Get To Know About Brain Tumor

What You Need To Know About Brain

noreply@blogger.com (MH) — Sat, 16 Aug 2008 15:15:00 +0000

The brain is a soft, spongy mass of tissue. It is protected by the bones of the skull and three thin membranes called meninges. Watery fluid called cerebrospinal fluid cushions the brain. This fluid flows through spaces between the meninges and through spaces within the brain called ventricles.

Illustration shows the skull, spinal cord, brain, meninges, ventricles, the fluid between the meninges, and the fluid in the ventricles.
The brain and nearby structures

A network of nerves carries messages back and forth between the brain and the rest of the body. Some nerves go directly from the brain to the eyes, ears, and other parts of the head. Other nerves run through the spinal cord to connect the brain with the other parts of the body. Within the brain and spinal cord, glial cells surround nerve cells and hold them in place.

The brain directs the things we choose to do (like walking and talking) and the things our body does without thinking (like breathing). The brain is also in charge of our senses (sight, hearing, touch, taste, and smell), memory, emotions, and personality.

The three major parts of the brain control different activities:

Cerebrum—The cerebrum is the largest part of the brain. It is at the top of the brain. It uses information from our senses to tell us what is going on around us and tells our body how to respond. It controls reading, thinking, learning, speech, and emotions.

The cerebrum is divided into the left and right cerebral hemispheres, which control separate activities. The right hemisphere controls the muscles on the left side of the body. The left hemisphere controls the muscles on the right side of the body.

Cerebellum—The cerebellum is under the cerebrum at the back of the brain. The cerebellum controls balance and complex actions like walking and talking.

Brain Stem—The brain stem connects the brain with the spinal cord. It controls hunger and thirst. It also controls breathing, body temperature, blood pressure, and other basic body functions.

Brain Structures and Functions

noreply@blogger.com (MH) — Sat, 16 Aug 2008 14:00:00 +0000

Cerebrum
Cerebellum
Limbic System
Brain Stem

The nervous system is your body's decision and communication center. The central nervous system (CNS) is made of the brain and the spinal cord and the peripheral nervous system (PNS) is made of nerves. Together they control every part of your daily life, from breathing and blinking to helping you memorize facts for a test. Nerves reach from your brain to your face, ears, eyes, nose, and spinal cord... and from the spinal cord to the rest of your body. Sensory nerves gather information from the environment, send that info to the spinal cord, which then speed the message to the brain. The brain then makes sense of that message and fires off a response. Motor neurons deliver the instructions from the brain to the rest of your body. The spinal cord, made of a bundle of nerves running up and down the spine, is similar to a superhighway, speeding messages to and from the brain at every second.

The brain is made of three main parts: the forebrain, midbrain, and hindbrain. The forebrain consists of the cerebrum, thalamus, and hypothalamus (part of the limbic system). The midbrain consists of the tectum and tegmentum. The hindbrain is made of the cerebellum, pons and medulla. Often the midbrain, pons, and medulla are referred to together as the brainstem.

The Cerebrum:The cerebrum or cortex is the largest part of the human brain, associated with higher brain function such as thought and action. The cerebral cortex is divided into four sections, called "lobes": the frontal lobe, parietal lobe, occipital lobe, and temporal lobe. Here is a visual representation of the cortex:

What do each of these lobes do?

Frontal Lobe- associated with reasoning, planning, parts of speech, movement, emotions, and problem solving
Parietal Lobe- associated with movement, orientation, recognition, perception of stimuli
Occipital Lobe- associated with visual processing
Temporal Lobe- associated with perception and recognition of auditory stimuli, memory, and speech

Note that the cerebral cortex is highly wrinkled. Essentially this makes the brain more efficient, because it can increase the surface area of the brain and the amount of neurons within it.

A deep furrow divides the cerebrum into two halves, known as the left and right hemispheres. The two hemispheres look mostly symmetrical yet it has been shown that each side functions slightly different than the other. Sometimes the right hemisphere is associated with creativity and the left hemispheres is associated with logic abilities. The corpus callosum is a bundle of axons which connects these two hemispheres.

