tag:blogger.com,1999:blog-105553072024-09-16T13:04:45.446-05:00Chromatin Biology and EpigeneticsA blog focusing on chromatin biology and its impact on many aspects of cell function. Histone modifications, chromatin remodeling, epigenetics, etc.Jim Bonehttp://www.blogger.com/profile/01036355726241695306noreply@blogger.comBlogger5125tag:blogger.com,1999:blog-10555307.post-1158805031886393752006-09-20T21:14:00.000-05:002006-09-20T21:17:11.896-05:00Structure determined for key molecular complex involved in long-term gene storageOriginal URL: http://www.eurekalert.org/pub_releases/2006-09/twi-sdf_1091706.phpStructure determined for key molecular complex involved in long-term gene storage Genome-management system seen as a natural protection against cancer PHILADELPHIA – Around the home, regularly used tools are generally kept close at hand: a can opener in a kitchen drawer, a broom in the hall closet. Less frequently Jim Bonehttp://www.blogger.com/profile/01036355726241695306noreply@blogger.com0tag:blogger.com,1999:blog-10555307.post-1115847197969672692005-05-11T16:31:00.000-05:002005-05-11T16:33:17.976-05:00A novel chromatin immunoprecipitation and array (CIA) analysis identifies a 460-kb CENP-A-binding neocentromere DNA.Lo AW, Magliano DJ, Sibson MC, Kalitsis P, Craig JM, and Choo KH The Murdoch Childrens Research Institute, Royal Children's Hospital, Melbourne, Victoria, Australia 3052.The estrogen receptor alpha (ERalpha) regulates gene expression by either direct binding to estrogen response elements or indirect tethering to other transcription factors on promoter targets. To identify these promoter sequencesJim Bonehttp://www.blogger.com/profile/01036355726241695306noreply@blogger.com0tag:blogger.com,1999:blog-10555307.post-1114550101708078102005-04-26T16:09:00.000-05:002005-04-26T16:15:01.710-05:00Sir2 and the acetyltransferase, Pat, regulate the archael chromatin protein, Alba.Marsh VL, Peak-Chew SY, and Bell SD Medical Research Council Cancer Cell Unit, Cambridge CB2 2XZ. The DNA binding affinity of Alba, a chromatin protein of the archaeon Sulfolobus solfataricus P2, is regulated by acetylation of lysine 16. Here we identify an acetyl transferase that specifically acetylates Alba on this residue. The effect of acetylation is to lower the affinity of Alba for Jim Bonehttp://www.blogger.com/profile/01036355726241695306noreply@blogger.com0tag:blogger.com,1999:blog-10555307.post-1114549093627839802005-04-26T15:52:00.000-05:002005-04-26T16:19:36.190-05:00Regulated chromatin domain comprising cluster of co-expressed genes in Drosophila melanogaster.Kalmykova AI, Nurminsky DI, Ryzhov DV, and Shevelyov YYDepartment of Molecular Genetics of Cell, Institute of Molecular Genetics, Russian Academy of Sciences Moscow 123182, Russia.Recently, the phenomenon of clustering of co-expressed genes on chromosomes was discovered in eukaryotes. To explore the hypothesis that genes within clusters occupy shared chromatin domains, we performed a detailed Jim Bonehttp://www.blogger.com/profile/01036355726241695306noreply@blogger.com0tag:blogger.com,1999:blog-10555307.post-1107275995852854362005-02-01T11:27:00.000-05:002005-02-02T13:33:41.923-05:00Chd1 protein links histone methylation and acetylationNew paper in Nature identifies a new function for yeast chromodomain protein Chd1p, namely recognition and binding of histones methylated at lysine 4. Chd1 was identified as a component of the SAGA andSLIK complexes, recruiting SAGA and SLIK to chromatin containing methyl Lys4 H3. Using biotinylated peptides corresp. to the N-term tail of H3, they were able to pull down Chd1.
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