstetric block in women with severe factor XI deficiency. Haemophilia.
http://www.ncbi.nlm.nih.gov/pubmed/21453421

Vang ML, Hvas AM, Ravn HB (2011) Urgent reversal of vitamin K antagonist therapy. Acta Anaesthesiol Scand.
http://www.ncbi.nlm.nih.gov/pubmed/21418150

Willis CD, Jolley DJ, McNeil JJ, Cameron PA, Phillips LE (2011) Identifying and improving unreliable items in registries through data auditing. Int J Qual Health Care.
http://www.ncbi.nlm.nih.gov/pubmed/21441251

Wilson B, Means RT, Jr. (2011) Acquired Factor VIII Inhibitor as Initial Manifestation of Collagen Vascular Disease: Response to Combination Immunosuppression as First-Line Therapy. Am J Med Sci.
http://www.ncbi.nlm.nih.gov/pubmed/21412135

Yada K, Nogami K, Ogiwara K, Shibata M, Shima M (2011) Effects of anti-factor VIII inhibitor antibodies on factor VIIa/tissue factor-catalysed activation and inactivation of factor VIII. Thromb
Haemost 105.
http://www.ncbi.nlm.nih.gov/pubmed/21437361
__________________________________________________________
ABOUT TRIGGER
TRIGGER is edited by Jim Morrissey and Pierre Neuenschwander, with editorial assistance by Genie Morrissey. It includes Abstracts of Papers in Press, Meeting Announcements, Positions Sought/Available,or any other pertinent item that subscribers may want to share with their colleagues. To submit an item for publication in Trigger, e-mail us. To request or cancel a subscription,or for more information about TRIGGER or the biology of tissue factor and factor VII, visit our web site. You can also contact us by mail: J.H. Morrissey, University of Illinois College of Medicine, 417 Med Sci Bldg MC-714, 506 S. Mathews Ave., Urbana, IL 61801, USA.

DISCLAIMER: TRIGGER is provided "as is" for information purposes only and without warranty of any kind, express or implied. Users shall assume the entire risk as to the accuracy and usefulness of information in TRIGGER. Opinions expressed here are not necessarily those of the editors or their employers. You may share TRIGGER with your scientific colleagues but you are not permitted to use it or its contents for commercial purposes.
__________________________________________________________

Vol. 17, No. 6

noreply@blogger.com (Pierre) — Tue, 15 Mar 2011 20:00:00 +0000

TRIGGER
The Twice-Monthly Electronic Newsletter on the Biology of Tissue Factor, Factor VII and TFPI
Vol. 17, No. 6 March 15, 2011
(The next issue will be on April 1, 2011)
__________________________________________________________
TRIGGER is also available by RSS Feed:
http://feeds.feedburner.com/blogspot/glro
and BLOG:
http://trigger-tf7.blogspot.com/
__________________________________________________________
PRODUCT ANNOUNCEMENT

Haematologic Technologies, Inc. supplies a full range of purified proteins and antibodies for use in thrombosis research. These proteins include:

Purified cogulation factors - purified from human plasma, and greater than 95% pure by SDS-PAGE.

http://www.haemtech.com/Products_Overview.htm

Antibodies - Monoclonal, polyclonal and conjugated forms are available.

http://www.haemtech.com/Antibodies.htm

Custom blood collection tubes - customized to your specifications. Non-sterile, research use only.

http://www.haemtech.com/Blood_Collection_Tubes.htm

Contact customer service (rmyers AT haemtech DOT com) for additional information or simply visit our website via the links above. Please include "Trigger" in the subject line.

DISCLAIMER: Commercial product announcements appearing in TRIGGER are provided "as is" for informational purposes only. The editors of TRIGGER have not necessarily evaluated any materials from commercial suppliers described in this newsletter or on its web sites, and we certainly are not endorsing any specific suppliers or products. Furthermore, the editors receive no revenues from any source in the course of publishing TRIGGER.
__________________________________________________________
PAPERS IN PRESS
None submitted for this issue.
__________________________________________________________
RECENT PUBLICATIONS ON TISSUE FACTOR, FACTOR VII, AND TFPI
Papers are culled from NLM MedLine (PubMed). Titles in square brackets indicate that the paper was not published in English. References that lack volume or page numbers are typically electronic pre-publications (E-pubs) ahead of the print publication; if so, the final citation with volume and page numbers may or may not appear in a future issue of Trigger.
THE FOLLOWING LINK WILL TAKE YOU TO THE ENTIRE LIST OF THIS ISSUE'S PUBLICATIONS IN A PUBMED "COLLECTION":
http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/1FGVdsJU0ltAxZc9wpEu1M6/

(No authors listed) (2010) [Diagnosis and correction of thrombohemorrhagic complications in cardiosurgical patients in the early postoperative period]. Anesteziol Reanimatol:56-59.
http://www.ncbi.nlm.nih.gov/pubmed/21400731

Agerso H, Kristensen NR, Ostergaard H, Karpf DM, Hermit MB, Pelzer H, . . . Ezban M (2011) Clearance of rFVIIa and NN1731 after intravenous administration to Beagle dogs. Eur J Pharm Sci.
http://www.ncbi.nlm.nih.gov/pubmed/21382491

Brophy DF, Martin EJ, Christian Barrett J, Nolte ME, Kuhn JG, Gerk PM, . . . Hedner U (2011) Monitoring rFVIIa 90 mug kg(-1) dosing in haemophiliacs: comparing laboratory response using various whole blood assays over 6 h. Haemophilia.
http://www.ncbi.nlm.nih.gov/pubmed/21362113

