Current R&D of Pharmaceutical

Agriflu for influenza

Sat, 28 Nov 2009 13:07:28 +0000

The U.S. Food and Drug Administration approved Agriflu for people ages 18 years and older to prevent disease caused by influenza virus subtypes A and B

Link:http://www.medicalnewstoday.com/articles/172405.php

Source:Medical News Today

Imatinib for acute lymphoblastic leukemia

Sat, 28 Nov 2009 13:05:13 +0000

Results of a phase two clinical trial published October 5th in the Journal of Clinical Oncology show that adding continuous daily doses of a targeted drug called imatinib mesylate to regular chemotherapy more than doubled three-year survival rates for children with a high risk type of blood cancer called Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL).

Link:http://www.sciencedaily.com/releases/2009/10/091006173548.htm

Source:ScienceDaily

Omacetaxine for chronic myeloid leukemia

Fri, 27 Nov 2009 22:34:00 +0000

The European Medicines Agency ("EMEA") has determined that the Marketing Authorization Application ("MAA") for omacetaxine mepesuccinate for the treatment of chronic myeloid leukemia (CML) patients who have failed treatment with imatinib and who have developed the Bcr-Abl T315I mutation is valid. Validation of the MAA indicates that ChemGenex’s application, submitted on 29 October 2009, is complete and the review process has begun.

Omacetaxine is a first-in-class cetaxine with demonstrated clinical activity as a single agent in a range of hematological malignancies. Omacetaxine has a novel mechanism of action, specifically binding to the ribosomal A-site cleft and inhibiting protein translation of short-lived oncoproteins that are upregulated in leukemic cells (particularly Cyclin-D1, Mcl-1 and c-Myc).

Link:http://www.chemgenex.com/wt/page/pr_1259276405

Source:ChemGenex

Telavancin for nosocomial pneumonia

Fri, 27 Nov 2009 22:30:58 +0000

A Complete Response letter from the U.S. Food and Drug Administration (FDA) related to the telavancin New Drug Application (NDA) for the treatment of nosocomial pneumonia (NP) was received.

Telavancin is a bactericidal, once-daily injectable investigational antibiotic for the treatment of NP caused by Gram-positive bacteria such as methicillin-resistant Staphylococcus aureus (MRSA).

Link:http://files.shareholder.com/downloads/THERA/723486598x0x334369/107ba636-2b50-4a77-a55e-c0735d21af02/TLV_Complete_Response_NP_Press_Release_Final_2009Nov27.pdf

Source:Theravance

Lu AE58054 for Alzheimer's disease

Fri, 27 Nov 2009 14:43:57 +0000

Danish pharmaceutical group Lundbeck said on Friday it would start clinical phase II trials with drug candidate Lu AE58054 as augmentation treatment in Alzheimer's disease.

Link:http://www.reuters.com/article/financialsSector/idUSDKT00475220091127

Source:Reuters

Asthma for H1N1 influenza

Fri, 27 Nov 2009 14:42:22 +0000

Children with asthma are at greater risk to develop serious symptoms from H1N1 (swine) flu than from seasonal flu, according to a new study.

According to the Centers for Disease Control and Prevention (CDC) a new Canadian study found that children hospitalized with H1N1 were more likely to have asthma (22%) compared to children hospitalized with seasonal flu (6%).

Link:http://www.medicalnewstoday.com/articles/172286.php

Source:Medical News Today

Prevalence for diabetes

Fri, 27 Nov 2009 09:52:45 +0000

In the next 25 years, the number of Americans living with diabetes will nearly double, increasing from 23.7 million in 2009 to 44.1 million in 2034. Over the same period, spending on diabetes will almost triple, rising from $113 billion to $336 billion, even with no increase in the prevalence of obesity.
It is reported in the December issue of Diabetes Care.
Link:http://www.eurekalert.org/pub_releases/2009-11/uocm-dct111909.php
Source:EurekAlert

Cetuximab for colorectal cancer

Fri, 27 Nov 2009 09:50:10 +0000

An article published Online First in The Lancet Oncology reports that adding cetuximab to neoadjuvant chemotherapy can shrink tumours and lead to increased potentially curative surgery in patients who have colorectal cancer with inoperable metastatic liver lesions.
Link:http://www.medicalnewstoday.com/articles/172205.php
Source:Medical News Today

Unexpressed anger for multiple sclerosis

Fri, 27 Nov 2009 09:47:34 +0000

People with Multiple Sclerosis (MS) feel more than twice as much withheld anger as the general population and this could have an adverse effect on their relationships and health, according to a study published in the December issue of the European Journal of Neurology.
Link:http://www.medicalnewstoday.com/articles/172156.php
Source:Medical News Today

Tetrathiomolybdate for Wilson disease

Fri, 27 Nov 2009 09:42:49 +0000

The copper sequestering drug tetrathiomolybdate (TM) has been shown in studies to be effective in the treatment of Wilson disease, a disease caused by an overload of copper, and certain metastatic cancers.
The study will be published in Science Express Nov. 26.
Link:http://www.eurekalert.org/pub_releases/2009-11/nu-rsl112509.php
Source:EurekAlert