DailyUpdates from LeadDiscovery: Breaking Research, Development News and Pharmareports for Drug Discovery http://www.leaddiscovery.co.uk Dedicated to drug discovery, LeadDiscovery was founded in 1998 by life scientists for life scientists. Fri, 10 Oct 2008 20:24:27 GMT DailyUpdates http://www.leaddiscovery.co.uk Breaking Research, Development News and Pharmareports for Drug Discovery http://www.leaddiscovery.co.uk/dailyupdates_RSS_Icon.gif 144 59 http://www.leaddiscovery.co.uk/articles/18809631/dailyupdate?1 http://feeds.feedburner.com/~r/dailyupdates/~3/417095163/dailyupdate Fri, 10 Oct 2008 20:24:26 GMT Efficacy and Safety of the Dipeptidyl Peptidase-4 Inhibitor Alogliptin in Patients With Type 2 Diabetes Mellitus and Inadequate Glycemic Control: A Randomized Double-Blind Placebo-Controlled Study. http://www.leaddiscovery.co.uk/articles/18809631/dailyupdate?1 http://www.leaddiscovery.co.uk/articles/18799330/dailyupdate?2 http://feeds.feedburner.com/~r/dailyupdates/~3/417095165/dailyupdate Fri, 10 Oct 2008 20:24:26 GMT Radiosensitivity of prostate cancer cells is enhanced by EGFR inhibitor C225(). http://www.leaddiscovery.co.uk/articles/18799330/dailyupdate?2 http://www.leaddiscovery.co.uk/articles/18805008/dailyupdate?3 http://feeds.feedburner.com/~r/dailyupdates/~3/417095166/dailyupdate Fri, 10 Oct 2008 20:24:26 GMT Design synthesis and structure-activity relationship of simple bis-amides as potent inhibitors of GlyT1. http://www.leaddiscovery.co.uk/articles/18805008/dailyupdate?3 http://www.leaddiscovery.co.uk/articles/18806806/dailyupdate?4 http://feeds.feedburner.com/~r/dailyupdates/~3/417095169/dailyupdate Fri, 10 Oct 2008 20:24:26 GMT Protective action of doxycycline against diabetic cardiomyopathy in rats. http://www.leaddiscovery.co.uk/articles/18806806/dailyupdate?4 http://www.leaddiscovery.co.uk/articles/18794865/dailyupdate?5 http://feeds.feedburner.com/~r/dailyupdates/~3/417095171/dailyupdate Fri, 10 Oct 2008 20:24:26 GMT A randomized trial of etoposide and G-CSF with or without rituximab for PBSC mobilization in B-cell non-Hodgkins lymphoma. http://www.leaddiscovery.co.uk/articles/18794865/dailyupdate?5 http://www.leaddiscovery.co.uk/articles/18802403/dailyupdate?6 http://feeds.feedburner.com/~r/dailyupdates/~3/417095173/dailyupdate Fri, 10 Oct 2008 20:24:26 GMT Mdm2 exerts pro-apoptotic activities by antagonizing insulin-like growth factor-I-mediated survival. http://www.leaddiscovery.co.uk/articles/18802403/dailyupdate?6 http://www.leaddiscovery.co.uk/articles/18807123/dailyupdate?7 http://feeds.feedburner.com/~r/dailyupdates/~3/417095174/dailyupdate Fri, 10 Oct 2008 20:24:26 GMT Efficacy of S-1 in heavily pretreated patients with metastatic breast cancer: cross-resistance to capecitabine. http://www.leaddiscovery.co.uk/articles/18807123/dailyupdate?7 http://www.leaddiscovery.co.uk/articles/18783207/dailyupdate?8 http://feeds.feedburner.com/~r/dailyupdates/~3/417095175/dailyupdate Fri, 10 Oct 2008 20:24:26 GMT Novel A - Ring and B - Ring Modified Combretastatin A - 4 (CA - 4) Analogues Endowed with Interesting Cytotoxic Activity. http://www.leaddiscovery.co.uk/articles/18783207/dailyupdate?8 http://www.leaddiscovery.co.uk/articles/18801952/dailyupdate?9 http://feeds.feedburner.com/~r/dailyupdates/~3/417095176/dailyupdate Fri, 10 Oct 