Brown C, Joshi B, Faraday N, Shah A, Yuh D, Rade JJ, Hogue CW (2011) Emergency Cardiac Surgery in Patients with Acute Coronary Syndromes: A Review of the Evidence and Perioperative Implications of Medical and Mechanical Therapeutics. Anesth Analg.
http://www.ncbi.nlm.nih.gov/pubmed/21385977

Christensen MC, Banner C, Lefering R, Vallejo-Torres L, Morris S (2011) Quality of Life After Severe Trauma: Results From the Global Trauma Trial With Recombinant Factor VII. J Trauma.
http://www.ncbi.nlm.nih.gov/pubmed/21378585

Delluc A, Rousseau A, Delluc C, Le Moigne E, Le Gal G, Mottier D, . . . Lacut K (2011) Venous thromboembolism in patients with pancreatic cancer: implications of circulating tissue factor. Blood Coagul Fibrinolysis.
http://www.ncbi.nlm.nih.gov/pubmed/21372691

Dimou AT, Syrigos KN, Saif MW (2011) Novel Agents in the Management of Pancreatic Adenocarcinoma: Phase I Studies. Highlights from the "2011 ASCO Gastrointestinal Cancers Symposium". San Francisco, CA, USA. January 20-22, 2011. JOP 12:114-116.
http://www.ncbi.nlm.nih.gov/pubmed/21386633

Eisenreich A, Boltzen U, Malz R, Schultheiss HP, Rauch U (2011) Overexpression of Alternatively Spliced Tissue Factor Induces the Pro-Angiogenic Properties of Murine Cardiomyocytic HL-1 Cells. Circ J.
http://www.ncbi.nlm.nih.gov/pubmed/21389637

Ferraris VA, Brown JR, Despotis GJ, Hammon JW, Reece TB, Saha SP, . . . Shann KG (2011) 2011 update to the society of thoracic surgeons and the society of cardiovascular anesthesiologists blood conservation clinical practice guidelines. Ann Thorac Surg 91:944-982.
http://www.ncbi.nlm.nih.gov/pubmed/21353044

Gando S, Sawamura A, Hayakawa M (2011) Trauma, Shock, and Disseminated Intravascular Coagulation: Lessons from the Classical Literature. Ann Surg.
http://www.ncbi.nlm.nih.gov/pubmed/21368657

Ho KM, Leonard AD (2011) Concentration-dependent effect of hypocalcaemia on mortality of patients with critical bleeding requiring massive transfusion: a cohort study. Anaesth Intensive Care 39:46-54.
http://www.ncbi.nlm.nih.gov/pubmed/21375089

Holmberg H, Kiersgaard MK, Mikkelsen LF, Tranholm M (2011) Impact of blood sampling technique on blood quality and animal welfare in haemophilic mice. Lab Anim.
http://www.ncbi.nlm.nih.gov/pubmed/21382833

Ignjatovic V, Than J, Summerhayes R, Newall F, Horton S, Cochrane A, Monagle P (2011) Hemostatic Response in Paediatric Patients Undergoing Cardiopulmonary Bypass Surgery. Pediatr Cardiol.
http://www.ncbi.nlm.nih.gov/pubmed/21360266

Jiang M, Wang Z, Yu Z, Bai X, Su J, Cao L, . . . Ruan C (2011) A novel missense mutation close to the charge-stabilizing system in a patient with congenital factor VII deficiency. Blood Coagul Fibrinolysis.
http://www.ncbi.nlm.nih.gov/pubmed/21372693

Kayem G, Kurinczuk J, Alfirevic Z, Spark P, Brocklehurst P, Knight M (2011) Specific second-line therapies for postpartum haemorrhage: a national cohort study. BJOG.
http://www.ncbi.nlm.nih.gov/pubmed/21392247

Krysiak R, Zmuda W, Okopien B (2011) The effect of ezetimibe and simvastatin on hemostasis in patients with isolated hypercholesterolemia. Fundam Clin Pharmacol.
http://www.ncbi.nlm.nih.gov/pubmed/21392096

Kung CW, Lee YM, Yen MH (2011) In vivo anticoagulant effect of ethyl pyruvate in endotoxemic rats. Thromb Res.
http://www.ncbi.nlm.nih.gov/pubmed/21396682

Lockwood CJ, Huang SJ, Krikun G, Caze R, Rahman M, Buchwalder LF, Schatz F (2011) Decidual hemostasis, inflammation, and angiogenesis in pre-eclampsia. Semin Thromb Hemost 37:158-164.
http://www.ncbi.nlm.nih.gov/pubmed/21370218

Lwaleed BA, Dusse L, Cooper AJ (2011) Tissue factor dependent pathway and the diagnosis of pre-eclampsia. Semin Thromb Hemost 37:125-130.
http://www.ncbi.nlm.nih.gov/pubmed/21370212

Machlus KR, Cardenas JC, Church FC, Wolberg AS (2011) Causal relationship between hyperfibrinogenemia, thrombosis, and resistance to thrombolysis in mice. Blood.
http://www.ncbi.nlm.nih.gov/pubmed/21355090

Morfini M, Bjerre J (2011) Pharmacokinetics and safety of a 270 mcg kg(-1) dose of room temperature stable recombinant activated factor VII in patients with haemophilia. Haemophilia.
http://www.ncbi.nlm.nih.gov/pubmed/21371194

Negrev N, Tashev R, Radev R, Anogeianaki A, Ivanova M (2011) Hormones of hypothalamic-pituitary-thyroid axis are significant regulators of synthesis and secretion of vitamin K-dependent plasma coagulation factors. J Biol Regul Homeost Agents 25:21-26.
http://www.ncbi.nlm.nih.gov/pubmed/21382270

