DailyUpdates from LeadDiscovery: Breaking Research, Development News and Pharmareports for Drug Discovery http://www.leaddiscovery.co.uk Dedicated to drug discovery, LeadDiscovery was founded in 1998 by life scientists for life scientists. Thu, 09 Jul 2009 18:41:14 GMT DailyUpdates http://www.leaddiscovery.co.uk Breaking Research, Development News and Pharmareports for Drug Discovery http://www.leaddiscovery.co.uk/dailyupdates_RSS_Icon.gif 144 59 http://www.leaddiscovery.co.uk/articles/19515559/dailyupdate?1 http://feedproxy.google.com/~r/dailyupdates/~3/y39l95Jk_6k/dailyupdate Thu, 09 Jul 2009 18:41:12 GMT Design synthesis and biological evaluation of 2H - benzob14 oxazine derivatives as hypoxia targeted compounds for cancer therapeutics. http://www.leaddiscovery.co.uk/articles/19515559/dailyupdate?1 http://www.leaddiscovery.co.uk/articles/19515536/dailyupdate?2 http://feedproxy.google.com/~r/dailyupdates/~3/Ls_KB-IHhP0/dailyupdate Thu, 09 Jul 2009 18:41:12 GMT Extended release metformin for metabolic control assistance during prolonged clozapine administration: A 14 week double-blind parallel group placebo-controlled study. http://www.leaddiscovery.co.uk/articles/19515536/dailyupdate?2 http://www.leaddiscovery.co.uk/articles/19512981/dailyupdate?3 http://feedproxy.google.com/~r/dailyupdates/~3/5f-Env_24VA/dailyupdate Thu, 09 Jul 2009 18:41:12 GMT Effects of escitalopram on anxiety and respiratory responses to carbon dioxide inhalation in subjects at high risk for panic disorder: a placebo-controlled crossover study. http://www.leaddiscovery.co.uk/articles/19512981/dailyupdate?3 http://www.leaddiscovery.co.uk/articles/19515569/dailyupdate?4 http://feedproxy.google.com/~r/dailyupdates/~3/gbk6QMVLCqI/dailyupdate Thu, 09 Jul 2009 18:41:12 GMT Novel 3alpha - methoxyserrat - 14 - en - 21beta - ol (PJ - 1) and 3beta - methoxyserrat - 14 - en - 21beta - ol (PJ - 2) - curcumin kojic acid quercetin and baicalein conjugates as HIV agents. http://www.leaddiscovery.co.uk/articles/19515569/dailyupdate?4 http://www.leaddiscovery.co.uk/articles/19515564/dailyupdate?5 http://feedproxy.google.com/~r/dailyupdates/~3/Qi59C1UL-W8/dailyupdate Thu, 09 Jul 2009 18:41:12 GMT Substituted benzothiadizine inhibitors of Hepatitis C virus polymerase. http://www.leaddiscovery.co.uk/articles/19515564/dailyupdate?5 http://www.leaddiscovery.co.uk/articles/19422381/dailyupdate?6 http://feedproxy.google.com/~r/dailyupdates/~3/CmzJpIUKsFY/dailyupdate Thu, 09 Jul 2009 18:41:12 GMT Characterization of ZK 245186 a novel selective glucocorticoid receptor agonist for the topical treatment of inflammatory skin diseases. http://www.leaddiscovery.co.uk/articles/19422381/dailyupdate?6 http://www.leaddiscovery.co.uk/articles/19517214/dailyupdate?7 http://feedproxy.google.com/~r/dailyupdates/~3/XhrgFP47ADo/dailyupdate Thu, 09 Jul 2009 18:41:12 GMT Effects of the ACE2 inhibitor GL1001 on acute dextran sodium sulfate-induced colitis in mice. http://www.leaddiscovery.co.uk/articles/19517214/dailyupdate?7 http://www.leaddiscovery.co.uk/articles/19515724/dailyupdate?8 http://feedproxy.google.com/~r/dailyupdates/~3/Nrdc3EYbzfw/dailyupdate Thu, 09 Jul 2009 18:41:12 GMT Pretargeting CD45 enhances the selective delivery of radiation to hematolymphoid tissues in nonhuman primates. http://www.leaddiscovery.co.uk/articles/19515724/dailyupdate?8 http://www.leaddiscovery.co.uk/articles/19509000/dailyupdate?9 http://feedproxy.google.com/~r/dailyupdates/~3/dborBG9o6dc/dailyupdate Thu, 09 Jul 2009 18:41:13 GMT A Phase II Study of Paclitaxel and Nedaplatin as First-line Chemotherapy in Patients with Advanced Esophageal Cancer. http://www.leaddiscovery.co.uk/articles/19509000/dailyupdate?9 