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Keep Alzheimer's Away with A Drink Per Day

2011-09-17T14:51:00.002+08:00

August 26, 2011 — Light to moderate drinking seems to reduce the risk for dementia and cognitive decline, according to a new study published in the August issue of Neuropsychiatric Disease and Treatment.

A meta-analysis of 143 studies on the effects of alcohol on the brain showed that moderate drinking, defined as no more than 2 drinks a day for a man and no more than 1 drink a day for a woman, reduced the risk for Alzheimer's disease and other forms of dementia by 23%.

"It doesn't seem to matter if it's beer, wine, or spirits, as long as the drinking was moderate," Edward J. Neafsey, PhD, from the Department of Molecular Pharmacology and Therapeutics at Loyola University Medical Center, Maywood, Illinois, told Medscape Medical News.

Dr. Neafsey and coauthor Michael A. Collins, PhD, became interested in seeing whether alcohol might be protective of human brains after their experiments showed that rat brains exposed to low doses of alcohol for a few days demonstrated resiliency when subsequently treated with a toxin.

"If the rat brain slices were treated for 5 or 6 days with low alcohol and then the toxin was administered, there was hardly any damage, whereas if they didn't get the pretreatment with alcohol, there was significant damage. This led us to ask if there was anything in the human literature that would fit with this protective effect of alcohol," Dr. Neafsey explained.

The researchers reviewed studies dating from 1977 up to the present. The studies fell into 2 categories: those that provided ratios of risk between drinkers and nondrinkers (n = 74) and those that rated cognition in drinkers as "better," "no different," or "worse" than cognition in nondrinkers (n = 69).

Heavy Drinking a Different Story
Light to moderate drinking conferred a similar benefit, but heavy drinking (more than 3 - 5 drinks/day) was associated with a non-significantly higher risk for dementia and cognitive impairment.

Most of the studies did not distinguish between the different types of alcohol, but in a few studies, wine appeared to be more beneficial than beer or spirits. "It really seemed to be that alcohol per se was protective, not the type, because the few studies that did make the distinction reported no difference among the effects of the different types of alcohol," Dr. Neafsey said.

The protective effect of moderate drinking held after adjusting for age, education, sex, and smoking.

A number of explanations for the protective effect of moderate alcohol have been proposed. Some dementias are related to cardiovascular system problems, such as atherosclerosis, and alcohol may be protective because it raises the level of high-density lipoprotein (the good) cholesterol and might improve blood flow in the brain.

One theory that Dr. Neafsey and Dr. Collins are working on now holds that alcohol acts as a mild stressor for brain cells and "preconditions" them, making them better able to ward off stress.

"Alcohol doesn't kill the brain cells, but it's a slight stress. When the cells are exposed they increase levels of various protective compounds, so...they are prepared when something more stressful that might kill or damage them comes along. The theory is called 'preconditioning,' where a mild stress given a few days before a severe stress causes a significant protection."

Understanding the mechanism of alcohol's protective effect could lead to a treatment to prevent cognitive impairment and dementias, Dr. Neafsey said.

"Whether it's treatment with a pill or a lifestyle change, if we could understand the mechanism, it would improve our ability to deal with these illnesses," he said. [Read More]

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Impotence May Point to Heart Problems

2011-09-15T00:46:00.002+08:00

Impotence could be a harbinger of heart disease in some men, according to a fresh look at the medical literature that found the two often go together.

But it's not all bad news. Another study out today suggests heart-healthy lifestyle changes or cholesterol-lowering drugs could have a positive effect on men's sexual health.

Scientists have known about the link between impotence, or erectile dysfunction, and heart health for years. Although there is no proof so far, a common theory is that arteries supplying the penis with blood during erections may clog up earlier than those in the heart, which are larger -- thus providing an early warning of possible coronary artery disease down the road.

Heart disease is the leading killer worldwide, and erectile dysfunction is estimated to affect some 322 million men by 2025.

To address the connection between the two, Jia-Yi Dong of Soochow University in Suzhou, China, and colleagues combined twelve earlier studies of impotence and heart disease, covering nearly 37,000 men.

"This meta-analysis ... suggests that erectile dysfunction significantly increases the risk of cardiovascular disease, coronary heart disease, stroke and all-cause mortality, and the increase is probably independent of conventional cardiovascular risk factors," they wrote in the Journal of the American College of Cardiology.

They found that men with erectile problems had a 48 percent increase in their risk of developing heart disease, and also had higher death rates than men who didn't have sexual problems.
Traditional risk factors such as smoking, obesity, diabetes and high blood pressure didn't explain the link, strengthening the case that impotence, when it isn't due to partnership problems or other psychological issues, is a risk factor for heart disease in its own right.

But another study, published in the Archives of Internal Medicine, found that both lifestyle changes and cholesterol-lowering drugs such as statins appeared to improve men's erectile problems -- but only a little.

Men who exercises more or were put on a Mediterranean diet rich in whole grain, fruits, vegetables nuts and olive oil, for instance, reported a 2.4 point improvement on a 25-point scale of erectile problems. [Read More]

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2011-09-09T01:37:00.001+08:00

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