Ott I (2011) Inhibitors of the initiation of coagulation. Br J Clin Pharmacol.
http://www.ncbi.nlm.nih.gov/pubmed/21392058

Rochier A, Nixon A, Yamashita N, Abe R, Madri JA, Sumpio BE (2011) Laminar shear, but not orbital shear, has a synergistic effect with thrombin stimulation on tissue factor expression in human umbilical vein endothelial cells. J Vasc Surg.
http://www.ncbi.nlm.nih.gov/pubmed/21367569

Sakai T, Inoue S, Takei M, Ogawa G, Hamazaki Y, Ota H, Koboyashi Y (2011) Activated inflammatory cells participate in thrombus size through tissue factor and plasminogen activator inhibitor-1 in acute coronary syndrome: Immunohistochemical analysis. Thromb Res.
http://www.ncbi.nlm.nih.gov/pubmed/21388659

Schweintzger S, Schlagenhauf A, Leschnik B, Rinner B, Bernhard H, Novak M, Muntean W (2011) Microparticles in newborn cord blood: Slight elevation after normal delivery. Thromb Res.
http://www.ncbi.nlm.nih.gov/pubmed/21376371

Uszynski M, Uszynski W (2011) Coagulation and fibrinolysis in amniotic fluid: physiology and observations on amniotic fluid embolism, preterm fetal membrane rupture, and pre-eclampsia. Semin Thromb Hemost 37:165-174.
http://www.ncbi.nlm.nih.gov/pubmed/21370219

van den Born BJ, Lowenberg EC, van der Hoeven NV, de Laat B, Meijers JC, Levi M, van Montfrans GA (2011) Endothelial dysfunction, platelet activation, thrombogenesis and fibrinolysis in patients with hypertensive crisis. J Hypertens.
http://www.ncbi.nlm.nih.gov/pubmed/21372741

Waters EK, Genga RM, Schwartz MC, Nelson JA, Schaub RG, Olson KA, . . . McGinness KE (2011) Aptamer ARC19499 mediates a procoagulant hemostatic effect by inhibiting tissue factor pathway inhibitor. Blood.
http://www.ncbi.nlm.nih.gov/pubmed/21389323

Yang Y, Yan FZ, Yan JS, Zhao J, Li WP, Chen XY, . . . Rao SM (2011) [Screening Drugs for Regulating Tissue Factor Gene Expression.]. Zhongguo Shi Yan Xue Ye Xue Za Zhi 19:207-210.
http://www.ncbi.nlm.nih.gov/pubmed/21362253
__________________________________________________________
ABOUT TRIGGER
TRIGGER is edited by Jim Morrissey and Pierre Neuenschwander, with editorial assistance by Genie Morrissey. It includes Abstracts of Papers in Press, Meeting Announcements, Positions Sought/Available,or any other pertinent item that subscribers may want to share with their colleagues. To submit an item for publication in Trigger, e-mail us. To request or cancel a subscription,or for more information about TRIGGER or the biology of tissue factor and factor VII, visit our web site. You can also contact us by mail: J.H. Morrissey, University of Illinois College of Medicine, 417 Med Sci Bldg MC-714, 506 S. Mathews Ave., Urbana, IL 61801, USA.

Vol. 17, No. 5

noreply@blogger.com (Pierre) — Wed, 02 Mar 2011 02:26:00 +0000

TRIGGER
The Twice-Monthly Electronic Newsletter on the Biology of Tissue Factor, Factor VII and TFPI
Vol. 17, No. 5 March 1, 2011
(The next issue will be on March 15, 2011)
__________________________________________________________
TRIGGER is also available by RSS Feed:
http://feeds.feedburner.com/blogspot/glro
and BLOG:
http://trigger-tf7.blogspot.com/
__________________________________________________________
PAPERS IN PRESS
None submitted for this issue.
__________________________________________________________
RECENT PUBLICATIONS ON TISSUE FACTOR, FACTOR VII, AND TFPI
Papers are culled from NLM MedLine (PubMed). Titles in square brackets indicate that the paper was not published in English. References that lack volume or page numbers are typically electronic pre-publications (E-pubs) ahead of the print publication; if so, the final citation with volume and page numbers may or may not appear in a future issue of Trigger.
THE FOLLOWING LINK WILL TAKE YOU TO THE ENTIRE LIST OF THIS ISSUE'S PUBLICATIONS IN A PUBMED "COLLECTION":
http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/1LcGpRiwj-TTKweA_g5-527/

Abdel-Bakky MS, Hammad MA, Walker LA, Ashfaq MK (2011) Silencing of tissue factor by antisense deoxyoligonucleotide prevents monocrotaline/LPS renal injury in mice. Arch Toxicol.
http://www.ncbi.nlm.nih.gov/pubmed/21327618

Almagro D, Agramonte O, Castillo D, Zamora Y, Ballester JM (2011) Experience with a single dose of recombinant activated factor VII for the management of mild-to-moderate bleeds in haemophilia. Haemophilia 17:322-323.
http://www.ncbi.nlm.nih.gov/pubmed/21332884

Bhat S, Yadav SP, Anjan M, Dinand V, Sachdeva A (2011) Recombinant Activated Factor VII Usage in Life Threatening Hemorrhage: A Pediatric Experience. Indian J Pediatr.
http://www.ncbi.nlm.nih.gov/pubmed/21328080

Caviglia H, Candela M, Galatro G, Neme D, Moretti N, Bianco RP (2011) Elective orthopaedic surgery for haemophilia patients with inhibitors: single centre experience of 40 procedures and review of the literature. Haemophilia.
http://www.ncbi.nlm.nih.gov/pubmed/21342367