Nerve cells make up the gray surface of the cerebrum which is a little thicker than your thumb. White nerve fibers underneath carry signals between the nerve cells and other parts of the brain and body.

The neocortex occupies the bulk of the cerebrum. This is a six-layered structure of the cerebral cortex which is only found in mammals. It is thought that the neocortex is a recently evolved structure, and is associated with "higher" information processing by more fully evolved animals (such as humans, primates, dolphins, etc). For more information about the neocortex, click here.

The cerebellum, or "little brain", is similar to the cerebrum in that it has two hemispheres and has a highly folded surface or cortex. This structure is associated with regulation and coordination of movement, posture, and balance.

The cerebellum is assumed to be much older than the cerebrum, evolutionarily. What do I mean by this? In other words, animals which scientists assume to have evolved prior to humans, for example reptiles, do have developed cerebellums. However, reptiles do not have neocortex. Go here for more discussion of the neocortex or go to the following web site for a more detailed look at evolution of brain structures and intelligence: "Ask the Experts": Evolution and Intelligence

The limbic system, often referred to as the "emotional brain", is found buried within the cerebrum. Like the cerebellum, evolutionarily the structure is rather old.

This system contains the thalamus, hypothalamus, amygdala, and hippocampus. Here is a visual representation of this system, from a midsagittal view of the human brain:

Click on the words to learn what these structures do:

Thalamus
Hypothalamus
Amygdala
Hippocampus

Underneath the limbic system is the brain stem. This structure is responsible for basic vital life functions such as breathing, heartbeat, and blood pressure. Scientists say that this is the "simplest" part of human brains because animals' entire brains, such as reptiles (who appear early on the evolutionary scale) resemble our brain stem. Look at a good example of this here.

The brain stem is made of the midbrain, pons, and medulla. Click on the words to learn what these structures do:

Midbrain
Pons
Medulla

Upon completing the map, it was becoming clear to researchers that each side of the brain had a characteristic way that it both interpreted the world and reacted to it. The chart below will help illustrate the characteristics which are known to reside on each side of our brains.

LEFT BRAIN FUNCTIONS	RIGHT BRAIN FUNCTIONS
uses logic detail oriented facts rule words and language present and past math and science can comprehend knowing acknowledges order/pattern perception knows object name reality based forms strategies practical safe	uses feeling "big picture" oriented imagination rules symbols and images present and future philosophy & religion can "get it" (i.e. meaning) believes appreciates spatial perception knows object function fantasy based presents possibilities impetuous risk taking

Brain Tumor : Defination and Description

noreply@blogger.com (MH) — Sat, 16 Aug 2008 13:21:00 +0000

Astrocytoma

Definition
Astrocytoma is a tumor that arises from astrocytes, star-shaped cells that play a supportive role in the brain.

Description
The brain acts as a computer that controls all of the functions of the body. It stores information, memories, and with the use of hormones and electrical impulses, regulates and sends instructions to the rest of the body. Because of the brain’s importance, cancers in the brain can affect many of the body’s functions. The location of a tumor within the brain determines which effects it will have. Astrocytomas may occur in the cerebrum, the site of thought and language, the cerebellum, the area responsible for movement and muscle co-ordination, or the brainstem, the location that regulates critical activities like breathing and heartbeat. Childhood astrocytomas are most commonly located in the cerebellum, while adults usually develop astrocytoma in the cerebrum.

Astrocytomas rarely metastasize (spread) outside the brain to other parts of the body; however, they may grow and spread within the brain. As there is no extra room in the skull, the presence of a brain tumor causes an increase in intracranial (within the skull) pressure, resulting in headaches and possibly affecting normal brain function by compressing delicate brain tissue. Astrocytomas are a type of glioma, a tumor of glial cells (specialized cells that give physical support and electrical insulation between neurons). They are sometimes called gliomas, anaplastic astrocytomas, or glioblastoma multiforme. Oligoastrocytomas are a type of mixed glioma similar to astrocytomas. They usually contain cells that originate from oligodendrocytes as well as astrocytes, and are usually low grade (grading is an estimate of the tumor’s malignancy and aggressiveness; lower-grade tumors require less drastic therapy than high-grade tumors).