2008 20:24:26 GMT Prognostic Significance of (18) F-Fluorodeoxyglucose - Positron Emission Tomography after Treatment in Patients with Limited Stage Small Cell Lung Cancer. http://www.leaddiscovery.co.uk/articles/18801952/dailyupdate?9 http://www.leaddiscovery.co.uk/articles/18718906/dailyupdate?10 http://feeds.feedburner.com/~r/dailyupdates/~3/417095177/dailyupdate Fri, 10 Oct 2008 20:24:26 GMT Targeted induction of lung endothelial cell apoptosis causes emphysema - like changes in the mouse. http://www.leaddiscovery.co.uk/articles/18718906/dailyupdate?10 http://www.leaddiscovery.co.uk/articles/18789558/dailyupdate?11 http://feeds.feedburner.com/~r/dailyupdates/~3/417095179/dailyupdate Fri, 10 Oct 2008 20:24:26 GMT 24 - Substituted - 9 - fluorenones and their O - glucosides as potential immunomodulators and anti - herpes simplex virus - 2 agents. Part 5. http://www.leaddiscovery.co.uk/articles/18789558/dailyupdate?11 http://www.leaddiscovery.co.uk/articles/18800766/dailyupdate?12 http://feeds.feedburner.com/~r/dailyupdates/~3/417095181/dailyupdate Fri, 10 Oct 2008 20:24:26 GMT Phosphoramidate dinucleosides as hepatitis C virus polymerase inhibitors. http://www.leaddiscovery.co.uk/articles/18800766/dailyupdate?12 http://www.leaddiscovery.co.uk/articles/18801389/dailyupdate?13 http://feeds.feedburner.com/~r/dailyupdates/~3/417095182/dailyupdate Fri, 10 Oct 2008 20:24:26 GMT Stimulation of 5-HT1A or 5-HT2A receptors in the ventrolateral periaqueductal gray causes anxiolytic- but not panicolytic-like effect in rats. http://www.leaddiscovery.co.uk/articles/18801389/dailyupdate?13 http://www.leaddiscovery.co.uk/articles/18789921/dailyupdate?14 http://feeds.feedburner.com/~r/dailyupdates/~3/417095186/dailyupdate Fri, 10 Oct 2008 20:24:26 GMT Antidepressant-like effect of folic acid: Involvement of NMDA receptors and l-arginine nitric oxide-cyclic guanosine monophosphate pathway. http://www.leaddiscovery.co.uk/articles/18789921/dailyupdate?14 http://www.leaddiscovery.co.uk/articles/18799798/dailyupdate?15 http://feeds.feedburner.com/~r/dailyupdates/~3/417095204/dailyupdate Fri, 10 Oct 2008 20:24:26 GMT Over-expression of Heme oxygenase-1 protects dopaminergic neurons against 1-methyl-4-phenylpyridinium-induced neurotoxicity. http://www.leaddiscovery.co.uk/articles/18799798/dailyupdate?15 http://www.leaddiscovery.co.uk/articles/18682582/dailyupdate?16 http://feeds.feedburner.com/~r/dailyupdates/~3/417095206/dailyupdate Fri, 10 Oct 2008 20:24:26 GMT MR Assessment of Myocardial Perfusion Viability and Function after Intramyocardial Transfer of VM202 a New Plasmid Human Hepatocyte Growth Factor in Ischemic Swine Myocardium. http://www.leaddiscovery.co.uk/articles/18682582/dailyupdate?16 http://www.leaddiscovery.co.uk/news/3520?17 http://feeds.feedburner.com/~r/dailyupdates/~3/417095209/3520 Fri, 10 Oct 2008 20:24:26 GMT FDA approves AstraZenecas SEROQUEL XR for the treatment of bipolar depression and bipolar mania http://www.leaddiscovery.co.uk/news/3520?17 http://www.leaddiscovery.co.uk/news/3517?18 http://feeds.feedburner.com/~r/dailyupdates/~3/417095210/3517 Fri, 10 Oct 2008 20:24:26 GMT Icagen Initiates Phase II Proof-of-Concept Trial in Allergic Asthma for Senicapoc Potassium Channel Blocker http://www.leaddiscovery.co.uk/news/3517?18 