Di Santo A, Amore C, Dell'elba G, Manarini S, Evangelista V (2011) Glycogen synthase kinase-3 negatively regulates tissue factor expression in monocytes interacting with activated platelets. J Thromb Haemost.
http://www.ncbi.nlm.nih.gov/pubmed/21320285

Gringeri A, Fischer K, Karafoulidou A, Klamroth R, Lopez-Fernandez MF, Mancuso E (2011) Sequential combined bypassing therapy is safe and effective in the treatment of unresponsive bleeding in adults and children with haemophilia and inhibitors. Haemophilia.
http://www.ncbi.nlm.nih.gov/pubmed/21323801

Guglielmone H, Jarchum G, Minoldo S (2011) Liver transplantation in a patient with mild haemophilia A and low-titres of factor VIII inhibitors treated with recombinant factor VIIa. The first Argentinean case. Haemophilia 17:317-318.
http://www.ncbi.nlm.nih.gov/pubmed/21332883

Henriquez S, Calderon C, Quezada M, Oliva B, Bravo ML, Aranda E, . . . Owen GI (2011) Progesterone utilizes distinct membrane pools of tissue factor to increase coagulation and invasion and these effects are inhibited by TFPI. J Cell Physiol.
http://www.ncbi.nlm.nih.gov/pubmed/21344386

Ji M, Yi S, Smith-Hurst H, Phillips P, Wu J, Hawthorne W, O'Connell P (2011) The Importance of Tissue Factor Expression by Porcine NICC in Triggering IBMIR in the Xenograft Setting. Transplantation.
http://www.ncbi.nlm.nih.gov/pubmed/21325994

Lin Y, Stanworth S, Birchall J, Doree C, Hyde C (2011) Recombinant factor VIIa for the prevention and treatment of bleeding in patients without haemophilia. Cochrane Database Syst Rev 2:CD005011.
http://www.ncbi.nlm.nih.gov/pubmed/21328270

Margaritis P, Roy E, Faella A, Downey HD, Ivanciu L, Pavani G, . . . High KA (2011) Catalytic domain modification and viral gene delivery of activated Factor VII confers hemostasis at reduced expression levels and vector doses in vivo. Blood.
http://www.ncbi.nlm.nih.gov/pubmed/21325603

Mitra B, Cameron PA, Parr MJ, Phillips L (2011) Recombinant factor VIIa in trauma patients with the 'triad of death'. Injury.
http://www.ncbi.nlm.nih.gov/pubmed/21345431

Poursafa P, Kelishadi R, Lahijanzadeh A, Modaresi M, Javanmard SH, Assari R, . . . Sadeghian B (2011) The relationship of air pollution and surrogate markers of endothelial dysfunction in a population-based sample of children. BMC Public Health 11:115.
http://www.ncbi.nlm.nih.gov/pubmed/21332998

Swystun LL, Mukherjee S, Levine M, Liaw PC (2011) The chemotherapy metabolite acrolein upregulates thrombin generation and impairs the protein C anticoagulant pathway in animal- and cell-based models. J Thromb Haemost.
http://www.ncbi.nlm.nih.gov/pubmed/21320281

Thabut D, Rudler M, Rousseau G, Poynard T (2011) Recombinant Activated factor VII in chronic liver diseases: should we be afraid of thromboembolic events? J Hepatol.
http://www.ncbi.nlm.nih.gov/pubmed/21349297

van der Poll T, Boer JD, Levi M (2011) The effect of inflammation on coagulation and vice versa. Curr Opin Infect Dis.
http://www.ncbi.nlm.nih.gov/pubmed/21330919
__________________________________________________________
ABOUT TRIGGER
TRIGGER is edited by Jim Morrissey and Pierre Neuenschwander, with editorial assistance by Genie Morrissey. It includes Abstracts of Papers in Press, Meeting Announcements, Positions Sought/Available,or any other pertinent item that subscribers may want to share with their colleagues. To submit an item for publication in Trigger, e-mail us. To request or cancel a subscription,or for more information about TRIGGER or the biology of tissue factor and factor VII, visit our web site. You can also contact us by mail: J.H. Morrissey, University of Illinois College of Medicine, 417 Med Sci Bldg MC-714, 506 S. Mathews Ave., Urbana, IL 61801, USA.

Vol. 17, No. 4

noreply@blogger.com (Pierre) — Wed, 16 Feb 2011 00:16:00 +0000

TRIGGER
The Twice-Monthly Electronic Newsletter on the Biology of Tissue Factor, Factor VII and TFPI
Vol. 17, No. 4 February 15, 2011
(The next issue will be on March 1, 2011)
__________________________________________________________
TRIGGER is also available by RSS Feed:
http://feeds.feedburner.com/blogspot/glro
and BLOG:
http://trigger-tf7.blogspot.com/
__________________________________________________________
PRODUCT ANNOUNCEMENT

The Asserachrom® VIIa-AT product from Diagnostica Stago, Inc. (catalog #00491) is a new kit for the analysis of plasma circulating factor VIIa-antithrombin (FVIIa-AT) complex levels by the ELISA method, and can be run on any plate reader reporting at 450 nm. The kit is labeled for research use only, not for use in diagnostic procedures worldwide. This new product, the first of its kind is useful for looking at FVIIa-AT, and thus coagulation activation in prothrombotic disease states such as arterial and veneous thrombosis.

Unlike the FVIIa-TFPI complex, which stays bound to the endothelium, FVIIa-AT is released into the blood upon coagulation activation, making it a useful marker for this phenomenon. Use of this kit has been reported using plasmas from research subjects exhibiting hypercoagulability as a result of hemotological neoplasia (1) as well as factor VII deficiency (2). In addition, samples from patients on oral anticoagulation were examined using this kit (2). Other studies have also shown elevation of FVIIa-AT in antiphospholipid syndrome (3) and recent myocardial infarction (4).