Brain and Central Nervous System Tumors

noreply@blogger.com (MH) — Sat, 16 Aug 2008 13:21:00 +0000

Definition
Like all other parts of the body, the brain and central nervous system are made up of cells that ordinarily grow and divide to create new cells as needed. This is usually an orderly process; but when cells lose their ability to grow normally or to die off naturally, they divide too often and produce tumors that are made up of these extra cells.

Description
The brain and spinal cord together comprise what is known as the central nervous system (CNS). Like all tumors in the body, CNS tumors are either benign or malignant. Benign tumors are called non-cancerous because they have precise borders, are not invasive, and the cells that make up the growth are similar to other normal cells and grow relatively slowly. However, benign CNS tumors can press on a specific region of the spinal cord or brain and, thereby, cause symptoms. However, when such a benign tumor develops in an area that interferes with essential nervous system functioning, it is treated as malignant.

Malignant, or cancerous, tumors of the central nervous system are likely to be fast-growing, are invasive into surrounding healthy tissue, and the cells are very different from normal cells. These tumors can create a life-threatening situation by stopping vital functions of the brain. Some cancerous CNS tumors do not put out roots nor do they grow rapidly. These tumors are described as being encapsulated. Another way that brain and central nervous system tumors are classified is by site of origin. Those that actually develop in the brain or spinal cord are called primary CNS tumors. Metastasis to the brain or spinal cord is, for the most part, a one-way street, meaning these tumors almost never metastasize to other areas in the body. The tumors that develop elsewhere in the body and metastasize, or spread, to the central nervous system are considered to be secondary CNS tumors. Such metastatic cells do not resemble other CNS cells. Instead, they have the same appearance as the cancer cells at the original cancer site elsewhere in the body.

Frequently observed signs of a brain tumor are the following:

severe headaches
an ataxic, or stumbling, gait
nausea and vomiting
lack of coordination
unusual drowsiness
weakness or loss of feelings in the arms and legs
changes in personality or memory
changes in speech
changes in vision or abnormal eye movements
seizures

Approximately 1 1/2% of all diagnosed cancers are CNS cancers, and they account for about 2 1/2% of all cancer deaths. The American Cancer Society (ACS) estimates that in 2001 17,200 malignant tumors of the brain or spinal cord will be diagnosed in adults and children in the United States. Of those people diagnosed, ACS projects that 13,100 will die from malignant CNS tumors.

Brain and Central nervous system tumors

Gliomas

Astrocytomas
Brain stem gliomas
Ependymomas
Oligodendrogliomas

Non-glial tumors

Medulloblastomas
Meningiomas
Schwannomas
Craniopharyngiomas
Germinomas
Pineal region tumors

Typically, diagnosis of CNS tumor is made by a physician who does a complete physical examination, including a family history and neurological examination. Computerized tomography (CT) scans, magnetic resonance imaging (MRI) scans, skull x rays, brain scans, angiograms, or myelograms are among the means of visualizing the brain or spinal cord to search for tumors.

General categories of treatment methods for CNS tumors include surgery, radiation therapy, and chemotherapy, with surgery being the single most commonly used therapy. Steroids are usually given prior to treatment to decrease swelling, and anti-convulsant drugs may be given to prevent seizures.

Types of Cancer

noreply@blogger.com (MH) — Sat, 16 Aug 2008 13:20:00 +0000

Primary brain tumors are also classified by their site of origin. Gliomas, occurring in the glial, or supportive tissues around the brain, are the most common. Gliomas are further broken down into the following variations:

Astrocytomas are named for the star-shaped, small cells that they are comprised of. Children may develop these in their brain stem, cerebrum, or cerebellum, while adults commonly develop them in the cerebrum.
Brain-stem gliomas are usually astrocytomas that originate in the bottom, stem-like portion of the brain. Because this area controls many essential bodily functions, such tumors often cannot be removed.
Ependymomas occur in the linings of the four brain ventricles, or chambers, or along the spinal cord. These are more common in children.
Oligodendrogliomas are very rare and, when seen, are usually found in middle-aged adults. They grow slowly and ordinarily do not invade surrounding brain or spinal cord tissue. They originate in the cells responsible for the manufacture of myelin, a fatty covering for nerve tissue.