http://www.leaddiscovery.co.uk/articles/19509253/dailyupdate?10 http://feedproxy.google.com/~r/dailyupdates/~3/I02w2C-8jQw/dailyupdate Thu, 09 Jul 2009 18:41:13 GMT Vorinostat enhances the radiosensitivity of a breast cancer brain metastatic cell line grown in vitro and as intracranial xenografts. http://www.leaddiscovery.co.uk/articles/19509253/dailyupdate?10 http://www.leaddiscovery.co.uk/articles/19515553/dailyupdate?11 http://feedproxy.google.com/~r/dailyupdates/~3/L0OyCb-uJ_8/dailyupdate Thu, 09 Jul 2009 18:41:13 GMT Phase 3 randomised study of canfosfamide (Telcyta((R)) TLK286) versus pegylated liposomal doxorubicin or topotecan as third-line therapy in patients with platinum-refractory or -resistant ovarian cancer. http://www.leaddiscovery.co.uk/articles/19515553/dailyupdate?11 http://www.leaddiscovery.co.uk/articles/19509254/dailyupdate?12 http://feedproxy.google.com/~r/dailyupdates/~3/S70CwW2hIlg/dailyupdate Thu, 09 Jul 2009 18:41:13 GMT Novel benzylidene-thiazolidine-24-diones inhibit Pim protein kinase activity and induce cell cycle arrest in leukemia and prostate cancer cells. http://www.leaddiscovery.co.uk/articles/19509254/dailyupdate?12 http://www.leaddiscovery.co.uk/articles/19509138/dailyupdate?13 http://feedproxy.google.com/~r/dailyupdates/~3/LZG-5O2gTWY/dailyupdate Thu, 09 Jul 2009 18:41:13 GMT Antitumor Activity of NK012 Combined with Cisplatin against Small Cell Lung Cancer and Intestinal Mucosal Changes in Tumor-Bearing Mouse after Treatment. http://www.leaddiscovery.co.uk/articles/19509138/dailyupdate?13 http://www.leaddiscovery.co.uk/articles/19509562/dailyupdate?14 http://feedproxy.google.com/~r/dailyupdates/~3/Ucqgng10398/dailyupdate Thu, 09 Jul 2009 18:41:13 GMT Prevalence and determinants of metabolic syndrome and elevated Framingham risk score in epithelial ovarian cancer survivors: a controlled observational study. http://www.leaddiscovery.co.uk/articles/19509562/dailyupdate?14 http://www.leaddiscovery.co.uk/articles/19515068/dailyupdate?15 http://feedproxy.google.com/~r/dailyupdates/~3/e6rjtgh1bgc/dailyupdate Thu, 09 Jul 2009 18:41:13 GMT Analgesic properties of S100A9 C-terminal domain: a mechanism dependent on calcium channel inhibition. http://www.leaddiscovery.co.uk/articles/19515068/dailyupdate?15 http://www.leaddiscovery.co.uk/articles/19513085/dailyupdate?16 http://feedproxy.google.com/~r/dailyupdates/~3/CSwUHrmBDqg/dailyupdate Thu, 09 Jul 2009 18:41:13 GMT Postischemic IGF-1 gene transfer promotes neurovascular regeneration after experimental stroke. http://www.leaddiscovery.co.uk/articles/19513085/dailyupdate?16 http://www.leaddiscovery.co.uk/articles/19515253/dailyupdate?17 http://feedproxy.google.com/~r/dailyupdates/~3/_DJq_Rhrnmo/dailyupdate Thu, 09 Jul 2009 18:41:13 GMT Dopamine Agonists and their risk to induce psychotic episodes in Parkinsons disease: a case-control study. http://www.leaddiscovery.co.uk/articles/19515253/dailyupdate?17 http://www.leaddiscovery.co.uk/articles/19515415/dailyupdate?18 http://feedproxy.google.com/~r/dailyupdates/~3/ZiagKy3Pibg/dailyupdate Thu, 09 Jul 2009 18:41:13 GMT Effect of the dual peroxisome proliferator-activated receptor-alphagamma agonist aleglitazar on risk of cardiovascular disease in patients with type 2 diabetes (SYNCHRONY): a phase II randomised dose-ranging study. http://www.leaddiscovery.co.uk/articles/19515415/dailyupdate?18 http://www.leaddiscovery.co.uk/articles/19515179/dailyupdate?19 http://feedproxy.google.com/~r/dailyupdates/~3/x_24ttT-wqo/dailyupdate Thu, 09 Jul 2009 18:41:13 GMT Comparison of vildagliptin and pioglitazone in patients with type 2 diabetes inadequately controlled with metformin. http://www.leaddiscovery.co.uk/articles/19515179/dailyupdate?19 