For more information, please contact Paul Riley, PhD; 973-631-1200 x4238, (paul DOT riley AT stago-us DOT com).

1. H. F. Negaard et al., Thromb Haemost 99, 1040 (Jun, 2008).
2. L. Spiezia et al., Thromb Haemost 103, 1188 (Jun, 2010).
3. R. A. S. Roubey, T. Lovell, J. H. Morrissey, J. Thromb. Haemostasis 5, Abstract from the XXIst Congress of the ISTH (2007).
4. A. Silveira et al., J. Thromb. Haemostasis 5, Abstract from the XXIst Congress of the ISTH (2007).

DISCLAIMER: Commercial product announcements appearing in TRIGGER are provided "as is" for informational purposes only. The editors of TRIGGER have not necessarily evaluated any materials from commercial suppliers described in this newsletter or on its web sites, and we certainly are not endorsing any specific suppliers or products. Furthermore, the editors receive no revenues from any source in the course of publishing TRIGGER.
__________________________________________________________
PAPERS IN PRESS
None submitted for this issue.
__________________________________________________________
RECENT PUBLICATIONS ON TISSUE FACTOR, FACTOR VII, AND TFPI
Papers are culled from NLM MedLine (PubMed). Titles in square brackets indicate that the paper was not published in English. References that lack volume or page numbers are typically electronic pre-publications (E-pubs) ahead of the print publication; if so, the final citation with volume and page numbers may or may not appear in a future issue of Trigger.
THE FOLLOWING LINK WILL TAKE YOU TO THE ENTIRE LIST OF THIS ISSUE'S PUBLICATIONS IN A PUBMED "COLLECTION":
http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/1hSOFnEHt3QvVFLxFWGkaMI/

Arellano-Rodrigo E (2011) Safety of recombinant activated factor VII in randomized clinical trials. N Engl J Med 364:574-575; author reply 575-576.
http://www.ncbi.nlm.nih.gov/pubmed/21306249

Berny-Lang MA, Aslan JE, Tormoen GW, Patel IA, Bock PE, Gruber A, McCarty OJ (2011) Promotion of experimental thrombus formation by the procoagulant activity of breast cancer cells. Phys Biol 8:015014.
http://www.ncbi.nlm.nih.gov/pubmed/21301066

Collier ME, Ettelaie C (2011) Regulation of the incorporation of tissue factor into microparticles by serine phosphorylation of the cytoplasmic domain of tissue factor. J Biol Chem.
http://www.ncbi.nlm.nih.gov/pubmed/21310953

Emekli-Alturfan E, Basar I, Malali E, Elemek E, Oktay S, Ayan F, . . . Noyan U (2011) Plasma Tissue Factor Levels and Salivary Tissue Factor Activities of Periodontitis Patients with and without Cardiovascular Disease. Pathophysiol Haemost Thromb.
http://www.ncbi.nlm.nih.gov/pubmed/21293108

Franchini M, Targher G, Lippi G (2011) Safety of recombinant activated factor VII in randomized clinical trials. N Engl J Med 364:575; author reply 575-576.
http://www.ncbi.nlm.nih.gov/pubmed/21306247

Gavins FN, Russell J, Senchenkova EL, De Almeida Paula L, Damazo AS, Esmon CT, . . . Granger DN(2011) Mechanisms of enhanced thrombus formation in cerebral microvessels of mice expressing hemoglobin-S. Blood.
http://www.ncbi.nlm.nih.gov/pubmed/21304105

Gidaris D, Economou M, Valeri R, Gombakis N, Athanasiou-Metaxa M (2010) Successful treatment of a spontaneous haemothorax with recombinant factor VIIa in a haemophilic child with inhibitors. Hippokratia 14:289-290.
http://www.ncbi.nlm.nih.gov/pubmed/21311642

Gustafson EK, Elgue G, Hughes RD, Mitry RR, Sanchez J, Haglund U, . . . Nilsson B (2011) The Instant Blood-Mediated Inflammatory Reaction Characterized in Hepatocyte Transplantation. Transplantation.
http://www.ncbi.nlm.nih.gov/pubmed/21289595

Hoffman M, Volovyk Z, Persson E, Gabriel DA, Ezban M, Monroe DM (2011) Platelet binding and activity of a factor VIIa variant with enhanced tissue factor independent activity. J Thromb Haemost.
http://www.ncbi.nlm.nih.gov/pubmed/21294824

Jenabali Jahromi B, Karimi M (2011) Long-term follow-up of prophylaxis with recombinant activated factor VII in patients with congenital factor VII deficiency. Haemophilia.
http://www.ncbi.nlm.nih.gov/pubmed/21299748

Jiang W, Kou J, Yuan S, Sun L, Yu B (2011) A Simplified and High-Throughput Chromogenic Assay for Testing Tissue Factor-Dependent Procoagulant Activity. J Biomol Screen.
http://www.ncbi.nlm.nih.gov/pubmed/21310849

Jin Y, Wang M, Niu Z, Xie Y, Xie H, Yang L (2011) [An inherited coagulation factor VII deficiency pedigree caused by homozygous mutation of His348Gln.]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 28:10-13.
http://www.ncbi.nlm.nih.gov/pubmed/21287501

Keyl C, Uhl R, Beyersdorf F, Stampf S, Lehane C, Wiesenack C, Trenk D (2011) High-dose tranexamic acid is related to increased risk of generalized seizures after aortic valve replacement. Eur J Cardiothorac Surg.
http://www.ncbi.nlm.nih.gov/pubmed/21295991