Other CNS tumors do not originate in glial tissue. Among these are:

Medulloblastomas, tumors of the cerebellum, are most common in male children. Studies have shown these to originate in primitive nerve cells that normally would have disappeared soon after birth.
Meningiomas are usually benign. They develop in the meninges, or brain linings, and grow very slowly. Because of this slow growth, they may go undetected for years. Meningiomas are more common in women between the ages of 30 and 50.
Schwannomas are also benign tumors, specific to the myelin-producing cells (Schwann cells) for the acoustic, or hearing, nerve. These, too, are more common in women than men.
Craniopharyngiomas are usually benign, but because of their location near the pituitary gland and hypothalmus, they can easily affect vital functions and are therefore treated as if malignant. They occur more frequently in children and teenagers.

Fig. 1. Grade Ⅲ craniopharyngioma. T1-weighted coronal-enhanced MR image showing the intracisternal tumor extending to the lower half of the third ventricle.
Fig. 2. A： Grade Ⅳ craniopharyngioma. The patient had acute disturbance of consciousness. Emergency cranial T1-weighted enhanced MR image illustrating that the tumor grew upwards into the upper part of the third ventricle and the right lateral ventricle was slightly dilated. Patient’s condition improved after ventriculoperitoneal shunt. The removed tissues confirmed that the patient had craniopharyngioma. B: The patient well recovered and MRI after 3 years showed no recurrence.
Fig. 3. Grade Ⅴ craniopharyngioma. T1-weighted enhanced magnetic resonance image showing that the tumor manifested itself as an uneven signal and multiform or polycystic form, and the tumor extended into the right lateral ventricle and the brain parenchyma through the interventricular foramen.

Germinomas, or germ cell tumors, develop from primitive sex cells called germ cells.
Pineal-region tumors originate in the area near the pineal gland, a small central brain gland that secretes melatonin, a brain chemical. These can be either fastgrowing pineoblastoma, or slow-growing pineocytoma.

KEY TERMS
Angiogram—A diagnostic test that makes it possible for blood vessels to be seen on film by filling them with a contrast substance or dye that appears on x rays.

Anti-convulsant drugs—A group of medications used in the treatment of seizures.
Brain scan—A general term that can include CT scans, MRIs, seldom-used radionuclide scanning (use of radioactive isotopes), or ultrasounds.

Computerized tomography (CT) scan—The combined use of a computer and x rays that are passed through the body to produce clear, cross-sectional images.

Magnetic resonance imaging (MRI)—An imaging technique that produces good cross-sectional images without x rays or other radiation sources.

Myelogram—X-ray examination of the spinal cord after injection of a contrast substance or dye that shows up on x rays.

Neurological exam—A physical examination that focuses on the patient’s nerves, reflexes, motor and sensory functions, and muscle strength and tone.

Seizures—Sudden, uncontrolled electrical activity in the brain resulting in characteristic twitching, or spastic, movements that may be accompanied by loss of consciousness.

Steroids—A group of drugs that are similar to the hormones produced by the cortex of the adrenal gland.

Ventricles of the brain—The four fluid-filled chambers, or cavities, found in the two cerebral hemispheres of the brain, at the center of the brain, and between the brain stem and cerebellum, and linked by channels, or ducts, allowing cerebral fluid to circulate through them.

Causes and Symptoms

noreply@blogger.com (MH) — Fri, 15 Aug 2008 17:47:00 +0000

The cause of astrocytoma is not known. Brain cancer may occasionally be caused by previous radiation treatments; however, x rays are not believed to play a role. As of 2001, studies have indicated that the moderate use of handheld cellular phones does not cause brain cancer; ongoing research will determine if long-term cellular phone use causes an increase in cancer incidence. Some studies suggest that brain tumors may occur more frequently in people who have occupational exposure to certain chemicals, including some pesticides, formaldehyde, vinyl chloride, phenols, acrylonitrile, Nnitroso compounds, polycyclic aromatic hydrocarbons, lubricating oils, and organic solvents. The greatest risk is associated with exposure before birth or during infancy.