http://www.leaddiscovery.co.uk/articles/19515180/dailyupdate?20 http://feedproxy.google.com/~r/dailyupdates/~3/MKSgItAt0f0/dailyupdate Thu, 09 Jul 2009 18:41:13 GMT Metabolic effects of sustained activation of the GLP-1 receptor alone and in combination with background GIP receptor antagonism in high fat-fed mice. http://www.leaddiscovery.co.uk/articles/19515180/dailyupdate?20 http://www.leaddiscovery.co.uk/articles/19514849/dailyupdate?21 http://feedproxy.google.com/~r/dailyupdates/~3/tNSJt67U-r8/dailyupdate Thu, 09 Jul 2009 18:41:13 GMT The novel nitric oxide synthase inhibitor 4-amino-tetrahydro-L-biopterine prevents brain edema formation and intracranial hypertension following traumatic brain injury in mice. http://www.leaddiscovery.co.uk/articles/19514849/dailyupdate?21 http://www.leaddiscovery.co.uk/articles/19515967/dailyupdate?22 http://feedproxy.google.com/~r/dailyupdates/~3/rAE8lWsmAO0/dailyupdate Thu, 09 Jul 2009 18:41:13 GMT Effects of beta 3 adrenergic receptor activation on rat urinary bladder hyperactivity induced by ovariectomy. http://www.leaddiscovery.co.uk/articles/19515967/dailyupdate?22 http://www.leaddiscovery.co.uk/articles/19516889/dailyupdate?23 http://feedproxy.google.com/~r/dailyupdates/~3/GvAEPGfu3dM/dailyupdate Thu, 09 Jul 2009 18:41:13 GMT The reversal effect of magnetic Fe3O4 nanoparticles loaded with cisplatin on SKOV3DDP ovarian carcinoma cells. http://www.leaddiscovery.co.uk/articles/19516889/dailyupdate?23 http://www.leaddiscovery.co.uk/news/5159?24 http://feedproxy.google.com/~r/dailyupdates/~3/0MlZ58ZbKXg/5159 Thu, 09 Jul 2009 18:41:14 GMT Rigels R788 Significantly Improves Rheumatoid Arthritis in Phase 2b Clinical Trial http://www.leaddiscovery.co.uk/news/5159?24 http://www.leaddiscovery.co.uk/news/5157?25 http://feedproxy.google.com/~r/dailyupdates/~3/oYj92T9Nk0Q/5157 Thu, 09 Jul 2009 18:41:14 GMT Spectrum Pharmaceuticals Submitted Formal Response to FDA Complete Response Letter on Wednesday July 8 2009 http://www.leaddiscovery.co.uk/news/5157?25 http://www.leaddiscovery.co.uk/news/5158?26 http://feedproxy.google.com/~r/dailyupdates/~3/KbFu-T-26Mw/5158 Thu, 09 Jul 2009 18:41:14 GMT Peplin Completes Enrolment in its Phase 3 Clinical Trials for PEP005 Gel in AK on the Face and Scalp http://www.leaddiscovery.co.uk/news/5158?26 http://www.leaddiscovery.co.uk/news/5160?27 http://feedproxy.google.com/~r/dailyupdates/~3/TZSclKFxYUw/5160 Thu, 09 Jul 2009 18:41:14 GMT Array BioPharma Announces Top-Line Results in Two Phase 1 Clinical Trials http://www.leaddiscovery.co.uk/news/5160?27 http://www.leaddiscovery.co.uk/trials/5502?28 http://feedproxy.google.com/~r/dailyupdates/~3/ZK1ihVDJVnE/5502 Thu, 09 Jul 2009 18:41:14 GMT A Phase 2 Trial of MLN8237 in Adult Patients With Acute Myelogenous Leukemia and High-Grade Myelodysplastic Syndrome http://www.leaddiscovery.co.uk/trials/5502?28 http://www.leaddiscovery.co.uk/trials/5503?29 http://feedproxy.google.com/~r/dailyupdates/~3/cVCmzOiycjw/5503 Thu, 09 Jul 2009 18:41:14 GMT E7080 in Combination With Carboplatin and Paclitaxel in Patients With Non-Small Cell Lung Cancer (NSCLC) http://www.leaddiscovery.co.uk/trials/5503?29 http://www.leaddiscovery.co.uk/trials/6497?30 http://feedproxy.google.com/~r/dailyupdates/~3/fFnxHihJ9zM/6497 Thu, 09 Jul 2009 18:41:14 GMT XAD - Xelox (Capecitabine Oxaliplatin) Bevacizumab Dasatinib http://www.leaddiscovery.co.uk/trials/6497?30 http://www.leaddiscovery.co.uk/reports/1469?31 http://feedproxy.google.com/~r/dailyupdates/~3/slzCpA2Ezq0/1469 Thu, 09 Jul 2009 18:41:14 GMT Forecast Insight: Inflammatory Bowel Disease - New product launches sustain long-term market growth http://www.leaddiscovery.co.uk/reports/1469?31