Koci J, Dedek T, Havel E, Trlica J (2011) Recombinant Activated Factor VII-"Lifesaving or Surgeon Correcting"? J Trauma 70:523-524.
http://www.ncbi.nlm.nih.gov/pubmed/21307759

Kostovski E, Dahm AE, Iversen N, Hjeltnes N, Osterud B, Sandset PM, Iversen PO (2011) Melatonin stimulates release of tissue factor pathway inhibitor from the vascular endothelium. Blood Coagul Fibrinolysis.
http://www.ncbi.nlm.nih.gov/pubmed/21297449

Marzano AV, Tedeschi A, Rossio R, Fanoni D, Cugno M (2010) Prothrombotic state in Churg-Strauss syndrome: a case report. J Investig Allergol Clin Immunol 20:616-619.
http://www.ncbi.nlm.nih.gov/pubmed/21314005

Mazer CD, Leong-Poi H, Chhina T, Alfardan Z, Lapierre H, Wang Z, . . . Teitel J (2011) Recombinant factor VIIa affects anastomotic patency of vascular grafts in a rabbit model. J Thorac Cardiovasc Surg.
http://www.ncbi.nlm.nih.gov/pubmed/21281943

Neufeld EJ, Kessler CM, Gill JC, Wilke CT, Cooper DL (2011) Exposure and safety of higher doses of recombinant factor VIIa >/=250 mug kg(-1) in individuals with congenital haemophilia complicated by alloantibody inhibitors: the Haemophilia and Thrombosis Research Society Registry experience (2004-2008). Haemophilia.
http://www.ncbi.nlm.nih.gov/pubmed/21299750

Patel A, Cooper N, Laffan MA (2011) Safety of recombinant activated factor VII in randomized clinical trials. N Engl J Med 364:574; author reply 575-576.
http://www.ncbi.nlm.nih.gov/pubmed/21306250

Potzsch B, Ivaskevicius V (2011) Haemostasis management of massive bleeding. Hamostaseologie 31:15-20.
http://www.ncbi.nlm.nih.gov/pubmed/21311819

Regnault V, Perret-Guillaume C, Kearney-Schwartz A, Max JP, Labat C, Louis H, . . . Lacolley P (2011) Tissue Factor Pathway Inhibitor: A New Link Among Arterial Stiffness, Pulse Pressure, and Coagulation in Postmenopausal Women. Arterioscler Thromb Vasc Biol.
http://www.ncbi.nlm.nih.gov/pubmed/21293010

Shing CM, Adams MJ, Fassett RG, Coombes JS (2011) Nutritional compounds influence tissue factor expression and inflammation of chronic kidney disease patients in vitro. Nutrition.
http://www.ncbi.nlm.nih.gov/pubmed/21295946

Valentino LA, Cooper DL, Goldstein B (2011) Surgical Experience with rFVIIa (NovoSeven) in congenital haemophilia A and B patients with inhibitors to factors VIII or IX. Haemophilia.
http://www.ncbi.nlm.nih.gov/pubmed/21294815

Wunderink RG, Laterre PF, Francois B, Perrotin D, Artigas A, Vidal LO, . . . Opal S (2011) Recombinant Tissue Factor Pathway Inhibitor in Severe Community-Acquired Pneumonia: A Randomized Trial. Am J Respir Crit Care Med.
http://www.ncbi.nlm.nih.gov/pubmed/21297074

Yank V, Stafford RS (2011) Safety of recombinant activated factor VII in randomized clinical trials. N Engl J Med 364:575; author reply 575-576.
http://www.ncbi.nlm.nih.gov/pubmed/21306248
__________________________________________________________
ABOUT TRIGGER
TRIGGER is edited by Jim Morrissey and Pierre Neuenschwander, with editorial assistance by Genie Morrissey. It includes Abstracts of Papers in Press, Meeting Announcements, Positions Sought/Available,or any other pertinent item that subscribers may want to share with their colleagues. To submit an item for publication in Trigger, e-mail us. To request or cancel a subscription,or for more information about TRIGGER or the biology of tissue factor and factor VII, visit our web site. You can also contact us by mail: J.H. Morrissey, University of Illinois College of Medicine, 417 Med Sci Bldg MC-714, 506 S. Mathews Ave., Urbana, IL 61801, USA.

Vol. 17, No. 3

noreply@blogger.com (Pierre) — Wed, 02 Feb 2011 00:26:00 +0000

TRIGGER
The Twice-Monthly Electronic Newsletter on the Biology of Tissue Factor, Factor VII and TFPI
Vol. 17, No. 3 February 1, 2011
(The next issue will be on February 15, 2011)
__________________________________________________________
TRIGGER is also available by RSS Feed:
http://feeds.feedburner.com/blogspot/glro
and BLOG:
http://trigger-tf7.blogspot.com/
__________________________________________________________
PAPERS IN PRESS
None submitted for this issue.
__________________________________________________________
RECENT PUBLICATIONS ON TISSUE FACTOR, FACTOR VII, AND TFPI
Papers are culled from NLM MedLine (PubMed). Titles in square brackets indicate that the paper was not published in English. References that lack volume or page numbers are typically electronic pre-publications (E-pubs) ahead of the print publication; if so, the final citation with volume and page numbers may or may not appear in a future issue of Trigger.
THE FOLLOWING LINK WILL TAKE YOU TO THE ENTIRE LIST OF THIS ISSUE'S PUBLICATIONS IN A PUBMED "COLLECTION":
http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/18GT3YuDrhe2hjYJgZwLnGz/