There is a slightly higher incidence of astrocytoma in the siblings and parents of people with this tumor; however, only one type of astrocytoma is known to have a genetic cause. The rare subependymal giant cell astrocytoma occurs in conjunction with tuberous sclerosis, a hereditary disorder.

A wide variety of symptoms develop as a result of astrocytoma, including the following:

headache
nausea and vomiting
neck stiffness or pain
dizziness
seizures
unsteadiness in walking or unusual gait
lack of coordination, decreased muscle control
visual problems such as blurring, double vision, or loss of peripheral vision
weakness in arms or legs
speech impairment
altered behavior
loss of appetite

Because there are several different types of astrocytoma, not all patients will show the same symptoms. The location of the tumor within the brain will determine which symptoms a patient will experience. Because the tumor causes an increase in intracranial pressure, most people with astrocytoma will develop headaches and nausea and vomiting.

Diagnosis

noreply@blogger.com (MH) — Fri, 15 Aug 2008 17:42:00 +0000

In the first stage of diagnosis the doctor will take a history of symptoms and perform a basic neurological exam, including an eye exam and tests of vision, balance, coordination and mental status. The doctor will then require a computerized tomography (CT) scan and magnetic resonance imaging (MRI) of the patient’s brain. During a CT scan, x rays of the patient’s brain are taken from many different directions; these are combined by a computer, producing a cross-sectional image of the brain. For an MRI, the patient relaxes in a tunnel-like instrument while the brain is subjected to changes of magnetic field. An image is produced based on the behavior of the brain’s water molecules in response to the magnetic fields. A special dye may be injected into a vein before these scans to provide contrast and make tumors easier to identify.

If a tumor is found it will be necessary for a neurosurgeon to perform a biopsy on it. This simply involves the removal of a small amount of tumor tissue, which is then sent to a neuropathologist for examination and staging. The biopsy may take place before surgical removal of the tumor or the sample may be taken during surgery. Staging of the tumor sample is a method of classification that helps the doctor to determine the severity of the astrocytoma and to decide on the best treatment options. The neuropathologist stages the tumor by looking for atypical cells, the growth of new blood vessels, and for indicators of cell division called mitotic figures.

Treatments Term, Clinical Staging and Prognosi

noreply@blogger.com (MH) — Fri, 15 Aug 2008 17:33:00 +0000

Treatment of astrocytoma will involve a neurosurgeon to remove the tumor, a neuropathologist to examine the tumor sample, and an oncologist to monitor the patient’s health and coordinate radiation therapy and chemotherapy if necessary. Nurses and radiation therapists will also play a role. After treatment, the patient may be followed up by a neurologist

The World Health Organization (WHO) system is the most common; it has four grades of increasing severity based on the appearance of the astrocytoma cells. Other methods of staging correspond fairly closely to the WHO system. Grades I and II are sometimes grouped together and referred to as low-grade astrocytomas. Over time, tumors may progress from a low-grade form with a relatively good prognosis to a higher grade form and poorer prognosis. Additionally, tumors may recur at a higher grade.

There are several different systems for staging astrocytomas.

Grade I Pilocytic Astrocytoma
This is also sometimes referred to as juvenile astrocytoma because it occurs more frequently in children than adults. Under a microscope, the astrocytes are thin and elongated, and known as pilocytes. They are accompanied by Rosenthal fibers. The tumor mass does not invade surrounding tissues and is sometimes enclosed in a cyst. In children, pilocytic astrocytoma often occurs in the cerebellum, but may also occur in the cerebrum.

Treatment of this grade depends on the patient’s age and the location of the tumor. Surgery is the preferred treatment for this type of astrocytoma; it is performed by a procedure known as a craniotomy. An incision is made in the skin and an opening is made in the skull. After the tumor is removed, the bone is normally replaced and the incision closed. The neurosurgeon may also insert a shunt (drainage system) to relieve intracranial pressure; this involves inserting a catheter into a cavity inside the brain called a ventricle, then threading the other end under the skin to a drainage area where the fluid is absorbed. If the tumor can be completely surgically removed, the patient may not need further therapy and may be monitored only for recurrence.