http://www.leaddiscovery.co.uk/news/3518?19 http://feeds.feedburner.com/~r/dailyupdates/~3/417095213/3518 Fri, 10 Oct 2008 20:24:26 GMT FDA to continue review of Alogliptin NDA http://www.leaddiscovery.co.uk/news/3518?19 http://www.leaddiscovery.co.uk/news/3519?20 http://feeds.feedburner.com/~r/dailyupdates/~3/417095214/3519 Fri, 10 Oct 2008 20:24:26 GMT Phase II-b trials for Oglemilast(GRC 3886) in Asthma initiated http://www.leaddiscovery.co.uk/news/3519?20 http://www.leaddiscovery.co.uk/news/3521?21 http://feeds.feedburner.com/~r/dailyupdates/~3/417095218/3521 Fri, 10 Oct 2008 20:24:26 GMT Cardiome Provides Regulatory Update http://www.leaddiscovery.co.uk/news/3521?21 http://www.leaddiscovery.co.uk/news/3522?22 http://feeds.feedburner.com/~r/dailyupdates/~3/417095222/3522 Fri, 10 Oct 2008 20:24:26 GMT Biogen Idec Announces Top-Line Results from Phase II Clinical Trial of Baminercept in Rheumatoid Arthritis http://www.leaddiscovery.co.uk/news/3522?22 http://www.leaddiscovery.co.uk/trials/3441?23 http://feeds.feedburner.com/~r/dailyupdates/~3/417095226/3441 Fri, 10 Oct 2008 20:24:26 GMT Phase II Study of AZD2281 in Known BRCA or Recurrent High Grade Ovarian Cancer or Known BRCA Triple Neg Breast Cancer http://www.leaddiscovery.co.uk/trials/3441?23 http://www.leaddiscovery.co.uk/trials/3442?24 http://feeds.feedburner.com/~r/dailyupdates/~3/417095228/3442 Fri, 10 Oct 2008 20:24:26 GMT Capecitabine and Lapatinib With or Without Monoclonal Antibody Therapy in Treating Patients With Previously Treated HER2-Positive Stage IIIB Stage IIIC or Stage IV Breast Cancer http://www.leaddiscovery.co.uk/trials/3442?24 http://www.leaddiscovery.co.uk/reports/172?25 http://feeds.feedburner.com/~r/dailyupdates/~3/417095232/172 Fri, 10 Oct 2008 20:24:27 GMT Personalized Medicine - scientific and commercial aspects http://www.leaddiscovery.co.uk/reports/172?25 http://www.leaddiscovery.co.uk/reports/178?26 http://feeds.feedburner.com/~r/dailyupdates/~3/417095235/178 Fri, 10 Oct 2008 20:24:27 GMT Nanobiotechnologies- applications markets and companies http://www.leaddiscovery.co.uk/reports/178?26 http://www.leaddiscovery.co.uk/reports/179?27 http://feeds.feedburner.com/~r/dailyupdates/~3/417095237/179 Fri, 10 Oct 2008 20:24:27 GMT Drug Delivery in Central Nervous System Diseases - technologiesmarkets and companies http://www.leaddiscovery.co.uk/reports/179?27 http://www.leaddiscovery.co.uk/reports/180?28 http://feeds.feedburner.com/~r/dailyupdates/~3/417095239/180 Fri, 10 Oct 2008 20:24:27 GMT Cardiovascular Drug Delivery - technologiesmarkets and companies http://www.leaddiscovery.co.uk/reports/180?28 http://www.leaddiscovery.co.uk/reports/181?29 http://feeds.feedburner.com/~r/dailyupdates/~3/417095241/181 Fri, 10 Oct 2008 20:24:27 GMT Biomarkers - technologiesmarkets and companies http://www.leaddiscovery.co.uk/reports/181?29 http://www.leaddiscovery.co.uk/reports/182?30 http://feeds.feedburner.com/~r/dailyupdates/~3/417095244/182 Fri, 10 Oct 2008 20:24:27 GMT Cytogenetics - technologiesmarkets and companies http://www.leaddiscovery.co.uk/reports/182?30 http://www.leaddiscovery.co.uk/reports/414?31 http://feeds.feedburner.com/~r/dailyupdates/~3/417095246/414 Fri, 10 Oct 2008 20:24:27 GMT Antiviral Therapeutics - technologies markets and companies http://www.leaddiscovery.co.uk/reports/414?31