Abe R, Yamashita N, Rochier A, Nixon A, Madri JA, Sumpio BE (2011) Pulsatile To-fro Flow Induces Greater and Sustained Expression of Tissue Factor RNA in HUVEC than Unidirectional Laminar Flow. Am J Physiol Heart Circ Physiol.
http://www.ncbi.nlm.nih.gov/pubmed/21257914

Ando R, Kase S, Ohashi T, Dong Z, Fukuhara J, Kanda A, . . . Ishida S (2011) Tissue factor expression in human pterygium. Mol Vis 17:63-69.
http://www.ncbi.nlm.nih.gov/pubmed/21245964

Ayral Y, Rauch U, Goldin-Lang P, Eisenreich A, Pepke W, Deiner C, . . . Pels K (2011) Prolonged clopidogrel application reduces tissue factor expression after percutaneous coronary intervention in the porcine model. Cardiovasc Revasc Med 12:47-55.
http://www.ncbi.nlm.nih.gov/pubmed/21241972

Beausoleil MS, Schulze EB, Goodale D, Postenka CO, Allan AL (2011) Deletion of the thrombin cleavage domain of osteopontin mediates breast cancer cell adhesion, proteolytic activity, tumorgenicity, and metastasis. BMC Cancer 11:25.
http://www.ncbi.nlm.nih.gov/pubmed/21247495

Berckmans RJ, Sturk A, Schaap MC, Nieuwland R (2011) Cell-derived vesicles exposing coagulant tissue factor in saliva. Blood.
http://www.ncbi.nlm.nih.gov/pubmed/21248061

Brodin E, Vikan T, Hansen JB, Svartberg J (2011) Testosterone, hemostasis, and cardiovascular diseases in men. Semin Thromb Hemost 37:87-94.
http://www.ncbi.nlm.nih.gov/pubmed/21249606

Campello E, Spiezia L, Radu CM, Bulato C, Castelli M, Gavasso S, Simioni P (2011) Endothelial, platelet, and tissue factor-bearing microparticles in cancer patients with and without venous thromboembolism. Thromb Res.
http://www.ncbi.nlm.nih.gov/pubmed/21256535

Chen Z, Huo JR, Zhu HY (2011) Effect of ligustrazine on mice model of hepatic veno-occlusive disease induced by Sedum aizoon. J Gastroenterol Hepatol.
http://www.ncbi.nlm.nih.gov/pubmed/21251065

Cugno M, Castelli R, Mari D, Mozzi E, Zappa MA, Boscolo-Anzoletti M, . . . Mannucci PM (2011) Inflammatory and prothrombotic parameters in normotensive non-diabetic obese women: effect of weight loss obtained by gastric banding. Intern Emerg Med.
http://www.ncbi.nlm.nih.gov/pubmed/21249470

Dabar G, Harmouche C, Jammal M (2011) [Efficacy of recombinant activated factor VII in diffuse alveolar haemorrhage.]. Rev Mal Respir 28:106-111.
http://www.ncbi.nlm.nih.gov/pubmed/21277485

Deloughery EP, Lenfesty B, Deloughery TG (2011) A retrospective case control study of recombinant factor VIIa in patients with intracranial haemorrhage caused by trauma. Br J Haematol.
http://www.ncbi.nlm.nih.gov/pubmed/21275948

Duntas LH, Biondi B (2011) New insights into subclinical hypothyroidism and cardiovascular risk. Semin Thromb Hemost 37:27-34.
http://www.ncbi.nlm.nih.gov/pubmed/21249602

Eckly A, Hechler B, Freund M, Zerr M, Cazenave JP, Lanza F, . . . Gachet C (2011) Mechanisms underlying FeCl(3) -induced arterial thrombosis. J Thromb Haemost.
http://www.ncbi.nlm.nih.gov/pubmed/21261806

Fedorov O, Huber K, Eisenreich A, Filippakopoulos P, King O, Bullock AN, . . . Knapp S (2011) Specific CLK Inhibitors from a Novel Chemotype for Regulation of Alternative Splicing. Chem Biol 18:67-76.
http://www.ncbi.nlm.nih.gov/pubmed/21276940

Fortenberry YM, Cook AB, Church FC (2011) Protein C inhibitor inhibits factor VIIa when bound to tissue factor. J Thromb Haemost.
http://www.ncbi.nlm.nih.gov/pubmed/21251198

Gerrits AJ, Koekman CA, van Haeften TW, Akkerman JW (2011) Increased tissue factor expression in diabetes mellitus type 2-monocytes caused by insulin resistance. J Thromb Haemost.
http://www.ncbi.nlm.nih.gov/pubmed/21251203

Girardi G (2011) Role of tissue factor in pregnancy complications: crosstalk between coagulation and inflammation. Thromb Res 127S3:S43-S46.
http://www.ncbi.nlm.nih.gov/pubmed/21262438

Hammad MA, Abdel-Bakky MS, Walker LA, Ashfaq MK (2011) Oxidized low-density lipoprotein and tissue factor are involved in monocrotaline/lipopolysaccharide-induced hepatotoxicity. Arch Toxicol.
http://www.ncbi.nlm.nih.gov/pubmed/21279329

Holzhauser E, Albrecht C, Zhou Q, Buttler A, Preusch MR, Blessing E, . . . Bea F (2011) Nicotinic acid has anti-atherogenic and anti-inflammatory properties on advanced atherosclerotic lesions independent of its lipid-modifying capabilities Holzhauser et al., Anti-atherogenic properties of nicotinic acid. J Cardiovasc Pharmacol.
http://www.ncbi.nlm.nih.gov/pubmed/21242806