If the tumor cannot be completely removed, patients may be given chemotherapy as well. If the tumor is not completely resected or if it continues to grow after chemotherapy, radiation therapy may be necessary. Radiation therapy is not normally given to children under the age of three in order to prevent permanent damage to the child’s healthy brain tissue. Radiation treatment may cause swelling in the brain; steroids may be prescribed to reduce the swelling. The best indicator for prognosis is complete removal of the tumor. With complete tumor removal, 80% of patients are alive ten years later. Location of the tumor in the cerebellum also suggests a better prognosis than other locations.

Grade II Low-Grade Diffuse Astrocytoma
These astrocytomas spread out and invade surrounding brain tissues but grow very slowly. Under the microscope, Grade II astrocytomas may occur anywhere in the brain, in the cerebellum and brain stem, or in the cerebrum, including the optic pathways. Genetic studies indicate that mutations of the tumor suppressor gene p53 occur frequently in these tumors. Surgical removal of the tumor is the first choice for treatment, but it may not be possible due the tumor’s location. Surgery is usually followed by radiation.

Patients under 35 years of age have a better prognosis than older patients; in older patients, low-grade tumors progress to higher grades more rapidly. Overall median survival is four to five years. Pleimorphic xanthoastrocytoma, a tumor originating in cells of a mixture of glial and neuronal origin, is often considered a grade II astrocytoma. It is relatively benign and treated only with surgery.

Grade III Anaplastic Astrocytoma
Anaplastic astrocytoma occurs most frequently in people aged 50 to 60. The term anaplastic means that the cells are not differentiated; they have the appearance of immature cells and cannot perform their proper functions. Researchers believe this is due to a gradual accumulation of genetic alterations in these cells. These tumor cells invade surrounding healthy brain tissue. Anaplastic astrocytomas may be inoperable because of their location and their infiltration into normal tissue; in this case radiation therapy is recommended. Chemotherapy may include various combinations of alkylating agents and other drugs, including carmustine, cisplatin, lomustine, procarbazine and vincristine.

These tumors tend to recur more frequently than grade I and II tumors. Following treatment, median survival is 12 to 18 months. The five-year survival rate for these patients is approximately 10% to 35%.

Grade IV Glioblastoma Multiforme
Glioblastoma Multiforme (GBM) is the most common primary brain tumor in adults. These tumors aggressively invade adjacent tissue and may even spread throughout the central nervous system. They frequently occur in the frontal lobes of the cerebrum.

KEY TERMS
Anaplastic—Undifferentiated, appearing to have an immature cell type.
Biopsy—A sample of tissue taken from the tumor.
Glioma—A tumor of the brain’s glial cells.
Primary tumor—An original tumor, not a metastatic tumor resulting from cancer’s spread. fibrous structures are present.

QUESTIONS TO ASK THE DOCTOR

noreply@blogger.com (MH) — Fri, 15 Aug 2008 17:26:00 +0000

Where inside my brain is the cancer located and where will it spread?
What types of treatment are recommended?
What are the possible side effects of this treatment?
How can the side effects be minimized?
Am I eligible for any clinical trials?
Are there any alternatives to this treatment?
What are the chances that the cancer will return?
Will this cause any disabilities?
How will this affect my daily life?

Tumor biopsies may show large areas of necrosis, or dead cells, surrounded by areas of rampant growth. There may also be a mixture of cell types within the biopsy. Genetic studies show that a number of different types of mutations can take place in genes for tumor suppressor p53 and other proteins that play a role in controlling the normal growth of cells.

Often GBM cannot be entirely surgically removed because it affects large areas of the brain. Radiation therapy will be given regardless of whether surgery is possible, except to very young children. Conventional radiation may be performed, but more specialized types, such as stereotactic radiosurgery, which uses imaging and a computer to treat the tumor very precisely, or interstitial radiation, which delivers radiation by placing radioactive material directly on the tumor, may also be used. Chemotherapy will follow radiation; it may include carmustine, lomustine, procarbazine, and vincristine.

GBM is most common in patients over 50 years of age and rarely occurs in patients under 30. Increasing age is associated with a poorer prognosis. Median survivalis 9 to 11 months following treatment. Fewer than 5% of patients are alive five years later. Because of the poor prognosis of GBM, it is treated more aggressively than low-grade astrocytomas; many clinical trials take place to test new treatments.

Alternative and complementary therapies
While no specific alternative therapies have become popular for this particular type of brain cancer, patients interested in pursuing complementary therapies should discuss the idea with their doctor. A doctor may be able to provide information about the efficacy of certain techniques and whether they may interfere with conventional treatment.

Coping With Cancer Treatment

noreply@blogger.com (MH) — Fri, 15 Aug 2008 17:24:00 +0000

Patients may experience unpleasant side effects due to their treatment. Patients should discuss any side effects they experience with their doctors; occasionally an effect may be unexpected or dangerous and dosages may need to be adjusted. Doctors can help alleviate nausea with antinausea medications and may prescribe antidepressants to help the patient deal with the cancer on a psychological level. Joining support groups will also help patients deal with the psychological effects of treatment. Cancer survivors can help provide encouragement and offer advice for coping with cancer on a day-to-day basis.

Clinical trials

noreply@blogger.com (MH) — Fri, 15 Aug 2008 17:23:00 +0000

Clinical trials are an important treatment possibility, especially for patients with tumors that are inoperable or do not respond well to treatment. Participation in clinical trials also gives patients an opportunity to make contributions to the search to find a cure for their cancer. A wide variety of clinical trials are available, particularly for the higher-grade astrocytomas. Trials for higher-grade astrocytomas may test new drugs, new combinations of drugs, drug implants, and higher doses of drugs, possibly in combination with different methods of radiation therapy. Some studies may examine the use of gene therapy or immune therapy, including vaccines.

Trials for lower-grade astrocytomas focus on finding chemotherapy that causes fewer side effects. Some studies may also feature new combinations of drugs while others may attempt to treat the tumor by using lower dosages of drugs spread out over a longer period of time.

Prevention

noreply@blogger.com (MH) — Fri, 15 Aug 2008 17:20:00 +0000

Currently, scientists do not know what causes the majority of brain cancers. There may be a slight genetic predisposition, as family members of astrocytoma patients have a slightly increased incidence of the disease.

Clinical studies show that a large number of genetic alterations take place in the higher grade astrocytomas; although this helps to explain what is going wrong in the cells, it does not explain what is causing these genetic mutations to take place.

While it is known that ionizing radiation can cause brain tumors, most people are not exposed to this type of radiation unless they are being treated for cancer. Ongoing studies are examining the long-term risks of other types of radiation, but as of 2001, neither x rays, electromagnetic fields, or cellular phones appear to increase the likelihood of brain cancers. Although evidence is not yet conclusive, some studies suggest that some brain tumors may be caused by environmental exposure to certain organic chemicals.

Exposure is most harmful to the developing fetus and infants, so pregnant women may wish to consider whether they have any occupational exposure to organic chemicals. Parents of infants should be aware of pesticides and any other potentially harmful chemical their child could come into contact with.

Additionally there is some evidence that supplements containing vitamins A, C, E, and folate may have a protective effect when taken during pregnancy. The children of women who take these supplements during pregnancy are half as likely to develop brain tumors before age five.

Special Concerns

noreply@blogger.com (MH) — Fri, 15 Aug 2008 17:19:00 +0000

Children who develop astrocytoma should be monitored regularly by their physicians to ensure that the tumor does not recur. A follow-up schedule should be discussed with the doctor; the child may be examined twice a year initially, then tested annually afterwards. In addition to the possibility of recurrence, other health problems due to treatment may arise in the child. The child may have lower levels of growth hormone or thyroid hormone or delayed growth as a result of radiation.

There may also be decreased intellectual capacity or learning or physical disabilities that can be detected during follow-up. Parents can then arrange for rehabilitation or special education for their child.

Adults may also experience permanent negative effects as a result of their treatment. Radiation damage to healthy tissue may occasionally cause delayed effects such as decreased intellect, impaired memory, changes in personality, and confusion. These types of side effects should be reported to a health professional; the patient can be referred to rehabilitation specialists who can help with regaining abilities.

Brain Tumor Surgery

noreply@blogger.com (MH) — Thu, 14 Aug 2008 16:06:00 +0000