Johansson L, Karpf DM, Hansen L, Pelzer H, Persson E (2011) Activation peptides prolong the murine plasma half-life of human factor VII. Blood.
http://www.ncbi.nlm.nih.gov/pubmed/21252090

Kamat P, Kunde S, Vos M, Vats A, Heffron T, Romero R, Fortenberry JD (2011) Invasive intracranial pressure monitoring is a useful adjunct in the management of severe hepatic encephalopathy associated with pediatric acute liver failure. Pediatr Crit Care Med.
http://www.ncbi.nlm.nih.gov/pubmed/21263362

Kozuma Y, Sawahata Y, Takei Y, Chiba S, Ninomiya H (2011) Procoagulant properties of microparticles released from red blood cells in paroxysmal nocturnal haemoglobinuria. Br J Haematol.
http://www.ncbi.nlm.nih.gov/pubmed/21241275

Krysiak R, Gdula-Dymek A, Okopien B (2010) Hemostatic effects of simvastatin in subjects with impaired fasting glucose. Pharmacol Rep 62:1090-1098.
http://www.ncbi.nlm.nih.gov/pubmed/21273666

Krysiak R, Handzlik G, Okopien B (2010) Hemostatic effects of fenofibrate in patients with mixed dyslipidemia and impaired fasting glucose. Pharmacol Rep 62:1099-1107.
http://www.ncbi.nlm.nih.gov/pubmed/21273667

Lin R, Roychowdhury-Saha M, Black C, Watt AT, Marcusson EG, Freier SM, Edgington TS (2011) Control of RNA processing by a large non-coding RNA over-expressed in carcinomas. FEBS Lett.
http://www.ncbi.nlm.nih.gov/pubmed/21266177

Mitterlechner T, Innerhofer P, Streif W, Lodl M, Danninger T, Klima G, . . . Fries D (2011) PCC, recombinant prothrombin alone or in combination with recombinant FX and FVIIa in dilutional coagulopathy: a porcine model. J Thromb Haemost.
http://www.ncbi.nlm.nih.gov/pubmed/21255250

Pierfranceschi MG, Imberti D, Orlando S, Vallisa D, Michieletti E (2010) Effectiveness of recombinant activated factor VII in haemorragic cancer-related disseminated intravascular coagulation: a case report. Blood Transfus.
http://www.ncbi.nlm.nih.gov/pubmed/21251460

Rondina MT, Schwertz H, Harris ES, Kraemer BF, Campbell RA, Mackman N, . . . Zimmerman GA (2011) The Septic Milieu Triggers Expression of Spliced Tissue Factor mRNA in Human Platelets. J Thromb Haemost.
http://www.ncbi.nlm.nih.gov/pubmed/21255247

Seested T, Appa RS, Christensen EI, Ioannou YA, Krogh TN, Karpf DM, Nielsen HM (2011) In vivo clearance and metabolism of recombinant activated factor VII (rFVIIa) and its complexes with plasma protease inhibitors in the liver. Thromb Res.
http://www.ncbi.nlm.nih.gov/pubmed/21262526

Sen P, Gopalakrishnan R, Kothari H, Keshava S, Clark CA, Esmon CT, . . . Rao LV (2011) Factor VIIa bound to endothelial cell protein C receptor activates protease activated receptor-1 and mediates cell signaling and barrier protection. Blood.
http://www.ncbi.nlm.nih.gov/pubmed/21252088

Solomon D, Kim B, Scultetus A, Arnaud F, Auker C, Freilich D, McCarron R (2011) The effect of rFVIIa on pro- and anti-inflamatory cytokines in serum and cerebrospinal fluid in a swine model of traumatic brain injury. Cytokine.
http://www.ncbi.nlm.nih.gov/pubmed/21251848

Trigg DE, Wood MG, Kouides PA, Kadir RA (2011) Hormonal influences on hemostasis in women. Semin Thromb Hemost 37:77-86.
http://www.ncbi.nlm.nih.gov/pubmed/21249605

van den Besselaar AM, Witteveen E, Tripodi A (2011) Calibration of Combined Thromboplastins with the International Standard for Thromboplastin, Rabbit, Plain. J Thromb Haemost.
http://www.ncbi.nlm.nih.gov/pubmed/21261807

Wang CH, Li F, Hiller S, Kim HS, Maeda N, Smithies O, Takahashi N (2011) A modest decrease in endothelial NOS in mice comparable to that associated with human NOS3 variants exacerbates diabetic nephropathy. Proc Natl Acad Sci U S A.
http://www.ncbi.nlm.nih.gov/pubmed/21245338

Yamashita A, Asada Y (2011) A rabbit model of thrombosis on atherosclerotic lesions. J Biomed Biotechnol 2011:424929.
http://www.ncbi.nlm.nih.gov/pubmed/21253503

Zwicker JI, Trenor CC, 3rd, Furie BC, Furie B (2011) Tissue Factor-Bearing Microparticles and Thrombus Formation. Arterioscler Thromb Vasc Biol.
http://www.ncbi.nlm.nih.gov/pubmed/21252066
__________________________________________________________
ABOUT TRIGGER
TRIGGER is edited by Jim Morrissey and Pierre Neuenschwander, with editorial assistance by Genie Morrissey. It includes Abstracts of Papers in Press, Meeting Announcements, Positions Sought/Available,or any other pertinent item that subscribers may want to share with their colleagues. To submit an item for publication in Trigger, e-mail us. To request or cancel a subscription,or for more information about TRIGGER or the biology of tissue factor and factor VII, visit our web site. You can also contact us by mail: J.H. Morrissey, University of Illinois College of Medicine, 417 Med Sci Bldg MC-714, 506 S. Mathews Ave., Urbana, IL 61801, USA.